# For Debian currently with # # cd build # cmake -DCMAKE_BUILD_TYPE=RelWithDebInfo -DZIG=OFF .. # cmake --build . # ctest . # cmake --install . # cmake_minimum_required(VERSION 3.16) project(vcflib) set(CMAKE_CXX_STANDARD 17) include(ExternalProject) include(FeatureSummary) include(GNUInstallDirs) find_package(PkgConfig REQUIRED) find_package(pybind11 CONFIG) include(GNUInstallDirs) include(FindBZip2) include(FindLibLZMA) include(FindZLIB) include(FindCURL) # for htslib feature_summary( FATAL_ON_MISSING_REQUIRED_PACKAGES WHAT REQUIRED_PACKAGES_NOT_FOUND) set(CMAKE_POSITION_INDEPENDENT_CODE ON) # for pybind11 # ---- Options option(BUILD_DOC "Build documentation" ON) option(OPENMP "Enable OpenMP" ON) # disabling does not work because of vcfwave option(PROFILING "Enable profiling" OFF) option(GPROF "Enable gprof profiling" OFF) option(ASAN "Use address sanitiser" OFF) option(ZIG "Set to OFF to disable the zig code" ON) option(WFA_GITMODULE "Force local git submodule for WFA2LIB" OFF) # disabled by default now include(CheckIPOSupported) # adds lto check_ipo_supported(RESULT ipo_supported OUTPUT output) set(EXTRA_FLAGS " ") # otherwise it injects OFF # ---- Dependencies if(OPENMP) include(FindOpenMP) SET(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${OpenMP_C_FLAGS}") SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${OpenMP_CXX_FLAGS}") endif(OPENMP) find_package(ZLIB) set_package_properties(ZLIB PROPERTIES TYPE REQUIRED) find_package(Threads) set_package_properties(Threads PROPERTIES TYPE REQUIRED) pkg_check_modules(HTSLIB htslib) # Optionally builds from contrib/ pkg_check_modules(TABIXPP tabixpp) # Optionally builds from contrib/ pkg_check_modules(SMITHWATERMAN REQUIRED IMPORTED_TARGET libsmithwaterman) pkg_check_modules(FASTAHACK REQUIRED IMPORTED_TARGET libfastahack) # ---- Build switches set(CMAKE_POSITION_INDEPENDENT_CODE ON) set(CMAKE_INTERPROCEDURAL_OPTIMIZATION ${ipo_supported}) if(NOT CMAKE_BUILD_TYPE) set(CMAKE_BUILD_TYPE Release CACHE STRING "Choose the type of build, options are: Release|Debug|RelWithDebInfo (for distros)." FORCE) endif() if (${CMAKE_BUILD_TYPE} MATCHES Release) set(EXTRA_FLAGS "-march=native -D_FILE_OFFSET_BITS=64") # set(CMAKE_CXX_FLAGS_RELEASE "-DNDEBUG") # reset CXX_FLAGS to replace -O3 with -Ofast endif() if ((${CMAKE_BUILD_TYPE} MATCHES Release) OR (${CMAKE_BUILD_TYPE} MATCHES RelWithDebInfo)) set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${EXTRA_FLAGS}") set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${EXTRA_FLAGS}") endif () if (${CMAKE_BUILD_TYPE} MATCHES "Debug") set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${EXTRA_FLAGS}") set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${EXTRA_FLAGS}") add_definitions(-Wfatal-errors) # stop after first error endif () if (ASAN) set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fsanitize=address -fno-omit-frame-pointer -fno-common") set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -fsanitize=address -fno-omit-frame-pointer -fno-common") endif(ASAN) if(PROFILING) set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -g") endif(PROFILING) if(GPROF) set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -pg") endif(GPROF) if (ZIG) find_program(ZIG_EXE NAMES "zig") if (NOT