#!/usr/bin/env python # Authors: Greg Caporaso (gregcaporaso@gmail.com), Brett Easton, Gavin Huttley # test_coevolution.py """ Description File created on 22 May 2007. """ from __future__ import division from tempfile import mktemp from os import remove, environ from os.path import exists from numpy import zeros, ones, array, transpose, arange, nan, log, e, sqrt,\ greater_equal, less_equal from cogent.util.unit_test import TestCase, main from cogent import DNA, RNA, PROTEIN, LoadTree, LoadSeqs from cogent.core.alphabet import CharAlphabet from cogent.maths.stats.util import Freqs from cogent.core.profile import Profile from cogent.core.alphabet import CharAlphabet, Alphabet from cogent.maths.stats.distribution import binomial_exact from cogent.core.alignment import DenseAlignment from cogent.seqsim.tree import RandomTree from cogent.app.util import get_tmp_filename from cogent.evolve.models import DSO78_matrix, DSO78_freqs from cogent.evolve.substitution_model import SubstitutionModel, Empirical from cogent.app.gctmpca import gctmpca_aa_order,\ default_gctmpca_aa_sub_matrix from cogent.util.misc import app_path from cogent.evolve.coevolution import mi_alignment, nmi_alignment,\ resampled_mi_alignment, sca_alignment, make_weights,\ parse_gctmpca_result_line, gDefaultNullValue, create_gctmpca_input,\ build_rate_matrix, coevolve_pair, validate_position, validate_alphabet,\ validate_alignment, unpickle_coevolution_result, mi,\ parse_gctmpca_result, sca_pair, csv_to_coevolution_matrix, sca_position,\ coevolve_position, sca_input_validation, coevolve_alignment, \ probs_from_dict, pickle_coevolution_result, \ parse_coevolution_matrix_filepath, normalized_mi, n_random_seqs, \ mi_position, mi_pair, calc_pair_scale, coevolve_alignments, protein_dict,\ ignore_excludes, merge_alignments, ltm_to_symmetric, join_positions,\ is_parsimony_informative, identify_aln_positions_above_threshold, \ get_subalignments, get_positional_probabilities, \ get_positional_frequencies, get_dgg, get_dg, get_allowed_perturbations, \ freqs_to_array, freqs_from_aln, \ filter_threshold_based_multiple_interdependency, \ filter_non_parsimony_informative, filter_exclude_positions, \ coevolution_matrix_to_csv, count_le_threshold, count_ge_threshold, \ nmi_position, nmi_pair, AAGapless, ancestral_state_position, \ ancestral_state_pair, coevolve_alignments_validation, \ ancestral_state_alignment, nmi, build_coevolution_matrix_filepath,\ aln_position_pairs_cmp_threshold, validate_tree, validate_ancestral_seqs,\ validate_ancestral_seqs, get_ancestral_seqs, \ ancestral_states_input_validation, ancestral_state_pair, gctmpca_alignment,\ aln_position_pairs_ge_threshold, aln_position_pairs_ge_threshold,\ aln_position_pairs_le_threshold, gctmpca_pair __author__ = "Greg Caporaso" __copyright__ = "Copyright 2007-2012, The Cogent Project" __credits__ = ["Greg Caporaso"] __license__ = "GPL" __version__ = "1.5.3" __maintainer__ = "Greg Caporaso" __email__ = "gregcaporaso@gmail.com" __status__ = "Beta" class CoevolutionTests(TestCase): """ Tests of coevolution.py """ def setUp(self): """Set up variables for us in tests """ self.run_slow_tests = int(environ.get('TEST_SLOW_APPC',0)) self.run_gctmpca_tests = app_path('calculate_likelihood') ## Data used in SCA tests self.dna_aln = DenseAlignment(data=zip(\ range(4),['ACGT','AGCT','ACCC','TAGG']),MolType=DNA) self.rna_aln = DenseAlignment(data=zip(\ range(4),['ACGU','AGCU','ACCC','UAGG']),MolType=RNA) self.protein_aln = DenseAlignment(data=zip(\ range(4),['ACGP','AGCT','ACCC','TAGG']),MolType=PROTEIN) self.dna_aln_gapped = DenseAlignment(data=zip(range(4),\ ['A-CGT','AGC-T','-ACCC','TAGG-']),MolType=DNA) self.freq = DenseAlignment(data=zip(range(20),\ ['TCT', 'CCT', 'CCC', 'CCC',\ 'CCG', 'CC-', 'AC-', 'AC-', 'AA-', 'AA-', 'GA-', 'GA-', 'GA-', 'GA-',\ 'GA-', 'G--', 'G--', 'G--', 'G--', 'G--',]),MolType=PROTEIN) self.two_pos = DenseAlignment(data=zip(map(str,range(20)),\ ['TC', 'CC', 'CC', 'CC', 'CC', 'CC', 'AC', 'AC', \ 'AA', 'AA', 'GA', 'GA', 'GA', 'GA', 'GA', 'GT', \ 'GT', 'GT', 'GT', 'GT']),MolType=PROTEIN) self.tree20 = LoadTree(treestring=tree20_string) self.gpcr_aln = gpcr_aln self.myos_aln = myos_aln # a made-up dict of base frequencies to use as the natural freqs # for SCA calcs on DNA seqs self.dna_base_freqs = dict(zip('ACGT',[0.25]*4)) self.rna_base_freqs = dict(zip('ACGU',[0.25]*4)) self.run_slow_gctmpca_tests = False self.protein_aln4 = DenseAlignment([('A1','AACF'),('A12','AADF'),\ ('A123','ADCF'),('A111','AAD-')],\ MolType=PROTEIN) self.rna_aln4 = DenseAlignment([('A1','AAUU'),('A12','ACGU'),\ ('A123','UUAA'),('A111','AAA-')],\ MolType=RNA) self.dna_aln4 = DenseAlignment([('A1','AATT'),('A12','ACGT'),\ ('A123','TTAA'),('A111','AAA?')],\ MolType=DNA) self.tree4 = LoadTree(treestring=\ "((A1:0.5,A111:0.5):0.5,(A12:0.5,A123:0.5):0.5);") def test_alignment_analyses_moltype_protein(self): """ alignment methods work with moltype = PROTEIN """ r = mi_alignment(self.protein_aln4) self.assertEqual(r.shape,(4,4)) r = nmi_alignment(self.protein_aln4) self.assertEqual(r.shape,(4,4)) r = sca_alignment(self.protein_aln4,cutoff=0.75) self.assertEqual(r.shape,(4,4)) r = ancestral_state_alignment(self.protein_aln4,self.tree4) self.assertEqual(r.shape,(4,4)) # check if we're running the GCTMPCA tests and the slow tests if self.run_slow_tests and self.run_gctmpca_tests: r = gctmpca_alignment(self.protein_aln4,self.tree4,epsilon=0.7) self.assertEqual(r.shape,(4,4)) def test_alignment_analyses_moltype_rna(self): """ alignment methods work with moltype = RNA """ r = mi_alignment(self.rna_aln4) self.assertEqual(r.shape,(4,4)) r = nmi_alignment(self.rna_aln4) self.assertEqual(r.shape,(4,4)) r = sca_alignment(self.rna_aln4,cutoff=0.75,alphabet='ACGU',\ background_freqs=self.rna_base_freqs) self.assertEqual(r.shape,(4,4)) r = ancestral_state_alignment(self.rna_aln4,self.tree4) self.assertEqual(r.shape,(4,4)) # check if we're running the GCTMPCA tests and the slow tests if self.run_slow_tests and self.run_gctmpca_tests: r = gctmpca_alignment(self.rna_aln4,self.tree4,epsilon=0.7) self.assertEqual(r.shape,(4,4)) def test_alignment_analyses_moltype_dna(self): """ alignment methods work with moltype = DNA """ r = mi_alignment(self.dna_aln4) self.assertEqual(r.shape,(4,4)) r = nmi_alignment(self.dna_aln4) self.assertEqual(r.shape,(4,4)) r = sca_alignment(self.dna_aln4,cutoff=0.75,alphabet='ACGT',\ background_freqs=self.dna_base_freqs) self.assertEqual(r.shape,(4,4)) r = ancestral_state_alignment(self.dna_aln4,self.tree4) self.assertEqual(r.shape,(4,4)) # check if we're running the GCTMPCA tests and the slow tests if self.run_slow_tests and self.run_gctmpca_tests: # Gctmpca method doesn't support DNA alignments. self.assertRaises(ValueError,gctmpca_alignment,self.dna_aln4,\ self.tree4,epsilon=0.7) def test_join_positions(self): """ join_positions functions as expected """ self.assertEqual(join_positions(list('ABCD'),list('WXYZ')),\ ['AW','BX','CY','DZ']) self.assertEqual(join_positions(list('AAA'),list('BBB')),\ ['AB','AB','AB']) self.assertEqual(join_positions([],[]),[]) def test_mi(self): """ mi calculations function as expected with valid data""" self.assertFloatEqual(mi(1.0,1.0,1.0),1.0) self.assertFloatEqual(mi(1.0,1.0,2.0),0.0) self.assertFloatEqual(mi(1.0,1.0,1.5),0.5) def test_normalized_mi(self): """ normalized mi calculations function as expected with valid data""" self.assertFloatEqual(normalized_mi(1.0,1.0,1.0),1.0) self.assertFloatEqual(normalized_mi(1.0,1.0,2.0),0.0) self.assertFloatEqual(normalized_mi(1.0,1.0,1.5),0.3333,3) def test_mi_pair(self): """ mi_pair calculates mi from a pair of columns """ aln = DenseAlignment(data={'1':'AB','2':'AB'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), 0.0) aln = DenseAlignment(data={'1':'AB','2':'BA'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), 1.0) # order of positions doesn't matter (when it shouldn't) aln = DenseAlignment(data={'1':'AB','2':'AB'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1),\ mi_pair(aln,pos1=1,pos2=0)) aln = DenseAlignment(data={'1':'AB','2':'BA'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), \ mi_pair(aln,pos1=1,pos2=0)) def test_wrapper_functions_handle_invalid_parameters(self): """coevolve_*: functions error on missing parameters""" # missing cutoff aln = DenseAlignment(data={'1':'AC','2':'AC'},MolType=PROTEIN) self.assertRaises(ValueError,coevolve_pair,sca_pair,aln,0,1) self.assertRaises(ValueError,coevolve_position,sca_position,aln,0) self.assertRaises(ValueError,coevolve_alignment,sca_alignment,aln) self.assertRaises(ValueError,coevolve_alignments,sca_alignment,aln,aln) def test_coevolve_pair(self): """coevolve_pair: returns same as pair methods called directly """ aln = DenseAlignment(data={'1':'AC','2':'AC'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') cutoff = 0.50 # mi_pair == coevolve_pair(mi_pair,...) self.assertFloatEqual(coevolve_pair(mi_pair,aln,pos1=0,pos2=1),\ mi_pair(aln,pos1=0,pos2=1)) self.assertFloatEqual(coevolve_pair(nmi_pair,aln,pos1=0,pos2=1),\ nmi_pair(aln,pos1=0,pos2=1)) self.assertFloatEqual(coevolve_pair(ancestral_state_pair,aln,pos1=0,\ pos2=1,tree=t),ancestral_state_pair(aln,pos1=0,pos2=1,tree=t)) self.assertFloatEqual(coevolve_pair(sca_pair,aln,pos1=0,\ pos2=1,cutoff=cutoff),sca_pair(aln,pos1=0,pos2=1,cutoff=cutoff)) def test_coevolve_position(self): """coevolve_position: returns same as position methods called directly """ aln = DenseAlignment(data={'1':'AC','2':'AC'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') cutoff = 0.50 # mi_position == coevolve_position(mi_position,...) self.assertFloatEqual(coevolve_position(mi_position,aln,position=0),\ mi_position(aln,position=0)) self.assertFloatEqual(coevolve_position(nmi_position,aln,position=0),\ nmi_position(aln,position=0)) self.assertFloatEqual(coevolve_position(\ ancestral_state_position,aln,position=0,\ tree=t),ancestral_state_position(aln,position=0,tree=t)) self.assertFloatEqual(coevolve_position(sca_position,aln,position=0,\ cutoff=cutoff),sca_position(aln,position=0,cutoff=cutoff)) def test_coevolve_alignment(self): """coevolve_alignment: returns same as alignment methods""" aln = DenseAlignment(data={'1':'AC','2':'AC'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') cutoff = 0.50 # mi_alignment == coevolve_alignment(mi_alignment,...) self.assertFloatEqual(coevolve_alignment(mi_alignment,aln),\ mi_alignment(aln)) self.assertFloatEqual(coevolve_alignment(mip_alignment,aln),\ mip_alignment(aln)) self.assertFloatEqual(coevolve_alignment(mia_alignment,aln),\ mia_alignment(aln)) self.assertFloatEqual(coevolve_alignment(nmi_alignment,aln),\ nmi_alignment(aln)) self.assertFloatEqual(coevolve_alignment(ancestral_state_alignment,aln,\ tree=t),ancestral_state_alignment(aln,tree=t)) self.assertFloatEqual(coevolve_alignment(sca_alignment,aln,\ cutoff=cutoff),sca_alignment(aln,cutoff=cutoff)) def test_coevolve_alignments_validation_idenifiers(self): """coevolve_alignments_validation: seq/tree validation functions """ method = sca_alignment aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') # OK w/ no tree coevolve_alignments_validation(method,aln1,aln2,2,None) # OK w/ tree coevolve_alignments_validation(method,aln1,aln2,2,None,tree=t) # If there is a plus present in identifiers, we only care about the # text before the colon aln1 = DenseAlignment(data={'1+a':'AC','2+b':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(\ data={'1 + c':'EFW','2 + d':'EGY'},MolType=PROTEIN) t = LoadTree(treestring='(1+e:0.5,2 + f:0.5);') # OK w/ no tree coevolve_alignments_validation(method,aln1,aln2,2,None) # OK w/ tree coevolve_alignments_validation(method,aln1,aln2,2,None,tree=t) # mismatch b/w alignments seq names aln1 = DenseAlignment(data={'3':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') self.assertRaises(AssertionError,coevolve_alignments_validation,\ method,aln1,aln2,2,None,tree=t) # mismatch b/w alignments and tree seq names aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) t = LoadTree(treestring='(3:0.5,2:0.5);') self.assertRaises(AssertionError,\ coevolve_alignments_validation,method,\ aln1,aln2,2,None,tree=t) # mismatch b/w alignments in number of seqs aln1 = DenseAlignment(\ data={'1':'AC','2':'AD','3':'AA'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') self.assertRaises(AssertionError,coevolve_alignments_validation,\ method,aln1,aln2,2,None) self.assertRaises(AssertionError,coevolve_alignments_validation,\ method,aln1,aln2,2,None,tree=t) # mismatch b/w alignments & tree in number of seqs aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,(2:0.5,3:0.25));') self.assertRaises(AssertionError,coevolve_alignments_validation,\ method,aln1,aln2,2,None,tree=t) def test_coevolve_alignments_validation_min_num_seqs(self): """coevolve_alignments_validation: ValueError on fewer than min_num_seqs """ method = mi_alignment # too few sequences -> ValueError aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) coevolve_alignments_validation(method,aln1,aln2,1,None) coevolve_alignments_validation(method,aln1,aln2,2,None) self.assertRaises(ValueError,\ coevolve_alignments_validation,method,aln1,aln2,3,None) def test_coevolve_alignments_validation_max_num_seqs(self): """coevolve_alignments_validation: min_num_seqs <= max_num_seqs """ method = mi_alignment # min_num_seqs > max_num_seqs-> ValueError aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) coevolve_alignments_validation(method,aln1,aln2,1,None) coevolve_alignments_validation(method,aln1,aln2,1,3) coevolve_alignments_validation(method,aln1,aln2,2,3) self.assertRaises(ValueError,\ coevolve_alignments_validation,method,aln1,aln2,3,2) def test_coevolve_alignments_validation_moltypes(self): """coevolve_alignments_validation: valid for acceptable MolTypes """ aln1 = DenseAlignment(data={'1':'AC','2':'AU'},MolType=RNA) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) # different MolType coevolve_alignments_validation(mi_alignment,aln1,aln2,2,None) coevolve_alignments_validation(nmi_alignment,aln1,aln2,2,None) coevolve_alignments_validation(\ resampled_mi_alignment,aln1,aln2,2,None) self.assertRaises(AssertionError,coevolve_alignments_validation,\ sca_alignment,aln1,aln2,2,None) self.assertRaises(AssertionError,coevolve_alignments_validation,\ ancestral_state_alignment,aln1,aln2,2,None) self.assertRaises(AssertionError,coevolve_alignments_validation,\ gctmpca_alignment,aln1,aln2,2,None) def test_coevolve_alignments(self): """ coevolve_alignments: returns correct len(aln1) x len(aln2) matrix """ aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) combined_aln =\ DenseAlignment(data={'1':'ACEFW','2':'ADEGY'},MolType=PROTEIN) t = LoadTree(treestring='(1:0.5,2:0.5);') cutoff = 0.50 # MI m = mi_alignment(combined_aln) expected = array([[m[2,0],m[2,1]],\ [m[3,0],m[3,1]],[m[4,0],m[4,1]]]) self.assertFloatEqual(coevolve_alignments(mi_alignment,aln1,aln2),\ expected) # MI (return_full=True) self.assertFloatEqual(coevolve_alignments(mi_alignment,aln1,aln2,\ return_full=True),m) # NMI m = nmi_alignment(combined_aln) expected = array([[m[2,0],m[2,1]],\ [m[3,0],m[3,1]],[m[4,0],m[4,1]]]) self.assertFloatEqual(coevolve_alignments(nmi_alignment,aln1,aln2),\ expected) # AS m = ancestral_state_alignment(combined_aln,tree=t) expected = array([[m[2,0],m[2,1]],\ [m[3,0],m[3,1]],[m[4,0],m[4,1]]]) self.assertFloatEqual(\ coevolve_alignments(ancestral_state_alignment,aln1,aln2,\ tree=t),expected) # SCA m = sca_alignment(combined_aln,cutoff=cutoff) expected = array([[m[2,0],m[2,1]],\ [m[3,0],m[3,1]],[m[4,0],m[4,1]]]) self.assertFloatEqual(coevolve_alignments(sca_alignment,aln1,aln2,\ cutoff=cutoff),expected) def test_coevolve_alignments_watches_min_num_seqs(self): """ coevolve_alignments: error on too few sequences """ aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) coevolve_alignments(mi_alignment,aln1,aln2) coevolve_alignments(mi_alignment,aln1,aln2,min_num_seqs=0) coevolve_alignments(mi_alignment,aln1,aln2,min_num_seqs=1) coevolve_alignments(mi_alignment,aln1,aln2,min_num_seqs=2) self.assertRaises(ValueError,\ coevolve_alignments,mi_alignment,aln1,aln2,min_num_seqs=3) self.assertRaises(ValueError,\ coevolve_alignments,mi_alignment,aln1,aln2,min_num_seqs=50) def test_coevolve_alignments_watches_max_num_seqs(self): """ coevolve_alignments: filtering or error on too many sequences """ aln1 = DenseAlignment(data={'1':'AC','2':'AD','3':'YP'},\ MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'ACP','2':'EAD','3':'PYP'},\ MolType=PROTEIN) # keep all seqs tmp_filepath = get_tmp_filename(\ prefix='tmp_test_coevolution',suffix='.fasta') coevolve_alignments(mi_alignment,aln1,aln2,max_num_seqs=3,\ merged_aln_filepath=tmp_filepath) self.assertEqual(LoadSeqs(tmp_filepath).getNumSeqs(),3) # keep 2 seqs coevolve_alignments(mi_alignment,aln1,aln2,max_num_seqs=2,\ merged_aln_filepath=tmp_filepath) self.assertEqual(LoadSeqs(tmp_filepath).getNumSeqs(),2) # error if no sequence filter self.assertRaises(ValueError,\ coevolve_alignments,mi_alignment,aln1,aln2,max_num_seqs=2,\ merged_aln_filepath=tmp_filepath,sequence_filter=None) # clean up the temporary file remove(tmp_filepath) def test_coevolve_alignments_different_MolType(self): """ coevolve_alignments: different MolTypes supported """ aln1 = DenseAlignment(data={'1':'AC','2':'AU'},MolType=RNA) aln2 = DenseAlignment(data={'1':'EFW','2':'EGY'},MolType=PROTEIN) combined_aln = DenseAlignment(data={'1':'ACEFW','2':'AUEGY'}) t = LoadTree(treestring='(1:0.5,2:0.5);') cutoff = 0.50 # MI m = mi_alignment(combined_aln) expected = array([[m[2,0],m[2,1]],\ [m[3,0],m[3,1]],[m[4,0],m[4,1]]]) self.assertFloatEqual(coevolve_alignments(mi_alignment,aln1,aln2),\ expected) # MI (return_full=True) self.assertFloatEqual(coevolve_alignments(mi_alignment,aln1,aln2,\ return_full=True),m) # NMI m = nmi_alignment(combined_aln) expected = array([[m[2,0],m[2,1]],\ [m[3,0],m[3,1]],[m[4,0],m[4,1]]]) self.assertFloatEqual(coevolve_alignments(nmi_alignment,aln1,aln2),\ expected) def test_mi_pair_cols_default_exclude_handling(self): """ mi_pair returns null_value on excluded by default """ aln = DenseAlignment(data={'1':'AB','2':'-B'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), gDefaultNullValue) aln = DenseAlignment(data={'1':'-B','2':'-B'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), gDefaultNullValue) aln = DenseAlignment(data={'1':'AA','2':'-B'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), gDefaultNullValue) aln = DenseAlignment(data={'1':'AA','2':'PB'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1,excludes='P'),\ gDefaultNullValue) def test_mi_pair_cols_non_default_exclude_handling(self): """ mi_pair uses non-default exclude_handler when provided""" aln = DenseAlignment(data={'1':'A-','2':'A-'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1), gDefaultNullValue) self.assertFloatEqual(\ mi_pair(aln,pos1=0,pos2=1,exclude_handler=ignore_excludes),0.0) def test_mi_pair_cols_and_entropies(self): """ mi_pair calculates mi from a pair of columns and precalc entropies """ aln = DenseAlignment(data={'1':'AB','2':'AB'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1,h1=0.0,h2=0.0), 0.0) aln = DenseAlignment(data={'1':'AB','2':'BA'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1,h1=1.0,h2=1.0), 1.0) # incorrect positional entropies provided to ensure that the # precalculated values are used, and that entorpies are not # caluclated on-the-fly. aln = DenseAlignment(data={'1':'AB','2':'AB'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1,h1=1.0,h2=1.0), 2.0) def test_mi_pair_alt_calculator(self): """ mi_pair uses alternate mi_calculator when provided """ aln = DenseAlignment(data={'1':'AB','2':'AB'},MolType=PROTEIN) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1),0.0) self.assertFloatEqual(mi_pair(aln,pos1=0,pos2=1,\ mi_calculator=normalized_mi),gDefaultNullValue) def test_mi_position_valid_input(self): """ mi_position functions with varied valid input """ aln = DenseAlignment(data={'1':'ACG','2':'GAC'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,0),array([1.0,1.0,1.0])) aln = DenseAlignment(data={'1':'ACG','2':'ACG'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,0),array([0.0,0.0,0.0])) aln = DenseAlignment(data={'1':'ACG','2':'ACG'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,2),array([0.0,0.0,0.0])) def test_mi_position_from_alignment_nmi(self): """mi_position functions w/ alternate mi_calculator """ aln = DenseAlignment(data={'1':'ACG','2':'ACG'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,0),array([0.0,0.0,0.0])) aln = DenseAlignment(data={'1':'ACG','2':'ACG'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,0,mi_calculator=normalized_mi),\ array([gDefaultNullValue,gDefaultNullValue,gDefaultNullValue])) def test_mi_position_from_alignment_default_exclude_handling(self): """ mi_position handles excludes by setting to null_value""" aln = DenseAlignment(data={'1':'ACG','2':'G-C'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,0),\ array([1.0,gDefaultNullValue,1.0])) aln = DenseAlignment(data={'1':'ACG','2':'GPC'},MolType=PROTEIN) self.assertFloatEqual(mi_position(aln,0,excludes='P'),\ array([1.0,gDefaultNullValue,1.0])) def test_mi_position_from_alignment_non_default_exclude_handling(self): """ mi_position handles excludes w/ non-default method""" aln = DenseAlignment(data={'1':'ACG','2':'G-C'},MolType=PROTEIN) self.assertFloatEqual(\ mi_position(aln,0,exclude_handler=ignore_excludes),\ array([1.0,1.0,1.0])) def test_mi_alignment_excludes(self): """ mi_alignment handles excludes properly """ expected = array([[0.0, gDefaultNullValue, 0.0],\ [gDefaultNullValue,gDefaultNullValue,gDefaultNullValue],\ [0.0,gDefaultNullValue,0.0]]) # gap in second column aln = DenseAlignment(data={'1':'ACG','2':'A-G'},MolType=PROTEIN) self.assertFloatEqual(mi_alignment(aln),expected) # excludes = 'P' aln = DenseAlignment(data={'1':'ACG','2':'APG'},MolType=PROTEIN) self.assertFloatEqual(mi_alignment(aln,excludes='P'),\ expected) # gap in first column expected = array([\ [gDefaultNullValue, gDefaultNullValue, gDefaultNullValue],\ [gDefaultNullValue,0.0,0.0], [gDefaultNullValue,0.0,0.0]]) aln = DenseAlignment(data={'1':'-CG','2':'ACG'},MolType=PROTEIN) self.assertFloatEqual(mi_alignment(aln),expected) def test_mi_alignment_high(self): """ mi_alignment detected perfectly correlated columns """ expected = [[1.0, 1.0],[1.0,1.0]] aln = DenseAlignment(data={'1':'AG','2':'GA'},MolType=PROTEIN) self.assertFloatEqual(mi_alignment(aln),expected) def test_mi_alignment_low(self): """ mi_alignment detected in perfectly uncorrelated columns """ expected = [[0.0, 0.0],[0.0,1.0]] aln = DenseAlignment(data={'1':'AG','2':'AC'},MolType=PROTEIN) self.assertFloatEqual(mi_alignment(aln),expected) def test_resampled_mi_alignment(self): """ resampled_mi_alignment returns without error """ aln = DenseAlignment(data={'1':'ACDEF','2':'ACFEF','3':'ACGEF'},\ MolType=PROTEIN) resampled_mi_alignment(aln) aln = DenseAlignment(data={'1':'ACDEF','2':'ACF-F','3':'ACGEF'},\ MolType=PROTEIN) resampled_mi_alignment(aln) def test_coevolve_alignment(self): """ coevolve_alignment functions as expected with varied input """ aln1 = DenseAlignment(data={'1':'ACDEF','2':'ACFEF','3':'ACGEF'},\ MolType=PROTEIN) # no kwargs passed self.assertFloatEqual(coevolve_alignment(mi_alignment,aln1),\ mi_alignment(aln1)) # different method passed self.assertFloatEqual(coevolve_alignment(nmi_alignment,aln1),\ nmi_alignment(aln1)) # kwargs passed self.assertFloatEqual(coevolve_alignment(mi_alignment,aln1,\ mi_calculator=nmi),nmi_alignment(aln1)) def test_build_coevolution_matrix_filepath(self): """ build_coevolution_matrix_filepath functions w/ varied input """ self.assertEqual(build_coevolution_matrix_filepath(\ './blah.fasta'),'./blah') self.assertEqual(build_coevolution_matrix_filepath(\ 'blah.fasta'),'./blah') self.assertEqual(build_coevolution_matrix_filepath('blah'),'./blah') self.assertEqual(build_coevolution_matrix_filepath('./blah'),'./blah') self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh/',method='xx',alphabet='yyy'),\ './duh/blah.yyy.xx') self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh/',method='xx',alphabet='yyy',\ parameter=0.25),\ './duh/blah.yyy.xx') self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh/',method='xx'),'./duh/blah.xx') self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh/',method='sca',parameter=0.25),\ './duh/blah.sca_25') self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh/',method='sca',parameter=0.25,\ alphabet='xx'),'./duh/blah.xx.sca_25') # no trailing / to output_dir self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh',method='sca',parameter=0.25,\ alphabet='xx'),'./duh/blah.xx.sca_25') self.assertEqual(build_coevolution_matrix_filepath('./blah.fasta',\ output_dir='./duh/',method='gctmpca',parameter=0.25),\ './duh/blah.gctmpca_25') self.assertRaises(ValueError,build_coevolution_matrix_filepath,\ './blah.fasta','./duh/','gctmpca') self.assertRaises(ValueError,build_coevolution_matrix_filepath,\ './blah.fasta','./duh/','sca') self.assertRaises(ValueError,build_coevolution_matrix_filepath,\ './blah.fasta','./duh/','sca','xx') def test_pickle_coevolution_result_error(self): """pickle matrix: IOError handled correctly""" m = array([[1,2],[3,4]]) self.assertRaises(IOError,pickle_coevolution_result,m,'') def test_unpickle_coevolution_result_error(self): """unpickle matrix: IOError handled correctly""" self.assertRaises(IOError,unpickle_coevolution_result,\ 'invalid/file/path.pkl') def test_pickle_and_unpickle(self): """unpickle(pickle(matrix)) == matrix""" for expected in [4.5,array([1.2,4.3,5.5]),\ array([[1.4,2.2],[3.0,0.4]])]: filepath = mktemp() pickle_coevolution_result(expected,filepath) actual = unpickle_coevolution_result(filepath) self.assertFloatEqual(actual,expected) remove(filepath) def test_csv_coevolution_result_error(self): """matrix -> csv: IOError handled correctly""" m = array([[1,2],[3,4]]) self.assertRaises(IOError,coevolution_matrix_to_csv,m,'') def test_uncsv_coevolution_result_error(self): """csv -> matrix: IOError handled correctly""" self.assertRaises(IOError,csv_to_coevolution_matrix,\ 'invalid/file/path.pkl') def test_csv_and_uncsv(self): """converting to/from csv matrix results in correct coevolution matrix """ expected = array([[1.4,2.2],[gDefaultNullValue,0.4]]) filepath = mktemp() coevolution_matrix_to_csv(expected,filepath) actual = csv_to_coevolution_matrix(filepath) self.assertFloatEqual(actual,expected) remove(filepath) def test_parse_coevolution_matrix_filepath(self): """Parsing matrix filepaths works as expected. """ expected = ('myosin_995', 'a1_4', 'nmi') self.assertEqual(\ parse_coevolution_matrix_filepath('pkls/myosin_995.a1_4.nmi.pkl'),\ expected) self.assertEqual(\ parse_coevolution_matrix_filepath('pkls/myosin_995.a1_4.nmi.csv'),\ expected) expected = ('p53','orig','mi') self.assertEqual(\ parse_coevolution_matrix_filepath('p53.orig.mi.pkl'),\ expected) self.assertEqual(\ parse_coevolution_matrix_filepath('p53.orig.mi.csv'),\ expected) def test_parse_coevolution_matrix_filepath_error(self): """Parsing matrix file paths handles invalid filepaths """ self.assertRaises(ValueError,\ parse_coevolution_matrix_filepath,'pkls/myosin_995.nmi.pkl') self.assertRaises(ValueError,\ parse_coevolution_matrix_filepath,'pkls/myosin_995.pkl') self.assertRaises(ValueError,\ parse_coevolution_matrix_filepath,'pkls/myosin_995') self.assertRaises(ValueError,\ parse_coevolution_matrix_filepath,'') def test_identify_aln_positions_above_threshold(self): """Extracting scores above threshold works as expected """ m = array([\ [gDefaultNullValue,gDefaultNullValue,\ gDefaultNullValue,gDefaultNullValue],\ [0.3, 1.0,gDefaultNullValue,gDefaultNullValue],\ [0.25,0.75,1.0,gDefaultNullValue], [0.9,0.751,0.8,1.0]]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,0),[]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,1),\ [1]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,2),\ [1,2]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,3),\ [0,1,2,3]) m = ltm_to_symmetric(m) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,0),\ [3]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,1),\ [1,2,3]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,2),\ [1,2,3]) self.assertEqual(identify_aln_positions_above_threshold(m,0.75,3),\ [0,1,2,3]) self.assertEqual(identify_aln_positions_above_threshold(m,1.1,0),\ []) self.assertEqual(identify_aln_positions_above_threshold(m,-5.,0),\ [1,2,3]) self.assertEqual(identify_aln_positions_above_threshold(m,-5.,1),\ [0,1,2,3]) def test_count_ge_threshold(self): """count_ge_threshold works as expected """ m = array([[gDefaultNullValue]*3]*3) self.assertEqual(count_ge_threshold(m,1.0),(0,0)) self.assertEqual(count_ge_threshold(m,\ gDefaultNullValue,gDefaultNullValue),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,42),(0,9)) m = array([[0,1,2],[3,4,5],[6,7,8]]) self.assertEqual(count_ge_threshold(m,4),(5,9)) self.assertEqual(count_ge_threshold(m,8),(1,9)) self.assertEqual(count_ge_threshold(m,9),(0,9)) m = array([[0,gDefaultNullValue,gDefaultNullValue],\ [gDefaultNullValue,4,5],[6,7,8]]) self.assertEqual(count_ge_threshold(m,4),(5,6)) self.assertEqual(count_ge_threshold(m,8),(1,6)) self.assertEqual(count_ge_threshold(m,9),(0,6)) def test_count_le_threshold(self): """count_le_threshold works as expected """ m = array([[gDefaultNullValue]*3]*3) self.assertEqual(count_le_threshold(m,1.0),(0,0)) self.assertEqual(count_le_threshold(m,\ gDefaultNullValue,gDefaultNullValue),(0,0)) self.assertEqual(count_le_threshold(m,1.0,42),(0,9)) m = array([[0,1,2],[3,4,5],[6,7,8]]) self.assertEqual(count_le_threshold(m,4),(5,9)) self.assertEqual(count_le_threshold(m,8),(9,9)) self.assertEqual(count_le_threshold(m,9),(9,9)) m = array([[0,gDefaultNullValue,gDefaultNullValue],\ [gDefaultNullValue,4,5],[6,7,8]]) self.assertEqual(count_le_threshold(m,4),(2,6)) self.assertEqual(count_le_threshold(m,8),(6,6)) self.assertEqual(count_le_threshold(m,9),(6,6)) def test_count_ge_threshold_symmetric_ignore_diagonal(self): """count_ge_threshold works with symmetric and/or ignoring diag = True """ # no good scores, varied null value m = array([[gDefaultNullValue]*3]*3) self.assertEqual(count_ge_threshold(m,1.0,symmetric=True),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,symmetric=True),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,42,symmetric=True),(0,6)) self.assertEqual(count_ge_threshold(m,1.0,ignore_diagonal=True),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,ignore_diagonal=True),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,42,\ ignore_diagonal=True),(0,6)) self.assertEqual(count_ge_threshold(m,1.0,\ ignore_diagonal=True,symmetric=True),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,\ ignore_diagonal=True,symmetric=True),(0,0)) self.assertEqual(count_ge_threshold(m,1.0,42,\ ignore_diagonal=True,symmetric=True),(0,3)) # no null values, varied other values m = array([[0,1,2],[3,4,5],[6,7,8]]) self.assertEqual(count_ge_threshold(m,4),(5,9)) self.assertEqual(count_ge_threshold(m,4,symmetric=True),(4,6)) self.assertEqual(count_ge_threshold(m,4,ignore_diagonal=True),(3,6)) self.assertEqual(count_ge_threshold(m,4,symmetric=True,\ ignore_diagonal=True),(2,3)) # null and mixed values m = array([\ [0,gDefaultNullValue,gDefaultNullValue],\ [3,4,gDefaultNullValue],\ [gDefaultNullValue,7,8]]) self.assertEqual(count_ge_threshold(m,4),(3,5)) self.assertEqual(count_ge_threshold(m,4,symmetric=True),(3,5)) self.assertEqual(count_ge_threshold(m,4,ignore_diagonal=True),(1,2)) self.assertEqual(count_ge_threshold(m,4,symmetric=True,\ ignore_diagonal=True),(1,2)) def test_count_le_threshold_symmetric_ignore_diagonal(self): """count_le_threshold works with symmetric and/or ignoring diag = True """ # varied null value m = array([[gDefaultNullValue]*3]*3) self.assertEqual(count_le_threshold(m,1.0,symmetric=True),(0,0)) self.assertEqual(count_le_threshold(m,1.0,symmetric=True),(0,0)) self.assertEqual(count_le_threshold(m,1.0,42,symmetric=True),(0,6)) self.assertEqual(count_le_threshold(m,1.0,ignore_diagonal=True),(0,0)) self.assertEqual(count_le_threshold(m,1.0,ignore_diagonal=True),(0,0)) self.assertEqual(count_le_threshold(m,1.0,42,\ ignore_diagonal=True),(0,6)) self.assertEqual(count_le_threshold(m,1.0,\ ignore_diagonal=True,symmetric=True),(0,0)) self.assertEqual(count_le_threshold(m,1.0,\ ignore_diagonal=True,symmetric=True),(0,0)) self.assertEqual(count_le_threshold(m,1.0,42,\ ignore_diagonal=True,symmetric=True),(0,3)) # no null values, varied other values m = array([[0,1,2],[3,4,5],[6,7,8]]) self.assertEqual(count_le_threshold(m,4),(5,9)) self.assertEqual(count_le_threshold(m,4,symmetric=True),(3,6)) self.assertEqual(count_le_threshold(m,4,ignore_diagonal=True),(3,6)) self.assertEqual(count_le_threshold(m,4,symmetric=True,\ ignore_diagonal=True),(1,3)) # null and mixed values m = array([\ [0,gDefaultNullValue,gDefaultNullValue],\ [3,4,gDefaultNullValue],\ [gDefaultNullValue,7,8]]) self.assertEqual(count_le_threshold(m,4),(3,5)) self.assertEqual(count_le_threshold(m,4,symmetric=True),(3,5)) self.assertEqual(count_le_threshold(m,4,ignore_diagonal=True),(1,2)) self.assertEqual(count_le_threshold(m,4,symmetric=True,\ ignore_diagonal=True),(1,2)) def test_aln_position_pairs_cmp_threshold_intramolecular(self): """aln_position_pairs_ge_threshold: intramolecular matrix """ m = array([\ [0,gDefaultNullValue,gDefaultNullValue],\ [3,4,gDefaultNullValue],\ [gDefaultNullValue,7,8]]) # cmp_function = ge self.assertEqual(aln_position_pairs_cmp_threshold(m,3.5,greater_equal),\ [(1,1),(2,1),(2,2)]) # cmp_function = greater_equal, alt null_value self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,greater_equal,null_value=4),\ [(2,1),(2,2)]) # cmp_function = le self.assertEqual(aln_position_pairs_cmp_threshold(m,3.5,less_equal),\ [(0,0),(1,0)]) # results equal results with wrapper functions self.assertEqual(aln_position_pairs_cmp_threshold(m,3.5,greater_equal),\ aln_position_pairs_ge_threshold(m,3.5)) self.assertEqual(aln_position_pairs_cmp_threshold(m,3.5,less_equal),\ aln_position_pairs_le_threshold(m,3.5)) self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,greater_equal,null_value=4),\ aln_position_pairs_ge_threshold(m,3.5,null_value=4)) self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,less_equal,null_value=0),\ aln_position_pairs_le_threshold(m,3.5,null_value=0)) def test_aln_position_pairs_ge_threshold_intermolecular(self): """aln_position_pairs_ge_threshold: intermolecular matrix """ m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) # error if failed to specify intermolecular_data_only=True self.assertRaises(AssertionError,aln_position_pairs_cmp_threshold,\ m,3.5,greater_equal) # cmp_function = ge self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,greater_equal,intermolecular_data_only=True),\ [(1,4),(2,4),(0,5),(1,5),(2,5),(3,5)]) # cmp_function = greater_equal, alt null_value self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,greater_equal,null_value=18.,intermolecular_data_only=True),\ [(1,4),(2,4),(0,5),(2,5),(3,5)]) # cmp_function = le self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,less_equal,intermolecular_data_only=True),\ [(0,4),(3,4)]) # results equal results with wrapper functions self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,greater_equal,intermolecular_data_only=True),\ aln_position_pairs_ge_threshold(m,3.5,intermolecular_data_only=True)) self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,less_equal,intermolecular_data_only=True),\ aln_position_pairs_le_threshold(m,3.5,intermolecular_data_only=True)) self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,greater_equal,null_value=4.,intermolecular_data_only=True),\ aln_position_pairs_ge_threshold(m,3.5,null_value=4.,\ intermolecular_data_only=True)) self.assertEqual(aln_position_pairs_cmp_threshold(\ m,3.5,less_equal,null_value=18.,intermolecular_data_only=True),\ aln_position_pairs_le_threshold(m,3.5,null_value=18.,\ intermolecular_data_only=True)) def test_is_parsimony_informative_strict(self): """ is_parsimony_informative functions as expected with strict=True """ freqs = {'A':25} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':25,'-':25} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':25,'?':25} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':25,'B':1} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':1,'B':1,'C':1,'D':1,'E':1} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':2,'B':1,'C':1,'D':1,'E':1} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':2,'B':2,'C':1,'D':1,'E':1} self.assertFalse(is_parsimony_informative(freqs,strict=True)) freqs = {'A':25,'B':2} self.assertTrue(is_parsimony_informative(freqs,strict=True)) freqs = {'A':2,'B':2,'C':2,'D':2,'E':2} self.assertTrue(is_parsimony_informative(freqs,strict=True)) def test_is_parsimony_informative_non_strict(self): """ is_parsimony_informative functions as expected with strict=False """ freqs = {'A':25} self.assertFalse(is_parsimony_informative(freqs,strict=False)) freqs = {'A':25,'-':25} self.assertFalse(is_parsimony_informative(freqs,strict=False)) freqs = {'A':25,'?':25} self.assertFalse(is_parsimony_informative(freqs,strict=False)) freqs = {'A':25,'B':1} self.assertFalse(is_parsimony_informative(freqs,strict=False)) freqs = {'A':1,'B':1,'C':1,'D':1,'E':1} self.assertFalse(is_parsimony_informative(freqs,strict=False)) freqs = {'A':2,'B':1,'C':1,'D':1,'E':1} self.assertFalse(is_parsimony_informative(freqs,strict=False)) freqs = {'A':2,'B':2,'C':1,'D':1,'E':1} self.assertTrue(is_parsimony_informative(freqs,strict=False)) freqs = {'A':25,'B':2} self.assertTrue(is_parsimony_informative(freqs,strict=False)) freqs = {'A':2,'B':2,'C':2,'D':2,'E':2} self.assertTrue(is_parsimony_informative(freqs,strict=False)) def test_is_parsimony_informative_non_default(self): """ is_parsimony_informative functions w non default paramters """ ## NEED TO UPDATE THESE TESTS BASED ON MY ERROR IN THE ## DEFINITION OF PARSIMONY INFORMATIVE. # changed minimum_count freqs = {'A':25,'B':2} self.assertFalse(is_parsimony_informative(freqs,\ minimum_count=3,strict=False)) freqs = {'A':25,'B':1} self.assertTrue(is_parsimony_informative(freqs,\ minimum_count=1,strict=False)) # different value of strict yields different results freqs = {'A':25,'B':2,'C':3} self.assertTrue(is_parsimony_informative(freqs,\ minimum_count=3,strict=False)) self.assertFalse(is_parsimony_informative(freqs,\ minimum_count=3,strict=True)) # changed minimum_differences freqs = {'A':25,'B':25} self.assertFalse(is_parsimony_informative(\ freqs,minimum_differences=3,strict=False)) freqs = {'A':25} self.assertTrue(is_parsimony_informative(\ freqs,minimum_differences=1,strict=False)) # changed ignored freqs = {'A':25,'-':25,'?':25} self.assertTrue(is_parsimony_informative(freqs,ignored=None,\ strict=False)) freqs = {'A':25,'?':25} self.assertTrue(is_parsimony_informative(freqs,ignored='',\ strict=False)) freqs = {'A':25,'-':25} self.assertTrue(is_parsimony_informative(freqs,ignored=None,\ strict=False)) freqs = {'A':25,'C':25} self.assertFalse(is_parsimony_informative(freqs,ignored='A',\ strict=False)) def test_filter_non_parsimony_informative_intramolecular(self): """ non-parsimony informative sites in intramolecular matrix -> null """ aln = LoadSeqs(data={'1':'ACDE','2':'ACDE','3':'ACDE','4':'ACDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[gDefaultNullValue]*4]*4) filter_non_parsimony_informative(aln,m) self.assertFloatEqual(m,expected) aln = LoadSeqs(data={'1':'ACDE','2':'FCDE','3':'ACDE','4':'FCDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[42.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[gDefaultNullValue]*4]*4) expected[0,0] = 42. filter_non_parsimony_informative(aln,m) self.assertFloatEqual(m,expected) def test_filter_non_parsimony_informative_intermolecular(self): """ non-parsimony informative sites in intermolecular matrix -> null """ # all non-parsimony informative aln = LoadSeqs(data={'1':'ACDEWQ','2':'ACDEWQ','3':'ACDEWQ','4':'ACDEWQ'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[gDefaultNullValue]*4]*2) filter_non_parsimony_informative(aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) # one non-parsimony informative pair of positions aln = LoadSeqs(data={'1':'FCDEWD','2':'ACDEWQ','3':'ACDEWD','4':'FCDEWQ'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[gDefaultNullValue]*4]*2) expected[1,0] = 9. filter_non_parsimony_informative(aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) # all parsimony informative aln = LoadSeqs(data={'1':'FFFFFF','2':'FFFFFF','3':'GGGGGG','4':'GGGGGG'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) filter_non_parsimony_informative(aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) def test_filter_exclude_positions_intramolecular(self): """filter_exclude_positions: functions for intramolecular data """ # filter zero positions (no excludes) aln = LoadSeqs(data={'1':'WCDE','2':'ACDE','3':'ACDE','4':'ACDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) filter_exclude_positions(aln,m) self.assertFloatEqual(m,expected) # filter zero positions (max_exclude_percentage = percent exclude) aln = LoadSeqs(data={'1':'-CDE','2':'A-DE','3':'AC-E','4':'ACD-'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) filter_exclude_positions(aln,m,max_exclude_percent=0.25) self.assertFloatEqual(m,expected) # filter zero positions (max_exclude_percentage too high) aln = LoadSeqs(data={'1':'-CDE','2':'A-DE','3':'AC-E','4':'ACD-'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) filter_exclude_positions(aln,m,max_exclude_percent=0.5) self.assertFloatEqual(m,expected) # filter one position (defualt max_exclude_percentage) aln = LoadSeqs(data={'1':'-CDE','2':'ACDE','3':'ACDE','4':'ACDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[gDefaultNullValue]*4,[gDefaultNullValue,18.,5.,6.], [gDefaultNullValue,1.,3.,2.],[gDefaultNullValue,0.,1.,33.]]) filter_exclude_positions(aln,m) self.assertFloatEqual(m,expected) # filter one position (non-defualt max_exclude_percentage) aln = LoadSeqs(data={'1':'-CDE','2':'ACDE','3':'ACDE','4':'-CDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[gDefaultNullValue]*4,[gDefaultNullValue,18.,5.,6.], [gDefaultNullValue,1.,3.,2.],[gDefaultNullValue,0.,1.,33.]]) filter_exclude_positions(aln,m,max_exclude_percent=0.49) self.assertFloatEqual(m,expected) # filter all positions (defualt max_exclude_percentage) aln = LoadSeqs(data={'1':'----','2':'ACDE','3':'ACDE','4':'ACDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[gDefaultNullValue]*4]*4) filter_exclude_positions(aln,m) self.assertFloatEqual(m,expected) # filter all positions (non-defualt max_exclude_percentage) aln = LoadSeqs(data={'1':'----','2':'A-DE','3':'AC--','4':'-CDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,3.]]) expected = array([[gDefaultNullValue]*4]*4) filter_exclude_positions(aln,m,max_exclude_percent=0.49) self.assertFloatEqual(m,expected) # filter one position (defualt max_exclude_percentage, # non-defualt excludes) aln = LoadSeqs(data={'1':'WCDE','2':'ACDE','3':'ACDE','4':'ACDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[gDefaultNullValue]*4,[gDefaultNullValue,18.,5.,6.], [gDefaultNullValue,1.,3.,2.],[gDefaultNullValue,0.,1.,33.]]) filter_exclude_positions(aln,m,excludes='W') self.assertFloatEqual(m,expected) # filter one position (defualt max_exclude_percentage, # non-defualt null_value) aln = LoadSeqs(data={'1':'-CDE','2':'ACDE','3':'ACDE','4':'ACDE'},\ moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.], [4.,1.,3.,2.],[21.,0.,1.,33.]]) expected = array([[999.]*4,[999.,18.,5.,6.], [999.,1.,3.,2.],[999.,0.,1.,33.]]) filter_exclude_positions(aln,m,null_value=999.) self.assertFloatEqual(m,expected) def test_filter_exclude_positions_intermolecular(self): """filter_exclude_positions: functions for intermolecular data """ # these tests correspond to alignments of length 4 and 2 positions # respectively, hence a coevolution_matrix with shape = (2,4) # filter zero positions (no excludes) merged_aln = LoadSeqs(data={'1':'WCDEDE','2':'ACDEDE',\ '3':'ACDEDE','4':'ACDEDE'},moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) filter_exclude_positions(merged_aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) # filter one position (aln1) merged_aln = LoadSeqs(data={'1':'WC-EDE','2':'ACDEDE',\ '3':'ACDEDE','4':'ACDEDE'},moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[1.,10.,gDefaultNullValue,3.],\ [9.,18.,gDefaultNullValue,6.]]) filter_exclude_positions(merged_aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) # filter one position (aln2) merged_aln = LoadSeqs(data={'1':'WCEEDE','2':'ACDEDE',\ '3':'ACDEDE','4':'ACDED-'},moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[1.,10.,4.,3.],\ [gDefaultNullValue]*4]) filter_exclude_positions(merged_aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) # filter two positions (aln1 & aln2) merged_aln = LoadSeqs(data={'1':'-CEEDE','2':'ACDEDE',\ '3':'ACDEDE','4':'ACDED-'},moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[gDefaultNullValue,10.,4.,3.],\ [gDefaultNullValue]*4]) filter_exclude_positions(merged_aln,m,intermolecular_data_only=True) self.assertFloatEqual(m,expected) # filter two positions (aln1 & aln2, alt excludes) merged_aln = LoadSeqs(data={'1':'WCEEDE','2':'ACDEDE',\ '3':'ACDEDE','4':'ACDEDW'},moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[gDefaultNullValue,10.,4.,3.],\ [gDefaultNullValue]*4]) filter_exclude_positions(merged_aln,m,intermolecular_data_only=True,\ excludes='W') self.assertFloatEqual(m,expected) # filter two positions (aln1 & aln2, alt null_value) merged_aln = LoadSeqs(data={'1':'-CEEDE','2':'ACDEDE',\ '3':'ACDEDE','4':'ACDED-'},moltype=PROTEIN,aligned=DenseAlignment) m = array([[1.,10.,4.,3.],[9.,18.,5.,6.]]) expected = array([[999.,10.,4.,3.],\ [999.]