P00750
type: Protein
reviewed: true
created: 1986-07-21
modified: 2010-10-05
version: 160
mnemonic: TPA_HUMAN
mnemonic: UROT_HUMAN
replaces: A8K022
replaces: B2R8E8
replaces: Q15103
replaces: Q503B0
replaces: Q6PJA5
replaces: Q7Z7N2
replaces: Q86YK8
replaces: Q9BU99
replaces: Q9BZW1
citation: http://purl.uniprot.org/citations/6337343
citation: http://purl.uniprot.org/citations/6089198
citation: http://purl.uniprot.org/citations/3009482
citation: http://purl.uniprot.org/citations/3090401
citation: http://purl.uniprot.org/citations/2824147
citation: http://purl.uniprot.org/citations/3133640
citation: http://purl.uniprot.org/citations/2107528
citation: 50303037353000B
citation: 50303037353000D
citation: http://purl.uniprot.org/citations/14702039
citation: 5030303735300011
citation: 5030303735300013
citation: 5030303735300015
citation: http://purl.uniprot.org/citations/15489334
citation: http://purl.uniprot.org/citations/3161893
citation: http://purl.uniprot.org/citations/1368681
citation: http://purl.uniprot.org/citations/6682760
citation: http://purl.uniprot.org/citations/6433976
citation: http://purl.uniprot.org/citations/6572897
citation: 5030303735300022
citation: http://purl.uniprot.org/citations/2513186
citation: http://purl.uniprot.org/citations/1900431
citation: http://purl.uniprot.org/citations/1645336
citation: http://purl.uniprot.org/citations/11384978
citation: http://purl.uniprot.org/citations/14759258
citation: http://purl.uniprot.org/citations/2558718
citation: http://purl.uniprot.org/citations/1901789
citation: http://purl.uniprot.org/citations/1762144
citation: http://purl.uniprot.org/citations/1310033
citation: http://purl.uniprot.org/citations/1602484
citation: http://purl.uniprot.org/citations/7582899
citation: http://purl.uniprot.org/citations/8613982
citation: http://purl.uniprot.org/citations/9305622
conflicting sequence: 5030303735300050
conflicting sequence: 5030303735300051
conflicting sequence: 5030303735300052
conflicting sequence: 5030303735300053
conflicting sequence: 5030303735300054
recommended name: 5030303735300055
alternative name: 5030303735300056
alternative name: 5030303735300057
enzyme: http://purl.uniprot.org/enzyme/3.4.21.68
component: 5030303735300058
component: 503030373530005A
organism: http://purl.uniprot.org/taxonomy/9606
isolated from: http://purl.uniprot.org/tissues/614
isolated from: http://purl.uniprot.org/tissues/345
isolated from: http://purl.uniprot.org/tissues/1082
isolated from: http://purl.uniprot.org/tissues/1030
isolated from: http://purl.uniprot.org/tissues/95
isolated from: http://purl.uniprot.org/tissues/799
isolated from: http://purl.uniprot.org/tissues/934
encoded by: PLAT
annotation: 5030303735300064
annotation: 5030303735300065
annotation: 5030303735300066
annotation: 5030303735300069
annotation: 503030373530006B
annotation: 503030373530006C
annotation: 503030373530006D
annotation: 5030303735300071
annotation: 5030303735300073
annotation: 5030303735300075
annotation: 5030303735300077

http://purl.uniprot.org/citations/6337343
type: Journal Citation
title: Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.
author: Pennica D.
author: Holmes W.E.
author: Kohr W.J.
author: Harkins R.N.
author: Vehar G.A.
author: Ward C.A.
author: Bennett W.F.
author: Yelverton E.
author: Seeburg P.H.
author: Heyneker H.L.
author: Goeddel D.V.
author: Collen D.
date: 1983
name: Nature
volume: 301
pages: 214-221

503030373530001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
context: Melanoma

Melanoma
type: Tissue

http://purl.uniprot.org/citations/6089198
type: Journal Citation
title: The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.
author: Ny T.
author: Elgh F.
author: Lund B.
date: 1984
name: Proc. Natl. Acad. Sci. U.S.A.
volume: 81
pages: 5355-5359

503030373530003
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

http://purl.uniprot.org/citations/3009482
type: Journal Citation
title: The human tissue plasminogen activator gene.
author: Friezner Degen S.J.
author: Rajput B.
author: Reich E.
date: 1986
name: J. Biol. Chem.
volume: 261
pages: 6972-6985

503030373530004
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

http://purl.uniprot.org/citations/3090401
type: Journal Citation
title: Cloning of cDNA coding for human tissue-type plasminogen activator and its expression in Escherichia coli.
author: Harris T.J.
author: Patel T.
author: Marston F.A.
author: Little S.
author: Emtage J.S.
author: Opdenakker G.
author: Volckaert G.
author: Rombauts W.
author: Billiau A.
author: Somer P.
date: 1986
name: Mol. Biol. Med.
volume: 3
pages: 279-292

503030373530005
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

http://purl.uniprot.org/citations/2824147
type: Journal Citation
title: Expression of human uterine tissue-type plasminogen activator in mouse cells using BPV vectors.
author: Reddy V.B.
author: Garramone A.J.
author: Sasak H.
author: Wei C.-M.
author: Watkins P.
author: Galli J.
author: Hsiung N.
date: 1987
name: DNA
volume: 6
pages: 461-472

503030373530006
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

http://purl.uniprot.org/citations/3133640
type: Journal Citation
title: Nucleotide sequence of the tissue-type plasminogen activator cDNA from human fetal lung cells.
author: Sasaki H.
author: Saito Y.
author: Hayashi M.
author: Otsuka K.
author: Niwa M.
date: 1988
name: Nucleic Acids Res.
volume: 16
pages: 5695

503030373530007
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
context: Fetal lung

Fetal lung
type: Tissue

http://purl.uniprot.org/citations/2107528
type: Journal Citation
title: Variant tissue-type plasminogen activator (PLAT) cDNA obtained from human endothelial cells.
author: Siebert P.D.
author: Fong K.
date: 1990
name: Nucleic Acids Res.
volume: 18
pages: 1086

503030373530009
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
context: Umbilical vein

Umbilical vein
type: Tissue

50303037353000B
type: Submission Citation
title: A brain-type plasminogen activator.
author: Dou D.
date: 2000-04
submitted to: EMBL/GenBank/DDBJ

50303037353000C
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)

50303037353000D
type: Submission Citation
title: cDNA of tissue plasminogen activator.
author: Liu Y.
author: Xu L.
author: Zeng Y.
author: He X.
date: 2003-01
submitted to: EMBL/GenBank/DDBJ

50303037353000E
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

http://purl.uniprot.org/citations/14702039
type: Journal Citation
title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
author: Ota T.
author: Suzuki Y.
author: Nishikawa T.
author: Otsuki T.
author: Sugiyama T.
author: Irie R.
author: Wakamatsu A.
author: Hayashi K.
author: Sato H.
author: Nagai K.
author: Kimura K.
author: Makita H.
author: Sekine M.
author: Obayashi M.
author: Nishi T.
author: Shibahara T.
author: Tanaka T.
author: Ishii S.
author: Yamamoto J.
author: Saito K.
author: Kawai Y.
author: Isono Y.
author: Nakamura Y.
author: Nagahari K.
author: Murakami K.
author: Yasuda T.
author: Iwayanagi T.
author: Wagatsuma M.
author: Shiratori A.
author: Sudo H.
author: Hosoiri T.
author: Kaku Y.
author: Kodaira H.
author: Kondo H.
author: Sugawara M.
author: Takahashi M.
author: Kanda K.
author: Yokoi T.
author: Furuya T.
author: Kikkawa E.
author: Omura Y.
author: Abe K.
author: Kamihara K.
author: Katsuta N.
author: Sato K.
author: Tanikawa M.
author: Yamazaki M.
author: Ninomiya K.
author: Ishibashi T.
author: Yamashita H.
author: Murakawa K.
author: Fujimori K.
author: Tanai H.
author: Kimata M.
author: Watanabe M.
author: Hiraoka S.
author: Chiba Y.
author: Ishida S.
author: Ono Y.
author: Takiguchi S.
author: Watanabe S.
author: Yosida M.
author: Hotuta T.
author: Kusano J.
author: Kanehori K.
author: Takahashi-Fujii A.
author: Hara H.
author: Tanase T.-O.
author: Nomura Y.
author: Togiya S.
author: Komai F.
author: Hara R.
author: Takeuchi K.
author: Arita M.
author: Imose N.
author: Musashino K.
author: Yuuki H.
author: Oshima A.

50303037353000F
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
context: Testis

Testis
type: Tissue

5030303735300011
type: Submission Citation
title: Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
author: Kalnine N.
author: Chen X.
author: Rolfs A.
author: Halleck A.
author: Hines L.
author: Eisenstein S.
author: Koundinya M.
author: Raphael J.
author: Moreira D.
author: Kelley T.
author: LaBaer J.
author: Lin Y.
author: Phelan M.
author: Farmer A.
date: 2003-05
submitted to: EMBL/GenBank/DDBJ

5030303735300012
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)

5030303735300013
type: Submission Citation
group: SeattleSNPs variation discovery resource
date: 2003-05
submitted to: EMBL/GenBank/DDBJ

5030303735300014
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: VARIANTS ASP-34; SER-136; THR-146 AND TRP-164

5030303735300015
type: Submission Citation
author: Mural R.J.
author: Istrail S.
author: Sutton G.G.
author: Florea L.
author: Halpern A.L.
author: Mobarry C.M.
author: Lippert R.
author: Walenz B.
author: Shatkay H.
author: Dew I.
author: Miller J.R.
author: Flanigan M.J.
author: Edwards N.J.
author: Bolanos R.
author: Fasulo D.
author: Halldorsson B.V.
author: Hannenhalli S.
author: Turner R.
author: Yooseph S.
author: Lu F.
author: Nusskern D.R.
author: Shue B.C.
author: Zheng X.H.
author: Zhong F.
author: Delcher A.L.
author: Huson D.H.
author: Kravitz S.A.
author: Mouchard L.
author: Reinert K.
author: Remington K.A.
author: Clark A.G.
author: Waterman M.S.
author: Eichler E.E.
author: Adams M.D.
author: Hunkapiller M.W.
author: Myers E.W.
author: Venter J.C.
date: 2005-09
submitted to: EMBL/GenBank/DDBJ

5030303735300016
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

http://purl.uniprot.org/citations/15489334
type: Journal Citation
title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
group: The MGC Project Team
date: 2004
name: Genome Res.
volume: 14
pages: 2121-2127

5030303735300017
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
context: Brain
context: Placenta
context: Skin

Brain
type: Tissue

Placenta
type: Tissue

Skin
type: Tissue

http://purl.uniprot.org/citations/3161893
type: Journal Citation
title: Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.
author: Fisher R.
author: Waller E.K.
author: Grossi G.
author: Thompson D.
author: Tizard R.
author: Schleuning W.-D.
date: 1985
name: J. Biol. Chem.
volume: 260
pages: 11223-11230

503030373530001B
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36

http://purl.uniprot.org/citations/1368681
type: Journal Citation
title: Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells.
author: Itagaki Y.
author: Yasuda H.
author: Morinaga T.
author: Mitsuda S.
author: Higashio K.
date: 1991
name: Agric. Biol. Chem.
volume: 55
pages: 1225-1232

503030373530001C
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] OF 31-562

http://purl.uniprot.org/citations/6682760
type: Journal Citation
title: Purification and characterization of a melanoma cell plasminogen activator.
author: Wallen P.
author: Pohl G.
author: Bergsdorf N.
author: Raanby M.
author: Ny T.
author: Joernvall H.
date: 1983
name: Eur. J. Biochem.
volume: 132
pages: 681-686

503030373530001D
type: Citation Statement
scope: PROTEIN SEQUENCE OF 33-52 AND 311-330
context: Melanoma

Melanoma
type: Tissue

http://purl.uniprot.org/citations/6433976
type: Journal Citation
title: Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.
author: Pohl G.
author: Kaellstroem M.
author: Bergsdorf N.
author: Wallen P.
author: Joernvall H.
date: 1984
name: Biochemistry
volume: 23
pages: 3701-3707

503030373530001F
type: Citation Statement
scope: PROTEIN SEQUENCE OF 36-562
context: Melanoma

