# ===========================================================================
# 
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#               National Center for Biotechnology Information
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#  This software/database is a "United States Government Work" under the
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#  warranties of performance, merchantability or fitness for any particular
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# ===========================================================================
# 
# 
from ctypes import c_char, c_int32, c_uint32, c_int64, c_void_p
from . import NGS

from .String import getNGSString, getNGSValue
from .Refcount import Refcount

from .Alignment import Alignment


# Represents a single cell of a sparse 2D matrix with Reference coordinates on one axis
# and stacked Alignments on the other axis

class PileupEvent(Refcount):

    # ----------------------------------------------------------------------
    # Reference
    
    def getMappingQuality(self):
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetMappingQuality, c_int32)

    # ----------------------------------------------------------------------
    # Alignment        
        
    def getAlignmentId(self):
        return getNGSString(self, NGS.lib_manager.PY_NGS_PileupEventGetAlignmentId)

    def getAlignmentPosition(self):
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetAlignmentPosition, c_int64)

    def getFirstAlignmentPosition(self):
        """
        :returns: the position of this Alignment's first event in Reference coordinates
        """
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetFirstAlignmentPosition, c_int64)

    def getLastAlignmentPosition(self):
        """
        :returns: the position of this Alignment's last event in INCLUSIVE Reference coordinates
        """
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetLastAlignmentPosition, c_int64)

    # ----------------------------------------------------------------------
    # event details        

    match                       = 0
    mismatch                    = 1
    deletion = 2
    
    # an insertion cannot be represented in reference coordinate
    # space ( so no insertion event can be directly represented ),
    # but it can occur before a match or mismatch event.
    # insertion is represented as a bit
    insertion                   = 0x08
    
    # insertions into the reference
    insertion_before_match      = insertion | match
    insertion_before_mismatch   = insertion | mismatch
    
    # simultaneous insertion and deletion,
    # a.k.a. a replacement
    insertion_before_deletion   = insertion | deletion
    replacement                 = insertion_before_deletion
    
    # additional modifier bits - may be added to any event above
    alignment_start             = 0x80
    alignment_stop              = 0x40
    alignment_minus_strand      = 0x20


    def getEventType(self):
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetEventType, c_uint32)

    def getAlignmentBase(self):
        """
        :returns: retrieves base aligned at current Reference position
        :throws: ErrorMsg if event is an insertion or deletion
        """
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetAlignmentBase, c_char).decode("utf-8")

    def getAlignmentQuality(self):
        """
        :returns: retrieves base aligned at current Reference position
        :throws: ErrorMsg if event is an insertion or deletion
        """
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetAlignmentQuality, c_char).decode("utf-8")

    def getInsertionBases(self):
        """
        :returns: bases corresponding to insertion event
        """
        return getNGSString(self, NGS.lib_manager.PY_NGS_PileupEventGetInsertionBases)

    def getInsertionQualities(self):
        """
        :returns: qualities corresponding to insertion event
        """
        return getNGSString(self, NGS.lib_manager.PY_NGS_PileupEventGetInsertionQualities)

    def getEventRepeatCount(self):
        """
        :returns: the number of times this event repeats, i.e. the distance to the first reference position yielding a different event type for this alignment
        """
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetEventRepeatCount, c_uint32)

    # EventIndelType

    normal_indel              = 0

    # introns behave like deletions
    # (i.e. can retrieve deletion count),
    # "_plus" and "_minus" signify direction
    # of transcription if known
    intron_plus               = 1
    intron_minus              = 2
    intron_unknown            = 3

    # overlap is reported as an insertion,
    # but is actually an overlap in the read
    # inherent in technology like Complete Genomics
    read_overlap              = 4

    # gap is reported as a deletion,
    # but is actually a gap in the read
    # inherent in technology like Complete Genomics
    read_gap                  = 5


    def getEvenIndeltType(self):
        return getNGSValue(self, NGS.lib_manager.PY_NGS_PileupEventGetEventIndelType, c_uint32)