*4]) filter_exclude_positions(merged_aln,m,intermolecular_data_only=True,\ null_value=999.) self.assertFloatEqual(m,expected) def test_filter_threshold_based_multiple_interdependency_intermolecular(self): "multiple interdependency filter functions with intermolecular data " ## cmp_function = ge # lower boundary null = gDefaultNullValue m = array([[0.63,0.00,null],\ [0.75,0.10,0.45],\ [0.95,0.32,0.33],\ [1.00,0.95,0.11]]) expected = array([[null,null,null],\ [null,null,0.45],\ [null,null,null],\ [null,null,null]]) actual = filter_threshold_based_multiple_interdependency(\ None,m,0.95,0,greater_equal,True) self.assertFloatEqual(actual,expected) # realisitic test case m = array([[0.63,0.00,null],\ [0.75,0.10,0.45],\ [0.95,0.32,0.33],\ [1.00,0.95,0.11]]) expected = array([[null,0.00,null],\ [null,0.10,0.45],\ [null,0.32,0.33],\ [null,null,null]]) actual = filter_threshold_based_multiple_interdependency(\ None,m,0.95,1,greater_equal,True) self.assertFloatEqual(actual,expected) # upper boundary, nothing filtered null = gDefaultNullValue m = array([[0.63,0.00,null],\ [0.75,0.10,0.45],\ [0.95,0.32,0.33],\ [1.00,0.95,0.11]]) expected = m actual = filter_threshold_based_multiple_interdependency(\ None,m,0.95,5,greater_equal,True) self.assertFloatEqual(actual,expected) # cmp_function = less_equal, realistic test case m = array([[0.63,0.00,null],\ [0.75,0.10,0.45],\ [0.95,0.32,0.33],\ [1.00,0.95,0.11]]) expected = array([[0.63,null,null],\ [0.75,null,null],\ [null,null,null],\ [1.00,null,null]]) actual = filter_threshold_based_multiple_interdependency(\ None,m,0.35,1,less_equal,True) self.assertFloatEqual(actual,expected) def test_filter_threshold_based_multiple_interdependency_intramolecular(self): "multiple interdependency filter functions with intramolecular data " null = gDefaultNullValue ## cmp_function = ge # lower bound, everything filtered m = array([[0.63,0.75,0.95,1.00],\ [0.75,0.10,null,0.95],\ [0.95,null,0.33,0.11],\ [1.00,0.95,0.11,1.00]]) expected = array([[null,null,null,null],\ [null,null,null,null],\ [null,null,null,null],\ [null,null,null,null]]) actual = filter_threshold_based_multiple_interdependency(\ None,m,0.95,0,greater_equal) self.assertFloatEqual(actual,expected) # realistic test case m = array([[0.63,0.75,0.95,1.00],\ [0.75,0.10,null,0.95],\ [0.95,null,0.33,0.11],\ [1.00,0.95,0.11,1.00]]) expected = array([[null,null,null,null],\ [null,0.10,null,null],\ [null,null,0.33,null],\ [null,null,null,null]]) actual = filter_threshold_based_multiple_interdependency(\ None,m,0.95,1,greater_equal) self.assertFloatEqual(actual,expected) # upper boundary, nothing filtered m = array([[0.63,0.75,0.95,1.00],\ [0.75,0.10,null,0.95],\ [0.95,null,0.33,0.11],\ [1.00,0.95,0.11,1.00]]) expected = m actual = filter_threshold_based_multiple_interdependency(\ None,m,0.95,5,greater_equal) self.assertFloatEqual(actual,expected) ## cmp_function = le # realistic test case m = array([[0.63,0.75,0.95,1.00],\ [0.75,0.10,null,0.95],\ [0.95,null,0.33,0.11],\ [1.00,0.95,0.11,1.00]]) expected = array([[0.63,0.75,null,1.00],\ [0.75,0.10,null,0.95],\ [null,null,null,null],\ [1.00,0.95,null,1.00]]) actual = filter_threshold_based_multiple_interdependency(\ None,m,0.33,1,less_equal) self.assertFloatEqual(actual,expected) def test_probs_from_dict(self): """probs_from_dict: dict of probs -> list of probs in alphabet's order """ d = {'A':0.25,'D':0.52,'C':0.23} a = list('ACD') self.assertFloatEqual(probs_from_dict(d,a),[0.25,0.23,0.52]) a = list('ADC') self.assertFloatEqual(probs_from_dict(d,a),[0.25,0.52,0.23]) a = list('DCA') self.assertFloatEqual(probs_from_dict(d,a),[0.52,0.23,0.25]) a = CharAlphabet('DCA') self.assertFloatEqual(probs_from_dict(d,a),[0.52,0.23,0.25]) # protein natural probs l = probs_from_dict(protein_dict,AAGapless) for i in range(20): self.assertFloatEqual(l[i],protein_dict[AAGapless[i]],0.001) def test_freqs_from_aln(self): """freqs_from_aln: freqs of alphabet chars in aln is calc'ed correctly """ # non-default scaled_aln_size aln = DenseAlignment(data=zip(range(4),['ACGT','AGCT','ACCC','TAGG']),\ MolType=PROTEIN) alphabet = 'ACGT' expected = [4,5,4,3] self.assertEqual(freqs_from_aln(aln,alphabet,16),expected) # change the order of the alphabet alphabet = 'TGCA' expected = [3,4,5,4] self.assertEqual(freqs_from_aln(aln,alphabet,16),expected) # default scaled_aln_size, sums of freqs == 100 alphabet = 'ACGT' expected = [25.,31.25,25,18.75] self.assertEqual(freqs_from_aln(aln,alphabet),expected) # alphabet char which doesn't show up gets zero freq alphabet = 'ACGTW' expected = [25.,31.25,25,18.75,0] self.assertEqual(freqs_from_aln(aln,alphabet),expected) # alignment char which doesn't show up is silently ignored aln = DenseAlignment(data=zip(range(4),['ACGT','AGCT','ACCC','TWGG']),\ MolType=PROTEIN) alphabet = 'ACGT' expected = [18.75,31.25,25,18.75] self.assertEqual(freqs_from_aln(aln,alphabet),expected) def test_freqs_to_array(self): """freqs_to_array: should convert Freqs object to array""" #should work with empty object f = Freqs() f2a = freqs_to_array self.assertFloatEqual(f2a(f, AAGapless), zeros(20)) #should work with full object, omitting unwanted keys f = Freqs({'A':20, 'Q':30, 'X':20}) expected = zeros(20) expected[AAGapless.index('A')] = 20 expected[AAGapless.index('Q')] = 30 self.assertFloatEqual(expected, f2a(f, AAGapless)) #should work for normal dict and any alphabet d = {'A':3,'D':1,'C':5,'E':2} alpha = "ABCD" exp = array([3,0,5,1]) self.assertFloatEqual(f2a(d,alpha),exp) def test_get_allowed_perturbations(self): """get_allowed_perturbations: should work for different cutoff values """ counts = [50,40,10,0] a = list('ACGT') self.assertEqual(get_allowed_perturbations(counts,1.0,a),[]) self.assertEqual(get_allowed_perturbations(counts,0.51,a),[]) self.assertEqual(get_allowed_perturbations(counts,0.5,a),['A']) self.assertEqual(get_allowed_perturbations(counts,0.49,a),['A']) self.assertEqual(get_allowed_perturbations(counts,0.401,a),['A']) self.assertEqual(get_allowed_perturbations(counts,0.40,a),['A','C']) self.assertEqual(get_allowed_perturbations(counts,0.399,a),['A','C']) self.assertEqual(get_allowed_perturbations(counts,0.10,a),\ ['A','C','G']) self.assertEqual(get_allowed_perturbations(counts,0.0,a),a) def test_get_subalignments(self): """get_subalignments: works with different alignment sizes and cutoffs """ aln = DenseAlignment(\ data={1:'AAAA',2:'AAAC',3:'AACG',4:'ACCT',5:'ACG-'},\ MolType=PROTEIN) sub_aln_0A = DenseAlignment(\ data={1:'AAAA',2:'AAAC',3:'AACG',4:'ACCT',5:'ACG-'},\ MolType=PROTEIN) sub_aln_0C = {} sub_aln_1A = DenseAlignment(data={1:'AAAA',2:'AAAC',3:'AACG'},\ MolType=PROTEIN) sub_aln_1C = DenseAlignment(data={4:'ACCT',5:'ACG-'},MolType=PROTEIN) sub_aln_2G = DenseAlignment(data={5:'ACG-'},MolType=PROTEIN) self.assertEqual(get_subalignments(aln,0,['A']),[sub_aln_0A]) self.assertEqual(get_subalignments(aln,0,['C']),[sub_aln_0C]) self.assertEqual(get_subalignments(aln,1,['A']),[sub_aln_1A]) self.assertEqual(get_subalignments(aln,1,['C']),[sub_aln_1C]) self.assertEqual(get_subalignments(aln,1,['A','C']),\ [sub_aln_1A,sub_aln_1C]) self.assertEqual(get_subalignments(aln,2,['G']),[sub_aln_2G]) self.assertEqual(get_subalignments(aln,3,['-']),[sub_aln_2G]) def test_get_positional_frequencies_w_scale(self): """get_positional_frequencies: works with default scaled_aln_size""" aln = DenseAlignment(data={1:'ACDE',2:'ADDE',3:'AEED',4:'AFEF'},\ MolType=PROTEIN) expected_0 = array([100.,0.,0.,0.,0.]) expected_1 = array([0.,25.,25.,25.,25.]) expected_2 = array([0.,0.,50.,50.,0.]) expected_3 = array([0.,0.,25.,50.,25.]) self.assertFloatEqual(get_positional_frequencies(aln,0,'ACDEF'),expected_0) self.assertFloatEqual(get_positional_frequencies(aln,1,'ACDEF'),expected_1) self.assertFloatEqual(get_positional_frequencies(aln,2,'ACDEF'),expected_2) self.assertFloatEqual(get_positional_frequencies(aln,3,'ACDEF'),expected_3) # extra characters (W) are silently ignored -- is this the desired # behavior? aln = DenseAlignment(data={1:'WCDE',2:'ADDE',3:'AEED',4:'AFEF'},\ MolType=PROTEIN) expected_0 = array([75.,0.,0.,0.,0.]) self.assertFloatEqual(get_positional_frequencies(aln,0,'ACDEF'),expected_0) # 20 residue amino acid alphabet aln = DenseAlignment(data={1:'ACDE',2:'ADDE',3:'AEED',4:'AFEF'},\ MolType=PROTEIN) expected = array([100.] + [0.]*19) self.assertFloatEqual(get_positional_frequencies(aln,0,AAGapless),expected) def test_get_positional_frequencies(self): """get_positional_frequencies: works with non-default scaled_aln_size """ aln = DenseAlignment(data={1:'ACDE',2:'ADDE',3:'AEED',4:'AFEF'},\ MolType=PROTEIN) expected_0 = array([4.,0.,0.,0.,0.]) expected_1 = array([0.,1.,1.,1.,1.]) expected_2 = array([0.,0.,2.,2.,0.]) expected_3 = array([0.,0.,1.,2.,1.]) self.assertFloatEqual(get_positional_frequencies(aln,0,'ACDEF',4),\ expected_0) self.assertFloatEqual(get_positional_frequencies(aln,1,'ACDEF',4),\ expected_1) self.assertFloatEqual(get_positional_frequencies(aln,2,'ACDEF',4),\ expected_2) self.assertFloatEqual(get_positional_frequencies(aln,3,'ACDEF',4),\ expected_3) # extra characters (W) are silently ignored -- is this the desired # behavior? aln = DenseAlignment(data={1:'WCDE',2:'ADDE',3:'AEED',4:'AFEF'},\ MolType=PROTEIN) expected_0 = array([3.,0.,0.,0.,0.]) self.assertFloatEqual(get_positional_frequencies(aln,0,'ACDEF',4),\ expected_0) # 20 residue amino acid alphabet aln = DenseAlignment(data={1:'ACDE',2:'ADDE',3:'AEED',4:'AFEF'},\ MolType=PROTEIN) expected = array([4.] + [0.]*19) self.assertFloatEqual(get_positional_frequencies(aln,0,AAGapless,4),\ expected) def test_validate_alphabet_invalid(self): """validate_alphabet: raises error on incompatible alpabet and freqs """ # len(alpha) > len(freqs) self.assertRaises(ValueError,validate_alphabet,\ 'ABC',{'A':0.5,'B':0.5}) self.assertRaises(ValueError,validate_alphabet,\ 'ABCD',{'A':0.5,'B':0.5}) # len(alpha) == len(freqs) self.assertRaises(ValueError,validate_alphabet,\ 'AC',{'A':0.5,'B':0.5}) # len(alpha) < len(freqs) self.assertRaises(ValueError,validate_alphabet,\ 'A',{'A':0.5,'B':0.5}) self.assertRaises(ValueError,validate_alphabet,'',\ {'A':0.5,'B':0.5}) # different values, len(alpha) > len(freqs) self.assertRaises(ValueError,validate_alphabet,[1,42,3],\ {42:0.5,1:0.5}) self.assertRaises(ValueError,validate_alphabet,CharAlphabet('ABC'),\ {'A':0.5,'C':0.5}) def test_validate_alphabet_valid(self): """validate_alphabet: does nothing on compatible alpabet and freqs """ validate_alphabet('AB',{'A':0.5,'B':0.5}) validate_alphabet(CharAlphabet('AB'),{'A':0.5,'B':0.5}) validate_alphabet([1,42,8],{1:0.5,42:0.25,8:0.25}) def test_validate_position_invalid(self): """validate_position: raises error on invalid position """ self.assertRaises(ValueError,validate_position,self.dna_aln,4) self.assertRaises(ValueError,validate_position,self.dna_aln,42) self.assertRaises(ValueError,validate_position,self.dna_aln,-1) self.assertRaises(ValueError,validate_position,self.dna_aln,-199) def test_validate_position_valid(self): """validate_position: does nothing on valid position """ validate_position(self.dna_aln,0) validate_position(self.dna_aln,1) validate_position(self.dna_aln,2) validate_position(self.dna_aln,3) def test_validate_alignment(self): """validate_alignment: ValueError on bad alignment characters""" # ambiguous characters aln = DenseAlignment(data={0:'BA',1:'AC',2:'CG',3:'CT',4:'TA'},\ MolType=PROTEIN) self.assertRaises(ValueError,validate_alignment,aln) aln = DenseAlignment(data={0:'NA',1:'AC',2:'CG',3:'CT',4:'TA'},\ MolType=DNA) self.assertRaises(ValueError,validate_alignment,aln) aln = DenseAlignment(data={0:'YA',1:'AC',2:'CG',3:'CU',4:'UA'},\ MolType=RNA) self.assertRaises(ValueError,validate_alignment,aln) aln = DenseAlignment(data={0:'AA',1:'AC',2:'CG',3:'CT',4:'TA'},\ MolType=PROTEIN) validate_alignment(aln) aln = DenseAlignment(data={0:'AA',1:'AC',2:'CG',3:'CT',4:'TA'},\ MolType=DNA) validate_alignment(aln) aln = DenseAlignment(data={0:'AA',1:'AC',2:'CG',3:'CU',4:'UA'},\ MolType=RNA) validate_alignment(aln) def test_coevolve_functions_validate_alignment(self): """coevolve_*: functions run validate alignment""" aln = DenseAlignment(\ data={'0':'BA','1':'AC','2':'CG','3':'CT','4':'TA'},\ MolType=PROTEIN) self.assertRaises(ValueError,coevolve_pair,mi_pair,aln,0,1) self.assertRaises(ValueError,coevolve_position,mi_position,aln,0) self.assertRaises(ValueError,coevolve_alignment,mi_alignment,aln) self.assertRaises(ValueError,coevolve_alignments,mi_alignment,aln,aln) def test_get_positional_probabilities_w_non_def_num_seqs(self): """get_positional_probabilities: works w/ non-def num_seqs""" freqs = [1.,2.,0.] probs = [0.33,0.33,0.33] expected = array([0.444411,0.218889,0.300763]) self.assertFloatEqual(get_positional_probabilities(freqs,probs,3),\ expected) def test_get_dg(self): """get_dg: returns delta_g vector""" p = [0.1,0.2,0.3] a = [0.5,0.6,0.7] expected = [log(0.1/0.5),log(0.2/0.6),log(0.3/0.7)] self.assertFloatEqual(get_dg(p,a),expected) def test_get_dgg(self): """get_dgg: returns delta_delta_g value given two delta_g vectors """ v1 = array([0.05,0.5,0.1]) v2 = array([0.03,0.05,0.1]) expected = sqrt(sum((v1 - v2) * (v1 - v2)))/100 * e self.assertFloatEqual(get_dgg(v1,v2),expected) def test_get_positional_probabilities_w_def_num_seqs(self): """get_positional_probabilities: works w/ num_seqs scaled to 100 (def) """ freqs = [15.,33.,52.] probs = [0.33,0.33,0.33] expected = array([2.4990e-5,0.0846,3.8350e-5]) self.assertFloatEqual(get_positional_probabilities(freqs,probs),\ expected,0.001) def test_get_positional_probs_handles_rounding_error_in_freqs(self): """get_positional_probabilities: works w/ rounding error in freqs""" # Since freqs are scaled to scaled_aln_size, rounding error can cause # errors for positions that are perfectly controled. Testing here that # that value error is handled. # default scaled_aln_size freqs = [100.0000000001,0.,0.] probs = [0.33,0.33,0.33] expected = array([7.102218e-49,4.05024e-18,4.05024e-18]) self.assertFloatEqual(get_positional_probabilities(freqs,probs),\ expected) # value that is truely over raises an error freqs = [101.0000000001,0.,0.] probs = [0.33,0.33,0.33] self.assertRaises(ValueError,get_positional_probabilities,freqs,probs) # non-default scaled_aln_size freqs = [50.0000000001,0.,0.] probs = [0.33,0.33,0.33] expected = array([8.42747e-25,2.01252e-9,2.01252e-9]) self.assertFloatEqual(get_positional_probabilities(freqs,probs,50),\ expected) # value that is truely over raises an error freqs = [51.0000000001,0.,0.] probs = [0.33,0.33,0.33] self.assertRaises(ValueError,get_positional_probabilities,\ freqs,probs,50) def test_sca_input_validation(self): """sca_input_validation: handles sca-specific validation steps """ # MolType != PROTEIN makes background freqs required self.assertRaises(ValueError,sca_input_validation,\ self.dna_aln,cutoff=0.4) self.assertRaises(ValueError,sca_input_validation,\ self.rna_aln,cutoff=0.4) # no cutoff -> ValueError self.assertRaises(ValueError,sca_input_validation,self.protein_aln) # low cutoff -> ValueError self.assertRaises(ValueError,sca_input_validation,\ self.protein_aln,cutoff=-0.001) # high cutoff -> ValueError self.assertRaises(ValueError,sca_input_validation,\ self.protein_aln,cutoff=1.001) # good cut-off -> no error sca_input_validation(self.protein_aln,cutoff=0.50) sca_input_validation(self.protein_aln,cutoff=0.0) sca_input_validation(self.protein_aln,cutoff=1.0) # only bad alphabet -> ValueError self.assertRaises(ValueError,sca_input_validation,\ self.dna_aln,cutoff=0.5,alphabet='ABC') # only bad background_freqs -> ValueError self.assertRaises(ValueError,sca_input_validation,\ self.dna_aln,cutoff=0.5, background_freqs={'A':0.25, 'C':0.75}) # incompatible background_freqs & alphabet provided -> ValueError self.assertRaises(ValueError,sca_input_validation,\ self.dna_aln,cutoff=0.5, alphabet='ABC', \ background_freqs={'A':0.25, 'C':0.75}) # default alphabet, background_freqs -> no error sca_input_validation(self.protein_aln,cutoff=0.50) # compatible non-default alphabet, backgorund_freqs -> no error sca_input_validation(self.dna_aln,cutoff=0.50,alphabet='A',\ background_freqs={'A':1.0}) ## Note: don't need a full set of tests of validate_alphabet here -- ## it's tested on it's own. def test_sca_pair_no_error(self): """sca_pair: returns w/o error """ r = sca_pair(self.dna_aln,1,0,cutoff=0.50,alphabet='ACGT',\ background_freqs=self.dna_base_freqs) r = coevolve_pair(sca_pair,self.dna_aln,1,0,cutoff=0.50,\ alphabet='ACGT',background_freqs=self.dna_base_freqs) def test_sca_pair_return_all(self): """sca_pair: handles return_all by returning lists of proper length """ # two allowed_perturbations a = 'ACGT' aln = DenseAlignment(data={0:'AA',1:'AC',2:'CG',3:'CT',4:'TA'},\ MolType=DNA) actual = sca_pair(aln,0,1,cutoff=0.33,return_all=True,alphabet=a,\ background_freqs=self.dna_base_freqs) self.assertEqual(len(actual),2) self.assertEqual(actual[0][0], 'A') self.assertEqual(actual[1][0], 'C') # one allowed_perturbations a = 'ACGT' aln = DenseAlignment(data={0:'AA',1:'AC',2:'AG',3:'CT',4:'TA'},\ MolType=DNA) actual = sca_pair(aln,0,1,0.33,return_all=True,alphabet=a,\ background_freqs=self.dna_base_freqs) self.assertEqual(len(actual),1) self.assertEqual(actual[0][0], 'A') # zero allowed_perturbations actual = sca_pair(aln,0,1,1.0,return_all=True,alphabet=a,\ background_freqs=self.dna_base_freqs) #expected = [('A',-1),('C',-1)] expected = gDefaultNullValue self.assertFloatEqual(actual,expected) # pos1 == pos2 actual = sca_pair(aln,0,0,0.33,return_all=True,alphabet=a,\ background_freqs=self.dna_base_freqs) #expected = [('A',-1),('C',-1)] expected = [('A', 2.40381185618)] self.assertFloatEqual(actual,expected) def test_sca_pair_error(self): """sca_pair:returns w/ error when appropriate """ a = 'ACGT' # pos1 out of range self.assertRaises(ValueError,coevolve_pair,sca_pair,self.dna_aln,\ 100,1,cutoff=0.50,alphabet=a,background_freqs=self.dna_base_freqs) # pos2 out of range self.assertRaises(ValueError,coevolve_pair,sca_pair,self.dna_aln,\ 0,100,cutoff=0.50,alphabet=a,background_freqs=self.dna_base_freqs) # pos1 & pos2 out of range self.assertRaises(ValueError,coevolve_pair,sca_pair,self.dna_aln,\ 100,100,cutoff=0.50,alphabet=a,\ background_freqs=self.dna_base_freqs) # bad cut-off self.assertRaises(ValueError,coevolve_pair,sca_pair,\ self.dna_aln,0,1,cutoff=1.2,\ alphabet=a,background_freqs=self.dna_base_freqs) # incompatible alphabet and background freqs self.assertRaises(ValueError,coevolve_pair,sca_pair,\ self.dna_aln,0,1,cutoff=0.2,alphabet=a) self.assertRaises(ValueError,coevolve_pair,sca_pair,\ self.dna_aln,0,1,cutoff=0.2,alphabet='ACGTBC',\ background_freqs=self.dna_base_freqs) def test_sca_position_no_error(self): """sca_position: returns w/o error """ r = sca_position(self.dna_aln,1,0.50,alphabet='ACGT',\ background_freqs=self.dna_base_freqs) # sanity check -- coupling w/ self self.assertFloatEqual(r[1],3.087,0.01) r = sca_position(self.dna_aln_gapped,1,0.50,\ alphabet='ACGT',background_freqs=self.dna_base_freqs) self.assertFloatEqual(r[1],3.387,0.01) ## same tests, but called via coevolve_position r = coevolve_position(sca_position,self.dna_aln,1,cutoff=0.50,\ alphabet='ACGT',background_freqs=self.dna_base_freqs) # sanity check -- coupling w/ self self.assertFloatEqual(r[1],3.087,0.01) r = coevolve_position(sca_position,self.dna_aln_gapped,1,cutoff=0.50,\ alphabet='ACGT',background_freqs=self.dna_base_freqs) # sanity check -- coupling w/ self self.assertFloatEqual(r[1],3.387,0.01) def test_sca_position_error(self): """sca_position: returns w/ error when appropriate """ a = 'ACGT' # position out of range self.assertRaises(ValueError,coevolve_position,sca_position,\ self.dna_aln,100,cutoff=0.50,alphabet=a,\ background_freqs=self.dna_base_freqs) # bad cutoff self.assertRaises(\ ValueError,coevolve_position,sca_position,self.dna_aln,\ 1,cutoff=-8.2,alphabet=a,background_freqs=self.dna_base_freqs) # incompatible alphabet and background freqs self.assertRaises(ValueError,coevolve_position,sca_position,\ self.dna_aln,0,cutoff=0.2,alphabet=a) self.assertRaises(ValueError,coevolve_position,sca_position,\ self.dna_aln,0,cutoff=0.2,alphabet='ACGTBC',\ background_freqs=self.dna_base_freqs) def test_sca_position_returns_same_as_sca_pair(self): """sca_position: returns same as sca_pair called on each pos """ expected = [] for i in range(len(self.dna_aln)): expected.append(sca_pair(self.dna_aln,1,i,0.50,\ alphabet='ACGT',background_freqs=self.dna_base_freqs)) actual = sca_position(self.dna_aln,1,0.50,\ alphabet='ACGT',background_freqs=self.dna_base_freqs) self.assertFloatEqual(actual,expected) # change some of the defaults to make sure they make it through bg_freqs = {'A':0.50,'C':0.50} expected = [] for i in range(len(self.dna_aln)): expected.append(sca_pair(self.dna_aln,1,i,0.50,\ alphabet='AC',null_value=52.,scaled_aln_size=20,\ background_freqs=bg_freqs)) actual = sca_position(self.dna_aln,1,0.50,alphabet='AC',\ null_value=52.,scaled_aln_size=20,background_freqs=bg_freqs) self.assertFloatEqual(actual,expected) def test_sca_alignment_no_error(self): """sca_alignment: returns w/o error """ r = sca_alignment(self.dna_aln,0.50,alphabet='ACGT',\ background_freqs=self.dna_base_freqs) # sanity check -- coupling w/ self self.assertFloatEqual(r[0][0],2.32222608171) ## same test, but called via coevolve_alignment r = coevolve_alignment(sca_alignment,self.dna_aln,\ cutoff=0.50,alphabet='ACGT',\ background_freqs=self.dna_base_freqs) # sanity check -- coupling w/ self self.assertFloatEqual(r[0][0],2.32222608171) def test_sca_alignment_error(self): """sca_alignment: returns w/ error when appropriate """ a = 'ACGT' # incompatible alphabet and background freqs self.assertRaises(ValueError,coevolve_position,sca_position,\ self.dna_aln,0,cutoff=0.2,alphabet=a) self.assertRaises(ValueError,coevolve_position,sca_position,\ self.dna_aln,0,cutoff=0.2,alphabet='ACGTBC',\ background_freqs=self.dna_base_freqs) def test_sca_alignment_returns_same_as_sca_position(self): """sca_alignment: returns same as sca_position on every position""" expected = [] for i in range(len(self.dna_aln)): expected.append(\ sca_position(self.dna_aln,i,0.50,alphabet='ACGT',\ background_freqs=self.dna_base_freqs)) actual = sca_alignment(self.dna_aln,0.50,alphabet='ACGT',\ background_freqs=self.dna_base_freqs) self.assertFloatEqual(actual,expected) # change some of the defaults to make sure they make it through bg_freqs = {'A':0.50,'C':0.50} expected = [] for i in range(len(self.dna_aln)): expected.append(\ sca_position(self.dna_aln,i,0.50,alphabet='AC',\ null_value=52.0,scaled_aln_size=20,background_freqs=bg_freqs)) actual = sca_alignment(self.dna_aln,0.50,alphabet='AC',\ null_value=52.0,scaled_aln_size=20,background_freqs=bg_freqs) self.assertFloatEqual(actual,expected) def test_sca_pair_gpcr(self): """sca_pair: reproduces several GPCR data from Suel et al., 2003 """ self.assertFloatEqual(sca_pair(self.gpcr_aln,295,18,0.32),0.12,0.1) self.assertFloatEqual(sca_pair(self.gpcr_aln,295,124,0.32),1.86,0.1) self.assertFloatEqual(sca_pair(self.gpcr_aln,295,304,0.32),0.3,0.1) # covariation w/ self self.assertFloatEqual(sca_pair(self.gpcr_aln,295,295,0.32),7.70358628) def test_sca_position_gpcr(self): """sca_position: reproduces several GPCR data from Suel et al., 2003 """ if not self.run_slow_tests: return vector = sca_position(self.gpcr_aln,295,0.32) self.assertFloatEqual(vector[18],0.12,0.1) self.assertFloatEqual(vector[124],1.86,0.1) self.assertFloatEqual(vector[304],0.3,0.1) # covariation w/ self == null_value self.assertFloatEqual(vector[295],nan) def test_ltm_to_symmetric(self): """ltm_to_symmetric: making ltm matrices symmetric functions""" m = arange(9).reshape((3,3)) expected = [[0,3,6],[3,4,7],[6,7,8]] self.assertEqual(ltm_to_symmetric(m),expected) # non-square matrices not supported self.assertRaises(AssertionError,\ ltm_to_symmetric,arange(10).reshape(5,2)) self.assertRaises(AssertionError,\ ltm_to_symmetric,arange(10).reshape(2,5)) def test_merge_alignments(self): """ merging alignments of same moltype functions as expected""" # PROTEIN aln1 = DenseAlignment(data={'1':'AC','2':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1':'EF','2':'EG'},MolType=PROTEIN) combined_aln = DenseAlignment(\ data={'1':'ACEF','2':'ADEG'},MolType=PROTEIN) actual = merge_alignments(aln1,aln2) self.assertEqual(actual,combined_aln) self.assertEqual(actual.MolType,PROTEIN) # RNA aln1 = DenseAlignment(data={'1':'AC','2':'AU'},MolType=RNA) aln2 = DenseAlignment(data={'1':'GG','2':'UG'},MolType=RNA) combined_aln = DenseAlignment(data={'1':'ACGG','2':'AUUG'},MolType=RNA) actual = merge_alignments(aln1,aln2) self.assertEqual(actual,combined_aln) self.assertEqual(actual.MolType,RNA) # DNA aln1 = DenseAlignment(data={'1':'AC','2':'AT'},MolType=DNA) aln2 = DenseAlignment(data={'1':'GG','2':'TG'},MolType=DNA) combined_aln = DenseAlignment(data={'1':'ACGG','2':'ATTG'},MolType=DNA) actual = merge_alignments(aln1,aln2) self.assertEqual(actual,combined_aln) self.assertEqual(actual.MolType,DNA) def test_merge_alignments_ignores_id_following_plus(self): """ merge_alignments ignores all seq id characters after '+' """ aln1 = DenseAlignment(data={'1+a':'AC','2+b':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(\ data={'1 + c':'EFW','2 + d':'EGY'},MolType=PROTEIN) combined_aln = DenseAlignment(\ data={'1':'ACEFW','2':'ADEGY'},MolType=PROTEIN) self.assertEqual(merge_alignments(aln1,aln2),combined_aln) # not all ids have a + aln1 = DenseAlignment(data={'1':'AC','2+b':'AD'},MolType=PROTEIN) aln2 = DenseAlignment(data={'1+c':'EFW','2':'EGY'},MolType=PROTEIN) combined_aln = DenseAlignment(\ data={'1':'ACEFW','2':'ADEGY'},MolType=PROTEIN) self.assertEqual(merge_alignments(aln1,aln2),combined_aln) def test_merge_alignments_different_moltype(self): """ merging alignments of different moltype functions as expected""" aln1 = DenseAlignment(data={'1':'AC','2':'AU'},MolType=RNA) aln2 = DenseAlignment(data={'1':'EF','2':'EG'},MolType=PROTEIN) combined_aln = DenseAlignment(data={'1':'ACEF','2':'AUEG'}) self.assertEqual(merge_alignments(aln1,aln2),combined_aln) aln1 = DenseAlignment(data={'1':'AC','2':'AT'},MolType=DNA) aln2 = DenseAlignment(data={'1':'EF','2':'EG'},MolType=PROTEIN) combined_aln = DenseAlignment(data={'1':'ACEF','2':'ATEG'}) self.assertEqual(merge_alignments(aln1,aln2),combined_aln) aln1 = DenseAlignment(data={'1':'AC','2':'AT'},MolType=DNA) aln2 = DenseAlignment(data={'1':'UC','2':'UG'},MolType=RNA) combined_aln = DenseAlignment(data={'1':'ACUC','2':'ATUG'}) self.assertEqual(merge_alignments(aln1,aln2),combined_aln) def test_n_random_seqs(self): """n_random_seqs: functions as expected""" aln1 = LoadSeqs(data=zip(list('abcd'),['AA','AC','DD','GG']),\ moltype=PROTEIN,aligned=DenseAlignment) # Number of returned sequences correct self.assertEqual(n_random_seqs(aln1,1).getNumSeqs(),1) self.assertEqual(n_random_seqs(aln1,2).getNumSeqs(),2) self.assertEqual(n_random_seqs(aln1,3).getNumSeqs(),3) self.assertEqual(n_random_seqs(aln1,4).getNumSeqs(),4) # Sequences are correct new_aln = n_random_seqs(aln1,3) self.assertEqual(new_aln.getNumSeqs(),3) for n in new_aln.Names: self.assertEqual(new_aln.getSeq(n),aln1.getSeq(n)) # Objects are equal when all are requested self.assertEqual(n_random_seqs(aln1,4),aln1) # Objects are not equal when subset are requested self.assertNotEqual(n_random_seqs(aln1,3),aln1) # In 1000 iterations, we get at least one different alignment -- # this tests the random selection different = False new_aln = n_random_seqs(aln1,2) for i in range(1000): new_aln2 = n_random_seqs(aln1,2) if new_aln != new_aln2: different = True break self.assertTrue(different) class AncestorCoevolve(TestCase): """ Tests of the ancestral state method for detecting coevolution """ def setUp(self): """ """ # t1, ancestral_states1, and aln1_* are used to test that when # alternate seqs are used with the same tree and ancestral_states, # the results vary when appropriate self.t1 = LoadTree(treestring=\ '((A:0.5,B:0.5):0.5,(C:0.5,(D:0.5,E:0.5):0.5):0.5);') self.ancestral_states1 = DenseAlignment(data={'root':'AAA',\ 'edge.0':'AAA','edge.1':'AAA','edge.2':'AAA'},MolType=PROTEIN) self.ancestral_states1_w_gaps = DenseAlignment(data={'root':'AAA',\ 'edge.0':'AAA','edge.1':'A-A','edge.2':'AA-'},MolType=PROTEIN) # no correlated changes count self.aln1_1 = DenseAlignment(data={'A':'AAC','B':'AAD','C':'AAA',\ 'D':'AAE','E':'AFA'},MolType=PROTEIN) # 1 correlated change count self.aln1_2 = DenseAlignment(data={'A':'AAC','B':'AAD','C':'AAA',\ 'D':'AEE','E':'AFF'},MolType=PROTEIN) # 1 different correlated change count self.aln1_3 = DenseAlignment(data={'A':'AAC','B':'AAD','C':'AAA',\ 'D':'AGE','E':'AFH'},MolType=PROTEIN) # 3 correlated change counts self.aln1_4 = DenseAlignment(data={'A':'AAC','B':'AGD','C':'AAA',\ 'D':'AGE','E':'AFH'},MolType=PROTEIN) # 8 correlated change counts self.aln1_5 = DenseAlignment(data={'A':'YYC','B':'HGD','C':'AAA',\ 'D':'AGE','E':'AFH'},MolType=PROTEIN) self.aln1_w_gaps = DenseAlignment(data={'A':'AAC','B':'AAD','C':'AAA',\ 'D':'AG-','E':'A-H'},MolType=PROTEIN) # t2, ancestral_states2_*, and aln2 are used to test that when # alternate ancestral states are used with the same aln and tree, # the results vary when appropriate self.t2 = LoadTree(treestring='(A:0.5,B:0.5,C:0.5);') self.ancestral_states2_1 = DenseAlignment(data={'root':'AA'},\ MolType=PROTEIN) self.ancestral_states2_2 = DenseAlignment(data={'root':'CC'},\ MolType=PROTEIN) self.ancestral_states2_3 = DenseAlignment(data={'root':'EF'},\ MolType=PROTEIN) self.aln2 = DenseAlignment(data={'A':'AA','B':'CC','C':'CA'},\ MolType=PROTEIN) # t3_*, ancestral_states3, and aln3 are used to test that when # alternate trees are used with the same aln and ancestral_states, # the results vary when appropriate self.t3_1 = LoadTree(treestring='(A:0.5,(B:0.5,C:0.5):0.5);') self.t3_2 = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') self.ancestral_states3 = DenseAlignment(\ data={'root':'CC','edge.0':'AD'},MolType=PROTEIN) self.aln3 = DenseAlignment(data={'A':'AC','B':'CA','C':'CC'},\ MolType=PROTEIN) def test_validate_ancestral_seqs_invalid(self): """validate_ancestral_seqs: ValueError on incompatible anc. seqs & tree """ # edge missing aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC'},MolType=PROTEIN) self.assertRaises(ValueError,validate_ancestral_seqs,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);'),\ ancestral_seqs=DenseAlignment(data={'root':'AA'},MolType=PROTEIN)) # root missing self.assertRaises(ValueError,validate_ancestral_seqs,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);'),\ ancestral_seqs=DenseAlignment(data={'edge.0':'AA'},MolType=PROTEIN)) # correct numSeqs but wrong names self.assertRaises(ValueError,validate_ancestral_seqs,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);'),\ ancestral_seqs=DenseAlignment(data={'root':'AA','edge.1':'AA'},\ MolType=PROTEIN)) self.assertRaises(ValueError,validate_ancestral_seqs,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);'),\ ancestral_seqs=DenseAlignment(data={'r':'AA','edge.0':'AA'},\ MolType=PROTEIN)) self.assertRaises(ValueError,validate_ancestral_seqs,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);'),\ ancestral_seqs=DenseAlignment(data={'r':'AA','e':'AA'},\ MolType=PROTEIN)) # different tree: invalid aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC','D':'DD'},\ MolType=PROTEIN) self.assertRaises(ValueError,validate_ancestral_seqs,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);'),\ ancestral_seqs=DenseAlignment(\ data={'root':'AA','e':'AA','edge.1':'AA'},MolType=PROTEIN)) def test_validate_ancestral_seqs_valid(self): """validate_ancestral_seqs: does nothing on compatible anc. seqs & tree """ aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC'},MolType=PROTEIN) # valid data -> no error validate_ancestral_seqs(aln,tree=LoadTree(\ treestring='((A:0.5,B:0.5):0.5,C:0.5);'),\ ancestral_seqs=DenseAlignment(data={'root':'AA','edge.0':'AA'},\ MolType=PROTEIN)) # different tree: valid aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC','D':'DD'},\ MolType=PROTEIN) validate_ancestral_seqs(aln,tree=LoadTree(\ treestring='((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);'),\ ancestral_seqs=DenseAlignment(data=\ {'root':'AA','edge.0':'AA','edge.1':'AA'},MolType=PROTEIN)) def test_ancestral_states_input_validation(self): """ancestral_states_input_validation: all validation steps performed""" aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC','D':'DD'},\ MolType=PROTEIN) # incompatible tree and ancestral states (more thorough testing in # test_validate_ancestral_seqs) self.assertRaises(ValueError,ancestral_states_input_validation,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);'),\ ancestral_seqs=DenseAlignment(data={'root':'AA','e':'AA',\ 'edge.1':'AA'},MolType=PROTEIN)) # no tree provided self.assertRaises(ValueError,ancestral_states_input_validation,aln,\ ancestral_seqs=DenseAlignment(data={'root':'AA','e':'AA',\ 'edge.1':'AA'},MolType=PROTEIN)) # incompatible tree and alignment (more tests in test_validate_tree) aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC'},MolType=PROTEIN) self.assertRaises(ValueError,ancestral_states_input_validation,aln,\ tree=LoadTree(treestring='((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);')) def test_validate_tree_valid(self): """validate_tree: does nothing on compatible tree and aln """ t = LoadTree(treestring='((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);') aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC','D':'DD'},\ MolType=PROTEIN) validate_tree(aln,t) t = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') aln = DenseAlignment(\ data={'A':'AC','B':'CA','C':'CC'},MolType=PROTEIN) validate_tree(aln,t) def test_validate_tree_invalid(self): """validate_tree: raises ValueError on incompatible tree and aln """ # different scale tree and aln t = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC','D':'DD'},\ MolType=PROTEIN) self.assertRaises(ValueError,validate_tree,aln,t) t = LoadTree(treestring='((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);') aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC'},\ MolType=PROTEIN) self.assertRaises(ValueError,validate_tree,aln,t) # same scale tree and aln, but different names t = LoadTree(treestring='((A:0.5,B:0.5):0.5,(C:0.5,Dee:0.5):0.5);') aln = DenseAlignment(data={'A':'AC','B':'CA','C':'CC','D':'DD'},\ MolType=PROTEIN) self.assertRaises(ValueError,validate_tree,aln,t) def test_get_ancestral_seqs(self): """get_ancestral_seqs: returns valid collection of ancestral seqs """ t = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') aln = DenseAlignment(data={'A':'AA','B':'AA','C':'AC'},MolType=PROTEIN) expected = DenseAlignment(data={'root':'AA','edge.0':'AA'},\ MolType=PROTEIN) self.assertEqual(get_ancestral_seqs(aln,t, optimise=False),expected) t = LoadTree(treestring='(A:0.5,B:0.5,C:0.5);') aln = DenseAlignment(data={'A':'AA','B':'AA','C':'AC'},\ MolType=PROTEIN) expected = DenseAlignment(data={'root':'AA'},MolType=PROTEIN) self.assertEqual(get_ancestral_seqs(aln,t, optimise=False),expected) t = LoadTree(treestring='(((A1:0.5,A2:0.5):0.5,B:0.5):0.5,\ (C:0.5,D:0.5):0.5);') aln = DenseAlignment(data={'A1':'AD','A2':'AD','B':'AC',\ 'C':'AC','D':'AC'},MolType=PROTEIN) expected = DenseAlignment(data={'root':'AC','edge.0':'AD',\ 'edge.1':'AC','edge.2':'AC'},MolType=PROTEIN) self.assertEqual(get_ancestral_seqs(aln,t, optimise=False),expected) def test_get_ancestral_seqs_handles_gaps(self): """get_ancestral_seqs: handles gaps """ # Gaps handled OK t = LoadTree(treestring='(A:0.5,B:0.5,C:0.5);') aln = DenseAlignment(data={'A':'A-','B':'AA','C':'AA'},MolType=PROTEIN) expected = DenseAlignment(data={'root':'AA'},MolType=PROTEIN) self.assertEqual(get_ancestral_seqs(aln,t, optimise=False),expected) def test_get_ancestral_seqs_handles_ambiguous_residues(self): """get_ancestral_seqs: handles ambiguous residues """ # Non-canonical residues handled OK t = LoadTree(treestring='(A:0.5,B:0.5,C:0.5);') aln = DenseAlignment(data={'A':'AX','B':'Z-','C':'BC'},MolType=PROTEIN) actual = get_ancestral_seqs(aln,t, optimise=False) self.assertEqual(len(actual),2) self.assertEqual(actual.getNumSeqs(),1) def test_ancestral_state_alignment_handles_ancestral_state_calc(self): """ancestral_state_alignment: functions when calc'ing ancestral states """ t = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') aln = DenseAlignment(data={'A':'AA','B':'AA','C':'AC'},MolType=PROTEIN) self.assertEqual(ancestral_state_alignment(aln,t),[[0,0],[0,2]]) # non-bifurcating tree t = LoadTree(treestring='(A:0.5,B:0.5,C:0.5);') aln = DenseAlignment(data={'A':'AA','B':'AA','C':'AC'},MolType=PROTEIN) self.assertEqual(ancestral_state_alignment(aln,t),[[0,0],[0,2]]) def test_ancestral_state_position_handles_ancestral_state_calc(self): """ancestral_state_position: functions when calc'ing ancestral states """ t = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') aln = DenseAlignment(data={'A':'AA','B':'AA','C':'AC'},MolType=PROTEIN) self.assertEqual(ancestral_state_position(aln,t,0),[0,0]) self.assertEqual(ancestral_state_position(aln,t,1),[0,2]) def test_ancestral_state_pair_handles_ancestral_state_calc(self): """ancestral_state_position: functions when calc'ing ancestral states """ t = LoadTree(treestring='((A:0.5,B:0.5):0.5,C:0.5);') aln = DenseAlignment(data={'A':'AA','B':'AA','C':'AC'},MolType=PROTEIN) self.assertEqual(ancestral_state_pair(aln,t,0,0),0) self.assertEqual(ancestral_state_pair(aln,t,0,1),0) self.assertEqual(ancestral_state_pair(aln,t,1,1),2) self.assertEqual(ancestral_state_pair(aln,t,1,0),0) def test_ancestral_state_alignment_no_error_on_gap(self): """ancestral_state_alignment: return w/o error with gapped seqs """ ancestral_state_alignment(self.aln1_w_gaps,self.t1,\ self.ancestral_states1) ancestral_state_alignment(self.aln1_1,self.t1,\ self.ancestral_states1_w_gaps) def test_ancestral_state_methods_handle_bad_ancestor_aln(self): """ancestral state methods raise error on bad ancestor alignment """ # bad length and seq names self.assertRaises(ValueError,coevolve_alignment,\ ancestral_state_alignment,self.aln1_2,\ tree=self.t1,ancestral_seqs=self.ancestral_states2_1) self.assertRaises(ValueError,coevolve_position,\ ancestral_state_position,self.aln1_2,0,\ tree=self.t1,ancestral_seqs=self.ancestral_states2_1) self.assertRaises(ValueError,coevolve_pair,\ ancestral_state_pair,self.aln1_2,0,1,\ tree=self.t1,ancestral_seqs=self.ancestral_states2_1) # bad seq names self.assertRaises(ValueError,coevolve_alignment,\ ancestral_state_alignment,self.aln1_2,\ tree=self.t1,ancestral_seqs=self.aln1_2) self.assertRaises(ValueError,coevolve_position,\ ancestral_state_position,self.aln1_2,0,\ tree=self.t1,ancestral_seqs=self.aln1_2) self.assertRaises(ValueError,coevolve_pair,\ ancestral_state_pair,self.aln1_2,0,1,\ tree=self.t1,ancestral_seqs=self.aln1_2) # bad length a = DenseAlignment(data={'root':'AC','edge.0':'AD','edge.1':'AA',\ 'edge.2':'EE'}) self.assertRaises(ValueError,coevolve_alignment,\ ancestral_state_alignment,self.aln1_2,\ tree=self.t1,ancestral_seqs=a) self.assertRaises(ValueError,coevolve_position,\ ancestral_state_position,self.aln1_2,0,\ tree=self.t1,ancestral_seqs=a) self.assertRaises(ValueError,coevolve_pair,\ ancestral_state_pair,self.aln1_2,0,1,\ tree=self.t1,ancestral_seqs=a) def test_ancestral_states_methods_handle_bad_position_numbers(self): """coevolve_* w/ ancestral_states raise ValueError on bad position """ self.assertRaises(ValueError,coevolve_position,\ ancestral_state_position,self.aln1_2,\ 42,tree=self.t1,ancestral_states=self.ancestral_states2_1) self.assertRaises(ValueError,coevolve_pair,\ ancestral_state_pair,self.aln1_2,\ 0,42,tree=self.t1,ancestral_states=self.ancestral_states2_1) self.assertRaises(ValueError,coevolve_pair,\ ancestral_state_pair,self.aln1_2,\ 42,0,tree=self.t1,ancestral_states=self.ancestral_states2_1) def test_ancestral_state_alignment_non_bifurcating_tree(self): """ancestral_state_alignment: handles non-bifurcating tree correctly """ self.assertEqual(ancestral_state_alignment(self.aln2,\ self.t2,self.ancestral_states2_3),[[9,9],[9,9]]) def test_ancestral_state_alignment_bifurcating_tree(self): """ancestral_state_alignment: handles bifurcating tree correctly """ self.assertFloatEqual(ancestral_state_alignment(self.aln1_5,\ self.t1,self.ancestral_states1),\ [[5,5,5],[5,11.6,11.6],[5,11.6,11.6]]) def test_ancestral_state_alignment_ancestor_difference(self): """ancestral_state_alignment: different ancestor -> different result """ # ancestral_states2_1 self.assertEqual(ancestral_state_alignment(self.aln2,\ self.t2,self.ancestral_states2_1),[[5,2],[2,2]]) # ancestral_states2_2 self.assertEqual(ancestral_state_alignment(self.aln2,\ self.t2,self.ancestral_states2_2),[[2,2],[2,5]]) # ancestral_states2_3 self.assertEqual(ancestral_state_alignment(self.aln2,\ self.t2,self.ancestral_states2_3),[[9,9],[9,9]]) def test_ancestral_state_position_ancestor_difference(self): """ancestral_state_position: difference_ancestor -> different result """ # ancestral_states2_1 self.assertEqual(ancestral_state_position(self.aln2,\ self.t2,0,self.ancestral_states2_1),[5,2]) self.assertEqual(ancestral_state_position(self.aln2,\ self.t2,1,self.ancestral_states2_1),[2,2]) # ancestral_states2_2 self.assertEqual(ancestral_state_position(self.aln2,\ self.t2,0,self.ancestral_states2_2),[2,2]) self.assertEqual(ancestral_state_position(self.aln2,\ self.t2,1,self.ancestral_states2_2),[2,5]) # ancestral_states2_3 self.assertEqual(ancestral_state_position(self.aln2,\ self.t2,0,self.ancestral_states2_3),[9,9]) self.assertEqual(ancestral_state_position(self.aln2,\ self.t2,1,self.ancestral_states2_3),[9,9]) def test_ancestral_state_pair_ancestor_difference(self): """ancestral_state_pair: difference_ancestor -> different result """ # ancestral_states2_1 self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,0,0,self.ancestral_states2_1),5) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,0,1,self.ancestral_states2_1),2) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,1,1,self.ancestral_states2_1),2) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,1,0,self.ancestral_states2_1),2) # ancestral_states2_2 self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,0,0,self.ancestral_states2_2),2) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,0,1,self.ancestral_states2_2),2) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,1,1,self.ancestral_states2_2),5) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,1,0,self.ancestral_states2_2),2) # ancestral_states2_3 self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,0,0,self.ancestral_states2_3),9) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,0,1,self.ancestral_states2_3),9) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,1,1,self.ancestral_states2_3),9) self.assertEqual(ancestral_state_pair(self.aln2,\ self.t2,1,0,self.ancestral_states2_3),9) def test_ancestral_state_alignment_tree_difference(self): """ancestral_state_alignment: different result on different tree """ # tree: t3_1 self.assertEqual(ancestral_state_alignment(self.aln3,\ self.t3_1,self.ancestral_states3),[[7,5],[5,5]]) # tree: t3_2 self.assertEqual(ancestral_state_alignment(self.aln3,\ self.t3_2,self.ancestral_states3),[[2,2],[2,5]]) def test_ancestral_state_position_tree_difference(self): """ancestral_state_position: different result on different tree """ # tree: t3_1 self.assertEqual(ancestral_state_position(self.aln3,\ self.t3_1,0,self.ancestral_states3),[7,5]) self.assertEqual(ancestral_state_position(self.aln3,\ self.t3_1,1,self.ancestral_states3),[5,5]) # tree: t3_2 self.assertEqual(ancestral_state_position(self.aln3,\ self.t3_2,0,self.ancestral_states3),[2,2]) self.assertEqual(ancestral_state_position(self.aln3,\ self.t3_2,1,self.ancestral_states3),[2,5]) def test_ancestral_state_pair_tree_difference(self): """ancestral_state_pair: different result on different tree """ # tree: t3_1 self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_1,0,1,self.ancestral_states3),5) self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_1,1,0,self.ancestral_states3),5) self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_1,0,0,self.ancestral_states3),7) self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_1,1,1,self.ancestral_states3),5) # tree: t3_2 self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_2,0,1,self.ancestral_states3),2) self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_2,1,0,self.ancestral_states3),2) self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_2,0,0,self.ancestral_states3),2) self.assertFloatEqual(ancestral_state_pair(self.aln3,\ self.t3_2,1,1,self.ancestral_states3),5) def test_ancestral_state_alignment_aln_difference(self): """ancestral_state_alignment: difference aln -> different result """ expected = [[0,0,0],[0,2,0],[0,0,7.8]] actual = ancestral_state_alignment(self.aln1_1,\ self.t1,self.ancestral_states1) self.assertFloatEqual(actual,expected) expected = [[5,5,5],[5,11.6,11.6],[5,11.6,11.6]] actual = ancestral_state_alignment(self.aln1_5,\ self.t1,self.ancestral_states1) self.assertFloatEqual(actual,expected) def test_ancestral_state_position_aln_difference(self): """ancestral_state_position: difference aln -> different result """ expected = [0,0,0] actual = ancestral_state_position(self.aln1_1,\ self.t1,0,self.ancestral_states1) self.assertFloatEqual(actual,expected) expected = [0,2,0] actual = ancestral_state_position(self.aln1_1,\ self.t1,1,self.ancestral_states1) self.assertFloatEqual(actual,expected) expected = [0,0,7.8] actual = ancestral_state_position(self.aln1_1,\ self.t1,2,self.ancestral_states1) self.assertFloatEqual(actual,expected) expected = [5,5,5] actual = ancestral_state_position(self.aln1_5,\ self.t1,0,self.ancestral_states1) self.assertFloatEqual(actual,expected) expected = [5,11.6,11.6] actual = ancestral_state_position(self.aln1_5,\ self.t1,1,self.ancestral_states1) self.assertFloatEqual(actual,expected) expected = [5,11.6,11.6] actual = ancestral_state_position(self.aln1_5,\ self.t1,2,self.ancestral_states1) self.assertFloatEqual(actual,expected) def test_ancestral_state_pair_aln_difference(self): """acestral_state_pair: different aln -> different result """ self.assertFloatEqual(ancestral_state_pair(self.aln1_1,self.t1,0,0,\ self.ancestral_states1),0) self.assertFloatEqual(ancestral_state_pair(self.aln1_1,self.t1,1,1,\ self.ancestral_states1),2) self.assertFloatEqual(ancestral_state_pair(self.aln1_1,self.t1,2,2,\ self.ancestral_states1),7.8) self.assertFloatEqual(ancestral_state_pair(self.aln1_5,self.t1,0,1,\ self.ancestral_states1),5) self.assertFloatEqual(ancestral_state_pair(self.aln1_5,self.t1,0,2,\ self.ancestral_states1),5) self.assertFloatEqual(ancestral_state_pair(self.aln1_5,self.t1,1,2,\ self.ancestral_states1),11.6) def test_ancestral_state_pair_symmetry(self): """ancestral_state_pair: value[i,j] == value[j,i] """ self.assertFloatEqual(ancestral_state_pair(self.aln1_5,self.t1,0,1,\ self.ancestral_states1),ancestral_state_pair(\ self.aln1_5,self.t1,1,0,self.ancestral_states1)) self.assertFloatEqual(ancestral_state_pair(self.aln1_5,self.t1,0,2,\ self.ancestral_states1),ancestral_state_pair(\ self.aln1_5,self.t1,2,0,self.ancestral_states1)) self.assertFloatEqual(ancestral_state_pair(self.aln1_5,self.t1,1,2,\ self.ancestral_states1),ancestral_state_pair(\ self.aln1_5,self.t1,2,1,self.ancestral_states1)) def est_ancestral_state_methods_handle_alt_null_value(self): """ancetral state methods handle non-default null value """ # need to rewrite a test of this -- right now there's no way to get # null values into the ancestral states result, but that will change # when I fix the exclude handling pass class GctmpcaTests(TestCase): def setUp(self): self.run_slow_tests = int(environ.get('TEST_SLOW_APPC',0)) self.run_gctmpca_tests = app_path('calculate_likelihood') # Data used by Gctmpca tests self.l1 = "1\t2\t42.60\n" self.l2 = "2\t3\t0.60" self.lines = ["Position 1\tPosition 2\tScore\n",self.l1,self.l2] self.aln = DenseAlignment(\ [('A1','AACF'),('A12','AADF'),('A123','ADCF')],\ MolType=PROTEIN) self.rna_aln = DenseAlignment(\ [('A1','AACU'),('A12','AAGG'),('A123','ADCA')],\ MolType=RNA) self.dna_aln = DenseAlignment(\ [('A1','AACT'),('A12','AAGG'),('A123','ADCA')],\ MolType=DNA) self.tree = LoadTree(treestring="(A1:0.5,(A12:0.5,A123:0.5):0.5);") self.aln4 = DenseAlignment([('A','AACF'),('AB','AADF'),\ ('ABC','ADCF'),('AAA','AADE')],\ MolType=PROTEIN) self.tree4 = LoadTree(treestring=\ "((A:0.5,AAA:0.5):0.5,(AB:0.5,ABC:0.5):0.5);") def test_parse_gctmpca_result_line(self): """Gctmpca: result line parsing functions as expected """ exp1 = (0,1,42.60) exp2 = (1,2,0.60) self.assertFloatEqual(parse_gctmpca_result_line(self.l1),exp1) self.assertFloatEqual(parse_gctmpca_result_line(self.l2),exp2) def test_parse_gctmpca_result(self): """Gctmpca: result (as list) yeilds correctly matrix """ exp1 = array([\ [gDefaultNullValue,42.60,gDefaultNullValue],\ [42.60,gDefaultNullValue,0.60],\ [gDefaultNullValue,0.60,gDefaultNullValue]]) self.assertFloatEqual(parse_gctmpca_result(self.lines,3),exp1) exp2 = array([\ [gDefaultNullValue,42.60,gDefaultNullValue,gDefaultNullValue],\ [42.60,gDefaultNullValue,0.60,gDefaultNullValue],\ [gDefaultNullValue,0.60,gDefaultNullValue,gDefaultNullValue],\ [gDefaultNullValue,gDefaultNullValue,\ gDefaultNullValue,gDefaultNullValue]]) self.assertFloatEqual(parse_gctmpca_result(self.lines,4),exp2) self.assertRaises(ValueError,parse_gctmpca_result,self.lines,2) def test_create_gctmpca_input(self): """Gctmpca: create_gctmpca_input generates proper data """ seqs1, tree1, seq_names, seq_to_species1 = \ create_gctmpca_input(self.aln,self.tree) exp_seqs1 = ['3 4','A1.. AACF', 'A12. AADF','A123 ADCF','\n'] exp_tree1 = ["(A1..:0.5,(A12.:0.5,A123:0.5):0.5);",'\n'] exp_seq_names = ["A1..","A12.","A123",'\n'] exp_seq_to_species1 = ["A1..