Melanoma
type: Tissue

http://purl.uniprot.org/citations/6572897
type: Journal Citation
title: Isolation of cDNA sequences coding for a part of human tissue plasminogen activator.
author: Edlund T.
author: Ny T.
author: Raanby M.
author: Heden L.-O.
author: Palm G.
author: Holmgren E.
author: Josephson S.
date: 1983
name: Proc. Natl. Acad. Sci. U.S.A.
volume: 80
pages: 349-352

5030303735300021
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] OF 251-358

5030303735300022
type: Submission Citation
author: Jalah R.
author: Pavlakis G.N.
author: Felber B.J.
date: 2007-07
submitted to: UniProtKB

5030303735300023
type: Citation Statement
scope: PARTIAL PROTEIN SEQUENCE
scope: SIGNAL SEQUENCE CLEAVAGE SITE

http://purl.uniprot.org/citations/2513186
type: Journal Citation
title: Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells.
author: Pfeiffer G.
author: Schmidt M.
author: Strube K.-H.
author: Geyer R.
date: 1989
name: Eur. J. Biochem.
volume: 186
pages: 273-286

5030303735300024
type: Citation Statement
scope: STRUCTURE OF CARBOHYDRATES

http://purl.uniprot.org/citations/1900431
type: Journal Citation
title: Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain.
author: Harris R.J.
author: Leonard C.K.
author: Guzzetta A.W.
author: Spellman M.W.
date: 1991
name: Biochemistry
volume: 30
pages: 2311-2314

5030303735300025
type: Citation Statement
scope: GLYCOSYLATION AT THR-96

http://purl.uniprot.org/citations/1645336
type: Journal Citation
title: Disulfide pairing of the recombinant kringle-2 domain of tissue plasminogen activator produced in Escherichia coli.
author: Vlahos C.J.
author: Wilhelm O.G.
author: Hassell T.
author: Jaskunas S.R.
author: Bang N.U.
date: 1991
name: J. Biol. Chem.
volume: 266
pages: 10070-10072

5030303735300026
type: Citation Statement
scope: DISULFIDE BONDS IN KRINGLE 2

http://purl.uniprot.org/citations/11384978
type: Journal Citation
title: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.
author: Liu C.-X.
author: Li Y.
author: Obermoeller-McCormick L.M.
author: Schwartz A.L.
author: Bu G.
date: 2001
name: J. Biol. Chem.
volume: 276
pages: 28889-28896

5030303735300027
type: Citation Statement
scope: INTERACTION WITH LRP1B

http://purl.uniprot.org/citations/14759258
type: Journal Citation
title: An unappreciated role for RNA surveillance.
author: Hillman R.T.
author: Green R.E.
author: Brenner S.E.
date: 2004
name: Genome Biol.
volume: 5
pages: R8.1-R8.16

5030303735300028
type: Citation Statement
scope: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)

http://purl.uniprot.org/citations/2558718
type: Journal Citation
title: 1H NMR structural characterization of a recombinant kringle 2 domain from human tissue-type plasminogen activator.
author: Byeon I.-J.L.
author: Kelley R.F.
author: Llinas M.
date: 1989
name: Biochemistry
volume: 28
pages: 9350-9360

5030303735300029
type: Citation Statement
scope: STRUCTURE BY NMR OF KRINGLE 2

http://purl.uniprot.org/citations/1901789
type: Journal Citation
title: Kringle-2 domain of the tissue-type plasminogen activator. 1H-NMR assignments and secondary structure.
author: Byeon I.-J.L.
author: Kelley R.F.
author: Llinas M.
date: 1991
name: Eur. J. Biochem.
volume: 197
pages: 155-165

503030373530002A
type: Citation Statement
scope: STRUCTURE BY NMR OF KRINGLE 2

http://purl.uniprot.org/citations/1762144
type: Journal Citation
title: Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.
author: Byeon I.-J.L.
author: Llinas M.
date: 1991
name: J. Mol. Biol.
volume: 222
pages: 1035-1051

503030373530002B
type: Citation Statement
scope: STRUCTURE BY NMR OF KRINGLE 2

http://purl.uniprot.org/citations/1310033
type: Journal Citation
title: Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
author: de Vos A.
author: Ultsch M.H.
author: Kelley R.F.
author: Padmanabhan K.
author: Tulinskly A.
author: Westbrook M.L.
author: Kossiakof A.A.
date: 1992
name: Biochemistry
volume: 31
pages: 270-279

503030373530002C
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF KRINGLE 2

http://purl.uniprot.org/citations/1602484
type: Journal Citation
title: Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.
author: Downing A.K.
author: Driscoll P.C.
author: Harvey T.S.
author: Dudgeon T.J.
author: Smith B.O.
author: Baron M.
author: Campbell I.D.
date: 1992
name: J. Mol. Biol.
volume: 225
pages: 821-833

503030373530002D
type: Citation Statement
scope: STRUCTURE BY NMR OF 38-85

http://purl.uniprot.org/citations/7582899
type: Journal Citation
title: The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
author: Smith B.O.
author: Downing A.K.
author: Driscoll P.C.
author: Dudgeon T.J.
author: Campbell I.D.
date: 1995
name: Structure
volume: 3
pages: 823-833

503030373530002E
type: Citation Statement
scope: STRUCTURE BY NMR OF 36-126

http://purl.uniprot.org/citations/8613982
type: Journal Citation
title: The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator.
author: Lamba D.
author: Bauer M.
author: Huber R.
author: Fischer S.
author: Rudolph R.
author: Kohnert U.
author: Bode W.
date: 1996
name: J. Mol. Biol.
volume: 258
pages: 117-135

503030373530002F
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF CATALYTIC DOMAIN

http://purl.uniprot.org/citations/9305622
type: Journal Citation
title: Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
author: Renatus M.
author: Engh R.A.
author: Stubbs M.T.
author: Huber R.
author: Fischer S.
author: Kohnert U.
author: Bode W.
date: 1997
name: EMBO J.
volume: 16
pages: 4797-4805

5030303735300030
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF CATALYTIC DOMAIN

Tissue plasminogen Activator
type: Resource
comment: Wikipedia; Tissue plasminogen activator entry

plat
type: Resource
comment: SeattleSNPs

http://shmpd.bii.a-star.edu.sg/gene.php
type: Resource
comment: SHMPD; The Singapore human mutation and polymorphism database

index.jsp
type: Resource
comment: Activase; Clinical information on Activase

Retavase PI.pdf
type: Resource
comment: Retavase; Clinical information on Retavase

AAB59510.1
type: Nucleotide Resource
database: EMBL
located on: L00153
located on: L00141
located on: L00142
located on: L00143
located on: L00144
located on: L00145
located on: L00146
located on: L00147
located on: L00148
located on: L00149
located on: L00150
located on: L00151
citation: http://purl.uniprot.org/citations/6089198

AAA98809.1
type: Nucleotide Resource
database: EMBL
located on: K03021

AAA60111.1
type: Nucleotide Resource
database: EMBL
located on: M15518

AAA36800.1
type: Nucleotide Resource
database: EMBL
located on: M18182

CAA30302.1
type: Nucleotide Resource
database: EMBL
located on: X07393

CAA31489.1
type: Nucleotide Resource
database: EMBL
located on: X13097
citation: http://purl.uniprot.org/citations/2107528

AAK11956.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/AF260825
citation: 50303037353000B

AAO34406.1
type: Nucleotide Resource
database: EMBL
located on: AY221101
citation: 50303037353000D

BAF82076.1
type: Nucleotide Resource
database: EMBL
located on: AK289387

BAF83264.1
type: Nucleotide Resource
database: EMBL
located on: AK290575

BAG36145.1
type: Nucleotide Resource
database: EMBL
located on: AK313342

AAP35709.1
type: Nucleotide Resource
database: EMBL
located on: BT007060

AAP34246.1
type: Nucleotide Resource
database: EMBL
located on: AY291060

EAW63235.1
type: Nucleotide Resource
database: EMBL
located on: CH471080

EAW63233.1
type: Nucleotide Resource
database: EMBL
located on: CH471080

AAH02795.3
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC002795

AAH07231.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC007231

AAH13968.3
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC013968

AAH18636.3
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC018636

AAH95403.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC095403
citation: http://purl.uniprot.org/citations/15489334

AAA61213.1
type: Nucleotide Resource
database: EMBL
located on: M11890
located on: M11889

BAA00881.1
type: Nucleotide Resource
database: EMBL
located on: D01096

CAA23833.1
type: Nucleotide Resource
database: EMBL
located on: V00570

IPI00019590
type: Resource
database: IPI

IPI00479511
type: Resource
database: IPI

IPI00910450
type: Resource
database: IPI

IPI00953228
type: Resource
database: IPI

UKHUT
type: Resource
database: PIR
comment: A94004

I38098
type: Resource
database: PIR

NP 000921.1
type: Resource
database: RefSeq

NP 127509.1
type: Resource
database: RefSeq

Hs.491582
type: Resource
database: UniGene

1A5H
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.90

5030303735300031
type: Structure Mapping Statement
chain: A/B=311-562
chain: C/D=298-304

1BDA
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.35

5030303735300032
type: Structure Mapping Statement
chain: A/B=298-562

1PK2
type: Structure Resource
database: PDB
method: NMR Spectroscopy

5030303735300033
type: Structure Mapping Statement
chain: A=209-298

1PML
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.38

5030303735300034
type: Structure Mapping Statement
chain: A/B/C=213-298

1RTF
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.30

5030303735300035
type: Structure Mapping Statement
chain: B=311-562

1TPG
type: Structure Resource
database: PDB
method: NMR Spectroscopy

5030303735300036
type: Structure Mapping Statement
chain: A=36-126

1TPK
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.40

5030303735300037
type: Structure Mapping Statement
chain: A/B/C=211-298

1TPM
type: Structure Resource
database: PDB
method: NMR Spectroscopy

5030303735300038
type: Structure Mapping Statement
chain: A=36-85

1TPN
type: Structure Resource
database: PDB
method: NMR Spectroscopy

5030303735300039
type: Structure Mapping Statement
chain: A=36-85

1A5H
type: Resource
database: PDBsum

1BDA
type: Resource
database: PDBsum

1PK2
type: Resource
database: PDBsum

1PML
type: Resource
database: PDBsum

1RTF
type: Resource
database: PDBsum

1TPG
type: Resource
database: PDBsum

1TPK
type: Resource
database: PDBsum

1TPM
type: Resource
database: PDBsum

1TPN
type: Resource
database: PDBsum

P00750
type: Resource
database: ProteinModelPortal

P00750
type: Resource
database: SMR
comment: 126-210, 174-299, 212-334

P00750
type: Resource
database: STRING

S01.232
type: Resource
database: MEROPS

P00750
type: Resource
database: GlycoSuiteDB

P00750
type: Resource
database: PRIDE

ENST00000220809
type: Transcript Resource
database: Ensembl
translated to: ENSP00000220809
transcribed from: ENSG00000104368

http://purl.uniprot.org/geneid/5327
type: Resource
database: GeneID

hsa:5327
type: Resource
database: KEGG

uc003xos.2
type: Resource
database: UCSC
comment: human

uc003xot.2
type: Resource
database: UCSC
comment: human

uc010lxf.1
type: Resource
database: UCSC
comment: human

http://purl.uniprot.org/ctd/5327
type: Resource
database: CTD

GC08M042050
type: Resource
database: GeneCards

HIX0007476
type: Resource
database: H-InvDB

http://purl.uniprot.org/hgnc/9051
type: Resource
database: HGNC
comment: PLAT

http://purl.uniprot.org/hpa/CAB009335
type: Resource
database: HPA

HPA003412
type: Resource
database: HPA

http://purl.uniprot.org/mim/173370
type: Resource
database: MIM
comment: gene

PA33381
type: Resource
database: PharmGKB

prNOG16610
type: Resource
database: eggNOG

HBG008633
type: Resource
database: HOVERGEN

P00750
type: Resource
database: InParanoid

TCGLRQY
type: Resource
database: OMA

EOG9TQPVK
type: Resource
database: OrthoDB

P00750
type: Resource
database: PhylomeDB

http://purl.uniprot.org/brenda/3.4.21.68
type: Resource
database: BRENDA
comment: 247

amb2 neutrophils pathway
type: Resource
database: Pathway_Interaction_DB
comment: amb2 Integrin signaling

