| Database |
InterPro |
| Accession |
IPR001064; Crystallin (matches 132 proteins) |
| Name |
Crystallin |
| Type |
Domain
 |
| Dates |
08-OCT-1999 (created)
05-DEC-2000 (last modified) |
| Signatures |
PS00225; CRYSTALLIN_BETAGAMMA
(1586 proteins)
PR01367; BGCRYSTALLIN
(102 proteins)
PF00030; crystall
(113 proteins)
SM00247; XTALbg
(129 proteins)
|
Abstract
 |
Crystallins are the dominant structural components of the eye lens. Among the
different type of crystallins, the beta and gamma crystallins form a family of
related proteins [1, 2]. Structurally, beta and gamma crystallins
are composed of two similar domains which, in turn, are each composed of two similar
motifs with the two domains connected by a short connecting peptide. Each motif,
which is about forty amino acid residues long, is folded in a distinctive
'Greek key' pattern. |
| Examples |
- P02966 DESS_MYXXA: A calcium-binding protein from the sporulating bacterium Myxococcus xanthusa forms a major part of the spore coat
- P46058 EDSP_CYNPY
- P09353 SR3A_PHYPO: Spherulin 3a from the slime mold Physarum polycephalum. Spherulin 3a is a development specific protein synthesized in response to various kinds of stress leading to encystment and dormancy. The sequence of Spherulin 3a consists of two 'Greek key' motifs [3]
- P06504 CRBS_BOVIN
- Q91314 CB12_RANCA
- P07317 CRBA_RANTE
View examples
|
| References |
-
Wistow G.J., Piatigorsky J.
Lens crystallins: the evolution and expression of proteins for a highly specialized tissue.
Annu. Rev. Biochem. 57: 479-504(1988).
[MEDLINE:89024580]
[PUB00000056]
-
Lubsen N.H., Aarts H.J.M., Schoenmakers J.G.G.
The evolution of lenticular proteins: the beta- and gamma-crystallin super gene family.
Prog. Biophys. Mol. Biol. 51: 47-76(1988).
[MEDLINE:89113769]
[PUB00004933]
-
Wistow G.
Evolution of a protein superfamily: relationships between vertebrate lens crystallins and microorganism dormancy proteins.
J. Mol. Evol. 30: 140-145(1990).
[MEDLINE:90189184]
[PUB00003409]
|
| Database links |
PROSITE doc; PDOC00197
Blocks; IPB001064
|
|
Matches
|
Table all Graphical all Condensed graphical view |