\tA1..","A12.\tA12.","A123\tA123",'\n'] self.assertEqual(seqs1,exp_seqs1) self.assertEqual(tree1,exp_tree1) self.assertEqual(seq_names,exp_seq_names) self.assertEqual(seq_to_species1,exp_seq_to_species1) def test_gctmpca_pair(self): """Gctmpca: pair method works on trivial data """ if not self.run_slow_tests: return if not self.run_gctmpca_tests: return # Note: the values in here are derived from the results of running # this on the example data from the command line. # More extensive tests are performed # in the app controller test -- here I just want to make sure we're # getting the values out. actual = gctmpca_pair(self.aln,self.tree,2,3) expected = 0.483244 self.assertFloatEqual(actual,expected) actual = gctmpca_pair(self.aln4,self.tree4,2,3) expected = 0.164630 self.assertFloatEqual(actual,expected) # mol type = RNA actual = gctmpca_pair(self.rna_aln,self.tree,3,4) expected = 0.237138 self.assertFloatEqual(actual,expected) # mol type = DNA => error self.assertRaises(ValueError,gctmpca_pair,\ self.dna_aln,self.tree,2,3) def test_gctmpca_alignment(self): """Gctmpca: alignment method works on trivial data """ if not self.run_slow_tests: return if not self.run_gctmpca_tests: return # Note: the values in here are derived from the results of running # this on the example data from the command line. # More extensive tests are performed # in the app controller test -- here I just want to make sure we're # getting the values out. actual = gctmpca_alignment(self.aln,self.tree) expected = array([\ [gDefaultNullValue,gDefaultNullValue,\ gDefaultNullValue,gDefaultNullValue],\ [gDefaultNullValue,gDefaultNullValue,0.483244,gDefaultNullValue],\ [gDefaultNullValue,0.483244,gDefaultNullValue,1.373131],\ [gDefaultNullValue,gDefaultNullValue,1.373131,gDefaultNullValue]]) self.assertFloatEqual(actual,expected) def test_build_q_yields_roughly_gctmpca_default(self): """build_rate_matrix: from DSO78 data yields Yeang's default Q """ # Note: This doesn't reproduce the exact values, which I expect is # due to the two Dayhoff matrices in the PAML data. I think they're # using the second one (which is from Dayhoff et al., 1978) and we're # using the first one. What is the difference b/w these two? aa_order = 'ACDEFGHIKLMNPQRSTVWY' q = build_rate_matrix(DSO78_matrix,DSO78_freqs,aa_order=aa_order) expected = [] for row_aa in aa_order: expected.append([default_gctmpca_aa_sub_matrix[row_aa][col_aa] \ for col_aa in aa_order]) self.assertFloatEqual(q,expected,3) def test_build_q_ignores_zero_counts(self): """build_rate_matrix: recoded counts (i.e., w/ many 0s) yeilds right Q """ # Test that when working with reduced counts, counts and freqs # that equal 0.0 don't effect the calculation of Q. aa_order_3 = 'ACD' count_matrix_3 = [[0,3,9],[3,0,6],[9,6,0]] aa_freqs_3 = {'A':0.5,'C':0.3,'D':0.2} sm = Empirical(\ rate_matrix=array(count_matrix_3),\ motif_probs=aa_freqs_3,\ alphabet=Alphabet(aa_order_3),recode_gaps=True,do_scaling=True,\ name="",optimise_motif_probs=False) wprobs = array([aa_freqs_3[aa] for aa in aa_order_3]) mprobs_matrix=ones((wprobs.shape[0],wprobs.shape[0]),float)*wprobs q3 = sm.calcQ(wprobs, mprobs_matrix) aa_freqs_20 = {}.fromkeys('ACDEFGHIKLMNPQRSTVWY',0.0) aa_freqs_20['A'] = 0.5 aa_freqs_20['C'] = 0.3 aa_freqs_20['D'] = 0.2 count_matrix_20 = zeros(400).reshape(20,20) count_matrix_20[0,1] = count_matrix_20[1,0] = 3 count_matrix_20[0,2] = count_matrix_20[2,0] = 9 count_matrix_20[1,2] = count_matrix_20[2,1] = 6 q_20 = build_rate_matrix(array(count_matrix_20),aa_freqs_20) for i in range(20): for j in range(20): try: # rates in q_3 and q_20 are identical self.assertEqual(q3[i,j],q_20[i,j]) except IndexError: # and everything not in q_3 is zero self.assertEqual(q_20[i,j],0.) # following are support funcs for ResampledMiTests def make_freqs(c12): c1,c2=Freqs(),Freqs() for a,b in c12.expand(): c1 += a c2 += b return c1, c2 def make_sample(freqs): d=[] for i, s in enumerate(freqs.expand()): d += [("s%d" % i, s)] return LoadSeqs(data=d) def _calc_mi(): """one mutual info hand calc""" from math import log i = 37/42 * -log(37/42,2) - (5/42 * log(5/42,2)) j = 39/42 * -log(39/42,2) - (3/42 * log(3/42,2)) k = 34/42 * -log(34/42,2) - (3/42 * log(3/42,2)) - (5/42 * log(5/42,2)) return i+j-k class ResampledMiTests(TestCase): def setUp(self): self.c12 = Freqs() self.c12 += ['AA']*2 self.c12 += ['BB']*2 self.c12 += ['BC'] self.c1, self.c2 = make_freqs(self.c12) self.aln = make_sample(self.c12) def test_calc_weights(self): """resampled mi weights should be correctly computed""" w1 = make_weights(self.c1, 5) w2 = make_weights(self.c2, 5) e = [('A', {'C': 0.033333333333333333, 'B': 0.066666666666666666}), ('C', {'A': 0.050000000000000003, 'B': 0.050000000000000003}), ('B', {'A': 0.066666666666666666, 'C': 0.033333333333333333})] weights = [] for w in w1,w2: for k, d in w: weights += d.values() self.assertFloatEqual(sum(weights), 0.5) self.assertEqual(w2, e) def test_scaled_mi(self): """resampled mi should match hand calc""" def calc_scaled(data, expected_smi): col_i, col_j = Freqs(), Freqs() for i, j in data: col_i += i col_j += j pair_freqs = Freqs(data) weights_i = make_weights(col_i.copy(), col_i.Sum) weights_j = make_weights(col_j.copy(), col_j.Sum) entropy = mi(col_i.Uncertainty, col_j.Uncertainty, pair_freqs.Uncertainty) self.assertFloatEqual(entropy, _calc_mi()) scales = calc_pair_scale(data, col_i, col_j, weights_i, weights_j) scaled_mi = 1-sum([w*pair_freqs[pr] for pr, e, w in scales\ if entropy <= e]) self.assertFloatEqual(scaled_mi, expected_smi) data = ['BN', 'BN', 'BP', 'BN', 'PN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN', 'PN', 'BN', 'PN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BP', 'BN', 'BN', 'BN', 'BN', 'BP', 'BN', 'BN', 'BN', 'BN', 'PN', 'PN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN', 'BN'] calc_scaled(data, 8/42) def test_resampled_mi_interface(self): """resampled_mi_alignment should correctly compute statistic from alignment""" arr = resampled_mi_alignment(self.aln) # expected value from hand calculation self.assertFloatEqual(arr.tolist(), [[1.,0.78333333],[0.78333333,1.]]) ALN_FILE=\ """Seq_1 ACDEFG Seq_2 STVWY- Seq_3 WY.ZBX""" #J in here ALN_FILE_WRONG_KEY=\ """Seq_1 ACDKLM Seq_2 JINCK- Seq_3 VX.MAB""" #last seq too long ALN_FILE_INC_SHAPE=\ """Seq_1 ACDKLM Seq_2 LINCK- Seq_3 VX.MABN""" gpcr_ungapped = """>OPSD_SPAAU MNGTEGPFFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWIMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFSIPLTIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVIAFLVCWLPYAGVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >B1AR_CANFA LPDGAATAARLLVPASPSASPLAPTSEGPAPLSQQWTAGIGLLMALIVLLIVAGNVLVIAAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVMRGRWEYGSFLCELWTSVDVLCVTASIETLCVIALDRYLAITAPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRRAFQRLLCCARRAARGSHGAAG------PPPSPG >OPSB_HUMAN ---MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTD---ESDTCSTVSSTQVGPN- >OPSD_PROCL NP-Y-GNFTVVDMAPKDILHMIHPHWYQYPPMNPMMYPLLLIFMLFTGILCLAGNFVTIWVFMNTKSLRTPANLLVVNLAMSDFLMMFTMFPPMMVTCYYHTWTLGPTFCQVYAFLGNLCGCASIWTMVFITFDRYNVIVKGVAGEPLSTKKASLWILTIWVLSITWCIAPFFGWNRYVPEGNLTGCGTD--YLSEDILSRSYLYDYSTWVYYLPLLP-IYCYVSIIKAVAAHMGIRNEEAQKTSAECRLAKIAMTTVALWFIAWTPYLLINWVGMFARSY-LSPVYTIWGYVFAKANAVYNPIVYAISHPKYRAAMEKKLPCLSCKTESDDVSESAEEKAESA---- >BRB1_RABIT ASQGPLELQPSNQSQLAPPNATSC--SGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSVFLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANLFISIFLVVAISQDRYSVLVHPMSRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRA-LN--SACILL---LPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRR---RVPSRCGGPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHEFTDLGLQLSNFSAFVNSCLNPVIYVFVGRLFRTKVWELCQQCSPR---------LAPV-------S >5H7_.ENLA NLLPSEFMTERPLNTTEQDLTKPDCGKELLLYGDTEKIVIGVVLSIITLFTIAGNALVIISVCIVKKLRQPSNYLVVSLAAADLSVAVAVMPFVIITDLVGGWLFGKVFCNVFIAMDVMCCTASIMTLCVISVDRYLGITRPLYPARQNGKLMAKMVFIVWLLSASITLPPLFGWAK--N-V--RVCLIS--------QDFGYTVYSTAVAFYIPMTVMLVMYQRIFVAAKISSKLDRKNISIFKREQKAARTLGIIVGAFTFCWLPFFLLSTARPFICGICMPLRLERTLLWLGYTNSLINPLIYAFFNRDLRTTFWNLLRCKYTNINRRLSAASTERHEGIL---- >B3AR_FELCA MAPWPHGNGSLASWPDAPTLTPNTANTSGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--HCCAFA--------SNIPYALLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALRTLGLIMGTFSLCWLPFFVANVVRALGGPS-VPSPAFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCRLEERHAAASGAAALTRPAESGLP >TLR1_DROME IIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVDPL-KRRTSRRKVRIILVLIWALSCVLSAPCLLYSS----SR--TVCFMMDGRYPTSMADYAYNLIILVLTTGIPMIVMLICYSLMGRVPGGSSIGTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPNSSNRHTRAETK >ITR_CATCO EQDFWSFNESSRNSTVGNETF-GNQTVNPLKRNEEVAKVEVTVLALVLFLALAGNLCVLIAIYTAKHTQSRMYYLMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQTVGMFASTYMLVLMSIDRCIAICQPL--RSLHKRKDRCYVIVSWALSLVFSVPQVYIFSLRE----VYDCWGD---FVQPWGAKAYITWISLTIYIIPVAILGGCYGLISFKIWQNANAVSSVKLVSKAKITTVKMTFVIVLAYIVCWTPFFFVQMWSAWDPEA-REAMPFIISMLLASLNSCCNPWIYMFFAGHLFHDLKQSLLCCSTLYLKSSQCRCKSNCSTYVIKST >NK1R_RANCA ----MNSNISAQNDSALNSTIQNGTKINQFIQPPWQIALWSVAYSIIVIVSLVGNIIVMWIIIAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNHWYYGLIYCKFHNFFPISAVFTSIYSMTAIALDRYMAIIHPL-KPRLSATATKIVICVIWSFSFCMAFPLGYYAD---GG---DICYLNPDSEENRKYEQVYQVLVFCLIYILPLLVIGCAYTFIGMTLWAS--PSDRYHEQVVAKRKVVKMMIVVVCTFAICWLPFHIFFLLQTLHEMTKFYQQFYLAIMWLAMSSTMYNPIIYCCLNDRFRIGFKHVFRWCPFIRAGEY----STRYLQTQSSMY >A2AA_MOUSE ----MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGQ-P--PSCKIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRRGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCP--VPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >MSHR_VULVU SGQGPQRRLLGSPNATSPTTPHFKLAANQTGPRCLEVSIPNGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYY----------------------NNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQHIARKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSW----------------------- >OPSD_BOVIN MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA >OPSG_MOUSE DHYEDSTHASIFTYTNSNSTKGPFEGPNYHIAPRWVYHLTSTWMILVVVASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAIWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILHLFGKKVDDS-----SELVSSV--SSVSPA >TA2R_RAT --MWLNS-----------TSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLTDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLT----LGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQ------------ >CCR3_HUMAN LENFSSSYDYGENESDSCCTSPPC---PQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHH-RL-ATHCQYN----FPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVL---------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGSRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPN----QRGL--------PSSS >THRR_CRILO LPEGRAIYLNKSHSPPAPLAPFISEDASGYLTSPWLRLFIPSVYTFVFVVSLPLNILAIAVFVLKMKVKKPAVVYMLHLAMADVLFVSVLPLKISYYFSGSDWQFGSGMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPISLSWRTLGRANFTCLVIWVMAIMGVVPLLLKEQTTR--N--TTCHDVLNETLLQGFYSYYFSAFSAVFFLVPLIISTICYMSIIRCL------SSSSVANRSKKSRALFLSAAVFCVFIVCFGPTNVLLIMHYLLLSDEKAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYGILCCKESSDPNSYNSTGDTCS-------- >AA2A_CAVPO ----------------------------------MSSSVYITVELVIAVLAILGNVLVCWAVWINSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFFACFVLVLTQSSIFSLLTITIDRYIAIRIPLYNGLVTCTRAKGIIAICWVLSFAIGLTPMLGWNNCSS-E-QVTCLFE-----DVVPMNYMVYYNFFAFVLVPLLLMLGIYLRIFLAARRQESQGERTRSTLQKEVHPAKSLAIIVGLFALCCLPLNIINCFTFFCPECHAPPWLMYLTIILSHGNSVVNPLIYAYRIREFRQTFRKIIRSHILRRRELFKAGGAHSPEGEQVSLR >C3AR_MOUSE --------------MESFDADTNSTDLHSRPLFQPQDIASMVILGLTCLLGLLGNGLVLWVAGVKMK-TTVNTVWFLHLTLADFLCCLSLPFSLAHLILQGHWPYGLFLCKLIPSIIILNMFASVFLLTAISLDRCLIVHKPICQNHRNVRTAFAICGCVWVVAFVMCVPVFVYRDLFI-ED-DYVDQFT-YDNHVPTPLMAITITRLVVGFLVPFFIMVICYSLIVFRM--------RKTNFTKSRNKTFRVAVAVVTVFFICWTPYHLVGVLLLITDPEEAVMSWDHMSIALASANSCFNPFLYALLGKDFRKKARQSIKGILEAAFSEELTHSASS--------- >TA2R_BOVIN --MWPNA-----------SSLGPCFRPMNITLEERRLIASPWFAASFCLVGLASNLLALSVLMGARQSRSSFLTFLCGLVLTDFMGLLVTGAIVVTQHFVLFVDPGCSLCHFMGVIMVFFGLCPLLLGAAMASERFLGITRPFRPATASQRRAWTTVGLVWASALALGLLPLLGVGHYTVQYPGSWCFLT----LGTDPGDVAFGLLFALLGSISVGMSFLLNTISVATLCHVYHGATAQQRPRDCEVEMMVQLMGIMVVASICWMPLLVFIAQTVLQSPPRLTERQLLIYLRVATWNQILDPWVYILFRRAVIQRFYPRLSTRSRSLSLQPQLTR------------ >OPSD_RABIT MNGTEGPDFYIPMSNQTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATASKTETSQVAPA >OPSD_PHOVI MNGTEGPNFYVPFSNKTGVVRSPFEFPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVGFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTLPAFFAKAASIYNPVIYIMMNKQFRTCMITTLCCGKNPLGDDEVSASASKTETSQVAPA >D3DR_RAT --------MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN---D-P--SICSI---------SNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRTSLPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC------------------------- >DADR_.ENLA ---------------MTFNITSMDEDVLLTERESSFRVLTGCFLSVLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-TFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKVAFIMIGVAWTLSVLISFIPVQLNWHKALN-TMDNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAAKQLDCESSLKTSFKRETKVLKTLSVIMGVFVCCWLPFFILNCIVPFCDPSCISSTTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSNLLGCYRLCPTSNNIIETAVVYSCQ----- >PAR2_HUMAN ---VDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIF--N--TTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRML------SAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLKSSS-------- >GPRA_RAT TPANQSAEASESNVSATVPRAAAVTPFQSLQLVHQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLTLAYAFEPRWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPL-RRRISLKLSAYAVLGIWALSAVLALPAAVHTYHVEHD--VRLCEEF--WGSQERQRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLRNRPGS-SQADWDRARRRRTFCLLVVVVVVFALCWLPLHIFNLLRDLDPRAYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKMLLSWPRKIVPHGQNMT------------ >ET1R_PIG EFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPKT--HKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPWKNHEQNNHNTE >NTR2_MOUSE -----METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARTRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLARRLLTPRRTCRLLSLVWVASLGLALPMAVIMGQKH--AASRVCTVL---VSRASSRSTFQVKRAGLLRSPLWELTAILNGITVNHLVALVQARHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQSTYSFRLWGSPR >CKR7_MOUSE QDEVTDDYIGENTTVDYTLYESVC---FKKDVRNFKAWFLPLMYSVICFVGLLGNGLVILTYIYFKRLKTMTDTYLLNLAVADILFLLILPFWAYSEAKS--WIFGVYLCKGIFGIYKLSFFSGMLLLLCISIDRYVAIVQAVRHRARVLLISKLSCVGIWMLALFLSIPELLYSGLQK-GE-TLRCSLV---SAQVEALITIQVAQMVFGFLVPMLAMSFCYLIIIRTL---------LQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNKQLNIAYDVTYSLASVRCCVNPFLYAFIGVKFRSDLFKLFKDLGCLSQERLRHWS--------HVRN >NY5R_HUMAN -------------NTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVESS--RYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGVHEKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM---------------------- >VG74_HSVSA VKLDFSSEDFSNYSYNYSGDIYYGDVAPCVVNFLISESALAFIYVLMFLCNAIGNSLVLRTFLKYRA-QAQSFDYLMMGFCLNSLFLAGYLLMRLLRMFE--IFMNTELCKLEAFFLNLSIYWSPFILVFISVLRCLLIFCATRLWVKKTLIGQVFLCCSFVLACFGALPHVMVTSYYE----PSSCIEE---VLTEQLRTKLNTFHTWYSFAGPLFITVICYSMSCYKL---------FKTKLSKRAEVVTIITMTTLLFIVFCIPYYIMESIDTLLRVGSAIVYGIQCTYMLLVLYYCMLPLMFAMFGSLFRQRMAAWCKTICHC--------------------- >CCKR_HUMAN DSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTANMCRFL---LPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGRANSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVTTGASLSRFSYS >OPSR_CARAU GD--ETTRESMFVYTNSNNTRDPFEGPNYHIAPRWVYNLATVWMFFVVVASTFTNGLVLVATAKFKKLRHPLNWILVNLAVADLAETLLASTISVTNQFFGYFILGHPMCIFEGFTVSVCGIAGLWSLTVISWERWVVVCKPFGNVKFDAKWASAGIIFSWVWSAIWCAPPIFGWSRFWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIILCYIAVWLAIRTVAQQQKDSESTQKAEKEVSRMVVVMIFAYCFCWGPYTFCACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQFRVCIMQLFGKKVDDG-----SEVSS------VAPA >OPS2_LIMPO PN-----ASVVDTMPKEMLYMIHEHWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFMMPTMASNCFAETWILGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAAPLTHKKATLLLLFVWIWSGGWTILPFFGWSRYVPEGNLTSCTVD--YLTKDWSSASYVIIYGLAVYFLPLITMIYCYFFIVHAVAEHNVAANADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIIAWAGVFSSGTRLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLACGSGESGSDVKTMEEKPKSPEA- >O5I1_HUMAN -----------MEFTDRNYTLVTEFILLGFPTRPELQIVLFLMFLTLYAIILIGNIGLMLLIRIDPHLQTPMYFFLSNLSFVDLCYFSDIVPKMLVNFLSENKSISYYGCALQFYFFCTFADTESFILAAMAYDRYVAICNPLYTVVMSRGICMRLIVLSYLGGNMSSLVHTSFAFIL---KNHFFCDLPKLSCTDTTINEWLLSTYGSSVEIICFIIIIISYFFILLSV--------LKIRSFSGRKKTFSTCASHLTSVTIYQGTLLFIYSRPSYLY---SPNTDKIISVFYTIFIPVLNPLIYSLRNKDVKDAAEKVLRSKVDSS-------------------- >OAR_HELVI --TEEVIEDDRDACAVADDPKYPSSFGITLAVPEWEAICTAIVLTLIIISTIVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPIYAQKRTLERVLLMIGVVWVLSLIISSPPLLGWNDW-E-P--TPCRLT--------SQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRAVYEEKQRISLTRERRAARTLGIIMGVFVVCWLPFFVIYLVIPFCASCCLSNKFINFITWLGYCNSALNPLIYTIFNMDFRRAFKKLLCMKP----------------------- >O1D4_HUMAN -------------MDGDNQSENSQFLLLGISESPEQQQILFWMFLSMYLVTVLGNVLIILAISSDSHLHTPMYFFLANLSFTDLFFVTNTIPKMLVNFQSQNKAISYAGCLTQLYFLVSLVTLDNLILAVMAYDRYVAICCPLYVTAMSPGLCVLLLSLCWGLSVLYGLLLTFLLTRV---THYLFCDMYWLACSNTHIIHTALIATGWFIFLTLLGFMTTSYVRIVRTI--------LQMPSASKKYKTFSTCASHLGVVSLFYGTLAMVYLQPLHTY----SMKDSVATVMYAVLTPMMNPFIYSLRNKDMHGAPGRVLWRPFQRP-------------------- >OPSD_APIME AR-F-NNQTVVDKVPPDMLHLIDANWYQYPPLNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNFLMMFCMSPPMVINCYYETWVLGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSGKPLSINGALIRIIAIWLFSLGWTIAPMFGWNRYVPEGNMTACGTD--YFNRGLLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHMNVRSSENQNTSAECKLAKVALMTISLWFMAWTPYLVINFSGIFNLVK-ISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFAKFPSLACAAEPSSDAVSVTDNEKSNA--- >TRFR_CHICK ----------MENGTGDEQNHTGLLLSSQEFVTAEYQVVTILLVLLICGLGIVGNIMVVLVVLRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITESLYKSWVYGYVGCLCITYLQYLGINASSFSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWSFASVYCMLWFFLLDLN--DT-VVSCGYK------RSYYSPIYMMDFGIFYVLPMVLATVLYGLIARILFLNVNSNKSFNSTIASRRQVTKMLAVVVVLFAFLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCHLKRDKKPANYSVKESDHFSSEIED >OPSR_HUMAN DSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDG-----SELVSSV--SSVSPA >CB2R_MOUSE ----MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHG-VDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPYKALVTRGRALVALCVMWVLSALISYLPLMGWTC-----CPSPCSEL------FPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHAEHQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKVTETEADVKTT- >PE21_HUMAN --MSPCGPLNLSLAGEATTCAA---PWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGSATTFLLFVASLLATDLAGHVIPGALVLRLYTAG-RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIG--LGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALHRSRRRAHGPRRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLSSLRSSRHSGLS >OPR._CAVPO GSHLQGNLSLLSPNHSGLPPHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQATDILLGF-WPFGNTLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALALVVGVPVAIMGSAQVEE---IECLVE-IPDPQDYWGPVFAVSIFLFSFIIPVLIISVCYSLMIRRLHGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETTVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVALGCKTTETVPR >OPSV_CHICK -----MSSDDDFYLFTNGSVPGPWDGPQYHIAPPWAFYLQTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHGGLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWSRYMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRAVAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQFRACIMETVCGKPLTD--DSDASTSSVSSSQVGPT- >YKR5_CAEEL MNSENGLDSVTQIMYDMKKYNIVNDVLPPPNHEDLHVVIMAVSYLLLFLLGTCGNVAVLTTIYHVIRTLDNTLIYVIVLSCVDFGVCLSLPITVIDQILGF-WMFGKIPCKLHAVFENFGKILSALILTAMSFDRYAGVC---------HPQRKRLRSRNFAITILLAPGMLTRM-------KIEKCTVD----IDSQMFTAFTIYQFILCYCTPLVLIAFFYTKLLSKLRE----TRTFKSSQIPFLHISLYTLAVACFYFLCWTPFWMATLFAVYLENSPVFVYIMYFIHALPFTNSAINWILYGRVFLETVS--------------------------------- >5H1B_MOUSE CAPPPPAASQTGVPLTNLSHNSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPKRAAIMIVLVWVFSISISLPPFFWR----E-E--LDCFVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG--------------------- >P2YR_HUMAN AAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTG----KTITCYDT-TSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLPEFKQNGDTSL >5H4_CAVPO ------------------MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIRK-NSTYCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHGRPDQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT-VPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTINGSTHVLR-- >MC4R_PIG GMHTSLHFWNRSTYGLHSNASEPLGKGYSEGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALYHNIMTVKRVGIIISCIWAVCTVSGVLFIIYYS----------------------DDSSAVIICLITVFFTMLALMASLYVHMFLMARLH-RIPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY------------ >SSR1_MOUSE GEGACSRGPGSGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAADG--TVACNML-MPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQ--DDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLS-----WMDNAAETALKSRAYSVED >CML1_HUMAN EDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN-SS--WPTHSQ-MDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------HRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK-FKVALFSRLVNALSEDTGHSFTKMSSMNERTS >ACM1_RAT ------------MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >MRG_HUMAN QNPNLVSQLCGVFLQNETNETIHMQMSMAVGQQALPLNIIAPKAVLVSLCGVLLNGTVFWLLCCGAT--NPYMVYILHLVAADVIYLCCSAVGFLQVTLLTYHGVVFFIPDFLAILSPFSFEVCLCLLVAISTERCVCVLFPIYRCHRPKYTSNVVCTLIWGLPFCINIVKSLFLTYWK-------------------KACVIFLKLSGLFHAILSLVMCVSSLTLLIRFL--------CCSQQQKATRVYAVVQISAPMFLLWALPLSVAPLITDF----KMFVTTSYLISLFLIINSSANPIIYFFVGSLRKKRLKESLRVILQRALADKPEVGIDPMEQPHSTQH >A2AC_RAT AEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ----------------- >OPSD_SEPOF ---MGRDIPDNETWWYNPTMEVHPHWKQFNQVPDAVYYSLGIFIGICGIIGCTGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFIKWVFGMAACKVYGFIGGIFGLMSIMTMSMISIDRYNVIGRPMASKKMSHRRAFLMIIFVWMWSTLWSIGPIFGWGAYVLEGVLCNCSFD--YITRDSATRSNIVCMYIFAFCFPILIIFFCYFNIVMAVSNHRLNLRKAQAGASAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPLIYSVSHPKFREAIAENFPWIITCCQFDEKEVEEIPATEQS-GGE >SSR3_HUMAN SVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR-----STCHMQ-WPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSARVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGEDEEEEDG---E >O.1R_HUMAN MGVPPGSREPSPVPPDYED-EFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSRTRLFSVCDER---WADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQPRFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKASHKS---LSLQS >O2C1_HUMAN -------------MDGVNDSSLQGFVLMSISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSRLEARLHTPMYFFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAFDRYVAVCRPLYTAIMNPQLCWLLAVIAWLGGLGNSVIQSTFTLQL---PEGFLCEVPKLACGDTSLNQAVLNGVCTFFTAVPLSIIVISYCLIAQAV--------LKIHSAEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPAKNS---KQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGALRRLLGKGREVG-------------------- >OPSD_MOUSE MNGTEGPNFYVPFSNVTGVGRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLCCGKNPLGDDDASATASKTETSQVAPA >CB1R_TARGR EFFNRSVSTFKENDDNLKCGENFMDMECFMILTASQQLIIAVLSLTLGTFTVLENFLVLCVILQSRTRCRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHR-KDSSNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRTKAVIAFCVMWTIAIIIAVLPLLGWNCK-K--LKSVCSDI------FPLIDENYLMFWIGVTSILLLFIVYAYVYILWKAHSHSEDQITRPEQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNNPIKTVFAFCSMLCLMDSTVNPIIYALRSQDLRHAFLEQCPPCEGTSQPLDNSMEGNN-AGNVHRAA >B2AR_HUMAN MGQPGNGSAFLLAPNRSHAPDH----DVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQGRTLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IRKEVYILLNWIGYVNSGFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGYSGNTGEQSGYHVE >OPSD_ZOSOP MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYACLGAYMFFLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFCIPLAVVGFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVIGFLVCWLPYASVAWYIFTHQGSEFGPPFMTVPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTVSSSSVSPAA-- >GP37_HUMAN LAQNGSLGEGIHEPGGPRRGNRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKI-K--KISPDLTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKATRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTYTTELELSPFST >OPSR_CHICK HEEEDTTRDSVFTYTNSNNTRGPFEGPNYHIAPRWVYNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDG-----SEVVSSVSNSSVSPA >IL8B_BOVIN EGFEDEFGNYSGTPPTEDYDYSPC----EISTETLNKYAVVVIDALVFLLSLLGNSLVMLVILYSRIGRSVTDVYLLNLAMADLLFAMTLPIWTASKAKG--WVFGTPLCKVVSLLKEVNFYSGILLLACISMDRYLAIVHATRTLTQKWHWVKFICLGIWALSVILALPIFIFREAYQ-YS-DLVCYED-LGANTTKWRMIMRVLPQTFGFLLPLLVMLFCYGFTLRTL---------FSAQMGHKHRAMRVIFAVVLVFLLCWLPYNLVLIADTLMRAHNDIGRALDATEILGFLHSCLNPLIYVFIGQKFRHGLLKIMAIHGLISKEFLAKDG------------ >OPSD_MACFA MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNAEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLFGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEARAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSASIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA >5H2B_RAT ILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEA-NA---ITCELT------KDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKRRMGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKGNSMVENSKFFT >OPSR_ANOCA NDEDDTTRDSLFTYTNSNNTRGPFEGPNYHIAPRWVYNITSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTCGISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWSRYWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRAVAAQQKESESTQKAEKEVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIMQLFGKKVDDG-----SELVSSVSNSSVSPA >5H1A_MOUSE -MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRA---NP--NECTIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRKNEEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR--------------------- >CCR4_HUMAN IYTSDNYTEEMG-SGDYDSMKEPC---FREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >CKR3_MACMU MTTSLDTVETFGPTSYDDDMGLLC---EKADVGALIAQFVPPLYSLVFMVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRERN-WVFSHGMCKVLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIVTWGLAVLAALPEFIFYGTEK-LF-KTLCSAIYPQDTVYSWRHFHTLKMTILCLALPLLVMAICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILISTYQSVLKHLDLFVLATEVIAYSHCCVNPVIYAFVGERFRKYLRHFFHRHVLMHLGKYIPFLT-------SSVS >OPSD_GLOME MNGTEGLNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYIPLNLAVANLFMVFGGFTTTLYTSLHAYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWVMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTSRQEVNNESFVIYMFVVHFTIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFTHQGSDFGPIFMTIPSFFAKSSSIYNPVIYIMMNKQLRNCMLTTLCCGRNPLGDDEASTTASKTETSQVAPA >FMLR_MOUSE ---MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMK-HTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPSPWPVEKRKVA------VTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKI---------HRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVREPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTGT---------- >OPSD_LAMJA MNGTEGDNFYVPFSNKTGLARSPYEYPQYYLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWSRYIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKEAAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTLCCGKNPLGDDESGASVSSVSTSPVSPA >C5AR_CAVPO ---MMVTVSYDYDYNSTFLPDGFVD--NYVERLSFGDLVAVVIMVVVFLVGVPGNALVVWVTACEAR-RHINAIWFLNLAAADLLSCLALPILLVSTVHLNHWYFGDTACKVLPSLILLNMYTSILLLATISADRLLLVLSPICQRFRGGCLAWTACGLAWVLALLLSSPSFLYRRTHN-SF--VYCVTD-YG-RDISKERAVALVRLLVGFIVPLITLTACYTFLLLRT---------WSRKATRSAKTVKVVVAVVSSFFVFWLPYQVTGILLAWHSPNRNTKALDAVCVAFAYINCCINPIIYVVAGHGFQGRLLKSLPSVLRNVLTEESLDKSTVD-------- >P2Y8_.ENLA ATSYPTFLTTPYLPMKLLMNLTNDTEDICVFDEGFKFLLLPVSYSAVFMVGLPLNIAAMWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPFGEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPISLRRMNAKHAYVICALVWLSVTLCLVPNLIFVTVS-----NTICHDT-TRPEDFARYVEYSTAIMCLLFGIPCLIIAGCYGLMTRELMKP---SGNQQTLPSYKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLLNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRRRSSVPNRRCMHTNMTAGPLPVISAE >5H1D_FUGRU ELDNNSLDYFSSNFTDIPSN--TTVAHWTEATLLGLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLAVTDMLVSILVMPISIVYTVSKTWSLGQIVCDIWLSSDITFCTASILHLCVIALDRYWAITDALYSKRRTMRRAAVMVAVVWVISISISMPPLFWR----H-E--KECMVN-------TDQISYTLYSTFGAFYVPTVLLIILYGRIYVAARSRKLALERKRLCAARERKATKTLGIILGAFIICWLPFFVVTLVWAICKEC-FDPLLFDVFTWLGYLNSLINPVIYTVFNDEFKQAFQKLIKFRR----------------------- >5HT_LYMST TGQFINGSHSSRSRDNASANDTDDRYWSLTVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVLVMPLSVVSEISKVWFLHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTSI-YIRRRSARRILLMIMVVWIVALFISIPPLFGWRD-PD-K--GTCIIS--------QDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRNDTRTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPFVDPEGIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKYRRGHR------------------ >5H6_HUMAN -----------MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPARNTS-NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH---E-VPGQCRLL--------ASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQVESRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASSGPRPG-LSLQQ >AG2R_MERUN ------MALNSSADDGIKRIQDDC---PKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPVWAVYTAMEYRWPFGNHLCKIASAGISFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCVVIWLLAGLASLPAVIHRNVYF-TN--TVCAFH-YESQNSTLPVGLGLTKNILGFMFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFRIIMAIVLFFFFSWIPHQIFTFLDVLIQLGDVVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------N >GRHR_HORSE --MANSDSLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPL-AVQSNSKLEQSMISLAWILSIVFAGPQLYIFRMIYTV--FSQCVTH--SFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVPRKNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >REIS_TODPA ---------------------MFGNPAMTGLHQFTMWEHYFTGSIYLVLGCVVFSLCGMCIIFLARQKPRRKYAILIHVLITAMAVNGGDPAHASSSIVGR-WLYGSVGCQLMGFWGFFGGMSHIWMLFAFAMERYMAVCHREFYQQMPSVYYSIIVGLMYTFGTFWATMPLLGWASYGLEVHGTSCTIN--YSVSDESYQSYVFFLAIFSFIFPMVSGWYAISKAWSGLSAIPD-EKEKDKDILSEEQLTALAGAFILISLISWSGFGYVAIYSALTHGGQLSHLRGHVPPIMSKTGCALFPLLIFLLTARSLPKSDTKKP-------------------------- >GRPR_RAT NCSHLNLEVDPFLSCNNTFNQTLSPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPQT--FISCAPY---HSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSLPVNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNR--SHSMTSFKSTNP-SA >CKR5_MACMU ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >B4AR_MELGA --------------MTPLPAGNGSVPNCSWAAVLSRQWAVGAALSITILVIVAGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLSGHWPYGTVVCELWTSLDVLCVTASIETLCAIAVDRYLAITAPLYEALVTKGRAWAVVCMVWAISAFISFLPIMNHWWRDV-R--RCCDFV--------TNMTYAIVSSTVSFYVPLLVMIFVYVRVFAVATRHSRGRRPSRLLAIKEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRPL-VPDQLFLFLNWLGYVNSAFNPIIYCRSP-DFRSAFRKLLCCPRRADRRLHAAPQAFSPRGDPMEDS >OPSV_.ENLA -----MLEEEDFYLFKNVSNVSPFDGPQYHIAPKWAFTLQAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLTGLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWSRYMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRAVAAQQQESASTQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQFRGCIMETVCGRPMSD--DSSVSSSTVSSSQVSPA- >OPSG_ORYLA ENGTEGKNFYIPMNNRTGLVRSPYEYPQYYLADPWQFKLLGIYMFFLILTGFPINALTLVVTAQNKKLRQPLNFILVNLAVAGLIMVCFGFTVCIYSCMVGYFSLGPLGCTIEGFMATLGGQVSLWSLVVLAIERYIVVCKPMGSFKFTATHSAAGCAFTWIMASSCAVPPLVGWSRYIPEGIQVSCGPDYYTLAPGFNNESFVMYMFSCHFCVPVFTIFFTYGSLVMTVKAAAAQQQDSASTQKAEKEVTRMCFLMVLGFLLAWVPYASYAAWIFFNRGAAFSAMSMAIPSFFSKSSALFNPIIYILLNKQFRNCMLATIGMGG-----------VSTSKTEVSTAA >NY6R_RABIT --MEVSLNDPASNKTSAKSNSSAFFYFESCQSPSLALLLLLIAYTVVLIMGICGNLSLITIIFKKQRAQNVTNILIANLSLSDILVCVMCIPFTAIYTLMDRWIFGNTMCKLTSYVQSVSISVSIFSLVLIAIERYQLIVNPR-GWKPSASHAYWGIMLIWLFSLLLSIPLLLSYHLTDSH--HVVCVEH---WPSKTNQLLYSTSLIMLQYFVPLGFMFICYLKIVICLHKRNSKRRENESRLTENKRINTMLISIVVTFAACWLPLNTFNVIFDWYHEVCHHDLVFAICHLVAMVSTCINPLFYGFLNRNFQKDLVVLIHHCLCFALRERY---TLHTDESKGSLR >CCR4_BOVIN IFTSDNYTEDDLGSGDYDSMKEPC---FREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVAN--WYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQKPRKLLAEKVVYVGVWLPAVLLTIPDLIFADIKE-DE-RYICDRF---YPSDLWLVVFQFQHIVVGLLLPGIVILSCYCIIISKL---------SHSKGYQKRKALKTTVILILTFFACWLPYYIGISIDSFILLESTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >OPS2_SCHGR YESSVGLPLLGWNVPTEHLDLVHPHWRSFQVPNKYWHFGLAFVYFMLMCMSSLGNGIVLWIYATTKSIRTPSNMFIVNLALFDVLMLLEMPMLVVSSLFYQR-PVWELGCDIYAALGSVAGIGSAINNAAIAFDRYRTISCPI-DGRLTQGQVLALIAGTWVWTLPFTLMPLLRIWSRFAEGFLTTCSFD--YLTDDEDTKVFVGCIFAWSYAFPLCLICCFYYRLIGAVREHNVKSNADTEAQSAEIRIAKVALTIFFLFLCSWTPYAVVAMIGAFGNRAALTPLSTMIPAVTAKIVSCIDPWVYAINHPRFRAEVQKRMKWLHLGEDARSSKSDRTVGNVSASA-- >DADR_HUMAN --------------MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-TIDNCDSS--------LSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPATNNAIETAAMFSSH----- >THRR_HUMAN LTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMSLSWRTLGRASFTCLAIWALAIAGVVPLVLKEQTIQ--N--TTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCL------SSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHEAAYFAYLLCVCVSSISSCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGDTCS-------- >V2R_HUMAN MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNSG--VTDCWAC---FAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASGRRPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA-LEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDSSLAKDTSS--- >GALR_HUMAN ----MELAVGNLSEGNASCPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLF-SN--QTFCWEQ---WPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLK--NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKEPPSTNCTHV--- >5H7_RAT SSWMPHLLSGFLEVTASPAPTNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSSRLERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERSEFVLQ >UL33_RCMVM ----MDVLLGTEELEDELHQLHFNYTCVPSLGLSVARDAETAVNFLIVLVGGPMNFLVLATQMLSNRSVSTPTLYMTNLYLANLLTVATLPFLMLSNRGL--VGSSPEGCKIAALAYYATCTAGFATLMLIAINRYR-VIHQRRSGAGSKRQTYAVLAVTWLASLMCASPAPLYATVMAA-DAFETCIIYSYDQVK-TVLATFKILITMIWGITPVVMMSWFYVFFYRRL---------KLTSYRRRSQTLTFVTTLMLSFLVVQTPFVAIMSYDSYGVLNNKRDAVSMLARVVPNFHCLLNPVLYAFLGRDFNKRFILCISGKLFSRRRALRERAGPVCALP---SK >O.YR_MOUSE GTPAANWSIELDLGSGVPPGAEGNLTAGPPRRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASVPQVHIFSLRE----VFDCWAV---FIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSARYLKGSRPGENSSTFVLSRCSS >PF2R_RAT --MSINS---------SKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSNSLAIAILMKAYQSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKFDQSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLHSTKITSKHVKMILSGVCMFAVFVALLPILGHRDYQIQASRTWCFYN--TEHIEDWEDRFYLLFFSSLGLLALGISFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAINGNNPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELKVAAISESPAA >D1DR_FUGRU --------------MAQNFSTVGDGKQMLLERDSSKRVLTGCFLSLLIFTTLLGNTLVCVAVTKFRHRSKVTNFFVISLAISDLLVAILVMPWKAATEIMGFWPFG-EFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKVACLMISVAWTLSVLISFIPVQLNWHKALN-PPDNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQSLSECSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCEADCISSTTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSILLGCHRLCPGNS-AIEIAPLSNPSCQYQP >CKR2_RAT HSLFPRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANE--WVFGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSEQ-ED-QHTCGPY----FPTIWKNFQTIMRNILSLILPLLVMVICYSGILHTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQEFLMHLDQAMQVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFRKHIAKNLCKQCPVFVSSTFTPSTGEQ >OPRK_HUMAN PPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVDVD-VIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVAYLRDIDGMNKP >ACM3_BOVIN N---------ISRAAGNLSSPNGTTSDPLGGHTIWQVVFIAFLTGVLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFILWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRNTFKMLLLCQCDKRKRRKQQYQHKRVPEQAL--- >C3.1_HUMAN ---MDQFPESVTENFEYDDLAEAC---YIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKG--LHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAASMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKE-----NECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTL---------FSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDRSRHGSVLSSNF >5H4_HUMAN ------------------MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIRK-NSTYCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHSRPDQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTINGSTHVLRDA >5H2A_PIG NTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEREPGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILAYKSSQLQTGQK >OPSD_DIPVU MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMALACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFSIPLLVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVIAFLVCWLPYASVAWWIFTHQGSDFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >HH1R_HUMAN ----------MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFM--VR-EDKCETD------FYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHLRSQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNC-CNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS----------------------- >OPSD_DELDE MNGTEGLNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVANLFMVFGGFTTTLYTSLHAYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWIMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTLSPEVNNESFVIYMFVVHFTIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFTHQGSDFGPIFMTIPSFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGRNPLGDDEASTTASKTETSQVAPA >OPS1_DROME PLS---NGSVVDKVTPDMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNLTSCGID--YLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHMNVRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGKSSDSEAESKA----- >RGR_BOVIN ---------------------MAESGTLPTGFGELEVLAVGTVLLVEALSGLSLNILTILSFCKTPELRTPSHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSEGCQAHGFQGFVTALASICSSAAVAWGRYHHFCTRS---RLDWNTAVSLVFFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLD--YSRGDRNFTSFLFTMAFFNFLLPLFITVVSYRLME--------------QKLGKTSRPPVNTVLPARTLLLGWGPYALLYLYATIADATSISPKLQMVPALIAKAVPTVNAMNYALGSEMVHRGIWQCLSPQRREHSREQ---------------- >VU51_HSV6U ----------------MEKETKSLAWPATAEFYGWVFIFSSIQLCTMVLLTVRFNSFKVGR-E--------YAVFTFAGMSFNCFLLPIKMGLLSGH-----WSLPRDFCAILLYIDDFSIYFSSWSLVFMAIERINHFCYSTLLNENSKALAKVCFPIVWIISGVQALQMLNNYKATA---ETPQCFLA--------FRSGYDMWLMLVYSVMIPVMLVFIYIYSKNFM-----------LLKDELSTVTTYLCIYLLLGTIAHLPKAGLSEIESD----KIFYGLRDIFMALPVLKVYYIPVMAYCMACDDHTVPVRLCSIWLVNLCKKCFSCTLEVGIKMLK--- >A1AA_ORYLA -----------MTPSSVTLNCSNCSHVLAPELNTVKAVVLGMVLGIFILFGVIGNILVILSVVCHRHLQTVTYYFIVNLAVADLLLSSTVLPFSAIFEILDRWVFGRVFCNIWAAVDVLCCTASIMSLCVISVDRYIGVSYPLYPAIMTKRRALLAVMLLWVLSVIISIGPLFGWKEP--AP--TVCKIT--------EEPGYAIFSAVGSFYLPLAIILAMYCRVYVVAQKELRSFALRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVLPIGSIFPAYRPSDTVFKITFWLGYFNSCINPIIYLCSNQEFKKAFQSLLGVHCLRMTPRAHHHHTQGHSLT----- >B1AR_BOVIN VPDGAATAARLLVPASPPASLLTSASEGPPLPSQQWTAGMGLLMAFIVLLIVVGNVLVLVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPIFMQWWGDS-R--ECCDFI--------INEGYAITSSVVSFYVPLCIMAFVYLRVFREAQKQPGRRRPPRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACGSHAAAGCLAVARPSPSPG >OPSH_ASTFA NE--DTTRESAFVYTNANNTRDPFEGPNYHIAPRWVYNVSSLWMIFVVIASVFTNGLVIVATAKFKKLRHPLNWILVNLAIADLGETVLASTISVINQIFGYFILGHPMCVFEGWTVSVCGITALWSLTIISWERWVVVCKPFGNVKFDGKWAAGGIIFSWVWAIIWCTPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVASYMITLMLTCCILPLSIIIICYIFVWSAIHQVAQQQKDSESTQKAEKEVSRMVVVMILAFIVCWGPYASFATFSAVNPGYAWHPLAAAMPAYFAKSATIYNPIIYVFMNRQFRSCIMQLFGKKVEDA-----SEVSTAS-------- >OL15_MOUSE -------------MEVDSNSSSGTFILMGVSDHPHLEIIFFAVILASYLLTLVGNLTIILLSRLDARLHTPMYFFLSNLSSLDLAFTTSSVPQMLKNLWGPDKTISYGGCVTQLYVFLWLGATECILLVVMAFDRYVAVCRPLYMTVMNPRLCWGLAAISWLGGLGNSVIQSTFTLQL---PDNFLCEVPKLACGDTSLNEAVLNGVCTFFTVVPVSVILVSYCFIAQAV--------MKIRSVEGRRKAFNTCVSHLVVVFLFYGSAIYGYLLPAKSS---NQSQGKFISLFYSVVTPMVNPLIYTLRNKEVKGALGRLLGKGRGAS-------------------- >ETBR_HUMAN SLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITRI--LRICLLHQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFE-EKQSLEFKANDHGYDNFR >PE23_MOUSE ---------MASMWAPEHSAEAHSNLS---STTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHYASHMKTRAT-PVLLGVWLSVLAFALLPVLGVG----RYSGTWCFISNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTN-YASSSTSLPCWSDQLER----- >TA2R_MOUSE --MWPNG-----------TSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLTDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLT----LGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQ------------ >ACM3_HUMAN N---------VSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQHKRAPEQAL--- >CCR4_FELCA IYPSDNYTEDDLGSGDYDSMKEPC---FREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVAN--WYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVRE-DG-RYICDRF---YPSDSWLVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGYQKRKALKTTVILILAFFACWLPYYIGISIDSFILLESTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >GPRJ_MOUSE AEAAEALLPHGLMGLHEEHSWMSNRTELQYELNPGEVATASIFFGALWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVVLQFTTGRWTLGSAMCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPL-SFKVSREKAKKMIAASWILDAAFVTPVFFFYG---SNW-HCNYFLP-----PSWEGTAYTVIHFLVGFVIPSILIILFYQKVIKYIWRIDGR-RTMNIVPRTKVKTVKMFLLLNLVFLFSWLPFHVAQLWHPHEQDYKKSSLVFTAVTWVSFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTIKRNYVGISEIPP >AA2B_MOUSE ------------------------------MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLG--FCTDFHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDI-A-PLTCLFE-----NVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQ---MDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQAETKGGSGLSLGL------- >MAS_HUMAN -----MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMR-RNPFTVYITHLSIADISLLFCIFILSIDYALDYESSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIYRCHRPKYQSALVCALLWALSCLVTTMEYVMCI-DRHS--RNDC-----------RAVIIFIAILSFLVFTPLMLVSSTILVVKIRK----------NTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYW--STFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRTVTVETVV---- >TSHR_SHEEP LQAFDNHYDYTVCGGSEEMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNP------HYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGSTGIRVQKVPPD >NK2R_BOVIN ----MGACVVMTDINISSGLDSNATGITAFSMPGWQLALWTAAYLALVLVAVMGNATVIWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPGTRAVIAGIWLVALALAFPQCFYST---GA---TKCVVAWPEDSGGKMLLLYHLIVIALIYFLPLVVMFVAYSVIGLTLWRRGHQHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGTFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----YTPSLSTRVNRC >5H2C_MOUSE LLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAVRSPVHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD-VF--NTTCVL---------NDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQKKKPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKAKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIALSGRELNVNIY >OLF1_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIALISVDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERKTISYVGCILQYFSFVLLTVTESLLLAVMAYDRYVAICKPLYPSIMTKAVCWRLVESLYFLAFLNSLVHTSGLLKL---SNHFFCDISQISSSSIAISELLVIISGSLFVMSSIIIILISYVFIILTV--------VMIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRLTATTFGFIDSKAVQ-------------- >O.2R_RAT ASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL-MFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSKTTLFTVCDER---WGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRKARVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLG-VHRRQGDRLESRKSLTTQISN >CKR8_MOUSE DYTMEPNVTMT--DYYPDFFTAPC---DAEFLLRGSMLYLAILYCVLFVLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQ--WVFGTAMCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVAIKVRTASVGTALSLTVWLAAVTATIPLMVFYQVAS-ED-MLQCFQF-YEEQSLRWKLFTHFEINALGLLLPFAILLFCYVRILQQL---------RGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHQRLALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKS-CSHIFLYLGRQRQ------LSSN >GPRF_MACNE ----MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPLKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTSKLLAIVSGLQAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFT >MC3R_MOUSE NSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALYHSIMTVRKALTLIGVIWVCCGICGVMFIIYYS----------------------EESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHIAVAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG------------------ >CCR5_RAT DDLYKELAIYSNSTEIPLQDSIFCSTEEGPLLTSFKTIFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLLVFILPFAVAEGSVG--WVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAVAYRRRRLLSIHITCSTIWLAGFLFALPELLFAKVVQ-NE-LPQCIFSQENEAETRAWFASRFLYHTGGFLLPMLVMAWCYVGVVHRL--------LQAQRRPQRQKAVRVAILVTSIFLLCWSPYHIVIFLDTLERLKGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCAG---PASLC--------PGWR >OPSD_LOLFO ---MGRDIPDNETWWYNPYMDIHPHWKQFDQVPAAVYYSLGIFIAICGIIGCVGNGVVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFMKWVFGNAACKVYGLIGGIFGLMSIMTMTMISIDRYNVIGRPMASKKMSHRKAFIMIIFVWIWSTIWAIGPIFGWGAYTLEGVLCNCSFD--YITRDTTTRSNILCMYIFAFMCPIVVIFFCYFNIVMSVSNHRLNLRKAQAGANAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFRERIASNFPWILTCCQYDEKEIEEIPAGEQS-GGE >OPSD_TODPA ----GRDLRDNETWWYNPSIVVHPHWREFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKWIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLEGVLCNCSFD--YISRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHRLNLRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQFDDKETEEIPAGESSDAAP >OPRK_RAT LPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVDVD-VIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVASMRDVGGMNKP >ACM4_RAT ------M-NFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-VP-DNQCFIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR---------------- >SSR3_RAT SVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPR-----STCHMQ-WPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTSCQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGEEDEEEEERREE >OPSD_HUMAN MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA >OPSG_GECGE RDDDDTTRGSVFTYTNTNNTRGPFEGPNYHIAPRWVYNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDLVETLVASTISVFNQIFGYFILGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVVCKPFGNIKFDSKLAIIGIVFSWVWAWGWSAPPIFGWSRYWPHGLKTSCGPDVFSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIRAVAAQQKESESTQKAEREVSRMVVVMIVAFCICWGPYASFVSFAAANPGYAFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIMQLFGKKVDDG-----SEAVSSVSNSSVAPA >OAR_BOMMO TEIYDVIEDEKDVCAVADEPNIPCSFGISLAVPEWEAICTAIILTMIIISTVVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPIYAQKRTLERVLFMIGIVWILSLVISSPPLLGWNDW-E-P--TPCRLT--------SQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRAVYEEKQRISLTRERRAARTLGIIMGVFVVCWLPFFVIYLVIPFCVSCCLSNKFINFITWLGYVNSALNPLIYTIFNMDFRRAFKKLLFIKC----------------------- >YQH2_CAEEL EQSTPARENLPNREIYQIFQFTLVYALPLSNHDNSSLMLIAGFYALLFMFGTCGNAAILAVVHHVKGRHNTTLTYICILSIVDFLSMLPIPMTIIDQILGF-WMFDTFACKLFRLLEHIGKIFSTFILVAFSIDRYCAVCHPLQVRVRNQRTVFVFLGIMFFVTCVMLSPILLYAHSKVTRMHLYKCVDD----LGRELFVVFTLYSFVLAYLMPLLFMIYFYYEMLIRLFKQLVGGGEEKKLTIPVGHIAIYTLAICSFHFICWTPYWISILYSLYEELYYAFIYFMYGVHALPYINSASNFILYGLLNRQLHNAPERKYTRNGVGGRQMSHALTSELIAIPSSSCR >UL33_HSV7J ----MICYSFAKNVTFAFLIILQNFFSQHDEEYKYNYTCITPTVRKAQRLESVINGIMLTLILPVSTKQTITSPYLITLFISDSLHSLTVLLLTLNREAL--TNLNQALCQCVLFVYSASCTYSLCMLAVISTIRYR-TLQRRTLNDKNNNHIKRNVGILFLSSAMCAIPAVLYVQVEKK-KNYGKCNIHSTQKAY-DLFIGIKIVYCFLWGIFPTVIFSYFYVIFGKTL---------RALTQSKHNKTLSFISLLILSFLCIQIPNLLVMSVEIFFLYIIQREIVQIISRLMPEIHCLSNPLVYAFTRTDFRLRFYDFIKCNLCNSSLKRKRNP------------ >C5AR_RAT DPISNDSSEITYDYSDGTPNPDMPADGVYIPKMEPGDIAALIIYLAVFLVGVTGNALVVWVTAFEAK-RTVNAIWFLNLAVADLLSCLALPILFTSIVKHNHWPFGDQACIVLPSLILLNMYSSILLLATISADRFLLVFKPICQKFRRPGLAWMACGVTWVLALLLTIPSFVFRRIHK-SD--ILCNID-YSKGPFFIEKAIAILRLMVGFVLPLLTLNICYTFLLIRT---------WSRKATRSTKTLKVVMAVVTCFFVFWLPYQVTGVILAWLPRSQSVERLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLRRSLPSIIRNVLSEDSLGRSTMD-------- >CKR6_HUMAN DSSEDYFVSVNTSYYSVDSEMLLC---SLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGA-WVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYN-TQ-SDVCEPKQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTL---------VQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFEN------ISRQ >B2AR_MOUSE MGPHGNDSDFLLAPNGSRAPDH----DVTQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-D--TCCDFF--------TNQAYAIASSIVSFYVPLCVMVFVYSRVFQVAKRQGRSLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRDNL-IPKEVYILLNWLGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSSKTYGNGYSDYTGEPNTCQLG >DADR_DIDMA ---------------MPLNDTTMDRRGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLNWHKAGN-TMDNCDSS--------LSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCESDCIDSITFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPTANNAIETGAVFSSH----- >O.YR_MACMU GELAANWSTEAVNSSAAPPGAEGNCTAGPPRRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNRMAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANA-KEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGNRLGENSSSFVLSHRSS >AG2R_MELGA ------MVPNYSTEETVKRIHVDC---PVSGRHSYIYIMVPTVYSIIFIIGIFGNSLVVIVIYCYMKLKTVASIFLLNLALADLCFLITLPLWAAYTAMEYQWPFGNCLCKLASAGISFNLYASVFLLTCLSIDRYLAIVHPVSRIRRTMFVARVTCIVIWLLAGVASLPVIIHRNIFF-LN--TVCGFR-YDNNNTTLRVGLGLSKNLLGFLIPFLIILTSYTLIWKTLKKA----YQIQRNKTRNDDIFKMIVAIVFFFFFSWIPHQVFTFLDVLIQLHDIVDTAMPFTICIAYFNNCLNPFFYVFFGKNFKKYFLQLIKYIPPNVSTHPSLTTRPPE-------N >TSHR_MOUSE LQAFESHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSY----KVSICLPM-----TDTPLALAYIVLVLLLNVVAFVVVCSCYVKIYITVRNP------QYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYQGSTGIQIQKIPQD >CCR3_MOUSE FAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQ--WVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATIYRRDPRVRVALTCIVVWGLCLLFALPDFIYLSANY-RL-ATHCQYN----FPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVL---------LVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGSHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREKMWMLFTRLGRSDQRGPQRQPSWSETTEASYLG >AA2B_RAT ------------------------------MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLG--FCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDI-T-PVKCLFE-----NVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQ---MEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGFSLSL------- >MSHR_RANTA PVLGSQRRLLGSLNCTPPATFPLMLAPNRTGPQCLEVSIPNGLFLSLGLVSLVENVLVVAAIAKNSNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHRGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >CKR3_RAT EEELKTVVETFETTPYEYEWAPPC---EKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNE-WGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVALRARTVTFATITSIITWGFAVLAALPEFIFHESQD-NF-DLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTL---------LRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLT-------SSVS >OPS2_HEMSA DFGYPEGVSIVDFVRPEIKPYVHQHWYNYPPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLIMLTTNVPFFTYNCFSGGWMFSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNGPKLTTGKAVVFALISWVIAIGCALPPFFGWGNYILEGILDSCSYD--YLTQDFNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHMNVRSNEADAQRAEIRIAKTALVNVSLWFICWTPYALISLKGVMGDTSGITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAITQHLPWFCVHETETKSNDDAQDKA------- >AG2R_RABIT ------MMLNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTRPSD-------N >5H2A_HUMAN NTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILAYKSSQLQMGQK >AA2A_HUMAN -------------------------------MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGS-Q-QVACLFE-----DVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQESQGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGAHGSDGEQVSLR >HH2R_CAVPO -------------------MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLITPARVAISLVFIWVISITLSFLSIHLGWN--RN-TIVKCKVQ--------VNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQR--IGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDD-VNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRRSQCQEPRW--- >IL8B_HUMAN KGEDLSNYSYSSTLPPFLLDAAPC----EPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVY-NV-SPACYED-MGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDS------------ >OLF5_RAT -------------MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILAIGTDSRLHTPMYFFLSNLSFVDVCFSSTTVPKVLANHILGSQAISFSGCLTQLYFLAVFGNMDNFLLAVMSYDRFVAICHPLYTTKMTRQLCVLLVVGSWVVANMNCLLHILLMARL---SPHFFCDGTKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITCAV--------LRVSSPRGGWKSFSTCGSHLAVVCLFYGTVIAVYFNPSSSH---LAGRDMAAAVMYAVVTPMLNPFIYSLRNSDMKAALRKVLAMRFPSKQ------------------- >OPSB_CHICK TDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSRYIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRAVARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQFRSCMLKLLFCGRSPFGDDEDVSGSSVSSSHVAPA- >AA2A_RAT ----------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCST-K-RVTCLFE-----DVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQESQGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGAHSTEGEQVSLR >OLF6_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIALISIDLQLQTPMYIFLQNLSFTDAVYSTVITPKMLATFLEETKTISYVGCILQYFSFVLLTVRECLLLAVMAYDRYAAICKPLYPAIMTKAVCWRLVKGLYSLAFLNFLVHTSGLLKL---SNHFFCDNSQISSSSTALNELLVFIFGSLFVMSSIITILISYVFIILTV--------VRIRSKERKYKAFSTCTSHLMAVSLFHGTIVFMYFQPANNF---SLDKDKIMSLFYTVVIPMLNPLIYSWRNKEVKDALHRAIATAVLFH-------------------- >P2Y6_HUMAN -----------MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATG-----RTVCYDL-SPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQ---GPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR--------------- >OPS5_DROME SLGDGSVFPMGHGYPAEYQHMVHAHWRGFREAPIYYHAGFYIAFIVLMLSSIFGNGLVIWIFSTSKSLRTPSNLLILNLAIFDLFMCTN-MPHYLINATVGYIVGGDLGCDIYALNGGISGMGASITNAFIAFDRYKTISNPI-DGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYPEGFLTTCSFD--YLTNTDENRLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHNVKANANADNMSVELRIAKAALIIYMLFILAWTPYSVVALIGCFGEQQLITPFVSMLPCLACKSVSCLDPWVYATSHPKYRLELERRLPWLGIREKHATSGTSSVSGDTLALSVQ >YR13_CAEEL --------------------MSNIFSVPLDPMSVAVGIPYVCFFIILSVVGIIGNVIVIYAIAGDRNRKSVMNILLLNLAVADLANLIFTIPEWIPPVFFGSWLFPSFLCPVCRYLECVFLFASISTQMIVCIERYIAIVLPMARQLCSRRNVLITVLVDWIFVACFASPYAVWHSVK-LFQLSATCSNT---VGKSTWWQGYKLTEFLAFYFVPCFIITVVYTKVAKCLWCKCLDSSRSSDALRTRRNVVKMLIACVAVYFVCYSPIQVIFLSKAVLNVTHPPYDFILLMNALAMTCSASNPLLYTLFSQKFRRRLRDVLYCPSDVENETKTYYSGPRASF------ >5H1B_CRIGR CAPPPPAASQTGVPLVNLSHNSAESHIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPVSTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYAAKRTPKRAAIMIALVWVFSISISLPPFFWR----E-E--LTCLVN-------TDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMATLDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG--------------------- >D2DR_BOVIN ---MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC------------------------- >VU51_HSV6Z ----------------MEKETKSLAWPATAEFYGWVFIFSSIQLCTVVFLTVRFNGFKVGR-E--------YAVFTFAGMSFNCFLLPIKMGLLSGH-----WTLPRDFCAILLYIDDFSAYFSSWSLVFMAIERINYFCYSTLLNENSKALAKVCFPIVWVVSGVQALQMLNNYKATA---ETGQCFLA--------FRSGHDMWLMLVYSVVIPVMLVFFYLYSKNFM-----------LLKDELSSVTTYLCIYLLLGTIAHLPKAALSEIESD----KIFYGLRDIFMALPVLKVYYISAMAYCMACDDHTVPVRLCSIWLVNLCKKCFSCTLEVGIKMLK--- >D2DR_MOUSE ---MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC------------------------- >CCR4_MACFA IYTSDNYTEEMG-SGDYDSIKEPC---FREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLYVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALGFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >HH1R_BOVIN ---------MTCPNSSCVFEDKMCQGNKTAPANDAQLTPLVVVLSTISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGVVVMPMNILYLLMSRWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASITILAAWFLSFLWIIPILGWRHFQ--EP-EDKCETD------FYNVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHLRSQYVSGLHMNRERKAAKQLGFIMAAFIICWIPYFIFFMVIAFCESC-CNQHVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS----------------------- >OPS2_DROPS AQTG-GNRSVLDNVLPDMAPLVNPHWSRFAPMDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKIAFIWMMAVFWTIMPLIGWSSYVPEGNLTACSID--YMTRQWNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHMNVRSSEDCDKSAENKLAKVALTTISLWFMAWTPYLIICYFGLFKIDG-LTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLKEKCPMCVCGTTDEPKPDATSEAESKD---- >OPSD_SCYCA MNGTEGENFYIPMSNKTGVVRSPFDYPQYYLAEPWKFSVLAAYMFFLIIAGFPVNFLTLYVTIQHKKLRQPLNYILLNLAVADLFMIFGGFPSTMITSMNGYFVFGPSGCNFEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGSQHAFMGVGLTWIMAMACAFPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFSIPLTIIFFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVIIMVIAFLICWLPYASVAFFIFCNQGSEFGPIFMTIPAFFAKAASLYNPLIYILMNKQFRNCMITTICCGKNPFEEEESTSASSVSSSQVAPAA >OPSD_BUFBU MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSILCAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTVTMYSSMNGYFILGATGCYVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFSENHAVMGVAFTWIMALSCAVPPLLGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVFFLICWVPYASVAFFIFSNQGSEFGPIFMTVPAFFAKSSSIYNPVIYIMLNKQFRNCMITTLCCGKNPFGEDDASSAASSVSSSQVSPA >ACM4_CHICK AQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIV-VH-ERECYIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETC-VPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR---------------- >GRHR_RAT --MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPL-AVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYAV--FSQCVTH--SFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVPRKNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >C5AR_MOUSE ---MNSSFEINYDHY-GTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFEPD-GPSNAIWFLNLAVADLLSCLAMPVLFTTVLNHNYWYFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPICQKVRGTGLAWMACGVAWVLALLLTIPSFVYREAYK-SE--TVCGIN-YGGGSFPKEKAVAILRLMVGFVLPLLTLNICYTFLLLRT---------WSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSKRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRSTDD-------- >5H2A_MACMU NTSDAFNWTVESENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEDPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILAYKSSQLQMGQK >LSHR_BOVIN ESELSGWDYDYGFCLPKTLQCAPEPDAFNPCEDIMGYNFLRVLIWLINILAITGNVTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGWQTG-SGCSAAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLKHAIPVMLGGWLFSTLIAVLPLVGVSNY----KVSICLPM-----VESTLSQVYILTILILNVMAFIIICACYIKIYFAVQNP------ELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFQRDFFLLLSKFGCCKYRAELYRRSNCKNGFTGSNK >SSR5_HUMAN LFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASF-WPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQE-----GTCNAS-WPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGV--RVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEQQQEATRPRTAA >B2AR_PIG MGQPGNRSVFLLAPNGSHAPDQ----DVPQERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGSFWCEFWISIDVLCVTASIETLCVIAVDRYLAITSPFYQCLLTKNKARVVILMVWVVSGLISFLPIKMHWYQAL-N--ACCDFF--------TNQPYAIASSIVSFYLPLVVMVFVYSRVFQVARRQGRSHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHGIHDNL-IPKEVYILLNWVGYVNSAFNPLIYCRSP-DFRMAFQELLCLHRSSLKAYGNGCSDYTGEQSGCYLG >FSHR_RAT SDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNP------TIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTNFHARKSHCSSA >D4DR_MOUSE ---MGNSSATEDGGLLAGRGP---ESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPL-RYNQQGQCQLLLIAATWLLSAAVASPVVCGLN---G-R--AVCCL---------ENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWPEPRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC----------------------- >GALT_MOUSE --------------------MADIQNISLDSPGSVGAVAVPVVFALIFLLGMVGNGLVLAVLLQPGPPGSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLSRALRTPRNARAAVGLVWLLAALFSAPYLSYYG---GA--LELCVPA----WEDARRRALDVATFAAGYLLPVTVVSLAYGRTLCFLWAAGP-AAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAPATYACRLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGHRRHRHHHHRLHPASSGPAGYPGD >AG2R_RAT ------MALNSSAEDGIKRIQDDC---PKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYF-TN--TVCAFH-YESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------N >NMBR_RAT PNLSLPTEASESELEPEVWENDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARSS--FTACIPY---QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSLPGNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKELGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGQKSYPERSTSYLMTSLKSNAKNVV >NY1R_CANFA TSFSQVENHSIFCNFSE-NSQFLAFESDDCHLPLAMIFTLALAYGAVIILGVTGNLALIMIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYVGIAVIWVLAVVSSLPFLIYQVLTDKD--KYVCFDK---FPSDSHRLSYTTLLLMLQYFGPLCFIFICYFKIYIRLKRRNMMMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >A2AD_HUMAN AAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ----------------- >V1AR_SHEEP SSRWWPLDAGDANTSGDLAGLGEDGGPQADTRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLGWDITYRFRGPDGLCRVVKHMQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMVETK--TYDCWAN---FIHPWGLPAYVTWMTGSVFVAPVVILGTCYGFICYHIWRKVLHVSSVKTISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSAWDKNFESENPATAIPALLASLNSCCNPWIYMFFSGHLLQDCAQSFPCCQNVKRTFTREGSTSFTNNRSPTNS >FML1_MOUSE -----------MESNYSIHLNGSEVVVYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMP-HTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRVSWVEERLNTA------ITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKI---------HKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHIAS---------- >OPSD_PETMA MNGTEGENFYIPFSNKTGLARSPFEYPQYYLAEPWKYSVLAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLGGEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWSRYLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKEAAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQFRNCMITTLCCGKNPLGDEDSGASVSSVSTSQVSPA >B2AR_MACMU MGQPGNGSAFLLAPNGSHAPDH----DVTQERDEAWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQGRTLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWVGYVNSGFNPLIYCRSP-DFRIAFQELLCLRRSSLKACGNGYSGNTGEQSGYHLE >AG2R_SHEEP ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFIMIPTLYSIIFVVGLFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASGSVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFHVYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKA----YEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGDIVDTAMPITICLAYFNNCLNPPFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTRPSE-------N >AG2R_BOVIN ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFH-YESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKA----YEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTRPSE-------N >ACM2_HUMAN --------------MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VE-DGECYIQ------FFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >PF2R_HUMAN --MSMNN---------SKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYN--TEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELKVAAISESPVA >US28_HCMVA ----MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDH--NSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMR---YRPVKQACLFSIFWWIFAVIIAIPHFMVVTKK-----DNQCMTD-YDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIV---------AVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKRSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYRSSPSRRETSSD >NK4R_HUMAN NLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHE-WYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATRIVIGSIWILAFLLAFPQCLYSK---GR---TLCYVQ--WPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGG--PCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSY----ATRLHPMRQSSL >MC3R_RAT NSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLLSLLQADMLVSLSNSLETIMIVVINSDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALYHSIMTVRKALSLIVAIWVCCGICGVMFIVYYS----------------------EESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHIAAADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG------------------ >OPS1_HEMSA TFGYPEGMTVADFVPDRVKHMVLDHWYNYPPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIMLTTNFPPFCYNCFSGGWMFSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNGPKLTQGKATFMCGLAWVISVGWSLPPFFGWGSYTLEGILDSCSYD--YFTRDMNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHMNVRSNEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLLGNAEGITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLPWFCVHEKDPNDVEETQEKS------- >AA3R_RAT -----------------------MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLE--VQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWN-RKE-L-TLSCHFR-----SVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNK--NFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVK--IPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSN------------ >SSR4_RAT GED----TTWTPGINASWAPDEEEDAVRSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPGGE-AVACNLH---WPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR-AGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEETALKSRGGPGCI >NK1R_RAT -----MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQGYYST---SR---VVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAS-IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY----STRYLQTQSSVY >OPSD_SARDI MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAILGAYMFFLIIVGFPVNFMTLYVTLEHKKLRTPLNYILLNLAVADLFMVIGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGMISLWSLAVLAIERWVVVCKPISNFRFGENHAIMGVSLTWGMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFFCHFTIPLTIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLVCWLPYASVAWFIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLFCGKNPF---EGEEETEASSASSVSPA >FSHR_HORSE FDMMYSEFEYDLCNEVVDVTCSPKPDAFNPCEDIMGYDILRVLIWFISILAITGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVQLRHAASVMLVGWIFAFAVALLPIFGISTY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNP------NIVSSSSDTKIAKRMAILIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQLYRTISHPRNGHCPPT >OPSG_CARAU MNGTEGKNFYVPMSNRTGLVRSPFEYPQYYLAEPWQFKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSSSHAFAGIAFTWVMALACAAPPLFGWSRYIPEGMQCSCGPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSASTQKAEREVTKMVILMVFGFLIAWTPYATVAAWIFFNKGADFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIFCGKNPLGDDESS--TSKTEVSSVSPA >AA3R_RABIT ------------------------MPDNSTTLFLAIRASYIVFEIVIGVCAVVGNVLVIWVIKLNPSLKTTTFYFIFSLALADIAVGFLVMPLAIVISLG--ITIGFYSCLVMSCLLLVFTHASIMSLLAIAVDRYLRVKLTVYRRVTTQRRIWLALGLCWVVSLLVGFTPMFGWN-MKE-S-DFQCKFD-----SVIPMEYMVFFSFFTWILIPLLLMCALYVYIFYIIRNK--SFKETGAFYRREFKTAKSLFLVLALFAGCWLPLSIINCVTYFKCK--VPDVVLLVGILLSHANSMMNPIVYACKIQKFKETYLLIFKARVTCQPSDSLDPS------------ >5H1D_HUMAN SPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAATMIAIVWAISICISIPPLFWR----Q-E--SDCLVN-------TSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRKLALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS--------------------- >CCR4_MACMU IYTSDNYTEEMG-SGDYDSIKEPC---FREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQKPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIDILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >OPSP_CHICK ------MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGDFQFQRRHAVSGCAFTWGWALLWSAPPLLGWSSYVPEGLRTSCGPN--WYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEMLCCGYQPQRTGKASPGVTAAGLRNKVMP >O7C1_HUMAN -------------METGNQTHAQEFLLLGFSATSEIQFILFGLFLSMYLVTFTGNLLIILAICSDSHLHTPMYFFLSNLSFADLCFTSTTVPKMLLNILTQNKFITYAGCLSQIFFFTSFGCLDNLLLTVMAYDRFVAVCHPLYTVIMNPQLCGLLVLGSWCISVMGSLLETLTVLRL---SPHFFCDLLKLACSDTFINNVVIYFATGVLGVISFTGIFFSYYKIVFSI--------LRISSAGRKHKAFSTCGSHLSVVTLFYGTGFGVYLSSAATP---SSRTSLVASVMYTMVTPMLNPFIYSLRNTDMKRALGRLLSRATFFNGDITAGLS------------ >OPR._PIG GSPLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTAVLLTLPFQGTDVLLGF-WPFGNALCKAVIAIDYYNMFTSAFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASIVGVPVAIMGSAQVEE---IECLVE-IPAPQDYWGPVFAVCIFLFSFVIPVLIISVCYSLMVRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETAVAVLRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCAPTRRREMQVSDRVALACKTSETVPR >OPSD_RAT MNGTEGPNFYVPFSNITGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLCCGKNPLGDDEASATASKTETSQVAPA >P2UR_HUMAN ----MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVLGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTS-----RVTCHDT-SAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKP---YGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLTDMQRIGDVLGS >D1DR_OREMO -MEIFTTTRGTSAGPEPAPGGHGGTDSPR-TSDLSLRALTGCVLCILIVSTLLGNALVCAAVIKFRHRSKVTNAFVISLAVSDLFVAVLVMPWRAVSEVAGVWLFG-AFCDTWVAFDIMCSTASILHLCIISMDRYWAISSPFYERRMTPRFGCVMIGVAWTLSVLISFIPVQLNWHARR--DPGDCNAS--------LNRTYAISSSLISFYIPVLIMVGTYTRIFRIGRTQPALESSLKTSFRRETKVLKTLSVIMGVFVFCWLPFFVLNCMVPFCRLECVSDTTFSVFVWFGWANSSLNPVIYAFNA-DFRKAFSTILGCSRYCRTSAVEAVDYHHDTTLQK--- >OPSP_PETMA HHSLPSALPSATGGNGTVATMHNPFERPLEGIAPWNFTMLAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYFGVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWSSYRPSMIGTTCEPN--WYSGELHDHTFILMFFSTCFIFPLAVIFFSYGKLIQKLKKASETQRGLESTRRAEQQVTRMVVVMILAFLVCWMPYATFSIVVTACPTI---PLLAAVPAFFSKTATVYNPVIYIFMNKQFRDCFVQVLPCKGLKKVSATQTAGASVNTQSPGNRH >DADR_RAT ---------------MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLG-PFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-EDDNCDTR--------LSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSECIDSITFDVFVWFGWANSSLNPIIYAFNA-DFQKAFSTLLGCYRLCPTTNNAIETAVVFSSH----- >GALS_RAT ------------MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLSRELRTPRNALAAIGLIWGLALLFSGPYLSYYR---AN--LTVCHPA----WSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTDP-VTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVHSGSMLEQESTD >5H7_MOUSE SSWMPHLLSGFPEVTASPAPTNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKNVRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMAKMILSVWPLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSSRLERKNISSFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTCLWLGYANSLINPFIYSFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERSEFVLQ >EBI2_HUMAN ------MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMS--KQEERITCMEY--NFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAK-QNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAMTETQMMIHSKS >TSHR_CANFA LQAFDSHYDYTVCGGNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLIVLLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHAYAIMVGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIILVLLLNIVAFIIVCSCYVKIYITVRNP------QYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGSAGIQIQKVTRD >NY4R_RAT HLMASLSPAFLQGKNGTNPLDSLYNLSDGCQDSADLLAFIITTYSVETVLGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPT-GWKPSISQAYLGIVVIWFISCFLSLPFLANSILNDED--KVVCFVS---WSSDHHRLIYTTFLLLFQYCVPLAFILVCYMRIYQRLQRQRA-THTCSSRVGQMKRINGMLMAMVTAFAVLWLPLHVFNTLEDWYQEACHGNLIFLMCHLFAMASTCVNPFIYGFLNINFKKDIKALVLTCRCRPPQGEP---TVHTDLSKGSMR >CKR5_PAPHA ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OLF2_RAT ------------MESGNSTRRFSSFFLLGFTENPQLHFLIFALFLSMYLVTVLGNLLIIMAIITQSHLHTPMYFFLANLSFVDICFTSTTIPKMLVNIYTQSKSITYEDCISQMCVFLVFAELGNFLLAVMAYDRYVA-CHPLYTVIVNHRLCILLLLLSWVISIFHAFIQSLIVLQL---TPHFFCELNQLTCSDNFPSHLIMNLVPVMLAAISFSGILYSYFKIVSSI--------HSISTVQGKYKAFSTCASHLSIVSLFYSTGLGVYVSSAVVQ---SSHSAASASVMYTVVTPMLNPFIYSLRNKDVKRALERLLEGNCKVHHWTG---------------- >HH2R_HUMAN -------------------MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWN--RN-TTSKCKVQ--------VNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQR--ISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDD-INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRRTQSREPRQ--- >CKR5_HYLLE ----MDYQVSSPTYDIDYDTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILVLINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKHFCKCCSIFA-------SSVY >B3AR_HUMAN MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVQ-R--RCCAFA--------SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPS-VPGPAFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCGRRLPPEPCAAAGVPAARSSPAQP >NY6R_MOUSE --MEVLTNQPTPNKTSGKSNNSAFFYFESCQPPFLAILLLLIAYTVILIMGIFGNLSLIIIIFKKQRAQNVTNILIANLSLSDILVCVMCIPFTVIYTLMDHWVFGNTMCKLTSYVQSVSVSVSIFSLVLIAIERYQLIVNPR-GWKPRVAHAYWGIILIWLISLTLSIPLFLSYHLTNTH--QVACVEI---WPSKLNQLLFSTSLFMLQYFVPLGFILICYLKIVLCLRKRTRQRKENKSRLNENKRVNVMLISIVVTFGACWLPLNIFNVIFDWYHEMCHHDLVFVVCHLIAMVSTCINPLFYGFLNKNFQKDLMMLIHHCWCGEPQESY---TMHTDESKGSLK >OLF4_RAT -------------MTGNNQTLILEFLLLGLPIPSEYHLLFYALFLAMYLTIILGNLLIIVLVRLDSHLHMPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSISYTGCLTQLYFFMVFGDMESFLLVVMAYDRYVAICFPLYTTIMSTKFCASLVLLLWMLTMTHALLHTLLIARL---SLHFFCDISKLSCSDIYVNELMIYILGGLIIIIPFLLIVMSYVRIFFSI--------LKFPSIQDIYKVFSTCGSHLSVVTLFYGTIFGIYLCPSGNN---STVKEIAMAMMYTVVTPMLNPFIYSLRNRDMKRALIRVICTKKISL-------------------- >OPSD_ZEUFA MNGTEGPDFYVPMVNTTGIVRSPYDYPQYYLVNPAAFSMLAAYMFFLILVGFPVNFLTLYVTMEHKKLRTPLNYILLNLAVANLFMVIGGFTTTMYTSMHGYFVLGRTGCNLEGFFATLGGEIALWSLVVLAVERWVVVCKPISNFRFGENHAVMGVSFTWLMACACSVPPLFGWSRYIPEGMQCSCGIDYYTRAPGYNNESFVIYMFVCHFSIPLTIIFFCYGRLLCAVKDAAAAQQESETTQRAEREVSRMVVIMVIGFLICWLPYASVAWFIFTHQGSEFGPVFMTIPAFFAKSSAIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSHVSPA >OPSD_CYPCA MNGTEGPMFYVPMSNATGVVKSPYDYPQYYLVAPWAYGCLAAYMFFLIITGFPINFLTLYVTIEHKKLRTPLNYILLNLAISDLFMVFGGFTTTMYTSLHGYFVFGRIGCNLEGFFATLGGEMGLWSLVVLAFERWMVVCKPVSNFRFGENHAIMGVVFTWFMACTCAVPPLVGWSRYIPEGMQCSCGVDYYTRAPGYNNESFVIYMFLVHFIIPLIVIFFCYGRLVCTVKDAAAQQQESETTQRAEREVTRMVVIMVIGFLICWIPYASVAWYIFTHQGSEFGPVFMTVPAFFAKSAAVYNPCIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >A2AR_LABOS -----MDPLNATGMDAFTAIHLNASWSADSGYSLAAIASIAALVSFLILFTVVGNILVVIAVLTSRALKAPQNLFLVSLATADILVATLVMPFSLANELMGYWYFGKVWCGIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPKRVKCIIVIVWLISAFISSPPLLSIDS--I-S--PQCMLN--------DDTWYILSSSMASFFAPCLIMILVYIRIYQVAKTRKRRIAEKKVSQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLHAVCRDYKIPDTLFK-FFWIGYCNSSLNPAIYTIFNRDFRRAFQKILCKSWKKSF------------------- >D3DR_HUMAN --------MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN---D-P--TVCSI---------SNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRTSLPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------- >D2DR_FUGRU -----MDVFTQYAYNDSIFDNGTWSANETTKDETHPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSRRRVTVMISVVWVLSFAISCPLLFGLN---T-R--SLCFI---------ANPAFVVYSSIVSFYVPFIVTLLVYVQIYVVLRKRQTSLSKRKISQQKEKKATQMLAIVLGVFIICWLPFFITHILNTHCTRCKVPAEMYNAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKILHC------------------------- >P2Y4_HUMAN ASTESSLLRSLGLSPGPGS---SEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTS-----TVLCHDT-TRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQP----LPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLASSCRWAATPQDS >GALR_MOUSE ----MELAMVNLSEGNGSDPEPPAPESRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRSSSLRVSRNALLGVGFIWALSIAMASPVAYHQRLF-SN--QTFCWEQ---WPNKLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLK--NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVVHLWAEFGAFPPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHVCDESPRSETKEPPSTNCTHV--- >OAR1_LOCMI SSAAEEPQDALVGGDACGGRRPPSVLGVRLAVPEWEVAVTAVSLSLIILITIVGNVLVVLSVFTYKPLRIVQNFFIVSLAVADLTVAVLVMPFNVAYSLIQRWVFGIVVCKMWLTCDVLCCTASILNLCAIALDRYWAITDPIYAQKRTLRRVLAMIAGVWLLSGVISSPPLIGWNDW-N-D--TPCQLT--------EEQGYVIYSSLGSFFIPLFIMTIVYVEIFIATKRRPVYEEKQRISLSKERRAARTLGIIMGVFVVCWLPFFLMYVIVPFCNPSKPSPKLVNFITWLGYINSALNPIIYTIFNLDFRRAFKKLLHFKT----------------------- >ML1A_SHEEP GSPGGTPKGNGSSALLNVSQAAPGAGDGVRPRPSWLAATLASILIFTIVVDIVGNLLVVLSVYRNKKLRNAGNVFVVSLAVADLLVAVYPYPLALASIVNNGWSLSSLHCQLSGFLMGLSVIGSVFSITGIAINRYCCICHSLYGKLYSGTNSLCYVFLIWTLTLVAIVPNLCVGT-LQYDP-IYSCTFT------QSVSSAYTIAVVVFHFIVPMLVVVFCYLRIWALVLQVWK-PDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLVVASDPASRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRQEYRKIIVSLCTTKMFFVDSSNRKPSPLIANHNL >OPSD_SOLSO MNGTEGPYFYIPMLNTTGIVRSPYEYPQYYLVNPAAYAALCAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAVERWMVVCKPISNFRFTENHAIMGLGFTWFAASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLICWCPYAGVAWYIFSNQGSEFGPLFMTIPAFFAKSSSIYNPLIYIFMNKQFRHCMITTLCCGKNPFEEEEGSTTSASSSSVSPAA- >ML1A_MOUSE -------MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLHCQVSAFLMGLSVIGSIFNITGIAMNRYCYICHSLYDKIYSNKNSLCYVFLIWMLTLIAIMPNLQTGT-LQYDP-IYSCTFT------QSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVLQVRR-PDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNLIGLIVASDPATRIPEWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKKIIVSLCTAKMFFVESSNCKPSPLIPNNNL >OPSD_POERE MNGTEGPYFYVPMVNTTGIVRSPYEYPQYYLVSPAAYACLGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNLEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFSENHAIMGLVFTWIMANSCAAPPLLGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFICHFCIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIGFLVCWIPYASVAWYIFTHQGSEFGPLFMTVPAFFAKSASIYNPLIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >PE22_HUMAN ----------------MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQLAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYYQRRVSASGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIR--------HGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMGGPRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSS---RKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSSKQADL------ >CKR3_HUMAN MTTSLDTVETFGTTSYYDDVGLLC---EKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEE-LF-ETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLT-------SSVS >GPRA_HUMAN TPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVPRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPL--RRASRCASAYAVLAIWALSAVLALPPAVHTYHVEHD--VRLCEEF--WGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRPGC-SQADWDRARRRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPHAYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMT------------ >OPSD_LIZAU MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILIGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAVERWMVVCKPISNFRFGEDHAIMGLAFTWVMAAACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLVCWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRQCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >PF2R_BOVIN --MSTNS---------SIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYK--TDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELKVAAISDLPVT >GALR_RAT ----MELAPVNLSEGNGSDPEPP-AEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLF-SN--QTFCWEH---WPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLK--NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEPPSTNCTHV--- >OPSU_BRARE MNGTEGPAFYVPMSNATGVVRSPYEYPQYYLVAPWAYGFVAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLGGEMGLKSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWSRYIPEGMQCSCGVDYYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTVKEAARQQQESETTQRAEREVTRMVIIMVIAFLICWLPYAGVAWYIFTHQGSEFGPVFMTLPAFFAKTSAVYNPCIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >GPR6_RAT GPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAG-CGLILHFVFQ-Y--VVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCL-A--DRASCSVV-------RPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHIALHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQ----EDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSP------------ >ACM3_CHICK DSPETTESFPFSTVETTNSSLNATIKDPLGGHAVWQVVLIAFLTGIIALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMGHWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWIISFVLWAPAILFWQYFV-VP-LDECFIQ------FLSEPIITFGTAIAAFYLPVTIMSILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILFAFIITWTPYNIMVLVNTFCDC--VPKTVWNLGYWLCYINSTVNPVCYALCNKMFRNTFKMLLLCQCDKRKRRKQQYQHKRIPREAS--- >NY5R_CANFA -------------NTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMRKRNQKTMVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVESS--RYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGVHDNRSIMRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLISLIQCLHMS--------------------- >MC5R_SHEEP -MNSSFHLHFLDLGLNATEGNLSGLSVRNASSPCEDMGIAVEVFLALGLISLLENILVIGAIVRNRNLHIPMYFFVGSLAVADMLVSLSNFWETITIYLLTNDASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCRLYQRIMTGRRSGAIIAGIWAFCTSCGTVFIVYYY----------------------EESTYVVVCLIAMFLTMLLLMASLYTHMFLLARTH-RIPGHSSVRQRTGVKGAITLAMLLGVFIICWAPFFLHLILMISCPQNSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQGFRTPCRFPSTY------------ >V2R_RAT MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDSG--VFDCWAR---FAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASGRRPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEA-LERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDSSLMKDTPS--- >EDG2_MOUSE QPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIDHCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSNHTILAGVHSND >EDG1_RAT VKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI-S--SLSSCSTV------LPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRLTFISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKEFSRSKSDNSSH >CKR8_HUMAN DYTLDLSVTTVTDYYYPDIFSSPC---DAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQ--WVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVAS-ED-VLQCYSF-YNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQL---------KRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKS-CSQIFNYLGRQKS------SSCQ >B1AR_MACMU LPDGVATAARLLVPASPPASLLPPASEGPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRNAFQRLLCCARRAARRRHAAHGCLARPGPPPSPG >DBDR_.ENLA FQHLDSDQVASWQSPEMLMNKSVSRESQRRKELVAGQIVTGSLLLLLIFWTLFGNILVCTAVMRFRHRSRVTNIFIVSLAVSDLLVALLVMPWKAVAEVAGHWPFG-AFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTQRVALLMISTAWALSVLISFIPVQLSWHKSDH-STGNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQSCSQTSLRTSIKKETKVLKTLSIIMGVFVCCWLPFFILNCMVPFCDRSCVSETTFDIFVWFGWANSSLNPIIYAFNA-DFRKVFSSLLGCGHWCSTTPVETVNYNQDTLFHK--- >O00155 PTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAARRP-WPFGDGLCKLSTFALAGTRSAGALLLAGMSVDRYLAVVKLLARPLRTPRCAVASCCGVWAVALLAGLPSLVYRGLQPLPG-DSQCGE-----EPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRL-------RRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSVFRCRAQAANT >NY4R_HUMAN HLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPT-GWKPSISQAYLGIVLIWVIACVLSLPFLANSILENAD--KVVCTES---WPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEACHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEES---TVHTEVSKGSLR >SSR2_MOUSE QLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTEDGERSDLNETTETQRTLL >EDG2_SHEEP QPQFTAMNEPQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTTVTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIENCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENTSGPTEGSNHTILAGVHSND >5H6_MOUSE -----------MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLYKLRMTAPRALALILGAWSLAALASFLPLLLGWH---E-APGQCRLL--------ASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQMESRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASSGARPGLSLQQV >ACTR_CAVPO -------------MKHIIHASGNVNGTARNNSDCPHVALPEEIFFIISITGVLENLIIILAVIKNKNLQFPMYFFICSLAISDMLGSLYKILESILIMFRNMGSFETTTDDIIDTMFILSLLGSIFSLLAIAVDRYITIFHALYHSIVTMHRTIAVLSIIWTFCIGSGITMVLFFS----------------------HHHVPTVLTFTSLFPLMLVFILCLYVHMFLMARSH---ARNISTLPRGNMRGAITLTILLGVFIFCWAPFILHILLVTFCPNNTCYISLFHVNGMLIMCNAVIDPFIYAFRSPELRSAFRRMISYSKCL--------------------- >OPSD_ALLMI MNGTEGPDFYIPFSNKTGVVRSPFEYPQYYLAEPWKYSALAAYMFMLIILGFPINFLTLYVTVQHKKLRSPLNYILLNLAVADLFMVLGGFTTTLYTSMNGYFVFGVTGCYFEGFFATLGGEVALWCLVVLAIERYIVVCKPMSNFRFGENHAIMGVVFTWIMALTCAAPPLVGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFAIPLAVIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVSFLICWVPYASVAFYIFSNQGSDFGPVFMTIPAFFAKSSAIYNPVIYIVMNKQFRNCMITTLCCGKNPLGDDETATGTSSVSTSQVSPA >OPSD_RANTE MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWKYSILAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTITLYTSLHGYFVFGQSGCYFEGFFATLGGEIALWSLVALAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIITFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWVPYAYVAFYIFCNQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDDDASSAATSVSTSQVSPA >A2AC_CAVPO GPNASGAGEG----GGGVNASGAVWGPPPSQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAIISFPPLVSFYR-------PRCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQLPTPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKHILFRRRRRGFRQ----------------- >PE23_RAT ---------MAGVWAPEHSVEAHSNQS---SAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHYASHMKTRAT-PVLLGVWLSVLAFALLPVLGVG----RYSGTWCFISNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTN-YASSSTSLPCWSDQLER----- >OPSF_ANGAN MNGTEGPNFYVPMSNVTGVVRSPFEYPQYYLAEPWAYSALAAYMFFLIIAGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNIEGFFATLGGEIALWCLVVLAVERWMVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLFGWSRYIPEGMQCSCGMDHYAPNPETYNESFVIYMFICHFTIPLTVISFCYGRLVCTVKEATAQQQESETTQRAEREVTRMVIIMVISFLVCWVPYASVAWYIFTHQGSSFGPIFMTIPAFFAKSSSLYNPLIYICMNKQSRNCMITTLCCGKNPFEEEEGASTASSVSS--VSPA >OPSR_ORYLA NE--DTTRGSAFTYTNSNHTRDPFEGPNYHIAPRWVYNLATLWMFFVVVLSVFTNGLVLVATAKFKKLRHPLNWILSNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSTCGIAALWSLTIISWERWVVVCKPFGNVKFDAKWAIGGIVFSWVWSAVWCAPPVFGWSRYWPHGLKTSCGPDVFSGSDDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRAVAMQQKESESTQKAEREVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQFRTCIMQLFGKQVDDG-----SEVSS------VAPA >CKR5_CERAE ----MDYQVSSPTYDIDNYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPRIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >D2DR_CERAE ---MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC------------------------- >AA3R_SHEEP -------------------------MPVNSTAVSWTSVTYITVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLG--VTIHFYSCLFMTCLMLIFTHASIMSLLAIAVDRYLRVKLTVYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWN-MKA-D-FLPCRFR-----SVMRMDYMVYFSFFLWILVPLVVMCAIYFDIFYIIRNR--SSRETGAFYGREFKTAKSLLLVLFLFALCWLPLSIINCILYFDGQ--VPQTVLYLGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVMCQPSKSMDPS------------ >IL8B_RAT SGDIDSYN-YSSDPPFTLSDAAPC----PSANLDINRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNG--WIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIFILRTTVK-PS-TVVCYEN-IGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEG------------ >NY5R_MOUSE ASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPFPVFHSLVESS--KYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGAQEKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS--------------------- >OPS3_DROPS ARLSAESRLLGWNVPPDELRHIPEHWLIYPEPPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDFMMMIKTPIFIYNSFHQG-YALGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVITRPM-EGKMTHGKAIAMIIFIYLYATPWVVACYTESWGRFPEGYLTSCTFD--YLTDNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHNVDSNVDKSKEAAEIRIAKAAITICFLFFASWTPYGVMSLIGAFGDKTLLTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQKRCPWLAISEKAPESRAAEQQQTTAA---- >B1AR_MOUSE LPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLVALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACRRRAAHGCLARAGPPPSPG >O6A1_HUMAN ------------MEWRNHSGRVSEFVLLGFPAPVPIQVILFALLLLAYVLVLTENTLIIMAIRNHSTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFVGSKQLISFEGCMTQLYFFLGLGCTECVLLAVMANDRYMAICYLLNPVIVSGRLCVQMAAGSWAGGFGISMVKVFLISGL---SNHFFCDVSNLSCTDMSTAELTDFILAIFILLGPLSVTGASYVAITGAV--------MHIPSAAGRYKAFSTCASHFNVVIIFYAASIFIYARPKALS---AFDTNKLVSVLYAVIVPLLNPIIYCLRNQEVKRALCCILHLYQHQDPDPKKGSR------------ >GPR8_HUMAN PLDSRGSFSLPTMGANVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLAVADGLFTLVLPVNIAEHLLQY-WPFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLATVHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVYS-LQ-VPSCGLS-FPWPERVWFKASRVYTLVLGFVLPVCTICVLYTDLLRRLRAVR--RSGAKALGKARRKVTVLVLVVLAVCLLCWTPFHLASVVALTTDLPPLVISMSYVITSLTYANSCLNPFLYAFLDDNFRKNFRSILRC------------------------- >CCKR_.ENLA SSTNGTHNLTTANWPPWNLNCTPILDRKKPSPSDLNLWVRIVMYSVIFLLSVFGNTLIIIVLVMNKRLRTITNSFLLSLALSDLMVAVLCMPFTLIPNLMENFIFGEVICRAAAYFMGLSVSVSTFNLVAISIERYSAICNPLSRVWQTRSHAYRVIAATWVLSSIIMIPYLVYK----DRRVGHQCRLV---WPSKQVQQAWYVLLLTILFFIPGVVMIVAYGLISRELYRGKMDINNSEAKLMAKKRVIRMLIVIVAMFFICWMPIFVANTWKAFDELSTLTGAPISFIHLLSYTSACVNPLIYCFMNKRFRKAFLGTFSSCIKP----CRNFRATGASLSKFSYT >ETBR_RAT SSAPAEVTKGGRVAGVPPRS-FPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITRV--LRVCMLNQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFE-EKQSLEFKANDHGYDNFR >EDG2_HUMAN QPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIENCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTESSNHTILAGVHSND >5H1D_RAT SLPNQSLEGLPQEASNRSLNAT---GAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAAAMIAAVWAISICISIPPLFWR----H-E--SDCLVN-------TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRKLALERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS--------------------- >ET1R_BOVIN ELSFVVTTHQPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPRT--HRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPWKNHEQNNHNTE >GRE2_BALAM ----MSGGEASITGRTAPELN-ASAAPLDDERELGETVAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPIYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW-T-E--TPCTLT--------QR-LFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRSVHEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCPPSQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAFSRLLRCDRRMSA------------------- >LSHR_MOUSE ENELSGWDYDYDFCSPKTLQCTPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCSAAGFFTVFASELSVYTLTVITLERWHTITYAVLDQKLRLRHAIPIMLGGWIFSTLMATLPLVGVSSY----KVSICLPM-----VESTLSQVYILSILLLNAVAFVVICACYVRIYFAVQNP------ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPVNSCANPFLYAVFTKAFQRDFFLLLSRFGCCKHRAELYRRFNSKNGFPRSSK >MSHR_MOUSE STQEPQKSLLGSLNSN--ATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEVVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYY----------------------KKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHIAQKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW----------------------- >5H5A_RAT LPINLTSFSLSTPSTLEPNRSDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGE-S-E-SEECQVS--------REPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRATVTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW-DIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ----------------------- >BRS3_HUMAN QTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTMT--FESCTSY---VSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSIPTQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTMGTVPGTGSIQM >OPSD_CATBO GGGF-GNQTVVDKVPPEMLHLVDAHWYQFPPMNPLWHAILGFVIGILGMISVIGNGMVIYIFTTTKSLRTPSNLLVINLAISDFLMMLSMSPAMVINCYYETWVLGPLVCELYGLTGSLFGCGSIWTMTMIAFDRYNVIVKGLSAKPMTINGALLRILGIWFFSLGWTIAPMFGWNRYVPEGNMTACGTD--YLTKDLLSRSYILVYSFFCYFLPLFLIIYSYFFIIQAVAAHMNVRSAENQSTSAECKLAKVALMTISLWFMAWTPYLVINYAGIFETVK-INPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFQRFPSLACSSGPAG-ADTTEGTEKPAA--- >GASR_PRANA GSSLCHPGVSLLNSSSAGNLSCEPPRIRGTGTRELELAIRITLYAVIFLMSIGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLVAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQP---V-LQCMHR---WPSARVRQTWSVLLLMLLFFIPGVVMAVAYGLISRELYLGTPGASANQAKLLAKKRVVRMLLVIVLLFFLCWLPIYSANTWCAFDGPGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPSIASLSRLSYT >P2Y3_CHICK ----------------MSMANFTGGRNSCTFHEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLAMADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTG-----RTVCYDL-SPPDRSTSYFPYGITLTITGFLLPFAAILACYCSMARILCQK---ELIGLAVHKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRQDHCISY------------ >AG2R_.ENLA -----MSNASTVETSDVERIAVNC---SKSGMHNYIFIAIPIIYSTIFVVGVFGNSMVVIVIYSYMKMKTVASIFLMNLALSDLCFVITLPLWAAYTAMHYHWPFGNFLCKVASTAITLNLYTTVFLLTCLSIDRYSAIVHPMSRIWRTAMVARLTCVGIWLVAFLASMPSIIYRQIYL-TN--TVCAIV-YDSGHIYFMVGMSLAKNIVGFLIPFLIILTSYTLIGKTLKEV------YRAQRARNDDIFKMIVAVVLLFFFCWIPYQVFTFLDVLIQMDDIVDTGMPITICIAYFNSCLNPFLYGFFGKNFRKHFLQLIKYIPPKMRTHASVNTSLSD-------T >FSHR_PIG FDTMYSEFDYDLCNEVVDVICSPEPDTFNPCEDIMGHDILRVLIWFISILAITGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKTWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLQCKVQLRHAASIMLVGWIFAFTVALFPIFGISSY----KVSICLPM-----IDSPLSQLYVVSLLVLNVLAFVVICGCYTHIYLTVRNP------NIMSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDVFILLSKFGCYEMQAQTYRTNIHPRNGHCPPA >MSHR_DAMDA PVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >ETBR_HORSE LSAPPQMPKAGRTAGAQRRTLPPPPCERTIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDMITRI--LRICLLHQKTAFMQFYKNAKDWWLFSFYFCLPLAITAFFYTLETCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKHTLYDQSFLLVLEYIGINMASLNSCINPIALYLVSKRFKNCFKWCLCCWCQSFE-EKQSLEFKANDHGYDNFR >MSHR_CAPHI PALGSPRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSVLSITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >AG2S_RAT ------MTLNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKA----YKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTRPSD-------N >D5DR_FUGRU NFYNETEPTEPRGGVDPLRVVTAAEDVPAPVGGVSVRALTGCVLCALIVSTLLGNTLVCAAVIKFRHRSKVTNAFVVSLAVSDLFVAVLVMPWRAVSEVAGVWLFG-RFCDTWVAFDIMCSTASILNLCVISMDRYWAISNPFYERRMTRRFAFLMIAVAWTLSVLISFIPVQLNWHRASS-EQGDCNAS--------LNRTYAISSSLISFYIPVLIMVGTYTRIFRIAQTQRASESALKTSFKRETKVLKTLSVIMGVFVFCWLPFFVLNCVVPFCDVDCVSDTTFNIFVWFGWANSSLNPVIYAFNA-DFRKAFTTILGCSKFCSSSAVQAVDYHHDTTLQK--- >PI2R_BOVIN ------------------------MADSCRNLTYVRDSVGPATSTLMFVAGVVGNGLALGILGARRHRPSAFAVLVTGLGVTDLLGTCFLSPAVFAAYARNSARGRPALCDAFAFAMTFFGLASTLILFAMAVERCLALSHPYYAQLDGPRRARLALPAIYAFCTIFCSLPFLGLGQHQQYCPGSWCFIR---MRSAEPGGCAFLLAYASLVALLVAAIVLCNGSVTLSLCRMQRRRCPRPRAGEDEVDHLILLALMTGIMAVCSLPLTPQIRGFTQAIAPDSSEMGDLLAFRFNAFNPILDPWVFILFRKSVFQRLKLWFCCLYSRPAQGDSRTSRKDSSAPPALEG >A1AA_RABIT ----------MVFLSGNASDSSNCT-HPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKREAKNFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALSQ---------- >OPS4_DROPS SSGSDELQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLKAPIFIYNSFHRG-FALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPM-NRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFPEGYLTSCSFD--YLSDNFDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHNVESNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQKRCPWLGVNEKSGEASSAQTQQTSAA---- >5H1F_RAT -------------MDFLNSSD-QNLTSEELLNRMPSKILVSLTLSGLALMTTTINCLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQGLCDLWLSVDIICCTCSILHLSAIALDRYRAITDAVYARKRTPRHAGITITTVWVISVFISVPPLFWR----S-R--DQCIIK-------HDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLLKHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRN----------------------- >NK2R_CAVPO ----MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPF-QPRLSAPSTKAVIGGIWLVALALAFPQCFYST---GA---TKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRRHQHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEE----HTPSFSLRVNRC >5H1A_RAT -MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRT---DP--DACTIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRKNEEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR-------------------- >ACM2_PIG --------------MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VE-DGECYIQ------FFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >GPRV_HUMAN -----------------------MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALRFLLDLSRSVGMAFLAAVALDRYLRVVHPRKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQ--S--TRCHSF-YSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKR----LREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLCAVAHTSDVTGSLTYLHSVVNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDF------------ >YT66_CAEEL ----------------------------------------MGVTFHPGIVGNITNLMVLASRR-------LRAMYLRALAVADLLCMLFVLVFVSTEYLAKNKLYQIYQCHLMLTLINWALGAGVYVVVALSLERYISIVFPMFRTWNSPQRATRAIVIAFLIPAIFYVPYAITRYKGK---VTIYSMDD---IYTTFYWQIYKWTREAILRFLPIIILTVLNIQIMIAFRKRMFQNKRKEQGTQKDDTLMYMLGGTVLMSLVCNIPAAINLLLIDETLKKLDYQIFRAVANILEITNHASQFYVFCACSTDYRTTFLQKFPCFKTDYANRDRLRSVIQKQGSVEHTT >RGR_MOUSE ---------------------MAATRALPAGLGELEVLAVGTVLLMEALSGISLNGLTIFSFCKTPDLRTPSNLLVLSLALADTGISLNALVAAVSSLLRR-WPHGSEGCQVHGFQGFATALASICGSAAVAWGRYHHYCTRR---QLAWDTAIPLVLFVWMSSAFWASLPLMGWGHYDYEPVGTCCTLD--YSRGDRNFISFLFTMAFFNFLVPLFITHTSYRFME--------------QKFSRSGHLPVNTTLPGRMLLLGWGPYALLYLYAAIADVSFISPKLQMVPALIAKTMPTINAINYALHREMVCRGTWQCLSPQKSKKDRTQA--------------- >A2AA_PIG ----MGSLQPEAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKAQ-P--PRCEIN--------DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRRGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >PI2R_HUMAN ------------------------MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPRPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLR---MRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMKRHLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDS-SSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPRRDPRAPSAPVG >AA3R_CANFA -------------------------MAVNGTALLLANVTYITVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLG--ITIQFYNCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWN-MKE-H-FLSCQFS-----SVMRMDYMVYFSFFTWILIPLVVMCAIYLDIFYVIRNK--NSKETGAFYGREFKTAKSLFLVLFLFAFSWLPLSIINCITYFHGE--VPQIILYLGILLSHANSMMNPIVYAYKIKKFKETYLLIFKTYMICQSSDSLDSS------------ >CB1R_MOUSE EFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCK-K--LQSVCSDI------FPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGHANNTASMHRAA >OPSD_CANFA MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFAIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSDFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMITTLCCGKNPLGDDEASASASKTETSQVAPA >BRS3_CAVPO QTLISITNDTESSSSVVSNDTTNKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLALGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPSNAILKTCAKAGCIWIMSMIFALPEAIFSNVHTMT--SEWCAFY---VSEKLLQEIHALLSFLVFYIIPLSIISVYYSLIARTLYKSIPTQSHARKQVESRKRIAKTVLVLVALFALCWLPNHLLNLYHSFTHKAAIHFIVTIFSRVLAFSNSCVNPFALYWLSKTFQKQFKAQLFCCKGELPEPPLAATMGRVSGTENTHI >OPSD_DIPAN MNGTEGPFFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWTMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFTIPLTVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVIMMVIAFLVCWLPYASVAWYIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >AG2R_MOUSE ------MALNSSTEDGIKRIQDDC---PRAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYF-TN--TVCAFH-YESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------N >YMJC_CAEEL NLRLNESPYKYVMSNNTTIPSCLTDRQMSLSVSSTEGVLIGTIIPILVLFGISGNILNLTVLLAPNL-RTRSNQLLACLAVADIVSLVVILPHSMAHYETFERKFYGKYKFQIIAMTNWSIATATWLVFVICLERLIIIKYPLPRNVVTIIVVTTFILTSYNHVSHACAEKLFCNGTQY--S-RWFRNEPPNSEFMKSVVRVAPQVNAIFVVLIPVVLVIIFNVMLILTLRQRKTISQFTQLQSKTEHKVTITVTAIVTCFTITQSPSAFVTFLSSYVH--RDWVTLSAICTILVVLGKALNFVLFCLSSASFRQRLLMQTKQGILRKSTRYTSVA------------ >OPSG_ASTFA NE--ETTRESAFVYTNANNTRDPFEGPNYHIAPRWVYNLASLWMIIVVIASIFTNSLVIVATAKFKKLRHPLNWILVNLAIADLGETVLASTISVFNQVFGYFVLGHPMCIFEGWTVSVCGITALWSLTIISWERWVVVCKPFGNVKFDGKWAAGGIIFAWTWAIIWCTPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVASYMVTLLLTCCILPLSVIIICYIFVWNAIHQVAQQQKDSESTQKAEKEVSRMVVVMILAFILCWGPYASFATFSALNPGYAWHPLAAALPAYFAKSATIYNPIIYVFMNRQFRSCIMQLFGKKVEDA-----SEVSTAS-------- >DUFF_HUMAN FEDVWNSSYGVNDSFPDGDYDANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGST--RSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQ--------VPGLTLGLTVGIWGVAALLTLPVTLASG------SGGLCTLI-YSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKA-------------------LGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGS------------ >OPR._RAT GSHFQGNLSLLN---ETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEE---IECLVE-IPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVGLGCKTSETVPR >TRFR_SHEEP ------------MENETGSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLSLNSNRYFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPVEKPANYSVKESDHFSTELDD >ACTR_MESAU -------------MKHIITPYEHTNDTARNNSDCPDVVLPEEIFFTISIIGVLENLIVLLAVVKNKNLQCPMYFFICSLAISDMLGSLYKILENILIMFRNRGNFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALYHSIVTMRRTIITLTVIWIFCTGSGIAMVIFFS----------------------HHHVPTVLTFTSLFPLMLVFILCLYIHMFLLARSH---ARKISTLPRANMKGAITLTILLGVFIFCWAPFILHVLLMTFCPNNVCYMSLFQINGMLIMCNAVIDPFIYAFRSPELRDAFKKMFSCHRYQ--------------------- >CKR7_HUMAN QDEVTDDYIGDNTTVDYTLFESLC---SKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKS--WVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQR-SE-AMRCSLI---TEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTL---------LQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWS--------HIRR >O.YR_SHEEP GAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLSLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLAVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFKQMWSVWDADA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFQDLVQRFLCCSFRRLKGSQLGEHSYTFVLSRHSS >GPR7_HUMAN MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATARVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD--QG-RRQCVLV-FPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMR--DSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPPLVIAISYFITSLTYANSCLNPFLYAFLDASFRRNLRQLITCRAAA--------------------- >GPRJ_HUMAN TETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPL-SFKVSREKAKKMIAASWIFDAGFVTPVLFFYG---SNW-HCNYFLP-----SSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIDGR-RTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTIKKNYVGISEIPS >OAJ1_HUMAN --MLLCFRFGNQSMKRENFTLITDFVFQGFSSFHEQQITLFGVFLALYILTLAGNIIIVTIIRIDLHLHTPMYFFLSMLSTSETVYTLVILPRMLSSLVGMSQPMSLAGCATQMFFFVTFGITNCFLLTAMGYDRYVAICNPLYMVIMNKRLRIQLVLGACSIGLIVAITQVTSVFRL---PPHFFCDIRKLSCIDTTVNEILTLIISVLVLVVPMGLVFISYVLIISTI--------LKIASVEGRKKAFATCASHLTVVIVHYSCASIAYLKPKSEN---TREHDQLISVTYTVITPLLNPVVYTLRNKEVKDALCRAVGGKFS---------------------- >RDC1_CANFA YAEPGNFSDISWPCNSSDCIVVDTVLCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVVTIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLTCMSVDRYLSITYFATSSRRKKVVRRAVCVLVWLLAFCVSLPDTYYLKTVTNNE--TYCRSFYPEHSVKEWLISMELVSVVLGFAIPFCVIAVFYCLLARAI---------SASSDQEKQSSRKIIFSYVVVFLVCWLPYHVVVLLDIFSILHNFLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNAK-- >CML1_RAT EYEGYNDSSIYGEEYSDGSDYIVDLEEAGPLEAKVAEVFLVVIYSLVCFLGILGNGLVIVIATFKMK-KTVNTVWFVNLAVADFLFNIFLPIHITYAAMDYHWVFGKAMCKISSFLLSHNMYTSVFLLTVISFDRCISVLLPVSQNHRSVRLAYMTCVVVWVWLSSESPPSLVFGHVST-SF--HSTHPR-TDPVGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKL---------QRNRQAKTKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVSVFSLGLPLATAVAIANSCMNPILYVFMGHDFKK-FKVALFSRLVNALSEDTGPSFTKMSSLIEKAS >FSHR_EQUAS --MMYSEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYDILRVLIWFISILAITGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFGSELSVYTLTAITLERWHTITHAMLECKVQLRHAASVMLVGWIFGFGVGLLPIFGISTY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NIVSSSSDTKIAKRMGILIFTDFLCMAPISFFGISASLKVALITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQTYRTISHPKNGPCPPT >OPSD_MULSU MNGTEGPYFYIPMVNTTGIVRSPYDYPQYYLVNPAAYAALGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAVERWMVVCKPISNFRFGENHAIMGLAMTWLMASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFCCHFMIPLIIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLVCWLPYASVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICMNKQFRNCMITTLCCGKNPFEEEEGASSSSVSSSSVSPAA >NK3R_HUMAN GNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATKIVIGSIWILAFLLAFPQCLYSK---GR---TLCFVQ--WPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGG--PCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSY----TTRFHPNRQSSM >CKR5_CERTO ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSPHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >PI2R_MOUSE DGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIR---MRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMRRHFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDS--REMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPRRDPPAPTSLQA >FSHR_CHICK FGPVENEFDYGLCNEVVDFVCSPKPDAFNPCEDIMGYNVLRVLIWFINILAITGNTTVLIILISSQYKLTVPRFLMCNLAFADLCIGIYLLFIASVDIQTKSWQTG-AGCNAAGFFTVFASELSVYTLTVITLERWHTITYAMLNRKVRLRHAVIIMVFGWMFAFTVALLPIFGISSY----KVSICLPM-----IETPFSQAYVIFLLVLNVLAFVIICICYICIYFTVRNP------NVISSNSDTKIAKRMAILIFTDFLCMAPISFFAISASLRVPLITVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDFFILLSKFGCCEMQAQIYRTNFHTRNGHYPTA >OPRM_BOVIN FSHLEGNLSDPCGPNRTELGGSDRLCPSAGSPSMITAIIIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDLRTPRNAKIINICNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPILIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRIPSTANTVDRTNH >P2Y5_HUMAN --------------------MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLVSNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRN-WPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHS---ASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKP----VTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGNLQTLKSKIFDN >HM74_HUMAN ----------MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWNFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQ-PA--NVCISF-----SICHTFRWHEAMFLLEFLLPLGIILFCSARIIWSLRQR------QMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNTGDPNKTRGAPE >OPSD_DICLA MNGTEGPFFYVPMVNTTGIVRSPYDYPQYYLVSPAAYAALGAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNMEGFFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFGENHAIMGLAFTWVMACSCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFACHFIIPMCVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVVIMGIAFLICWCPYASVAWYIFTHQGSEFGPVFMTLPAFFAKTSSVYNPLIYILMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >GPRW_HUMAN GTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMA-RTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQ-WLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTR-FNSNETAQIWI-----VVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKL---------LREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRV-PRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSPRE--------- >UL33_HSV6U --------------------MDTVIELSKLQFKGNASCTSTPTLKTARIMESAVTGITLTTSIPMIIKHNATSFYVITLFASDFVLMWCVFFMTVNRKQL--FSFNRFFCQLVYFIYHAVCSYSISMLAIIATIRYK-TLHRRKKTESKTSSTGRNIGILLLASSMCAIPTALFVKTNGM-KKTGKCVVYSSKKAY-ELFLAVKIVFSFIWGVLPTMVFSFFYVIFCKAL---------HDVTEKKYKKTLFFIRILLLSFLLIQIPYIAILICEIAFLYMARVEILQLIIRLMPQVHCFSNPLVYAFTGGELRNRFTACFQSFFPKTLCSTQKRKDQNSKSKASVEK >A1AB_HUMAN HNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRRRRRRRRRTYRPWTRGGSLE >OPSD_SPHSP GG-Y-GNQTVVDKVLPEMLHLIDPHWYQFPPMNPLWHGLLGFVIGCLGFVSVVGNGMVIYIFSTTKGLRTPSNLLVVNLAFSDFLMMLSMSPPMVINCYYETWVLGPFMCELYALLGSLFGCGSIWTMVMIALDRYNVIVKGLAAKPMTNKTAMLRILGIWAMSIAWTVFPLFGWNRYVPEGNMTACGTD--YLNKEWVSRSYILVYSVFVYFLPLATIIYSYWFIVQAVSAHMNVRSAENANTSAECKLAKVALMTISLWFFAWTPYLVTDFSGIFEWGK-ISPLATIWCSLFAKANAVYNPIVYGISHPKYRAALNKKFPSLACASEPDDTASQSDEKSASA---- >ET1R_RAT EFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPRT--HRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPWKNQEQN-HNTE >B1AR_PIG LPDGAATAARLLVPASPPASLLTPASEGSVQLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRAAR-ALVCTVWAISALVSFLPILMHWWRDR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRVARGSCAAAGCLAVARPPPSPG >OLF3_RAT -------------MDSSNRTRVSEFLLLGFVENKDLQPLIYGLFLSMYLVTVIGNISIIVAIISDPCLHTPMYFFLSNLSFVDICFISTTVPKMLVNIQTQNNVITYAGCITQIYFFLLFVELDNFLLTIMAYDRYVAICHPMYTVIMNYKLCGFLVLVSWIVSVLHALFQSLMMLAL---PPHYFCEPNQLTCSDAFLNDLVIYFTLVLLATVPLAGIFYSYFKIVSSI--------CAISSVHGKYKAFSTCASHLSVVSLFYCTGLGVYLSSAANN---SSQASATASVMYTVVTPMVNPFIYSLRNKDVKSVLKKTLCEEVIRSPPSLLHFFCFIFCY------ >5H5A_HUMAN LPVNLTSFSLSTPSPLETNHSGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGE-S-E-SEECQVS--------REPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRATVPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSC-DIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH----------------------- >OPRD_RAT FSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPGA---VVCTLQ-FPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL-SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRVTACTPSDGPG >CKRV_MOUSE EIPAVTEPSYNTVAKNDFMSGFLC---FSINVRAFGITVPTPLYSLVFIIGVIGHVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLSTLPFWVDYIMKGD-WIFGNAMCKFVSGFYYLGLYSDMFFITLLTIDRYLAVVHVVALRARTVTFGIISSIITWVLAALVSIPCLYVFKSQM-EF-YHTCRAILPRKSLIRFLRFQALTMNILGLILPLLAMIICYTRIINVL---------HRRPNKKKAKVMRLIFVITLLFFLLLAPYYLAAFVSAFEDVLQQVDLSLMITEALAYTHCCVNPVIYVFVGKRFRKYLWQLFRRHTAITLPQWLPFLA-------SARL >THRR_RAT PLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAACYCNMYASIMLMTVISIDRFLAVVYPISLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQ--N--TTCHDVLNETLLHGFYSYYFSAFSAIFFLVPLIISTVCYTSIIRCL------SSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDETAYFAYLLCVCVTSVASCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGDTCS-------- >DADR_PIG --------------MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-TTHNCDSS--------LSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQAECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGCIDSITFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPTSTNAIETAVVFSSH----- >GRHR_BOVIN --MANSDSPEQNENHCSAINSSIPLTPGSLPTLTLSGKIRVTVTFFLFLLSTIFNTSFLLKLQNWTQKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITKPL-AVKSNSKLGQFMIGLAWLLSSIFAGPQLYIFGMIHEG--FSQCVTH--SFPQWWHQAFYNFFTFSCLFIIPLLIMVICNAKIIFTLTRVPHKNQSKNNIPRARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPDMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >OLF3_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIRLISVDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERKTISYVGCILQYFSFVLLTTSECLLLAVMAYDRYVAICKPLYPAIMTKAVCWRLVESLYFLAFLNSLVHTCGLLKL---SNHFFCDISQISSSSIAISELLVIISGSLFVMSSIIIILISYVFIILTV--------VMIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRLTATTFGFIDSKAVQ-------------- >ML1A_PHOSU -------MKGNGSTLLNASQQAPGVGEGGGPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAIADLVVAIYPYPLVLTSIFNNGWNLGYLHCQISAFLMGLSVIGSIFNITGIAINRYCYICHSLYDRLYSNKNSLCYVFLIWVLTLVAIMPNLQTGT-LQYDP-IYSCTFT------QSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWILVLQVRR-PDSKPRLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLIVASDPATRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRQEYKRILVSLFTAKMCFVDSSNCKPAPLIANNNL >NY2R_HUMAN EEMKVEQYGP-QTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKRISFLIIGLAWGISALLASPLAIFREYSLFE--IVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHSPG-AANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKNLEVRKNSG >FMLR_HUMAN -----------METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMT-HTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFLFTIVDINLFGSVFLIALIALDRCVCVLHPVTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPSPWPKERINVA------VAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKI---------HKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIREKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTTL---------- >NK1R_CAVPO -----MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVICVIWVLALLLAFPQGYYST---GR---VVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLE---IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADY----STRYFQTQGSVY >ML1B_HUMAN NGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS-LEYDP-IYSCTFI------QTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARK-PESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKQSPAPPIIGVQH >C3AR_RAT --------------MESFTADTNSTDLHSRPLFKPQDIASMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPICQNHRSVRTAFAVCGCVWVVTFVMCIPVFVYRDLLV-ED-DYFDQLM-YGNHAWTPQVAITISRLVVGFLVPFFIMITCYSLIVFRM--------RKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQEEVVLPWDHMSIALASANSCFNPFLYALLGKDFRKKARQSVKGILEAAFSEELTHSAPS--------- >OPSB_GECGE MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLADPWKFKVLSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIGGQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWSRFIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVREAAAQQQESATTQKAEKEVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQFRNCMVTTICCGKNPFGDEDVSSSVSSVSSSQVAPA >SSR5_RAT LSLASTPSWNAS---AASSGNHNWSLVGSASPMGARAVLVPVLYLLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLSARWRRPRVAKMASAAVWVFSLLMSLPLLVFADVQE-----GTCNLS-WPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAMR--VGSSRRRRSEPKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIERPQATLPTRSCE >B2AR_CANFA MGQPANRSVFLLAPNGSHAPDQ----GDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQGRSHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWVGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGYSDYAGEHSGCHLG >CKR6_MOUSE FGTDDYDN---TEYYSIPPDHGPC---SLEEVRNFTKVFVPIAYSLICVFGLLGNIMVVMTFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATNT-WVFSDALCKLMKGTYAVNFNCGMLLLACISMDRYIAIVQATRVRSRTLTHSKVICVAVWFISIIISSPTFIFNKKYE-LQ-RDVCEPRRSVSEPITWKLLGMGLELFFGFFTPLLFMVFCYLFIIKTL---------VQAQNSKRHRAIRVVIAVVLVFLACQIPHNMVLLVTAVNTGKKVLAYTRNVAEVLAFLHCCLNPVLYAFIGQKFRNYFMKIMKDVWCMRRKNKMPGFESY-----ISRQ >NYR_DROME TLSGLQFETYNITVMMNFSCDDYDLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCEPSSFISLFILNWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPL-KPRITKRYATFIIAGVWFIALATALPIPIVSGLDI---WHTKCEKYREMWPSRSQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKPGETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFADPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVSGTGPALPLNRM >HH2R_MOUSE -------------------MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWRFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWN--RN-TF-KCKVQ--------VNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQR--ISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDD-VNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRRSQSREGRW--- >TRFR_BOVIN -----------MENETGSELN-QTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNLNSNRYFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPVEKPANYSVKESDRFSTELDD >OPSP_ICTPU -------MASIILINFSETDTLHLGSVNDHIMPRIGYTILSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFFGIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWGSYQLEGVMTSCAPN--WYRRDPVNVSYILCYFMLCFALPFATIIFSYMHLLHTLWQVAKLVADSGSTAKVEVQVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQFRDYALPCLLCGKNPWAAKEGRDSTVSKNTSVSPL- >OPSR_.ENLA NDDDDTTRSSVFTYTNSNNTRGPFEGPNYHIAPRWVYNLTSIWMIFVVFASVFTNGLVIVATLKFKKLRHPLNWILVNMAIADLGETVIASTISVFNQIFGYFILGHPMCVLEGFTVSTCGITALWSLTVIAWERWFVVCKPFGNIKFDEKLAATGIIFSWVWSAGWCAPPMFGWSRFWPHGLKTSCGPDVFSGSSDPGVQSYMLVLMITCCIIPLAIIILCYLHVWWTIRQVAQQQKESESTQKAEREVSRMVVVMIVAYIFCWGPYTFFACFAAFSPGYSFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIYQMFGKKVDDG-----SEVVSSVSNSSVSPA >ML1._MOUSE ---------MGPTKAVPTPFGCIGCKLPKPDYPPALIIFMFCAMVITVVVDLIGNSMVILAVTKNKKLRNSGNIFVASLSVADMLVAIYPYPLMLYAMSVGGWDLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYICHSLYKRIFSLRNTCIYLVVTWVMTVLAVLPNMYIGT-IEYDP-TYTCIFN------YVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWIKVLAARD-AGQNPDNQFAEVRNFLTMFVIFLLFAVCWCPVNVLTVLVAVIPKEKIPNWLYLAAYCIAYFNSCLNAIIYGILNESFRREYWTIFHAMRHPILFISHLISTRALTRARVRAR >OPSG_CHICK MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWSRYMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVREAAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTICCGKNPFGDEDVSSTVSSVSSSQVSPA >GRHR_HUMAN --MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPL-ALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHKV--FSQCVTH--SFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVPHENQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >5HT2_APLCA ----------------MLCGRLRHTMNSTTCFFSHRTVLIGIVGSLIIAVSVVGNVLVCLAIFTEPISHSKSKFFIVSLAVADLLLALLVMTFALVNSLYGYWLFGETFCFIWMSADVMCETASIFSICVISYNRLKQVQKPLYEEFMTTTRALLIIASLWICSFVVSFVPFFLEWHELGD-PKPECLFD--------VHFIYSVIYSLFCFYIPCTLMLRNYLRLFLIAKKH-RIHRLHRNQGTQGSKAARTLTIITGTFLACWLPFFIINPIEAVDEHL-IPLECFMVTIWLGYFNSCVNPIIYGTSNSKFRAAFQRLLRCRSVKSTVSSISPVSWIRPSLLDGP- >OPSD_ASTFA MNGTEGPYFYVPMSNATGVVRSPYEYPQYYLAPPWAYACLAAYMFFLILVGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSLNGYFVFGRLGCNLEGFFATFGGINSLWCLVVLSIERWVVVCKPMSNFRFGENHAIMGVAFTWFMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVVHFLTPLFVITFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVILMFIAYLVCWLPYASVSWWIFTNQGSEFGPIFMTVPAFFAKSSSIYNPVIYICLNKQFRHCMITTLCCGKNPF--EEEEGATEASSVSSVSPA >5H2C_HUMAN GLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD-VF--NTTCVL---------NDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQKKKPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIALSGRELNVNIY >DBDR_RAT PGRNRTAQPARLGLQRQLAQVDAPAG--SATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-TFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDEG-RTENCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQRGADPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGCVSETTFDIFVWFGWANSSLNPIIYAFNA-DFRKVFAQLLGCSHFCFRTPVQTVNYNQDTVFHK--- >EDG1_MOUSE VKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPSMGWNCI-S--SLSSCSTV------LPLYHKHYILFCTTVFTLLLLSIAILYCRIYSLVRTRLTFISKGSRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKEFSRSKSDNSSH >B3AR_BOVIN MAPWPPGNSSLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRALAAVVLVWVVSAAVSFAPIMSKWWRIQ-R--RCCTFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPS-VSGPTFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCR---PEEHLAAAGAPTALTSPAGP >NY2R_CAVPO EEIKVEPYGPGHTTPRGELAPDPEPELIDSTKLTEVRVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTVTLTVIALDRHRCIVYHL-DSKISKQNSFLIIGLAWGISALLASPLAIFREYSLFE--IVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISVSYVRIWSKLKNHSPG-AANDHYHQRRQKTTKMLVFVVVVFAVSWLPLHAFQLAVDIDSQVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCQQRLDAIQSE---AKTNVEVEKNHG >PE22_RAT ---------------MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQLAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQ--------HGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMRGPRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSS---RKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGAS--QTDLCGQL-- >A2AB_MOUSE --------------------MSGPAMVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCELN--------QEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSGVAWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTGW------------------ >AG2S_HUMAN ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF-TN--TVCAFH-YESRNSTLPIGLGLTKNILGSCFPFLIILTSYTLIWKALKKA----YEIQKNNPRNDDIFRIIMAIVLFFFFSWIPHQIFTFLDVLIQQGDIVDTAMPITIWIAYFNNCLNPLFYGFLGKKFKKDILQLLKYIPPKAKSHSNLSTRPSD-------N >B2AR_BOVIN MGQPGNRSVFLLAPNASHAPDQ----NVTLERDEAWVVGMGILMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGACHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYLAITSPFYQCLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQPYAIASSIVSFYLPLVVMVFVYSRVFQVAKRQGRSQRRTSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIKDNL-IRKEIYILLNWLGYINSAFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGCSDYTGEQSGYHLG >IL8B_RABIT G--DFSNYSYSTDLPPTLLDSAPC----RSESLETNSYVVLITYILVFLLSLLGNSLVMLVILYSRSTCSVTDVYLLNLAIADLLFATTLPIWAASKVHG--WTFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTMIQKRHLVKFICLSMWGVSLILSLPILLFRNAIF-NS-SPVCYED-MGNSTAKWRMVLRILPQTFGFILPLLVMLFCYVFTLRTL---------FQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLTDTLMRTHNDIDRALDATEILGFLHSCLNPIIYAFIGQKFRYGLLKILAAHGLISKEFLAKES------------ >GASR_RAT GSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQP---V-LQCMHR---WPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGPGPPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPSIASLSRLSYT >A1AB_MOUSE HNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGCLG-AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTDLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRTYRPWTRGGSLE >OPSR_FELCA AGLEDSTRASIFTYTNSNATRGPFEGPNYHIAPRWVYHVTSAWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIAGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMITCCIIPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVMVMIFAYCVCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCIMQLFGKKVDDG-----SELASSV--SSVSPA >P2Y7_HUMAN -------------------MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPK--NMSLCFPR---YPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRL---------QARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTQTARSGPAALEP >GPRL_HUMAN ---------MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITKPLYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWG---K-P-VFQWCAE-----SWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHRFSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFLTTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDGPLNGCHI---- >CKR3_MOUSE TDEIKTVVESFETTPYEYEWAPPC---EKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNE-WGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVALRARTVTFATITSIITWGLAGLAALPEFIFHESQD-SF-EFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLVMVICYSGIIKTL---------LRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHRTFKHLDLAMQVTEVIAYTHCCVNPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLT-------SSVS >HH1R_MOUSE ----------MRLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLGVLYAVRSERKLHTVGNLYIVSLSVADLIVGAIVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASATILGAWFLSFLWVIPILGWHHFT--EL-EDKCETD------FYNVTWFKIMTAIINFYLPTLLMLWFYVKIYNGVRRHLRSQYVSGLHLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSC-CSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS----------------------- >SSR1_HUMAN GEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAADG--TVACNML-MPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQ--DDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLS-----WMDNAAETALKSRAYSVED >MC5R_MOUSE -MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNDTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALYHHIMTARRSGVIIACIWTFCISCGIVFIIYYY----------------------EESKYVIICLISMFFTMLFFMVSLYIHMFLLARNH-RIPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY------------ >OPSD_CHELA MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFSEDHAIMGLAFTWVMASACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLVCWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >OLF6_RAT ----------MAWSTGQNLSTPGPFILLGFPGPRSMRIGLFLLFLVMYLLTVVGNLAIISLVGAHRCLQTPMYFFLCNLSFLEIWFTTACVPKTLATFAPRGGVISLAGCATQMYFVFSLGCTEYFLLAVMAYDRYLAICLPLYGGIMTPGLAMRLALGSWLCGFSAITVPATLIARL---SNHFFCDISVLSCTDTQVVELVSFGIAFCVILGSCGITLVSYAYIITTI--------IKIPSARGRHRAFSTCSSHLTVVLIWYGSTIFLHVRTSVES---SLDLTKAITVLNTIVTPVLNPFIYTLRNKDVKEALRRTVKGK------------------------ >D4DR_HUMAN ---MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLN---G-R--AVCRL---------EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWPPPRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC----------------------- >NY2R_MOUSE VEVKVEPYGPGHTTPRGELPPDPEPELIDSTKLVEVQVILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKRISFLIIGLAWGISALLASPLAIFREYSLFE--IVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLRNHSPG-AASDHYHQRRHKMTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKNLEVKKNNG >ETBR_MOUSE SSAPAEVTKGGRGAGVPPRS-FPPPCQRNIEISKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDMITRV--LRVCMLNQKTAFMQFYKTAKDWWLFSFYFCLPLAITAVFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFE-EKQSLEFKANDHGYDNFR >NK2R_RAT ----MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAIIAGIWLVALALASPQCFYST---GA---TKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRPRHHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----HTPSLSRRVNRC >OPR._MOUSE GSHFQGNLSLLN---ETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEE---IECLVE-IPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVGLGCKTSETVPR >YLD1_CAEEL --------------------------MIIFYLYVATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVGTSWTYNLYYDWWYG-DLCTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNPLQKRPLSRKRSVIAILIIWVVSTVTALPFAIAASVNSVTSKAHVCSAP--------VNTFFEKVLFGIQYALPIIILGSTFTRIAVAFRATEATSSLKNNHTRAKSKAVKMLFLMVVAFVVCWLPYHIYHAFALEEFFDARGKYAYLLIYWIAMSSCAYNPIIYCFANERFRIGFRYVFRWIPVIDCKKEQYEYMRSMAISLQKGR >5HT_BOMMO LPLQNCSWNSTGWEPNWNVTVWQASAPFDTPAALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLVACLVMPLGAVYEVVQRWTLGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTNI-YIHASTAKRVGMMIACVWTVSFFVCIAQLLGWKDPDS-E--LRCVVS--------QDVGYQIFATASSFYVPVLIILILYWRIYQTARKRPSLKPKEAADSKRERKAAKTLAIITGAFVACWLPFFVLAILVPTCDC-EVSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLLCGRRVRRRRAPQ--------------- >OPSD_SALPV MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILLGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWIMACACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFTCHFCIPLTIIGFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVILMVVGFLVCWLPYASVAWYIFSNQGSQFGPLFMTIPAFFAKSSSVYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSSVSSSSVSPAA >OPSD_LITMO MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLMVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLICWCPYAGVAWWIFTHQGSDFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >P2UR_RAT ----MAAGLDSWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLSLSWGHARYARRVAAVVWVLVLACQAPVLYFVTTS-----RITCHDT-SARELFSHFVAYSSVMLGLLFAVPFSIILVCYVLMARRLLKP---AYGTTGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPATEPTPSPQARRKLTDTVRKDLSISS >OLF4_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIALISVDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERKTISYIGCILQYFSFVLLTVTESLLLAVMAYDRYVAICKPLYPSIMTKAVCWRLVKGLYSLAFLNSLVHTSGLLKL---SNHFFCDNSQISSSSTTLNELLVFIFGSLFAMSSIITILISYVFIILTV--------VRIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRVIATNVWIH-------------------- >LSHR_RAT ENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNY----KVSICLPM-----VESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNP------ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRSNCKNGFPGASK >MSHR_BOVIN PALGSQRRLLGSLNCTPPATLPFTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHKVILLCLVGLFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >PE24_RAT --------------------MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFID---WTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMAAAVASFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSRRTSSAMSGHSR >5H1B_FUGRU ----MEGTNNTTGWTHFDSTSNRTSKSFDEEVKLSYQVVTSFLLGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNRWTLGQIPCDIFISLDMLCCTSSILHLCVIALDRYWAITEPIYMKKRTPRRAAVLISVTWLVGFSISIPPMLIMRSQPA-N--KQCKIT--------QDPWYTIYSTFGAFYIPLTLMLVLYGRIFKAARFRRHEETKRKIALARERKTVKTLGIIMGTFILCWLPFFIVALVMPFCQESFMPHWLKDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHFCRA-------------------- >GP39_HUMAN -------MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYETSNMSICTNL-----SRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSRPPKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLTDSARFVQRPLL >BRB2_HUMAN FSADMLNVTLQGPTLNGTFAQSKC---PQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKE-HN--TACVIS---YPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNN---EMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGRIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQLRTS-------I >RDC1_HUMAN YAEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFSGIFFLTCMSVDRYLSITYFTTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTNNE--TYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI---------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNAK-- >OPSB_ASTFA QEFQEDFYIPIPLDTNNITALSPFLVPQDHLGGSGIFMIMTVFMLFLFIGGTSINVLTIVCTVQYKKLRSHLNYILVNLAISNLLVSTVGSFTAFVSFLNRYFIFGPTACKIEGFVATLGGMVSLWSLSVVAFERWLVICKPVGNFSFKGTHAIIGCALTWFFALLASTPPLFGWSRYIPEGLQCSCGPDWYTTENKYNNESYVMFLFCFCFGFPFTVILFCYGQLLFTLKSAAKAQADSASTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVFNRGQSFDLRLGTIPSCFSKASTVYNPVIYVFMNKQFRSCMMKLIFCGKSPFGDDEEASSSSVGPEK----- >CB1B_FUGRU TNASDFPLSNGSGEATQCGEDIVDNMECFMILTPAQQLVIVILAITLGTFTVLENFVVLCVILHSHTRSRPSYHFIGSLAVADLIGSIIFVYSFLDFHVLHR-KDSPSIFLFKLAGVIASFTASVGSLFLTAIDRYVSIHRPMYKRIITKTKAVIAFSVMWAISIEFSLLPLLGWNCK-R--LHSVCSDI------FPLIDEKYLMFWIGMTTVLLLFIIYAYMFILWKSHHHSEGQTVRPEQARMDLRLAKTLVLILVALIICWGPLLAIMVYDLFGRVNDFIKTVFAFCSMLCLLNSTINPVIYAMRSKDLRRAFVNICHMCRGTTQSLDSSAEVRSTGGRAGKDR >5H2B_HUMAN ILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIANQYNSRATAFIKITVVWLISIGIAIPVPIKGIET-NP---ITCVLT------KERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKRRTGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRNPMAENSKFFK >OAR2_LYMST RNFSVSADVWLCGANFSQEWQLMQPVCSTKYDSITIFITVAVVLTLITLWTILGNFFVLMALYRYGTLRTMSNCLIGNLAISDLLLAVTVLPISTVHDLLGYWVFGEFTCTLWLCMDVLYCTASIWGLCTVAFDRYLATVYPVYHDQRSVRKAVGCIVFVWIFSIVISFAPFIGWQHM-S-F--YQCILF--------TSSSYVLYSSMGSFVIPAILMAFMYVRIFVVLHNQRNKLSMKRRFELREQRATKRMLLIMACFCVCWMPFLFMYILRSVCDTCHMNQHFVAAIIWLGYVNSSLNPVLYTLFNDDFKVAFKRLIGARSPSAYRSPGPRR------------ >GRPR_HUMAN DCFLLNLEVDHFMHCN-ISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPQT--FISCAPY---HSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSLPVNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIR--SHSMTSLKSTNPSVA >DBDR_HUMAN PGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDED-NAENCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQSAADTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHCVSETTFDVFVWFGWANSSLNPVIYAFNA-DFQKVFAQLLGCSHFCSRTPVETVNYNQDIVFHK--- >B2AR_MESAU MGPPGNDSDFLLTTNGSHVPDH----DVTEERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYIAITSPFYQSLLTKNKARMVILMVWIVSGLTSFLPIQMHWYRAI-D--TCCDFF--------TNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQGRSLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWLGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSSKAYGNGYSDYMGEASGCQLG >5H1B_HUMAN PAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVYSAKRTPKRAAVMIALVWVFSISISLPPFFWR----E-E--SECVVN-------TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS--------------------- >GPRH_HUMAN ------MNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQVCL-QLYRE----------KASHHALVSLAVAFTFPFITTVTCYLLIIRSLR------QGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKAKSEL------- >ACM1_MOUSE ------------MNTSVPPAVSPNITVLAPGKGPWQVAFIGSTTGLLSLATVTGNLLVLISIKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTVNPMCYASCNKAFRDHFRLLLLCRWDKRRWRKIPKRPSRQC------- >B3AR_SHEEP MAPWPPGNSFLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--RCCTFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVDTRQGVPRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPS-VSGPTFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCPPEEHLAAASPPTVLTSPAGPRQP >A1AD_MOUSE TGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEP--VP--RFCGIT--------EEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTHTLLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR--LWPSLDRR-PALRLC >C5AR_CANFA SMNFSPPEYPDYG-TATLDPNIFVDESLNTPKLSVPDMIALVIFVMVFLVGVPGNFLVVWVTGFEVR-RTINAIWFLNLAVADLLSCLALPILFSSIVQQGYWPFGNAACRILPSLILLNMYASILLLTTISADRFVLVFNPICQNYRGPQLAWAACSVAWAVALLLTVPSFIFRGVHT-PF--MTCGVD-YSGVGVLVERGVAILRLLMGFLGPLVILSICYTFLLIRT---------WSRKATRSTKTLKVVVAVVVSFFVLWLPYQVTGMMMALFYKHRRVSRLDSLCVAVAYINCCINPIIYVLAAQGFHSRFLKSLPARLRQVLAEESVGRSTVD-------- >CKRA_HUMAN QVSWGHYSGDEEDAYSAEPLPELC---YKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRARSPTSAHLLQLALADLLLALTLPFAAAGALQG--WSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALGPRPSTPGRAHLVSVIVWLLSLLLALPALLFS--QD-RE-QRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTL---------LAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSSPSGPQPRRGC--------PRLS >MTR_BUFMA LNLDCSELPNSSWVNSSMENQSSNSTRDPLKRNEEVAKVEVTVLALILFLALAGNICVLLGIYINRHKHSRMYFFMKHLSIADLVVAIFQVLPQLIWDITFRFYAPDLVCRLVTYLQVVGMFASTYMLLLMSLDRCLAICQPL--RSLHRRSDCVYVLFTWILSFLLSTPQTVIFSLTE----VYDCRAD---FIQPWGPKAYITWITLAVYIIPVMILSVCYGLISYKIWQNRATVSSVRLISKAKIRTVKMTFIIVLAYIVCWTPFFFVQMWSVWDPNP-KEASLFIIAMLLGSLNSCCNPWIYMLFTGHLFHDLLQSFLCCSARYLKTQQQGSSNSSTFVLSRKS >B1AR_HUMAN LPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQGLLCCARRAARRRHATHGCLARPGPPPSPG >ACM2_RAT --------------MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVSRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VE-DGECYIQ------FFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >AG22_MERUN AATSRNITSSLPFVNLNMSGTNDLIFNCSHKPSDKHLEAIPVLYYLIFVIGFAVNIIVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRT-LG--NACVMAFPPEKYAQWSAGIALMKNVLGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALSWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSMFRVPITWLQGKRETMSREMDTFVS---- >NY5R_PIG -------------NTVATRNSGFPVWEDYKGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMRKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVTVLVSTLILISIAIVRYHMIKHPV-SNNLTANHGYFLIATVWTLGLAICSPLPVFHSLVESS--RYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRTISCGVPESRSIMRLRKRSRSVFYRLTVLILVFAVSWMPLHLFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLMSLIHCLHVS--------------------- >CB1R_HUMAN EFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHR-KDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCE-K--LQSVCSDI------FPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGKHANNAASVHRA >D3DR_MOUSE --------MAPLSQISSHINSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN---D-P--SICSI---------SNPDFVIYSSVVSFYVPFGVTVLVYARIYMVLRQRTSLPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------- >GPRF_MACMU ----MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPLKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKLLAIVSGLQAMLQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFT >CB1R_RAT EFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCK-K--LQSVCSDI------FPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGHANNTASMHRAA >CKR4_HUMAN IADTTLDESIYSNYYLYESIPKPC---TKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQ--WVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT-ER-HTYCKTK-YSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTL---------QHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLTP------SSSY >PD2R_MOUSE ----------------------MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQ-MIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMAQSYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKL--AEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQL----------- >OPSD_BUFMA MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLCAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTVTMYSSMNGYFVFGQTGCYVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFSENHAIMGVAFTWIMALACAAPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVFFLICWVPYASVAFFIFTHQGSEFGPVFMTIPAFFAKSSSIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDEDASSAASSVSSSQVSPA >5H1F_MOUSE -------------MDFLNASD-QNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVYARKRTPRHAGIMITIVWVISVFISMPPLFWR----S-R--DECVIK-------HDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLLKHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRY----------------------- >B2AR_RAT MEPHGNDSDFLLAPNGSRAPGH----DITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-D--TCCDFF--------TNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQGRSLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANL-IPKEVYILLNWLGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSSKTYGNGYSDYTGEQSAYQLG >O.YR_PIG GVLAANWSAEAVNSSAAPPEAEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RALRRPADRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDADA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSSSHLKTSRPGENSSTFVLSQHSS >OPSB_CARAU PEFHEDFYIPIPLDINNLSAYSPFLVPQDHLGNQGIFMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFVAIFGSPLSFYSFFNRYFIFGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGNFTFKTPHAIAGCILPWISALAASLPPLFGWSRYIPEGLQCSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSASTQKAEREVTKMVVVMVLGFLVCWAPYASFSLWIVSHRGEEFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMMKMVCGKNIEE---DEASTSSVAPEK----- >5H1B_RAT CAPPPPATSQTGVPLANLSHNSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPKRAAIMIVLVWVFSISISLPPFFWR----E-E--LDCFVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG--------------------- >H963_HUMAN -----------------------MTNSSFFCPVYKDLEPFTYFFYLVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCIYRIQEPGFAKMISTVVWLMVLLIMVPNMMIPIKD-SN---VGCMEF--KKEFGRNWHLLTNFICVAIFLNFSAIILISNCLVIRQLYR-----NKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRSKVTETFASPKETKAQKEKLRC------------ >OPS3_DROME ARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVKTPIFIYNSFHQG-YALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPM-EGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFPEGYLTSCTFD--YLTDNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHNVESNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLALNEKAPESSAVEPQQTTAA---- >CCR5_MOUSE DDLYKELAFYSNSTEIPLQDSNFCSTVEGPLLTSFKAVFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLLVFILPFAVAEGSVG--WVLGTFLCKTVIALHKINFYCSSLLVACIAVDRYLAIVHAVAYRRRRLLSIHITCTAIWLAGFLFALPELLFAKVGQ-ND-LPQCTFSQENEAETRAWFTSRFLYHIGGFLLPMLVMGWCYVGVVHRL--------LQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLERLKGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCAG---PASLC--------PNWR >5H1F_CAVPO -------------MDFLNSSD-QNLTSEELLHRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVYARKRTPKQAGIMITIVWIISVFISMPPLFWR----S-R--DECIIK-------HDHIVSTIYSTFGAFYIPLVLILILYYKIYKAAKTLLRHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMANFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCQY----------------------- >OPSD_MESBI MNGTEGLNFYVPFSNHTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVANLFMVLGGFTTTLYTSMHAYFIFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWIMALACAAPPLVGWSRYIPEGMQCSCGVDYYTPSPEVNNESFVVYMFVVHFSIPMVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVVIMVVAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPSFFAKSSAIYNPVIYIMMNKQFRNCMLTTLCCGRNPLGDDEVSTTASKTETSQVAPA >PI2R_RAT GRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYYAQLDGPRCARLALPAIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIR---MRSPQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLCHMRRHFVPTSRAREDEVYHLILLALMTGIMAVCSLPLTIRGFTQAIAPDS--REMGDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQTPRRDTLAPDSLQA >IL8A_PANTR PQMWDFDDLNFTGMPPTDEGYSPC----RLETETLNKYVVIITYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYH-NS-SPVCYEV-LGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHR------------ >CCR5_HUMAN EDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVG--WVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQ-NN-LPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRL--------RQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTG---PASLC--------PSWR >CB2R_HUMAN ----MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHG-VDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTC-----CPRPCSEL------FPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHSGHQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKVTETEADGKITP >AA2B_HUMAN ------------------------------MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLG--FCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDT-T-LVKCLFE-----NVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQ---MDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGLGVGL------- >MSHR_HUMAN AVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGTNVLETAVILLLEAAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALYHSIVTLPRAPRAVAAIWVASVVFSTLFIAYYY----------------------DDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHIARKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW----------------------- >ETBR_PIG SSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITRI--LRICLLHQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFE-EKQSLEFKANDHGYDNFR >OAR2_LOCMI SSAAEEPQDALVGGDACGGRRPPSVLGVRLAVPEWEVAVTAVSLSLIILITIVGNVLVVLSVFTYKPLRIVQNFFIVSLAVADLTVAVLVMPFNVAYSLIQRWVFGIVVCKMWLTCDVLCCTASILNLCAIALDRYWAITDPIYAQKRTLRRVLAMIAGVWLLSGVISSPPLIGWNDW-N-D--TPCQLT--------EEQGYVIYSSLGSFFIPLFIMTIVYVEIFIATKRRPVYEEKQRISLSKERRAARTLGIIMGVFVVCWLPFFLMYVIVPFCNPSKPSPKLVNFITWLGYINSALNPIIYTIFNLDFRRAFKKLLHFKT----------------------- >MC5R_HUMAN -MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNDAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALYHHIMTARRSGAIIAGIWAFCTGCGIVFILYYS----------------------EESTYVILCLISMFFAMLFLLVSLYIHMFLLARTH-RIPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD------------ >5H6_RAT -----------MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPARNTS-NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLYKLRMTAPRALALILGAWSLAALASFLPLLLGWH---E-APGQCRLL--------ASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQMESRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPAVPDQASACSRC >5H1D_CAVPO SPPNQSEEGLPQEASNRSLNATETPGDWDPGLLQALKVSLVVVLSIITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAGAMIAAVWVISICISIPPLFWR----Q-E--SDCLVN-------TSQISYTIYSTCGAFYIPSVLLIILYSRIYRAARSRKLALERKRISAARERKATKTLGIILGAFIVCWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQKVVHFRKAS--------------------- >NMBR_MOUSE SNLSFPTEANESELVPEVWEKDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLTNSAMRNVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMMQTSGVLLWTSLKAVGIWVVSVLLAVPEAVFSEVARSS--FTACIPY---QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIKSLPGNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHVLYLYRSFNYKELGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGRKSYPERSTSYLMTSLKSNTKNVV >OPSD_SHEEP MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPQGMQCSCGALYFTLKPEINNESFVIYMFVVHFSIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQFRNCMLTTLCCGKNPLGDDEASTTVSKTETSQVAPA >OPSD_GALML MNGTEGENFYVPMSNKTGVVRNPFEYPQYYLADHWMFAVLAAYMFFLIITGFPVNFLTLFVTIQNKKLRQPLNYILLNLAVANLFMVFGGFTTTLITSMNGYFVFGSTGCNLEGFFATLGGEISLWSLVVLAIERYVVVCKPMSNFRFGSQHAIAGVSLTWVMAMACAAPPLVGWSRYIPEGLQCSCGIDYYTPKPEINNVSFVIYMFVVHFSIPLTIIFFCYGRLVCTVKAAAAQQQESETTQRAEREVTRMVVIMVIGFLICWLPYASVALYIFNNQGSEFGPVFMTIPSFFAKSSALYNPLIYILMNKQFRNCMITTLCCGKNPFEEEESTSASSVSSSQVSPAA >A1AA_RAT ----------MVLLSENASEGSNCT-HPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKREAKNFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALSQ---------- >GHSR_RAT SEEPEP-NVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVG---T-D-TNECRAT---FAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRD--AVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDKSSINT------ >O1E2_HUMAN -------------MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPVYLFLSNLSFSDLCFSSVTMPKLLQNMQNQDPSIPYADCLTQMYFFLYFSDLESFLLVAMAYDRYVAICFPMYTAIMSPMLCLSVVALSWVLTTFHAMLHTLLMARL---CPHFFCDMSKLACSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSI--------LKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCPSANS---STLKDTVMAMMYTVVTPMLTPFIYSLRNRDMKGALERVICKRKNPFLL------------------ >OPSD_SARSL MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYARLGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMALACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFTVPLMVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVVAFLVCWLPYASVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >DOP2_DROME SATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARP----YKCTFT--------EHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQMGKLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTFATRRCYSTCSL >GASR_RABIT VASLCRPGGPLLNNSGTGNLSCEPPRIRGAGTRELELAIRVTLYAVIFLMSVGGNILIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTAVQP---V-LQCVHR---WPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGSGPPRPAQAKLLAKKRVVRMLLVIVVLFFMCWLPVYSANTWRAFDGPGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPSIASLSRLSYT >IL8B_CANFA G--DIDNYTYNTEMPIIPADSAPC----RPESLDINKYAVVVIYVLVFVLNLLGNSLVIMVVLYSRVSHSVTDVYLLNLAIADLLFALTLPIWAVSKVKG--WIFGTPLCKIVSLLKEVNFYSGILLLASISMDRYLAIVHATRRLTQKKHWVKFICLGIWALSLILSLPIFVFRRAIN-YS-SPVCYED-MGTNTTKLRIVMRALPQTFGFIVPLMIMLFCYGLTLRTL---------FEAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVADTLMRLQAINDIGRALDATEILGFFHSCLNPLIYAFIGQKFRHGLLKIMAFHGLISKEYLPKDS------------ >KI01_RAT ---------------MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPS-SKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQS-TN---IQCMEL--KNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFK----LKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS-------------------------------- >O18793 RSRFIRNTNGSGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSLTDIYLLNLAISDLLFLITLPLWAHSAANE--WVFGNAMCKLFTGLYHIGYLGGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQE-ED-VYICGPY----FPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWTPYNIVILLNTFQEFFRQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSMFFRKYITKRFCKQCPVFVTSTNTPSTAEQ >NY1R_HUMAN TLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDKD--KYVCFDQ---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >B2AR_FELCA ----MGQPGNRSVFLLAPNGSHAPDQDGTQERNDAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQDGRHRRASKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWVGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGYSDYAGEHSGGPLG >OLF1_RAT -------------MTEENQTVISQFLLLFLPIPSEHQHVFYALFLSMYLTTVLGNLIIIILIHLDSHLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSIPFAGCLTQLYFYLYFADLESFLLVAMAYDRYVAICFPLYMSIMSPKLCVSLVVLSWVLTTFHAMLHTLLMARL---SPHFFCDISKLSCSDTHVNELVIFVMGGLVIVIPFVLIIVSYARVVASI--------LKVPSVRGIHKIFSTCGSHLSVVSLFYGTIIGLYLCPSANN---STVKETVMAMMYTVVTPMLNPFIYSLRNRDMKEALIRVLCKKKITFCL------------------ >GASR_HUMAN GASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQP---V-LQCVHR---WPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGPGPSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPSIASLSRLSYT >CKR2_MOUSE FTRSIQELDEGATTPYDYDDGEPC---HKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQ-DD-HYTCGPY----FTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFV-------SSTF >CKRA_MOUSE PTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTRSPTSVHLLQLALADLLLALTLPFAAAGALQG--WNLGSTTCRAISGLYSASFHAGFLFLACINADRYVAIARALGQRPSTPSRAHLVSVFVWLLSLFLALPALLFS--RD-RE-QRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTL---------LAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCSCSAPTETHSLS >OPSD_GOBNI MNGTEGPFFYIPMVNTTGVVRSPYEYPQYYLVNPAAYACLGAYMFFLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMASACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFTVHFCIPLAVVGFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVIGFLVCWLPYASVAWYIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTVSSSSVSPAA-- >AG2R_PIG ------MILNSSTEDSIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFH-YESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSE-------N >BONZ_MACMU -----MAEYDHYEDDGFLNSFNDSSQEEHQDFLQFRKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WIFGQVMCKTLLGVYTINFYTSMLILTCITVDRFIVVVKATNQQAKRMTWGKVICLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DEEISTVVLATQMTLGFFLPLLAMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQTPFNLVKLIRSTHWEYTSFHYTIIVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >PE24_RABIT --------------------MSTPVANASASSMPELLNNPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSRLQFPDTWCFID---WRTNVTAHAAFSYMYAGFSSFLILATVLCNVLVCGALLRMAAAAASFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPDEISQNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRDRSRRTSSAMSTHSR >FSHR_MACFA FDMTYAEFDYDLCNEVVDVTCSPKPDAFNPCEDILGYNILRVLIWFISILAITGNIIVLVTLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLDCKVHVRHAASVMVMGWIFAFAAALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTNSHPRNGHCSSA >ACM1_DROME -------------MYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGTISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIINFDRYFSVTRPLYRAKGTTNRAAVMIG-AWGISLLLWPPWIYSWPYIE-VP-KDECYIQ-----FIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRNPNKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSCIPTELWDFFYALCYINSTINPMSYALCNATFRRTYVRILTCKWHTRNREGMVRG------------ >BRS3_MOUSE QTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTVT--FESCNSY---ISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSIPTQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIMGRVPATGSAHV >OPSD_MUGCE MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAVERWMVVCKPISNFRFGENHAIMGLAFTWVMASACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLICWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >C5AR_HUMAN SFNYTTPDYGHYDDKDTLDLNTPVD--KTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAK-RTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPICQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVRE-PP--VLCGVD-YS-HDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRT---------WSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSLLLNKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRSTVD-------- >MAS_RAT ------MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMR-RNPFTVYITHLSIADISLLFCIFILSIDYALDYESSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCI-DSHS--QSDC-----------RAVIIFIAILSFLVFTPLMLVSSTILVVKIRK----------NTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYW--STFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRTVSIETVV---- >GPRC_RAT NLSGLPRDCIEAGTPENISAAVPSQGSVVESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAG-LGLIINFVFA-Y--LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALYHSERTVTFTYVMLVMLWGTSTCLGLLPVMGWNCL-R--DESTCSVV-------RPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHIALHFLATSHYVTTRKGISTLALILGTFAACWMPFTLYSLIADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPNTLSQRARSP------------ >V1AR_HUMAN SSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIETK--ARDCWAT---FIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNFLLVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTTFYSNNRSPTNS >A1AA_HUMAN ----------MVFLSGNASDSSNCT-QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKREAKTFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALSQ---------- >CML2_RAT PSNSTPLALNLSLALREDAPGNLTGDLSEHQQYVIALFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAAADLILVADSLIEVFNLDEQ--YYDIAVLCTFMSLFLQINMYSSVFFLTWMSFDRYLALAKAMCGLFRTKHHARLSCGLIWMASVSATLVPFTAVHLR-A----CFCFA---------DVREVQWLEVTLGFIVPFAIIGLCYSLIVRALIR----AHRHRGLRPRRQKALRMIFAVVLVFFICWLPENVFISVHLLQWAQHAYPLTGHIVNLAAFSNSCLSPLIYSFLGETFRDKLRLYVAQKTSLPALNRFCHADSTEQSDVKFSS >GPRF_HUMAN ----MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPIKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFA >CKR5_TRAFR ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >GP68_HUMAN ----------------MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEV--QH---RVCFEHPIQAWQRAIQRAINYYRFLVGFLFPICLLLASYQGILRAVRR------SHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAAPEASGKSGAQG >YYI3_CAEEL SDPNAEDLYITMTPSVSTENDTTVWATEEPAAIVWRHPLLAIALFSICLLTVAGNCLVVIAVCTKKYIWVTRLYLIISLAIADLIVGVIVMPMNSLFEIANHWLFGLMMCDVFHAMDILASTASIWNLCVISLDRYMAGQDPIYRDKVSKRRILMAILSVWVLSAILSFPGIIWWWRTSP-H--SQCLFT--------DSKMYVSFSSLVSFYIPLFLILFAYGKVYIIATRHKLNKSRQMMRYVHEQRAARTLSIVVGAFILCWTPFFVFTPLTAFCESCSNKETIFTFVTWAGHLNSMLNPLIYSRFSRDFRRAFKQILTCQRQQKVKTAFKTPLISVTQMAPRFS >CKR1_MACMU METPNTTEDYDMITEFDYGDATPC---HKVNERAILAQLLPPLYSLVFVIGVVGNLLVVLVLVQYKRLKNMTNIYLLNLAISDLLFLFTLPFLIYYKSTDD-WIFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIIIWALAILASSPLMYFSKTQW-NI-RHSCNIHFPYESFQQWKLFQALKLNLFGLVLPLLVMIVCYTGIIKIL---------LRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTELISVFQEFLRQLDLAMEVTEVIANMHCCVNPVIYAFAGERFRKYLRQLFHRRVAVHLVKWLPFLV-------SSTS >BRB2_RAT IEMFNITTQALGSAHNGTFSEVNC---PDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKD-HN--TACVIV---YPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNN---EMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGRAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQLRTS-------I >A1AD_RAT TGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEP--VP--RFCGIT--------EEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTHTLLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR--LWAASTGD-ARSDCA >TSHR_BOVIN LQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNP------HYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGSTGIRVQKVPPD >MC3R_HUMAN NASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEIFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYYS----------------------EESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHIAAADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG------------------ >MSHR_SHEEP PVLGSQRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSVLSITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >CKR1_MOUSE MEISDFTEAYPTTTEFDYGDSTPC---QKTAVRAFGAGLLPPLYSLVFIIGVVGNVLMILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDD-WIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVALRARTVTLGIITSIITWALAILASMPALYFFKAQW-EF-HRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRIL---------LRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLKHLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLT-------SSIS >A2AA_BOVIN ----MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRP-S--PRCEIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRSGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCP--VPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >SSR3_MOUSE SEPMTLDPGNTSSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTSARWRTAPVARTVSRAVWVASAVVVLPVVVFSGVPR-----STCHMQ-WPEPAAAWRTAFIIYMAALGFFGPLLVICLCYLLIVVKVRSTSCQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGEEDEEEEERREE >P2YR_BOVIN TAFLADPGSPWGNSTVTSTAAVASPFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAVYISVLVWLIVVVGISPILFYSGTG----KTITCYDT-TSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLSEFKQNGDTSL >5H5B_RAT TPGIAFPPGPESCSDSPSSGRGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLYTLRTRRRASALMIAITWALSALIALAPLLFGWGE-D-A-LQRCQVS--------QEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRATVTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCAC-SLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR----------------------- >OPSD_CHICK MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLGGEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSRYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQFRNCMITTLCCGKNPLGDEDTSAGTSSVSTSQVSPA >B3AR_MOUSE MAPWPHRNGSLALWSDAPTLDPSAAN---TSGLPGVPWAAALAGALLALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVQ-E--RCCSFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQGVPRRPARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPS-VPSGVFIALNWLGYANSAFNPVIYCRSP-DFRDAFRRLLCSYGGRGPEEPRAVTARQSPPLNRFDG >SSR1_RAT GEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAADG--TVACNML-MPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQ--DDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLS-----WMDNAAETALKSRAYSVED >AA1R_HUMAN ----------------------------MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPID--PDD--------- >PE23_HUMAN PFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHYASHMKTRATRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCWSDHLER----- >OLF0_RAT ---------------MNNQTFITQFLLLGLPIPEEHQHLFYALFLVMYLTTILGNLLIIVLVQLDSQLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMRSQDTSIPYGGCLAQTYFFMVFGDMESFLLVAMAYDRYVAICFPLYTSIMSPKLCTCLVLLLWMLTTSHAMMHTLLAARL---SLNFFCDLFKLACSDTYINELMIFIMSTLLIIIPFFLIVMSYARIISSI--------LKVPSTQGICKVFSTCGSHLSVVSLFYGTIIGLYLCPAGNN---STVKEMVMAMMYTVVTPMLNPFIYSLRNRDMKRALIRVICSMKITL-------------------- >BRB2_RABIT -MLNITSQVLAPALNGSVSQSSGC---PNTEWSGWLNVIQAPFLWVLFVLATLENLFVLSVFCLHKSSCTVAEVYLGNLAAADLILACGLPFWAVTIANHFDWLFGEALCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMIGRMRRVRWAKLYSLVIWGCTLLLSSPMLVFRTMKD-YN--TACIID---YPSRSWEVFTNVLLNLVGFLLPLSVITFCTVQILQVLRNN---EMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQVSTFLDTLLKLGHVIDVITQVGSFMGYSNSCLNPLVYVIVGKRFRKKSREVYRAACPKAGCVLEPVQLRTS-------I >CCKR_MOUSE DSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTANMCRFL---LPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGRINSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVTIRASLSRYSYS >ACM3_RAT N---------ISQETGNFSS-NDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQHKRVPEQAL--- >5H1E_HUMAN -------------MNITNCT--TEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIYARKRTAKRAALMILTVWTISIFISMPPLFWRS---S-P--SQCTIQ-------HDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLNDLGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYT-VSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT--------------------- >OPS1_CALVI ALT---NGSVTDKVTPDMAHLVHPYWNQFPAMEPKWAKFLAAYMVLIATISWCGNGVVIYIFSTTKSLRTPANLLVINLAISDFGIMITNTPMMGINLFYETWVLGPLMCDIYGGLGSAFGCSSILSMCMISLDRYNVIVKGMAGQPMTIKLAIMKIALIWFMASIWTLAPVFGWSRYVPEGNLTSCGID--YLERDWNPRSYLIFYSIFVYYLPLFLICYSYWFIIAAVSAHMNVRSSEDADKSAEGKLAKVALVTISLWFMAWTPYTIINTLGLFKYEG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYGIALKEKCPCCVFGKVDDGK-ASNNESETKA---- >V1BR_RAT ---MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLGRHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLRESG--VLDCWAD---FYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNRGLVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENADSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGSKPQVHRQLSRTTLLTHACGSP >OPSD_SARPI MNGTEGPFFYIPMSNATGLVRSPYDYPQYYLVPPWGYACLAAYMFLLILTGFPVNFLTLYVTIEHKKLRSPLNYILLNLAVADLFMVIGGFTTTMWTSLNGYFVFGRMGCNIEGFFATLGGEIALWSLVVLSMERWIVVCKPISNFRFGENHAVMGVAFSWFMAAACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVVHFTCPLTIITFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVIIMFVAFLACWVPYASVAWYIFTHQGSEFGPVFMTIPAFFAKSSAVYNPVIYICLNKQFRHCMITTLCCGKNPFEEEEGSTTSVCSVSPAA--- >V1BR_MOUSE ---MDSEPSWTATPSPGGTLFVPNTTTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLILGLQGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPSQSTYPLIAAPWLLAAILSLPQVFIFSLRESG--VLDCWAD---FYFSWGPRAYITWTTMAIFVLPVVVLTACYGLICHEIYKNATLVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENADSTNVAFTISMLLGNLSSCCNPWIYMGFNSHLLPRSLSHRACCRGSKPRVHRQLSRTTLLTHTCGPS >CCKR_CAVPO DSLFVNGSNITSACELGFENETLFCLDRPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPSLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTGNMCRFL---LPNDVMQQTWHTFLLLILFLIPGIVMMVAYGLISLELYQGRINSSSSTANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGTPGVRGEMTTGASLSRYSYS >OPRM_RAT LSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVPSTANTVDRTNH >FMLR_RABIT -----------MDSNASLPLNVSGGTQATPAGLVVLDVFSYLILVVTFVLGVLGNGLVIWVTGFRMT-HTVTTISYLNLALADFSFTSTLPFFIVTKALGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCICVLHPVAQNHRNVSLAKKVIVGPWICALLLTLPVIIRVTTLSSPWPAEKLKVA------ISMFMVRGIIRFIIGFSTPMSIVAVCYGLIATKI---------HRQGLIKSSRPLRVLSFVVASFLLCWSPYQIAALIATVRIREKDLRIVLDVTSFVAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALSEDSAQTTS---------- >OPSP_COLLI ----MDPTNSPQEPPHTSTPGPFDGPQWPHQAPRGMYLSVAVLMGIVVISASVVNGLVIVVSIRYKKLRSPLNYILVNLAMADLLVTLCGSSVSFSNNINGFFVFGKRLCELEGFMVSLTGIVGLWSLAILALERYVVVCRPLGDFRFQHRHAVTGCAFTWVWSLLWTTPPLLGWSSYVPEGLRTSCGPN--WYTGGSNNNSYILTLFVTCFVMPLSLILFSYANLLMTLRAAAAQQQESDTTQQAERQVTRMVVAMVMAFLICWLPYTTFALVVATNKDIAIQPALASLPSYFSKTATVYNPIIYVFMNKQFQSCLLKMLCCGHHPRGTGRTAPAGLRNKVTPSHPV >O1D2_HUMAN -------------MDGGNQSEGSEFLLLGMSESPEQQQILFWMFLSMYLVTVVGNVLIILAISSDSRLHTPVYFFLANLSFTDLFFVTNTIPKMLVNLQSHNKAISYAGCLTQLYFLVSLVALDNLILAVMAYDRYVAICCPLYTTAMSPKLCILLLSLCWVLSVLYGLIHTLLMTRV---THYIFCEMYRMACSNIQINHTVLIATGCFIFLIPFGFVIISYVLIIRAI--------LRIPSVSKKYKAFSTCASHLGAVSLFYGTLCMVYLKPLHTY----SVKDSVATVMYAVVTPMMNPFIYSLRNKDMHGALGRLLDKHFKRLT------------------- >IL8A_HUMAN PQMWDFDDLNFTGMPPADEDYSPC----MLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYH-NS-SPVCYEV-LGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHR------------ >EBP2_HUMAN NPDKDGGTPDSGQELRGNLTGQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQM----KPSASLSLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPRKS-CRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTEQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASKLKTEVSSSIYF >5H5B_MOUSE TPGLAFPPGPESCSDSPSSGRGGLILPGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAVLVMPLSLVSELSAGWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLYTLRTRSRASALMIAITWALSALIALAPLLFGWGE-D-A-LQRCQVS--------QEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRATVTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELISPLCAC-SLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR----------------------- >V2R_BOVIN MFMASTTSAVPWHLSQPTPAGNGSEGELLTARDPLLAQAELALLSTVFVAVALSNGLVLGALVRRGRRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAHRHGGGTHWNRPVLLAWAFSLLFSLPQLFIFAQRDSG--VLDCWAR---FAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASGCRPAEGARVSAAVAKTVKMTLVIVIVYVLCWAPFFLVQLWAAWDPEA-REGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCTWRRAPPSPGPQESFLAKDTPS--- >GRHR_MOUSE --MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPL-AVQSNSKLEQSMISLAWILSIVFAGPQLYIFRMIYTV--FSQCVTH--SFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVPRKNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >OLF1_CANFA --------------MDGNYTLVTEFILLGFPTRPELQIVLFLVFLTLYGIILTGNIGLMMLIRTDPHLQTPMYFFLSNLSFADLCFSSAIVPKMLVNFLSENKSISLYGCALQFYFSCAFADTESFILAAMAYDRYVAICNPLYTVVMSRGICVWLIVLSYIGGNMSSLVHTSFAFIL---KNHFFCDLPKLSCTDTSVNEWLLSTYGSSVEIFCFIVIVISYYFILRSV--------LRIRSSSGRKKTFSTCASHLTSVAIYQGTLLFIYSRPTYLY---TPNTDKIISVFYTIIIPVLNPLIYSLRNKDVKDAAKRAVRLKVDSS-------------------- >GPRY_HUMAN SVSSWPYSSHRMRFITNHSDQATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKK-----STMCFHY--RDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKR--SKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSLHDTSVAVKIQS >OPSD_RANPI MNGTEGPNFYIPMSNKTGVVRSPFDYPQYYLAEPWKYSVLAAYMFLLILLGLPINFMTLYVTIQHKKLRTPLNYILLNLGVCNHFMVLCGFTITMYTSLHGYFVFGQTGCYFEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIISFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWVPYAYVAFYIFTHQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDDDASSAATSVSTSQVSPA >GP38_HUMAN GSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLARVLVTRRRVRALIAVLWAVALLSAGPFLFLVG---AEAFSRECRPS----PAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSPLR--AASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDDTGGDTVGYTET >GPRM_HUMAN PILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPA-NRILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFS--TKTLLCVST---EYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRTISQHEARERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNWIDPKRNKKITF >GPR3_HUMAN GAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAG-LGLVLHFAAV-F--CIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCL-D--GLTTCGVV-------YPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHIALHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDA----HSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSP------------ >CCKR_RAT DSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTANMCRFL---LPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGRLNSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVTIRALLSRYSYS >RDC1_MOUSE YAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITTPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTTSSYKKKMVRRVVCILVWLLAFFVSLPDTYYLKAVTNNE--TYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAM---------SASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHNVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNTK-- >OLF9_RAT -------------MTRRNQTAISQFFLLGLPFPPEYQHLFYALFLAMYLTTLLGNLIIIILILLDSHLHTPMYLFLSNLSFADLCFSSVTMPKLLQNMQSQVPSIPYAGCLAQIYFFLFFGDLGNFLLVAMAYDRYVAICFPLYMSIMSPKLCVSLVVLSWVLTTFHAMLHTLLMARL---SPHYFCDMSKVACSDTHDNELAIFILGGPIVVLPFLLIIVSYARIVSSI--------FKVPSSQSIHKAFSTCGSHLSVVSLFYGTVIGLYLCPSANN---STVKETVMSLMYTMVTPMLNPFIYSLRNRDIKDALEKIMCKKQIPSFL------------------ >5H1D_RABIT SPSNQSAEGLPQEAANRSLNATGTPEAWDPGTLQALKISLAVVLSIITVATVLSNTFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQVLCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAAAMIAVVWAISICISIPPLFWR----H-E--SDCLVN-------TSQISYTIYSTCGAFYIPSVLLIVLYGRIYMAARNRKLALERKRISAARERKATKTLGIILGAFIGCWLPFFVASLVLPICRDSWMPPGLFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQRVIHFRKAF--------------------- >ML1C_.ENLA -----MMEVNSTCLDCRTPGTIRTEQDAQDSASQGLTSALAVVLIFTIVVDVLGNILVILSVLRNKKLQNAGNLFVVSLSIADLVVAVYPYPVILIAIFQNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLYDKLYNQRSTWCYLGLTWILTIIAIVPNFFVGS-LQYDP-IFSCTFA------QTVSSSYTITVVVVHFIVPLSVVTFCYLRIWVLVIQVHR-QDFKQKLTQTDLRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPFHKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEYKRILMSLLTPRLLFLDTSRSKPSPAVTNNNQ >SSR2_PIG LLNGSQPWLSSPFDLNGSVATANSSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDLNETTETQRTLL >NTR1_HUMAN EEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFAKTLMSRSRTKKFISAIWLASALLTVPMLFTMGEQN--SGGLVCTPT---IHTATVKVVIQVN-TFMSFIFPMVVISVLNTIIANKLTVMEHSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRK-RPSVSSNHTLSSNA >AG2R_CAVPO ------MILNSSTEDGIKRIQDDC---PKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTRPSD-------N >PE23_RABIT PFCTRLNHSYPGMWAP----EARGNLTRPPGPGEDCGSVSVAFPITMLITGFVGNALAMLLVSRSYRRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSKQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHYASHMKTRATRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNGTSSSHNWGNLFFASTFAFLGLLALAITFTCNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVIHENNEQKDEIQRENRHEEARDSEKSKT >CB1A_FUGRU TDLFGNRNTTRD-ENSIQCGENFMDMECFMILTPSQQLAVAVLSLTLGTFTVLENLVVLCVIFQSRTRCRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHK-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYRRIVTRTKAVIAFCMMWTISIIIAVLPLLGWNCK-R--LNSVCSDI------FPLIDENYLMFWIGVTSVLVLFIIYAYIYILWKAHHHAEGQTTRPEQTRMDIRLAKTLVLILAVLVICWGPLLAIMVYDLFWKMDDNIKTVFAFCSMLCLLNSTVNPIIYALRSRDLRHAFLSSCHACRGSAQQLDNSLENVN--ISANRAA >CKR9_HUMAN DDYGSESTSSMEDYVNFNFTDFYC---EKNNVRQFASHFLPPLYWLVFIVGALGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLVTLPFWAIAAADQ--WKFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIAQAMTWREKRLLYSKMVCFTIWVLAAALCIPEILYSQIKE-G--IAICTMVYPSDESTKLKSAVLTLKVILGFFLPFVVMACCYTIIIHTL---------IQAKKSSKHKALKVTITVLTVFVLSQFPYNCILLVQTIDAYATNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFT--------GSLK >V1BR_HUMAN ---MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLRESG--VLDCWAD---FGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNRGLVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNADSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSHTTLLTRSSCPA >5H4_RAT ------------------MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIRK-NSTFCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHSRPDQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTINGSTHVLR-- >5HTA_DROME DSSLFGEMLANRSGHLDLINGTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNI-YIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDE-Q--QKCMVS--------QDVSYQVFATCCTFYVPLMVILALYWKIYQTARKRPMQKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL------------- >HH1R_CAVPO -MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFM--EP-EKKCETD------FYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHLRSQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSC-SNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP----------------------- >OPSD_PHOGR MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVGLTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGFNFGPIFMTLPAFFAKAAAIYNPVIYIMMNKQFRTCMITTLCCGKNPLGDDEVSASASKTETSQVAPA >MSHR_CANFA VWQGPQRRLLGSLNGTSPATPHFELAANQTGPRCLEVSIPNGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYY----------------------NNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQH-IAKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSWA---------------------- >A2AC_HUMAN AAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKRRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFIYSLYGICREAQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRPSFKHILFRRRRRGFRQ----------------- >B1AR_SHEEP VPDGAATAARLLVP-SPLRLAADLGQRGTPLLSQQWTVGMGLLMAFIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPIFMQWWGDS-R--ECCDFI--------INEGYAITSSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACGSHGAAGCLAVARPSPSPG >OPS4_DROME S-GNGDLQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLKAPIFNSFHRGFA-IYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPM-NRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFPEGYLTSCSFD--YLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHNVESNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGVNEKSGEISSAQQQTTAA----- >O1E1_HUMAN -------------MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPMYLFLSNLSFSDLCFSSVTIPKLLQNMQNQDPSIPYADCLTQMYFFLLFGDLESFLLVAMAYDRYVAICFPLYTAIMSPMLCLALVALSWVLTTFHAMLHTLLMARL---CPHFFCDMSKLAFSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSI--------LKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCSSANS---STLKDTVMAMMYTVVTPMLNPFIYSLRNRDMKGALSRVIHQKKTFFSL------------------ >MSHR_CHICK -MSMLAPLRLVREPWNASEGNQSNATAGAGGAWCQGLDIPNELFLTLGLVSLVENLLVVAAILKNRNLHSPTYYFICCLAVSDMLVSVSNLAKTLFMLLMEHASIVRHMDNVIDMLICSSVVSSLSFLGVIAVDRYITIFYALYHSIMTLQRAVVTMASVWLASTVSSTVLITYYY----------------------RRNNAILLCLIGFFLFMLVLMLVLYIHMFALACHHSISQKQPTIYRTSSLKGAVTLTILLGVFFICWGPFFFHLILIVTCPTNTCFFSYFNLFLILIICNSVVDPLIYAFRSQELRRTLREVVLCSW----------------------- >A1AA_BOVIN ----------MVFLSGNASDSSNCT-HPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKREAKNFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLSH---------- >CKR5_PYGBI ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCYIFA-------SSVY >OPSO_SALSA TLRIAVNGVSYNEASEIYKPHADPFTGPITNLAPWNFAVLATLMFVITSLSLFENFTVMLATYKFKQLRQPLNYIIVNLSLADFLVSLTGGTISFLTNARGYFFLGNWACVLEGFAVTYFGIVAMWSLAVLSFERYFVICRPLGNVRLRGKHAALGLLFVWTFSFIWTIPPVFGWCSYTVSKIGTTCEPN--WYSNNIWNHTYIITFFVTCFIMPLGMIIYCYGKLLQKLRKVSHD--RLGNAKKPERQVSRMVVVMIVAYLVGWTPYAAFSIIVTACPTIYLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQVSTQLNWGFWSRA----------------------- >NY1R_RAT TLFSRVENYSVHYNVSE-NSPFLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDKD--KYVCFDK---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMIRDSKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >OLF3_CANFA -------------MGTGNQTWVREFVLLGLSSDWDTEVSLFVLFLITYMVTVLGNFLIILLIRLDSRLHTPMYFFLTNLSLVDVSYATSIIPQMLAHLLAAHKAIPFVSCAAQLFFSLGLGGIEFVLLAVMAYDRYVAVCDPLYSVIMHGGLCTRLAITSWVSGSMNSLMQTVITFQL---PDHISCELLRLACVDTSSNEIAIMVSSIVLLMTPFCLVLLSYIQIISTI--------LKIQSTEGRKKAFHTCASHLTVVVLCYGMAIFTYIQPRSSP---SVLQEKLISLFYSVLTPMLNPMIYSVRNKEVKGAWQKLLGQLTGITSKLAT--------------- >P2Y9_HUMAN DRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRH-WPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTN----ATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKP----ATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQRFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTIQEEVSDQTTNN >MC5R_BOVIN -MNSSFHLHFLDLGLNTTDGNLSGLSVQNASSLCEDMGIAVEVFLALGLISLLENILVIGAIVRNRNLHTPMYFFVGSLAVADMLVSLSNSWETITIYLLTNDASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCALYQRIMTGRRSGAIIGGIWAFCASCGTVFIVYYY----------------------EESTYVVICLIAMFLTMLLLMASLYTHMFLLARTH-RIPGHSSVRQRTGVKGAITLAMLLGVFIVCWAPFFLHLILMISCPHNSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQSFRTPCRFPSRY------------ >CKR5_TRAPH ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OPSB_SAIBB --MSKMPEEEEFYLFKNISSVGPWDGPQYHIAPVWAFQLQAAFMGIVFLAGLPLNSMVLVATVRYKKLRHPLNYVLVNVSVGGFLLCIFSVLPVFVNSCNGYFVFGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALMVVLTTWTIGIGVSIPPFFGWSRYIAEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLICFSYAQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAALAMYMVNNRNHGLDLRLVSIPAFFSKSSCIYNPIIYCFMNKQFRACIMEMVCGKAMTD---ESDISSTVSSSQVGPN- >OAR_DROME LSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPIYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDW-T-S--TPCELT--------SQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRGVNEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN------------------------ >PAR3_HUMAN -WTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTR-SICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYY--D--TTCHDVNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTL----------NAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK-------------------------- >NMBR_HUMAN SNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARSS--FTACIPY---QTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSLPGNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNELGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLMTSLKSNAKNMV >AA1R_BOVIN ----------------------------MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PRTYFHTCLKVACPVLILTQSSILALLAMAVDRYLRVKIPLYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSN-G-VIECQFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPID--PDD--------- >C.C1_MOUSE ----------MESSTAFYDYHDKLSLLCENNVIFFSTISTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLISAQWS---WFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPITLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVIS-----LNCKYS------EHHGFLASVYQHNIFFLLSMGIILFCYVQILRTL---------FRTRSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKTGIIQQQQLDIAMIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTSSTVPCEGPSFY------ >OPS1_PATYE NGTLNRSMTPNTGWEGPYDMSVHLHWTQFPPVTEEWHYIIGVYITIVGLLGIMGNTTVVYIFSNTKSLRSPSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHQWIFGSLFCQLYGFVGGVFGLMSINTLTAISIDRYVVITKPLASQTMTRRKVHLMIVIVWVLSILLSIPPFFGWGAYIPEGFQTSCTFD--YLTKTARTRTYIVVLYLFGFLIPLIIIGVCYVLIIRGVRRHSMKARANNKRARSELRISKIAMTVTCLFIISWSPYAIIALIAQFGPAHWITPLVSELPMMLAKSSSMHNPVVYALSHPKFRKALYQRVPWLFCCCKPKEKADFRSVTRTESVNSD >5H2B_MOUSE ILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIANQCNTRATAFIKITVVWLISIGIAIPVPIKGIET-NP---VTCELT------KDRFGSFMVFGSLAAFFVPLTIMVVTYFLTIHTLQKKRRMGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKGNSMVENSKFFT >OPSG_HUMAN DSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDG-----SELVSSV--SSVSPA >ACM4_MOUSE ------MANFTPVNGSSANQSVRLVTTAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-VP-DNQCFIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR---------------- >AA1R_RAT ----------------------------MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPID--AED--------- >AA1R_CHICK ----------------------------MAQSVTAFQAAYISIEVLIALVSVPGNILVIWAVKMNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIG--PQTEFYSCLMMACPVLILTESSILALLAIAVDRYLRVKIPVYKSVVTPRRAAVAIACCWIVSFLVGLTPMFGWNNLNN-V-VIKCQFE-----TVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFNLIRTQK-VSNDPQKYYGKELKIAKSLALVLFLFALSWLPLHILNCITLFCPSCKTPHILTYIAIFLTHGNSAMNPIVYAFRIKKFRTAFLQIWNQYFCCKTNKSSS--VN---------- >P2YR_MELGA PELLAG-----------GWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTG----KTITCYDT-TADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSLTEYKQNGDTSL >GRE1_BALAM ----MEGPPLSPAPADNVTLNVSCGRPATLFDWADHRLISLLALAFLNLMVVAGNLLVVMAVFVHSKLRTVTNLFIVSLACADLLVGMLVLPFSATLEVLDVWLYGDVWCSVWLAVDVWMCTSSILNLCAISLDRYLAVSQPIYPSLMSTRRAKQLIAAVWVLSFVICFPPLVGWNDR-G-S--LTCELT--------NERGYVIYSALGSFFLPSTVMLFFYGRIYRTAVSTRVSVRHQARRFRMETKAAKTVGIIVGLFILCWLPFFVCYLVRGFCADC-VPPLLFSVFFWLGYCNSAVNPCVYALCSRDFRFAFSSILCKCVCRRGAMERRFRRSQTEEDCEVAD >TDA8_MOUSE ---------------------MAMNSMCIEEQRHLEHYLFPVVYIIVFIVSVPANIGSLCVSFLQAKKENELGIYLFSLSLSDLLYALTLPLWINYTWNKDNWTFSPTLCKGSVFFTYMNFYSSTAFLTCIALDRYLAVVYPLFSFLRTRRFAFITSLSIWILESFFNSMLLWKDETS-DKSNFTLCYDK---YPLEKWQINLNLFRTCMGYAIPLITIMICNHKVYRAV------RHNQATENSEKRRIIKLLASITLTFVLCFTPFHVMVLIRCVLERDWQTFTVYRVTVALTSLNCVADPILYCFVTETGRADMWNILKLCTRKHNRHQGKKRRDAVELEIID-- >MSHR_CEREL PVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVAIPDGLFLSLGLVSLVENVLVVAAIAKNRNLQSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >NY1R_MOUSE TLFSKVENHSIHYNASE-NSPLLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDKD--KYVCFDK---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMIRDSKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >GPR1_MACMU EDLEETLFEEFENYSYALDYYSLESDLEEKVQLGVVHWVSLVLYCLSFVLGIPGNAIVIWFTGFKWKKTVS-TLWFLNLAIADFIFLLFLPLYISYVVMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVSHRHRTLKNSLIVIIFIWLLASLIGGPALYFR--D--NN-HTLCYNNHDPDLTVIRHHVLTWVKFIVGYLFPLLTMSICYLCLIFKV---------KKRSILISSRHFWTILAVVVAFVVCWTPYHLFSIWELTIHHNHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGNSETKNLCLLET >ACM1_PIG ------------MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFIVTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >RTA_RAT EAHSTNQNKMCPGMSEALELYSRGFLTIEQIATLPPPAVTNYIFLLLCLCGLVGNGLVLWFFGFSIK-RTPFSIYFLHLASADGIYLFSKAVIALLNMGTFLGSFPDYVRRVSRIVGLCTFFAGVSLLPAISIERCVSVIFPMYWRRRPKRLSAGVCALLWLLSFLVTSIHNYFCM-FL---SGTACL-----------NMDISLGILLFFLFCPLMVLPCLALILHVE---------CRARRRQRSAKLNHVVLAIVSVFLVSSIYLGIDWFLFWVFQ--IPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAEPGNTVTMEMQCPSG >GP43_HUMAN ------------------------------MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNT--N--ITCYEN-FTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQP------LVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQR---KSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRG---------TAE >CKR1_HUMAN METPNTTEDYDTTTEFDYGDATPC---QKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDD-WVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIIIWALAILASMPGLYFSKTQW-EF-HHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKIL---------LRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLV-------SSTS >VK02_SPVKA YEYSTITDYYNTINNDITSSSVIKAFDNNCTFLEDTKYHIIVIHIILFLLGSIGNIFVVSLIAFKRN-KSITDIYILNLSMSDCIFVFQIPFIVYSKLDQ--WIFGNILCKIMSVLYYVGFFSNMFIITLMSIDRYFAIVHPIRQPYRTKRIGILMCCSAWLLSLILSSPVSKLYENIP--MDIYQCTLTENDSIIAFIKRLMQIEITILGFLIPIIIFVYCYYRIFTTV---------VRLRNRRKYKSIKIVLMIVVCSLICWIPLYIVLMIATIVSLYLNLAYAITFSETISLARCCINPIIYTLIGEHVRSRISSICSCIYRDNRIRKKLFSNII--------- >AA1R_CAVPO ----------------------------MPHSVSAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIASLAVADVAVGALVIPLAILINIG--PQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKTVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLSN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCHKPTILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPEPPID--VDD--------- >P2Y6_RAT -----------MERDNGTIQAPGLPPTTCVYREDFKRLLLPPVYSVVLVVGLPLNVCVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLWHKRGGRRAAWVVCGVVWLVVTAQCLPTAVFAATG-----RTVCYDL-SPPILSTRYLPYGMALTVIGFLLPFTALLACYCRMARRLCRQ---GPAGPVAQERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRSTETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQKLTAKWQRQRV--------------- >O2H3_HUMAN ---------------MDNQSSTPGFLLLGFSEHPGLGRTLFVDVITSYLLTLVGNTLIILLSALDTKLHSPMYFFLSNLSFLDLCFTTSCVPQMLANLWGPKKTISFLDCSVQIFIFLSLGTTECILMKVMAFDRYVAVCQPLYATIIHPRLCWQLASVAWVIGLVGSVVQTPSTLHL---PDDFVCEVPRLSCEDTSYNEIQVAVASVFILVVPLSLILVSYGAITWAV--------LRINSATAWRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPY---AQGRGKFFGLFYAVGTPSLNPLVYTLRNKEIKRALRRLLGKERDSRESWRAA-------------- >OPRK_MOUSE LPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVDVD-VIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVASMRDVGGMNKP >5HTB_DROME TTSNLSQIVWNRSVNGNGNSNDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNI-YNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDE-E--QHCMVS--------QDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRPHQKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARARSAKI------------- >OPR._HUMAN GSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEE---IECLVE-IPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVALACKTSETVPR >VG74_KSHV LDDDESWNETLNMSGYDYSGNFSLEVSVCEMTTVVPYTWNVGILSLIFLINVLGNGLVTYIFCKHRS-RAGAIDILLLGICLNSLCLSISLLAEVLM--FLFNIISTGLCRLEIFFYYLYVYLDIFSVVCVSLVRYLLVAYSTSWPKKQSLGWVLTSAALLIALVLSGDACRHRSRVVD-PVKQAMCYEN---NMTADWRLHVRTVSVTAGFLLPLALLILFYALTWCVV---------RRTKLQARRKVRGVIVAVVLLFFVFCFPYHVLNLLDTLLRRRGLINVGLAVTSLLQALYSAVVPLIYSCLGSLFRQRMYGLFQSLRQSFMSGATT-------------- >PE22_MOUSE ---------------MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIALALLARRWRSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQLAPESHACTYFAFTMTFFSLATMLMLFAMALERYLSIGYPYYRRHLSRRGGLAVLPVIYGASLLFCSLPLLNYGEYVQYCPGTWCFIR--------HGRTAYLQLYATMLLLLIVAVLACNISVILNLIRMRGPRRGERTSMAEETDHLILLAIMTITFAICSLPFTIFAYMDETSS---LKEKWDLRALRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRTSLRTQEAQQTSSKQTDLCGQL-- >A1AD_RABIT GSGEDNRSSAGEPGGAGGGGEVNGTAAVGGLVVSAQSVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWAVALVVSMGPLLGWKEP--VP--RFCGIT--------EEVGYAVFSSLCSFYLPMAVIVVMYCRVYVVARSTHTFLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRASAGGGPHPDCA >OPSD_CRIGR MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVICKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVILMVVFFLICWFPYAGVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGKNILGDDEASATASKTETSQVAPA >AA1R_CANFA ----------------------------MPPAISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PRTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKTVVTPRRAAVAIAGCWILSFVVGLTPLFGWNRLGN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRRQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCRKPSILMYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPTPPVD--PHD--------- >DCDR_.ENLA ---------MENFSIFNVTVNVWHADLDVGNSDLSLRALTGLLLSLLILSTLLGNTLVCLAVIKFRHRSKVTNFFVISLAVSDLFVALLVMPWKAVTEVAGFWVFG-DFCDTWVAFDIMCSTASILNLCIISLDRYWAIASPFYERKMTQRVAFIMIGVAWTLSILISFIPVQLSWHKSEE-HTENCDSS--------LNRTYAISSSLISFYIPVVIMIGTYTRIYRIAQTQSSRENSLKTSFRKETKVLKTLSIIMGVFVFCWLPFFVLNCMIPFCHMNCVSETTFNIFVWFGWANSSLNPVIYAFNA-DFRKAFTTILGCNRFCSSNNVEAVNYHHDTTFQK--- >O.YR_BOVIN GAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLSRRTDRLAVLVTWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNRAIVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFVQMWSVWDADA-KEASPFIIAMLLASLNSCCNPWIYMLFTGHLFQELVQRFLCCSFRRLKGSRPGENSSTFVLSQYSS >YQNJ_CAEEL RDSVINASSAVSTTTLPPLDIPMTSMKPPSIIPTVELVLGTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVVTFLAGQWLLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPIYAQKRTTKFVCIVIVIVWILSMLISVPPIIGWNNW-M---EDSCGLS--------TEKAFVVFSAAGSFFLPLLVMVVVYVKIFISARQRNPTRKREKISVAKEKRAAKTIAVIIFVFSFCWLPFFVAYVIRPFCETCTLVQQVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKILCPKAVLEQRRRRMSA------------ >OPS2_PATYE ------------------MPFPLNRTDTALVISPSEFRIIGIFISICCIIGVLGNLLIIIVFAKRRSVRRPINFFVLNLAVSDLIVALLGYPMTAASAFSNRWIFDNIGCKIYAFLCFNSGVISIMTHAALSFCRYIIICQYGYRKKITQTTVLRTLFSIWSFAMFWTLSPLFGWSSYVIEVVPVSCSVN--WYGHGLGDVSYTISVIVAVYVFPLSIIVFSYGMILQEKVCGIRARYTPRFIQDIEQRVTFISFLMMAAFMVAWTPYAIMSALAIGSFN--VENSFAALPTLFAKASCAYNPFIYAFTNANFRDTVVEIMAPWTTRRVGVSTLPWRRRTSAVNTTDI >RGR_HUMAN ---------------------MAETSALPTGFGELEVLAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTRS---QLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLD--YSKGDRNFTSFLFTMSFFNFAMPLFITITSYSLME--------------QKLGKSGHLQVNTTLPARTLLLGWGPYAILYLYAVIADVTSISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK---------------- >PE23_PIG ------------MWAPERSAEEQGNLTRSLGSSEDCGSVSVVFPMTMLITGFVGNALAMLLVSQSYRRKKSFLLCIGWLALTDMVGQLLTSPVVIVLYLSHQLDPSGRLCTFFGLTMTAFGLSSLFIASAMAVERALAIRAPHYSSHMKTSATRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNETSSENNWGNIFFASAFSFLGLSALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKTIFNQTSQNECNFFLIAVRLASLNQILDPWVYLLLRKILLQKFCQAVSQKQREEAATLIFTHPGEARVLFSKSK >ACM1_MACMU ------------MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL--GQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >GPRF_CERAE ----MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYIAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPLKLIWSLVALIFTFFVPLLSIVTCYCRIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTSKLLAIVSGLQAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFT >NK3R_RAT -G--NFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATKIVIGSIWILAFLLAFPQCLYSK---GR---TLCYVQ--WPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGG--PCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSY----TTRFHPTRQSSL >CKR3_CERAE MTTSLYTVETFGPTSYDDDMGLLC---EKADVGALIAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVREHN-WVFSHGMCKVLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIVTWGLAVLVALPEFIFYGTEE-LF-ETLCSAIYPQDTVYSWRHFHTLKMTILCLALPLLVMAICYTGIIKTL---------LKCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILISTYQSILKHVDLVVLVTEVIAYSHCCVNPVIYAFVGERFRKYLRHFFHRHVLMHLGRYIPFLT-------SSVS >PE24_HUMAN --------------------MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFID---WTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMAAAASSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSEVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSQRTSSAMSGHSR >GPR4_PIG --------------------MGNGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLRLWAAYRQVRQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLFARLRRVKTAVAVSSVVWATELGANSVPLFHDEL--NH---TFCFEKPMEGWVAWMVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRG------SVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAVYLGERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLTSDKPQEMDTPLTSKRNSMA >PE23_BOVIN PFCTRFNHSDPGIWAAERAVEAPNNLTLPPEPSEDCGSVSVAFSMTMMITGFVGNALAITLVSKSYRRKKSFLLCIGWLALTDMVGQLLTSPVVIVLYLSHQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALATRAPHYSSHMKTSVTRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNGTNSRQNWGNVFFASAFAILGLSALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNHTSQDECNFFLIAVRLASLNQILDPWVYLLLRKILLQKFCQLLKGHSYGLDTEGGTENNLYISNLSRFFI >OPSD_RANCA MNGTEGPNFYVPMSNKTGIVRSPFEYPQYYLAEPWKYSVLAAYMFLLILLGLPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTITMYTSLHGYFVFGQTGCYFEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIISFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVVIMVIFFLICWVPYAYVAFYIFTHQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDEDASSAATSVSTSQVSPA >OPS6_DROME GR----NLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTD--YFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMKAVAAHNVANSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFESMH-LSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGKDDLTSDSRSESQA------- >OPRM_HUMAN LSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIPSTANTVDRTNH >AA2A_MOUSE ----------------------------------MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGMKAKGIIAICWVLSFAIGLTPMLGWNNCST-K-RVTCLFE-----DVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQESQGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGAHSTEGEQVSLR >OPSG_CAVPO DAYEDSTQASLFTYTNSNNTRGPFEGPNYHIAPRWVYHLTSAWMTIVVIASIFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIVFSWVWSAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCITPLSIIVLCYLHVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAYCLCWGPYAFFACFATANPGYSFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVEDSSELSSTSRSVSPAA------ >CCR4_CERTO IYTSDNYTEEMG-SGDYDSIKEPC---FREKNAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQKPRKLLAEKVVYVGVWIPALLLTIPGFIFASVSE-DD-RFICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >OPSB_ANOCA MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLGGQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSRYIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVREAAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTICCGKNPFGDEDVSSSVSSVSSSQVSPA >O1A2_HUMAN -------------MKKENQSFNLDFILLGVTSQQEQNNVFFVIFLCIYPITLTGNLLIILAICADIRLHNPMYFLLANLSLVDIIFSSVTIPKVLANHLLGSKFISFGGCLMQMYFMIALAKADSYTLAAMAYDRAVAISCPLYTTIMSPRSCILLIAGSWVIGNTSALPHTLLTASL---SANFYCDIMKLSCSDVVFFNVKMMYLGVGVFSLPLLCIIVSYVQVFSTV--------FQVPSTKSLFKAFCTCGSHLTVVFLYYGTTMGMYFRPLTSY----SPKDAVITVMYVAVTPALNPFIYSLRNWDMKAALQKLFSKRISS--------------------- >A2AC_MOUSE AEGPNGSDAGEWGSGGGANASGTDWVPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ----------------- >5H2C_RAT LLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD-VF--NTTCVL---------NDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQKKKPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKAKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIALSGRELNVNIY >OPRM_PIG FSHLEGNLSDPCIRNRTELGGSDSLCPPTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYGS---IDCALT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIPSTANTVDRTNH >B1AR_FELCA LPDGAATAARLLVPASPSASPLTPTSEGPAPLSQQWTAGIGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVMRGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCFARRAARGGHAAAGCLPGTRPPPSPG >BONZ_HUMAN ------MAEHDYHEDYGFSSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIYTINFYTSMLILTCITVDRFIVVVKATNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >CH23_HUMAN EDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN-SS--WPTHSQ-MDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------QRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK-FKVALFSRLVNALSEDTGHSFTKMSSMNERTS >TSHR_HUMAN LQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIVFVLTLNIVAFVIVCCCHVKIYITVRNP------QYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGSTDIQVQKVTHD >GHSR_PIG SEEPGPNLTLPDLGWDAPPENDSLVEELLPLFPTPLLAGVTATCVALFVVGIAGNLLTMLVVSRFREMRTTTNLYLSSMAFSDLLIFLCMPLDLFRLWQYRPWNLGNLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVG---T-D-TNECRAT---FAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRGE-AVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSLEPQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFEPFSQRKLSTLKDESSINT------ >B1AR_RAT LPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACRRRAAHGCLARAGPPPSPG >ACM2_CHICK -----------MNNSTYINSSSENVIALESPYKTIEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGIFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VP-DKDCYIQ------FFSNPAVTFGTAIAAFYLPVIIMTVLYWQISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWTPYNVMVLINSFCASC-IPGTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >GPRK_HUMAN ATAVTTVRTNASGLEVPLFHLFARLDEELHGTFPGLCVALMAVHGAIFLAGLVLNGLALYVFCCRTRAKTPSVIYTINLVVTDLLVGLSLPTRFAVYYGA---RGCLRCAFPHVLGYFLNMHCSILFLTCICVDRYLAIVRPEPAACRQPACARAVCAFVWLAAGAVTLSVLGVTG----------S-----------RPCCRVFALTVLEFLLPLLVISVFTGRIMCALSRP----GLLHQGRQRRVRAMQLLLTVLIIFLVCFTPFHARQVAVALWPDMHTSLVVYHVAVTLSSLNSCMDPIVYCFVTSGFQATVRGLFGQHGEREPSSGDVVSSGRHHILSAGPH >ACM1_HUMAN ------------MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >ML1A_HUMAN -------MQGNGSALPNASQ---PVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGT-LQYDP-IYSCTFA------QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVQR-PDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNWKPSPLMTNNNV >TSHR_RAT LQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSPMALLGNVFVLFVLLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHTWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSY----KVSICLPM-----TDTPLALAYIALVLLLNVVAFVIVCSCYVKIYITVRNP------QYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSGVLLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQANTGIQIQKIPQD >OPS2_DROME AQSS-GNGSVLDNVLPDMAHLVNPYWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSID--YMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHMNVRSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDG-LTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKEKCPMCVFGNTDEPKPDATSEADSKA---- >OPRD_HUMAN PPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPGA---VVCMLQ-FPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL-SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRARVTACTPSDGPG >OPSD_.ENLA MNGTEGPNFYVPMSNKTGVVRSPFDYPQYYLAEPWQYSALAAYMFLLILLGLPINFMTLFVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGPTGCYIEGFFATLGGEVALWSLVVLAVERYIVVCKPMANFRFGENHAIMGVAFTWIMALSCAAPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFTIPLIVIFFCYGRLLCTVKEAAAQQQESLTTQKAEKEVTRMVVIMVVFFLICWVPYAYVAFYIFTHQGSNFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQFRNCLITTLCCGKNPFGDEDGSSAASSVSSSQVSPA >PAFR_HUMAN ----------------------MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPITAQANTRKRGISLSLVIWVAIVGAASYFLILDSTN-G--NVTRCFEH---YEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQP---VQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDPFNQIPGNSLKN >OPSG_SCICA DSHEDSTQSSIFTYTNSNATRGPFEGPNYHIAPRWVYHITSTWMIIVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLAETVIASTISVVNQLYGYFVLGHPLCVVEGYTVSVCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIIPLSIIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATANPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDTSELSSASKSVSPAA------ >HH2R_RAT -------------------MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWN--RN-TF-KCKVQ--------VNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQR--ISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDD-INEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRRSQSREGRW--- >V1AR_RAT SSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITSSFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIETK--TQDCWAT---FIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNLLVVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSTSYSNNRSPTNS >GPR1_HUMAN EDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGLKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVSHRHRTLKNSLIVIIFIWLLASLIGGPALYFR--D--NN-HTLCYNNHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKV---------KKRTVLISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGNSETKNLCLLET >DADR_MACMU --------------MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-TIDNCDSS--------LSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGCIDSITFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPATNNAIETAAMFSSH----- >AG2R_CANFA ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYVAIVHPMSPVRRTMLMAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKTLKRA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------H >OPSD_ATHBO MNGTEGPYFYIPMLNTTGVVRSPYEYPQYYLVNPAAYAVLGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNVEGFSATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMAAACAVPPLFGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFTCHFCIPLMVVFFCYGRLVCAVKEAAAAQQESETTQRAEREVTRMVIIMVVSFLVSWVPYASVAWYIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASSSSVSSSSVSPAA >RDC1_RAT YVEPGNYSDSNWPCNSSDCIVVDTVQCPAMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTTSSYKKKMVLRVVCVLVWLLAFFVSLPDTYYLKTVTNNE--TYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAM---------SASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHNVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNAKA- >IL8A_RAT EGDFEEEFGNITRMLPTGEYFSPC----KR-VPMTNRQAVVVFYALVFLLSLLGNSLVMLVILYRRRTRSVTDVYVLNLAIADLLFSLTLPFLAVSKWKG--WIFGTPLCKMVSLLKEVNFFSGILLLACISVDRYLAIVHATRTLTRKRYLVKFVCMGTWGLSLVLSLPFAIFRQAYK-RS-GTVCYEV-LGEATADLRITLRGLSHIFGFLLPLFIMLVCYGLTLRTL---------FKAHMRQKRRAMWVIFAVVLVFLLCCLPYNLVLLSDTLLGAHNNIDQALYITEILGFSHSCLNPVIYAFVGQSFRHEFLKILAN--LVHKEVLTHHS------------ >CB2R_RAT ----MEGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHG-VDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPYKALVTRGRALVALGVMWVLSALISYLPLMGWTC-----CPSPCSEL------FPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHTEHQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKVTETEAEVKTTT >LSHR_HUMAN ESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCSTAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----KVSICFPM-----VETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNP------ELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRSNCKNGFTGSNK >OPSD_LIZSA MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAIERWMVVCKPISNFRFGEDHAIMGLAFTWVMAAACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLICWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >CB1R_FELCA EFYNKSLSSYKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKKIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCK-K--LQSVCSDI------FPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHIHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGHANNTANVHRAA >EDG3_HUMAN TALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAG-IAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCL-H--NLPDCSTI------LPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSS---KVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQCPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIRSKSSSSNNSSH >UR2R_HUMAN AATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKE-WHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMR---GP--KSLCLPA----WGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQR--ASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLRCSGRSLSSCSP >AA2B_CHICK --------------------------------MNTMKTTYIVLELIIAVLSIAGNVLVCWAVAINSTLKNATNYFLVSLAVADIAVGLLAIPFAITISIG--FQVDFHSCLFFACFVLVLTQSSIFSLLAVAIDRYLAIKIPLYNSLVTGKRARGLIAVLWLLSFVIGLTPLMGWNKAMG-A-FISCLFE-----NVVTMSYMVYFNFFGCVLLPLIIMLGIYIKIFMVACKQ---MGNSRTTLQKEVHAAKSLAIIVGLFAFCWLPLHILNCITHFHEEFSKPEWVMYVAIILSHANSVINPIIYAYRIRDFRYTFHKIISKILCKTDDFPKCTTVTNVNAPAASVT >5H2A_MOUSE NTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESNVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILAYKSSQLQVGQK >US27_HCMVA -------MTTSTNNQTLTQVSNMTNHTLNSTEIYQLFEYTRLGVWLMCIVGTFLNVLVITTILYYRRKKSPSDTYICNLAVADLLIVVGLPFFLEYAKHHP-KLSREVVCSGLNACFYICLFAGVCFLINLSMDRYCVIVWGVLNRVRNNKRATCWVVIFWILAVLMGMPHYLMYSHT-----NNECVGE-ANETSGWFPVFLNTKVNICGYLAPIALMAYTYNRMVRFI---------INYVGKWHMQTLHVLLVVVVSFASFWFPFNLALFLESIRLLANVIIFCLYVGQFLAYVRACLNPGIYILVGTQMRKDMWTTLRVFACCCVKQEIPYQKDIQRRAKHTKR >NK1R_HUMAN -----MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVICVIWVLALLLAFPQGYYST---SR---VVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLE---IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY----STRYLQTQGSVY >5H1A_HUMAN -MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAALISLTWLIGFLISIPPMLGW-----DP--DACTIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRKNEEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ-------------------- >IL8B_MOUSE SGDLDIFN-YSSGMPSILPDAVPC----HSENLEINSYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNG--WTFGSTLCKIFSYVKEVTFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCIAMWLLSVILALPILILRNPVK-LS-TLVCYED-VGNNTSRLRVVLRILPQTFGFLVPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVLFTDTLMRTKDDIDKALNATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMATYGLVSKEFLAKEG------------ >GPRY_MOUSE LCSSHGMHFITNYSDQASQNFGVPNVTSCPMDEKLLSTVLTTFYSVIFLVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQRRAITTKQSIYVCCIVWTVALAGFLTMIILTLKK-----STMCFHY--RDRHNAKGEAIFNFVLVVMFWLIFLLIILSYIKIGKNLLRISKR--SKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNEIIHKTNEIMLVFSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQSEASRSESTSLHDLSVTVKMPQ >PAR2_RAT ---LDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIY--N--TTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTL------SAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLKSSS-------- >5H5A_MOUSE LPVNLTSFSLSTPSSLEPNRSDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGE-S-E-SEECQVS--------REPSYTVFSTVGAFYLPLWLVLFVYWKIYRAAKFRATVTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW-DVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ----------------------- >IL8A_GORGO PQMWDFDDLNFTGMPPIDEDYSPC----RLETETLNKYVVIITYALAFLLSLLGNSLVMLVILYSRGGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMILSLPFFLFRQAYH-NS-SPVCYEV-LGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNNVSLALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHR------------ >5H2A_RAT NTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESNVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILAYKSSQLQVGQK >SSR2_BOVIN ELNETQPWLTTPFDLNGSVGAANISNQTEPYYDLASNVVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDLNETTETQRTLL >GP42_HUMAN -----------------------MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD--T--GTCYLE-FWKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGR--------GGSHRRQRRVAGLVAATLLNFLVCFGPYNVSHVVGYICG---ESPVWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSGGEEQRADRPAE >APJ_MACMU ---------MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSRKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVNARLRLRVSGAVATAVLWVLAALLAMPVMVFRTTGDQCY-MDYSMVA-TVSSDWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFR--KERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLLFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSSSGHSQGPGPNM >AG22_MOUSE RNITSSRPFDNLNATGTNESAFNC----SHKPSDKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLALADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRT-LG--NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSREMD-------T >FSHR_SHEEP FDMMYSEFDYDLCSEVVDVTCSPEPDAFNPCEDIMGYDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVHVRHAASIMLVGWVFAFAVALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTRNFRRDFFILLSKFGCYEVQAQTYRSNFHPRNGHCPPA >YN84_CAEEL EVFHHISTTNKIFQKMFDKRNFSTDYTFNPKTFPGYRTYVASTYISFNVVGFVINAWVLYVVAPLLFVPKSILFYIFALCVGDLMTMIAMLLLVIELVFG--TWQFS-SMVCTSYLIFDSMNKFMAPMIVFLISRTCYSTVCLGEKAATLKYAIIQFCIAFAFVMILLWPVFAYSQVFTQEVVMRKCGFF----PPPQIEFWFNLIACITSYAVPLFGIIYWYVSVPFFLKRR---LVASSSMDAALRKVITTVLLLTVIYVLCWTPYWVSMFANRIWIMEKSIIIISYFIHLLPYISCVAYPLIFTLLNRGIRSAHAKIVADQRRRFRSLTDEASRTIPGTKMKKNE >5H1D_CANFA SPPNQSLEGLLQEASNRSLNATETPEAWGPETLQALKISLALLLSIITMATALSNAFVLTTIFLTRKLHTPANYLIGSLAMTDLLVSILVMPISIAYTTTRTWSFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGRAAVMIATVWVISICISIPPLFWR----Q-E--SDCQVN-------TSQISYTIYSTCGAFYIPSVLLIILYGRIYVAARNRKLALERKRISAARERKATKTLGIILGAFIVCWLPFFVASLVLPICRASWLHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQRVVHVRKAS--------------------- >GASR_BOVIN GASLCRSGGPLLNGSGTGNLSCEPPRIRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVVCKAVSYFMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVIVATWMLSGLLMVPYPVYTAVQP---V-LQCMHR---WPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGPGPTRPAQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGALSGAPISFIHLLTYASACVNPLVYCFMHRRFRQACLDTCTRCCPRPPRARPRPLPSIASLSRLSYT >BRS4_BOMOR QTLPSAISSIAHLESLNDSFILGAKQSEDVSPGLEILALISVTYAVIISVGILGNTILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDASRYIVDTWMFGRAGCKIISFIQLTSVGVSVFTLTVLSADRYRAIVKPLLQTSDAVLKTCGKAVCVWIISMLLAAPEAVFSDLYETT--FEACAPY---VSEKILQETHSLICFLVFYIVPLSIISAYYFLIAKTLYKSMPAHTHARKQIESRKRVAKTVLVLVALFAVCWLPNHMLYLYRSFTYHSAFHLSATIFARVLAFSNSCVNPFALYWLSRSFRQHFKKQVYCCKTEPPAS--QQSTGITAVKGNIQM >OPSB_RAT -----MSGE-EFYLFQNISSVGPWDGPQYHIAPVWAFHLQAAFMGFVFFAGTPLNATVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYLVICKPFGNIRFNSKHALTVVLITWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEHYTWFLFIFCFIIPLSLICFSYFQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLYLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMTD---ESDMSSTVSSSKVGPH- >NK2R_RABIT ----MGACDIVTEANISSDIDSNATGVTAFSMPGWQLALWATAYLALVLVAVVGNATVIWIILAHRRMRTVTNYFIVNLALADLCMATFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSGPGTKAVIAGIWLVALALAFPQCFYST---GA---TKCVVAWPEDSGGKMLLLYHLTVIALIYFLPLVVMFVAYSVIGFKLWRRPGHHGANLRHLRAKKKFVKTMVLVVVTFAVCWLPYHLYFLLGHFQDDIKFIQQVYLVLFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----HTPSLSVRVNRC >PAR2_MOUSE ---LETQPPITGKGVPVEPGFSIDEFSASILTGKLTTVFLPVVYIIVFVIGLPSNGMALWIFLFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNNWVYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHPRKKANIAVGVSLAIWLLIFLVTIPLYVMKQTIY--N--TTCHDVLPEEVLVGDMFNYFLSLAIGVFLFPALLTASAYVLMIKTL------SAMDEHSEKKRQRAIRLIITVLAMYFICFAPSNLLLVVHYFLIKTSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDHARNALLCRSVRTVNRMQISLKSGS-------- >OPSD_CARAU MNGTEGDMFYVPMSNATGIVRSPYDYPQYYLVAPWAYACLAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAISDLFMVFGGFTTTMYTSLHGYFVFGRVGCNPEGFFATLGGEMGLWSLVVLAFERWMVVCKPVSNFRFGENHAIMGVVFTWFMACTCAVPPLVGWSRYIPEGMQCSCGVDYYTRPQAYNNESFVIYMFIVHFIIPLIVIFFCYGRLVCTVKEAAAQHEESETTQRAEREVTRMVVIMVIGFLICWIPYASVAWYIFTHQGSEFGPVFMTLPAFFAKTAAVYNPCIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >TRFR_HUMAN ------------MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNLNVNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVKESDHFSTELDD >PE24_MOUSE GTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFID---WTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMAAAVASFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSRRTSSAMSGHSR >C3AR_CAVPO --------------MESSSAETNSTGLHLEPQYQPETILAMAILGLTFVLGLPGNGLVLWVAGLKMR-RTVNTVWFLHLTVADFVCCLSLPFSMAHLALRGYWPYGEILCKFIPTVIIFNMFASVFLLTAISLDRCLMVLKPICQNHRNVRTACIICGCIWLVAFVLCIPVFVYRETFT-EE-DDLSPFT-HEYRTPRLLKVITFTRLVVGFLLPMIIMVACYTLIIFRM--------RRVRVVKSWNKALHLAMVVVTIFLICWAPYHVFGVLILFINPEAALLSWDHVSIALASANSCFNPFLYALLGRDLRKRVRQSMKGILEAAFSEDISKSAFS--------- >GPR3_MOUSE GAGSSMAWFSAGSGSVNVSSVDPVEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAG-LGLVLHFAAD-F--CIGSPEMSLMLVGVLAMAFTASIGSLLAITVDRYLSLYNALYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCR-D--GLTTCGVV-------YPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHIALHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDA----DSPRLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSP------------ >OPSD_OCTDO --MVESTTLVNQTWWYNPTVDIHPHWAKFDPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDLSFSAINGFPLKTISAFMKWIFGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMASKKMSHRRAFLMIIFVWMWSIVWSVGPVFNWGAYVPEGILTSCSFD--YLSTDPSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHRLNLRKAQAGASAEMKLAKISMVIITQFMLSWSPYAIIALLAQFGPAEWVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWLLTCCQFDEKECEEVVASERG-GES >B1AR_MELGA WLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDL-K--GCCDFV--------TNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQNGRRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDL-VPDWLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFKRLLCFPRKADRRLHAGGQFISTLGSPEHSP >5H1B_CAVPO PAVLGSQTGLPHANVSAPPNNAP-SHIYQDSIALPWKVLLVVLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAFTDLLVSILVMPISTMYTVTGRWTLGQALCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPRRAAGMIALVWVFSICISLPPFFWR----E-E--LDCLVN-------TDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGVILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTT--------------------- >BRB2_MOUSE IEMFNVTTQVLGSALNGTLSKDNC---PDTEWWSWLNAIQAPFLWVLFLLAALENLFVLSVFFLHKNSCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMRE-HN--TACVIV---YPSRSWEVFTNVLLNLVGFLLPLSVITFCTVRILQVLRNN---EMKKFKEVQTERKATVLVLAVLGLFVLCWVPFQISTFLDTLLRLGHAVDVITQISSYVAYSNSGLNPLVYVIVGKRFRKKSREVYRVLCQKGGCMGEPVQLRTS-------I >OPSB_APIME YVPSMREKFLGWNVPPEYSDLVRPHWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFSTSKSLRTPSNMFIVSLAIFDIIMAFEMPMLVISSFMERM--GWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYRTISCPI-DGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTEGFLTTCSFD--FLTDDEDTKVFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHNVKSNQDKER-SAEVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNRELLTPVSTMLPAVFAKTVSCIDPWIYAINHPRYRQELQKRCKWMGIHEPETTSDATKTDE-------- >O.YR_HUMAN GALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNRVAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANA-KEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGENSSSFVLSHRSS >OPSR_CAPHI ANFEESTQGSIFTYTNSNSTRDPFEGPNYHIAPRWVYHLTSAWMVFVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAIADLAETIIASTISVVNQMYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLATAGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMITCCFIPLSVIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVMVMIFAYCLCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDS-----SELASSV--SSVSPA >APJ_HUMAN ---------MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSRKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVNARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDQCY-MDYSMVA-TVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFR--KERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSSSGHSQGPGPNM >NY1R_PIG TLSSQVENHSIYYNFSEKNSQFLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEVMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPSNRHAYVGIAVIWVLAVASSLPFLIYQVLTDKD--KYVCFDK---FLSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMMRDNKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCINPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >OAR1_LYMST ---------MSRDIFMKRLRLHLLFDEVAMVTHIVGDVLSSVLLCAVVLLVLVGNTLVVAAVATSRKLRTVTNVFIVNLACADLLLGVLVLPFSAVNEIKDVWIFGHVWCQVWLAVDVWLCTASILNLCCISLDRYLAITRPIYPGLMSAKRAKTLVAGVWLFSFVICCPPLIGWNDGGT-Y--TTCELT--------NSRGYRIYAALGSFFIPMLVMVFFYLQIYRAAVKTHKPMRLHMQKFNREKKAAKTLAIIVGAFIMCWMPFFTIYLVGAFCENC-ISPIVFSVAFWLGYCNSAMNPCVYALFSRDFRFAFRKLLTCSCKAWSKNRSFRPIQLHCATQDDAK >OLF5_CHICK -------------MALGNCTTPTTFILSGLTDNPRLQMPLFMVFLAIYTITLLANLGLIALISVDFHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERRTISYVGCILQYFSFVLLTSSECLLLAVMAYDRYVAICKPLYPAIMTKAVCWRLVEGLYSLAFLNSLVHTSGLLKL---SNHFFCDNSQISSSSTTLNELLVFIFGSWFAMSSIITTPISYVFIILTV--------VRIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRVIATNVWIH-------------------- >A2AR_CARAU ----------MDVTQSNATKDDANITVTPWPYTETAAAFIILVVSVIILVSIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLANEIMGYWFFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVYNLKRTPKRIKSMIAVVWVISAVISFPPLIMTKH-------KECLIN--------DETWYILSSSLVSFFAPGFIMITVYCKIYRVAKQRSKQASKTKVAQMREKRFTFVLTVVMGVFVLCWFPFFFTYSLHAICGDSEPPEALFKLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKICLLDCAAHLRDSCLGTCIFECHQKSNQE >VQ3L_CAPVK SNYTTAYNTTYYSDDYDDYEVSIVDIPHCDDGVDTTSFGLITLYSTIFFLGLFGNIIVLTVLRKYKI-KTIQDMFLLNLTLSDLIFVLVFPFNLYDSIAKQ-WSLGDCLCKFKAMFYFVGFYNSMSFITLMSIDRYLAVVHPVSMPIRTKRYGIVLSMVVWIVSTIESFPIMLFYETKK-VY-ITYCHVF-YNDNAKIWKLFINFEINIFGMIIPLTILLYCYYKILNTL----------KTSQTKNKKAIKMVFLIVICSVLFLLPFSVTVFVSSLYLLNRFVNLAVHVAEIVSLCHCFINPLIYAFCSREFTKKLLRLRTTSSAGSISIG---------------- >GP40_HUMAN --------------------------------MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGTPVGSPVCLEA----WDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRAL-------ARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYP--NLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK------------------ >CKR8_MACMU --MDYTLDPSMTTMTDYYYPDSLSSPCDGELIQRNDKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRNITDIYLLNLALSDLLFVFSFPFQTYYQLDQ--WVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVIKVRTIRMGTTTLSLLVWLTAIMATIPLLVFYQVAS-ED-VLQCYSF-YNQQTLKWKIFTNFEMNILGLLIPFTIFMFCYIKILHQL---------KRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHQQLNYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSHIFIYLGRQMSSSCQQHSFRSS >NTR1_RAT EATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQN--SGGLVCTPI---VDTATVKVVIQVN-TFMSFLFPMLVISILNTVIANKLTVMEHSMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPSMSSNHAFSTSA >B3AR_MACMU MAPWPHGNSSLVPWPDVPTLAPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIVAITRTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLVLTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRVQ-R--RCCAFA--------SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPS-VPDPAFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCHCGGRLPREPCAADAPLRPGPAPRSP >GALS_MOUSE ------------MNGSDSQGAEDSSQE-GGGGWQPEAVLVPLFFALIFLVGAVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPMSRELRTPRNALAAIGLIWGLALLFSGPYLSYYS---AN--LTVCHPA----WSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLHYLWRTDP-VAAGSGSQRAKRKVTRMIVIVAVLFCLCWMPHHALILCVWFGRFPRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRRAPRRASGRVHSGGMLEPESTD >P2Y3_MELGA ----------------MSMANFTAGRNSCTFQEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTG-----RTVCYDL-SPPDRSASYFPYGITLTITGFLLPFAAILACYCSMARILCQK---ELIGLAVHKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRHDHCITY------------ >OPSD_TURTR MNGTEGLNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVANLFMVFGGFTTTLYTSLHAYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWIMAMACAAAPLVGWSRYIPEGMQCSCGIDYYTSRQEVNNESFVIYMFVVHFTIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFTHQGSDFGPIFMTIPSFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGRNPLGDDEASTTASKTETSQVAPA >A2AB_CAVPO -------------------------MDHQEPYSVQATAAIAAVITFLILFTIFGNALVILAVLTSRSLPAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCKIN--------QEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSGAVWWRRRTQMTREKRFTFVLAVVIGVFVLCWFPFFFTYSLGAICPQHKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTAW------------------ >CML1_MOUSE EYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVIYSLVCFLGLLGNGLVIVIATFKMK-KTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYHWVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVSQNHRSIRLAYMTCSAVWVLAFFLSSPSLVFRDTAN-SS--HPAHSQ-VVSTGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKL---------QRNRLAKNKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRK-FKVALFSRLANALSEDTGPSFTKMSSLNEKAS >5HT1_APLCA -MKSLKSSTHDVPHPEHVVWAPPAYDEQHHLFFSHGTVLIGIVGSLIITVAVVGNVLVCLAIFTEPISHSKSNFFIVSLAVADLLLALLVMTFALVNDMYGYWLFGETFCFIWMSADVMCETASIFSICVISYDRLKQVQKPLYEEFMTTTRALLIIACLWICSFVLSFVPIFLEWHELGD-AKHVCLFD--------VHFTYSVIYSFICFYVPCTLMLTNYLRLFLIAQTHQLRASSYRNQGTQGSKAARTLTIITGTFLACWLPFFIINPIAAADEHL-IPLECFMVTIWLGYFNSSVNPIIYGTSNSKFRAAFKRLLRCRSVKSVVGSISPVSWIRPSRLDLSS >5H1A_FUGRU NDSNATSGYSDTAAVDWDEGENATGSGSLPDPELSYQIITSLFLGALILCSIFGNSCVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQDICDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAVLISVTWLIGFSISIPPMLGWRS---NP--DACIIS--------QDPGYTIYSTFGAFYIPLILMLVLYGRIFKAARFRINEGTRRKIALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCAENYMPEWLGAVINWLGYSNSLLNPIIYAYFNKDFQSAFKKILRCKFHRH-------------------- >ACTR_BOVIN -------------MKHILNLYENINSTARNNSDCPAVILPEEIFFTVSIVGVLENLMVLLAVAKNKSLQSPMYFFICSLAISDMLGSLYKILENVLIMFKNMGSFESTADDVVDSLFILSLLGSICSLSVIAADRYITIFHALYHRIMTPHRALVILTVLWAGCTGSGITIVTFFS----------------------HHHVPTVIAFTALFPLMLAFILCLYVHMFLLARSH---TRRTPSLPKANMRGAVTLTVLLGVFIFCWAPFVLHVLLMTFCPADACYMSLFQVNGVLIMCNAIIDPFIYAFRSPELRVAFKKMVICNCYQ--------------------- >CKR9_MOUSE DDFSYDSTASTDDYMNLNFSSFFC---KKNNVRQFASHFLPPLYWLVFIVGTLGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLATLPFWAIAAAGQ--WMFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIVQAMVWRQKRLLYSKMVCITIWVMAAVLCTPEILYSQVSG-G--IATCTMVYPKDKNAKLKSAVLILKVTLGFFLPFMVMAFCYTIIIHTL---------VQAKKSSKHKALKVTITVLTVFIMSQFPYNSILVVQAVDAYATNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFT--------GSLK >5H1B_SPAEH CAPPPPAGSQTQTPSSNLSHNSADSYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPRRAAVMIALVWVFSISISLPRFFWR----E-E--LDCLVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFNWLGYLNSLINPIIYTMPNEDFKQAFHKLIRFKCTG--------------------- >OPS4_DROVI VSGNGDLQFLGWNVPPDQIQHIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKALRTPSNMFVLNLAVFDFIMCLKAPIFIYNSFHRG-FALGNTGCQIFAAIGSYSGIGAGMTNAAIGYDRLNVITKPM-NRNMTFTKAIIMNVIIWLYCTPWVVLPLTQFWDRFPEGYLTSCTFD--YLTDNFDTRLFVGTIFFFSFVCPTLMIIYYYSQIVGHVFSHNVESNVDKSKDTAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRMELQKRCPWLAIDEKAPESSSAEQQQTTAA---- >OPSG_RABIT ESHEDSTQASIFTYTNSNSTRGPFEGPNFHIAPRWVYHLTSAWMILVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETVIASTISVVNQFYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIAGIAFSWIWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIIPLSVIVLCYLQVWMAIRTVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYSFHPLVAAIPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVEDS-----SELASSV--SSVSPA >NK3R_RABIT LVQAGNLSSSLPSSVPGLPTTPRANLTNQFVQPSWRIALWSLAYGVVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATKIVIGSIWILAFLLALPQCLYSK---GR---TLCYVQ--WPEGPKQHFIYHIIVIILVYCFPLLIMGITYTIVGITLWGG--PCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELEPTRQSSLYTVTR >ACM5_HUMAN -------MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLV-VP-LDECQIQ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRNPSTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYW------------ >O3A1_HUMAN ----------MQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVRGNLSILAAVLVEPKLHTPMYFFLGNLSVLDVGCISVTVPSMLSRLLSRKRAVPCGACLTQLFFFHLFVGVDCFLLTAMAYDQFLAICRPLYSTRMSQTVQRMLVAASWACAFTNALTHTVAMSTL---NNHFYCDLPQLSCSSTQLNELLLFAVGFIMAGTPMALIVISYIHVAAAV--------LRIRSVEGRKKAFSTCGSHLTVVAIFYGSGIFNYMRLGSTK---LSDKDKAVGIFNTVINPMLNPIIYSFRNPDVQSAIWRMLTGRRSLA-------------------- >CKRB_BOVIN YNQSTDYYYEENEMNDTHDYSQYEVICIKEEVRKFAKVFLPAFFTIAFIIGLAGNSTVVAIYAYYKKRRTKTDVYILNLAVADLFLLFTLPFWAVNAVHG--WVLGKIMCKVTSALYTVNFVSGMQFLACISTDRYWAVTKAP-SQSGVGKPCWVICFCVWVAAILLSIPQLVFYTVN----HKARCVPI--YHLGTSMKASIQILEICIGFIIPFLIMAVCYFITAKTL---------IKMPNIKKSQPLKVLFTVVIVFIVTQLPYNIVKFCQAIDIIYKRMDVAIQITESIALFHSCLNPVLYVFMGTSFKNYIMKVAKKYGSW---------NVEEIPFESEDA >TA2R_HUMAN --MWPNG-----------SSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLT----LGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRRVSLCGPAWSTATSASRVQAIL >AG2R_CHICK ------MVPNYSTEETVKRIHVDC---PVSGRHSYIYIMVPTVYSIIFIIGIFGNSLVVIVIYCYMKLKTVASIFLLNLALADLCFLITLPLWAAYTAMEYQWPFGNCLCKLASAGISFNLYASVFLLTCLSIDRYLAIVHPVSRIRRTMFVARVTCIVIWLLAGVASLPVIIHRNIFF-LN--TVCGFR-YDNNNTTLRVGLGLSKNLLGFLIPFLIILTSYTLIWKTLKKA----YQIQRNKTRNDDIFKMIVAIVFFFFFSWIPHQVFTFLDVLIQLHDIVDTAMPFTICIAYFNNCLNPFFYVFFGKNFKKYFLQLIKYIPPNVSTHPSLTTRPPE-------N >P2YR_MOUSE AAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTG----KTVTCYDT-TSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVKALIY------NDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLSEFKQNGDTSL >NY5R_RAT -------------NTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVESS--KYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGAHEKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS--------------------- >THRR_PAPHA LTEYRLVSINKSSPLQKPLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPVNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYLSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQ--N--TTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCL------SSSTVANRSKKSRALFLSAAVFCIFIICFGPTNILLIAHYSFLSHEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSSNSSGDTCS-------- >FSHR_HUMAN FDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNP------NIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTNTHPRNGHCSSA >OPSB_CONCO MNGTEGPNFYVPMSNATGVVRSPFEYPQYYLAEPWAFSILAAYMFFLIITGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGETGCNLEGYFATLGGEISLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLTLTWVMANACAMPPLFGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFLVHFTIPLTIISFCYGRLVCAVKEAAAQQQESETTQRAEREVTRMVVIMVISFLVCWIPYASVAWYIFTHQGSTFGPIFMTVPSFFAKSSSIYNPMIYICMNKQFRNCMITTLFCGKNPFEGEE--EGASAVSS--VSPA >A2AA_HUMAN ----MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGQ-P--PRCEIN--------DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRRVGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >OPSD_TRIMA MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTLPAFFAKSASIYNPVIYIMMNKQFRNCMLTTICCGKNPFAEEEGATTVSKTETSQVAPA >AA3R_HUMAN -------------------------MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLG--ITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWN-MKE-Y-FLSCQFV-----SVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNK--NSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTS------------ >ET1R_HUMAN ELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPKT--HKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPWKNHDQNNHNTD >GALS_HUMAN ------------MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR---AN--LTVCHPA----WSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRADP-VAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVHSGSVLERESSD >OPSV_ORYLA -------MGKYFYLYENISKVGPYDGPQYYLAPTWAFYLQAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVAGLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGV-VRCPPFFGWSRYIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRAVAAQQAESASTQKAEKEVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQFNGCIMEMVFGKKMEE-----ASESTDS-------- >YWO1_CAEEL ----------------------------MNHVDYVAHVIVMPIVLSIGMINQCLNVCTLLHIRT------SIFLYLKASAIADILSIVAFIPFLFRHAKLIDELGMFYHAHLELPLINALISASALNIVAMTVDRYVSVCHPINETKPSRRRTMLIIVMIYFIALMIYFPSVFQKKLG-VTTIYTIVRNE---VEALQVFKFYLIVRECICRWGPVLLLVILNMCVVRGLRKIRTEQRQLRSPRDDRSRISVLLFVTSATFIICNIPASVISFFVRRVSGSLFWQIFRAIANLLQVTSYLYNFYLYALCSSEYRHAFLRLFGCRSSLSPTSTGDSPGKRCHQAVVLLG >CKR5_RAT --MDFQGSIPTYIYDIDYSMSAPC---QKVNVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANE--WVFGNIMCKLFTGIYHIGYFGGIFFIILLTIDRYLAIVHAVAIKARTVNFGVITSVVTWVVAVFVSLPEIIFMRSQK-EG-HYTCSPHFLHIQYRFWKHFQTLKMVILSLILPLLVMVICYSGILNTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEYFNRLDQAMQVTETLGMTHCCLNPVIYAFVGEKFRNYLSVFFRKHIVKRFCKHCSIFV-------SSVY >5HT_HELVI TSSEWFDGSNCSWVDAVSWGCTSTNATSTDVTSFVLMAVTSVVLALIILATIVGNVFVIAAIIIERNLQNVANYLVASLAVADLMVACLVMPLGAVYEVSQGWILGPELCDMWTSSDVLCSSASILHLVAIATDRYWAVTDV-YIHIRNEKRIFTMIVLVWGAALVVSLAPQLGWKDPDT-Q--QKCLVS--------QDLAYQIFATMSTFYVPLAVILILYWKIFQTARRRPAPEKKESLEAKRERKAAKTLAIITGAFVFCWLPFFIMALVMPICQTCVISDYLASFFLWLGYFNSTLNPVIYTIFSPDFRQAFARILFGTHRRRRYKKF--------------- >NTR2_HUMAN -----METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARARAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKH--AASRVCTVL---VVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALGQVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPMDTASGFGDPPE >NY4R_MOUSE HFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFIITTYSIETILGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPT-GWKPSIFQAYLGIVVIWFISCFLSLPFLANSTLNDED--KVVCFVS---WSSDHHRLIYTTFLLLFQYCIPLAFILVCYIRIYQRLQRQKHVAHACSSRAGQMKRINSMLMTMVTAFAVLWLPLHVFNTLEDWYQEACHGNLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIKALVLTCHCRSPQGES---TVHTDLSKGSMR >PE21_RAT --MSPYG-LNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAG-RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFIS--LGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRDRRRSRGLRRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLSSLRSSRHSGFS >OPSG_RAT DHYEDSTQASIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSTWMILVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDS-----SELVSSV--SSVSPA >P2UR_MOUSE ----MAADLEPWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLSLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTS-----RITCHDT-SARELFSHFVAYSSVMLGLLFAVPFSVILVCYVLMARRLLKP---YGTTGGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARRKL--TVRKDLSVSS >A2AC_DIDMA -MDLQLTTNSTDSGDRGGSSNESLQRQPPSQYSPAEVAGLAAVVSFLIVFTIVGNVLVVIPVLTSRALKAPQNLFLVSLASADILVATLVMPFSLANELMNYWYFGKVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRIKGIIVTVWLISAVISFPPLISLYR-------PQCELN--------DETWYILSSCIGSFFAPCIIMVLVYVRIYRVAKLRRRKLCRRKVTQAREKRFTFVLAVVMGVFVVCWFPFFFTYSLYGICREAQVPETLFKFFFWFGYCNSSLNPVIYTIFNQDFRRSFKHILFKKKKKTSLQ----------------- >GPR1_RAT EVSREMLFEELDNYSYALEYYSQEPDAEENVYPGIVHWISLLLYALAFVLGIPGNAIVIWFMGFKWK-KTVTTLWFLNLAIADFIFVLFLPLYISYVALSFHWPFGRWLCKLNSFIAQLNMFSSVFFLTVISLDRYIHLIHPGSHPHRTLKNSLLVVLFVWLLASLLGGPTLYFR--D--NN-RIICYNNQEYELTLMRHHVLTWVKFLFGYLLPLLTMSSCYLCLIFKT---------KKQNILISSKHLWMILSVVIAFMVCWTPFHLFSIWELSIHHNNVLQGGIPLSTGLAFLNSCLNPILYVIISKKFQARFRASVAEVLKRSLWEASCSGSAETKSLSLLET >CCR4_PAPAN IYTSDNYTEEMG-SGDYDSIKEPC---FREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >D2D1_.ENLA ---MDPQNLSMYNDD------INNGTNGTAVDQKPHYNYYAMLLTLLVFVIVFGNVLVCIAVSREKALQTTTNYLIVSLAVADLLVATLVMPWAVYMEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLN---S----KVCII---------DNPAFVIYSSIVSFYVPFIVTLLVYVQIYIVLRKRRTSMSKKKLSQHKEKKATQMLAIVLGVFIICWLPFFIIHILNMHCNCN-IPQALYSAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKILHC------------------------- >OLF8_RAT ---------------MNNKTVITHFLLLGLPIPPEHQQLFFALFLIMYLTTFLGNLLIVVLVQLDSHLHTPMYLFLSNLSFSDLCFSSVTMLKLLQNIQSQVPSISYAGCLTQIFFFLLFGYLGNFLLVAMAYDRYVAICFPLYTNIMSHKLCTCLLLVFWIMTSSHAMMHTLLAARL---SLNFFCDLFKLACSDTYVNELMIHIMGVIIIVIPFVLIVISYAKIISSI--------LKVPSTQSIHKVFSTCGSHLSVVSLFYGTIIGLYLCPSGDN---FSLKGSAMAMMYTVVTPMLNPFIYSLRNRDMKQALIRVTCSKKISLPW------------------ >GASR_MOUSE GSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQP---I-LQCMHL---WPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGTGPPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPSIASLSRLSYT >OPRK_CAVPO LPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVDVD-IIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVAYMRNVDGVNKP >OLFD_CANFA -------------MTEKNQTVVSEFVLLGLPIDPDQRDLFYALFLAMYVTTILGNLLIIVLIQLDSHLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSIPYAGCLTQMYFFLFFGDLESFLLVAMAYDRYVAICFPLYTTIMSPKLCFSLLVLSWVLTMFHAVLHTLLMARL---CPHFFCDMSKLACSDTQVNELVIFIMGGLILVIPFLLIITSYARIVSSI--------LKVPSAIGICKVFSTCGSHLSVVSLFYGTVIGLYLCPSANN---STVKETIMAMMYTVVTPMLNPFIYSLRNKDMKGALRRVICRKKITFSV------------------ >O2F1_HUMAN -------------MGTDNQTWVSEFILLGLSSDWDTRVSLFVLFLVMYVVTVLGNCLIVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAYDRYVAVCDALYSAIMHGGLCARLAITSWVSGFISSPVQTAITFQL---PDHISCELLRLACVDTSSNEVTIMVSSIVLLMTPFCLVLLSYIQIISTI--------LKIQSREGRKKAFHTCASHLTVVALCYGVAIFTYIQPHSSP---SVLQEKLFSVFYAILTPMLNPMIYSLRNKEVKGAWQKLLWKFSGLTSKLAT--------------- >OPS._MOUSE ------------MLSEASDFNSSGSRSEGSVFSRTEHSVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYA--PTGATCTIN--WRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAS-TAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKCQPHLAVPEPSTLPLAPVRI------ >A1AB_RAT HNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRTYRPWTRGGSLE >D4DR_RAT ---MGNSSATGDGGLLAGRGP---ESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPL-RYNQQGQCQLLLIAATWLLSAAVAAPVVCGLN---G-R--TVCCL---------EDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWPAPRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC----------------------- >GP52_HUMAN SRWTEWRILNMSSGIVNASERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFAFHCAPLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCRVFGYIISVLKSVSMACLACISVDRYLAITKPLYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWG---PGY-IFEWCAT-----SWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHFPSDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRV--LDNPTLSFLTTWLAVSNSFCNCVIYSLSNGVFRLGLRRLFETMCTSCMCVKDQEARANSCSI----- >ACTR_MOUSE -------------MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGSFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALYHSIVTMRRTIITLTIIWMFCTGSGITMVIFFS----------------------HHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSH---ARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY---------------------- >SSR4_HUMAN GEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRH-WPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPGGQ-AVACNLQ---WPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR-AGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLVVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLEGAGGAEETALKSKGGAGCM >OPSD_PIG MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFMLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWVMALACAAPPLVGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFSIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWLPYASVAFYIFTHQGSDFGPIFMTIPAFFAKSASIYNPVIYIMMNKQFRNCMLTTLCCGKNPLGDDEASTTTSKTETSQVAPA >GRHR_SHEEP --MANGDSPDQNENHCSAINSSILLTPGSLPTLTLSGKIRVTVTFFLFLLSTIFNTSFLLKLQNWTQKLSKMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPL-AVKSNSKLGQFMIGLAWLLSSIFAGPQLYIFGMIHEG--FSQCVTH--SFPQWWHQAFYNFFTFSCLFIIPLLIMLICNAKIIFTLTRVPHKNQSKNNIPQARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPDMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >DOP1_DROME YDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTDGSPRIG-NLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPLI-KYPTCALD--------LTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHFKVHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNP---------------------- >AA1R_RABIT ----------------------------MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PETYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKAVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLRN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRRQK-ASGDPHKYYGKELKIAKSLALILFLFALSWLPLHILNCVTLFCPSCQKPSILVYTAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCRPAPAGDGDPND--------- >OPSI_ASTFA LNGFEGDNFYIPMSNRTGLVRDPFVYEQYYLAEPWQFKLLACYMFFLICLGLPINGFTLFVTAQHKKLQQPLNFILVNLAVAGMIMVCFGFTITISSAVNGYFYFGPTACAIEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSASHALGGIGFTWFMAMTCAAPPLVGWSRYIPEGLQCSCGPDYYTLNPKYNNESYVIYMFVVHFIVPVTVIFFTYGRLVCTVKSAAAAQQDSASTQKAEKEVTRMVILMVVGFLVAWTPYATVAAWIFFNKGAAFTAQFMAVPAFFSKSSALFNPIIYVLLNKQFRNCMLTTLFCGKNPLGDEESSTVTVSS----VSPA >ACTR_HUMAN -------------MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFFS----------------------HHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSH---TRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW--------------------- >CCR4_RAT IYTSDNYSEEVG-SGDYDSNKEPC---FRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMAD--WYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATSQSARKLLAEKAVYVGVWIPALLLTIPDIIFADVSQ-DG-RYICDRL---YPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLESVVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKG----------GH >OPSD_ANOCA MNGTEGQNFYVPMSNKTGVVRNPFEYPQYYLADPWQFSALAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLGGEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSRYIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKAAAAQQQESATTQKAEREVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQFRNCMIMTLCCGKNPLGDEETSAGTSTVSTSQVSPA >ML1A_CHICK -------MRANGSELNGTVLPRDPPAEGSPRRPPWVTSTLATILIFTIVVDLLGNLLVILSVYRNKKLRNAGNIFVVSLAIADLVVAIYPYPLVLTSVFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLYDKLYSDKNSLCYVGLIWVLTVVAIVPNLFVGS-LQYDP-IYSCTFA------QSVSSAYTIAVVFFHFILPIAIVTYCYLRIWILVIQVRR-PDNNPRLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETRIPEWLFVSSYYMAYFNSCLNAIIYGLLNQNFRREYKKIVVSFCTAKAFFQDSSNSKPSPLITNNNQ >EDG1_HUMAN VKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCI-S--ALSSCSTV------LPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRLTFISKASRSSE-NVALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKEFSRSKSDNSSH >OPS1_DROPS APS---NGSVVDKVTPDMAHLISPYWDQFPAMDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSTIWCCLAPVFWSRYVPEGNLTSCGID--YLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHMNVRSSEDADKSAEGKLAKVALVTISLWFMAWTPYLVINCMGLFKFEG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGK-SSTSEAESKA---- >PAFR_CAVPO ----------------------MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPITAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTN-G--NITRCFEH---YEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQP---VKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDPINHTPVNPIKN >OPSB_MOUSE -----MSGEDDFYLFQNISSVGPWDGPQYHLAPVWAFRLQAAFMGFVFFVGTPLNAIVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYVVICKPFGSIRFNSKHALMVVLATWIIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIIPLSLICFSYSQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMAD---ESDVSSTVSSSKVGPH- >HH2R_CANFA -------------------MISNGTGSSFCLDSPPCRITVSVVLTVLILITIAGNVVVCLAVGLNRRLRSLTNCFIVSLAITDLLLGLLVLPFSAFYQLSCRWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLITPVRVAVSLVLIWVISITLSFLSIHLGWN--RN-TIPKCKVQ--------VNLVYGLVDGLVTFYLPLLVMCITYYRIFKIARDQR--MGSWKAATIGEHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDD-INEAFEAVVLWLGYANSALNPILYATLNRDFRTAYQQLFRCRPASHNAQETSLRRNQSREPMR--- >C3.1_MOUSE --MSTSFPELDLENFEYDDSAEAC---YLGDIVAFGTIFLSVFYALVFTFGLVGNLLVVLALTNSRKPKSITDIYLLNLALSDLLFVATLPFWTHYLISHEG--LHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAASMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKD-----NECLGDYPEVLQEMWPVLRNSEVNILGFALPLLIMSFCYFRIIQTL---------FSCKNRKKARAVRLILLVVFAFFLFWTPYNIMIFLETLKFYNRDLRLALSVTETVAFSHCCLNPFIYAFAGEKFRRYLGHLYRKCLAVLCGHPVHTGRSRQDSILSS-F >ML1._SHEEP ---------MGRTLAVPTPYGCIGCKLPQPDYPPALIVFMFCAMVITIVVDLIGNSMVILAVSKNKKLRNSGNVFVVSLSVADMLVAIYPYPLMLHAMAIGGWDLSKLQCQMVGFITGLSVVGSIFNIMAIAINRYCYICHSLYERIFSVRNTCIYLAVTWIMTVLAVLPNMYIGT-IEYDP-TYTCIFN------YVNNPAFAVTIVCIHFVLPLLIVGFCYVKIWTKVLAARD-AGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINALTVLVAVNPKEKIPNWVYLAAYFIAYFNSCLNAVIYGVLNENFRREYWTIFHAMRHPVLFLSGLLTAQAHTHARARAR >GRPR_MOUSE NCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPQT--FISCAPY---HSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSLPVNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNR--SHSMTSFKSTNP-SA >OPS._HUMAN ------------MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYA--PTGATCTIN--WRKNDRSFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHSD-TESLNRDWSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPLASGRI------ >5HT1_DROME VSYQGITSSNLGDSNTTLVPLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGN--E-G--PICTVC--------QNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRILLGHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETM-HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYPPSQRVMLGDER >CRH2_MOUSE ------MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPWNPRDTTCDY---------RQKALAVSKFLLAFMVPLAIIASSHVAVSLRL---------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHS-QLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSRRASSTATPAST >ML1C_CHICK -------------MERPGSNGSCSGCRLEGGPAARAASGLAAVLIVTIVVDVLGNALVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILSAIFHNGWTMGNIHCQISGFLMGLSVIGSIFNITAIAINRYCYICHSLYDKLFNLKNTCCYICLTWTLTVVAIVPNFFVGS-LQYDP-IYSCTFA------QTVSTSYTITVVVVHFIVPLSIVTFCYLRIWILVIQVHR-QDCKQKIRAADIRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPSKHIPEWLFVLSYFMAYFNSCLNAVIYGLLNQNFRKEYKRILLMLRTPRLLFIDVSKSKPSPAVTNNNQ >5H1F_HUMAN -------------MDFLNSSD-QNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVYARKRTPKHAGIMITIVWIISVFISMPPLFWR----S-R--DECIIK-------HDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLFKHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC----------------------- >GRHR_PIG --MANSASPEQNQNHCSAINSSILLTQGNLPTLTLSPNIRVTVTFFLFLLSTAFNASFLLKLQKWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPL-AVKSNSRLGRFMIGLAWLLSSIFAGPQLYIFRMIHEG--FSQCVTH--SFPQWWHQAFYDFFTFSCLFIIPLLIMLICNAKIMFTLTRVPHNNQSKNNIPRARLRTLKMTVAFAASFIVCWTPYLVLGIWYWFDPEMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >MAS_MOUSE ------MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMR-RNPFTVYITHLSMADISLLFCIFILSIDYALDYESSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIYTSHRPKHQSAFVCALLCALSCLVTTMEYVMCI-DSHS--RSDC-----------RAVIIFIAILSFLVFTPLMLVSSSILVVKIRK----------NTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYW--SAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRTVSIETVV---- >UL33_HCMVA ----------------------------MTGPLFAIRTTEAVLNTFIIFVGGPLNAIVLITQLLTNRGYSTPTIYMTNLYSTNFLTLTVLPFIVLSNQ-WL-LPAGVASCKFLSVIYYSSCTVGFATVALIAADRYR-VLHKRTYARQSYRSTYMILLLTWLAGLIFSVPAAVYTTVVMN-NGHATCVLYVAEEVH-TVLLSWKVLLTMVWGAAPVIMMTWFYAFFYSTV---------QRTSQKQRSRTLTFVSVLLISFVALQTPYVSLMIFNSYATTATLRRTIGTLARVVPHLHCLINPILYALLGHDFLQRMRQCFRGQLLDRRAFLRSQQTNLAAGNNSQSV >CKR5_GORGO ----MDYQVSSPTYDIDYYTSEPC---QKTNVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >PE21_MOUSE --MSPCG-LNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAG-RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFIS--LGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRDRRRSRGPRRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLSSLRSSRHSGFS >A1AB_MESAU HNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRTYRPWTRGGSLE >O3A2_HUMAN ----------MEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGGNLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRLLAICQPLYSTRMSQTVQRMLVAASLACAFTNALTHTVAMSTL---NNHFYCDLPQLSCSSTQLNELLLFAVGFIMAGTPLVLIITAYSHVAAAV--------LRIRSVEGRKKAFSTCGSHLTVVCLFFGRGIFNYMRLGSEE---ASDKDKGVGVFNTVINPMLNPLIYSLRNPDVQGALWQIFLGRRSLTA------------------- >OPSU_CARAU -------MDAWTYQFGNLSKISPFEGPQYHLAPKWAFYLQAAFMGFVFFVGTPLNAIVLFVTMKYKKLRQPLNYILVNISLGGFIFDTFSVSQVFFSALRGYYFFGYTLCAMEAAMGSIAGLVTGWSLAVLAFERYVVICKPFGSFKFGQSQALGAVALTWIIGIGCATPPFWGWSRYIPEGIGTACGPDWYTKNEEYNTESYTYFLLVSCFMMPIMIITFSYSQLLGALRAVAAQQAESASTQKAEKEVSRMVVVMVGSFVVCYGPYAITALYFSYAEDSNKDYRLVAIPSLFSKSSCVYNPLIYAFMNKQFNACIMETVFGKKIDE-----SSESSVSA------- >PAFR_RAT ----------------------MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPITAQATTRKRGITLSLVIWISIAATASYFLATDSTN-G--NITRCFEH---YEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRP---VRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDPANQTPVLPLKN >YYO1_CAEEL ISPNASNYLTYPFDGLCLQKFFYQLQTSLRRFTPYEEIIYTTVYIIISVAAVIGNGLVIMAVVRKKTMRTNRNVLILNLALSNLILAITNIPFLWLPSIDFEFPYSRFFCKFANVLPGSNIYCSTLTISVMAIDRYYSVKKLKASNRKQCFHAVLVSLAIWIVSFILSLPLLLYYETS--MQEVRQCRLVRLPDITQSIQLLMSILQVAFLYIVPLFVLSIFNVKLTRFLKTNDSHLKNNNKTNQRTNRTTSLLIAMAGSYAALWFPFTLITFLIDFELIINLVERIDQTCKMVSMLSICVNPFLYGFLNTNFRHEFSDIYYRYIRCETKSQPAGRIAHHRQDSVYND >OPS1_LIMPO PN-----ASVVDTMPKEMLYMIHEHWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFMMPTMTSNCFAETWILGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAAPLTHKKATLLLLFVWIWSGGWTILPFFGWSRYVPEGNLTSCTVD--YLTKDWSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHNVAANADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIISWAGVFSSGTRLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLACGSGESGSDVKTMEEKPKIPEA- >OPSV_APIME YLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPNPSLHYLLALLYILFTFLALLGNGLVIWIFCAAKSLRTPSNMFVVNLAICDFFMMIKTPIFIYNSFNTG-FALGNLGCQIFAVIGSLTGIGAAITNAAIAYDRYSTIARPL-DGKLSRGQVILFIVLIWTYTIPWALMPVMGVWGRFPEGFLTSCSFD--YLTDTNEIRIFVATIFTFSYCIPMILIIYYYSQIVSHVVNHNVDSNANTSSQSAEIRIAKAAITICFLYVLSWTPYGVMSMIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAISHPKYRLELQKRLPWLELQEKPISDSTSTPPASS------ >5H1B_DIDMA PPASGSLTSSQTNHSTFPNPNAPDLEPYQDSIALPWKVLLATFLGLITLGTTLSNAFVIATVSRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVYSAKRTPKRAAGMIIMVWVFSVSISMPPLFWR------E--ADCSVN-------TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRKVSLEKKKLMAARERKATRTLGIILGAFIVCWLPFFIISLALPICDDAWFHLAIFDFFNWLGYLNSLINPIIYTKSNDDFKQAFQKLMRFRRTS--------------------- >NY2R_PIG EEMKMEPSGPGHTTPRGELAPDSEPELKDSTKLIEVQIILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKRISFLIIGLAWGISALLASPLAIFREYS-FE--IVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYARIWSKLKNHSPG-GVNDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKNLEATKNGG >B1AR_.ENLA WGPMEC--RNRS----GTPTTVPSPMHPLPELTHQWTMGMTMFMAAIILLIVMGNIMVIVAIGRNQRLQTLTNVFITSLACADLIMGLFVVPLGATLVVSGRWLYGSIFCEFWTSVDVLCVTASIETLCVISIDRYIAITSPFYQSLLTKGRAKGIVCSVWGISALVSFLPIMMHWWRDM-K--GCCDFV--------TNRAYAIASSIISFYFPLIIMIFVYIRVFKEAQKQHGRRILSKILVAKEQKALKTLGIIMGTFTLCWLPFFLANVVNVFYRNL-IPDKLFLFLNWLGYANSAFNPIIYCRSP-DFRKAFKRLLCCPKKADRHLHTTGEFVNSLDTN---A >D2DR_HUMAN ---MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC------------------------- >FML2_HUMAN -----------METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMT-RTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFASFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISAFWAVERLNVF------ITMAKVFLILHFIIGFTVPMSIITVCYGIIAAKI---------HRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSATSAS-------- >ACM5_MACMU -------MEGDSYHNATTVNGTPVYHQPLERHRLWEVISIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLYRAKRTPKRAGVMIGLAWLISFILWAPAILCWQYLV-VP-LDECQIQ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRNPSTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYW------------ >PE22_CANFA ----------------MGSISNNSGSEDCESREWLPSGESPAISSAMFSAGVLGNLIALALLARRWRSISLFHVLVTELVFTDLLGTCLISPVVLASYARNQLEPERRACTYFAFAMTFFSLATMLMLFAMALERYLSIGRPYYQRHVTRRGGLAVLPTIYTVSLLFCSLPLLGYGQYVQYCPGTWCFIR--------HGRTAYLQLYATLLLLLIVAVLACNFSVILNLIRMDGSRRGERVSVAEETDHLILLAIMTITFAICSLPFTIFAYMNETSS---RREKWDLQALRFLSINSIIDPWVFAIFRPPVLRLMRSVLCCRVSLRAQDATQTSSRLTFVDTS--- >5H1B_RABIT AAGSQIAVPQANLSAAHSHNCSAEGYIYQDSIALPWKVLLVLLLALFTLATTLSNAFVVATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDLWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPKRAAIMIRLVWVFSICISLPPFFWR----E-E--SECLVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGVFIVCWLPFFIISLVMPICKDAWFHQAIFDFFTWLGYVNSLINPIIYTMSNEDFKQAFHKLIRFKCTS--------------------- >GLHR_ANTEL