REACT_16888
type: Resource
database: Reactome
comment: Signaling by PDGF

REACT 604
type: Resource
database: Reactome
comment: Hemostasis

DB00009
type: Resource
database: DrugBank
comment: Alteplase

DB00513
type: Resource
database: DrugBank
comment: Aminocaproic Acid

DB00029
type: Resource
database: DrugBank
comment: Anistreplase

DB01088
type: Resource
database: DrugBank
comment: Iloprost

DB00015
type: Resource
database: DrugBank
comment: Reteplase

DB00031
type: Resource
database: DrugBank
comment: Tenecteplase

DB00302
type: Resource
database: DrugBank
comment: Tranexamic Acid

DB00013
type: Resource
database: DrugBank
comment: Urokinase

http://purl.uniprot.org/nextbio/20622
type: Resource
database: NextBio

P00750
type: Resource
database: PMAP-CutDB

P00750
type: Resource
database: ArrayExpress

P00750
type: Resource
database: Bgee

P00750
type: Resource
database: Genevestigator

ENSG00000104368
type: Resource
database: GermOnline
comment: Homo sapiens

IPR016060
type: Resource
database: InterPro
comment: Complement_control_module

IPR006209
type: Resource
database: InterPro
comment: EGF

IPR006210
type: Resource
database: InterPro
comment: EGF-like

IPR013032
type: Resource
database: InterPro
comment: EGF-like_reg_CS

IPR000742
type: Resource
database: InterPro
comment: EGF_3

IPR000083
type: Resource
database: InterPro
comment: Fibrnctn1

IPR000001
type: Resource
database: InterPro
comment: Kringle

IPR013806
type: Resource
database: InterPro
comment: Kringle-like

IPR018056
type: Resource
database: InterPro
comment: Kringle_CS

IPR018114
type: Resource
database: InterPro
comment: Peptidase_S1/S6_AS

IPR001254
type: Resource
database: InterPro
comment: Peptidase_S1_S6

IPR001314
type: Resource
database: InterPro
comment: Peptidase_S1A

IPR009003
type: Resource
database: InterPro
comment: Ser/Cys_Pept_Trypsin-like

G3DSA:2.10.70.10
type: Resource
database: Gene3D
comment: Complement_control_module

503030373530003A
type: Domain Assignment Statement
hits: 1

G3DSA:2.40.20.10
type: Resource
database: Gene3D
comment: Kringle

503030373530003B
type: Domain Assignment Statement
hits: 2

PF00008
type: Resource
database: Pfam
comment: EGF

503030373530003C
type: Domain Assignment Statement
hits: 1

PF00039
type: Resource
database: Pfam
comment: fn1

503030373530003D
type: Domain Assignment Statement
hits: 1

PF00051
type: Resource
database: Pfam
comment: Kringle

503030373530003E
type: Domain Assignment Statement
hits: 2

PF00089
type: Resource
database: Pfam
comment: Trypsin

503030373530003F
type: Domain Assignment Statement
hits: 1

PR00722
type: Resource
database: PRINTS
comment: CHYMOTRYPSIN

SM00181
type: Resource
database: SMART
comment: EGF

5030303735300040
type: Domain Assignment Statement
hits: 1

SM00058
type: Resource
database: SMART
comment: FN1

5030303735300041
type: Domain Assignment Statement
hits: 1

SM00130
type: Resource
database: SMART
comment: KR

5030303735300042
type: Domain Assignment Statement
hits: 2

SM00020
type: Resource
database: SMART
comment: Tryp_SPc

5030303735300043
type: Domain Assignment Statement
hits: 1

SSF57440
type: Resource
database: SUPFAM
comment: Kringle-like

5030303735300044
type: Domain Assignment Statement
hits: 2

SSF50494
type: Resource
database: SUPFAM
comment: Pept_Ser_Cys

5030303735300045
type: Domain Assignment Statement
hits: 1

PS00022
type: Resource
database: PROSITE
comment: EGF_1

5030303735300046
type: Domain Assignment Statement
hits: 1

PS01186
type: Resource
database: PROSITE
comment: EGF_2

5030303735300047
type: Domain Assignment Statement
hits: 1

PS50026
type: Resource
database: PROSITE
comment: EGF_3

5030303735300048
type: Domain Assignment Statement
hits: 1

PS01253
type: Resource
database: PROSITE
comment: FN1_1

5030303735300049
type: Domain Assignment Statement
hits: 1

PS51091
type: Resource
database: PROSITE
comment: FN1_2

503030373530004A
type: Domain Assignment Statement
hits: 1

PS00021
type: Resource
database: PROSITE
comment: KRINGLE_1

503030373530004B
type: Domain Assignment Statement
hits: 2

PS50070
type: Resource
database: PROSITE
comment: KRINGLE_2

503030373530004C
type: Domain Assignment Statement
hits: 2

PS50240
type: Resource
database: PROSITE
comment: TRYPSIN_DOM

503030373530004D
type: Domain Assignment Statement
hits: 1

PS00134
type: Resource
database: PROSITE
comment: TRYPSIN_HIS

503030373530004E
type: Domain Assignment Statement
hits: 1

PS00135
type: Resource
database: PROSITE
comment: TRYPSIN_SER

503030373530004F
type: Domain Assignment Statement
hits: 1

5030303735300055
type: Structured Name
full name: Tissue-type plasminogen activator
short name: t-PA
short name: t-plasminogen activator
short name: tPA
ec name: 3.4.21.68

5030303735300056
type: Structured Name
international nonproprietary name: Alteplase

5030303735300057
type: Structured Name
international nonproprietary name: Reteplase

5030303735300059
type: Structured Name
full name: Tissue-type plasminogen activator chain A

503030373530005B
type: Structured Name
full name: Tissue-type plasminogen activator chain B

PLAT
type: Gene

5030303735300064
type: Function Annotation
comment: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.

5030303735300065
type: Catalytic Activity Annotation
comment: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

5030303735300066
type: Subunit Annotation
comment: Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.

503030373530006C
type: Tissue Specificity Annotation
comment: Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

503030373530006D
type: Domain Annotation
comment: Both FN1 and one of the kringle domains are required for binding to fibrin.

5030303735300071
type: Domain Annotation
comment: Both FN1 and EGF-like domains are important for binding to LRP1.

5030303735300073
type: Domain Annotation
comment: The FN1 domain mediates binding to annexin A2.

5030303735300075
type: Domain Annotation
comment: The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.

5030303735300077
type: PTM Annotation
comment: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.

5030303735300078
type: PTM Annotation
comment: Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.

503030373530007C
type: PTM Annotation
comment: N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.

503030373530007D
type: PTM Annotation
comment: Characterization of O-linked glycan was studied in Bowes melanoma cell line.

503030373530007E
type: Disease Annotation
comment: Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.

503030373530007F
type: Pharmaceutical Annotation
comment: Available under the names Activase (Genentech) and Retavase (Centocor and Roche) [Retavase is a fragment of TPA that contains kringle 2 and the protease domain; it was also known as BM 06.022]. Used in Acute Myocardial Infarction (AMI), in Acute Ischemic Stroke (AIS) and Pulmonary Embolism (PE) to initiate fibrinolysis.

5030303735300080
type: Similarity Annotation
comment: Belongs to the peptidase S1 family.

5030303735300081
type: Similarity Annotation
comment: Contains 1 EGF-like domain.

5030303735300082
type: Similarity Annotation
comment: Contains 1 fibronectin type-I domain.

5030303735300083
type: Similarity Annotation
comment: Contains 2 kringle domains.

5030303735300084
type: Similarity Annotation
comment: Contains 1 peptidase S1 domain.

5030303735300086
type: Range
begin: 1
end: 22

5030303735300087
type: Range
begin: 23
end: 32

PRO_0000028349
type: Propeptide Annotation
comment: Removed by plasmin
range: 5030303735300088

5030303735300088
type: Range
begin: 33
end: 35

PRO_0000028350
type: Chain Annotation
comment: Tissue-type plasminogen activator
range: 5030303735300089

5030303735300089
type: Range
begin: 36
end: 562

PRO_0000028351
type: Chain Annotation
comment: Tissue-type plasminogen activator chain A
range: 503030373530008A

503030373530008A
type: Range
begin: 36
end: 310

PRO_0000028352
type: Chain Annotation
comment: Tissue-type plasminogen activator chain B
range: 503030373530008B

503030373530008B
type: Range
begin: 311
end: 562

503030373530008C
type: Domain Extent Annotation
comment: Fibronectin type-I
range: 503030373530008D

503030373530008D
type: Range
begin: 39
end: 81

503030373530008E
type: Domain Extent Annotation
comment: EGF-like
range: 503030373530008F

503030373530008F
type: Range
begin: 82
end: 120

5030303735300090
type: Domain Extent Annotation
comment: Kringle 1
range: 5030303735300091

5030303735300091
type: Range
begin: 127
end: 208

5030303735300092
type: Domain Extent Annotation
comment: Kringle 2
range: 5030303735300093

5030303735300093
type: Range
begin: 215
end: 296

5030303735300094
type: Domain Extent Annotation
comment: Peptidase S1
range: 5030303735300095

5030303735300095
type: Range
begin: 311
end: 561

5030303735300096
type: Region Annotation
comment: Important for binding to annexin A2
range: 5030303735300097

5030303735300097
type: Range
begin: 42
end: 52

5030303735300098
type: Active Site Annotation
comment: Charge relay system
range: 5030303735300099

5030303735300099
type: Range
begin: 357
end: 357

503030373530009A
type: Active Site Annotation
comment: Charge relay system
range: 503030373530009B

503030373530009B
type: Range
begin: 406
end: 406

503030373530009C
type: Active Site Annotation
comment: Charge relay system
range: 503030373530009D

503030373530009D
type: Range
begin: 513
end: 513

503030373530009E
type: Site Annotation
comment: Important for binding to LRP1
range: 503030373530009F

503030373530009F
type: Range
begin: 102
end: 102

50303037353000A0
type: Site Annotation
comment: Not glycosylated
range: 50303037353000A1

50303037353000A1
type: Range
begin: 253
end: 253

50303037353000A2
type: Site Annotation
comment: Important for single-chain activity
range: 50303037353000A3

50303037353000A3
type: Range
begin: 464
end: 464

50303037353000A4
type: Site Annotation
comment: Important for single-chain activity
range: 50303037353000A5

50303037353000A5
type: Range
begin: 512
end: 512

CAR_000029
type: Glycosylation Annotation
comment: O-linked (Fuc)
range: 50303037353000A7

50303037353000A7
type: Range
begin: 96
end: 96

50303037353000A8
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 50303037353000A9

50303037353000A9
type: Range
begin: 152
end: 152

CAR_000030
type: Glycosylation Annotation
comment: N-linked (GlcNAc...); partial
range: 50303037353000AA

50303037353000AA
type: Range
begin: 219
end: 219

CAR_000031
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 50303037353000AB

50303037353000AB
type: Range
begin: 483
end: 483

50303037353000AE
type: Range
begin: 41
end: 41

50303037353000AF
type: Range
begin: 71
end: 71

50303037353000B3
type: Range
begin: 69
end: 69

50303037353000B4
type: Range
begin: 78
end: 78

50303037353000B7
type: Range
begin: 86
end: 86

50303037353000B8
type: Range
begin: 97
end: 97

50303037353000BB
type: Range
begin: 91
end: 91

50303037353000BC
type: Range
begin: 108
end: 108

50303037353000BF
type: Range
begin: 110
end: 110

50303037353000C0
type: Range
begin: 119
end: 119

50303037353000C3
type: Range
begin: 127
end: 127

50303037353000C4
type: Range
begin: 208
end: 208

50303037353000C7
type: Range
begin: 148
end: 148

50303037353000C8
type: Range
begin: 190
end: 190

50303037353000CB
type: Range
begin: 179
end: 179

50303037353000CC
type: Range
begin: 203
end: 203

50303037353000CF
type: Range
begin: 215
end: 215

50303037353000D0
type: Range
begin: 296
end: 296

50303037353000D3
type: Range
begin: 236
end: 236

50303037353000D4
type: Range
begin: 278
end: 278

50303037353000D7
type: Range
begin: 267
end: 267

50303037353000D8
type: Range
begin: 291
end: 291

50303037353000D9
type: Disulfide Bond Annotation
comment: Interchain (between A and B chains)
range: 50303037353000DB
range: 50303037353000DC

