from os import environ, remove from tempfile import NamedTemporaryFile, mktemp from unittest import TestCase from numpy import ( arange, array, e, greater_equal, less_equal, log, nan, sqrt, zeros, ) from numpy.testing import assert_allclose, assert_equal from cogent3 import ( DNA, PROTEIN, RNA, load_aligned_seqs, make_aligned_seqs, make_tree, ) from cogent3.core.alignment import ArrayAlignment from cogent3.core.alphabet import CharAlphabet from cogent3.evolve.coevolution import ( DEFAULT_NULL_VALUE, AAGapless, aln_position_pairs_cmp_threshold, aln_position_pairs_ge_threshold, aln_position_pairs_le_threshold, ancestral_state_alignment, ancestral_state_pair, ancestral_state_position, ancestral_states_input_validation, build_coevolution_matrix_filepath, calc_pair_scale, coevolution_matrix_to_csv, coevolve_alignment, coevolve_alignments, coevolve_alignments_validation, coevolve_pair, coevolve_position, count_ge_threshold, count_le_threshold, csv_to_coevolution_matrix, filter_exclude_positions, filter_non_parsimony_informative, filter_threshold_based_multiple_interdependency, freqs_from_aln, freqs_to_array, get_allowed_perturbations, get_ancestral_seqs, get_dg, get_dgg, get_positional_frequencies, get_positional_probabilities, get_subalignments, identify_aln_positions_above_threshold, ignore_excludes, is_parsimony_informative, join_positions, ltm_to_symmetric, make_weights, merge_alignments, mi, mi_alignment, mi_pair, mi_position, n_random_seqs, nmi, nmi_alignment, nmi_pair, nmi_position, normalized_mi, parse_coevolution_matrix_filepath, pickle_coevolution_result, probs_from_dict, protein_dict, resampled_mi_alignment, sca_alignment, sca_input_validation, sca_pair, sca_position, unpickle_coevolution_result, validate_alignment, validate_alphabet, validate_ancestral_seqs, validate_position, validate_tree, ) from cogent3.maths.stats.number import CategoryCounter from cogent3.parse.fasta import MinimalFastaParser def _fasta_to_dict(data): return dict(MinimalFastaParser(data.splitlines())) class CoevolutionTests(TestCase): """Tests of coevolution.py""" def setUp(self): """Set up variables for us in tests""" self.run_slow_tests = int(environ.get("TEST_SLOW_APPC", 0)) # Data used in SCA tests self.dna_aln = ArrayAlignment( data=list(zip(list(range(4)), ["ACGT", "AGCT", "ACCC", "TAGG"])), moltype=DNA, ) self.rna_aln = ArrayAlignment( data=list(zip(list(range(4)), ["ACGU", "AGCU", "ACCC", "UAGG"])), moltype=RNA, ) self.protein_aln = ArrayAlignment( data=list(zip(list(range(4)), ["ACGP", "AGCT", "ACCC", "TAGG"])), moltype=PROTEIN, ) self.dna_aln_gapped = ArrayAlignment( data=list(zip(list(range(4)), ["A-CGT", "AGC-T", "-ACCC", "TAGG-"])), moltype=DNA, ) self.freq = ArrayAlignment( data=list( zip( list(range(20)), [ "TCT", "CCT", "CCC", "CCC", "CCG", "CC-", "AC-", "AC-", "AA-", "AA-", "GA-", "GA-", "GA-", "GA-", "GA-", "G--", "G--", "G--", "G--", "G--", ], ) ), moltype=PROTEIN, ) self.two_pos = ArrayAlignment( data=list( zip( list(map(str, list(range(20)))), [ "TC", "CC", "CC", "CC", "CC", "CC", "AC", "AC", "AA", "AA", "GA", "GA", "GA", "GA", "GA", "GT", "GT", "GT", "GT", "GT", ], ) ), moltype=PROTEIN, ) self.tree20 = make_tree(treestring=tree20_string) self.gpcr_aln = gpcr_aln self.myos_aln = myos_aln # a made-up dict of base frequencies to use as the natural freqs # for SCA calcs on DNA seqs self.dna_base_freqs = dict(list(zip("ACGT", [0.25] * 4))) self.rna_base_freqs = dict(list(zip("ACGU", [0.25] * 4))) self.protein_aln4 = ArrayAlignment( [("A1", "AACF"), ("A12", "AADF"), ("A123", "ADCF"), ("A111", "AAD-")], moltype=PROTEIN, ) self.rna_aln4 = ArrayAlignment( [("A1", "AAUU"), ("A12", "ACGU"), ("A123", "UUAA"), ("A111", "AAA-")], moltype=RNA, ) self.dna_aln4 = ArrayAlignment( [("A1", "AATT"), ("A12", "ACGT"), ("A123", "TTAA"), ("A111", "AAA?")], moltype=DNA, ) self.tree4 = make_tree( treestring="((A1:0.5,A111:0.5):0.5,(A12:0.5,A123:0.5):0.5);" ) def test_alignment_analyses_moltype_protein(self): """alignment methods work with moltype = PROTEIN""" r = mi_alignment(self.protein_aln4) self.assertEqual(r.shape, (4, 4)) r = nmi_alignment(self.protein_aln4) self.assertEqual(r.shape, (4, 4)) r = sca_alignment(self.protein_aln4, cutoff=0.75) self.assertEqual(r.shape, (4, 4)) r = ancestral_state_alignment(self.protein_aln4, self.tree4) self.assertEqual(r.shape, (4, 4)) def test_alignment_analyses_moltype_rna(self): """alignment methods work with moltype = RNA""" r = mi_alignment(self.rna_aln4) self.assertEqual(r.shape, (4, 4)) r = nmi_alignment(self.rna_aln4) self.assertEqual(r.shape, (4, 4)) r = sca_alignment( self.rna_aln4, cutoff=0.75, alphabet="ACGU", background_freqs=self.rna_base_freqs, ) self.assertEqual(r.shape, (4, 4)) r = ancestral_state_alignment(self.rna_aln4, self.tree4) self.assertEqual(r.shape, (4, 4)) def test_alignment_analyses_moltype_dna(self): """alignment methods work with moltype = DNA""" r = mi_alignment(self.dna_aln4) self.assertEqual(r.shape, (4, 4)) r = nmi_alignment(self.dna_aln4) self.assertEqual(r.shape, (4, 4)) r = sca_alignment( self.dna_aln4, cutoff=0.75, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) self.assertEqual(r.shape, (4, 4)) r = ancestral_state_alignment(self.dna_aln4, self.tree4) self.assertEqual(r.shape, (4, 4)) def test_join_positions(self): """join_positions functions as expected""" self.assertEqual( join_positions(list("ABCD"), list("WXYZ")), ["AW", "BX", "CY", "DZ"] ) self.assertEqual(join_positions(list("AAA"), list("BBB")), ["AB", "AB", "AB"]) self.assertEqual(join_positions([], []), []) def test_mi(self): """mi calculations function as expected with valid data""" assert_allclose(mi(1.0, 1.0, 1.0), 1.0) assert_allclose(mi(1.0, 1.0, 2.0), 0.0) assert_allclose(mi(1.0, 1.0, 1.5), 0.5) def test_normalized_mi(self): """normalized mi calculations function as expected with valid data""" assert_allclose(normalized_mi(1.0, 1.0, 1.0), 1.0) assert_allclose(normalized_mi(1.0, 1.0, 2.0), 0.0) assert_allclose(normalized_mi(1.0, 1.0, 1.5), 0.3333, 3) def test_mi_pair(self): """mi_pair calculates mi from a pair of columns""" aln = ArrayAlignment(data={"1": "AB", "2": "AB"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), 0.0) aln = ArrayAlignment(data={"1": "AB", "2": "BA"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), 1.0) # order of positions doesn't matter (when it shouldn't) aln = ArrayAlignment(data={"1": "AB", "2": "AB"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), mi_pair(aln, pos1=1, pos2=0)) aln = ArrayAlignment(data={"1": "AB", "2": "BA"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), mi_pair(aln, pos1=1, pos2=0)) def test_wrapper_functions_handle_invalid_parameters(self): """coevolve_*: functions error on missing parameters""" # missing cutoff aln = ArrayAlignment(data={"1": "AC", "2": "AC"}, moltype=PROTEIN) self.assertRaises(ValueError, coevolve_pair, sca_pair, aln, 0, 1) self.assertRaises(ValueError, coevolve_position, sca_position, aln, 0) self.assertRaises(ValueError, coevolve_alignment, sca_alignment, aln) self.assertRaises(ValueError, coevolve_alignments, sca_alignment, aln, aln) def test_coevolve_pair(self): """coevolve_pair: returns same as pair methods called directly""" aln = ArrayAlignment(data={"1": "AC", "2": "AC"}, moltype=PROTEIN) t = make_tree(treestring="(1:0.5,2:0.5);") cutoff = 0.50 # mi_pair == coevolve_pair(mi_pair,...) assert_allclose( coevolve_pair(mi_pair, aln, pos1=0, pos2=1), mi_pair(aln, pos1=0, pos2=1) ) assert_allclose( coevolve_pair(nmi_pair, aln, pos1=0, pos2=1), nmi_pair(aln, pos1=0, pos2=1) ) assert_allclose( coevolve_pair(ancestral_state_pair, aln, pos1=0, pos2=1, tree=t), ancestral_state_pair(aln, pos1=0, pos2=1, tree=t), ) assert_allclose( coevolve_pair(sca_pair, aln, pos1=0, pos2=1, cutoff=cutoff), sca_pair(aln, pos1=0, pos2=1, cutoff=cutoff), ) def test_coevolve_position(self): """coevolve_position: returns same as position methods called directly""" aln = ArrayAlignment(data={"1": "AC", "2": "AC"}, moltype=PROTEIN) t = make_tree(treestring="(1:0.5,2:0.5);") cutoff = 0.50 # mi_position == coevolve_position(mi_position,...) assert_allclose( coevolve_position(mi_position, aln, position=0), mi_position(aln, position=0), ) assert_allclose( coevolve_position(nmi_position, aln, position=0), nmi_position(aln, position=0), ) assert_allclose( coevolve_position(ancestral_state_position, aln, position=0, tree=t), ancestral_state_position(aln, position=0, tree=t), ) assert_allclose( coevolve_position(sca_position, aln, position=0, cutoff=cutoff), sca_position(aln, position=0, cutoff=cutoff), ) def test_coevolve_alignments_validation_idenifiers(self): """coevolve_alignments_validation: seq/tree validation functions""" method = sca_alignment aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) t = make_tree(treestring="(1:0.5,2:0.5);") # OK w/ no tree coevolve_alignments_validation(method, aln1, aln2, 2, None) # OK w/ tree coevolve_alignments_validation(method, aln1, aln2, 2, None, tree=t) # If there is a plus present in identifiers, we only care about the # text before the colon aln1 = ArrayAlignment(data={"1+a": "AC", "2+b": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1 + c": "EFW", "2 + d": "EGY"}, moltype=PROTEIN) t = make_tree(treestring="(1+e:0.5,2 + f:0.5);") # OK w/ no tree coevolve_alignments_validation(method, aln1, aln2, 2, None) # OK w/ tree coevolve_alignments_validation(method, aln1, aln2, 2, None, tree=t) # mismatch b/w alignments seq names aln1 = ArrayAlignment(data={"3": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) t = make_tree(treestring="(1:0.5,2:0.5);") self.assertRaises( AssertionError, coevolve_alignments_validation, method, aln1, aln2, 2, None, tree=t, ) # mismatch b/w alignments and tree seq names aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) t = make_tree(treestring="(3:0.5,2:0.5);") self.assertRaises( AssertionError, coevolve_alignments_validation, method, aln1, aln2, 2, None, tree=t, ) # mismatch b/w alignments in number of seqs aln1 = ArrayAlignment(data={"1": "AC", "2": "AD", "3": "AA"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) t = make_tree(treestring="(1:0.5,2:0.5);") self.assertRaises( AssertionError, coevolve_alignments_validation, method, aln1, aln2, 2, None ) self.assertRaises( AssertionError, coevolve_alignments_validation, method, aln1, aln2, 2, None, tree=t, ) # mismatch b/w alignments & tree in number of seqs aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) t = make_tree(treestring="(1:0.5,(2:0.5,3:0.25));") self.assertRaises( AssertionError, coevolve_alignments_validation, method, aln1, aln2, 2, None, tree=t, ) def test_coevolve_alignments_validation_min_num_seqs(self): """coevolve_alignments_validation: ValueError on fewer than min_num_seqs""" method = mi_alignment # too few sequences -> ValueError aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) coevolve_alignments_validation(method, aln1, aln2, 1, None) coevolve_alignments_validation(method, aln1, aln2, 2, None) self.assertRaises( ValueError, coevolve_alignments_validation, method, aln1, aln2, 3, None ) def test_coevolve_alignments_validation_max_num_seqs(self): """coevolve_alignments_validation: min_num_seqs <= max_num_seqs""" method = mi_alignment # min_num_seqs > max_num_seqs-> ValueError aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) coevolve_alignments_validation(method, aln1, aln2, 1, None) coevolve_alignments_validation(method, aln1, aln2, 1, 3) coevolve_alignments_validation(method, aln1, aln2, 2, 3) self.assertRaises( ValueError, coevolve_alignments_validation, method, aln1, aln2, 3, 2 ) def test_coevolve_alignments_validation_moltypes(self): """coevolve_alignments_validation: valid for acceptable moltypes""" aln1 = ArrayAlignment(data={"1": "AC", "2": "AU"}, moltype=RNA) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) # different moltype coevolve_alignments_validation(mi_alignment, aln1, aln2, 2, None) coevolve_alignments_validation(nmi_alignment, aln1, aln2, 2, None) coevolve_alignments_validation(resampled_mi_alignment, aln1, aln2, 2, None) self.assertRaises( AssertionError, coevolve_alignments_validation, sca_alignment, aln1, aln2, 2, None, ) self.assertRaises( AssertionError, coevolve_alignments_validation, ancestral_state_alignment, aln1, aln2, 2, None, ) def test_coevolve_alignments(self): """coevolve_alignments: returns correct len(aln1) x len(aln2) matrix""" aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) combined_aln = ArrayAlignment( data={"1": "ACEFW", "2": "ADEGY"}, moltype=PROTEIN ) t = make_tree(treestring="(1:0.5,2:0.5);") cutoff = 0.50 # MI m = mi_alignment(combined_aln) expected = array([[m[2, 0], m[2, 1]], [m[3, 0], m[3, 1]], [m[4, 0], m[4, 1]]]) assert_allclose(coevolve_alignments(mi_alignment, aln1, aln2), expected) # MI (return_full=True) assert_allclose( coevolve_alignments(mi_alignment, aln1, aln2, return_full=True), m ) # NMI m = nmi_alignment(combined_aln) expected = array([[m[2, 0], m[2, 1]], [m[3, 0], m[3, 1]], [m[4, 0], m[4, 1]]]) assert_allclose(coevolve_alignments(nmi_alignment, aln1, aln2), expected) # AS m = ancestral_state_alignment(combined_aln, tree=t) expected = array([[m[2, 0], m[2, 1]], [m[3, 0], m[3, 1]], [m[4, 0], m[4, 1]]]) assert_allclose( coevolve_alignments(ancestral_state_alignment, aln1, aln2, tree=t), expected ) # SCA m = sca_alignment(combined_aln, cutoff=cutoff) expected = array([[m[2, 0], m[2, 1]], [m[3, 0], m[3, 1]], [m[4, 0], m[4, 1]]]) assert_allclose( coevolve_alignments(sca_alignment, aln1, aln2, cutoff=cutoff), expected ) def test_coevolve_alignments_watches_min_num_seqs(self): """coevolve_alignments: error on too few sequences""" aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) coevolve_alignments(mi_alignment, aln1, aln2) coevolve_alignments(mi_alignment, aln1, aln2, min_num_seqs=0) coevolve_alignments(mi_alignment, aln1, aln2, min_num_seqs=1) coevolve_alignments(mi_alignment, aln1, aln2, min_num_seqs=2) self.assertRaises( ValueError, coevolve_alignments, mi_alignment, aln1, aln2, min_num_seqs=3 ) self.assertRaises( ValueError, coevolve_alignments, mi_alignment, aln1, aln2, min_num_seqs=50 ) def test_coevolve_alignments_watches_max_num_seqs(self): """coevolve_alignments: filtering or error on too many sequences""" aln1 = ArrayAlignment(data={"1": "AC", "2": "AD", "3": "YP"}, moltype=PROTEIN) aln2 = ArrayAlignment( data={"1": "ACP", "2": "EAD", "3": "PYP"}, moltype=PROTEIN ) # keep all seqs tmp_filepath = NamedTemporaryFile( prefix="tmp_test_coevolution", suffix=".fasta" ).name coevolve_alignments( mi_alignment, aln1, aln2, max_num_seqs=3, merged_aln_filepath=tmp_filepath ) self.assertEqual(load_aligned_seqs(tmp_filepath).num_seqs, 3) # keep 2 seqs coevolve_alignments( mi_alignment, aln1, aln2, max_num_seqs=2, merged_aln_filepath=tmp_filepath ) seqs = load_aligned_seqs(tmp_filepath) self.assertEqual(seqs.num_seqs, 2) # error if no sequence filter self.assertRaises( ValueError, coevolve_alignments, mi_alignment, aln1, aln2, max_num_seqs=2, merged_aln_filepath=tmp_filepath, sequence_filter=None, ) # clean up the temporary file remove(tmp_filepath) def test_coevolve_alignments_different_MolType(self): """coevolve_alignments: different MolTypes supported""" aln1 = ArrayAlignment(data={"1": "AC", "2": "AU"}, moltype=RNA) aln2 = ArrayAlignment(data={"1": "EFW", "2": "EGY"}, moltype=PROTEIN) combined_aln = ArrayAlignment(data={"1": "ACEFW", "2": "AUEGY"}) t = make_tree(treestring="(1:0.5,2:0.5);") # MI m = mi_alignment(combined_aln) expected = array([[m[2, 0], m[2, 1]], [m[3, 0], m[3, 1]], [m[4, 0], m[4, 1]]]) assert_allclose(coevolve_alignments(mi_alignment, aln1, aln2), expected) # MI (return_full=True) assert_allclose( coevolve_alignments(mi_alignment, aln1, aln2, return_full=True), m ) # NMI m = nmi_alignment(combined_aln) expected = array([[m[2, 0], m[2, 1]], [m[3, 0], m[3, 1]], [m[4, 0], m[4, 1]]]) assert_allclose(coevolve_alignments(nmi_alignment, aln1, aln2), expected) def test_mi_pair_cols_default_exclude_handling(self): """mi_pair returns null_value on excluded by default""" aln = ArrayAlignment(data={"1": "AB", "2": "-B"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), DEFAULT_NULL_VALUE) aln = ArrayAlignment(data={"1": "-B", "2": "-B"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), DEFAULT_NULL_VALUE) aln = ArrayAlignment(data={"1": "AA", "2": "-B"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), DEFAULT_NULL_VALUE) aln = ArrayAlignment(data={"1": "AA", "2": "PB"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1, excludes="P"), DEFAULT_NULL_VALUE) def test_mi_pair_cols_non_default_exclude_handling(self): """mi_pair uses non-default exclude_handler when provided""" aln = ArrayAlignment(data={"1": "A-", "2": "A-"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), DEFAULT_NULL_VALUE) assert_allclose( mi_pair(aln, pos1=0, pos2=1, exclude_handler=ignore_excludes), 0.0 ) def test_mi_pair_cols_and_entropies(self): """mi_pair calculates mi from a pair of columns and precalc entropies""" aln = ArrayAlignment(data={"1": "AB", "2": "AB"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1, h1=0.0, h2=0.0), 0.0) aln = ArrayAlignment(data={"1": "AB", "2": "BA"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1, h1=1.0, h2=1.0), 1.0) # incorrect positional entropies provided to ensure that the # precalculated values are used, and that entorpies are not # caluclated on-the-fly. aln = ArrayAlignment(data={"1": "AB", "2": "AB"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1, h1=1.0, h2=1.0), 2.0) def test_mi_pair_alt_calculator(self): """mi_pair uses alternate mi_calculator when provided""" aln = ArrayAlignment(data={"1": "AB", "2": "AB"}, moltype=PROTEIN) assert_allclose(mi_pair(aln, pos1=0, pos2=1), 0.0) assert_allclose( mi_pair(aln, pos1=0, pos2=1, mi_calculator=normalized_mi), DEFAULT_NULL_VALUE, ) def test_mi_position_valid_input(self): """mi_position functions with varied valid input""" aln = ArrayAlignment(data={"1": "ACG", "2": "GAC"}, moltype=PROTEIN) assert_allclose(mi_position(aln, 0), array([1.0, 1.0, 1.0])) aln = ArrayAlignment(data={"1": "ACG", "2": "ACG"}, moltype=PROTEIN) assert_allclose(mi_position(aln, 0), array([0.0, 0.0, 0.0])) aln = ArrayAlignment(data={"1": "ACG", "2": "ACG"}, moltype=PROTEIN) assert_allclose(mi_position(aln, 2), array([0.0, 0.0, 0.0])) def test_mi_position_from_alignment_nmi(self): """mi_position functions w/ alternate mi_calculator""" aln = ArrayAlignment(data={"1": "ACG", "2": "ACG"}, moltype=PROTEIN) assert_allclose(mi_position(aln, 0), array([0.0, 0.0, 0.0])) aln = ArrayAlignment(data={"1": "ACG", "2": "ACG"}, moltype=PROTEIN) assert_allclose( mi_position(aln, 0, mi_calculator=normalized_mi), array([DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE]), ) def test_mi_position_from_alignment_default_exclude_handling(self): """mi_position handles excludes by setting to null_value""" aln = ArrayAlignment(data={"1": "ACG", "2": "G-C"}, moltype=PROTEIN) assert_allclose(mi_position(aln, 0), array([1.0, DEFAULT_NULL_VALUE, 1.0])) aln = ArrayAlignment(data={"1": "ACG", "2": "GPC"}, moltype=PROTEIN) assert_allclose( mi_position(aln, 0, excludes="P"), array([1.0, DEFAULT_NULL_VALUE, 1.0]) ) def test_mi_position_from_alignment_non_default_exclude_handling(self): """mi_position handles excludes w/ non-default method""" aln = ArrayAlignment(data={"1": "ACG", "2": "G-C"}, moltype=PROTEIN) assert_allclose( mi_position(aln, 0, exclude_handler=ignore_excludes), array([1.0, 1.0, 1.0]) ) def test_mi_alignment_excludes(self): """mi_alignment handles excludes properly""" expected = array( [ [0.0, DEFAULT_NULL_VALUE, 0.0], [DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [0.0, DEFAULT_NULL_VALUE, 0.0], ] ) # gap in second column aln = ArrayAlignment(data={"1": "ACG", "2": "A-G"}, moltype=PROTEIN) assert_allclose(mi_alignment(aln), expected) # excludes = 'P' aln = ArrayAlignment(data={"1": "ACG", "2": "APG"}, moltype=PROTEIN) assert_allclose(mi_alignment(aln, excludes="P"), expected) # gap in first column expected = array( [ [DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [DEFAULT_NULL_VALUE, 0.0, 0.0], [DEFAULT_NULL_VALUE, 0.0, 0.0], ] ) aln = ArrayAlignment(data={"1": "-CG", "2": "ACG"}, moltype=PROTEIN) assert_allclose(mi_alignment(aln), expected) def test_mi_alignment_high(self): """mi_alignment detected perfectly correlated columns""" expected = [[1.0, 1.0], [1.0, 1.0]] aln = ArrayAlignment(data={"1": "AG", "2": "GA"}, moltype=PROTEIN) assert_allclose(mi_alignment(aln), expected) def test_mi_alignment_low(self): """mi_alignment detected in perfectly uncorrelated columns""" expected = [[0.0, 0.0], [0.0, 1.0]] aln = ArrayAlignment(data={"1": "AG", "2": "AC"}, moltype=PROTEIN) assert_allclose(mi_alignment(aln), expected) def test_resampled_mi_alignment(self): """resampled_mi_alignment returns without error""" aln = ArrayAlignment( data={"1": "ACDEF", "2": "ACFEF", "3": "ACGEF"}, moltype=PROTEIN ) resampled_mi_alignment(aln) aln = ArrayAlignment( data={"1": "ACDEF", "2": "ACF-F", "3": "ACGEF"}, moltype=PROTEIN ) resampled_mi_alignment(aln) def test_coevolve_alignment(self): """coevolve_alignment functions as expected with varied input""" aln1 = ArrayAlignment( data={"1": "ACDEF", "2": "ACFEF", "3": "ACGEF"}, moltype=PROTEIN ) # no kwargs passed assert_allclose(coevolve_alignment(mi_alignment, aln1), mi_alignment(aln1)) # different method passed assert_allclose(coevolve_alignment(nmi_alignment, aln1), nmi_alignment(aln1)) # kwargs passed assert_allclose( coevolve_alignment(mi_alignment, aln1, mi_calculator=nmi), nmi_alignment(aln1), ) def test_build_coevolution_matrix_filepath(self): """build_coevolution_matrix_filepath functions w/ varied input""" self.assertEqual(build_coevolution_matrix_filepath("./blah.fasta"), "./blah") self.assertEqual(build_coevolution_matrix_filepath("blah.fasta"), "./blah") self.assertEqual(build_coevolution_matrix_filepath("blah"), "./blah") self.assertEqual(build_coevolution_matrix_filepath("./blah"), "./blah") self.assertEqual( build_coevolution_matrix_filepath( "./blah.fasta", output_dir="./duh/", method="xx", alphabet="yyy" ), "./duh/blah.yyy.xx", ) self.assertEqual( build_coevolution_matrix_filepath( "./blah.fasta", output_dir="./duh/", method="xx", alphabet="yyy", parameter=0.25, ), "./duh/blah.yyy.xx", ) self.assertEqual( build_coevolution_matrix_filepath( "./blah.fasta", output_dir="./duh/", method="xx" ), "./duh/blah.xx", ) self.assertEqual( build_coevolution_matrix_filepath( "./blah.fasta", output_dir="./duh/", method="sca", parameter=0.25 ), "./duh/blah.sca_25", ) self.assertEqual( build_coevolution_matrix_filepath( "./blah.fasta", output_dir="./duh/", method="sca", parameter=0.25, alphabet="xx", ), "./duh/blah.xx.sca_25", ) # no trailing / to output_dir self.assertEqual( build_coevolution_matrix_filepath( "./blah.fasta", output_dir="./duh", method="sca", parameter=0.25, alphabet="xx", ), "./duh/blah.xx.sca_25", ) self.assertRaises( ValueError, build_coevolution_matrix_filepath, "./blah.fasta", "./duh/", "sca", ) self.assertRaises( ValueError, build_coevolution_matrix_filepath, "./blah.fasta", "./duh/", "sca", "xx", ) def test_pickle_coevolution_result_error(self): """pickle matrix: IOError handled correctly""" m = array([[1, 2], [3, 4]]) self.assertRaises(IOError, pickle_coevolution_result, m, "") def test_unpickle_coevolution_result_error(self): """unpickle matrix: IOError handled correctly""" self.assertRaises(IOError, unpickle_coevolution_result, "invalid/file/path.pkl") def test_pickle_and_unpickle(self): """unpickle(pickle(matrix)) == matrix""" for expected in [4.5, array([1.2, 4.3, 5.5]), array([[1.4, 2.2], [3.0, 0.4]])]: filepath = mktemp() pickle_coevolution_result(expected, filepath) actual = unpickle_coevolution_result(filepath) assert_allclose(actual, expected) remove(filepath) def test_csv_coevolution_result_error(self): """matrix -> csv: IOError handled correctly""" m = array([[1, 2], [3, 4]]) self.assertRaises(IOError, coevolution_matrix_to_csv, m, "") def test_uncsv_coevolution_result_error(self): """csv -> matrix: IOError handled correctly""" self.assertRaises(IOError, csv_to_coevolution_matrix, "invalid/file/path.pkl") def test_csv_and_uncsv(self): """converting to/from csv matrix results in correct coevolution matrix""" expected = array([[1.4, 2.2], [DEFAULT_NULL_VALUE, 0.4]]) filepath = mktemp() coevolution_matrix_to_csv(expected, filepath) actual = csv_to_coevolution_matrix(filepath) assert_allclose(actual, expected) remove(filepath) def test_parse_coevolution_matrix_filepath(self): """Parsing matrix filepaths works as expected.""" expected = ("myosin_995", "a1_4", "nmi") self.assertEqual( parse_coevolution_matrix_filepath("pkls/myosin_995.a1_4.nmi.pkl"), expected ) self.assertEqual( parse_coevolution_matrix_filepath("pkls/myosin_995.a1_4.nmi.csv"), expected ) expected = ("p53", "orig", "mi") self.assertEqual(parse_coevolution_matrix_filepath("p53.orig.mi.pkl"), expected) self.assertEqual(parse_coevolution_matrix_filepath("p53.orig.mi.csv"), expected) def test_parse_coevolution_matrix_filepath_error(self): """Parsing matrix file paths handles invalid filepaths""" self.assertRaises( ValueError, parse_coevolution_matrix_filepath, "pkls/myosin_995.nmi.pkl" ) self.assertRaises( ValueError, parse_coevolution_matrix_filepath, "pkls/myosin_995.pkl" ) self.assertRaises( ValueError, parse_coevolution_matrix_filepath, "pkls/myosin_995" ) self.assertRaises(ValueError, parse_coevolution_matrix_filepath, "") def test_identify_aln_positions_above_threshold(self): """Extracting scores above threshold works as expected""" m = array( [ [ DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE, ], [0.3, 1.0, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [0.25, 0.75, 1.0, DEFAULT_NULL_VALUE], [0.9, 0.751, 0.8, 1.0], ] ) self.assertEqual(identify_aln_positions_above_threshold(m, 0.75, 0), []) self.assertEqual(identify_aln_positions_above_threshold(m, 0.75, 1), [1]) self.assertEqual(identify_aln_positions_above_threshold(m, 0.75, 2), [1, 2]) self.assertEqual( identify_aln_positions_above_threshold(m, 0.75, 3), [0, 1, 2, 3] ) m = ltm_to_symmetric(m) self.assertEqual(identify_aln_positions_above_threshold(m, 0.75, 0), [3]) self.assertEqual(identify_aln_positions_above_threshold(m, 0.75, 1), [1, 2, 3]) self.assertEqual(identify_aln_positions_above_threshold(m, 0.75, 2), [1, 2, 3]) self.assertEqual( identify_aln_positions_above_threshold(m, 0.75, 3), [0, 1, 2, 3] ) self.assertEqual(identify_aln_positions_above_threshold(m, 1.1, 0), []) self.assertEqual(identify_aln_positions_above_threshold(m, -5.0, 0), [1, 2, 3]) self.assertEqual( identify_aln_positions_above_threshold(m, -5.0, 1), [0, 1, 2, 3] ) def test_count_ge_threshold(self): """count_ge_threshold works as expected""" m = array([[DEFAULT_NULL_VALUE] * 3] * 3) self.assertEqual(count_ge_threshold(m, 1.0), (0, 0)) self.assertEqual( count_ge_threshold(m, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE), (0, 0) ) self.assertEqual(count_ge_threshold(m, 1.0, 42), (0, 9)) m = array([[0, 1, 2], [3, 4, 5], [6, 7, 8]]) self.assertEqual(count_ge_threshold(m, 4), (5, 9)) self.assertEqual(count_ge_threshold(m, 8), (1, 9)) self.assertEqual(count_ge_threshold(m, 9), (0, 9)) m = array( [ [0, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [DEFAULT_NULL_VALUE, 4, 5], [6, 7, 8], ] ) self.assertEqual(count_ge_threshold(m, 4), (5, 6)) self.assertEqual(count_ge_threshold(m, 8), (1, 6)) self.assertEqual(count_ge_threshold(m, 9), (0, 6)) def test_count_le_threshold(self): """count_le_threshold works as expected""" m = array([[DEFAULT_NULL_VALUE] * 3] * 3) self.assertEqual(count_le_threshold(m, 1.0), (0, 0)) self.assertEqual( count_le_threshold(m, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE), (0, 0) ) self.assertEqual(count_le_threshold(m, 1.0, 42), (0, 9)) m = array([[0, 1, 2], [3, 4, 5], [6, 7, 8]]) self.assertEqual(count_le_threshold(m, 4), (5, 9)) self.assertEqual(count_le_threshold(m, 8), (9, 9)) self.assertEqual(count_le_threshold(m, 9), (9, 9)) m = array( [ [0, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [DEFAULT_NULL_VALUE, 4, 5], [6, 7, 8], ] ) self.assertEqual(count_le_threshold(m, 4), (2, 6)) self.assertEqual(count_le_threshold(m, 8), (6, 6)) self.assertEqual(count_le_threshold(m, 9), (6, 6)) def test_count_ge_threshold_symmetric_ignore_diagonal(self): """count_ge_threshold works with symmetric and/or ignoring diag = True""" # no good scores, varied null value m = array([[DEFAULT_NULL_VALUE] * 3] * 3) self.assertEqual(count_ge_threshold(m, 1.0, symmetric=True), (0, 0)) self.assertEqual(count_ge_threshold(m, 1.0, symmetric=True), (0, 0)) self.assertEqual(count_ge_threshold(m, 1.0, 42, symmetric=True), (0, 6)) self.assertEqual(count_ge_threshold(m, 1.0, ignore_diagonal=True), (0, 0)) self.assertEqual(count_ge_threshold(m, 1.0, ignore_diagonal=True), (0, 0)) self.assertEqual(count_ge_threshold(m, 1.0, 42, ignore_diagonal=True), (0, 6)) self.assertEqual( count_ge_threshold(m, 1.0, ignore_diagonal=True, symmetric=True), (0, 0) ) self.assertEqual( count_ge_threshold(m, 1.0, ignore_diagonal=True, symmetric=True), (0, 0) ) self.assertEqual( count_ge_threshold(m, 1.0, 42, ignore_diagonal=True, symmetric=True), (0, 3) ) # no null values, varied other values m = array([[0, 1, 2], [3, 4, 5], [6, 7, 8]]) self.assertEqual(count_ge_threshold(m, 4), (5, 9)) self.assertEqual(count_ge_threshold(m, 4, symmetric=True), (4, 6)) self.assertEqual(count_ge_threshold(m, 4, ignore_diagonal=True), (3, 6)) self.assertEqual( count_ge_threshold(m, 4, symmetric=True, ignore_diagonal=True), (2, 3) ) # null and mixed values m = array( [ [0, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [3, 4, DEFAULT_NULL_VALUE], [DEFAULT_NULL_VALUE, 7, 8], ] ) self.assertEqual(count_ge_threshold(m, 4), (3, 5)) self.assertEqual(count_ge_threshold(m, 4, symmetric=True), (3, 5)) self.assertEqual(count_ge_threshold(m, 4, ignore_diagonal=True), (1, 2)) self.assertEqual( count_ge_threshold(m, 4, symmetric=True, ignore_diagonal=True), (1, 2) ) def test_count_le_threshold_symmetric_ignore_diagonal(self): """count_le_threshold works with symmetric and/or ignoring diag = True""" # varied null value m = array([[DEFAULT_NULL_VALUE] * 3] * 3) self.assertEqual(count_le_threshold(m, 1.0, symmetric=True), (0, 0)) self.assertEqual(count_le_threshold(m, 1.0, symmetric=True), (0, 0)) self.assertEqual(count_le_threshold(m, 1.0, 42, symmetric=True), (0, 6)) self.assertEqual(count_le_threshold(m, 1.0, ignore_diagonal=True), (0, 0)) self.assertEqual(count_le_threshold(m, 1.0, ignore_diagonal=True), (0, 0)) self.assertEqual(count_le_threshold(m, 1.0, 42, ignore_diagonal=True), (0, 6)) self.assertEqual( count_le_threshold(m, 1.0, ignore_diagonal=True, symmetric=True), (0, 0) ) self.assertEqual( count_le_threshold(m, 1.0, ignore_diagonal=True, symmetric=True), (0, 0) ) self.assertEqual( count_le_threshold(m, 1.0, 42, ignore_diagonal=True, symmetric=True), (0, 3) ) # no null values, varied other values m = array([[0, 1, 2], [3, 4, 5], [6, 7, 8]]) self.assertEqual(count_le_threshold(m, 4), (5, 9)) self.assertEqual(count_le_threshold(m, 4, symmetric=True), (3, 6)) self.assertEqual(count_le_threshold(m, 4, ignore_diagonal=True), (3, 6)) self.assertEqual( count_le_threshold(m, 4, symmetric=True, ignore_diagonal=True), (1, 3) ) # null and mixed values m = array( [ [0, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [3, 4, DEFAULT_NULL_VALUE], [DEFAULT_NULL_VALUE, 7, 8], ] ) self.assertEqual(count_le_threshold(m, 4), (3, 5)) self.assertEqual(count_le_threshold(m, 4, symmetric=True), (3, 5)) self.assertEqual(count_le_threshold(m, 4, ignore_diagonal=True), (1, 2)) self.assertEqual( count_le_threshold(m, 4, symmetric=True, ignore_diagonal=True), (1, 2) ) def test_aln_position_pairs_cmp_threshold_intramolecular(self): """aln_position_pairs_ge_threshold: intramolecular matrix""" m = array( [ [0, DEFAULT_NULL_VALUE, DEFAULT_NULL_VALUE], [3, 4, DEFAULT_NULL_VALUE], [DEFAULT_NULL_VALUE, 7, 8], ] ) # cmp_function = ge self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, greater_equal), [(1, 1), (2, 1), (2, 2)], ) # cmp_function = greater_equal, alt null_value self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, greater_equal, null_value=4), [(2, 1), (2, 2)], ) # cmp_function = le self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, less_equal), [(0, 0), (1, 0)] ) # results equal results with wrapper functions self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, greater_equal), aln_position_pairs_ge_threshold(m, 3.5), ) self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, less_equal), aln_position_pairs_le_threshold(m, 3.5), ) self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, greater_equal, null_value=4), aln_position_pairs_ge_threshold(m, 3.5, null_value=4), ) self.assertEqual( aln_position_pairs_cmp_threshold(m, 3.5, less_equal, null_value=0), aln_position_pairs_le_threshold(m, 3.5, null_value=0), ) def test_aln_position_pairs_ge_threshold_intermolecular(self): """aln_position_pairs_ge_threshold: intermolecular matrix""" m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) # error if failed to specify intermolecular_data_only=True self.assertRaises( AssertionError, aln_position_pairs_cmp_threshold, m, 3.5, greater_equal ) # cmp_function = ge self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, greater_equal, intermolecular_data_only=True ), [(1, 4), (2, 4), (0, 5), (1, 5), (2, 5), (3, 5)], ) # cmp_function = greater_equal, alt null_value self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, greater_equal, null_value=18.0, intermolecular_data_only=True ), [(1, 4), (2, 4), (0, 5), (2, 5), (3, 5)], ) # cmp_function = le self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, less_equal, intermolecular_data_only=True ), [(0, 4), (3, 4)], ) # results equal results with wrapper functions self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, greater_equal, intermolecular_data_only=True ), aln_position_pairs_ge_threshold(m, 3.5, intermolecular_data_only=True), ) self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, less_equal, intermolecular_data_only=True ), aln_position_pairs_le_threshold(m, 3.5, intermolecular_data_only=True), ) self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, greater_equal, null_value=4.0, intermolecular_data_only=True ), aln_position_pairs_ge_threshold( m, 3.5, null_value=4.0, intermolecular_data_only=True ), ) self.assertEqual( aln_position_pairs_cmp_threshold( m, 3.5, less_equal, null_value=18.0, intermolecular_data_only=True ), aln_position_pairs_le_threshold( m, 3.5, null_value=18.0, intermolecular_data_only=True ), ) def test_is_parsimony_informative_strict(self): """is_parsimony_informative functions as expected with strict=True""" freqs = {"A": 25} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 25, "-": 25} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 25, "?": 25} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 25, "B": 1} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 1, "B": 1, "C": 1, "D": 1, "E": 1} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 2, "B": 1, "C": 1, "D": 1, "E": 1} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 2, "B": 2, "C": 1, "D": 1, "E": 1} self.assertFalse(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 25, "B": 2} self.assertTrue(is_parsimony_informative(freqs, strict=True)) freqs = {"A": 2, "B": 2, "C": 2, "D": 2, "E": 2} self.assertTrue(is_parsimony_informative(freqs, strict=True)) def test_is_parsimony_informative_non_strict(self): """is_parsimony_informative functions as expected with strict=False""" freqs = {"A": 25} self.assertFalse(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 25, "-": 25} self.assertFalse(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 25, "?": 25} self.assertFalse(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 25, "B": 1} self.assertFalse(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 1, "B": 1, "C": 1, "D": 1, "E": 1} self.assertFalse(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 2, "B": 1, "C": 1, "D": 1, "E": 1} self.assertFalse(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 2, "B": 2, "C": 1, "D": 1, "E": 1} self.assertTrue(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 25, "B": 2} self.assertTrue(is_parsimony_informative(freqs, strict=False)) freqs = {"A": 2, "B": 2, "C": 2, "D": 2, "E": 2} self.assertTrue(is_parsimony_informative(freqs, strict=False)) def test_is_parsimony_informative_non_default(self): """is_parsimony_informative functions w non default paramters""" # NEED TO UPDATE THESE TESTS BASED ON MY ERROR IN THE # DEFINITION OF PARSIMONY INFORMATIVE. # changed minimum_count freqs = {"A": 25, "B": 2} self.assertFalse(is_parsimony_informative(freqs, minimum_count=3, strict=False)) freqs = {"A": 25, "B": 1} self.assertTrue(is_parsimony_informative(freqs, minimum_count=1, strict=False)) # different value of strict yields different results freqs = {"A": 25, "B": 2, "C": 3} self.assertTrue(is_parsimony_informative(freqs, minimum_count=3, strict=False)) self.assertFalse(is_parsimony_informative(freqs, minimum_count=3, strict=True)) # changed minimum_differences freqs = {"A": 25, "B": 25} self.assertFalse( is_parsimony_informative(freqs, minimum_differences=3, strict=False) ) freqs = {"A": 25} self.assertTrue( is_parsimony_informative(freqs, minimum_differences=1, strict=False) ) # changed ignored freqs = {"A": 25, "-": 25, "?": 25} self.assertTrue(is_parsimony_informative(freqs, ignored=None, strict=False)) freqs = {"A": 25, "?": 25} self.assertTrue(is_parsimony_informative(freqs, ignored="", strict=False)) freqs = {"A": 25, "-": 25} self.assertTrue(is_parsimony_informative(freqs, ignored=None, strict=False)) freqs = {"A": 25, "C": 25} self.assertFalse(is_parsimony_informative(freqs, ignored="A", strict=False)) def test_filter_non_parsimony_informative_intramolecular(self): """non-parsimony informative sites in intramolecular matrix -> null""" aln = make_aligned_seqs( data={"1": "ACDE", "2": "ACDE", "3": "ACDE", "4": "ACDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array([[DEFAULT_NULL_VALUE] * 4] * 4) filter_non_parsimony_informative(aln, m) assert_allclose(m, expected) aln = make_aligned_seqs( data={"1": "ACDE", "2": "FCDE", "3": "ACDE", "4": "FCDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [42.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array([[DEFAULT_NULL_VALUE] * 4] * 4) expected[0, 0] = 42.0 filter_non_parsimony_informative(aln, m) assert_allclose(m, expected) def test_filter_non_parsimony_informative_intermolecular(self): """non-parsimony informative sites in intermolecular matrix -> null""" # all non-parsimony informative aln = make_aligned_seqs( data={"1": "ACDEWQ", "2": "ACDEWQ", "3": "ACDEWQ", "4": "ACDEWQ"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array([[DEFAULT_NULL_VALUE] * 4] * 2) filter_non_parsimony_informative(aln, m, intermolecular_data_only=True) assert_allclose(m, expected) # one non-parsimony informative pair of positions aln = make_aligned_seqs( data={"1": "FCDEWD", "2": "ACDEWQ", "3": "ACDEWD", "4": "FCDEWQ"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array([[DEFAULT_NULL_VALUE] * 4] * 2) expected[1, 0] = 9.0 filter_non_parsimony_informative(aln, m, intermolecular_data_only=True) assert_allclose(m, expected) # all parsimony informative aln = make_aligned_seqs( data={"1": "FFFFFF", "2": "FFFFFF", "3": "GGGGGG", "4": "GGGGGG"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) filter_non_parsimony_informative(aln, m, intermolecular_data_only=True) assert_allclose(m, expected) def test_filter_exclude_positions_intramolecular(self): """filter_exclude_positions: functions for intramolecular data""" # filter zero positions (no excludes) aln = make_aligned_seqs( data={"1": "WCDE", "2": "ACDE", "3": "ACDE", "4": "ACDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m) assert_allclose(m, expected) # filter zero positions (max_exclude_percentage = percent exclude) aln = make_aligned_seqs( data={"1": "-CDE", "2": "A-DE", "3": "AC-E", "4": "ACD-"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m, max_exclude_percent=0.25) assert_allclose(m, expected) # filter zero positions (max_exclude_percentage too high) aln = make_aligned_seqs( data={"1": "-CDE", "2": "A-DE", "3": "AC-E", "4": "ACD-"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m, max_exclude_percent=0.5) assert_allclose(m, expected) # filter one position (defualt max_exclude_percentage) aln = make_aligned_seqs( data={"1": "-CDE", "2": "ACDE", "3": "ACDE", "4": "ACDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [DEFAULT_NULL_VALUE] * 4, [DEFAULT_NULL_VALUE, 18.0, 5.0, 6.0], [DEFAULT_NULL_VALUE, 1.0, 3.0, 2.0], [DEFAULT_NULL_VALUE, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m) assert_allclose(m, expected) # filter one position (non-defualt max_exclude_percentage) aln = make_aligned_seqs( data={"1": "-CDE", "2": "ACDE", "3": "ACDE", "4": "-CDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [DEFAULT_NULL_VALUE] * 4, [DEFAULT_NULL_VALUE, 18.0, 5.0, 6.0], [DEFAULT_NULL_VALUE, 1.0, 3.0, 2.0], [DEFAULT_NULL_VALUE, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m, max_exclude_percent=0.49) assert_allclose(m, expected) # filter all positions (defualt max_exclude_percentage) aln = make_aligned_seqs( data={"1": "----", "2": "ACDE", "3": "ACDE", "4": "ACDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array([[DEFAULT_NULL_VALUE] * 4] * 4) filter_exclude_positions(aln, m) assert_allclose(m, expected) # filter all positions (non-defualt max_exclude_percentage) aln = make_aligned_seqs( data={"1": "----", "2": "A-DE", "3": "AC--", "4": "-CDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 3.0], ] ) expected = array([[DEFAULT_NULL_VALUE] * 4] * 4) filter_exclude_positions(aln, m, max_exclude_percent=0.49) assert_allclose(m, expected) # filter one position (defualt max_exclude_percentage, # non-defualt excludes) aln = make_aligned_seqs( data={"1": "WCDE", "2": "ACDE", "3": "ACDE", "4": "ACDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [DEFAULT_NULL_VALUE] * 4, [DEFAULT_NULL_VALUE, 18.0, 5.0, 6.0], [DEFAULT_NULL_VALUE, 1.0, 3.0, 2.0], [DEFAULT_NULL_VALUE, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m, excludes="W") assert_allclose(m, expected) # filter one position (defualt max_exclude_percentage, # non-defualt null_value) aln = make_aligned_seqs( data={"1": "-CDE", "2": "ACDE", "3": "ACDE", "4": "ACDE"}, moltype=PROTEIN, array_align=True, ) m = array( [ [1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0], [4.0, 1.0, 3.0, 2.0], [21.0, 0.0, 1.0, 33.0], ] ) expected = array( [ [999.0] * 4, [999.0, 18.0, 5.0, 6.0], [999.0, 1.0, 3.0, 2.0], [999.0, 0.0, 1.0, 33.0], ] ) filter_exclude_positions(aln, m, null_value=999.0) assert_allclose(m, expected) def test_filter_exclude_positions_intermolecular(self): """filter_exclude_positions: functions for intermolecular data""" # these tests correspond to alignments of length 4 and 2 positions # respectively, hence a coevolution_matrix with shape = (2,4) # filter zero positions (no excludes) merged_aln = make_aligned_seqs( data={"1": "WCDEDE", "2": "ACDEDE", "3": "ACDEDE", "4": "ACDEDE"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) filter_exclude_positions(merged_aln, m, intermolecular_data_only=True) assert_allclose(m, expected) # filter one position (aln1) merged_aln = make_aligned_seqs( data={"1": "WC-EDE", "2": "ACDEDE", "3": "ACDEDE", "4": "ACDEDE"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array( [[1.0, 10.0, DEFAULT_NULL_VALUE, 3.0], [9.0, 18.0, DEFAULT_NULL_VALUE, 6.0]] ) filter_exclude_positions(merged_aln, m, intermolecular_data_only=True) assert_allclose(m, expected) # filter one position (aln2) merged_aln = make_aligned_seqs( data={"1": "WCEEDE", "2": "ACDEDE", "3": "ACDEDE", "4": "ACDED-"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array([[1.0, 10.0, 4.0, 3.0], [DEFAULT_NULL_VALUE] * 4]) filter_exclude_positions(merged_aln, m, intermolecular_data_only=True) assert_allclose(m, expected) # filter two positions (aln1 & aln2) merged_aln = make_aligned_seqs( data={"1": "-CEEDE", "2": "ACDEDE", "3": "ACDEDE", "4": "ACDED-"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array( [[DEFAULT_NULL_VALUE, 10.0, 4.0, 3.0], [DEFAULT_NULL_VALUE] * 4] ) filter_exclude_positions(merged_aln, m, intermolecular_data_only=True) assert_allclose(m, expected) # filter two positions (aln1 & aln2, alt excludes) merged_aln = make_aligned_seqs( data={"1": "WCEEDE", "2": "ACDEDE", "3": "ACDEDE", "4": "ACDEDW"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array( [[DEFAULT_NULL_VALUE, 10.0, 4.0, 3.0], [DEFAULT_NULL_VALUE] * 4] ) filter_exclude_positions( merged_aln, m, intermolecular_data_only=True, excludes="W" ) assert_allclose(m, expected) # filter two positions (aln1 & aln2, alt null_value) merged_aln = make_aligned_seqs( data={"1": "-CEEDE", "2": "ACDEDE", "3": "ACDEDE", "4": "ACDED-"}, moltype=PROTEIN, array_align=True, ) m = array([[1.0, 10.0, 4.0, 3.0], [9.0, 18.0, 5.0, 6.0]]) expected = array([[999.0, 10.0, 4.0, 3.0], [999.0] * 4]) filter_exclude_positions( merged_aln, m, intermolecular_data_only=True, null_value=999.0 ) assert_allclose(m, expected) def test_filter_threshold_based_multiple_interdependency_intermolecular(self): "multiple interdependency filter functions with intermolecular data" ## cmp_function = ge # lower boundary null = DEFAULT_NULL_VALUE m = array( [ [0.63, 0.00, null], [0.75, 0.10, 0.45], [0.95, 0.32, 0.33], [1.00, 0.95, 0.11], ] ) expected = array( [ [null, null, null], [null, null, 0.45], [null, null, null], [null, null, null], ] ) actual = filter_threshold_based_multiple_interdependency( None, m, 0.95, 0, greater_equal, True ) assert_allclose(actual, expected) # realisitic test case m = array( [ [0.63, 0.00, null], [0.75, 0.10, 0.45], [0.95, 0.32, 0.33], [1.00, 0.95, 0.11], ] ) expected = array( [ [null, 0.00, null], [null, 0.10, 0.45], [null, 0.32, 0.33], [null, null, null], ] ) actual = filter_threshold_based_multiple_interdependency( None, m, 0.95, 1, greater_equal, True ) assert_allclose(actual, expected) # upper boundary, nothing filtered null = DEFAULT_NULL_VALUE m = array( [ [0.63, 0.00, null], [0.75, 0.10, 0.45], [0.95, 0.32, 0.33], [1.00, 0.95, 0.11], ] ) expected = m actual = filter_threshold_based_multiple_interdependency( None, m, 0.95, 5, greater_equal, True ) assert_allclose(actual, expected) # cmp_function = less_equal, realistic test case m = array( [ [0.63, 0.00, null], [0.75, 0.10, 0.45], [0.95, 0.32, 0.33], [1.00, 0.95, 0.11], ] ) expected = array( [ [0.63, null, null], [0.75, null, null], [null, null, null], [1.00, null, null], ] ) actual = filter_threshold_based_multiple_interdependency( None, m, 0.35, 1, less_equal, True ) assert_allclose(actual, expected) def test_filter_threshold_based_multiple_interdependency_intramolecular(self): "multiple interdependency filter functions with intramolecular data" null = DEFAULT_NULL_VALUE ## cmp_function = ge # lower bound, everything filtered m = array( [ [0.63, 0.75, 0.95, 1.00], [0.75, 0.10, null, 0.95], [0.95, null, 0.33, 0.11], [1.00, 0.95, 0.11, 1.00], ] ) expected = array( [ [null, null, null, null], [null, null, null, null], [null, null, null, null], [null, null, null, null], ] ) actual = filter_threshold_based_multiple_interdependency( None, m, 0.95, 0, greater_equal ) assert_allclose(actual, expected) # realistic test case m = array( [ [0.63, 0.75, 0.95, 1.00], [0.75, 0.10, null, 0.95], [0.95, null, 0.33, 0.11], [1.00, 0.95, 0.11, 1.00], ] ) expected = array( [ [null, null, null, null], [null, 0.10, null, null], [null, null, 0.33, null], [null, null, null, null], ] ) actual = filter_threshold_based_multiple_interdependency( None, m, 0.95, 1, greater_equal ) assert_allclose(actual, expected) # upper boundary, nothing filtered m = array( [ [0.63, 0.75, 0.95, 1.00], [0.75, 0.10, null, 0.95], [0.95, null, 0.33, 0.11], [1.00, 0.95, 0.11, 1.00], ] ) expected = m actual = filter_threshold_based_multiple_interdependency( None, m, 0.95, 5, greater_equal ) assert_allclose(actual, expected) ## cmp_function = le # realistic test case m = array( [ [0.63, 0.75, 0.95, 1.00], [0.75, 0.10, null, 0.95], [0.95, null, 0.33, 0.11], [1.00, 0.95, 0.11, 1.00], ] ) expected = array( [ [0.63, 0.75, null, 1.00], [0.75, 0.10, null, 0.95], [null, null, null, null], [1.00, 0.95, null, 1.00], ] ) actual = filter_threshold_based_multiple_interdependency( None, m, 0.33, 1, less_equal ) assert_allclose(actual, expected) def test_probs_from_dict(self): """probs_from_dict: dict of probs -> list of probs in alphabet's order""" d = {"A": 0.25, "D": 0.52, "C": 0.23} a = list("ACD") assert_allclose(probs_from_dict(d, a), [0.25, 0.23, 0.52]) a = list("ADC") assert_allclose(probs_from_dict(d, a), [0.25, 0.52, 0.23]) a = list("DCA") assert_allclose(probs_from_dict(d, a), [0.52, 0.23, 0.25]) a = CharAlphabet("DCA") assert_allclose(probs_from_dict(d, a), [0.52, 0.23, 0.25]) # protein natural probs l = probs_from_dict(protein_dict, AAGapless) for i in range(20): assert_allclose(l[i], protein_dict[AAGapless[i]], 0.001) def test_freqs_from_aln(self): """freqs_from_aln: freqs of alphabet chars in aln is calc'ed correctly""" # non-default scaled_aln_size aln = ArrayAlignment( data=list(zip(list(range(4)), ["ACGT", "AGCT", "ACCC", "TAGG"])), moltype=PROTEIN, ) alphabet = "ACGT" expected = [4, 5, 4, 3] assert_equal(freqs_from_aln(aln, alphabet, 16), expected) # change the order of the alphabet alphabet = "TGCA" expected = [3, 4, 5, 4] assert_equal(freqs_from_aln(aln, alphabet, 16), expected) # default scaled_aln_size, sums of freqs == 100 alphabet = "ACGT" expected = [25.0, 31.25, 25, 18.75] assert_allclose(freqs_from_aln(aln, alphabet), expected) # alphabet char which doesn't show up gets zero freq alphabet = "ACGTW" expected = [25.0, 31.25, 25, 18.75, 0] assert_allclose(freqs_from_aln(aln, alphabet), expected) # alignment char which doesn't show up is silently ignored aln = ArrayAlignment( data=list(zip(list(range(4)), ["ACGT", "AGCT", "ACCC", "TWGG"])), moltype=PROTEIN, ) alphabet = "ACGT" expected = [18.75, 31.25, 25, 18.75] assert_allclose(freqs_from_aln(aln, alphabet), expected) def test_freqs_to_array(self): """freqs_to_array: should convert CategoryCounter object to array""" # should work with empty object f = CategoryCounter() f2a = freqs_to_array assert_allclose(f2a(f, AAGapless), zeros(20)) # should work with full object, omitting unwanted keys f = CategoryCounter({"A": 20, "Q": 30, "X": 20}) expected = zeros(20) expected[AAGapless.index("A")] = 20 expected[AAGapless.index("Q")] = 30 assert_allclose(f2a(f, AAGapless), expected) # should work for normal dict and any alphabet d = {"A": 3, "D": 1, "C": 5, "E": 2} alpha = "ABCD" exp = array([3, 0, 5, 1]) assert_allclose(f2a(d, alpha), exp) def test_get_allowed_perturbations(self): """get_allowed_perturbations: should work for different cutoff values""" counts = [50, 40, 10, 0] a = list("ACGT") self.assertEqual(get_allowed_perturbations(counts, 1.0, a), []) self.assertEqual(get_allowed_perturbations(counts, 0.51, a), []) self.assertEqual(get_allowed_perturbations(counts, 0.5, a), ["A"]) self.assertEqual(get_allowed_perturbations(counts, 0.49, a), ["A"]) self.assertEqual(get_allowed_perturbations(counts, 0.401, a), ["A"]) self.assertEqual(get_allowed_perturbations(counts, 0.40, a), ["A", "C"]) self.assertEqual(get_allowed_perturbations(counts, 0.399, a), ["A", "C"]) self.assertEqual(get_allowed_perturbations(counts, 0.10, a), ["A", "C", "G"]) self.assertEqual(get_allowed_perturbations(counts, 0.0, a), a) def test_get_subalignments(self): """get_subalignments: works with different alignment sizes and cutoffs""" aln = ArrayAlignment( data={1: "AAAA", 2: "AAAC", 3: "AACG", 4: "ACCT", 5: "ACG-"}, moltype=PROTEIN, ) sub_aln_0A = ArrayAlignment( data={1: "AAAA", 2: "AAAC", 3: "AACG", 4: "ACCT", 5: "ACG-"}, moltype=PROTEIN, ) sub_aln_1A = ArrayAlignment( data={1: "AAAA", 2: "AAAC", 3: "AACG"}, moltype=PROTEIN ) sub_aln_1C = ArrayAlignment(data={4: "ACCT", 5: "ACG-"}, moltype=PROTEIN) sub_aln_2G = ArrayAlignment(data={5: "ACG-"}, moltype=PROTEIN) self.assertEqual(get_subalignments(aln, 0, ["A"]), [sub_aln_0A]) self.assertEqual(get_subalignments(aln, 