HSNHTPNGTQFHQCSKIPVQCVPKSDAFHPCEDIMGYVWLTVVSFMVGAVALVANLVVALVLLTSQRRLNVTRFLMCNLAFADFILGLYIFILTSVSAVTRGWQNG-AGCKILGFLAVFSSELSLFTLVMMTIERFYAIVHAMMNARLSFRKTVRFMIGGWIFALVMAVVPLTGVSGY----KVAICLPF-----VSDATSTAYVAFLLLVNGASFISVMYLYSRMLYVVVSG---GDMEGAPKRNDSKVAKRMAILVFTDMLCWAPIAFFGLLAAFGQTLLTVTQSKILLVFFFPINSICNPFLYAFFTKAFKRELFTALSRIGFCKFRALKYNGSRSRRHHSTVNA >MSHR_OVIMO PALGSQRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPNGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFVCCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSVLSITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACRHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >P2YR_CHICK PELLAG-----------GWAAGNATTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTG----KTITCYDT-TADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSLTEYKQNGDTSL >ADMR_MOUSE LEPDNDFRDIHNWTELLHLFNQTFTDCHIEFNENTKHVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAIADLGIILSLPVWMLEVMLYETWLWGSFSCRFIHYFYLVNMYSSIFFLTCLSIDRYVTLTNTSSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLD--E--PMCLFLAPFETYSAWALAVALSATILGFLLPFLLIAVFNILTACRL---------RRQRQTESRRHCLLMWAYIVVFAICWLPYQVTMLLLTLHGTHNLLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRQHSIIITKEGSL >FSHR_BOVIN FDVMYSEFDYDLCNEVVDVTCSPEPDAFNPCEDIMGDDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEVQAQTYRSNFHPRNGHCPPA >B3AR_RAT MAPWPHKNGSLAFWSDAPTLDPSAAN---TSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVQ-E--RCCSFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQGVPRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPS-VPSGVFIALNWLGYANSAFNPLIYCRSP-DFRDAFRRLLCSYGGRGPEEPRVVTSRQNSPLNRFDG >D3DR_CERAE --------MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFN---D-P--TVCSI---------SNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRTSLPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------- >NK2R_MOUSE ----MGAHASVTDTNILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAVIWLVALALASPQCFYST---GA---TKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRPRHHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWGTPTEE----HTPSISRRVNRC >BONZ_MACNE ------MAEHDYHEDYGLNSFNDSSQEEHQDFLQFRKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WIFGQVMCKTLLGVYTINFYTSMLILTCITVDRFIVVVKATNQQAKRMTWGKVICLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DKEISTVVLATQMTLGFFLPLLAMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQTPFNLVKLIRSTHWEYTSFHYTIIVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >NK1R_MOUSE -----MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQGYYST---SR---VVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLE---IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY----STRYLQTQSSVY >O.2R_HUMAN ASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL-MFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTKTTLFTVCDER---WGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRKSRVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLESRKSLTTQISN >IL8A_RABIT WTWFEDEFANATGMPPVEKDYSPC----LVVTQTLNKYVVVVIYALVFLLSLLGNSLVMLVILYSRSNRSVTDVYLLNLAMADLLFALTMPIWAVSKEKG--WIFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFICLGIWALSLILSLPFFLFRQVFS-NS-SPVCYED-LGHNTAKWRMVLRILPHTFGFILPLLVMLFCYGFTLRTL---------FQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTHNDIDRALDATEILGFLHSCLNPIIYAFIGQNFRNGFLKMLAARGLISKEFLTRHR------------ >AG2S_MOUSE ------MILNSSIEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYQWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFVFPFVIILTSYTLIWKALKKA----YKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFSFLDVLIQLGDVVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKARSHAGLSTRPSD-------N >OPSD_ANGAN MNGTEGPNFYIPMSNITGVVRSPFEYPQYYLAEPWAYTILAAYMFTLILLGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTVYTSMHGYFVFGETGCNLEGYFATLGGEISLWSLVVLAIERWVVVCKPMSNFRFGENHAIMGLAFTWIMANSCAMPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFSVPLTIISFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVVIMVIAFLVCWVPYASVAWYIFTHQGSTFGPVFMTVPSFFAKSSAIYNPLIYICLNSQFRNCMITTLFCGKNPFQEEEGASTASSVSS--VSPA >O3A3_HUMAN ----MSLQKLMEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTIGGNLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRLLAICQPLYSTRMSQTVQRMLVAASWACAFTNALTHTVAMSTL---NNHFYCDLPQLSCSSTQLNELLLFVAAAFMAVAPLVFISVSYAHVVAAV--------LQIRSAEGRKKAFSTCGSHLTVVGIFYGTGVFSYMRLGSVE---SSDKDKGVGVFMTVINPMLNPLIYSLRNTDVQGALCQLLVGERSLT-------------------- >GPRC_MOUSE NLSGLPRDCIDAGAPENISAAVPSQGSVAESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAG-LGLIINFVFA-Y--LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCL-R--DESTCSVV-------RPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHIALHFLATSHYVTTRKGVSTLALILGTFAACWMPFTLYSLIADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLSQRARSP------------ >D1DR_CARAU -------------MAVLDLNLTTVIDSGFMESDRSVRVLTGCFLSVLILSTLLGNTLVCAAVTKFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVTEVAGFWPFG-AFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPRVAFVMISGAWTLSVLISFIPVQLKWHKAVN-PTDNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTQIYRIAQKQGSNESSFKLSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKRTCISPTTFDVFVWFGWANSSLNPIIYAFNA-DFRRAFAILLGCQRLCPGSI-SMET------------ >OPS1_SCHGR GG-F-ANQTVVDKVPPEMLYLVDPHWYQFPPMNPLWHGLLGFVIGVLGVISVIGNGMVIYIFSTTKSLRTPSNLLVVNLAFSDFLMMFTMSAPMGINCYYETWVLGPFMCELYALFGSLFGCGSIWTMTMIALDRYNVIVKGLSAKPMTNKTAMLRILFIWAFSVAWTIMPLFGWNRYVPEGNMTACGTD--YLTKDWVSRSYILVYSFFVYLLPLGTIIYSYFFILQAVSAHMNVRSAEASQTSAECKLAKVALMTISLWFFGWTPYLIINFTGIFETMK-ISPLLTIWGSLFAKANAVFNPIVYGISHPKYRAALEKKFPSLACASSSDDNTSVSDEKSEKSASA- >MSHR_CAPCA PVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDMLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >O3A4_HUMAN -----------MDLGNSGNDSVTKFVLLGLTETAALQPILFVIFLLAYVTTIGGTLSILAAILMETKLHSPMYFFLGNLSLPDVGCVSVTVPAMLSHFISNDRSIPYKACLSELFFFHLLAGADCFLLTIMAYDRYLAICQSLYSSRMSWGIQQALVGMSWVFSFTNALTQTVALSPL---NNHFYCDLPQLSCASVHLNGQLLFVAAAFMGVAPLVLITVSYAHVAAAV--------LRIRSAEGKKKAFSTCSSHLTVVGIFYGTGVFSYTRLGSVE---SSDKDKGIGILNTVISPMLNPLIYWTSLLDVGCISHCSSDAGVSPGPPVQSSLCLSPPPGWGGLSP >P70658 IYTSDNYSEEVG-SGDYDSNKEPC---FRDENVHFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMAD--WYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKAVYVGVWIPALLLTIPDFIFADVSQGDD-RYICDRL---YPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLGSIVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKG----------GH >OPSD_AMBTI MNGTEGPNFYVPFSNKSGVVRSPFEYPQYYLAEPWQYSVLAAYMFLLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVFGGFPVTMYSSMHGYFVFGQTGCYIEGFFATMGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVMMTWIMALACAAPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFLVHFTIPLMIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFSNQGTDFGPIFMTVPAFFAKSSAIYNPVIYIVLNKQFRNCMITTICCGKNPFGDDETTSAASSVSSSQVSPA >V2R_PIG -MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDSG--VLDCWAS---FAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSGRRPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKA-REGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQESFSARDTSS--- >5H7_HUMAN GSWAPHLLS---EVTASPAPTNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSSRLERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERPEFVLR >NTR2_RAT -----METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARARPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKH--AASRVCTVL---VSRATLQVFIQVN-VLVSFALPLALTAFLNGITVNHLMALVQARHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQSTYSFRLWGSPR >OPSD_RAJER MNGTEGENFYVPMSNKTGVVRSPFDYPQYYLGEPWMFSALAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLGGEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWSRYIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESESTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQFRNCMITTICLGKNPFEEEESTSAASSVSSSQVAPA >OPSD_CAMAB GGGF-GNQTVVDKVPPEMLHMVDAHWYQFPPMNPLWHALLGFVIGVLGVISVIGNGMVIYIFTTTKSLRTPSNLLVVNLAISDFLMMLCMSPAMVINCYYETWVLGPLFCELYGLAGSLFGCASIWTMTMIAFDRYNVIVKGLSAKPMTINGALIRILTIWFFTLAWTIAPMFGWNRYVPEGNMTACGTD--YLTKDLFSRSYILIYSIFVYFTPLFLIIYSYFFIIQAVAAHMNVRSAENQSTSAECKLAKVALMTISLWFMAWTPYLVINYSGIFETTK-ISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFQKFPSLACTTEPTG-ADTTEGNEKPAA--- >SSR4_MOUSE VED----TTWTPGINASWAPEQEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVRSAAALRH-WPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLTATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPGGE-AVACNLH---WPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALR-GGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEETALKSRGGAGCI >NY1R_.ENLA NFSTYFENLSVPNNISG---NITFPISEDCALPLPMIFTLALAYGAVIILGLSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLATIMCLPFTLIYTLMDHWIFGEVMCKLNEYIQCVSVTVSIFSLVLIAIERHQLIINPR-GWRPNNRHACFGITVIWGFAMACSTPLMMYSVLTDIG--KYVCLED---FPEDKFRLSYTTLLFILQYLGPLCFIFVCYTKIFLRLKRRNMMIRDNKYRSSETKRINIMLLSIVVGFALCWLPFFIFNLVFDWNHEACNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSREDDY---TMHTDVSKTSLK >LSHR_PIG ESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGWQTG-NGCSVAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSY----KVSICLPM-----VETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNP------ELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRK---NGFTGSNK >GPR4_HUMAN --------------------MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLFARLRRVKTAVAVSSVVWATELGANSAPLFHDEL--NH---TFCFEKPMEGWVAWMVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRG------SVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMETPLTSKRNSTA >OPSD_POMMI MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILTGFPINFLTLYVTLEHKKLRTALNLILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLGGEIALWSLVVLAVERWVVVCKPISNFRFTENHAIMGVAFSWIMAATCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFLAPLIVIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLTSWLPYASVAWYIFTHQGTEFGPLFMTIPAFFAKSSALYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >CB1R_POEGU EFYNKSLSTFKDNEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCVMWTIAIVIAVLPLLGWNCK-K--LNSVCSDI------FPLIDETYLMFWIGVTSILLLFIVYAYMYILWKAHSHTEDQITRPDQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTIFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPTCEGTAQPLDNSMEANN-AGNVHRAA >ADMR_HUMAN AVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVE--E--PMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRL---------RQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCAQHSIIITKGDSQ >GPR6_HUMAN G-PPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAG-CGLILHFVFQ-Y--LVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCL-A--ERAACSVV-------RPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHIALHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSH----EDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSP------------ >5H1D_MOUSE SLPNQSLEGLPQEASNRSLNAT---GAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAAAMIAAVWIISICISIPPLFWR----H-E--SDCLVN-------TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRKLALERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKAS--------------------- >OPSD_ORYLA MNGTEGPYFNVPMVNTTGIVRSPYEYPQYYLVSPAAYAALGAYMFFLILVGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLVFTWIMAASCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIGFLVCWLPYASVAWYIFTNQGSEFGPLFMTIPAFFAKSSSIYNPAIYICMNKQFRNCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >YDBM_CAEEL EGAGEDVDHHSLFCPKKLVGNLKGFIRNQYHQHETIQILKGSALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIVLPLSSVYAIAGEWVFPDALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVYMSKRNKRTAGIMILSVWISSALISLAPLLGWKQ--Q-TTVRQCTFL--------DLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHYRKRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIALKRLFTSEKKPSSTSRV--------------- >THRR_MOUSE LLEGRAVYLNISLPPHTPPPPFISEDASGYLTSPWLTLFMPSVYTIVFIVSLPLNVLAIAVFVLRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAAFYGNMYASIMLMTVISIDRFLAVVYPISLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTR--N--TTCHDVLSENLMQGFYSYYFSAFSAIFFLVPLIVSTVCYTSIIRCL------SSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLFLSDEAAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYSILCCKESSDPNSCNSTGDTCS-------- >H218_RAT ----MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAG-VAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCL-D--HLEACSTV------LPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSS-----HADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRCPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGPLRSSSSLERGL >CKR5_MOUSE --MDFQGSVPTYIYDIDYGMSAPC---QKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANE--WIFGNIMCKVFTGVYHIGYFGGIFFIILLTIDRYLAIVHAVALKVRTVNFGVITSVVTWVVAVFASLPEIIFTRSQK-EG-HYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMIICYSGILHTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFNRLDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHIVKRFCKRCSIFV-------SSVY >B3AR_CANFA MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--HCCAFA--------SNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQAVPLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPS-VPSPALLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCR---REEHRAAAAAPAALTSPAES >P2Y5_CHICK -----------------------MVSSNCSTEDSFKYTLYGCVFSMVFVLGLIANCVAIYIFTFTLKVRNETTTYMLNLAISDLLFVFTLPFRIYYFVVRN-WPFGDVLCKISVTLFYTNMYGSILFLTCISVDRFLAIVHPFSKTLRTKRNARIVCVAVWITVLAGSTPASFFQSTNR---EQRTCFENFPESTWKTYLSRIVIFIEIVGFFIPLILNVTCSTMVLRTLNKP----LTLSRNKLSKKKVLKMIFVHLVIFCFCFVPYNITLILYSLMRTQTAVRTMYPVTLCIAVSNCCFDPIVYYFTSDTNSELDKKQQVHQNT---------------------- >GPRO_HUMAN HASRMSVLRAKPMSNSQRLLLLSPGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISTKFRKPSVATLVICLLWALSFISITPVWLYARLIP-FP-AVGCGIR--LPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSV--PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTFVYLYNAAIS-LGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQESKGT------- >THRR_.ENLA SGEGSGDQAPVSRSARKPIRRNITKEAEQYLSSQWLTKFVPSLYTVVFIVGLPLNLLAIIIFLFKMKVRKPAVVYMLNLAIADVFFVSVLPFKIAYHLSGNDWLFGPGMCRIVTAIFYCNMYCSVLLIASISVDRFLAVVYPMSLSWRTMSRAYMACSFIWLISIASTIPLLVTEQTQK--D--TTCHDVLDLKDLKDFYIYYFSSFCLLFFFVPFIITTICYIGIIRSL------SSSSIENSCKKTRALFLAVVVLCVFIICFGPTNVLFLTHYLQEANEFLYFAYILSACVGSVSCCLDPLIYYYASSQCQRYLYSLLCCRKVSEPGSSTGQLDNCS-------- >GHSR_HUMAN SEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVG---T-D-TNECRPT---FAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRGD-VVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSINT------ >CKR3_CAVPO PEEAELETEFPGTTFYDYEFAQPC---FKVSITDLGAQFLPSLFSLVFIVGLLGNITVIVVLTKYQKLKIMTNIYLLNLAISDLLFLFTLPFWTYYVHWNK-WVFGHFMCKIISGLYYVGLFSEIFFIILLTIDRYLAIVHAVALRTRTVTFGIITSVITWVLAVLAALPEFMFYGTQG-HF-VLFCGPSYPEKKEHHWKRFQALRMNIFGLALPLLIMIICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMVVFFVFWTPYNLLLLFSAFDLSFKQLDMAKHVTEVIAHTHCCINPIIYAFVGERFQKYLRHFLHRNVTMHLSKYIPFFS-------SSIS >ADMR_RAT LAPDNDFREIHNWTELLHLFNQTFSDCRMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLYETWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLD--E--PMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRL---------RRQGQTESRRHCLLMWAYIVVFAICWLPYHVTMLLLTLHTTHNFLYFFYEITDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRQHSIIITKEGSL >GPR._MOUSE --------MDLINSSTHVINVSTSLTNSTGVPTPAPKTIIAASLFMAFIIGVISNGLYLWMLQFKMQ-RTVNTLLFFHLILSYFISTLILPFMATSFLQDNHWVFGSVLCKAFNSTLSVSMFASVFFLSAISVARYYLILHPVSQQHRTPHWASRIALQIWISATILSIPYLVFRTTHD-IS--DWESKE-HQTLGQWIHAACFVGRFLLGFLLPFLVIIFCYKRVATKM---------KEKGLFKSSKPFKVMVTAVISFFVCWMPYHVHSGLVLTKSQP-PLHLTLGLAVVTISFNTVVSPVLYLFTGENFKV-FKKSILALFNSTFSDISSTEETEI-------- >CML2_HUMAN APNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHER--YYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQ-A----CFCFA---------DVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVR----AHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHADSTEQSDVRFSS >AA2A_CANFA -------------------------------MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSS-Q-QVACLFE-----DVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQESQGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGAHGSDGEQISLR >NK2R_MESAU ----MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPITKATIAGIWLVALALASPQCFYST---GA---TKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRPRHHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----RTPSLSRRVNRC >PAFR_MOUSE ----------------------MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPITAQATTRKRGISLSLIIWVSIVATASYFLATDSTN-G--NITRCFEH---YEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQP---MRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDPANQTPIVSLKN >GU27_RAT --------------------------------MILNCNPFSGLFLSMYLVTVLGNLLIILAVSSNSHLHNLMYFFLSNLSFVDICFISTTIPKMLVNIHSQTKDISYIECLSQVYFLTTFGGMDNFLLTLMACDRYVAICHPLYTVIMNLQLCALLILMFWLIMFCVSLIHVLLMNEL---NPHFFCELAKVANSDTHINNVFMYVVTSLLGLIPMTGILMSYSQIASSL--------LKMSSSVSKYKAFSTCGSHLCVVSLFYGSATIVYFCSSVLHS---THKKMIASLMYTVISPMLNPFIYSLRNKDVKGALGKLFIRVASCPLWSKDFRPRQSL-------- >ET3R_.ENLA GNVLNMSPP------------PPSPCLSRAKIRHAFKYVTTILSCVIFLVGIVGNSTLLRIIYKNKCMRNGPNVLIASLALGDLFYILIAIPIISISFWLS----TGHSEYIYQLVHLYRARVYSLSLCALSIDRYRAVASWNIRSIGIPVRKAIELTLIWAVAIIVAVPEAIAFNLVELV--ILVCMLPQTSDFMRFYQEVKVWWLFGFYFCLPLACTGVFYTLMSCEMLSINGM-IALNDHMKQRREVAKTVFCLVVIFALCWLPLHVSSIFVRLSATVQLLMVMNYTGINMASLNSCIGPVALYFVSRKFKNCFQSCLCCWCHRPTLTITPMDWKANGHDLDLDR >B3AR_CAPHI MAPWPPRNSSLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLAIVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--RCCTFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPS-VSGPTFLALNWLGYANSAFNPLIYCRSP-DFQSAFRRLLCRCRPEEHLAAASPPRVLTSPAGPRQP >GP41_HUMAN -----------------------MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD--T--GTCYLE-FRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGR--------GGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICG---ESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSGGEEQRADRPAE >O.YR_RAT GTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIRDLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGENSSTFVLSRRSS >OLF2_CHICK -------------MASGNCTTPTTFILSGLTDNPRLQMPLFMVFLVIYTTTLLTNLGLIALIGMDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERRTISYVGCILQYFSFVLLTTSEWLLLAVMAYDRYVAICKPLYPSIMTKAVCWRLVKGLYSLAFLNSLVHTSGLLKL---SNHFFCDNRQISSSSTTLNELLVIISGSLFVMSSIITILISYVFIILTV--------VMIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRSVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRLTATSVWLH-------------------- >NTR1_MOUSE PHPQFGLETMLLALSLSNGSGLEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQN--SGGLVCTPT---VVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMEHSMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPSMSSNHAFSTSA >OLF7_RAT ------------MERRNHSGRVSEFVLLGFPAPAPLRVLLFFLSLL-YVLVLTENMLIIIAIRNHPTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFIGSKQLISFEACMTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLYPVIVSSRLCVQMAAGSWAGGFGISMVKVFLISRL---SNHFFCDVSNLSCTDMSTAELTDFVLAIFILLGPLSVTGASYMAITGAV--------MRIPSAAGRHKAFSTCASHLTVVIIFYAASIFIYARPKALS---AFDTNKLVSVLYAVIVPLFNPIIYCLRNQDVKRALRRTLHLAQDQEANTNKGSK------------ >MC5R_RAT -MNSSSHLTLLDLTLNASEDNILGQNVNNKSSACEDMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETITIYLINNDTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALYHHIMTARRSGVIIACIWTFCISCGIVFIIYYY----------------------EESKYVIVCLISMFFTMLFFMVSLYIHMFLLARNH-RIPRYNSVRQRASMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNACFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIICCHGFRRTCTLLGRY------------ >BONZ_CERAE ------MAEYDHYEDNGFNSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WIFGQVMCKTLLGIYTINFYTSMLILTCITVDRFIVVVKATNQQAKKMTWGKVICLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DEEISTVVLATQMTLGFFLPLLAMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQTPFNLVKLIRSTHWEYTSFHYTIIVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >SSR5_MOUSE LSLASTPSWNAS---AASSGSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSY-WPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQE-----GTCNLS-WPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAMR--VGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIERPQTTLPTRSCE >OPSR_ASTFA GD--DTTREAAFTYTNSNNTKDPFEGPNYHIAPRWVYNLATCWMFFVVVASTVTNGLVLVASAKFKKLRHPLNWILVNLAIADLLETLLASTISVCNQFFGYFILGHPMCVFEGFTVATCGIAGLWSLTVISWERWVVVCKPFGNVKFDGKMATAGIVFTWVWSAVWCAPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCFIPLGIIILCYIAVWWAIRTVAQQQKDSESTQKAEKEVSRMVVVMIMAYCFCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQFRVCIMQLFGKKVDDG-----SEVSS------VAPA >C.C1_HUMAN ------MESSGNPESTTFFYYDLQSQPCENQAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWG--WVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLTLRVPTLRCRVLVTMAVWVASILSSILDTIFHKVLS-----SGCDYS------ELTWYLTSVYQHNLFFLLSLGIILFCYVEILRTL---------FRSRSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQQQLEYALLICRNLAFSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASFAYEGASFY--- >GALT_RAT --------------------MADIQNISLDSPGSVGAVAVPVIFALIFLLGMVGNGLVLAVLLQPGPPRSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLIYLTMYASSFTLAAVSLDRYLAVRHPLSRALRTPRNARAAVGLVWLLAALFSAPYLSYYG---GA--LELCVPA----WEDARRRALDVATFAAGYLLPVAVVSLAYGRTLCFLWAAP--AAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAPATYACRLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGRRRHRHHHR-AHPASSGPAGYPGD >ACM4_HUMAN -----MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-VP-DNHCFIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR---------------- >AG22_RAT RNITSSLPFDNLNATGTNESAFNC----SHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRT-LG--NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSREMD-------T >OPRM_MOUSE LSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIPSTANTVDRTNH >MC4R_HUMAN GMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIIITLLNSQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALYHNIMTVKRVGIIISCIWAACTVSGILFIIYYS----------------------DDSSAVIICLITMFFTMLALMASLYVHMFLMARLH-RIPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY------------ >5H7_CAVPO STWTPRLLSGVPEVAASPSPSNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSSRLERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERPECVLQ >NK2R_HUMAN ----MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWAPAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAGIWLVALALASPQCFYST---GA---TKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRPGHHGANLRHLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKE----PTTSLSTRVNRC >NY1R_CAVPO TSFSQLENHSVHYNLSEEKPSFFAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALILIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWIFGEIMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYIGIAVIWVLAVASSLPFMIYQVLTDKD--KLVCFDQ---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMMRDSKYRSSESKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >O.1R_RAT PGVPTSSGEPFHLPPDYED-EFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSRTRLFSVCDER---WADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQPRFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPS-----RHKS---LSLQS >YTJ5_CAEEL -------------MPNYTVPPDPADTSWDSPYSIPVQIVVWIIIIVLSLETIIGNAMVVMAYRIERNSKQVSNRYIVSLAISDLIIGIEGFPFFTVYVLNGDWPLGWVACQTWLFLDYTLCLVSILTVLLITADRYLSVCHTAYLKWQSPTKTQLLIVMSWLLPAIIFGIMIYGWQAMTQSTSGAECSAP------FLSNPYVNMGMYVAYYWTTLVAMLILYKVFSSGYQKKSQPDRLAPPNKTDTFLSASGTITFIVGFFAILWSPYYIMATVYGFCKG--IPSFLYTLSYYMCYLNSSGNPFAYALANRQFRSAFMRMFRGNFNKVA------------------ >KI01_HUMAN ---------------MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPS-SKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQS-TQ---IKCIEL--KSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFK----LKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIESTDTL------ >PD2R_HUMAN ---------------------MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQ-MVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMAEPGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDV-TSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNST------------ >C3.1_RAT --MPTSFPELDLENFEYDDSAEAC---YLGDIVAFGTIFLSIFYSLVFTFGLVGNLLVVLALTNSRKSKSITDIYLLNLALSDLLFVATLPFWTHYLISHEG--LHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAASMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKD-----NECLGDYPEVLQEIWPVLRNSEVNILGFVLPLLIMSFCYFRIVRTL---------FSCKNRKKARAIRLILLVVVVFFLFWTPYNIVIFLETLKFYNRDLRWALSVTETVAFSHCCLNPFIYAFAGEKFRRYLRHLYNKCLAVLCGRPVHAGRSRQDSILSS-L >UR2R_RAT TVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKD-WHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQ---GS--KSLCLPA----WGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLS---ASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSLQQDSGRSLSSS >5H4_MOUSE ------------------MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIRK-NSTWCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHSRPDQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTINGSTHVLR-- >MC4R_RAT GMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALYHNIMTVRRVGIIISCIWAACTVSGVLFIIYYS----------------------DDSSAVIICLITMFFTMLVLMASLYVHMFLMARLH-RIPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY------------ >OLF2_CANFA -------------MDGKNCSSVNEFLLVGISNKPGVKVTLFITFLIVYLIILVANLGMIILIRMDSQLHTPMYFFLSHLSFSDARYSTAVGPRMLVGFIAKNKSIPFYSCAMQWLVFCTFVDSECLLLAVMAFDRYKAISHPLYTVSMSSRVCSLLMAGVYLVGIMDASVNTILTFRL---CNHFFCDVPLLSCSDTQVNELVIFTIFGFIELITLSGLFVSYCYIILAV--------RKINSAEGRFKAFSTCTSHLTAVAIFQGTMLFMYFRPSSSY---SLDQDKIISLFYSLVIPMLNPLIYSLRNKDVKEALKKLKNKKWFH--------------------- >AG2S_.ENLA ----MLSNISAGENSEVEKIVVKC---SKSGMHNYIFITIPIIYSTIFVVGVFGNSLVVIVIYSYMKMKTMASVFLMNLALSDLCFVITLPLWAVYTAMHYHWPFGDLLCKIASTAITLNLYTTVFLLTCLSIDRYSAIVHPMSRIRRTVMVARLTCVGIWLVAFLASLPSVIYRQIFI-TN--TVCALV-YHSGHIYFMVGMSLVKNIVGFFIPFVIILTSYTLIGKTLKEV------YRAQRARNDDIFKMIVAVVLLFFFCWIPHQVFTFLDVLIQMDDIVDTGMPITICIAYFNSCLNPFLYGFFGKKFRKHFLQLIKYIPPKMRTHASVNTRLSD-------T >OPRD_MOUSE SSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPGA---VVCMLQ-FPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL-SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRVTACTPSDGPG >CKR5_PYGNE ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLIMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OPSD_GAMAF MNGTEGPYFYVPMVNTTGIVRSPYEYPQYYLVSPAAYACLGAYMFFLILVGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNLEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFTENHAIMGLVFTWIMANACAAPPLLGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFICHFCIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVILVIGFLVCWTPYASVAWYIFSNQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >LSHR_CALJA ESGQSGWDYDYGFHLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCNTAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----KVSICFPM-----VETTLSQIYILTILILNVVAFIIICACYIKIYFAVRNP------ELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKMPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFRRDFFLLLGKFGCCKHRAELYRRSNYKNGFTGSSK >O1F1_HUMAN -------------MSGTNQSSVSEFLLLGLSRQPQQQHLLFVFFLSMYLATVLGNLLIILSVSIDSCLHTPMYFFLSNLSFVDICFSFTTVPKMLANHILETQTISFCGCLTQMYFVFMFVDMDNFLLAVMAYDHFVAVCHPLYTAKMTHQLCALLVAGLWVVANLNVLLHTLLMAPL---STHFFCDVTKLSCSDTHLNEVIILSEGALVMITPFLCILASYMHITCTV--------LKVPSTKGRWKAFSTCGSHLAVVLLFYSTIIAVYFNPLSSH---SAEKDTMATVLYTVVTPMLNPFIYSLRNRYLKGALKKVVGRVVFSV-------------------- >GALT_HUMAN --------------------MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLSRALRTPRNARAAVGLVWLLAALFSAPYLSYYG---GA--LELCVPA----WEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAP--AAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRGPPGCPGDARPS >A2AA_CAVPO ----MGSLQPDSGNASWNGTEGPGGGTRATPYSLQVTVTLVCLVGLLILLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEK-AQ-P--PRCEIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRRGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >A2AA_RAT ----MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGQ-P--PSCKIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRRAGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCP--VPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >OLF4_CANFA -------------MELENDTRIPEFLLLGFSEEPKLQPFLFGLFLSMYLVTILGNLLLILAVSSDSHLHTPMYFFLANLSFVDICFTCTTIPKMLVNIQTQRKVITYESCIIQMYFFELFAGIDNFLLTVMAYDRYMAICYPLYMVIMNPQLCSLLLLVSWIMSALHSLLQTLMVLRL---SPHFFCELNQLACSDTFLNNMMLYFAAILLGVAPLVGVLYSYFKIVSSI--------RGISSAHSKYKAFSTCASHLSVVSLFYCTSLGVYLSSAAPQ---STHTSSVASVMYTVVTPMLNPFIYSLRNKDIKGALNVFFRGKP----------------------- >SSR2_RAT QFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDLNETTETQRTLL >BRS3_SHEEP QTLISTTNDTESSSSVVPNDSTNKRRTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDVTHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPPNAILKTCAKAGCIWIMSMIIALPEAIFSNVYTVT--FKACASY---VSERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSIPTQRHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYRSFTSQTTVHLFVTIISRILAFSNSCVNPFALYWLSNTFQQHFKAQLFCCKAGRPDPTAANTMGRVPGAASTQM >ETBR_BOVIN SSATPQIPRGGRMAGIPPR--TPPPCDGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAKDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDIITRI--LRICLLHQKTAFMQFYKTAKDWWLFSFYFCLPLAITALFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFE-EKQSLEFKANDHGYDNFR >FML1_HUMAN -----------METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMT-RTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTASWPEERLKVA------ITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKI---------HKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTAS---------- >V1AR_MOUSE SSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFVLSIPQYFIFSVIETK--AQDCWAT---FIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHIWRNLLVVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSTSYSNNRSPTNS >OPSB_BOVIN --MSKMSEEEEFLLFKNISLVGPWDGPQYHLAPVWAFHLQAVFMGFVFFVGTPLNATVLVATLRYRKLRQPLNYILVNVSLGGFIYCIFSVFIVFITSCYGYFVFGRHVCALEAFLGCTAGLVTGWSLAFLAFERYIIICKPFGNFRFSSKHALMVVVATWTIGIGVSIPPFFGWSRFVPEGLQCSCGPDWYTVGTKYYSEYYTWFLFIFCYIVPLSLICFSYSQLLGALRAVAAQQQESASTQKAEREVSHMVVVMVGSFCLCYTPYAALAMYIVNNRNHGVDLRLVTIPAFFSKSACVYNPIIYCFMNKQFRACIMEMVCGKPMTD---ESELSSTVSSSQVGPN- >APJ_MOUSE -----------MEDDGYNYYGADNQSECDYADWKPSGALIPAIYMLVFLLGTTGNGLVLWTVFRTSRKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVNARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDAQCY-MDYSMVA-TSNSEWAWEVGLGVSSTAVGFVVPFTIMLTCYFFIAQTIAGHFR--KERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLIFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCDQSGCKGTPHSSSSSGHSQGPGPNM >O1G1_HUMAN -------------MEGKNLTSISECFLLGFSEQLEEQKPLFGSFLFMYLVTVAGNLLIILVIITDTQLHTPMYFFLANLSLADACFVSTTVPKMLANIQIQSQAISYSGCLLQLYFFMLFVMLEAFLLAVMAYDCYVAICHPLYILIMSPGLCIFLVSASWIMNALHSLLHTLLMNSL---SPHFFCDINSLSCTDPFTNELVIFITGGLTGLICVLCLIISYTNVFSTI--------LKIPSAQGKRKAFSTCSSHLSVVSLFFGTSFCVDFSSPSTH---SAQKDTVASVMYTVVTPMLNPFIYSLRNQEIKSSLRKLIWVRKIHSP------------------- >CKR2_HUMAN FIRNTNESGEEVTTFFDYDYGAPC---HKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANE--WVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQK-ED-VYVCGPY----FPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTL--------LRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPV-------KVTT >5H2A_CRIGR NSSDASNWTIDGENRTNLSFEGYLPPTCLSILHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGVSMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESHVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILAYKSSQLQAGQN >TRFR_MOUSE ------------MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--NA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNLNLNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVKESDRFSTELED >OPSH_CARAU MNGTEGNNFYVPLSNRTGLVRSPFEYPQYYLAEPWQFKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGAIMVCFGFTVTFYTAINGYFALGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSSTHASAGIAFTWVMAMACAAPPLVGWSRYIPEGIQCSCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKAAAAQQQDSASTQKAEREVTKMVILMVLGFLVAWTPYATVAAWIFFNKGAAFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTLFCGKNPLGDEESSTVSS------VSPA >A2AB_RAT --------------------MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPCRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCELN--------QEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSGVAWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW------------------ >TA2R_CERAE --MWPNG-----------SSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQTRSSFLTFLCGLVLTDFLGLLVTGAIVVSQHAALFVDPGCRLCRFMGVVMIFFGLSPLLLGATMASERFLGITRPFRPVVTSQRRAWATVGLVWAAALALGLLPLLGLGRYTVQYPGSWCFLT----LGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGEAAQQRPRDSEVEMMAQLLGIMLVASVCWLPLLVFIAQTVLRNPPRATEQELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQ------------ >SSR2_HUMAN PLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDLNETTETQRTLL >ACM4_.ENLA ----MENDTWENESSASNHSIDETIVEIPGKYQTMEMIFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYSLYIIKGYWPLGPIVCDLWLALDYVVSNASVMNLLIISLER-FCVTKPLYPARRTTKMAGLMIAAAWLLSFELWAPAILFWQFIV-VP-SGECYIQ------FLSNPAVTFGTAIAAFYLPVVIMTILYIHISLASRSRSIAVRKKRQMAAREKKVTRTIFAILLAFIITWTPYNVMVLINTFCQTC-IPETIWYIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYKSIGTAR---------------- >Y..5_CAEEL SVNESCDNYVEIFNKINYFFRDDQVINGTEYSPKEFGYFITFAYMLIILFGAIGNFLTIIVVILNPAMRTTRNFFILNLALSDFFVCIVTAPTTLYTVLYMFWPFSRTLCKIAGSLQGFNIFLSTFSIASIAVDRYVLIIFPT-KRERQQNLSFCFFIMIWVISLILAVPLLQASDLTPCDLALYICHEQEIWEKMIISKGTYTLAVLITQYAFPLFSLVFAYSRIAHRMKLRTTNSQRRRSVVERQRRTHLLLVCVVAVFAVAWLPLNVFHIFNTFELVN-FSVTTFSICHCLAMCSACLNPLIYAFFNHNFRIEFMHLFDRVGLRSLRVVIFGEMRTEFRSRGGCK >GRHR_CLAGA TLLLSNPTNVLDNSSVLNVSVSPPVLKWETPTFTTAARFRVAATLVLFVFRAASNLSVLLSVTRGRGLASHLRPLIASLASADLVMTFVVMPLDAVWNVTVQWYAGDAMCKLMCFLKLFAMHSAAFILVVVSLDRHHAILHPL-DTLDAGRRNRRMLLTAWILSLLLASPQLFIFRAIKVD--FVQCATH--SFQQHWQETAYNMFHFVTLYVFPLLVMSLCYTRILVEINRQGEPRSGTDMIPKARMKTLKMTIIIVASFVICWTPYYLLGIWYWFQPQMVIPDYVHHVFFVFGNLNTCCDPVIYGFFTPSFRADLSRCFCWRNQNASAKSLPHFSGEAESDLGSGD >CKR5_HUMAN ----MDYQVSSPIYDINYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OPSD_NEOSA MNGTEGPYFYVPMVNTTGVVRSPYEYPQYYLVNPAAFAVLGAYMFFLIIFGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVIGGFTTTMYSSMHGYFVLGRLGCNLEGFSATLGGMISLWSLAVLAIERWVVVCKPTSNFRFGENHAIMGVSLTWTMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFFCHFMVPLIIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVILMVIGYLVCWLPYASVAWFIFTHQGSEFGPLFMTIPAFFAKSSSIYNPVIYICMNKQFRNCMITTLFCGKNPF---EGEEETEASSASSVSPA >A2AB_HUMAN -------------------------MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCKLN--------QEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSGAIWWRRRAHVTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW------------------ >CKR4_MOUSE VTDTTQDETVYNSYYFYESMPKPC---TKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQ--WVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT-EH-HTYCKTQ-YSVNSTTWKVLSSLEINVLGLLIPLGIMLFWYSMIIRTL---------QHCKNEKKNRAVRMIFGVVVLFLGFWTPYNVVLFLETLVELERYLDYAIQATETLGFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFMS------SSSY >A1AD_HUMAN GSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEP--VP--RFCGIT--------EEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTHTFLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRASTSG-LRQDCA >C3AR_HUMAN --------------MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQ-RTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPICQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFT-ED-YNLGQFT-DDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRM--------QRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPEKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSVIS--------- >AG2R_HUMAN ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTRPSD-------N >CKR5_PANTR ----MDYQVSSPIYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >PF2R_MOUSE --MSMNS---------SKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYN--TEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELKVAAISESPAA >OPSB_ORYLA VEFPDDFWIPIPLDTNNVTALSPFLVPQDHLGSPTIFYSMSALMFVLFVAGTAINLLTIACTLQYKKLRSHLNYILVNMAVANLIVASTGSSTCFVCFAFKYMVLGPLGCKIEGFTAALGGMVSLWSLAVIAFERWLVICKPLGNFVFKSEHALLCCALTWVCGLCASVPPLVGWSRYIPEGMQCSCGPDWYTTGNKFNNESFVMFLFCFCFAVPFSIIVFCYSQLLFTLKMAAKAQADSASTQKAEKEVTRMVVVMVVAFLVCYVPYASFALWVINNRGQTFDLRLATIPSCVSKASTVYNPVIYVLLNKQFRLCMKKMLGMSADED---EESSTSKVGPS------ >CCKR_RABIT ASLLGNASGIPPPCELGLDNETLFCLDQPPPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAISDLMLCLFCMPFNLIPNLLKDFIFGSALCKTTTYLMGTSVSVSTLNLVAISLERYGAICKPLSRVWQTKSHALKVIAATWCLSFAIMTPYPIYN----NNQTANMCRFL---LPSDVMQQAWHTFLLLILFLIPGIVMMVAYGMISLELYQGRVSSSSSAATLMAKKRVIRMLMVIVVLFFLCWMPIFSANAWRAYDTVSRLSGTPISFILLLSYTSSCVNPIIYCFMNRRFRLGFMATFPCCPNPGPPGPRAEATTRASLSRYSYS >BRB1_HUMAN SSWPPLELQSSNQSQLFPQNATAC--DNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMSGRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA-LN--TACILL---LPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTR---VSRTRVRGPKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPK---------LAPI-------S >TRFR_RAT ------------MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNMNLNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVKESDRFSTELDD >AG22_HUMAN KNITSGLHFGLVNISGNNESTLNC----SQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRT-LG--NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSREME-------T >VU51_HSV7J -----------------MKNIDLTNWKLLAEIYEYLFFFSFFFLCLLVIIVVKFNNSTVGR-E--------YTFSTFSGMLVYILLLPVKMGMLTKM-----WDVSTDYCIILMFLSDFSFIFSSWALTLLALERINNFSFSEIKVNETKILKQMSFPIIWVTSIFQAVQISMKYKKSQ---EDDYCLLA--------IRSAEEAWILLMYTVVIPTFIVFFYVLNKRFL-----------FLERDLNSIVTHLSLFLFFGALCFFPASVLNEFNCN----RLFYGLHELLIVCLELKIFYVPTMTYIISCENYRLAAKAFFCKCFKPCFLMPSLRSTQF-------- >PAR3_MOUSE -WTGATTTIKAECPEDSISTLHVNNATIGYLRSSLSTQVIPAIYILLFVVGVPSNIVTLWKLSLRTK-SISLVIFHTNLAIADLLFCVTLPFKIAYHLNGNNWVFGEVMCRITTVVFYGNMYCAILILTCMGINRYLATAHPFYQKLPKRSFSLLMCGIVWVMVFLYMLPFVILKQEYH--E--TTCHDVDACESPSSFRFYYFVSLAFFGFLIPFVIIIFCYTTLIHKL----------KSKDRIWLGYIKAVLLILVIFTICFAPTNIILVIHHANYYYDSLYFMYLIALCLGSLNSCLDPFLYFVMSKVVDQLNP------------------------------ >GPRC_HUMAN NLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAG-IGLITNFVFA-Y--LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCL-R--DESTCSVV-------RPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHIALHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSP------------ >BRB2_CAVPO ---MFNITSQVSALNATLAQGNSC---LDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKD-HN--TACLII---YPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNN---EMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQLRTS-------I >P2YR_RAT AAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTG----KTVTCYDS-TSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLSEFKQNGDTSL >PF2R_SHEEP --MSTNN---------SVQPVSPASELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYK--TDQIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELKVAAISDLPVT >GPRO_RAT QTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISTKFRKPSMATLVICLLWALSFISITPVWLYARLIP-FP-AVGCGIR--LPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSV--PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTFVYLYNAAIS-LGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQESKGT------- >ML1._HUMAN ---------MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT-IEYDP-TYTCIFN------YLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD-AGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFPGLISARTLARARAHAR >AVT_CATCO -------------MGRIANQTTASNDTDPFGRNEEVAKMEITVLSVTFFVAVIGNLSVLLAMHNTKKKSSRMHLFIKHLSLADMVVAFFQVLPQLCWEITFRFYGPDFLCRIVKHLQVLGMFASTYMMVMMTLDRYIAICHPLKTLQQPTQRAYIMIGSTWLCSLLLSTPQYFIFSLSESY--VYDCWGH---FIEPWGIRAYITWITVGIFLIPVIILMICYGFICHSIWKNMIGVSSVTIISRAKLRTVKMTLVIVLAYIVCWAPFFIVQMWSVWDENFDSENAAVTLSALLASLNSCCNPWIYMLFSGHLLYDFLRCFPCCKKPRNMLQKEDSTLLTKLAAGRMT >ACM3_PIG N---------ISQAAGNFSSPNGTTSDPLGGHTIWQVVFIAFLTGILALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFILWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQHKRVPEQAL--- >MSHR_ALCAA PVLGSQRRLLGSLNCTPPATFSLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAMDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAILYVHMLARACQHIARKRQHPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >GP72_MOUSE TGPNASSHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPL-KPRISITKGVIYIAVIWVMATFFSLPHAICQKLFT--EVRSLCLPD-FPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCGDVTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAI-HTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPVAWTEKSHGRRA >ACM5_RAT --------MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLV-VP-PDECQIQ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRNLSTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC-VPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYW------------ >CKR5_PONPY ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >GASR_CANFA GASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVVCKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVIIATWMLSGLLMVPYPVYTAVQP---A-LQCVHR---WPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGPGPPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANTWRAFDSSGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRPLPSIASLSRLSYT >TLR2_DROME TLSTDQPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPL-QPRMSKRCNLAIAAVIWLASTLISCPMMIIYR----NR--TVCYPEDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSTIGTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAIPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRYSCSGSPDHNRI >D2DR_MELGA ------MDPLNLSWYNTGDRNWSEPVNESSADQKPQYNYYAVLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAAAMPMNTRYSSKRRVTVMIACVWVLSFAISSPILFGLN---E----RECII---------ANPAFVVYSSVVSFYVPFIVTLLVYVQIYMVLRRRSTLMNRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCN-IPPAMYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC------------------------- >EDG2_BOVIN QPQFTAMNEQQCFSNESIAFFYNRSGKYLATEWNTVTKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTVSVANLLAIAIERHITVFRMQLHARMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIENCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENTSGPTEGSNHTILAGVHSND >NY2R_BOVIN EEMKVDQFGPGHTTLPGELAPDSEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKQISFLIIGLAWGVSALLASPLAIFREYSLFE--IVACTEKWPGEEKGIYGTIYSLSSLLILYVLPLGIISFSYTRIWSKLKNHSPG-AAHDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKHLQVTKNNG >HH1R_RAT ----------MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFM--EL-EDKCETD------FYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHLRSQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSC-CSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS-----------------------""" gpcr_aln = DenseAlignment(data=gpcr_ungapped.split('\n'),MolType=PROTEIN) myos_data = """>gi|107137|pir||A37102 LSRIITRIQA >gi|11024712|ref|NP-060003.1| LAQLITRTQA >gi|11276950|pir||A59286 LSRIITRIQA >gi|11276952|pir||A59293 LAQLITRTQA >gi|11276954|pir||A59234 LSLIITRIQA >gi|11276955|pir||A59236 LSSIFKLIQA >gi|11321579|ref|NP-003793.1| LVTLMTSTQA >gi|11342672|ref|NP-002461.1| LAKLITRTQA >gi|1197168|dbj|BAA08111.1| LSSIFKLIQA >gi|12003423|gb|AAG43570.1|AF21 LVTLMTRTQA >gi|12003425|gb|AAG43571.1|AF21 LVTLMTRTQA >gi|12003427|gb|AAG43572.1|AF21 LVTLMTRTQA >gi|12053672|emb|CAC20413.1| LSRIITRIQA >gi|12060489|dbj|BAB20630.1| LSRIITRIQA >gi|12657350|emb|CAC27776.1| LASLVTLTQA >gi|12657354|emb|CAC27778.1| LAKLVTMTQA >gi|127741|sp|P02563|MYH6-RAT LSRIITRIQA >gi|127748|sp|P02564|MYH7-RAT LSRIITRIQA >gi|127755|sp|P12847|MYH3-RAT LAKLITRTQA >gi|1289512|gb|AAC59911.1| LSLIITRIQA >gi|1289514|gb|AAC59912.1| LSLIITRIQA >gi|13431707|sp|Q28641|MYH4-RAB LAQLITRTQA >gi|13431711|sp|Q90339|MYSS-CYP LALLVTMTQA >gi|13431716|sp|Q9UKX2|MYH2-HUM LAQLITRTQA >gi|13431717|sp|Q9UKX3|MYHD-HUM LVTLMTSTQA >gi|13431724|sp|Q9Y623|MYH4-HUM LAQLITRTQA >gi|1346637|sp|P02565|MYH3-CHIC LAQLITRTQA >gi|13560269|dbj|BAB40920.1| LAQLMTRTQA >gi|13560273|dbj|BAB40922.1| LSRIITRIQA >gi|13638390|sp|P12882|MYH1-HUM LAQLITRTQA >gi|14017756|dbj|BAB47399.1| LSLIITRIQA >gi|15384839|emb|CAC59753.1| LATLVTMTQA >gi|1581130|prf||2116354A LSRIITRIQA >gi|1619328|emb|CAA27817.1| LAKLITRTQA >gi|16508127|gb|AAL17913.1| LSRIITRIQA >gi|1698895|gb|AAB37320.1| LSRIITRIQA >gi|17907763|dbj|BAB79445.1| LAKILTMLQA >gi|179508|gb|AAA51837.1| LSRIITRIQA >gi|179510|gb|AAA62830.1| LSRIITRIQA >gi|18859641|ref|NP-542766.1| LSRIITRIQA >gi|191618|gb|AAA37159.1| LSRIITRIQA >gi|191620|gb|AAA37160.1| LSRIITRIQA >gi|191622|gb|AAA37161.1| LSRIITRIQA >gi|191624|gb|AAA37162.1| LSRIITRIQA >gi|2119306|pir||I49464 LSRIITRIQA >gi|2119307|pir||I48175 LSRIITRIQA >gi|2119308|pir||I48153 LSRIITRIQA >gi|212376|gb|AAA48972.1| LAQLITRTQA >gi|21623523|dbj|BAC00871.1| LAALVGMVQA >gi|21743235|dbj|BAB40921.2| LAQLITRTQA >gi|21907898|dbj|BAC05679.1| LAQIITRTQA >gi|21907900|dbj|BAC05680.1| LAQIITRTQA >gi|21907902|dbj|BAC05681.1| LSRIITRIQA >gi|219524|dbj|BAA00791.1| LSRIITRIQA >gi|22121649|gb|AAM88909.1| LAQIITRTQA >gi|23379831|gb|AAM88910.1| LAQLITRTQA >gi|2351219|dbj|BAA22067.1| LSHLVTMTQA >gi|2351221|dbj|BAA22068.1| LVNLVTMTQA >gi|2351223|dbj|BAA22069.1| LALLVTMTQA >gi|27764861|ref|NP-002462.1| LSRIITRMQA >gi|297024|emb|CAA79675.1| LSRIITRMQA >gi|3024204|sp|Q02566|MYH6-MOUS LSRIITRIQA >gi|3041706|sp|P13533|MYH6-HUMA LSRIITRMQA >gi|3041708|sp|P13540|MYH7-MESA LSRIITRIQA >gi|3043372|sp|P11055|MYH3-HUMA LAKLITRTQA >gi|34870884|ref|XP-213345.2| LAQLITRTQA >gi|34870892|ref|XP-340820.1| LAQIITRTQA >gi|37720046|gb|AAN71741.1| LARILTGIQA >gi|38091410|ref|XP-354614.1| LAKLITRTQA >gi|38091413|ref|XP-354615.1| LAQLITRTQA >gi|38177589|gb|AAF00096.2|AF11 LSLIISGIQA >gi|38347761|dbj|BAD01606.1| LSLLLTRTQA >gi|38347763|dbj|BAD01607.1| LSLLLTRTQA >gi|38488753|ref|NP-942118.1| LARILTGIQA >gi|3915779|sp|P13539|MYH6-MESA LSRIITRIQA >gi|402372|gb|AAA62313.1| LSRIITRIQA >gi|402374|gb|AAB59701.1| LSRIITRIQA >gi|41350446|gb|AAS00505.1| LAALVTMTQA >gi|41386691|ref|NP-776542.1| LAQLITRTQA >gi|41386711|ref|NP-777152.1| LSRIITRIQA >gi|42476190|ref|NP-060004.2| LAQLITRTQA >gi|42662294|ref|XP-371398.2| LAKVLTLLQA >gi|45382109|ref|NP-990097.1| LAKILTMIQA >gi|45383005|ref|NP-989918.1| LAKILTMLQA >gi|45383668|ref|NP-989559.1| LAQLITRTQA >gi|4557773|ref|NP-000248.1| LSRIITRIQA >gi|45595719|gb|AAH67305.1| LAQLITRTQA >gi|476355|pir||A46762 LSRIITRIQA >gi|4808809|gb|AAD29948.1| LVTLMTSTQA >gi|4808811|gb|AAD29949.1| LAQLITRTQA >gi|4808813|gb|AAD29950.1| LAQLITRTQA >gi|4808815|gb|AAD29951.1| LAQLITRTQA >gi|5360746|dbj|BAA82144.1| LAQLITRTQA >gi|5360748|dbj|BAA82145.1| LAQLITRTQA >gi|5360750|dbj|BAA82146.1| LAQLITRTQA >gi|547966|sp|P12883|MYH7-HUMAN LSRIITRIQA >gi|56655|emb|CAA34064.1| LSRIITRIQA >gi|6093461|sp|P79293|MYH7-PIG LSRIITRIQA >gi|6683485|dbj|BAA89233.1| LAQLITRTQA >gi|6708502|gb|AAD09454.2| LAKIMTMLQC >gi|7209643|dbj|BAA92289.1| LATLVTMTQA >gi|7248371|dbj|BAA92710.1| LAKILTMIQA >gi|7669506|ref|NP-005954.2| LAQLITRTQA >gi|8393804|ref|NP-058935.1| LSRIITRIQA >gi|8393807|ref|NP-058936.1| LSRIITRIQA >gi|86358|pir||A29320 LAQLITRTQA >gi|88201|pir||S04090 LAKLITRTQA >gi|92498|pir||S06005 LSRIITRIQA >gi|92499|pir||S06006 LSRIITRIQA >gi|92509|pir||A24922 LAKLITRTQA >gi|940233|gb|AAA74199.1| LAQLITRTQA >gi|9800486|gb|AAF99314.1|AF272 LAQLITRTQA >gi|9800488|gb|AAF99315.1|AF272 LAQLITRTQA >gi|9971579|dbj|BAB12571.1| LAALVTMTQA""" myos_aln = DenseAlignment(data=myos_data.split('\n'),MolType=PROTEIN) # a randomly generated tree to use in tests tree20_string='(((0:0.5,1:0.5):0.5,(((2:0.5,3:0.5):0.5,(4:0.5,(5:0.5,6:0.5):0.5):0.5):0.5,((7:0.5,8:0.5):0.5,((9:0.5,((10:0.5,11:0.5):0.5,12:0.5):0.5):0.5,13:0.5):0.5):0.5):0.5):0.5,(((14:0.5,(15:0.5,16:0.5):0.5):0.5,17:0.5):0.5,(18:0.5,19:0.5):0.5):0.5);' default_gctmpca_aa_sub_matrix_lines = default_gctmpca_aa_sub_matrix.split('\n') default_gctmpca_aa_sub_matrix = {} for aa,line in zip(gctmpca_aa_order,default_gctmpca_aa_sub_matrix_lines): default_gctmpca_aa_sub_matrix[aa] = dict([(col_aa,float(rate)/100.) \ for col_aa,rate in zip(gctmpca_aa_order,line.split())]) if __name__ == "__main__": main()