50303037353000DB
type: Range
begin: 299
end: 299

50303037353000DC
type: Range
begin: 430
end: 430

50303037353000DF
type: Range
begin: 342
end: 342

50303037353000E0
type: Range
begin: 358
end: 358

50303037353000E3
type: Range
begin: 350
end: 350

50303037353000E4
type: Range
begin: 419
end: 419

50303037353000E7
type: Range
begin: 444
end: 444

50303037353000E8
type: Range
begin: 519
end: 519

50303037353000EB
type: Range
begin: 476
end: 476

50303037353000EC
type: Range
begin: 492
end: 492

50303037353000EF
type: Range
begin: 509
end: 509

50303037353000F0
type: Range
begin: 537
end: 537

VSP_028029
type: Alternative Sequence Annotation
comment: In isoform 4.
substitution: MAS
range: 50303037353000F1

50303037353000F1
type: Range
begin: 1
end: 40

VSP_015957
type: Alternative Sequence Annotation
comment: In isoform 3.
substitution: G
range: 50303037353000F2

50303037353000F2
type: Range
begin: 39
end: 85

VSP_028030
type: Alternative Sequence Annotation
comment: In isoform 4.
range: 50303037353000F3

50303037353000F3
type: Range
begin: 79
end: 208

VSP_005411
type: Alternative Sequence Annotation
comment: In isoform 2.
substitution: TGRSVSSPATASMRPCPLSIRSG
range: 50303037353000F4

50303037353000F4
type: Range
begin: 269
end: 291

VSP_005412
type: Alternative Sequence Annotation
comment: In isoform 2.
range: 50303037353000F5

50303037353000F5
type: Range
begin: 292
end: 562

VAR_020181
type: Natural Variant Annotation
substitution: D
range: 50303037353000F7

50303037353000F7
type: Range
begin: 34
end: 34

VAR_038732
type: Natural Variant Annotation
substitution: S
range: 50303037353000FA

50303037353000FA
type: Range
begin: 136
end: 136

VAR_038733
type: Natural Variant Annotation
substitution: T
range: 50303037353000FC

50303037353000FC
type: Range
begin: 146
end: 146

VAR_011783
type: Natural Variant Annotation
substitution: W
range: 50303037353000FE

50303037353000FE
type: Range
begin: 164
end: 164

50303037353000FF
type: Sequence Conflict Annotation
conflicting sequence: 5030303735300050
substitution: T
range: 50303037353000100

50303037353000100
type: Range
begin: 93
end: 93

50303037353000101
type: Sequence Conflict Annotation
conflicting sequence: 5030303735300051
substitution: NA
range: 50303037353000102

50303037353000102
type: Range
begin: 159
end: 160

50303037353000103
type: Sequence Conflict Annotation
conflicting sequence: 5030303735300052
substitution: N
range: 50303037353000104

50303037353000104
type: Range
begin: 247
end: 247

50303037353000105
type: Sequence Conflict Annotation
conflicting sequence: 5030303735300053
substitution: S
range: 50303037353000106

50303037353000106
type: Range
begin: 283
end: 283

50303037353000107
type: Sequence Conflict Annotation
conflicting sequence: 5030303735300054
substitution: EE
range: 50303037353000108

50303037353000108
type: Range
begin: 333
end: 334

50303037353000109
type: Sequence Conflict Annotation
conflicting sequence: 5030303735300054
substitution: C
range: 5030303735300010A

5030303735300010A
type: Range
begin: 389
end: 389

5030303735300010C
type: Range
begin: 44
end: 46

5030303735300010E
type: Range
begin: 55
end: 59

50303037353000110
type: Range
begin: 61
end: 64

50303037353000112
type: Range
begin: 66
end: 70

50303037353000114
type: Range
begin: 72
end: 74

50303037353000116
type: Range
begin: 83
end: 85

50303037353000118
type: Range
begin: 96
end: 104

5030303735300011A
type: Range
begin: 106
end: 109

5030303735300011C
type: Range
begin: 115
end: 118

5030303735300011E
type: Range
begin: 242
end: 244

50303037353000120
type: Range
begin: 248
end: 250

50303037353000122
type: Range
begin: 256
end: 259

50303037353000124
type: Range
begin: 262
end: 264

50303037353000126
type: Range
begin: 277
end: 282

50303037353000128
type: Range
begin: 285
end: 291

5030303735300012A
type: Range
begin: 312
end: 316

5030303735300012C
type: Range
begin: 319
end: 321

5030303735300012E
type: Range
begin: 325
end: 331

50303037353000130
type: Range
begin: 338
end: 346

50303037353000132
type: Range
begin: 348
end: 354

50303037353000134
type: Range
begin: 356
end: 359

50303037353000136
type: Range
begin: 365
end: 367

50303037353000138
type: Range
begin: 368
end: 373

5030303735300013A
type: Range
begin: 375
end: 379

5030303735300013C
type: Range
begin: 385
end: 394

5030303735300013E
type: Range
begin: 400
end: 402

50303037353000140
type: Range
begin: 408
end: 412

50303037353000142
type: Range
begin: 415
end: 417

50303037353000144
type: Range
begin: 443
end: 449

50303037353000146
type: Range
begin: 464
end: 470

50303037353000148
type: Range
begin: 473
end: 475

5030303735300014A
type: Range
begin: 478
end: 483

5030303735300014C
type: Range
begin: 490
end: 494

5030303735300014E
type: Range
begin: 516
end: 521

50303037353000150
type: Range
begin: 524
end: 533

50303037353000152
type: Range
begin: 535
end: 538

50303037353000154
type: Range
begin: 544
end: 548

50303037353000156
type: Range
begin: 549
end: 552

50303037353000158
type: Range
begin: 553
end: 559

50303037353000159
type: Caution Annotation
comment: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
sequence: P00750-2

5030303735300015A
type: Caution Annotation
comment: No experimental confirmation available.
sequence: P00750-3

5030303735300015B
type: Caution Annotation
comment: No experimental confirmation available.
sequence: P00750-4

P00750-1
type: Simple Sequence
modified: 1986-07-21
version: 1
precursor: true
mass: 62917
crc64 checksum: B7EC9B1A5E3FDC4D
name: 1
name: Long
value: MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK DVPGVYTKVT NYLDWIRDNM RP

P00750-2
type: Modified Sequence
name: 2
name: Short
based on: P00750-1
modification: VSP_005411
modification: VSP_005412

P00750-3
type: Modified Sequence
name: 3
based on: P00750-1
modification: VSP_015957

P00750-4
type: Modified Sequence
name: 4
name: Neonatal
based on: P00750-1
modification: VSP_028029
modification: VSP_028030

5030303735300015D
creator: BHF-UCL
evidence: IDA
date: 2010-04-23

50303037353000161
creator: BHF-UCL
evidence: IPI
date: 2010-03-03

50303037353000162
creator: BHF-UCL
evidence: IPI
date: 2010-02-19

50303037353000164
creator: BHF-UCL
evidence: IDA
date: 2010-03-30

50303037353000165
creator: BHF-UCL
evidence: IDA
date: 2010-02-19

50303037353000169
creator: BHF-UCL
evidence: IDA
date: 2010-03-31

EC1
manual: true
source: http://purl.uniprot.org/citations/11384978
date: 2010-07-01

EC2
manual: true
source: http://purl.uniprot.org/citations/8613982
date: 2010-07-01

EC3
manual: true
source: http://purl.uniprot.org/citations/9305622
date: 2010-07-01

EC4
manual: true
source: http://purl.uniprot.org/citations/2513186
date: 2010-07-01

EC5
manual: true
source: http://purl.uniprot.org/citations/1900431
date: 2010-07-01

EC6
manual: true
source: http://purl.uniprot.org/citations/1645336
date: 2010-07-01

EC7
manual: true
source: 5030303735300013
date: 2010-07-01

P56540
type: Protein
reviewed: true
created: 1998-07-15
modified: 2010-08-10
version: 31
mnemonic: CBBQ_CHRVI
citation: http://purl.uniprot.org/citations/2708310
citation: http://purl.uniprot.org/citations/7883189
recommended name: 503536353430005
organism: http://purl.uniprot.org/taxonomy/1049
encoded by: cbbQ
annotation: 503536353430007
annotation: 503536353430008
annotation: PRO_0000219562
annotation: 50353635343000B
annotation: 50353635343000E
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/go/0005524
classified with: http://purl.uniprot.org/go/0016887
sequence: MSDIDRNQFL IDHEPYYRPV SNEVALYEAA YAARMPVMLK GPTGCGKTRF VEYMAWKLGK PLITVACNED MTAS
attribution: 5035363534300011
attribution: 5035363534300013

http://purl.uniprot.org/citations/2708310
type: Journal Citation
title: Expressed genes for plant-type ribulose 1,5-bisphosphate carboxylase/oxygenase in the photosynthetic bacterium Chromatium vinosum, which possesses two complete sets of the genes.
author: Viale A.M.
author: Kobayashi H.
author: Akazawa T.
date: 1989
name: J. Bacteriol.
volume: 171
pages: 2391-2400

503536353430001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

http://purl.uniprot.org/citations/7883189
type: Journal Citation
title: Genes encoding RubisCO in Pseudomonas hydrogenothermophila are followed by a novel cbbQ gene similar to nirQ of the denitrification gene cluster from Pseudomonas species.
author: Yokoyama K.
author: Hayashi N.R.
author: Arai H.
author: Chung S.Y.
author: Igarashi Y.
author: Kodama T.
date: 1995
name: Gene
volume: 153
pages: 75-79

503536353430002
type: Citation Statement
scope: IDENTIFICATION

503536353430003
type: Nucleotide Resource
database: EMBL
located on: M26396

P56540
type: Resource
database: ProteinModelPortal

P56540
type: Resource
database: SMR
comment: 10-72

IPR011704
type: Resource
database: InterPro
comment: ATPase_AAA-5

PF07728
type: Resource
database: Pfam
comment: AAA_5

503536353430004
type: Domain Assignment Statement
hits: 1

503536353430005
type: Structured Name
full name: Protein CbbQ

cbbQ
type: Gene

503536353430007
type: Function Annotation
comment: May affect the post-translational activation and/or assembly of the oligomeric structure of RuBisCO.

503536353430008
type: Similarity Annotation
comment: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

PRO_0000219562
type: Chain Annotation
comment: Protein CbbQ
range: 503536353430009

503536353430009
type: Range
begin: 1
end: 74

50353635343000A
type: Endpoint Statement
limit: false

50353635343000B
type: NP Binding Annotation
comment: ATP
range: 50353635343000D

50353635343000D
type: Range
begin: 41
end: 48

50353635343000F
type: Range
begin: 74
end: 74

MSDIDRNQFL IDHEPYYRPV SNEVALYEAA YAARMPVMLK GPTGCGKTRF VEYMAWKLGK PLITVACNED MTAS
type: Simple Sequence
modified: 1998-07-15
version: 1
fragment: single
mass: 8377
crc64 checksum: B7AB23BF4DEA291C

Q51858
type: Protein
reviewed: true
created: 1998-07-15
modified: 2010-08-10
version: 36
mnemonic: CBBQ_PSEHY
citation: http://purl.uniprot.org/citations/7883189
recommended name: 513531383538005
organism: http://purl.uniprot.org/taxonomy/297
encoded by: cbbQ
annotation: 513531383538007
annotation: 513531383538008
annotation: PRO_0000219563
annotation: 51353138353800A
annotation: 51353138353800D
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/go/0005524
classified with: http://purl.uniprot.org/go/0016887
sequence: Q51858-1
attribution: 5135313835380011
attribution: 5135313835380013

513531383538001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
context: TH-1

TH-1
type: Strain

BAA06439.1
type: Nucleotide Resource
database: EMBL
located on: D30764

Q51858
type: Resource
database: ProteinModelPortal

Q51858
type: Resource
database: SMR
comment: 21-191

IPR013615
type: Resource
database: InterPro
comment: CbbQ_C

513531383538003
type: Domain Assignment Statement
hits: 1

PF08406
type: Resource
database: Pfam
comment: CbbQ_C

513531383538004
type: Domain Assignment Statement
hits: 1

513531383538005
type: Structured Name
full name: Protein CbbQ

cbbQ
type: Gene

513531383538007
type: Function Annotation
comment: May affect the post-translational activation and/or assembly of the oligomeric structure of RuBisCO.