0, ["C"]), []) self.assertEqual(get_subalignments(aln, 1, ["A"]), [sub_aln_1A]) self.assertEqual(get_subalignments(aln, 1, ["C"]), [sub_aln_1C]) self.assertEqual( get_subalignments(aln, 1, ["A", "C"]), [sub_aln_1A, sub_aln_1C] ) self.assertEqual(get_subalignments(aln, 2, ["G"]), [sub_aln_2G]) self.assertEqual(get_subalignments(aln, 3, ["-"]), [sub_aln_2G]) def test_get_positional_frequencies_w_scale(self): """get_positional_frequencies: works with default scaled_aln_size""" aln = ArrayAlignment( data={1: "ACDE", 2: "ADDE", 3: "AEED", 4: "AFEF"}, moltype=PROTEIN ) expected_0 = array([100.0, 0.0, 0.0, 0.0, 0.0]) expected_1 = array([0.0, 25.0, 25.0, 25.0, 25.0]) expected_2 = array([0.0, 0.0, 50.0, 50.0, 0.0]) expected_3 = array([0.0, 0.0, 25.0, 50.0, 25.0]) assert_allclose(get_positional_frequencies(aln, 0, "ACDEF"), expected_0) assert_allclose(get_positional_frequencies(aln, 1, "ACDEF"), expected_1) assert_allclose(get_positional_frequencies(aln, 2, "ACDEF"), expected_2) assert_allclose(get_positional_frequencies(aln, 3, "ACDEF"), expected_3) # extra characters (W) are silently ignored -- is this the desired # behavior? aln = ArrayAlignment( data={1: "WCDE", 2: "ADDE", 3: "AEED", 4: "AFEF"}, moltype=PROTEIN ) expected_0 = array([75.0, 0.0, 0.0, 0.0, 0.0]) assert_allclose(get_positional_frequencies(aln, 0, "ACDEF"), expected_0) # 20 residue amino acid alphabet aln = ArrayAlignment( data={1: "ACDE", 2: "ADDE", 3: "AEED", 4: "AFEF"}, moltype=PROTEIN ) expected = array([100.0] + [0.0] * 19) assert_allclose(get_positional_frequencies(aln, 0, AAGapless), expected) def test_get_positional_frequencies(self): """get_positional_frequencies: works with non-default scaled_aln_size""" aln = ArrayAlignment( data={1: "ACDE", 2: "ADDE", 3: "AEED", 4: "AFEF"}, moltype=PROTEIN ) expected_0 = array([4.0, 0.0, 0.0, 0.0, 0.0]) expected_1 = array([0.0, 1.0, 1.0, 1.0, 1.0]) expected_2 = array([0.0, 0.0, 2.0, 2.0, 0.0]) expected_3 = array([0.0, 0.0, 1.0, 2.0, 1.0]) assert_allclose(get_positional_frequencies(aln, 0, "ACDEF", 4), expected_0) assert_allclose(get_positional_frequencies(aln, 1, "ACDEF", 4), expected_1) assert_allclose(get_positional_frequencies(aln, 2, "ACDEF", 4), expected_2) assert_allclose(get_positional_frequencies(aln, 3, "ACDEF", 4), expected_3) # extra characters (W) are silently ignored -- is this the desired # behavior? aln = ArrayAlignment( data={1: "WCDE", 2: "ADDE", 3: "AEED", 4: "AFEF"}, moltype=PROTEIN ) expected_0 = array([3.0, 0.0, 0.0, 0.0, 0.0]) assert_allclose(get_positional_frequencies(aln, 0, "ACDEF", 4), expected_0) # 20 residue amino acid alphabet aln = ArrayAlignment( data={1: "ACDE", 2: "ADDE", 3: "AEED", 4: "AFEF"}, moltype=PROTEIN ) expected = array([4.0] + [0.0] * 19) assert_allclose(get_positional_frequencies(aln, 0, AAGapless, 4), expected) def test_validate_alphabet_invalid(self): """validate_alphabet: raises error on incompatible alpabet and freqs""" # len(alpha) > len(freqs) self.assertRaises(ValueError, validate_alphabet, "ABC", {"A": 0.5, "B": 0.5}) self.assertRaises(ValueError, validate_alphabet, "ABCD", {"A": 0.5, "B": 0.5}) # len(alpha) == len(freqs) self.assertRaises(ValueError, validate_alphabet, "AC", {"A": 0.5, "B": 0.5}) # len(alpha) < len(freqs) self.assertRaises(ValueError, validate_alphabet, "A", {"A": 0.5, "B": 0.5}) self.assertRaises(ValueError, validate_alphabet, "", {"A": 0.5, "B": 0.5}) # different values, len(alpha) > len(freqs) self.assertRaises(ValueError, validate_alphabet, [1, 42, 3], {42: 0.5, 1: 0.5}) self.assertRaises( ValueError, validate_alphabet, CharAlphabet("ABC"), {"A": 0.5, "C": 0.5} ) def test_validate_alphabet_valid(self): """validate_alphabet: does nothing on compatible alpabet and freqs""" validate_alphabet("AB", {"A": 0.5, "B": 0.5}) validate_alphabet(CharAlphabet("AB"), {"A": 0.5, "B": 0.5}) validate_alphabet([1, 42, 8], {1: 0.5, 42: 0.25, 8: 0.25}) def test_validate_position_invalid(self): """validate_position: raises error on invalid position""" self.assertRaises(ValueError, validate_position, self.dna_aln, 4) self.assertRaises(ValueError, validate_position, self.dna_aln, 42) self.assertRaises(ValueError, validate_position, self.dna_aln, -1) self.assertRaises(ValueError, validate_position, self.dna_aln, -199) def test_validate_position_valid(self): """validate_position: does nothing on valid position""" validate_position(self.dna_aln, 0) validate_position(self.dna_aln, 1) validate_position(self.dna_aln, 2) validate_position(self.dna_aln, 3) def test_validate_alignment(self): """validate_alignment: ValueError on bad alignment characters""" # ambiguous characters aln = ArrayAlignment( data={0: "BA", 1: "AC", 2: "CG", 3: "CT", 4: "TA"}, moltype=PROTEIN ) self.assertRaises(ValueError, validate_alignment, aln) aln = ArrayAlignment( data={0: "NA", 1: "AC", 2: "CG", 3: "CT", 4: "TA"}, moltype=DNA ) self.assertRaises(ValueError, validate_alignment, aln) aln = ArrayAlignment( data={0: "YA", 1: "AC", 2: "CG", 3: "CU", 4: "UA"}, moltype=RNA ) self.assertRaises(ValueError, validate_alignment, aln) aln = ArrayAlignment( data={0: "AA", 1: "AC", 2: "CG", 3: "CT", 4: "TA"}, moltype=PROTEIN ) validate_alignment(aln) aln = ArrayAlignment( data={0: "AA", 1: "AC", 2: "CG", 3: "CT", 4: "TA"}, moltype=DNA ) validate_alignment(aln) aln = ArrayAlignment( data={0: "AA", 1: "AC", 2: "CG", 3: "CU", 4: "UA"}, moltype=RNA ) validate_alignment(aln) def test_coevolve_functions_validate_alignment(self): """coevolve_*: functions run validate alignment""" aln = ArrayAlignment( data={"0": "BA", "1": "AC", "2": "CG", "3": "CT", "4": "TA"}, moltype=PROTEIN, ) self.assertRaises(ValueError, coevolve_pair, mi_pair, aln, 0, 1) self.assertRaises(ValueError, coevolve_position, mi_position, aln, 0) self.assertRaises(ValueError, coevolve_alignment, mi_alignment, aln) self.assertRaises(ValueError, coevolve_alignments, mi_alignment, aln, aln) def test_get_positional_probabilities_w_non_def_num_seqs(self): """get_positional_probabilities: works w/ non-def num_seqs""" freqs = [1.0, 2.0, 0.0] probs = [0.33, 0.33, 0.33] expected = array([0.444411, 0.218889, 0.300763]) assert_allclose(get_positional_probabilities(freqs, probs, 3), expected) def test_get_dg(self): """get_dg: returns delta_g vector""" p = [0.1, 0.2, 0.3] a = [0.5, 0.6, 0.7] expected = [log(0.1 / 0.5), log(0.2 / 0.6), log(0.3 / 0.7)] assert_allclose(get_dg(p, a), expected) def test_get_dgg(self): """get_dgg: returns delta_delta_g value given two delta_g vectors""" v1 = array([0.05, 0.5, 0.1]) v2 = array([0.03, 0.05, 0.1]) expected = sqrt(sum((v1 - v2) * (v1 - v2))) / 100 * e assert_allclose(get_dgg(v1, v2), expected) def test_get_positional_probabilities_w_def_num_seqs(self): """get_positional_probabilities: works w/ num_seqs scaled to 100 (def)""" freqs = [15.0, 33.0, 52.0] probs = [0.33, 0.33, 0.33] expected = array([2.4990e-5, 0.0846, 3.8350e-5]) assert_allclose(get_positional_probabilities(freqs, probs), expected, 0.001) def test_get_positional_probs_handles_rounding_error_in_freqs(self): """get_positional_probabilities: works w/ rounding error in freqs""" # Since freqs are scaled to scaled_aln_size, rounding error can cause # errors for positions that are perfectly controled. Testing here that # that value error is handled. # default scaled_aln_size freqs = [100.0000000001, 0.0, 0.0] probs = [0.33, 0.33, 0.33] expected = array([7.102218e-49, 4.05024e-18, 4.05024e-18]) assert_allclose(get_positional_probabilities(freqs, probs), expected, rtol=1e-5) # value that is truely over raises an error freqs = [101.0000000001, 0.0, 0.0] probs = [0.33, 0.33, 0.33] self.assertRaises(ValueError, get_positional_probabilities, freqs, probs) # non-default scaled_aln_size freqs = [50.0000000001, 0.0, 0.0] probs = [0.33, 0.33, 0.33] expected = array([8.42747e-25, 2.01252e-9, 2.01252e-9]) assert_allclose( get_positional_probabilities(freqs, probs, 50), expected, rtol=1e-5 ) # value that is truely over raises an error freqs = [51.0000000001, 0.0, 0.0] probs = [0.33, 0.33, 0.33] self.assertRaises(ValueError, get_positional_probabilities, freqs, probs, 50) def test_sca_input_validation(self): """sca_input_validation: handles sca-specific validation steps""" # moltype != PROTEIN makes background freqs required self.assertRaises(ValueError, sca_input_validation, self.dna_aln, cutoff=0.4) self.assertRaises(ValueError, sca_input_validation, self.rna_aln, cutoff=0.4) # no cutoff -> ValueError self.assertRaises(ValueError, sca_input_validation, self.protein_aln) # low cutoff -> ValueError self.assertRaises( ValueError, sca_input_validation, self.protein_aln, cutoff=-0.001 ) # high cutoff -> ValueError self.assertRaises( ValueError, sca_input_validation, self.protein_aln, cutoff=1.001 ) # good cut-off -> no error sca_input_validation(self.protein_aln, cutoff=0.50) sca_input_validation(self.protein_aln, cutoff=0.0) sca_input_validation(self.protein_aln, cutoff=1.0) # only bad alphabet -> ValueError self.assertRaises( ValueError, sca_input_validation, self.dna_aln, cutoff=0.5, alphabet="ABC" ) # only bad background_freqs -> ValueError self.assertRaises( ValueError, sca_input_validation, self.dna_aln, cutoff=0.5, background_freqs={"A": 0.25, "C": 0.75}, ) # incompatible background_freqs & alphabet provided -> ValueError self.assertRaises( ValueError, sca_input_validation, self.dna_aln, cutoff=0.5, alphabet="ABC", background_freqs={"A": 0.25, "C": 0.75}, ) # default alphabet, background_freqs -> no error sca_input_validation(self.protein_aln, cutoff=0.50) # compatible non-default alphabet, backgorund_freqs -> no error sca_input_validation( self.dna_aln, cutoff=0.50, alphabet="A", background_freqs={"A": 1.0} ) # Note: don't need a full set of tests of validate_alphabet here -- # it's tested on it's own. def test_sca_pair_no_error(self): """sca_pair: returns w/o error""" r = sca_pair( self.dna_aln, 1, 0, cutoff=0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) r = coevolve_pair( sca_pair, self.dna_aln, 1, 0, cutoff=0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) def test_sca_pair_return_all(self): """sca_pair: handles return_all by returning lists of proper length""" # two allowed_perturbations a = "ACGT" aln = ArrayAlignment( data={0: "AA", 1: "AC", 2: "CG", 3: "CT", 4: "TA"}, moltype=DNA ) actual = sca_pair( aln, 0, 1, cutoff=0.33, return_all=True, alphabet=a, background_freqs=self.dna_base_freqs, ) self.assertEqual(len(actual), 2) self.assertEqual(actual[0][0], "A") self.assertEqual(actual[1][0], "C") # one allowed_perturbations a = "ACGT" aln = ArrayAlignment( data={0: "AA", 1: "AC", 2: "AG", 3: "CT", 4: "TA"}, moltype=DNA ) actual = sca_pair( aln, 0, 1, 0.33, return_all=True, alphabet=a, background_freqs=self.dna_base_freqs, ) self.assertEqual(len(actual), 1) self.assertEqual(actual[0][0], "A") # zero allowed_perturbations actual = sca_pair( aln, 0, 1, 1.0, return_all=True, alphabet=a, background_freqs=self.dna_base_freqs, ) # expected = [('A',-1),('C',-1)] expected = DEFAULT_NULL_VALUE assert_allclose(actual, expected) # pos1 == pos2 actual = sca_pair( aln, 0, 0, 0.33, return_all=True, alphabet=a, background_freqs=self.dna_base_freqs, ) actual = list(zip(*actual)) expected = list(zip(*[("A", 2.40381185618)])) assert_equal(actual[0], expected[0]) assert_allclose(actual[1], expected[1]) def test_sca_pair_error(self): """sca_pair:returns w/ error when appropriate""" a = "ACGT" # pos1 out of range self.assertRaises( ValueError, coevolve_pair, sca_pair, self.dna_aln, 100, 1, cutoff=0.50, alphabet=a, background_freqs=self.dna_base_freqs, ) # pos2 out of range self.assertRaises( ValueError, coevolve_pair, sca_pair, self.dna_aln, 0, 100, cutoff=0.50, alphabet=a, background_freqs=self.dna_base_freqs, ) # pos1 & pos2 out of range self.assertRaises( ValueError, coevolve_pair, sca_pair, self.dna_aln, 100, 100, cutoff=0.50, alphabet=a, background_freqs=self.dna_base_freqs, ) # bad cut-off self.assertRaises( ValueError, coevolve_pair, sca_pair, self.dna_aln, 0, 1, cutoff=1.2, alphabet=a, background_freqs=self.dna_base_freqs, ) # incompatible alphabet and background freqs self.assertRaises( ValueError, coevolve_pair, sca_pair, self.dna_aln, 0, 1, cutoff=0.2, alphabet=a, ) self.assertRaises( ValueError, coevolve_pair, sca_pair, self.dna_aln, 0, 1, cutoff=0.2, alphabet="ACGTBC", background_freqs=self.dna_base_freqs, ) def test_sca_position_no_error(self): """sca_position: returns w/o error""" r = sca_position( self.dna_aln, 1, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs ) # sanity check -- coupling w/ self assert_allclose(r[1], 3.087, 0.01) r = sca_position( self.dna_aln_gapped, 1, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) assert_allclose(r[1], 3.387, 0.01) # same tests, but called via coevolve_position r = coevolve_position( sca_position, self.dna_aln, 1, cutoff=0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) # sanity check -- coupling w/ self assert_allclose(r[1], 3.087, 0.01) r = coevolve_position( sca_position, self.dna_aln_gapped, 1, cutoff=0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) # sanity check -- coupling w/ self assert_allclose(r[1], 3.387, 0.01) def test_sca_position_error(self): """sca_position: returns w/ error when appropriate""" a = "ACGT" # position out of range self.assertRaises( ValueError, coevolve_position, sca_position, self.dna_aln, 100, cutoff=0.50, alphabet=a, background_freqs=self.dna_base_freqs, ) # bad cutoff self.assertRaises( ValueError, coevolve_position, sca_position, self.dna_aln, 1, cutoff=-8.2, alphabet=a, background_freqs=self.dna_base_freqs, ) # incompatible alphabet and background freqs self.assertRaises( ValueError, coevolve_position, sca_position, self.dna_aln, 0, cutoff=0.2, alphabet=a, ) self.assertRaises( ValueError, coevolve_position, sca_position, self.dna_aln, 0, cutoff=0.2, alphabet="ACGTBC", background_freqs=self.dna_base_freqs, ) def test_sca_position_returns_same_as_sca_pair(self): """sca_position: returns same as sca_pair called on each pos""" expected = [] for i in range(len(self.dna_aln)): expected.append( sca_pair( self.dna_aln, 1, i, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) ) actual = sca_position( self.dna_aln, 1, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs ) assert_allclose(actual, expected) # change some of the defaults to make sure they make it through bg_freqs = {"A": 0.50, "C": 0.50} expected = [] for i in range(len(self.dna_aln)): expected.append( sca_pair( self.dna_aln, 1, i, 0.50, alphabet="AC", null_value=52.0, scaled_aln_size=20, background_freqs=bg_freqs, ) ) actual = sca_position( self.dna_aln, 1, 0.50, alphabet="AC", null_value=52.0, scaled_aln_size=20, background_freqs=bg_freqs, ) assert_allclose(actual, expected) def test_sca_alignment_no_error(self): """sca_alignment: returns w/o error""" r = sca_alignment( self.dna_aln, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs ) # sanity check -- coupling w/ self assert_allclose(r[0][0], 2.32222608171) # same test, but called via coevolve_alignment r = coevolve_alignment( sca_alignment, self.dna_aln, cutoff=0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) # sanity check -- coupling w/ self assert_allclose(r[0][0], 2.32222608171) def test_sca_alignment_error(self): """sca_alignment: returns w/ error when appropriate""" a = "ACGT" # incompatible alphabet and background freqs self.assertRaises( ValueError, coevolve_position, sca_position, self.dna_aln, 0, cutoff=0.2, alphabet=a, ) self.assertRaises( ValueError, coevolve_position, sca_position, self.dna_aln, 0, cutoff=0.2, alphabet="ACGTBC", background_freqs=self.dna_base_freqs, ) def test_sca_alignment_returns_same_as_sca_position(self): """sca_alignment: returns same as sca_position on every position""" expected = [] for i in range(len(self.dna_aln)): expected.append( sca_position( self.dna_aln, i, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs, ) ) actual = sca_alignment( self.dna_aln, 0.50, alphabet="ACGT", background_freqs=self.dna_base_freqs ) assert_allclose(actual, expected) # change some of the defaults to make sure they make it through bg_freqs = {"A": 0.50, "C": 0.50} expected = [] for i in range(len(self.dna_aln)): expected.append( sca_position( self.dna_aln, i, 0.50, alphabet="AC", null_value=52.0, scaled_aln_size=20, background_freqs=bg_freqs, ) ) actual = sca_alignment( self.dna_aln, 0.50, alphabet="AC", null_value=52.0, scaled_aln_size=20, background_freqs=bg_freqs, ) assert_allclose(actual, expected) def test_sca_pair_gpcr(self): """sca_pair: reproduces several GPCR data from Suel et al., 2003""" assert_allclose(sca_pair(self.gpcr_aln, 295, 18, 0.32), 0.12, 0.1) assert_allclose(sca_pair(self.gpcr_aln, 295, 124, 0.32), 1.86, 0.1) assert_allclose(sca_pair(self.gpcr_aln, 295, 304, 0.32), 0.3, 0.1) # covariation w/ self assert_allclose(sca_pair(self.gpcr_aln, 295, 295, 0.32), 7.70358628) def test_sca_position_gpcr(self): """sca_position: reproduces several GPCR data from Suel et al., 2003""" if not self.run_slow_tests: return vector = sca_position(self.gpcr_aln, 295, 0.32) assert_allclose(vector[18], 0.12, 0.1) assert_allclose(vector[124], 1.86, 0.1) assert_allclose(vector[304], 0.3, 0.1) # covariation w/ self == null_value assert_allclose(vector[295], nan) def test_ltm_to_symmetric(self): """ltm_to_symmetric: making ltm matrices symmetric functions""" m = arange(9).reshape((3, 3)) expected = [[0, 3, 6], [3, 4, 7], [6, 7, 8]] assert_equal(ltm_to_symmetric(m), expected) # non-square