ZIG_EXE) MESSAGE(FATAL_ERROR "zig binary not found in PATH. zig is used for vcfcreatemulti's latest features. Either use cmake -DZIG=OFF option or add zig to the PATH") endif (NOT ZIG_EXE) endif(ZIG) # ---- Include files include_directories(include) include_directories(contrib/intervaltree) # include_directories(contrib/multichoose) merged with vcflib include_directories(contrib/filevercmp) include_directories(contrib/c-progress-bar) if(HTSLIB_FOUND) list(JOIN HTSLIB_CFLAGS " " HTSLIB_CFLAGS_STRING) set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${HTSLIB_CFLAGS_STRING}") set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${HTSLIB_CFLAGS_STRING}") else(HTSLIB_FOUND) message(STATUS "Using included htslib") set(HTSLIB_LOCAL contrib/tabixpp/htslib) set(TABIXPP_FOUND OFF) # also build tabixpp if htslib is missing endif() if(TABIXPP_FOUND) list(JOIN TABIXPP_CFLAGS " " TABIXPP_CFLAGS_STRING) set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${TABIXPP_CFLAGS_STRING}") set (CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} ${TABIXPP_CFLAGS_STRING}") else(TABIXPP_FOUND) message(STATUS "Using included tabixpp") set(TABIXPP_LOCAL contrib/tabixpp) include_directories(contrib/tabixpp) set(tabixpp_SOURCE /usr/include/tabix.hpp ) endif() if(WFA_GITMODULE) set(WFA_LOCAL contrib/WFA2-lib) endif() file(GLOB INCLUDES src/*.h* # contrib/multichoose/*.h* contrib/intervaltree/*.h* contrib/filevercmp/*.h* ) set(vcfwfa_SOURCE src/legacy.cpp # introduces a WFA dependency src/vcf-wfa.cpp ) set(vcflib_SOURCE ${vcfwfa_SOURCE} src/vcf-c-api.cpp src/Variant.cpp src/canonicalize.cpp src/rnglib.cpp src/var.cpp src/pdflib.cpp src/cdflib.cpp src/split.cpp src/rkmh.cpp src/murmur3.cpp src/LeftAlign.cpp src/cigar.cpp src/allele.cpp contrib/filevercmp/filevercmp.c contrib/c-progress-bar/progress.c ) if (TABIXPP_LOCAL) # add the tabixpp source file list(APPEND vcflib_SOURCE ${tabixpp_SOURCE}) endif() add_library(vcflib SHARED ${vcflib_SOURCE} ) target_link_libraries(vcflib PkgConfig::SMITHWATERMAN PkgConfig::FASTAHACK tabixpp wfa2 ) set(BINS vcfecho dumpContigsFromHeader bFst pVst hapLrt popStats wcFst iHS segmentFst segmentIhs genotypeSummary sequenceDiversity pFst smoother vcfld plotHaps abba-baba permuteGPAT++ permuteSmooth normalize-iHS meltEHH vcfnullgenofields vcfaltcount vcfhetcount vcfhethomratio vcffilter vcf2tsv vcfgenotypes vcfannotategenotypes vcfcommonsamples vcfremovesamples vcfkeepsamples vcfsamplenames vcfgenotypecompare vcffixup vcfclassify vcfsamplediff vcfremoveaberrantgenotypes vcfrandom vcfflatten vcfprimers vcfnumalt vcfintersect vcfannotate vcfoverlay vcfaddinfo vcfkeepinfo vcfkeepgeno vcfafpath vcfcountalleles vcflength vcfdistance vcfrandomsample vcfentropy vcfglxgt vcfcheck vcfstreamsort vcfuniq vcfuniqalleles vcfremap vcf2fasta vcfsitesummarize vcfbreakmulti vcfevenregions vcfcat vcfgenosummarize vcfgenosamplenames vcfgeno2haplo vcfleftalign vcfcombine vcfgeno2alleles vcfindex vcf2dag vcfsample2info vcfqual2info vcfinfo2qual vcfglbound vcfinfosummarize vcfcreatemulti ) set(WFBINS # Introduce wavefront dependency vcfallelicprimitives vcfcleancomplex vcfparsealts vcfroc vcfstats vcfwave ) set(SCRIPTS bed2region bgziptabix vcf2bed.py vcf2sqlite.py vcfbiallelic vcfclearid vcfclearinfo vcfcomplex