513531383538008
type: Similarity Annotation
comment: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

PRO_0000219563
type: Chain Annotation
comment: Protein CbbQ
range: 513531383538009

513531383538009
type: Range
begin: 1
end: 267

51353138353800A
type: NP Binding Annotation
comment: ATP
range: 51353138353800C

51353138353800C
type: Range
begin: 39
end: 46

51353138353800D
type: NP Binding Annotation
comment: ATP
range: 51353138353800F

51353138353800F
type: Range
begin: 99
end: 106

Q51858-1
type: Simple Sequence
modified: 1996-11-01
version: 1
mass: 29613
crc64 checksum: EA99FE2DB05B0118
value: MDLRNQYLVR SEPYYHAVGD EIERFEAAYA NRIPMMLKGP TGCGKSRFVE YMAWKLGKPL ITVACNEDMT AADLVGRFLL DKEGTRWQDG PLTTAARIGA ICYLDEVVEA RQDTTVVIHP LTDHRRILPL DKKGEVVEAH PDFQIVISYN PGYQSAMKDL KTSTKQRFAA MDFDYPAPEV ESEIVAHESG VDAATAKKLV EVAIRSRHLK GHGLDEGIST RLLVYAGSLI TKGIAPLIAC EMALICPITD DPDLRYALRA AAQTLFA

Q51481
type: Protein
reviewed: true
created: 1998-07-15
modified: 2010-08-10
version: 66
mnemonic: NIRQ_PSEAE
citation: http://purl.uniprot.org/citations/7765251
citation: http://purl.uniprot.org/citations/10984043
recommended name: 513531343831007
organism: http://purl.uniprot.org/taxonomy/287
encoded by: nirQ
annotation: 513531343831009
annotation: 51353134383100A
annotation: 51353134383100D
annotation: 51353134383100E
annotation: PRO_0000219569
annotation: 5135313438310010
annotation: 5135313438310013
annotation: 5135313438310016
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/10
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/181
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/238
classified with: http://purl.uniprot.org/keywords/805
classified with: http://purl.uniprot.org/go/0005737
classified with: http://purl.uniprot.org/go/0005524
classified with: http://purl.uniprot.org/go/0016887
classified with: http://purl.uniprot.org/go/0003677
classified with: http://purl.uniprot.org/go/0045449
classified with: http://purl.uniprot.org/go/0006350
sequence: Q51481-1
attribution: 513531343831001A
attribution: 513531343831001C
attribution: 513531343831001E
attribution: 5135313438310020
attribution: 5135313438310022
attribution: 5135313438310024

http://purl.uniprot.org/citations/7765251
type: Journal Citation
title: Structure and ANR-dependent transcription of the nir genes for denitrification from Pseudomonas aeruginosa.
author: Arai H.
author: Igarashi Y.
author: Kodama T.
date: 1994
name: Biosci. Biotechnol. Biochem.
volume: 58
pages: 1286-1291

513531343831001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
context: PAO1161

PAO1161
type: Strain

http://purl.uniprot.org/citations/10984043
type: Journal Citation
title: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
author: Stover C.K.
author: Pham X.-Q.T.
author: Erwin A.L.
author: Mizoguchi S.D.
author: Warrener P.
author: Hickey M.J.
author: Brinkman F.S.L.
author: Hufnagle W.O.
author: Kowalik D.J.
author: Lagrou M.
author: Garber R.L.
author: Goltry L.
author: Tolentino E.
author: Westbrock-Wadman S.
author: Yuan Y.
author: Brody L.L.
author: Coulter S.N.
author: Folger K.R.
author: Kas A.
author: Larbig K.
author: Lim R.M.
author: Smith K.A.
author: Spencer D.H.
author: Wong G.K.-S.
author: Wu Z.
author: Paulsen I.T.
author: Reizer J.
author: Saier M.H. Jr.
author: Hancock R.E.W.
author: Lory S.
author: Olson M.V.
date: 2000
name: Nature
volume: 406
pages: 959-964

513531343831003
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
context: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228

ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228
type: Strain

BAA07123.1
type: Nucleotide Resource
database: EMBL
located on: D37883

AAG03909.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/AE004091

JC2288
type: Resource
database: PIR

NP 249211.1
type: Resource
database: RefSeq

Q51481
type: Resource
database: ProteinModelPortal

Q51481
type: Resource
database: SMR
comment: 14-183

http://purl.uniprot.org/geneid/882214
type: Resource
database: GeneID

AE004091 GR
type: Resource
database: GenomeReviews
comment: PA0520

pae:PA0520
type: Resource
database: KEGG

fig|208964.1.peg.521
type: Resource
database: NMPDR

PA0520
type: Resource
database: PseudoCAP

HBG295312
type: Resource
database: HOGENOM

HEARILV
type: Resource
database: OMA

CLSK865916
type: Resource
database: ProtClustDB

PAER208964:PA0520-MONOMER
type: Resource
database: BioCyc

513531343831005
type: Domain Assignment Statement
hits: 1

513531343831006
type: Domain Assignment Statement
hits: 1

513531343831007
type: Structured Name
full name: Denitrification regulatory protein nirQ

nirQ
type: Gene
locus name: PA0520

513531343831009
type: Function Annotation
comment: Activator of nitrite and nitric oxide reductases.

51353134383100D
type: Induction Annotation
comment: Under denitrifying conditions.

51353134383100E
type: Similarity Annotation
comment: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

PRO_0000219569
type: Chain Annotation
comment: Denitrification regulatory protein nirQ
range: 51353134383100F

51353134383100F
type: Range
begin: 1
end: 260

5135313438310010
type: NP Binding Annotation
comment: ATP
range: 5135313438310012

5135313438310012
type: Range
begin: 32
end: 39

5135313438310013
type: NP Binding Annotation
comment: ATP
range: 5135313438310015

5135313438310015
type: Range
begin: 92
end: 99

5135313438310016
type: Nucleotide Binding Annotation
comment: H-T-H motif
range: 5135313438310018

5135313438310018
type: Range
begin: 234
end: 253

Q51481-1
type: Simple Sequence
modified: 1996-11-01
version: 1
mass: 28904
crc64 checksum: 3FD36F19BEBA38B5
value: MRDATPFYEA TGHEIEVFER AWRHGLPVLL KGPTGCGKTR FVQYMARRLE LPLYSVACHD DLGAADLLGR HLIGADGTWW QDGPLTRAVR EGGICYLDEV VEARQDTTVA IHPLADDRRE LYLERTGETL QAPPSFMLVV SYNPGYQNLL KGLKPSTRQR FVALRFDYPA AQQEARILVG ESGCAETLAQ RLVQLGQALR RLEQHDLEEV ASTRLLIFAA RLIGDGMDPR EACRVALAEP LSDDPATVAA LMDIVDLHVA

Q8NE62
type: Protein
reviewed: true
created: 2004-02-16
modified: 2010-10-05
version: 72
mnemonic: CHDH_HUMAN
replaces: Q9NY17
citation: http://purl.uniprot.org/citations/16641997
citation: http://purl.uniprot.org/citations/15489334
citation: 51384e453632004
conflicting sequence: 51384e45363200D
recommended name: 51384e45363200E
enzyme: http://purl.uniprot.org/enzyme/1.1.99.1
organism: http://purl.uniprot.org/taxonomy/9606
isolated from: http://purl.uniprot.org/tissues/1030
isolated from: http://purl.uniprot.org/tissues/510
encoded by: CHDH
annotation: 51384e4536320012
annotation: 51384e4536320013
annotation: 51384e4536320014
annotation: 51384e4536320015
annotation: 51384e4536320018
annotation: 51384e4536320019
annotation: PRO_0000012329
annotation: 51384e453632001D
annotation: 51384e4536320020
annotation: 51384e4536320023
annotation: VAR_020421
annotation: VAR_055097
annotation: VAR_049357
annotation: 51384e453632002B
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/7
classified with: http://purl.uniprot.org/keywords/181
classified with: http://purl.uniprot.org/keywords/274
classified with: http://purl.uniprot.org/keywords/285
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/560
classified with: http://purl.uniprot.org/keywords/621
classified with: http://purl.uniprot.org/keywords/809
classified with: http://purl.uniprot.org/go/0008812
classified with: http://purl.uniprot.org/go/0050660
classified with: http://purl.uniprot.org/go/0006066
classified with: http://purl.uniprot.org/go/0055114
sequence: Q8NE62-1
attribution: 51384e453632002E
attribution: 51384e4536320030
attribution: 51384e4536320032
attribution: 51384e4536320034
attribution: EC1

http://purl.uniprot.org/citations/16641997
type: Journal Citation
title: The DNA sequence, annotation and analysis of human chromosome 3.
author: Muzny D.M.
author: Scherer S.E.
author: Kaul R.
author: Wang J.
author: Yu J.
author: Sudbrak R.
author: Buhay C.J.
author: Chen R.
author: Cree A.
author: Ding Y.
author: Dugan-Rocha S.
author: Gill R.
author: Gunaratne P.
author: Harris R.A.
author: Hawes A.C.
author: Hernandez J.
author: Hodgson A.V.
author: Hume J.
author: Jackson A.
author: Khan Z.M.
author: Kovar-Smith C.
author: Lewis L.R.
author: Lozado R.J.
author: Metzker M.L.
author: Milosavljevic A.
author: Miner G.R.
author: Morgan M.B.
author: Nazareth L.V.
author: Scott G.
author: Sodergren E.
author: Song X.-Z.
author: Steffen D.
author: Wei S.
author: Wheeler D.A.
author: Wright M.W.
author: Worley K.C.
author: Yuan Y.
author: Zhang Z.
author: Adams C.Q.
author: Ansari-Lari M.A.
author: Ayele M.
author: Brown M.J.
author: Chen G.
author: Chen Z.
author: Clendenning J.
author: Clerc-Blankenburg K.P.
author: Chen R.'
author: Chen Z.'
author: Davis C.
author: Delgado O.
author: Dinh H.H.
author: Dong W.
author: Draper H.
author: Ernst S.
author: Fu G.
author: Gonzalez-Garay M.L.
author: Garcia D.K.
author: Gillett W.
author: Gu J.
author: Hao B.
author: Haugen E.
author: Havlak P.
author: He X.
author: Hennig S.
author: Hu S.
author: Huang W.
author: Jackson L.R.
author: Jacob L.S.
author: Kelly S.H.
author: Kube M.
author: Levy R.
author: Li Z.
author: Liu B.
author: Liu J.
author: Liu W.
author: Lu J.
author: Maheshwari M.
author: Nguyen B.-V.

51384e453632001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

51384e453632002
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
scope: VARIANT ARG-78
context: Testis

Testis
type: Tissue

51384e453632004
type: Submission Citation
title: Analysis of a putative tumor suppressor gene region of 100 kb at chromosome 3p21.1 in conventional renal cell carcinoma.
author: Bugert P.
author: Hanke S.
author: Chudek J.
author: Kovacs G.
date: 2000-02
submitted to: EMBL/GenBank/DDBJ

51384e453632005
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] OF 113-594
context: Kidney

Kidney
type: Tissue

51384e453632007
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/AC012467

AAH34502.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC034502

CAB75961.1
type: Nucleotide Resource
database: EMBL
located on: AJ272267
citation: 51384e453632004

IPI00168603
type: Resource
database: IPI

NP 060867.2
type: Resource
database: RefSeq

Hs.126688
type: Resource
database: UniGene

Q8NE62
type: Resource
database: ProteinModelPortal

Q8NE62
type: Resource
database: STRING

Q8NE62
type: Resource
database: PhosphoSite

ENST00000315251
type: Transcript Resource
database: Ensembl
translated to: ENSP00000319851
transcribed from: ENSG00000016391

http://purl.uniprot.org/geneid/55349
type: Resource
database: GeneID

hsa:55349
type: Resource
database: KEGG

uc003dgz.1
type: Resource
database: UCSC
comment: human

http://purl.uniprot.org/ctd/55349
type: Resource
database: CTD

GC03M053826
type: Resource
database: GeneCards

http://purl.uniprot.org/hgnc/24288
type: Resource
database: HGNC
comment: CHDH

PA134873121
type: Resource
database: PharmGKB

prNOG07180
type: Resource
database: eggNOG

HBG734713
type: Resource
database: HOGENOM

HBG023639
type: Resource
database: HOVERGEN

Q8NE62
type: Resource
database: InParanoid

SRDEYSY
type: Resource
database: OMA

EOG9962C6
type: Resource
database: OrthoDB

Q8NE62
type: Resource
database: PhylomeDB

http://purl.uniprot.org/brenda/1.1.99.1
type: Resource
database: BRENDA
comment: 247

DB00122
type: Resource
database: DrugBank
comment: Choline

http://purl.uniprot.org/nextbio/59691
type: Resource
database: NextBio

Q8NE62
type: Resource
database: ArrayExpress

Q8NE62
type: Resource
database: Bgee

HS CHDH
type: Resource
database: CleanEx

Q8NE62
type: Resource
database: Genevestigator

ENSG00000016391
type: Resource
database: GermOnline
comment: Homo sapiens

IPR012132
type: Resource
database: InterPro
comment: GMC_OxRdtase

IPR000172
type: Resource
database: InterPro
comment: GMC_OxRdtase_N

IPR007867
type: Resource
database: InterPro
comment: GMC_OxRtase_C

PF05199
type: Resource
database: Pfam
comment: GMC_oxred_C

51384e453632008
type: Domain Assignment Statement
hits: 1

PF00732
type: Resource
database: Pfam
comment: GMC_oxred_N

51384e453632009
type: Domain Assignment Statement
hits: 1

PIRSF000137
type: Resource
database: PIRSF
comment: Alcohol_oxidase

51384e45363200A
type: Domain Assignment Statement
hits: 1

PS00623
type: Resource
database: PROSITE
comment: GMC_OXRED_1

51384e45363200B
type: Domain Assignment Statement
hits: 1

PS00624
type: Resource
database: PROSITE
comment: GMC_OXRED_2

51384e45363200C
type: Domain Assignment Statement
hits: 1

51384e45363200E
type: Structured Name
full name: Choline dehydrogenase, mitochondrial
short name: CDH
short name: CHD
ec name: 1.1.99.1

CHDH
type: Gene

51384e4536320012
type: Catalytic Activity Annotation
comment: Choline + acceptor = betaine aldehyde + reduced acceptor.