matrices not supported self.assertRaises(AssertionError, ltm_to_symmetric, arange(10).reshape(5, 2)) self.assertRaises(AssertionError, ltm_to_symmetric, arange(10).reshape(2, 5)) def test_merge_alignments(self): """merging alignments of same moltype functions as expected""" # PROTEIN aln1 = ArrayAlignment(data={"1": "AC", "2": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1": "EF", "2": "EG"}, moltype=PROTEIN) combined_aln = ArrayAlignment(data={"1": "ACEF", "2": "ADEG"}, moltype=PROTEIN) actual = merge_alignments(aln1, aln2) self.assertEqual(actual, combined_aln) self.assertEqual(actual.moltype, PROTEIN) # RNA aln1 = ArrayAlignment(data={"1": "AC", "2": "AU"}, moltype=RNA) aln2 = ArrayAlignment(data={"1": "GG", "2": "UG"}, moltype=RNA) combined_aln = ArrayAlignment(data={"1": "ACGG", "2": "AUUG"}, moltype=RNA) actual = merge_alignments(aln1, aln2) self.assertEqual(actual, combined_aln) self.assertEqual(actual.moltype, RNA) # DNA aln1 = ArrayAlignment(data={"1": "AC", "2": "AT"}, moltype=DNA) aln2 = ArrayAlignment(data={"1": "GG", "2": "TG"}, moltype=DNA) combined_aln = ArrayAlignment(data={"1": "ACGG", "2": "ATTG"}, moltype=DNA) actual = merge_alignments(aln1, aln2) self.assertEqual(actual, combined_aln) self.assertEqual(actual.moltype, DNA) def test_merge_alignments_ignores_id_following_plus(self): """merge_alignments ignores all seq id characters after '+'""" aln1 = ArrayAlignment(data={"1+a": "AC", "2+b": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1 + c": "EFW", "2 + d": "EGY"}, moltype=PROTEIN) combined_aln = ArrayAlignment( data={"1": "ACEFW", "2": "ADEGY"}, moltype=PROTEIN ) self.assertEqual(merge_alignments(aln1, aln2), combined_aln) # not all ids have a + aln1 = ArrayAlignment(data={"1": "AC", "2+b": "AD"}, moltype=PROTEIN) aln2 = ArrayAlignment(data={"1+c": "EFW", "2": "EGY"}, moltype=PROTEIN) combined_aln = ArrayAlignment( data={"1": "ACEFW", "2": "ADEGY"}, moltype=PROTEIN ) self.assertEqual(merge_alignments(aln1, aln2), combined_aln) def test_merge_alignments_different_moltype(self): """merging alignments of different moltype functions as expected""" aln1 = ArrayAlignment(data={"1": "AC", "2": "AU"}, moltype=RNA) aln2 = ArrayAlignment(data={"1": "EF", "2": "EG"}, moltype=PROTEIN) combined_aln = ArrayAlignment(data={"1": "ACEF", "2": "AUEG"}) self.assertEqual(merge_alignments(aln1, aln2), combined_aln) aln1 = ArrayAlignment(data={"1": "AC", "2": "AT"}, moltype=DNA) aln2 = ArrayAlignment(data={"1": "EF", "2": "EG"}, moltype=PROTEIN) combined_aln = ArrayAlignment(data={"1": "ACEF", "2": "ATEG"}) self.assertEqual(merge_alignments(aln1, aln2), combined_aln) aln1 = ArrayAlignment(data={"1": "AC", "2": "AT"}, moltype=DNA) aln2 = ArrayAlignment(data={"1": "UC", "2": "UG"}, moltype=RNA) combined_aln = ArrayAlignment(data={"1": "ACUC", "2": "ATUG"}) self.assertEqual(merge_alignments(aln1, aln2), combined_aln) def test_n_random_seqs(self): """n_random_seqs: functions as expected""" aln1 = make_aligned_seqs( data=list(zip(list("abcd"), ["AA", "AC", "DD", "GG"])), moltype=PROTEIN, array_align=True, ) # Number of returned sequences correct self.assertEqual(n_random_seqs(aln1, 1).num_seqs, 1) self.assertEqual(n_random_seqs(aln1, 2).num_seqs, 2) self.assertEqual(n_random_seqs(aln1, 3).num_seqs, 3) self.assertEqual(n_random_seqs(aln1, 4).num_seqs, 4) # Sequences are correct new_aln = n_random_seqs(aln1, 3) self.assertEqual(new_aln.num_seqs, 3) for n in new_aln.names: self.assertEqual(new_aln.get_seq(n), aln1.get_seq(n)) # Objects are equal when all are requested self.assertEqual(n_random_seqs(aln1, 4), aln1) # Objects are not equal when subset are requested self.assertNotEqual(n_random_seqs(aln1, 3), aln1) # In 1000 iterations, we get at least one different alignment -- # this tests the random selection different = False new_aln = n_random_seqs(aln1, 2) for i in range(1000): new_aln2 = n_random_seqs(aln1, 2) if new_aln != new_aln2: different = True break self.assertTrue(different) class AncestorCoevolve(TestCase): """Tests of the ancestral state method for detecting coevolution""" def setUp(self): """ """ # t1, ancestral_states1, and aln1_* are used to test that when # alternate seqs are used with the same tree and ancestral_states, # the results vary when appropriate self.t1 = make_tree( treestring="((A:0.5,B:0.5):0.5,(C:0.5,(D:0.5,E:0.5):0.5):0.5);" ) self.ancestral_states1 = ArrayAlignment( data={"root": "AAA", "edge.0": "AAA", "edge.1": "AAA", "edge.2": "AAA"}, moltype=PROTEIN, ) self.ancestral_states1_w_gaps = ArrayAlignment( data={"root": "AAA", "edge.0": "AAA", "edge.1": "A-A", "edge.2": "AA-"}, moltype=PROTEIN, ) # no correlated changes count self.aln1_1 = ArrayAlignment( data={"A": "AAC", "B": "AAD", "C": "AAA", "D": "AAE", "E": "AFA"}, moltype=PROTEIN, ) # 1 correlated change count self.aln1_2 = ArrayAlignment( data={"A": "AAC", "B": "AAD", "C": "AAA", "D": "AEE", "E": "AFF"}, moltype=PROTEIN, ) # 1 different correlated change count self.aln1_3 = ArrayAlignment( data={"A": "AAC", "B": "AAD", "C": "AAA", "D": "AGE", "E": "AFH"}, moltype=PROTEIN, ) # 3 correlated change counts self.aln1_4 = ArrayAlignment( data={"A": "AAC", "B": "AGD", "C": "AAA", "D": "AGE", "E": "AFH"}, moltype=PROTEIN, ) # 8 correlated change counts self.aln1_5 = ArrayAlignment( data={"A": "YYC", "B": "HGD", "C": "AAA", "D": "AGE", "E": "AFH"}, moltype=PROTEIN, ) self.aln1_w_gaps = ArrayAlignment( data={"A": "AAC", "B": "AAD", "C": "AAA", "D": "AG-", "E": "A-H"}, moltype=PROTEIN, ) # t2, ancestral_states2_*, and aln2 are used to test that when # alternate ancestral states are used with the same aln and tree, # the results vary when appropriate self.t2 = make_tree(treestring="(A:0.5,B:0.5,C:0.5);") self.ancestral_states2_1 = ArrayAlignment(data={"root": "AA"}, moltype=PROTEIN) self.ancestral_states2_2 = ArrayAlignment(data={"root": "CC"}, moltype=PROTEIN) self.ancestral_states2_3 = ArrayAlignment(data={"root": "EF"}, moltype=PROTEIN) self.aln2 = ArrayAlignment( data={"A": "AA", "B": "CC", "C": "CA"}, moltype=PROTEIN ) # t3_*, ancestral_states3, and aln3 are used to test that when # alternate trees are used with the same aln and ancestral_states, # the results vary when appropriate self.t3_1 = make_tree(treestring="(A:0.5,(B:0.5,C:0.5):0.5);") self.t3_2 = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") self.ancestral_states3 = ArrayAlignment( data={"root": "CC", "edge.0": "AD"}, moltype=PROTEIN ) self.aln3 = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC"}, moltype=PROTEIN ) def test_validate_ancestral_seqs_invalid(self): """validate_ancestral_seqs: ValueError on incompatible anc. seqs & tree""" # edge missing aln = ArrayAlignment(data={"A": "AC", "B": "CA", "C": "CC"}, moltype=PROTEIN) self.assertRaises( ValueError, validate_ancestral_seqs, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);"), ancestral_seqs=ArrayAlignment(data={"root": "AA"}, moltype=PROTEIN), ) # root missing self.assertRaises( ValueError, validate_ancestral_seqs, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);"), ancestral_seqs=ArrayAlignment(data={"edge.0": "AA"}, moltype=PROTEIN), ) # correct numSeqs but wrong names self.assertRaises( ValueError, validate_ancestral_seqs, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);"), ancestral_seqs=ArrayAlignment( data={"root": "AA", "edge.1": "AA"}, moltype=PROTEIN ), ) self.assertRaises( ValueError, validate_ancestral_seqs, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);"), ancestral_seqs=ArrayAlignment( data={"r": "AA", "edge.0": "AA"}, moltype=PROTEIN ), ) self.assertRaises( ValueError, validate_ancestral_seqs, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);"), ancestral_seqs=ArrayAlignment(data={"r": "AA", "e": "AA"}, moltype=PROTEIN), ) # different tree: invalid aln = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC", "D": "DD"}, moltype=PROTEIN ) self.assertRaises( ValueError, validate_ancestral_seqs, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);"), ancestral_seqs=ArrayAlignment( data={"root": "AA", "e": "AA", "edge.1": "AA"}, moltype=PROTEIN ), ) def test_validate_ancestral_seqs_valid(self): """validate_ancestral_seqs: does nothing on compatible anc. seqs & tree""" aln = ArrayAlignment(data={"A": "AC", "B": "CA", "C": "CC"}, moltype=PROTEIN) # valid data -> no error validate_ancestral_seqs( aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);"), ancestral_seqs=ArrayAlignment( data={"root": "AA", "edge.0": "AA"}, moltype=PROTEIN ), ) # different tree: valid aln = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC", "D": "DD"}, moltype=PROTEIN ) validate_ancestral_seqs( aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);"), ancestral_seqs=ArrayAlignment( data={"root": "AA", "edge.0": "AA", "edge.1": "AA"}, moltype=PROTEIN ), ) def test_ancestral_states_input_validation(self): """ancestral_states_input_validation: all validation steps performed""" aln = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC", "D": "DD"}, moltype=PROTEIN ) # incompatible tree and ancestral states (more thorough testing in # test_validate_ancestral_seqs) self.assertRaises( ValueError, ancestral_states_input_validation, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);"), ancestral_seqs=ArrayAlignment( data={"root": "AA", "e": "AA", "edge.1": "AA"}, moltype=PROTEIN ), ) # no tree provided self.assertRaises( ValueError, ancestral_states_input_validation, aln, ancestral_seqs=ArrayAlignment( data={"root": "AA", "e": "AA", "edge.1": "AA"}, moltype=PROTEIN ), ) # incompatible tree and alignment (more tests in test_validate_tree) aln = ArrayAlignment(data={"A": "AC", "B": "CA", "C": "CC"}, moltype=PROTEIN) self.assertRaises( ValueError, ancestral_states_input_validation, aln, tree=make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);"), ) def test_validate_tree_valid(self): """validate_tree: does nothing on compatible tree and aln""" t = make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);") aln = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC", "D": "DD"}, moltype=PROTEIN ) validate_tree(aln, t) t = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AC", "B": "CA", "C": "CC"}, moltype=PROTEIN) validate_tree(aln, t) def test_validate_tree_invalid(self): """validate_tree: raises ValueError on incompatible tree and aln""" # different scale tree and aln t = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") aln = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC", "D": "DD"}, moltype=PROTEIN ) self.assertRaises(ValueError, validate_tree, aln, t) t = make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,D:0.5):0.5);") aln = ArrayAlignment(data={"A": "AC", "B": "CA", "C": "CC"}, moltype=PROTEIN) self.assertRaises(ValueError, validate_tree, aln, t) # same scale tree and aln, but different names t = make_tree(treestring="((A:0.5,B:0.5):0.5,(C:0.5,Dee:0.5):0.5);") aln = ArrayAlignment( data={"A": "AC", "B": "CA", "C": "CC", "D": "DD"}, moltype=PROTEIN ) self.assertRaises(ValueError, validate_tree, aln, t) def test_get_ancestral_seqs(self): """get_ancestral_seqs: returns valid collection of ancestral seqs""" t = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AA", "B": "AA", "C": "AC"}, moltype=PROTEIN) expected = ArrayAlignment(data={"root": "AA", "edge.0": "AA"}, moltype=PROTEIN) self.assertEqual(get_ancestral_seqs(aln, t, optimise=False), expected) t = make_tree(treestring="(A:0.5,B:0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AA", "B": "AA", "C": "AC"}, moltype=PROTEIN) expected = ArrayAlignment(data={"root": "AA"}, moltype=PROTEIN) self.assertEqual(get_ancestral_seqs(aln, t, optimise=False), expected) t = make_tree( treestring="(((A1:0.5,A2:0.5):0.5,B:0.5):0.5,\ (C:0.5,D:0.5):0.5);" ) aln = ArrayAlignment( data={"A1": "AD", "A2": "AD", "B": "AC", "C": "AC", "D": "AC"}, moltype=PROTEIN, ) expected = ArrayAlignment( data={"root": "AC", "edge.0": "AD", "edge.1": "AC", "edge.2": "AC"}, moltype=PROTEIN, ) self.assertEqual(get_ancestral_seqs(aln, t, optimise=False), expected) def test_get_ancestral_seqs_handles_gaps(self): """get_ancestral_seqs: handles gaps""" # gaps handled OK t = make_tree(treestring="(A:0.5,B:0.5,C:0.5);") aln = ArrayAlignment(data={"A": "A-", "B": "AA", "C": "AA"}, moltype=PROTEIN) expected = ArrayAlignment(data={"root": "AA"}, moltype=PROTEIN) self.assertEqual(get_ancestral_seqs(aln, t, optimise=False), expected) def test_get_ancestral_seqs_handles_ambiguous_residues(self): """get_ancestral_seqs: handles ambiguous residues""" # Non-canonical residues handled OK t = make_tree(treestring="(A:0.5,B:0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AX", "B": "Z-", "C": "BC"}, moltype=PROTEIN) actual = get_ancestral_seqs(aln, t, optimise=False) self.assertEqual(len(actual), 2) self.assertEqual(actual.num_seqs, 1) def test_ancestral_state_alignment_handles_ancestral_state_calc(self): """ancestral_state_alignment: functions when calc'ing ancestral states""" t = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AA", "B": "AA", "C": "AC"}, moltype=PROTEIN) assert_equal(ancestral_state_alignment(aln, t), [[0, 0], [0, 2]]) # non-bifurcating tree t = make_tree(treestring="(A:0.5,B:0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AA", "B": "AA", "C": "AC"}, moltype=PROTEIN) assert_equal(ancestral_state_alignment(aln, t), [[0, 0], [0, 2]]) def test_ancestral_state_position_handles_ancestral_state_calc(self): """ancestral_state_position: functions when calc'ing ancestral states""" t = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AA", "B": "AA", "C": "AC"}, moltype=PROTEIN) assert_equal(ancestral_state_position(aln, t, 0), [0, 0]) assert_equal(ancestral_state_position(aln, t, 1), [0, 2]) def test_ancestral_state_pair_handles_ancestral_state_calc(self): """ancestral_state_position: functions when calc'ing ancestral states""" t = make_tree(treestring="((A:0.5,B:0.5):0.5,C:0.5);") aln = ArrayAlignment(data={"A": "AA", "B": "AA", "C": "AC"}, moltype=PROTEIN) self.assertEqual(ancestral_state_pair(aln, t, 0, 0), 0) self.assertEqual(ancestral_state_pair(aln, t, 0, 1), 0) self.assertEqual(ancestral_state_pair(aln, t, 1, 1), 2) self.assertEqual(ancestral_state_pair(aln, t, 1, 0), 0) def test_ancestral_state_alignment_no_error_on_gap(self): """ancestral_state_alignment: return w/o error with gapped seqs""" ancestral_state_alignment(self.aln1_w_gaps, self.t1, self.ancestral_states1) ancestral_state_alignment(self.aln1_1, self.t1, self.ancestral_states1_w_gaps) def test_ancestral_state_methods_handle_bad_ancestor_aln(self): """ancestral state methods raise error on bad ancestor alignment""" # bad length and seq names self.assertRaises( ValueError, coevolve_alignment, ancestral_state_alignment, self.aln1_2, tree=self.t1, ancestral_seqs=self.ancestral_states2_1, ) self.assertRaises( ValueError, coevolve_position, ancestral_state_position, self.aln1_2, 0, tree=self.t1, ancestral_seqs=self.ancestral_states2_1, ) self.assertRaises( ValueError, coevolve_pair, ancestral_state_pair, self.aln1_2, 0, 1, tree=self.t1, ancestral_seqs=self.ancestral_states2_1, ) # bad seq names self.assertRaises( ValueError, coevolve_alignment, ancestral_state_alignment, self.aln1_2, tree=self.t1, ancestral_seqs=self.aln1_2, ) self.assertRaises( ValueError, coevolve_position, ancestral_state_position, self.aln1_2, 0, tree=self.t1, ancestral_seqs=self.aln1_2, ) self.assertRaises( ValueError, coevolve_pair, ancestral_state_pair, self.aln1_2, 0, 1, tree=self.t1, ancestral_seqs=self.aln1_2, ) # bad length a = ArrayAlignment( data={"root": "AC", "edge.0": "AD", "edge.1": "AA", "edge.2": "EE"} ) self.assertRaises( ValueError, coevolve_alignment, ancestral_state_alignment, self.aln1_2, tree=self.t1, ancestral_seqs=a, ) self.assertRaises( ValueError, coevolve_position, ancestral_state_position, self.aln1_2, 0, tree=self.t1, ancestral_seqs=a, ) self.assertRaises( ValueError, coevolve_pair, ancestral_state_pair, self.aln1_2, 0, 1, tree=self.t1, ancestral_seqs=a, ) def test_ancestral_states_methods_handle_bad_position_numbers(self): """coevolve_* w/ ancestral_states raise ValueError on bad position""" self.assertRaises( ValueError, coevolve_position, ancestral_state_position, self.aln1_2, 42, tree=self.t1, ancestral_states=self.ancestral_states2_1, ) self.assertRaises( ValueError, coevolve_pair, ancestral_state_pair, self.aln1_2, 0, 42, tree=self.t1, ancestral_states=self.ancestral_states2_1, ) self.assertRaises( ValueError, coevolve_pair, ancestral_state_pair, self.aln1_2, 42, 0, tree=self.t1, ancestral_states=self.ancestral_states2_1, ) def test_ancestral_state_alignment_non_bifurcating_tree(self): """ancestral_state_alignment: handles non-bifurcating tree correctly""" assert_equal( ancestral_state_alignment(self.aln2, self.t2, self.ancestral_states2_3), [[9, 9], [9, 9]], ) def test_ancestral_state_alignment_bifurcating_tree(self): """ancestral_state_alignment: handles bifurcating tree correctly""" assert_allclose( ancestral_state_alignment(self.aln1_5, self.t1, self.ancestral_states1), [[5, 5, 5], [5, 11.6, 11.6], [5, 11.6, 11.6]], ) def test_ancestral_state_alignment_ancestor_difference(self): """ancestral_state_alignment: different ancestor -> different result""" # ancestral_states2_1 assert_equal( ancestral_state_alignment(self.aln2, self.t2, self.ancestral_states2_1), [[5, 2], [2, 2]], ) # ancestral_states2_2 assert_equal( ancestral_state_alignment(self.aln2, self.t2, self.ancestral_states2_2), [[2, 