vcffirstheader vcfgtcompare.sh vcfindelproximity vcfindels vcfjoincalls vcfmultiallelic vcfmultiway vcfmultiwayscripts vcfnobiallelicsnps vcfnoindels vcfnosnps vcfnulldotslashdot vcfplotaltdiscrepancy.r vcfplotaltdiscrepancy.sh vcfplotsitediscrepancy.r vcfplottstv.sh vcfprintaltdiscrepancy.r vcfprintaltdiscrepancy.sh vcfqualfilter vcfregionreduce vcfregionreduce_and_cut vcfregionreduce_pipe vcfregionreduce_uncompressed vcfremovenonATGC vcfsnps vcfsort vcf_strip_extra_headers vcfvarstats ) # ---- Get version file (STRINGS "VERSION" BUILD_NUMBER) add_definitions(-DVCFLIB_VERSION="${BUILD_NUMBER}") add_definitions(-DVERSION="${BUILD_NUMBER}") string(REGEX MATCH "^[0-9]+" MAJOR_BUILD_NUMBER ${BUILD_NUMBER}) set_target_properties(vcflib PROPERTIES SOVERSION 2 ) # ---- Build htslib # # Note by default we use the distributed htslib! These are # the older instructions which allow for a local build from # git submodules if (HTSLIB_LOCAL) include_directories(${HTSLIB_LOCAL}) set(flags "-O2 -g -fPIC") ExternalProject_Add(htslib-EXT SOURCE_DIR "${CMAKE_SOURCE_DIR}/${HTSLIB_LOCAL}" UPDATE_COMMAND autoreconf -i CONFIGURE_COMMAND ./configure --disable-s3 INSTALL_COMMAND "" BUILD_IN_SOURCE ON BUILD_COMMAND $(MAKE) CFLAGS=${flags} lib-static ) ExternalProject_Get_property(htslib-EXT SOURCE_DIR) ExternalProject_Get_property(htslib-EXT INSTALL_DIR) set(htslib_INCLUDE "${SOURCE_DIR}") set(htslib_static "${SOURCE_DIR}/libhts.a") set(htslib_lib "${htslib_static}") set(HTSLIB_LINK_LIBRARIES "${htslib_static}") add_custom_target(htslib DEPENDS htslib-EXT VERBATIM) # set_property(TARGET htslib PROPERTY IMPORTED_LOCATION ${hstlib_lib}) # add_dependencies(htslib htslib-EXT) add_library(HTSLIB_LIBRARIES STATIC IMPORTED) set_target_properties(HTSLIB_LIBRARIES PROPERTIES IMPORTED_LOCATION ${htslib_lib}) add_dependencies(HTSLIB_LIBRARIES htslib-EXT) # If the user wants to configure our HTSlib to build with libddeflate, we need # to make sure to link against libdeflate as a transitive dependency. To do # that, pass -DHTSLIB_EXTRA_LIBS="-ldeflate" when configuring the project with # cmake. # TODO: Stop vendoring in htslib and just use find_package # set(HTSLIB_EXTRA_LIBS "-lcurl" CACHE STRING "Library flags needed to link with htslib's dependencies, for chosen configuration") # set_property(TARGET htslib PROPERTY INTERFACE_LINK_LIBRARIES ${HTSLIB_EXTRA_LIBS}) endif(HTSLIB_LOCAL) if(WFA_GITMODULE) message(STATUS "Using included libwfa") set(WFA_INCLUDE_DIRS ${WFA_LOCAL}) add_subdirectory(${WFA_LOCAL}) set(WFALIB wfa2) # pick up the wfa2 lib target from the included CMakeLists.txt else(WFA_GITMODULE) include_directories($ENV{CMAKE_PREFIX_PATH}/include/wfa2lib) set(WFA_INCLUDE_DIRS ${CMAKE_INSTALL_PREFIX}/${CMAKE_INSTALL_INCLUDEDIR}/wfa2lib) find_library(WFALIB wfa2 wfa REQUIRED) # distro search for shared lib endif(WFA_GITMODULE) # if(NOT WFALIB) # message(STATUS "ERROR: Can not find wfa2lib! Make sure it is installed or use the git submodule instead") # endif() include_directories(${WFA_INCLUDE_DIRS}) MESSAGE(STATUS "WFA using include ${WFA_INCLUDE_DIRS}") # ZIG VCF imported library is part of VCFLIB source tree. We designate it an # external project so we can run 'zig build' if (ZIG) ExternalProject_Add(ZIG-EXT SOURCE_DIR "${CMAKE_SOURCE_DIR}/src/zig" UPDATE_COMMAND "" CONFIGURE_COMMAND "" INSTALL_COMMAND "" BUILD_IN_SOURCE ON BUILD_ALWAYS ON BUILD_COMMAND ${CMAKE_SOURCE_DIR}/src/zig/compile.sh # -Drelease-fast=true -freference-trace ) ExternalProject_Get_property(ZIG-EXT SOURCE_DIR) set(ZIG_INCLUDE_DIRS ${SOURCE_DIR}) set(ZIG_LINK_LIBRARIES ${SOURCE_DIR}/zig-out/lib/libzig.a) add_library(ZIGCPP_STATIC_LIB STATIC IMPORTED) set_target_properties(ZIGCPP_STATIC_LIB PROPERTIES IMPORTED_LOCATION ${ZIG_LINK_LIBRARIES}) add_dependencies(ZIGCPP_STATIC_LIB ZIG-EXT vcf.zig) include_directories(${ZIG_INCLUDE_DIRS}) else (ZIG) set (ZIG_LINK_LIBRARIES ) add_definitions(-DNO_ZIG=1) endif (ZIG) set(vcflib_DEPS CURL::libcurl ) if (ZIG) list(APPEND vcflib_DEPS ZIG-EXT) endif () if (HTSLIB_LOCAL) list(APPEND vcflib_DEPS htslib) endif() set(vcflib_LIBS ${HTSLIB_LIBRARIES} ${CURL_LIBRARIES} ${ZLIB_LIBRARIES} ${LIBLZMA_LIBRARIES} ${BZIP2_LIBRARIES} ${TABIXPP_LIBRARIES} ${CMAKE_THREAD_LIBS_INIT} ${WFA_LINK_LIBRARIES} ${HTSLIB_LINK_LIBRARIES} ) if (ZIG) list(APPEND vcflib_LIBS ${ZIG_LINK_LIBRARIES}) endif() add_dependencies(vcflib ${vcflib_DEPS}) # ---- Build all if (NOT BUILD_ONLY_LIB) foreach(BIN ${BINS}) add_executable(${BIN} src/${BIN}.cpp) add_dependencies(${BIN} vcflib) target_link_libraries(${BIN} PUBLIC ${vcflib_LIBS} vcflib) endforeach(BIN ${BINS}) foreach(WFBIN ${WFBINS}) add_executable(${WFBIN} src/${WFBIN}.cpp ${vcfwfa_SOURCE}) add_dependencies(${WFBIN} vcflib) target_link_libraries(${WFBIN} PUBLIC ${vcflib_LIBS} vcflib) target_link_libraries(${WFBIN} PUBLIC ${vcflib_LIBS} ${WFALIB}) endforeach(WFBIN ${BINS}) install(TARGETS ${BINS} RUNTIME DESTINATION ${CMAKE_INSTALL_BINDIR}) # ---- Copy scripts foreach(SCRIPT ${SCRIPTS}) install(PROGRAMS ./scripts/${SCRIPT} DESTINATION ${CMAKE_INSTALL_BINDIR} RENAME ${SCRIPT}) endforeach(SCRIPT ${SCRIPTS}) endif() # ---- Python bindings - mostly for testing at this stage pybind11_add_module(pyvcflib "${CMAKE_SOURCE_DIR}/src/pythonffi.cpp") add_dependencies(pyvcflib ${vcflib_DEPS}) target_link_libraries(pyvcflib PUBLIC vcflib ${vcflib_LIBS} ${WFALIB}) install(TARGETS pyvcflib LIBRARY DESTINATION ${CMAKE_INSTALL_LIBDIR}) # ---- Test enable_testing() function(add_pytest TEST_FILE) add_test( NAME ${TEST_FILE} COMMAND python3 tests/${TEST_FILE}.py WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/test ) SET_TESTS_PROPERTIES(${TEST_FILE} PROPERTIES ENVIRONMENT "LSAN_OPTIONS=suppressions=../test/libasan-suppress.txt;PYTHONPATH=${PROJECT_SOURCE_DIR}/build;;LD_LIBRARY_PATH=$ENV{LIBRARY_PATH}") endfunction() function(add_pydoctest TEST_FILE) add_test( NAME ${TEST_FILE} COMMAND python3 -m doctest -o NORMALIZE_WHITESPACE -o REPORT_UDIFF pytest/${TEST_FILE}.md WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/test ) SET_TESTS_PROPERTIES(${TEST_FILE} # PROPERTIES ENVIRONMENT "ASAN_OPTIONS=detect_leaks=1:symbolize=1;LSAN_OPTIONS=verbosity=2:log_threads=1:suppressions=../test/libasan-suppress.txt") PROPERTIES ENVIRONMENT "LSAN_OPTIONS=suppressions=../test/libasan-suppress.txt;PYTHONPATH=${PROJECT_SOURCE_DIR}/build:${PROJECT_SOURCE_DIR}/test/pytest") endfunction() function(add_doctest TEST_FILE) add_test( NAME ${TEST_FILE} COMMAND python3 -m doctest -o NORMALIZE_WHITESPACE -o REPORT_UDIFF ../${TEST_FILE}.md WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/test ) endfunction() function(add_pydoctest_fullname TEST_FILE) add_test( NAME ${TEST_FILE} COMMAND python3 -m doctest -o NORMALIZE_WHITESPACE -o REPORT_UDIFF ${TEST_FILE} WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/test ) endfunction() if (ZIG_TEST) # currently disabled function(add_zigtest) add_test( NAME zigvcf COMMAND zig build test WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR}/src/zig ) endfunction() add_zigtest() endif(ZIG_TEST) add_pytest(realign) add_pydoctest(pyvcflib) add_pydoctest(vcflib-api) add_pydoctest(vcf2tsv) add_pydoctest(vcfallelicprimitives) add_pydoctest(vcfwave) add_pydoctest(vcffilter) if (ZIG) add_pydoctest(vcfcreatemulti) endif (ZIG) add_pydoctest(vcfnulldotslashdot) add_doctest(doc/vcfintersect) # ---- Build docs # # Generates man pages for the python doctests. Don't need # to run every time so it is a separate command. For pandoc logic see # https://www.howtogeek.com/682871/how-to-create-a-man-page-on-linux/ # # cmake --build . --target man ; cmake --install . find_program(PANDOC pandoc) set(pytest vcfnulldotslashdot vcfallelicprimitives vcfwave) # vcfcreatemulti) if (PANDOC) # note the option ALL which allows to build the docs together with the application add_custom_target( man WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR} COMMAND ruby ./test/scripts/bin2md.rb --man test/scripts/bin2md-template.erb COMMAND ruby ./test/scripts/bin2md.rb --man --index # overwrite markdown from tests COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfnulldotslashdot.md ./doc/vcfnulldotslashdot.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfallelicprimitives.md ./doc/vcfallelicprimitives.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfwave.md ./doc/vcfwave.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfcreatemulti.md ./doc/vcfcreatemulti.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcflib-api.md ./doc/vcflib-api.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/pyvcflib.md ./doc/pyvcflib.md # generate man pages from markdown COMMAND ruby ./test/scripts/md2man # regenerate to allow for URLs in markdown docs COMMAND ruby ./test/scripts/bin2md.rb test/scripts/bin2md-template.erb COMMAND ruby ./test/scripts/bin2md.rb --index COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfnulldotslashdot.md ./doc/vcfnulldotslashdot.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfallelicprimitives.md ./doc/vcfallelicprimitives.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfwave.md ./doc/vcfwave.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcfcreatemulti.md ./doc/vcfcreatemulti.md # Documented test cases for Python bindings COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/pyvcflib.md ./doc/pyvcflib.md COMMAND ${CMAKE_COMMAND} -E copy ./test/pytest/vcflib-api.md ./doc/vcflib-api.md ) else (PANDOC) message("Pandoc needs to be installed to generate the man pages") endif (PANDOC) # ---- Install install(TARGETS vcflib ARCHIVE DESTINATION ${CMAKE_INSTALL_BINDIR}) #install(TARGETS ${WFALIB} ARCHIVE DESTINATION ${CMAKE_INSTALL_BINDIR}) install(FILES ${INCLUDES} DESTINATION include/vcflib) install(DIRECTORY ${CMAKE_SOURCE_DIR}/man/ DESTINATION ${CMAKE_INSTALL_PREFIX}/man/man1)