51384e4536320013
type: Cofactor Annotation
comment: FAD (By similarity).

51384e4536320014
type: Pathway Annotation
comment: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.

51384e4536320018
type: Similarity Annotation
comment: Belongs to the GMC oxidoreductase family.

51384e4536320019
type: Transit Peptide Annotation
comment: Mitochondrion
range: 51384e453632001B

51384e453632001B
type: Range
begin: 1

PRO_0000012329
type: Chain Annotation
comment: Choline dehydrogenase, mitochondrial
range: 51384e453632001C

51384e453632001C
type: Range
end: 594

51384e453632001D
type: NP Binding Annotation
comment: FAD
range: 51384e453632001F

51384e453632001F
type: Range
begin: 42
end: 71

51384e4536320022
type: Range
begin: 511
end: 511

51384e4536320023
type: Modified Residue Annotation
comment: N6-acetyllysine
range: 51384e4536320025

51384e4536320025
type: Range
begin: 496
end: 496

VAR_020421
type: Natural Variant Annotation
substitution: A
range: 51384e4536320026

51384e4536320026
type: Range
begin: 40
end: 40

VAR_055097
type: Natural Variant Annotation
substitution: R
range: 51384e4536320028

51384e4536320028
type: Range
begin: 78
end: 78

VAR_049357
type: Natural Variant Annotation
substitution: S
range: 51384e453632002A

51384e453632002A
type: Range
begin: 441
end: 441

51384e453632002B
type: Sequence Conflict Annotation
conflicting sequence: 51384e45363200D
substitution: A
range: 51384e453632002C

51384e453632002C
type: Range
begin: 113
end: 113

Q8NE62-1
type: Simple Sequence
modified: 2009-05-05
version: 2
precursor: true
mass: 65358
crc64 checksum: E9764CD0F325A501
value: MWCLLRGLGR PGALARGALG QQQSLGARAL ASAGSESRDE YSYVVVGAGS AGCVLAGRLT EDPAERVLLL EAGPKDVLAG SKRLSWKIHM PAALVANLCD DRYNWCYHTE VQRGLDGRVL YWPRGRVWGG SSSLNAMVYV RGHAEDYERW QRQGARGWDY AHCLPYFRKA QGHELGASRY RGADGPLRVS RGKTNHPLHC AFLEATQQAG YPLTEDMNGF QQEGFGWMDM TIHEGKRWSA ACAYLHPALS RTNLKAEAET LVSRVLFEGT RAVGVEYVKN GQSHRAYASK EVILSGGAIN SPQLLMLSGI GNADDLKKLG IPVVCHLPGV GQNLQDHLEI YIQQACTRPI TLHSAQKPLR KVCIGLEWLW KFTGEGATAH LETGGFIRSQ PGVPHPDIQF HFLPSQVIDH GRVPTQQEAY QVHVGPMRGT SVGWLKLRSA NPQDHPVIQP NYLSTETDIE DFRLCVKLTR EIFAQEALAP FRGKELQPGS HIQSDKEIDA FVRAKADSAY HPSCTCKMGQ PSDPTAVVDP QTRVLGVENL RVVDASIMPS MVSGNLNAPT IMIAEKAADI IKGQPALWDK DVPVYKPRTL ATQR

EC1
manual: true
source: http://purl.uniprot.org/citations/15489334
date: 2010-07-01

P00981
type: Protein
reviewed: true
created: 1986-07-21
modified: 2010-08-10
version: 84
mnemonic: IVBKI_DENPO
mnemonic: IVBK_DENPO
replaces: Q91351
citation: http://purl.uniprot.org/citations/8504088
citation: http://purl.uniprot.org/citations/857902
citation: http://purl.uniprot.org/citations/8254670
recommended name: 50303039383100C
alternative name: 50303039383100D
organism: http://purl.uniprot.org/taxonomy/8620
isolated from: http://purl.uniprot.org/tissues/1109
annotation: 50303039383100F
annotation: 5030303938310010
annotation: 5030303938310012
annotation: 5030303938310013
annotation: 5030303938310014
annotation: 5030303938310015
annotation: PRO_0000016869
annotation: PRO_0000016870
annotation: 503030393831001A
annotation: 503030393831001C
annotation: 503030393831001E
annotation: 5030303938310022
annotation: 5030303938310026
annotation: 503030393831002A
annotation: 503030393831002C
annotation: 503030393831002E
annotation: 5030303938310030
annotation: 5030303938310032
annotation: 5030303938310034
annotation: 5030303938310036
annotation: 5030303938310038
annotation: 503030393831003A
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/528
classified with: http://purl.uniprot.org/keywords/632
classified with: http://purl.uniprot.org/keywords/964
classified with: http://purl.uniprot.org/keywords/722
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/go/0005576
classified with: http://purl.uniprot.org/go/0019870
classified with: http://purl.uniprot.org/go/0004867
classified with: http://purl.uniprot.org/go/0009405
sequence: SGHLLLLLGL LTLWAELTPV SGAAKYCKLP LRIGPCKRKI PSFYYKWKAK QCLPFDYSGC GGNANRFKTI EECRRTCVG
attribution: 503030393831003D
attribution: 503030393831003F
attribution: 5030303938310041
attribution: 5030303938310043

http://purl.uniprot.org/citations/8504088
type: Journal Citation
title: Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker.
author: Smith L.A.
author: Lafaye P.J.
author: LaPenotiere H.F.
author: Spain T.
author: Dolly J.O.
date: 1993
name: Biochemistry
volume: 32
pages: 5692-5697

503030393831001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: PROTEIN SEQUENCE OF 23-39

http://purl.uniprot.org/citations/857902
type: Journal Citation
title: Snake venom toxins. The amino acid sequence of toxin Vi2, a homologue of pancreatic trypsin inhibitor, from Dendroaspis polylepis polylepis (black mamba) venom.
author: Strydom D.J.
date: 1977
name: Biochim. Biophys. Acta
volume: 491
pages: 361-369

503030393831002
type: Citation Statement
scope: PROTEIN SEQUENCE OF 23-79
context: Venom

Venom
type: Tissue

http://purl.uniprot.org/citations/8254670
type: Journal Citation
title: Nuclear magnetic resonance solution structure of dendrotoxin K from the venom of Dendroaspis polylepis polylepis.
author: Berndt K.D.
author: Guentert P.
author: Wuethrich K.
date: 1993
name: J. Mol. Biol.
volume: 234
pages: 735-750

503030393831004
type: Citation Statement
scope: STRUCTURE BY NMR OF 23-79

AAB26998.1
type: Nucleotide Resource
database: EMBL
located on: S61886

TIEPVK
type: Resource
database: PIR
comment: A49291

1DTK
type: Structure Resource
database: PDB
method: NMR Spectroscopy

503030393831005
type: Structure Mapping Statement
chain: A=23-79

1DTK
type: Resource
database: PDBsum

P00981
type: Resource
database: ProteinModelPortal

IPR002223
type: Resource
database: InterPro
comment: Prot_inh_Kunz-m

IPR020901
type: Resource
database: InterPro
comment: Prtase_inh_Kunz-CS

G3DSA:4.10.410.10
type: Resource
database: Gene3D
comment: Prot_inh_Kunz-m

503030393831006
type: Domain Assignment Statement
hits: 1

PF00014
type: Resource
database: Pfam
comment: Kunitz_BPTI

503030393831007
type: Domain Assignment Statement
hits: 1

PR00759
type: Resource
database: PRINTS
comment: BASICPTASE

SM00131
type: Resource
database: SMART
comment: KU

503030393831008
type: Domain Assignment Statement
hits: 1

SSF57362
type: Resource
database: SUPFAM
comment: Prot_inh_Kunz-m

503030393831009
type: Domain Assignment Statement
hits: 1

PS00280
type: Resource
database: PROSITE
comment: BPTI_KUNITZ_1

50303039383100A
type: Domain Assignment Statement
hits: 1

PS50279
type: Resource
database: PROSITE
comment: BPTI_KUNITZ_2

50303039383100B
type: Domain Assignment Statement
hits: 1

50303039383100C
type: Structured Name
full name: Dendrotoxin-K
short name: DTX-K

50303039383100D
type: Structured Name
full name: Venom basic protease inhibitor K

50303039383100F
type: Function Annotation
comment: This protein is much less toxic to mice than is whole venom. It inhibits trypsin slightly, but chymotrypsin not at all. It is a highly selective blocker of voltage-gated potassium channels.

5030303938310012
type: Tissue Specificity Annotation
comment: Expressed by the venom gland.

5030303938310013
type: Toxic Dose Annotation
comment: LD(50) is 30 mg/kg by intravenous injection.

5030303938310014
type: Similarity Annotation
comment: Contains 1 BPTI/Kunitz inhibitor domain.

5030303938310016
type: Range
begin: 1

5030303938310017
type: Endpoint Statement
limit: false

5030303938310018
type: Range
end: 22

PRO_0000016870
type: Chain Annotation
comment: Dendrotoxin-K
range: 5030303938310019

5030303938310019
type: Range
begin: 23
end: 79

503030393831001A
type: Domain Extent Annotation
comment: BPTI/Kunitz inhibitor
range: 503030393831001B

503030393831001B
type: Range
begin: 27
end: 77

503030393831001C
type: Site Annotation
comment: Reactive bond
range: 503030393831001D

503030393831001D
type: Range
begin: 37
end: 38

5030303938310020
type: Range
begin: 27
end: 27

5030303938310021
type: Range
begin: 77
end: 77

5030303938310024
type: Range
begin: 36
end: 36

5030303938310025
type: Range
begin: 60
end: 60

5030303938310028
type: Range
begin: 52
end: 52

5030303938310029
type: Range
begin: 73
end: 73

503030393831002B
type: Range
begin: 1
end: 1

503030393831002D
type: Range
begin: 25
end: 28

503030393831002F
type: Range
begin: 35
end: 37

5030303938310031
type: Range
begin: 40
end: 45

5030303938310033
type: Range
begin: 47
end: 49

5030303938310035
type: Range
begin: 50
end: 57

5030303938310037
type: Range
begin: 59
end: 61

5030303938310039
type: Range
begin: 67
end: 69

503030393831003B
type: Range
begin: 70
end: 77

SGHLLLLLGL LTLWAELTPV SGAAKYCKLP LRIGPCKRKI PSFYYKWKAK QCLPFDYSGC GGNANRFKTI EECRRTCVG
type: Simple Sequence
modified: 2004-03-15
version: 2
precursor: true
fragment: single
mass: 8852
crc64 checksum: DCDFB9AFA07D7D46

P28799
type: Protein
reviewed: true
created: 1992-12-01
modified: 2010-11-02
version: 120
mnemonic: GRN_HUMAN
replaces: P23781
replaces: P23782
replaces: P23783
replaces: P23784
replaces: Q53Y88
replaces: Q540U8
replaces: Q9BWE7
replaces: Q9UCH0
citation: http://purl.uniprot.org/citations/1417868
citation: http://purl.uniprot.org/citations/1618805
citation: http://purl.uniprot.org/citations/1542665
citation: 503238373939006
citation: 503238373939008
citation: 50323837393900B
citation: 50323837393900D
citation: http://purl.uniprot.org/citations/15489334
citation: http://purl.uniprot.org/citations/2268320
citation: http://purl.uniprot.org/citations/8471426
citation: http://purl.uniprot.org/citations/19159218
citation: http://purl.uniprot.org/citations/10715107
citation: http://purl.uniprot.org/citations/16862116
citation: http://purl.uniprot.org/citations/16983685
citation: http://purl.uniprot.org/citations/18183624
conflicting sequence: 5032383739390025
conflicting sequence: 5032383739390026
conflicting sequence: 5032383739390027
recommended name: 5032383739390028
alternative name: 5032383739390029
component: 503238373939002A
component: 503238373939002C
component: 503238373939002E
component: 5032383739390031
component: 5032383739390034
component: 5032383739390037
component: 503238373939003A
component: 503238373939003D
component: 5032383739390040
organism: http://purl.uniprot.org/taxonomy/9606
isolated from: http://purl.uniprot.org/tissues/510
isolated from: http://purl.uniprot.org/tissues/87
isolated from: http://purl.uniprot.org/tissues/95
isolated from: http://purl.uniprot.org/tissues/134
isolated from: http://purl.uniprot.org/tissues/568
isolated from: http://purl.uniprot.org/tissues/549
isolated from: http://purl.uniprot.org/tissues/564
encoded by: GRN
annotation: 503238373939004B
annotation: 503238373939004C
annotation: 503238373939004D
annotation: 503238373939004F
annotation: 5032383739390050
annotation: 5032383739390051
annotation: 5032383739390052
annotation: 5032383739390057
annotation: 5032383739390058
annotation: PRO_0000012693
annotation: PRO_0000012694
annotation: PRO_0000012695
annotation: PRO_0000012696
annotation: PRO_0000012697
annotation: PRO_0000012698
annotation: PRO_0000012699
annotation: PRO_0000012700
annotation: PRO_0000012701
annotation: 503238373939006D
annotation: 5032383739390070
annotation: 5032383739390073
annotation: 5032383739390077
annotation: 5032383739390079
annotation: 503238373939007C
annotation: 503238373939007F
annotation: VSP_001837
annotation: VAR_044451
annotation: VAR_014830

http://purl.uniprot.org/citations/1417868
type: Journal Citation
title: Structure and chromosomal location of the human granulin gene.
author: Bhandari V.
author: Bateman A.
date: 1992
name: Biochem. Biophys. Res. Commun.
volume: 188
pages: 57-63

503238373939001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: SEQUENCE REVISION

http://purl.uniprot.org/citations/1618805
type: Journal Citation
title: The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
author: Plowman G.D.
author: Green J.M.
author: Neubauer M.G.
author: Buckley S.D.
author: McDonald V.L.
author: Todaro G.J.
author: Shoyab M.
date: 1992
name: J. Biol. Chem.
volume: 267
pages: 13073-13078

503238373939002
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
context: Kidney

Kidney
type: Tissue

http://purl.uniprot.org/citations/1542665
type: Journal Citation
title: Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
author: Bhandari V.
author: Palfree R.G.E.
author: Bateman A.
date: 1992
name: Proc. Natl. Acad. Sci. U.S.A.
volume: 89
pages: 1715-1719

503238373939004
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: PARTIAL PROTEIN SEQUENCE
context: Bone marrow

Bone marrow
type: Tissue

503238373939006
type: Submission Citation
title: PCDGF sequence from lambda phage human Jurkat T cell cDNA library (Clontech).
author: Lu R.
author: Tian C.
author: Serrero G.
date: 2002-06
submitted to: EMBL/GenBank/DDBJ

503238373939007
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

503238373939008
type: Submission Citation
author: Yu W.
author: Gibbs R.A.
date: 1998-03
submitted to: EMBL/GenBank/DDBJ

503238373939009
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
context: Brain

Brain
type: Tissue

50323837393900B
type: Submission Citation
title: Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
author: Kalnine N.
author: Chen X.
author: Rolfs A.
author: Halleck A.
author: Hines L.
author: Eisenstein S.
author: Koundinya M.
author: Raphael J.
author: Moreira D.
author: Kelley T.
author: LaBaer J.
author: Lin Y.
author: Phelan M.
author: Farmer A.
date: 2003-05
submitted to: EMBL/GenBank/DDBJ

50323837393900C
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)

50323837393900D
type: Submission Citation
author: Mural R.J.
author: Istrail S.
author: Sutton G.G.
author: Florea L.
author: Halpern A.L.
author: Mobarry C.M.
author: Lippert R.
author: Walenz B.
author: Shatkay H.
author: Dew I.
author: Miller J.R.
author: Flanigan M.J.
author: Edwards N.J.
author: Bolanos R.
author: Fasulo D.
author: Halldorsson B.V.
author: Hannenhalli S.
author: Turner R.
author: Yooseph S.
author: Lu F.
author: Nusskern D.R.
author: Shue B.C.
author: Zheng X.H.
author: Zhong F.
author: Delcher A.L.
author: Huson D.H.
author: Kravitz S.A.
author: Mouchard L.
author: Reinert K.
author: Remington K.A.
author: Clark A.G.
author: Waterman M.S.
author: Eichler E.E.
author: Adams M.D.
author: Hunkapiller M.W.
author: Myers E.W.
author: Venter J.C.
date: 2005-09
submitted to: EMBL/GenBank/DDBJ

50323837393900E
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

50323837393900F
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
context: Cervix
context: Lung

Cervix
type: Tissue

Lung
type: Tissue

http://purl.uniprot.org/citations/2268320
type: Journal Citation
title: Granulins, a novel class of peptide from leukocytes.
author: Bateman A.
author: Belcourt D.R.
author: Bennett H.P.
author: Lazure C.
author: Solomon S.
date: 1990
name: Biochem. Biophys. Res. Commun.
volume: 173
pages: 1161-1168

5032383739390012
type: Citation Statement
scope: PROTEIN SEQUENCE OF 206-233; 281-336; 364-396 AND 442-447
context: Leukocyte

Leukocyte
type: Tissue

http://purl.uniprot.org/citations/8471426
type: Journal Citation
title: Characterisation of UGP and its relationship with beta-core fragment.
author: Kardana A.
author: Bagshawe K.D.
author: Coles B.
author: Read D.
author: Taylor M.
date: 1993
name: Br. J. Cancer
volume: 67
pages: 686-692

5032383739390014
type: Citation Statement
scope: PROTEIN SEQUENCE OF 281-295

http://purl.uniprot.org/citations/19159218
type: Journal Citation
title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
author: Chen R.
author: Jiang X.
author: Sun D.
author: Han G.
author: Wang F.
author: Ye M.
author: Wang L.
author: Zou H.
date: 2009
name: J. Proteome Res.
volume: 8
pages: 651-661

5032383739390015
type: Citation Statement
scope: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-265
scope: MASS SPECTROMETRY
context: Liver

Liver
type: Tissue

http://purl.uniprot.org/citations/10715107
type: Journal Citation
title: Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A.
author: Tolkatchev D.
author: Ng A.
author: Vranken W.
author: Ni F.
date: 2000
name: Biochemistry
volume: 39
pages: 2878-2886

5032383739390017
type: Citation Statement
scope: STRUCTURE BY NMR OF 284-311

http://purl.uniprot.org/citations/16862116
type: Journal Citation
title: Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
author: Baker M.
author: Mackenzie I.R.
author: Pickering-Brown S.M.
author: Gass J.
author: Rademakers R.
author: Lindholm C.
author: Snowden J.
author: Adamson J.
author: Sadovnick A.D.
author: Rollinson S.
author: Cannon A.
author: Dwosh E.
author: Neary D.
author: Melquist S.
author: Richardson A.
author: Dickson D.
author: Berger Z.
author: Eriksen J.
author: Robinson T.
author: Zehr C.
author: Dickey C.A.
author: Crook R.
author: McGowan E.
author: Mann D.
author: Boeve B.
author: Feldman H.
author: Hutton M.
date: 2006
name: Nature
volume: 442
pages: 916-919

5032383739390018
type: Citation Statement
scope: INVOLVEMENT IN UP-FTD

http://purl.uniprot.org/citations/16983685
type: Journal Citation
title: HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin.
author: Mukherjee O.
author: Pastor P.
author: Cairns N.J.
author: Chakraverty S.
author: Kauwe J.S.K.
author: Shears S.
author: Behrens M.I.
author: Budde J.
author: Hinrichs A.L.
author: Norton J.
author: Levitch D.
author: Taylor-Reinwald L.
author: Gitcho M.
author: Tu P.-H.
author: Tenenholz Grinberg L.
author: Liscic R.M.
author: Armendariz J.
author: Morris J.C.
author: Goate A.M.
date: 2006
name: Ann. Neurol.
volume: 60
pages: 314-322

5032383739390019
type: Citation Statement
scope: VARIANT UP-FTD ASP-9

http://purl.uniprot.org/citations/18183624
type: Journal Citation
title: Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.
author: Mukherjee O.
author: Wang J.
author: Gitcho M.
author: Chakraverty S.
author: Taylor-Reinwald L.
author: Shears S.
author: Kauwe J.S.K.
author: Norton J.
author: Levitch D.
author: Bigio E.H.
author: Hatanpaa K.J.
author: White C.L.
author: Morris J.C.
author: Cairns N.J.
author: Goate A.
date: 2008
name: Hum. Mutat.
volume: 29
pages: 512-521

503238373939001A
type: Citation Statement
scope: CHARACTERIZATION OF VARIANT UP-FTD ASP-9

GRNID40757ch17q21.html
type: Resource
comment: Atlas of Genetics and Cytogenetics in Oncology and Haematology

GRN
type: Resource
comment: GeneReviews

CAA44196.1
type: Nucleotide Resource
database: EMBL
located on: X62320

AAC09359.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/AF055008

AAA58617.1
type: Nucleotide Resource
database: EMBL
located on: M75161
citation: http://purl.uniprot.org/citations/1542665

503238373939001B
type: Nucleotide Mapping Statement
comment: Sequence problems.

AAM94026.1
type: Nucleotide Resource
database: EMBL
located on: AY124489

AAP35490.1
type: Nucleotide Resource
database: EMBL
located on: BT006844

EAW51599.1
type: Nucleotide Resource
database: EMBL
located on: CH471178

AAH00324.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC000324

AAH10577.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/BC010577

IPI00182138
type: Resource
database: IPI

IPI00296713
type: Resource
database: IPI

GYHU
type: Resource
database: PIR
comment: JC1284

NP 002078.1
type: Resource
database: RefSeq

Hs.514220
type: Resource
database: UniGene

1G26
type: Structure Resource
database: PDB
method: NMR Spectroscopy

503238373939001C
type: Structure Mapping Statement
chain: A=284-311

2JYE
type: Structure Resource
database: PDB
method: NMR Spectroscopy

503238373939001D
type: Structure Mapping Statement
chain: A=281-337

2JYT
type: Structure Resource
database: PDB
method: NMR Spectroscopy

503238373939001E
type: Structure Mapping Statement
chain: A=364-417

2JYU
type: Structure Resource
database: PDB
method: NMR Spectroscopy

503238373939001F
type: Structure Mapping Statement
chain: A=364-417

2JYV
type: Structure Resource
database: PDB
method: NMR Spectroscopy

5032383739390020
type: Structure Mapping Statement
chain: A=123-179

1G26
type: Resource
database: PDBsum

2JYE
type: Resource
database: PDBsum

2JYT
type: Resource
database: PDBsum

2JYU
type: Resource
database: PDBsum

2JYV
type: Resource
database: PDBsum

P28799
type: Resource
database: ProteinModelPortal

P28799
type: Resource
database: SMR
comment: 206-236

P28799
type: Resource
database: IntAct
comment: 23

MINT-271687
type: Resource
database: MINT

P28799
type: Resource
database: STRING

P28799
type: Resource
database: PRIDE

ENST00000053867
type: Transcript Resource
database: Ensembl
translated to: ENSP00000053867
transcribed from: ENSG00000030582

http://purl.uniprot.org/geneid/2896
type: Resource
database: GeneID

hsa:2896
type: Resource
database: KEGG

uc002igp.1
type: Resource
database: UCSC
comment: human

http://purl.uniprot.org/ctd/2896
type: Resource
database: CTD

GC17P042433
type: Resource
database: GeneCards

HIX0013882
type: Resource
database: H-InvDB

http://purl.uniprot.org/hgnc/4601
type: Resource
database: HGNC
comment: GRN

http://purl.uniprot.org/hpa/CAB019394
type: Resource
database: HPA

HPA008763
type: Resource
database: HPA

HPA028747
type: Resource
database: HPA

http://purl.uniprot.org/mim/138945
type: Resource
database: MIM
comment: gene

http://purl.uniprot.org/mim/607485
type: Resource
database: MIM
comment: phenotype

http://purl.uniprot.org/orphanet/98929
type: Resource
database: Orphanet
comment: Frontotemporal dementia with motor neuron-disease type inclusions

PA24626
type: Resource
database: PharmGKB

prNOG11069
type: Resource
database: eggNOG

HBG000845
type: Resource
database: HOVERGEN

P28799
type: Resource
database: InParanoid

CCEDRVH
type: Resource
database: OMA

EOG9JQ6HG
type: Resource
database: OrthoDB

P28799
type: Resource
database: PhylomeDB

http://purl.uniprot.org/nextbio/11459
type: Resource
database: NextBio

P28799
type: Resource
database: PMAP-CutDB

P28799
type: Resource
database: ArrayExpress

P28799
type: Resource
database: Bgee

HS GRN
type: Resource
database: CleanEx

P28799
type: Resource
database: Genevestigator

ENSG00000030582
type: Resource
database: GermOnline
comment: Homo sapiens

IPR006150
type: Resource
database: InterPro
comment: Cys_repeat_1

IPR000118
type: Resource
database: InterPro
comment: Granulin

PF00396
type: Resource
database: Pfam
comment: Granulin

5032383739390021
type: Domain Assignment Statement
hits: 7

SM00277
type: Resource
database: SMART
comment: GRAN

5032383739390022
type: Domain Assignment Statement
hits: 7

SM00289
type: Resource
database: SMART
comment: WR1

5032383739390023
type: Domain Assignment Statement
hits: 5

PS00799
type: Resource
database: PROSITE
comment: GRANULINS

5032383739390024
type: Domain Assignment Statement
hits: 7

5032383739390025
type: External Sequence
comment: AA sequence
citation: http://purl.uniprot.org/citations/2268320

5032383739390026
type: External Sequence
comment: AA sequence
citation: http://purl.uniprot.org/citations/8471426

5032383739390028
type: Structured Name
full name: Granulins

5032383739390029
type: Structured Name
full name: Proepithelin
short name: PEPI

503238373939002B
type: Structured Name
full name: Acrogranin

503238373939002D
type: Structured Name
full name: Paragranulin

503238373939002F
type: Structured Name
full name: Granulin-1

5032383739390030
type: Structured Name
full name: Granulin G

5032383739390032
type: Structured Name
full name: Granulin-2

5032383739390033
type: Structured Name
full name: Granulin F

5032383739390035
type: Structured Name
full name: Granulin-3

5032383739390036
type: Structured Name
full name: Granulin B

5032383739390038
type: Structured Name
full name: Granulin-4

5032383739390039
type: Structured Name
full name: Granulin A

503238373939003B
type: Structured Name
full name: Granulin-5

503238373939003C
type: Structured Name
full name: Granulin C

503238373939003E
type: Structured Name
full name: Granulin-6

503238373939003F
type: Structured Name
full name: Granulin D

5032383739390041
type: Structured Name
full name: Granulin-7

5032383739390042
type: Structured Name
full name: Granulin E

GRN
type: Gene

503238373939004B
type: Function Annotation
comment: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.

503238373939004C
type: Function Annotation
comment: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

5032383739390050
type: Tissue Specificity Annotation
comment: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

5032383739390051
type: PTM Annotation
comment: Granulins are disulfide bridged.

5032383739390052
type: Disease Annotation
comment: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.

5032383739390057
type: Similarity Annotation
comment: Belongs to the granulin family.

503238373939005A
type: Range
begin: 1
end: 17

PRO_0000012693
type: Chain Annotation
comment: Acrogranin
range: 503238373939005B

503238373939005B
type: Range
begin: 18
end: 593

PRO_0000012694
type: Peptide Annotation
comment: Paragranulin
range: 503238373939005C

503238373939005C
type: Range
begin: 18
end: 47

503238373939005D
type: Endpoint Statement
certain: false

PRO_0000012695
type: Peptide Annotation
comment: Granulin-1
range: 503238373939005E

503238373939005E
type: Range
begin: 58
end: 113

503238373939005F
type: Endpoint Statement
certain: false

5032383739390060
type: Endpoint Statement
certain: false

PRO_0000012696
type: Peptide Annotation
comment: Granulin-2
range: 5032383739390061

5032383739390061
type: Range
begin: 123
end: 179

5032383739390062
type: Endpoint Statement
certain: false

5032383739390063
type: Endpoint Statement
certain: false

PRO_0000012697
type: Peptide Annotation
comment: Granulin-3
range: 5032383739390064

5032383739390064
type: Range
begin: 206
end: 261

PRO_0000012698
type: Peptide Annotation
comment: Granulin-4
range: 5032383739390065

5032383739390065
type: Range
begin: 281
end: 336

PRO_0000012699
type: Peptide Annotation
comment: Granulin-5
range: 5032383739390066

5032383739390066
type: Range
begin: 364
end: 417

5032383739390067
type: Endpoint Statement
certain: false

PRO_0000012700
type: Peptide Annotation
comment: Granulin-6
range: 5032383739390068

5032383739390068
type: Range
begin: 442
end: 496

5032383739390069
type: Endpoint Statement
certain: false

PRO_0000012701
type: Peptide Annotation
comment: Granulin-7
range: 503238373939006A

503238373939006A
type: Range
begin: 518
end: 573

503238373939006B
type: Endpoint Statement
certain: false

503238373939006C
type: Endpoint Statement
certain: false

503238373939006D
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 503238373939006F

503238373939006F
type: Range
begin: 118
end: 118

5032383739390070
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 5032383739390072

5032383739390072
type: Range
begin: 236
end: 236

5032383739390073
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 5032383739390075

5032383739390075
type: Range
begin: 265
end: 265

5032383739390077
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 5032383739390078

5032383739390078
type: Range
begin: 368
end: 368

5032383739390079
type: Glycosylation Annotation
comment: N-linked (GlcNAc...)
range: 503238373939007B

503238373939007B
type: Range
begin: 530
end: 530

503238373939007D
type: Range
begin: 284
end: 284

503238373939007E
type: Range
begin: 296
end: 296

5032383739390080
type: Range
begin: 290
end: 290

5032383739390081
type: Range
begin: 306
end: 306

VSP_001837
type: Alternative Sequence Annotation
comment: In isoform 2.
range: 5032383739390082

5032383739390082
type: Range
begin: 377
end: 531

VAR_044451
type: Natural Variant Annotation
comment: In UP-FTD; no significant difference in the total mRNA between cases and controls; although the mutant protein is expressed it is not secreted and appears to be trapped within an intracellular compartment.
substitution: D
range: 5032383739390084

5032383739390084
type: Range
begin: 9
end: 9

VAR_014830
type: Natural Variant Annotation
substitution: A
range: 5032383739390085

5032383739390085
type: Range
begin: 515
end: 515

5032383739390086
type: Sequence Conflict Annotation
conflicting sequence: 5032383739390025
substitution: H
range: 5032383739390087

5032383739390087
type: Range
begin: 219
end: 219

5032383739390088
type: Sequence Conflict Annotation
conflicting sequence: 5032383739390026
substitution: S
range: 5032383739390089

5032383739390089
type: Range
begin: 290
end: 290

503238373939008A
type: Sequence Conflict Annotation
conflicting sequence: 5032383739390025
substitution: H
range: 503238373939008B

503238373939008B
type: Range
begin: 386
end: 386

503238373939008C
type: Sequence Conflict Annotation
conflicting sequence: 5032383739390027
substitution: G
range: 503238373939008D

503238373939008D
type: Range
begin: 454
end: 454

503238373939008F
type: Range
begin: 137
end: 141

5032383739390091
type: Range
begin: 143
end: 145

5032383739390093
type: Range
begin: 147
end: 151

5032383739390095
type: Range
begin: 282
end: 285

5032383739390097
type: Range
begin: 288
end: 290

5032383739390099
type: Range
begin: 294
end: 298

503238373939009B
type: Range
begin: 304
end: 308

503238373939009D
type: Range
begin: 315
end: 319

503238373939009F
type: Range
begin: 330
end: 333

50323837393900A1
type: Range
begin: 377
end: 380

50323837393900A3
type: Range
begin: 382
end: 384

50323837393900A5
type: Range
begin: 386
end: 389

50323837393900A7
type: Range
begin: 409
end: 411

50323837393900A9
type: Range
begin: 412
end: 414

50323837393900AB
type: Range
begin: 415
end: 417

P28799-1
type: Simple Sequence
modified: 2005-10-11
version: 2
precursor: true
mass: 63544
crc64 checksum: 4E5947F1B4EDE619
name: 1
value: MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL

P28799-2
type: Modified Sequence
name: 2
based on: P28799-1
modification: VSP_001837

EC1
manual: true
source: http://purl.uniprot.org/citations/16862116
date: 2010-07-01

EC2
manual: true
source: http://purl.uniprot.org/citations/16983685
date: 2010-07-01

EC3
manual: true
source: http://purl.uniprot.org/citations/18183624
date: 2010-07-01

EC4
manual: true
source: http://purl.uniprot.org/citations/19159218
date: 2010-07-01

Q01436
type: Protein
reviewed: true
created: 1993-10-01
modified: 2010-06-15
version: 37
mnemonic: CEF_BPT4
mnemonic: YCA2_BPT4
citation: http://purl.uniprot.org/citations/1400206
citation: http://purl.uniprot.org/citations/12626685
recommended name: 513031343336003
organism: http://purl.uniprot.org/taxonomy/10665
encoded by: cef
annotation: PRO_0000164920
existence: Predicted Existence
classified with: http://purl.uniprot.org/keywords/1019
sequence: MKRKIVQNCT NDEFEDVLFD PNLVVVQKEH TSKFTHLTSV YVYEKVGDKQ PIYGVFREIT EDGTTYWKEI Y

http://purl.uniprot.org/citations/1400206
type: Journal Citation
title: Sequence and characterization of the bacteriophage T4 comC alpha gene product, a possible transcription antitermination factor.
author: Sanson B.
author: Uzan M.
date: 1992
name: J. Bacteriol.
volume: 174
pages: 6539-6547

513031343336001
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

http://purl.uniprot.org/citations/12626685
type: Journal Citation
title: Bacteriophage T4 genome.
author: Miller E.S.
author: Kutter E.
author: Mosig G.
author: Arisaka F.
author: Kunisawa T.
author: Ruger W.
date: 2003
name: Microbiol. Mol. Biol. Rev.
volume: 67
pages: 86-156

513031343336002
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

AAA32484.1
type: Nucleotide Resource
database: EMBL
located on: M89919

AAD42588.1
type: Nucleotide Resource
database: EMBL
located on: http://purl.uniprot.org/embl/AF158101

B45731
type: Resource
database: PIR

NP 049625.1
type: Resource
database: RefSeq

http://purl.uniprot.org/geneid/1258628
type: Resource
database: GeneID

AF158101 GR
type: Resource
database: GenomeReviews
comment: T4p011

CLSP2343268
type: Resource
database: ProtClustDB

513031343336003
type: Structured Name
full name: Protein cef

cef
type: Gene
alternative label: mb

PRO_0000164920
type: Chain Annotation
comment: Protein cef
range: 513031343336005

513031343336005
type: Range
begin: 1
end: 71

MKRKIVQNCT NDEFEDVLFD PNLVVVQKEH TSKFTHLTSV YVYEKVGDKQ PIYGVFREIT EDGTTYWKEI Y
type: Simple Sequence
modified: 1993-10-01
version: 1
mass: 8465
crc64 checksum: 031505CA6FE414FA