2], [2, 5]], ) # ancestral_states2_3 assert_equal( ancestral_state_alignment(self.aln2, self.t2, self.ancestral_states2_3), [[9, 9], [9, 9]], ) def test_ancestral_state_position_ancestor_difference(self): """ancestral_state_position: difference_ancestor -> different result""" # ancestral_states2_1 assert_equal( ancestral_state_position(self.aln2, self.t2, 0, self.ancestral_states2_1), [5, 2], ) assert_equal( ancestral_state_position(self.aln2, self.t2, 1, self.ancestral_states2_1), [2, 2], ) # ancestral_states2_2 assert_equal( ancestral_state_position(self.aln2, self.t2, 0, self.ancestral_states2_2), [2, 2], ) assert_equal( ancestral_state_position(self.aln2, self.t2, 1, self.ancestral_states2_2), [2, 5], ) # ancestral_states2_3 assert_equal( ancestral_state_position(self.aln2, self.t2, 0, self.ancestral_states2_3), [9, 9], ) assert_equal( ancestral_state_position(self.aln2, self.t2, 1, self.ancestral_states2_3), [9, 9], ) def test_ancestral_state_pair_ancestor_difference(self): """ancestral_state_pair: difference_ancestor -> different result""" # ancestral_states2_1 self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 0, 0, self.ancestral_states2_1), 5 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 0, 1, self.ancestral_states2_1), 2 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 1, 1, self.ancestral_states2_1), 2 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 1, 0, self.ancestral_states2_1), 2 ) # ancestral_states2_2 self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 0, 0, self.ancestral_states2_2), 2 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 0, 1, self.ancestral_states2_2), 2 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 1, 1, self.ancestral_states2_2), 5 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 1, 0, self.ancestral_states2_2), 2 ) # ancestral_states2_3 self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 0, 0, self.ancestral_states2_3), 9 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 0, 1, self.ancestral_states2_3), 9 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 1, 1, self.ancestral_states2_3), 9 ) self.assertEqual( ancestral_state_pair(self.aln2, self.t2, 1, 0, self.ancestral_states2_3), 9 ) def test_ancestral_state_alignment_tree_difference(self): """ancestral_state_alignment: different result on different tree""" # tree: t3_1 assert_equal( ancestral_state_alignment(self.aln3, self.t3_1, self.ancestral_states3), [[7, 5], [5, 5]], ) # tree: t3_2 assert_equal( ancestral_state_alignment(self.aln3, self.t3_2, self.ancestral_states3), [[2, 2], [2, 5]], ) def test_ancestral_state_position_tree_difference(self): """ancestral_state_position: different result on different tree""" # tree: t3_1 assert_equal( ancestral_state_position(self.aln3, self.t3_1, 0, self.ancestral_states3), [7, 5], ) assert_equal( ancestral_state_position(self.aln3, self.t3_1, 1, self.ancestral_states3), [5, 5], ) # tree: t3_2 assert_equal( ancestral_state_position(self.aln3, self.t3_2, 0, self.ancestral_states3), [2, 2], ) assert_equal( ancestral_state_position(self.aln3, self.t3_2, 1, self.ancestral_states3), [2, 5], ) def test_ancestral_state_pair_tree_difference(self): """ancestral_state_pair: different result on different tree""" # tree: t3_1 assert_allclose( ancestral_state_pair(self.aln3, self.t3_1, 0, 1, self.ancestral_states3), 5 ) assert_allclose( ancestral_state_pair(self.aln3, self.t3_1, 1, 0, self.ancestral_states3), 5 ) assert_allclose( ancestral_state_pair(self.aln3, self.t3_1, 0, 0, self.ancestral_states3), 7 ) assert_allclose( ancestral_state_pair(self.aln3, self.t3_1, 1, 1, self.ancestral_states3), 5 ) # tree: t3_2 assert_allclose( ancestral_state_pair(self.aln3, self.t3_2, 0, 1, self.ancestral_states3), 2 ) assert_allclose( ancestral_state_pair(self.aln3, self.t3_2, 1, 0, self.ancestral_states3), 2 ) assert_allclose( ancestral_state_pair(self.aln3, self.t3_2, 0, 0, self.ancestral_states3), 2 ) assert_allclose( ancestral_state_pair(self.aln3, self.t3_2, 1, 1, self.ancestral_states3), 5 ) def test_ancestral_state_alignment_aln_difference(self): """ancestral_state_alignment: difference aln -> different result""" expected = [[0, 0, 0], [0, 2, 0], [0, 0, 7.8]] actual = ancestral_state_alignment(self.aln1_1, self.t1, self.ancestral_states1) assert_allclose(actual, expected) expected = [[5, 5, 5], [5, 11.6, 11.6], [5, 11.6, 11.6]] actual = ancestral_state_alignment(self.aln1_5, self.t1, self.ancestral_states1) assert_allclose(actual, expected) def test_ancestral_state_position_aln_difference(self): """ancestral_state_position: difference aln -> different result""" expected = [0, 0, 0] actual = ancestral_state_position( self.aln1_1, self.t1, 0, self.ancestral_states1 ) assert_allclose(actual, expected) expected = [0, 2, 0] actual = ancestral_state_position( self.aln1_1, self.t1, 1, self.ancestral_states1 ) assert_allclose(actual, expected) expected = [0, 0, 7.8] actual = ancestral_state_position( self.aln1_1, self.t1, 2, self.ancestral_states1 ) assert_allclose(actual, expected) expected = [5, 5, 5] actual = ancestral_state_position( self.aln1_5, self.t1, 0, self.ancestral_states1 ) assert_allclose(actual, expected) expected = [5, 11.6, 11.6] actual = ancestral_state_position( self.aln1_5, self.t1, 1, self.ancestral_states1 ) assert_allclose(actual, expected) expected = [5, 11.6, 11.6] actual = ancestral_state_position( self.aln1_5, self.t1, 2, self.ancestral_states1 ) assert_allclose(actual, expected) def test_ancestral_state_pair_aln_difference(self): """acestral_state_pair: different aln -> different result""" assert_allclose( ancestral_state_pair(self.aln1_1, self.t1, 0, 0, self.ancestral_states1), 0 ) assert_allclose( ancestral_state_pair(self.aln1_1, self.t1, 1, 1, self.ancestral_states1), 2 ) assert_allclose( ancestral_state_pair(self.aln1_1, self.t1, 2, 2, self.ancestral_states1), 7.8, ) assert_allclose( ancestral_state_pair(self.aln1_5, self.t1, 0, 1, self.ancestral_states1), 5 ) assert_allclose( ancestral_state_pair(self.aln1_5, self.t1, 0, 2, self.ancestral_states1), 5 ) assert_allclose( ancestral_state_pair(self.aln1_5, self.t1, 1, 2, self.ancestral_states1), 11.6, ) def test_ancestral_state_pair_symmetry(self): """ancestral_state_pair: value[i,j] == value[j,i]""" assert_allclose( ancestral_state_pair(self.aln1_5, self.t1, 0, 1, self.ancestral_states1), ancestral_state_pair(self.aln1_5, self.t1, 1, 0, self.ancestral_states1), ) assert_allclose( ancestral_state_pair(self.aln1_5, self.t1, 0, 2, self.ancestral_states1), ancestral_state_pair(self.aln1_5, self.t1, 2, 0, self.ancestral_states1), ) assert_allclose( ancestral_state_pair(self.aln1_5, self.t1, 1, 2, self.ancestral_states1), ancestral_state_pair(self.aln1_5, self.t1, 2, 1, self.ancestral_states1), ) def est_ancestral_state_methods_handle_alt_null_value(self): """ancetral state methods handle non-default null value""" # need to rewrite a test of this -- right now there's no way to get # null values into the ancestral states result, but that will change # when I fix the exclude handling pass # following are support funcs for ResampledMiTests def make_freqs(c12): c1, c2 = CategoryCounter(), CategoryCounter() for a, b in c12.expand(): c1[a] += 1 c2[b] += 1 return c1, c2 def make_sample(freqs): d = [] for i, s in enumerate(freqs.expand()): d += [("s%d" % i, s)] return make_aligned_seqs(data=d) def _calc_mi(): """one mutual info hand calc""" from math import log i = 37 / 42 * -log(37 / 42, 2) - (5 / 42 * log(5 / 42, 2)) j = 39 / 42 * -log(39 / 42, 2) - (3 / 42 * log(3 / 42, 2)) k = ( 34 / 42 * -log(34 / 42, 2) - (3 / 42 * log(3 / 42, 2)) - (5 / 42 * log(5 / 42, 2)) ) return i + j - k class ResampledMiTests(TestCase): def setUp(self): self.c12 = CategoryCounter(["AA", "AA", "BB", "BB", "BC"]) self.c1, self.c2 = make_freqs(self.c12) self.aln = make_sample(self.c12) def test_calc_weights(self): """resampled mi weights should be correctly computed""" w1 = make_weights(self.c1, 5) w2 = make_weights(self.c2, 5) e = [ ("A", {"C": 0.033333333333333333, "B": 0.066666666666666666}), ("B", {"A": 0.066666666666666666, "C": 0.033333333333333333}), ("C", {"A": 0.050000000000000003, "B": 0.050000000000000003}), ] weights = [] for w in w1, w2: for k, d in w: weights += list(d.values()) assert_allclose(sum(weights), 0.5) w2.sort() self.assertEqual(w2, e) def test_scaled_mi(self): """resampled mi should match hand calc""" def calc_scaled(data, expected_smi): col_i, col_j = CategoryCounter(), CategoryCounter() for i, j in data: col_i[i] += 1 col_j[j] += 1 pair_freqs = CategoryCounter(data) weights_i = make_weights(col_i, col_i.sum) weights_j = make_weights(col_j, col_j.sum) entropy = mi(col_i.entropy, col_j.entropy, pair_freqs.entropy) assert_allclose(entropy, _calc_mi()) scales = calc_pair_scale(data, col_i, col_j, weights_i, weights_j) scaled_mi = 1 - sum( [w * pair_freqs[pr] for pr, e, w in scales if entropy <= e] ) assert_allclose(scaled_mi, expected_smi) data = [ "BN", "BN", "BP", "BN", "PN", "BN", "BN", "BN", "BN", "BN", "BN", "BN", "BN", "PN", "BN", "PN", "BN", "BN", "BN", "BN", "BN", "BP", "BN", "BN", "BN", "BN", "BP", "BN", "BN", "BN", "BN", "PN", "PN", "BN", "BN", "BN", "BN", "BN", "BN", "BN", "BN", "BN", ] calc_scaled(data, 8 / 42) def test_resampled_mi_interface(self): """resampled_mi_alignment should correctly compute statistic from alignment""" arr = resampled_mi_alignment(self.aln) # expected value from hand calculation assert_allclose(arr.tolist(), [[1.0, 0.78333333], [0.78333333, 1.0]]) ALN_FILE = """Seq_1 ACDEFG Seq_2 STVWY- Seq_3 WY.ZBX""" # J in here ALN_FILE_WRONG_KEY = """Seq_1 ACDKLM Seq_2 JINCK- Seq_3 VX.MAB""" # last seq too long ALN_FILE_INC_SHAPE = """Seq_1 ACDKLM Seq_2 LINCK- Seq_3 VX.MABN""" gpcr_ungapped = """>OPSD_SPAAU MNGTEGPFFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWIMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFSIPLTIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVIAFLVCWLPYAGVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >B1AR_CANFA LPDGAATAARLLVPASPSASPLAPTSEGPAPLSQQWTAGIGLLMALIVLLIVAGNVLVIAAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVMRGRWEYGSFLCELWTSVDVLCVTASIETLCVIALDRYLAITAPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRRAFQRLLCCARRAARGSHGAAG------PPPSPG >OPSB_HUMAN ---MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTD---ESDTCSTVSSTQVGPN- >OPSD_PROCL NP-Y-GNFTVVDMAPKDILHMIHPHWYQYPPMNPMMYPLLLIFMLFTGILCLAGNFVTIWVFMNTKSLRTPANLLVVNLAMSDFLMMFTMFPPMMVTCYYHTWTLGPTFCQVYAFLGNLCGCASIWTMVFITFDRYNVIVKGVAGEPLSTKKASLWILTIWVLSITWCIAPFFGWNRYVPEGNLTGCGTD--YLSEDILSRSYLYDYSTWVYYLPLLP-IYCYVSIIKAVAAHMGIRNEEAQKTSAECRLAKIAMTTVALWFIAWTPYLLINWVGMFARSY-LSPVYTIWGYVFAKANAVYNPIVYAISHPKYRAAMEKKLPCLSCKTESDDVSESAEEKAESA---- >BRB1_RABIT ASQGPLELQPSNQSQLAPPNATSC--SGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSVFLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANLFISIFLVVAISQDRYSVLVHPMSRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRA-LN--SACILL---LPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRR---RVPSRCGGPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHEFTDLGLQLSNFSAFVNSCLNPVIYVFVGRLFRTKVWELCQQCSPR---------LAPV-------S >5H7_.ENLA NLLPSEFMTERPLNTTEQDLTKPDCGKELLLYGDTEKIVIGVVLSIITLFTIAGNALVIISVCIVKKLRQPSNYLVVSLAAADLSVAVAVMPFVIITDLVGGWLFGKVFCNVFIAMDVMCCTASIMTLCVISVDRYLGITRPLYPARQNGKLMAKMVFIVWLLSASITLPPLFGWAK--N-V--RVCLIS--------QDFGYTVYSTAVAFYIPMTVMLVMYQRIFVAAKISSKLDRKNISIFKREQKAARTLGIIVGAFTFCWLPFFLLSTARPFICGICMPLRLERTLLWLGYTNSLINPLIYAFFNRDLRTTFWNLLRCKYTNINRRLSAASTERHEGIL---- >B3AR_FELCA MAPWPHGNGSLASWPDAPTLTPNTANTSGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--HCCAFA--------SNIPYALLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALRTLGLIMGTFSLCWLPFFVANVVRALGGPS-VPSPAFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCRLEERHAAASGAAALTRPAESGLP >TLR1_DROME IIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVDPL-KRRTSRRKVRIILVLIWALSCVLSAPCLLYSS----SR--TVCFMMDGRYPTSMADYAYNLIILVLTTGIPMIVMLICYSLMGRVPGGSSIGTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPNSSNRHTRAETK >ITR_CATCO EQDFWSFNESSRNSTVGNETF-GNQTVNPLKRNEEVAKVEVTVLALVLFLALAGNLCVLIAIYTAKHTQSRMYYLMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQTVGMFASTYMLVLMSIDRCIAICQPL--RSLHKRKDRCYVIVSWALSLVFSVPQVYIFSLRE----VYDCWGD---FVQPWGAKAYITWISLTIYIIPVAILGGCYGLISFKIWQNANAVSSVKLVSKAKITTVKMTFVIVLAYIVCWTPFFFVQMWSAWDPEA-REAMPFIISMLLASLNSCCNPWIYMFFAGHLFHDLKQSLLCCSTLYLKSSQCRCKSNCSTYVIKST >NK1R_RANCA ----MNSNISAQNDSALNSTIQNGTKINQFIQPPWQIALWSVAYSIIVIVSLVGNIIVMWIIIAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNHWYYGLIYCKFHNFFPISAVFTSIYSMTAIALDRYMAIIHPL-KPRLSATATKIVICVIWSFSFCMAFPLGYYAD---GG---DICYLNPDSEENRKYEQVYQVLVFCLIYILPLLVIGCAYTFIGMTLWAS--PSDRYHEQVVAKRKVVKMMIVVVCTFAICWLPFHIFFLLQTLHEMTKFYQQFYLAIMWLAMSSTMYNPIIYCCLNDRFRIGFKHVFRWCPFIRAGEY----STRYLQTQSSMY >A2AA_MOUSE ----MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGQ-P--PSCKIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRRGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCP--VPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >MSHR_VULVU SGQGPQRRLLGSPNATSPTTPHFKLAANQTGPRCLEVSIPNGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYY----------------------NNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQHIARKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSW----------------------- >OPSD_BOVIN MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA >OPSG_MOUSE DHYEDSTHASIFTYTNSNSTKGPFEGPNYHIAPRWVYHLTSTWMILVVVASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAIWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILHLFGKKVDDS-----SELVSSV--SSVSPA >TA2R_RAT --MWLNS-----------TSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLTDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLT----LGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQ------------ >CCR3_HUMAN LENFSSSYDYGENESDSCCTSPPC---PQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHH-RL-ATHCQYN----FPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVL---------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGSRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPN----QRGL--------PSSS >THRR_CRILO LPEGRAIYLNKSHSPPAPLAPFISEDASGYLTSPWLRLFIPSVYTFVFVVSLPLNILAIAVFVLKMKVKKPAVVYMLHLAMADVLFVSVLPLKISYYFSGSDWQFGSGMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPISLSWRTLGRANFTCLVIWVMAIMGVVPLLLKEQTTR--N--TTCHDVLNETLLQGFYSYYFSAFSAVFFLVPLIISTICYMSIIRCL------SSSSVANRSKKSRALFLSAAVFCVFIVCFGPTNVLLIMHYLLLSDEKAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYGILCCKESSDPNSYNSTGDTCS-------- >AA2A_CAVPO ----------------------------------MSSSVYITVELVIAVLAILGNVLVCWAVWINSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFFACFVLVLTQSSIFSLLTITIDRYIAIRIPLYNGLVTCTRAKGIIAICWVLSFAIGLTPMLGWNNCSS-E-QVTCLFE-----DVVPMNYMVYYNFFAFVLVPLLLMLGIYLRIFLAARRQESQGERTRSTLQKEVHPAKSLAIIVGLFALCCLPLNIINCFTFFCPECHAPPWLMYLTIILSHGNSVVNPLIYAYRIREFRQTFRKIIRSHILRRRELFKAGGAHSPEGEQVSLR >C3AR_MOUSE --------------MESFDADTNSTDLHSRPLFQPQDIASMVILGLTCLLGLLGNGLVLWVAGVKMK-TTVNTVWFLHLTLADFLCCLSLPFSLAHLILQGHWPYGLFLCKLIPSIIILNMFASVFLLTAISLDRCLIVHKPICQNHRNVRTAFAICGCVWVVAFVMCVPVFVYRDLFI-ED-DYVDQFT-YDNHVPTPLMAITITRLVVGFLVPFFIMVICYSLIVFRM--------RKTNFTKSRNKTFRVAVAVVTVFFICWTPYHLVGVLLLITDPEEAVMSWDHMSIALASANSCFNPFLYALLGKDFRKKARQSIKGILEAAFSEELTHSASS--------- >TA2R_BOVIN --MWPNA-----------SSLGPCFRPMNITLEERRLIASPWFAASFCLVGLASNLLALSVLMGARQSRSSFLTFLCGLVLTDFMGLLVTGAIVVTQHFVLFVDPGCSLCHFMGVIMVFFGLCPLLLGAAMASERFLGITRPFRPATASQRRAWTTVGLVWASALALGLLPLLGVGHYTVQYPGSWCFLT----LGTDPGDVAFGLLFALLGSISVGMSFLLNTISVATLCHVYHGATAQQRPRDCEVEMMVQLMGIMVVASICWMPLLVFIAQTVLQSPPRLTERQLLIYLRVATWNQILDPWVYILFRRAVIQRFYPRLSTRSRSLSLQPQLTR------------ >OPSD_RABIT MNGTEGPDFYIPMSNQTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATASKTETSQVAPA >OPSD_PHOVI MNGTEGPNFYVPFSNKTGVVRSPFEFPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVGFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTLPAFFAKAASIYNPVIYIMMNKQFRTCMITTLCCGKNPLGDDEVSASASKTETSQVAPA >D3DR_RAT --------MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN---D-P--SICSI---------SNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRTSLPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC------------------------- >DADR_.ENLA ---------------MTFNITSMDEDVLLTERESSFRVLTGCFLSVLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-TFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKVAFIMIGVAWTLSVLISFIPVQLNWHKALN-TMDNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAAKQLDCESSLKTSFKRETKVLKTLSVIMGVFVCCWLPFFILNCIVPFCDPSCISSTTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSNLLGCYRLCPTSNNIIETAVVYSCQ----- >PAR2_HUMAN ---VDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIF--N--TTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRML------SAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLKSSS-------- >GPRA_RAT TPANQSAEASESNVSATVPRAAAVTPFQSLQLVHQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLTLAYAFEPRWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPL-RRRISLKLSAYAVLGIWALSAVLALPAAVHTYHVEHD--VRLCEEF--WGSQERQRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLRNRPGS-SQADWDRARRRRTFCLLVVVVVVFALCWLPLHIFNLLRDLDPRAYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKMLLSWPRKIVPHGQNMT------------ >ET1R_PIG EFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPKT--HKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPWKNHEQNNHNTE >NTR2_MOUSE -----METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARTRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLARRLLTPRRTCRLLSLVWVASLGLALPMAVIMGQKH--AASRVCTVL---VSRASSRSTFQVKRAGLLRSPLWELTAILNGITVNHLVALVQARHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQSTYSFRLWGSPR >CKR7_MOUSE QDEVTDDYIGENTTVDYTLYESVC---FKKDVRNFKAWFLPLMYSVICFVGLLGNGLVILTYIYFKRLKTMTDTYLLNLAVADILFLLILPFWAYSEAKS--WIFGVYLCKGIFGIYKLSFFSGMLLLLCISIDRYVAIVQAVRHRARVLLISKLSCVGIWMLALFLSIPELLYSGLQK-GE-TLRCSLV---SAQVEALITIQVAQMVFGFLVPMLAMSFCYLIIIRTL---------LQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNKQLNIAYDVTYSLASVRCCVNPFLYAFIGVKFRSDLFKLFKDLGCLSQERLRHWS--------HVRN >NY5R_HUMAN -------------NTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVESS--RYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGVHEKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM---------------------- >VG74_HSVSA VKLDFSSEDFSNYSYNYSGDIYYGDVAPCVVNFLISESALAFIYVLMFLCNAIGNSLVLRTFLKYRA-QAQSFDYLMMGFCLNSLFLAGYLLMRLLRMFE--IFMNTELCKLEAFFLNLSIYWSPFILVFISVLRCLLIFCATRLWVKKTLIGQVFLCCSFVLACFGALPHVMVTSYYE----PSSCIEE---VLTEQLRTKLNTFHTWYSFAGPLFITVICYSMSCYKL---------FKTKLSKRAEVVTIITMTTLLFIVFCIPYYIMESIDTLLRVGSAIVYGIQCTYMLLVLYYCMLPLMFAMFGSLFRQRMAAWCKTICHC--------------------- >CCKR_HUMAN DSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTANMCRFL---LPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGRANSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVTTGASLSRFSYS >OPSR_CARAU GD--ETTRESMFVYTNSNNTRDPFEGPNYHIAPRWVYNLATVWMFFVVVASTFTNGLVLVATAKFKKLRHPLNWILVNLAVADLAETLLASTISVTNQFFGYFILGHPMCIFEGFTVSVCGIAGLWSLTVISWERWVVVCKPFGNVKFDAKWASAGIIFSWVWSAIWCAPPIFGWSRFWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIILCYIAVWLAIRTVAQQQKDSESTQKAEKEVSRMVVVMIFAYCFCWGPYTFCACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQFRVCIMQLFGKKVDDG-----SEVSS------VAPA >OPS2_LIMPO PN-----ASVVDTMPKEMLYMIHEHWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFMMPTMASNCFAETWILGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAAPLTHKKATLLLLFVWIWSGGWTILPFFGWSRYVPEGNLTSCTVD--YLTKDWSSASYVIIYGLAVYFLPLITMIYCYFFIVHAVAEHNVAANADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIIAWAGVFSSGTRLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLACGSGESGSDVKTMEEKPKSPEA- >O5I1_HUMAN -----------MEFTDRNYTLVTEFILLGFPTRPELQIVLFLMFLTLYAIILIGNIGLMLLIRIDPHLQTPMYFFLSNLSFVDLCYFSDIVPKMLVNFLSENKSISYYGCALQFYFFCTFADTESFILAAMAYDRYVAICNPLYTVVMSRGICMRLIVLSYLGGNMSSLVHTSFAFIL---KNHFFCDLPKLSCTDTTINEWLLSTYGSSVEIICFIIIIISYFFILLSV--------LKIRSFSGRKKTFSTCASHLTSVTIYQGTLLFIYSRPSYLY---SPNTDKIISVFYTIFIPVLNPLIYSLRNKDVKDAAEKVLRSKVDSS-------------------- >OAR_HELVI --TEEVIEDDRDACAVADDPKYPSSFGITLAVPEWEAICTAIVLTLIIISTIVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPIYAQKRTLERVLLMIGVVWVLSLIISSPPLLGWNDW-E-P--TPCRLT--------SQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRAVYEEKQRISLTRERRAARTLGIIMGVFVVCWLPFFVIYLVIPFCASCCLSNKFINFITWLGYCNSALNPLIYTIFNMDFRRAFKKLLCMKP----------------------- >O1D4_HUMAN -------------MDGDNQSENSQFLLLGISESPEQQQILFWMFLSMYLVTVLGNVLIILAISSDSHLHTPMYFFLANLSFTDLFFVTNTIPKMLVNFQSQNKAISYAGCLTQLYFLVSLVTLDNLILAVMAYDRYVAICCPLYVTAMSPGLCVLLLSLCWGLSVLYGLLLTFLLTRV---THYLFCDMYWLACSNTHIIHTALIATGWFIFLTLLGFMTTSYVRIVRTI--------LQMPSASKKYKTFSTCASHLGVVSLFYGTLAMVYLQPLHTY----SMKDSVATVMYAVLTPMMNPFIYSLRNKDMHGAPGRVLWRPFQRP-------------------- >OPSD_APIME AR-F-NNQTVVDKVPPDMLHLIDANWYQYPPLNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNFLMMFCMSPPMVINCYYETWVLGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSGKPLSINGALIRIIAIWLFSLGWTIAPMFGWNRYVPEGNMTACGTD--YFNRGLLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHMNVRSSENQNTSAECKLAKVALMTISLWFMAWTPYLVINFSGIFNLVK-ISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFAKFPSLACAAEPSSDAVSVTDNEKSNA--- >TRFR_CHICK ----------MENGTGDEQNHTGLLLSSQEFVTAEYQVVTILLVLLICGLGIVGNIMVVLVVLRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITESLYKSWVYGYVGCLCITYLQYLGINASSFSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWSFASVYCMLWFFLLDLN--DT-VVSCGYK------RSYYSPIYMMDFGIFYVLPMVLATVLYGLIARILFLNVNSNKSFNSTIASRRQVTKMLAVVVVLFAFLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCHLKRDKKPANYSVKESDHFSSEIED >OPSR_HUMAN DSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDG-----SELVSSV--SSVSPA >CB2R_MOUSE ----MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHG-VDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPYKALVTRGRALVALCVMWVLSALISYLPLMGWTC-----CPSPCSEL------FPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHAEHQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKVTETEADVKTT- >PE21_HUMAN --MSPCGPLNLSLAGEATTCAA---PWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGSATTFLLFVASLLATDLAGHVIPGALVLRLYTAG-RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIG--LGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALHRSRRRAHGPRRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLSSLRSSRHSGLS >OPR._CAVPO GSHLQGNLSLLSPNHSGLPPHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQATDILLGF-WPFGNTLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALALVVGVPVAIMGSAQVEE---IECLVE-IPDPQDYWGPVFAVSIFLFSFIIPVLIISVCYSLMIRRLHGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETTVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVALGCKTTETVPR >OPSV_CHICK -----MSSDDDFYLFTNGSVPGPWDGPQYHIAPPWAFYLQTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHGGLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWSRYMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRAVAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQFRACIMETVCGKPLTD--DSDASTSSVSSSQVGPT- >YKR5_CAEEL MNSENGLDSVTQIMYDMKKYNIVNDVLPPPNHEDLHVVIMAVSYLLLFLLGTCGNVAVLTTIYHVIRTLDNTLIYVIVLSCVDFGVCLSLPITVIDQILGF-WMFGKIPCKLHAVFENFGKILSALILTAMSFDRYAGVC---------HPQRKRLRSRNFAITILLAPGMLTRM-------KIEKCTVD----IDSQMFTAFTIYQFILCYCTPLVLIAFFYTKLLSKLRE----TRTFKSSQIPFLHISLYTLAVACFYFLCWTPFWMATLFAVYLENSPVFVYIMYFIHALPFTNSAINWILYGRVFLETVS--------------------------------- >5H1B_MOUSE CAPPPPAASQTGVPLTNLSHNSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPKRAAIMIVLVWVFSISISLPPFFWR----E-E--LDCFVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG--------------------- >P2YR_HUMAN AAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTG----KTITCYDT-TSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLPEFKQNGDTSL >5H4_CAVPO ------------------MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIRK-NSTYCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHGRPDQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT-VPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTINGSTHVLR-- >MC4R_PIG GMHTSLHFWNRSTYGLHSNASEPLGKGYSEGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALYHNIMTVKRVGIIISCIWAVCTVSGVLFIIYYS----------------------DDSSAVIICLITVFFTMLALMASLYVHMFLMARLH-RIPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY------------ >SSR1_MOUSE GEGACSRGPGSGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAADG--TVACNML-MPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQ--DDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLS-----WMDNAAETALKSRAYSVED >CML1_HUMAN EDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN-SS--WPTHSQ-MDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------HRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK-FKVALFSRLVNALSEDTGHSFTKMSSMNERTS >ACM1_RAT ------------MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >MRG_HUMAN QNPNLVSQLCGVFLQNETNETIHMQMSMAVGQQALPLNIIAPKAVLVSLCGVLLNGTVFWLLCCGAT--NPYMVYILHLVAADVIYLCCSAVGFLQVTLLTYHGVVFFIPDFLAILSPFSFEVCLCLLVAISTERCVCVLFPIYRCHRPKYTSNVVCTLIWGLPFCINIVKSLFLTYWK-------------------KACVIFLKLSGLFHAILSLVMCVSSLTLLIRFL--------CCSQQQKATRVYAVVQISAPMFLLWALPLSVAPLITDF----KMFVTTSYLISLFLIINSSANPIIYFFVGSLRKKRLKESLRVILQRALADKPEVGIDPMEQPHSTQH >A2AC_RAT AEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ----------------- >OPSD_SEPOF ---MGRDIPDNETWWYNPTMEVHPHWKQFNQVPDAVYYSLGIFIGICGIIGCTGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFIKWVFGMAACKVYGFIGGIFGLMSIMTMSMISIDRYNVIGRPMASKKMSHRRAFLMIIFVWMWSTLWSIGPIFGWGAYVLEGVLCNCSFD--YITRDSATRSNIVCMYIFAFCFPILIIFFCYFNIVMAVSNHRLNLRKAQAGASAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPLIYSVSHPKFREAIAENFPWIITCCQFDEKEVEEIPATEQS-GGE >SSR3_HUMAN SVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR-----STCHMQ-WPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSARVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGEDEEEEDG---E >O.1R_HUMAN MGVPPGSREPSPVPPDYED-EFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSRTRLFSVCDER---WADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQPRFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKASHKS---LSLQS >O2C1_HUMAN -------------MDGVNDSSLQGFVLMSISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSRLEARLHTPMYFFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAFDRYVAVCRPLYTAIMNPQLCWLLAVIAWLGGLGNSVIQSTFTLQL---PEGFLCEVPKLACGDTSLNQAVLNGVCTFFTAVPLSIIVISYCLIAQAV--------LKIHSAEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPAKNS---KQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGALRRLLGKGREVG-------------------- >OPSD_MOUSE MNGTEGPNFYVPFSNVTGVGRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLCCGKNPLGDDDASATASKTETSQVAPA >CB1R_TARGR EFFNRSVSTFKENDDNLKCGENFMDMECFMILTASQQLIIAVLSLTLGTFTVLENFLVLCVILQSRTRCRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHR-KDSSNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRTKAVIAFCVMWTIAIIIAVLPLLGWNCK-K--LKSVCSDI------FPLIDENYLMFWIGVTSILLLFIVYAYVYILWKAHSHSEDQITRPEQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNNPIKTVFAFCSMLCLMDSTVNPIIYALRSQDLRHAFLEQCPPCEGTSQPLDNSMEGNN-AGNVHRAA >B2AR_HUMAN MGQPGNGSAFLLAPNRSHAPDH----DVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQGRTLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IRKEVYILLNWIGYVNSGFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGYSGNTGEQSGYHVE >OPSD_ZOSOP MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYACLGAYMFFLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFCIPLAVVGFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVIGFLVCWLPYASVAWYIFTHQGSEFGPPFMTVPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTVSSSSVSPAA-- >GP37_HUMAN LAQNGSLGEGIHEPGGPRRGNRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKI-K--KISPDLTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKATRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTYTTELELSPFST >OPSR_CHICK HEEEDTTRDSVFTYTNSNNTRGPFEGPNYHIAPRWVYNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDG-----SEVVSSVSNSSVSPA >IL8B_BOVIN EGFEDEFGNYSGTPPTEDYDYSPC----EISTETLNKYAVVVIDALVFLLSLLGNSLVMLVILYSRIGRSVTDVYLLNLAMADLLFAMTLPIWTASKAKG--WVFGTPLCKVVSLLKEVNFYSGILLLACISMDRYLAIVHATRTLTQKWHWVKFICLGIWALSVILALPIFIFREAYQ-YS-DLVCYED-LGANTTKWRMIMRVLPQTFGFLLPLLVMLFCYGFTLRTL---------FSAQMGHKHRAMRVIFAVVLVFLLCWLPYNLVLIADTLMRAHNDIGRALDATEILGFLHSCLNPLIYVFIGQKFRHGLLKIMAIHGLISKEFLAKDG------------ >OPSD_MACFA MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNAEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLFGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEARAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSASIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA >5H2B_RAT ILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEA-NA---ITCELT------KDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKRRMGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKGNSMVENSKFFT >OPSR_ANOCA NDEDDTTRDSLFTYTNSNNTRGPFEGPNYHIAPRWVYNITSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTCGISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWSRYWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRAVAAQQKESESTQKAEKEVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIMQLFGKKVDDG-----SELVSSVSNSSVSPA >5H1A_MOUSE -MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRA---NP--NECTIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRKNEEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR--------------------- >CCR4_HUMAN IYTSDNYTEEMG-SGDYDSMKEPC---FREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >CKR3_MACMU MTTSLDTVETFGPTSYDDDMGLLC---EKADVGALIAQFVPPLYSLVFMVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRERN-WVFSHGMCKVLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIVTWGLAVLAALPEFIFYGTEK-LF-KTLCSAIYPQDTVYSWRHFHTLKMTILCLALPLLVMAICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILISTYQSVLKHLDLFVLATEVIAYSHCCVNPVIYAFVGERFRKYLRHFFHRHVLMHLGKYIPFLT-------SSVS >OPSD_GLOME MNGTEGLNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYIPLNLAVANLFMVFGGFTTTLYTSLHAYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWVMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTSRQEVNNESFVIYMFVVHFTIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFTHQGSDFGPIFMTIPSFFAKSSSIYNPVIYIMMNKQLRNCMLTTLCCGRNPLGDDEASTTASKTETSQVAPA >FMLR_MOUSE ---MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMK-HTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPSPWPVEKRKVA------VTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKI---------HRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVREPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTGT---------- >OPSD_LAMJA MNGTEGDNFYVPFSNKTGLARSPYEYPQYYLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWSRYIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKEAAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTLCCGKNPLGDDESGASVSSVSTSPVSPA >C5AR_CAVPO ---MMVTVSYDYDYNSTFLPDGFVD--NYVERLSFGDLVAVVIMVVVFLVGVPGNALVVWVTACEAR-RHINAIWFLNLAAADLLSCLALPILLVSTVHLNHWYFGDTACKVLPSLILLNMYTSILLLATISADRLLLVLSPICQRFRGGCLAWTACGLAWVLALLLSSPSFLYRRTHN-SF--VYCVTD-YG-RDISKERAVALVRLLVGFIVPLITLTACYTFLLLRT---------WSRKATRSAKTVKVVVAVVSSFFVFWLPYQVTGILLAWHSPNRNTKALDAVCVAFAYINCCINPIIYVVAGHGFQGRLLKSLPSVLRNVLTEESLDKSTVD-------- >P2Y8_.ENLA ATSYPTFLTTPYLPMKLLMNLTNDTEDICVFDEGFKFLLLPVSYSAVFMVGLPLNIAAMWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADKNNWPFGEVLCKLVRFLFYANLYSSILFLTCISVHRYRGVCHPISLRRMNAKHAYVICALVWLSVTLCLVPNLIFVTVS-----NTICHDT-TRPEDFARYVEYSTAIMCLLFGIPCLIIAGCYGLMTRELMKP---SGNQQTLPSYKKRSIKTIIFVMIAFAICFMPFHITRTLYYYARLLNVINVTYKVTRPLASANSCIDPILYFLANDRYRRRLIRTVRRRSSVPNRRCMHTNMTAGPLPVISAE >5H1D_FUGRU ELDNNSLDYFSSNFTDIPSN--TTVAHWTEATLLGLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLAVTDMLVSILVMPISIVYTVSKTWSLGQIVCDIWLSSDITFCTASILHLCVIALDRYWAITDALYSKRRTMRRAAVMVAVVWVISISISMPPLFWR----H-E--KECMVN-------TDQISYTLYSTFGAFYVPTVLLIILYGRIYVAARSRKLALERKRLCAARERKATKTLGIILGAFIICWLPFFVVTLVWAICKEC-FDPLLFDVFTWLGYLNSLINPVIYTVFNDEFKQAFQKLIKFRR----------------------- >5HT_LYMST TGQFINGSHSSRSRDNASANDTDDRYWSLTVYSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVLVMPLSVVSEISKVWFLHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTSI-YIRRRSARRILLMIMVVWIVALFISIPPLFGWRD-PD-K--GTCIIS--------QDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRNDTRTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPFVDPEGIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQKILFGKYRRGHR------------------ >5H6_HUMAN -----------MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPARNTS-NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH---E-VPGQCRLL--------ASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQVESRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASSGPRPG-LSLQQ >AG2R_MERUN ------MALNSSADDGIKRIQDDC---PKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPVWAVYTAMEYRWPFGNHLCKIASAGISFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCVVIWLLAGLASLPAVIHRNVYF-TN--TVCAFH-YESQNSTLPVGLGLTKNILGFMFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFRIIMAIVLFFFFSWIPHQIFTFLDVLIQLGDVVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------N >GRHR_HORSE --MANSDSLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPL-AVQSNSKLEQSMISLAWILSIVFAGPQLYIFRMIYTV--FSQCVTH--SFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVPRKNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >REIS_TODPA ---------------------MFGNPAMTGLHQFTMWEHYFTGSIYLVLGCVVFSLCGMCIIFLARQKPRRKYAILIHVLITAMAVNGGDPAHASSSIVGR-WLYGSVGCQLMGFWGFFGGMSHIWMLFAFAMERYMAVCHREFYQQMPSVYYSIIVGLMYTFGTFWATMPLLGWASYGLEVHGTSCTIN--YSVSDESYQSYVFFLAIFSFIFPMVSGWYAISKAWSGLSAIPD-EKEKDKDILSEEQLTALAGAFILISLISWSGFGYVAIYSALTHGGQLSHLRGHVPPIMSKTGCALFPLLIFLLTARSLPKSDTKKP-------------------------- >GRPR_RAT NCSHLNLEVDPFLSCNNTFNQTLSPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPQT--FISCAPY---HSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSLPVNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNR--SHSMTSFKSTNP-SA >CKR5_MACMU ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >B4AR_MELGA --------------MTPLPAGNGSVPNCSWAAVLSRQWAVGAALSITILVIVAGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLSGHWPYGTVVCELWTSLDVLCVTASIETLCAIAVDRYLAITAPLYEALVTKGRAWAVVCMVWAISAFISFLPIMNHWWRDV-R--RCCDFV--------TNMTYAIVSSTVSFYVPLLVMIFVYVRVFAVATRHSRGRRPSRLLAIKEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRPL-VPDQLFLFLNWLGYVNSAFNPIIYCRSP-DFRSAFRKLLCCPRRADRRLHAAPQAFSPRGDPMEDS >OPSV_.ENLA -----MLEEEDFYLFKNVSNVSPFDGPQYHIAPKWAFTLQAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLTGLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWSRYMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRAVAAQQQESASTQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQFRGCIMETVCGRPMSD--DSSVSSSTVSSSQVSPA- >OPSG_ORYLA ENGTEGKNFYIPMNNRTGLVRSPYEYPQYYLADPWQFKLLGIYMFFLILTGFPINALTLVVTAQNKKLRQPLNFILVNLAVAGLIMVCFGFTVCIYSCMVGYFSLGPLGCTIEGFMATLGGQVSLWSLVVLAIERYIVVCKPMGSFKFTATHSAAGCAFTWIMASSCAVPPLVGWSRYIPEGIQVSCGPDYYTLAPGFNNESFVMYMFSCHFCVPVFTIFFTYGSLVMTVKAAAAQQQDSASTQKAEKEVTRMCFLMVLGFLLAWVPYASYAAWIFFNRGAAFSAMSMAIPSFFSKSSALFNPIIYILLNKQFRNCMLATIGMGG-----------VSTSKTEVSTAA >NY6R_RABIT --MEVSLNDPASNKTSAKSNSSAFFYFESCQSPSLALLLLLIAYTVVLIMGICGNLSLITIIFKKQRAQNVTNILIANLSLSDILVCVMCIPFTAIYTLMDRWIFGNTMCKLTSYVQSVSISVSIFSLVLIAIERYQLIVNPR-GWKPSASHAYWGIMLIWLFSLLLSIPLLLSYHLTDSH--HVVCVEH---WPSKTNQLLYSTSLIMLQYFVPLGFMFICYLKIVICLHKRNSKRRENESRLTENKRINTMLISIVVTFAACWLPLNTFNVIFDWYHEVCHHDLVFAICHLVAMVSTCINPLFYGFLNRNFQKDLVVLIHHCLCFALRERY---TLHTDESKGSLR >CCR4_BOVIN IFTSDNYTEDDLGSGDYDSMKEPC---FREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVAN--WYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQKPRKLLAEKVVYVGVWLPAVLLTIPDLIFADIKE-DE-RYICDRF---YPSDLWLVVFQFQHIVVGLLLPGIVILSCYCIIISKL---------SHSKGYQKRKALKTTVILILTFFACWLPYYIGISIDSFILLESTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >OPS2_SCHGR YESSVGLPLLGWNVPTEHLDLVHPHWRSFQVPNKYWHFGLAFVYFMLMCMSSLGNGIVLWIYATTKSIRTPSNMFIVNLALFDVLMLLEMPMLVVSSLFYQR-PVWELGCDIYAALGSVAGIGSAINNAAIAFDRYRTISCPI-DGRLTQGQVLALIAGTWVWTLPFTLMPLLRIWSRFAEGFLTTCSFD--YLTDDEDTKVFVGCIFAWSYAFPLCLICCFYYRLIGAVREHNVKSNADTEAQSAEIRIAKVALTIFFLFLCSWTPYAVVAMIGAFGNRAALTPLSTMIPAVTAKIVSCIDPWVYAINHPRFRAEVQKRMKWLHLGEDARSSKSDRTVGNVSASA-- >DADR_HUMAN --------------MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-TIDNCDSS--------LSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPATNNAIETAAMFSSH----- >THRR_HUMAN LTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMSLSWRTLGRASFTCLAIWALAIAGVVPLVLKEQTIQ--N--TTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCL------SSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHEAAYFAYLLCVCVSSISSCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGDTCS-------- >V2R_HUMAN MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNSG--VTDCWAC---FAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASGRRPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA-LEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDSSLAKDTSS--- >GALR_HUMAN ----MELAVGNLSEGNASCPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLF-SN--QTFCWEQ---WPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLK--NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKEPPSTNCTHV--- >5H7_RAT SSWMPHLLSGFLEVTASPAPTNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSSRLERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERSEFVLQ >UL33_RCMVM ----MDVLLGTEELEDELHQLHFNYTCVPSLGLSVARDAETAVNFLIVLVGGPMNFLVLATQMLSNRSVSTPTLYMTNLYLANLLTVATLPFLMLSNRGL--VGSSPEGCKIAALAYYATCTAGFATLMLIAINRYR-VIHQRRSGAGSKRQTYAVLAVTWLASLMCASPAPLYATVMAA-DAFETCIIYSYDQVK-TVLATFKILITMIWGITPVVMMSWFYVFFYRRL---------KLTSYRRRSQTLTFVTTLMLSFLVVQTPFVAIMSYDSYGVLNNKRDAVSMLARVVPNFHCLLNPVLYAFLGRDFNKRFILCISGKLFSRRRALRERAGPVCALP---SK >O.YR_MOUSE GTPAANWSIELDLGSGVPPGAEGNLTAGPPRRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASVPQVHIFSLRE----VFDCWAV---FIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSARYLKGSRPGENSSTFVLSRCSS >PF2R_RAT --MSINS---------SKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSNSLAIAILMKAYQSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKFDQSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLHSTKITSKHVKMILSGVCMFAVFVALLPILGHRDYQIQASRTWCFYN--TEHIEDWEDRFYLLFFSSLGLLALGISFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAINGNNPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELKVAAISESPAA >D1DR_FUGRU --------------MAQNFSTVGDGKQMLLERDSSKRVLTGCFLSLLIFTTLLGNTLVCVAVTKFRHRSKVTNFFVISLAISDLLVAILVMPWKAATEIMGFWPFG-EFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKVACLMISVAWTLSVLISFIPVQLNWHKALN-PPDNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQSLSECSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCEADCISSTTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSILLGCHRLCPGNS-AIEIAPLSNPSCQYQP >CKR2_RAT HSLFPRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANE--WVFGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSEQ-ED-QHTCGPY----FPTIWKNFQTIMRNILSLILPLLVMVICYSGILHTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQEFLMHLDQAMQVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFRKHIAKNLCKQCPVFVSSTFTPSTGEQ >OPRK_HUMAN PPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVDVD-VIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVAYLRDIDGMNKP >ACM3_BOVIN N---------ISRAAGNLSSPNGTTSDPLGGHTIWQVVFIAFLTGVLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFILWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRNTFKMLLLCQCDKRKRRKQQYQHKRVPEQAL--- >C3.1_HUMAN ---MDQFPESVTENFEYDDLAEAC---YIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKG--LHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAASMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKE-----NECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTL---------FSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDRSRHGSVLSSNF >5H4_HUMAN ------------------MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIRK-NSTYCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHSRPDQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTINGSTHVLRDA >5H2A_PIG NTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEREPGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILAYKSSQLQTGQK >OPSD_DIPVU MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMALACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFSIPLLVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVIAFLVCWLPYASVAWWIFTHQGSDFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >HH1R_HUMAN ----------MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFM--VR-EDKCETD------FYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHLRSQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNC-CNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS----------------------- >OPSD_DELDE MNGTEGLNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVANLFMVFGGFTTTLYTSLHAYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWIMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTLSPEVNNESFVIYMFVVHFTIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFTHQGSDFGPIFMTIPSFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGRNPLGDDEASTTASKTETSQVAPA >OPS1_DROME PLS---NGSVVDKVTPDMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNLTSCGID--YLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHMNVRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGKSSDSEAESKA----- >RGR_BOVIN ---------------------MAESGTLPTGFGELEVLAVGTVLLVEALSGLSLNILTILSFCKTPELRTPSHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSEGCQAHGFQGFVTALASICSSAAVAWGRYHHFCTRS---RLDWNTAVSLVFFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLD--YSRGDRNFTSFLFTMAFFNFLLPLFITVVSYRLME--------------QKLGKTSRPPVNTVLPARTLLLGWGPYALLYLYATIADATSISPKLQMVPALIAKAVPTVNAMNYALGSEMVHRGIWQCLSPQRREHSREQ---------------- >VU51_HSV6U ----------------MEKETKSLAWPATAEFYGWVFIFSSIQLCTMVLLTVRFNSFKVGR-E--------YAVFTFAGMSFNCFLLPIKMGLLSGH-----WSLPRDFCAILLYIDDFSIYFSSWSLVFMAIERINHFCYSTLLNENSKALAKVCFPIVWIISGVQALQMLNNYKATA---ETPQCFLA--------FRSGYDMWLMLVYSVMIPVMLVFIYIYSKNFM-----------LLKDELSTVTTYLCIYLLLGTIAHLPKAGLSEIESD----KIFYGLRDIFMALPVLKVYYIPVMAYCMACDDHTVPVRLCSIWLVNLCKKCFSCTLEVGIKMLK--- >A1AA_ORYLA -----------MTPSSVTLNCSNCSHVLAPELNTVKAVVLGMVLGIFILFGVIGNILVILSVVCHRHLQTVTYYFIVNLAVADLLLSSTVLPFSAIFEILDRWVFGRVFCNIWAAVDVLCCTASIMSLCVISVDRYIGVSYPLYPAIMTKRRALLAVMLLWVLSVIISIGPLFGWKEP--AP--TVCKIT--------EEPGYAIFSAVGSFYLPLAIILAMYCRVYVVAQKELRSFALRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVLPIGSIFPAYRPSDTVFKITFWLGYFNSCINPIIYLCSNQEFKKAFQSLLGVHCLRMTPRAHHHHTQGHSLT----- >B1AR_BOVIN VPDGAATAARLLVPASPPASLLTSASEGPPLPSQQWTAGMGLLMAFIVLLIVVGNVLVLVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPIFMQWWGDS-R--ECCDFI--------INEGYAITSSVVSFYVPLCIMAFVYLRVFREAQKQPGRRRPPRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACGSHAAAGCLAVARPSPSPG >OPSH_ASTFA NE--DTTRESAFVYTNANNTRDPFEGPNYHIAPRWVYNVSSLWMIFVVIASVFTNGLVIVATAKFKKLRHPLNWILVNLAIADLGETVLASTISVINQIFGYFILGHPMCVFEGWTVSVCGITALWSLTIISWERWVVVCKPFGNVKFDGKWAAGGIIFSWVWAIIWCTPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVASYMITLMLTCCILPLSIIIICYIFVWSAIHQVAQQQKDSESTQKAEKEVSRMVVVMILAFIVCWGPYASFATFSAVNPGYAWHPLAAAMPAYFAKSATIYNPIIYVFMNRQFRSCIMQLFGKKVEDA-----SEVSTAS-------- >OL15_MOUSE -------------MEVDSNSSSGTFILMGVSDHPHLEIIFFAVILASYLLTLVGNLTIILLSRLDARLHTPMYFFLSNLSSLDLAFTTSSVPQMLKNLWGPDKTISYGGCVTQLYVFLWLGATECILLVVMAFDRYVAVCRPLYMTVMNPRLCWGLAAISWLGGLGNSVIQSTFTLQL---PDNFLCEVPKLACGDTSLNEAVLNGVCTFFTVVPVSVILVSYCFIAQAV--------MKIRSVEGRRKAFNTCVSHLVVVFLFYGSAIYGYLLPAKSS---NQSQGKFISLFYSVVTPMVNPLIYTLRNKEVKGALGRLLGKGRGAS-------------------- >ETBR_HUMAN SLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITRI--LRICLLHQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFE-EKQSLEFKANDHGYDNFR >PE23_MOUSE ---------MASMWAPEHSAEAHSNLS---STTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHYASHMKTRAT-PVLLGVWLSVLAFALLPVLGVG----RYSGTWCFISNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTN-YASSSTSLPCWSDQLER----- >TA2R_MOUSE --MWPNG-----------TSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLTDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLT----LGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQ------------ >ACM3_HUMAN N---------VSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQHKRAPEQAL--- >CCR4_FELCA IYPSDNYTEDDLGSGDYDSMKEPC---FREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVAN--WYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVRE-DG-RYICDRF---YPSDSWLVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGYQKRKALKTTVILILAFFACWLPYYIGISIDSFILLESTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >GPRJ_MOUSE AEAAEALLPHGLMGLHEEHSWMSNRTELQYELNPGEVATASIFFGALWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVVLQFTTGRWTLGSAMCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPL-SFKVSREKAKKMIAASWILDAAFVTPVFFFYG---SNW-HCNYFLP-----PSWEGTAYTVIHFLVGFVIPSILIILFYQKVIKYIWRIDGR-RTMNIVPRTKVKTVKMFLLLNLVFLFSWLPFHVAQLWHPHEQDYKKSSLVFTAVTWVSFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTIKRNYVGISEIPP >AA2B_MOUSE ------------------------------MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLG--FCTDFHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDI-A-PLTCLFE-----NVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQ---MDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQAETKGGSGLSLGL------- >MAS_HUMAN -----MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMR-RNPFTVYITHLSIADISLLFCIFILSIDYALDYESSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIYRCHRPKYQSALVCALLWALSCLVTTMEYVMCI-DRHS--RNDC-----------RAVIIFIAILSFLVFTPLMLVSSTILVVKIRK----------NTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYW--STFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRTVTVETVV---- >TSHR_SHEEP LQAFDNHYDYTVCGGSEEMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNP------HYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGSTGIRVQKVPPD >NK2R_BOVIN ----MGACVVMTDINISSGLDSNATGITAFSMPGWQLALWTAAYLALVLVAVMGNATVIWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPGTRAVIAGIWLVALALAFPQCFYST---GA---TKCVVAWPEDSGGKMLLLYHLIVIALIYFLPLVVMFVAYSVIGLTLWRRGHQHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGTFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----YTPSLSTRVNRC >5H2C_MOUSE LLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAVRSPVHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD-VF--NTTCVL---------NDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQKKKPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKAKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIALSGRELNVNIY >OLF1_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIALISVDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERKTISYVGCILQYFSFVLLTVTESLLLAVMAYDRYVAICKPLYPSIMTKAVCWRLVESLYFLAFLNSLVHTSGLLKL---SNHFFCDISQISSSSIAISELLVIISGSLFVMSSIIIILISYVFIILTV--------VMIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRLTATTFGFIDSKAVQ-------------- >O.2R_RAT ASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL-MFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSKTTLFTVCDER---WGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRKARVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLG-VHRRQGDRLESRKSLTTQISN >CKR8_MOUSE DYTMEPNVTMT--DYYPDFFTAPC---DAEFLLRGSMLYLAILYCVLFVLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQ--WVFGTAMCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVAIKVRTASVGTALSLTVWLAAVTATIPLMVFYQVAS-ED-MLQCFQF-YEEQSLRWKLFTHFEINALGLLLPFAILLFCYVRILQQL---------RGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHQRLALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKS-CSHIFLYLGRQRQ------LSSN >GPRF_MACNE ----MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPLKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTSKLLAIVSGLQAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFT >MC3R_MOUSE NSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALYHSIMTVRKALTLIGVIWVCCGICGVMFIIYYS----------------------EESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHIAVAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG------------------ >CCR5_RAT DDLYKELAIYSNSTEIPLQDSIFCSTEEGPLLTSFKTIFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLLVFILPFAVAEGSVG--WVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAVAYRRRRLLSIHITCSTIWLAGFLFALPELLFAKVVQ-NE-LPQCIFSQENEAETRAWFASRFLYHTGGFLLPMLVMAWCYVGVVHRL--------LQAQRRPQRQKAVRVAILVTSIFLLCWSPYHIVIFLDTLERLKGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCAG---PASLC--------PGWR >OPSD_LOLFO ---MGRDIPDNETWWYNPYMDIHPHWKQFDQVPAAVYYSLGIFIAICGIIGCVGNGVVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFMKWVFGNAACKVYGLIGGIFGLMSIMTMTMISIDRYNVIGRPMASKKMSHRKAFIMIIFVWIWSTIWAIGPIFGWGAYTLEGVLCNCSFD--YITRDTTTRSNILCMYIFAFMCPIVVIFFCYFNIVMSVSNHRLNLRKAQAGANAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFRERIASNFPWILTCCQYDEKEIEEIPAGEQS-GGE >OPSD_TODPA ----GRDLRDNETWWYNPSIVVHPHWREFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKWIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLEGVLCNCSFD--YISRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHRLNLRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQFDDKETEEIPAGESSDAAP >OPRK_RAT LPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVDVD-VIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVASMRDVGGMNKP >ACM4_RAT ------M-NFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-VP-DNQCFIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR---------------- >SSR3_RAT SVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPR-----STCHMQ-WPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTSCQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGEEDEEEEERREE >OPSD_HUMAN MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA >OPSG_GECGE RDDDDTTRGSVFTYTNTNNTRGPFEGPNYHIAPRWVYNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDLVETLVASTISVFNQIFGYFILGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVVCKPFGNIKFDSKLAIIGIVFSWVWAWGWSAPPIFGWSRYWPHGLKTSCGPDVFSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIRAVAAQQKESESTQKAEREVSRMVVVMIVAFCICWGPYASFVSFAAANPGYAFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIMQLFGKKVDDG-----SEAVSSVSNSSVAPA >OAR_BOMMO TEIYDVIEDEKDVCAVADEPNIPCSFGISLAVPEWEAICTAIILTMIIISTVVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPIYAQKRTLERVLFMIGIVWILSLVISSPPLLGWNDW-E-P--TPCRLT--------SQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRAVYEEKQRISLTRERRAARTLGIIMGVFVVCWLPFFVIYLVIPFCVSCCLSNKFINFITWLGYVNSALNPLIYTIFNMDFRRAFKKLLFIKC----------------------- >YQH2_CAEEL EQSTPARENLPNREIYQIFQFTLVYALPLSNHDNSSLMLIAGFYALLFMFGTCGNAAILAVVHHVKGRHNTTLTYICILSIVDFLSMLPIPMTIIDQILGF-WMFDTFACKLFRLLEHIGKIFSTFILVAFSIDRYCAVCHPLQVRVRNQRTVFVFLGIMFFVTCVMLSPILLYAHSKVTRMHLYKCVDD----LGRELFVVFTLYSFVLAYLMPLLFMIYFYYEMLIRLFKQLVGGGEEKKLTIPVGHIAIYTLAICSFHFICWTPYWISILYSLYEELYYAFIYFMYGVHALPYINSASNFILYGLLNRQLHNAPERKYTRNGVGGRQMSHALTSELIAIPSSSCR >UL33_HSV7J ----MICYSFAKNVTFAFLIILQNFFSQHDEEYKYNYTCITPTVRKAQRLESVINGIMLTLILPVSTKQTITSPYLITLFISDSLHSLTVLLLTLNREAL--TNLNQALCQCVLFVYSASCTYSLCMLAVISTIRYR-TLQRRTLNDKNNNHIKRNVGILFLSSAMCAIPAVLYVQVEKK-KNYGKCNIHSTQKAY-DLFIGIKIVYCFLWGIFPTVIFSYFYVIFGKTL---------RALTQSKHNKTLSFISLLILSFLCIQIPNLLVMSVEIFFLYIIQREIVQIISRLMPEIHCLSNPLVYAFTRTDFRLRFYDFIKCNLCNSSLKRKRNP------------ >C5AR_RAT DPISNDSSEITYDYSDGTPNPDMPADGVYIPKMEPGDIAALIIYLAVFLVGVTGNALVVWVTAFEAK-RTVNAIWFLNLAVADLLSCLALPILFTSIVKHNHWPFGDQACIVLPSLILLNMYSSILLLATISADRFLLVFKPICQKFRRPGLAWMACGVTWVLALLLTIPSFVFRRIHK-SD--ILCNID-YSKGPFFIEKAIAILRLMVGFVLPLLTLNICYTFLLIRT---------WSRKATRSTKTLKVVMAVVTCFFVFWLPYQVTGVILAWLPRSQSVERLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLRRSLPSIIRNVLSEDSLGRSTMD-------- >CKR6_HUMAN DSSEDYFVSVNTSYYSVDSEMLLC---SLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGA-WVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYN-TQ-SDVCEPKQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTL---------VQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFEN------ISRQ >B2AR_MOUSE MGPHGNDSDFLLAPNGSRAPDH----DVTQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-D--TCCDFF--------TNQAYAIASSIVSFYVPLCVMVFVYSRVFQVAKRQGRSLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRDNL-IPKEVYILLNWLGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSSKTYGNGYSDYTGEPNTCQLG >DADR_DIDMA ---------------MPLNDTTMDRRGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLNWHKAGN-TMDNCDSS--------LSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCESDCIDSITFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPTANNAIETGAVFSSH----- >O.YR_MACMU GELAANWSTEAVNSSAAPPGAEGNCTAGPPRRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNRMAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANA-KEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGNRLGENSSSFVLSHRSS >AG2R_MELGA ------MVPNYSTEETVKRIHVDC---PVSGRHSYIYIMVPTVYSIIFIIGIFGNSLVVIVIYCYMKLKTVASIFLLNLALADLCFLITLPLWAAYTAMEYQWPFGNCLCKLASAGISFNLYASVFLLTCLSIDRYLAIVHPVSRIRRTMFVARVTCIVIWLLAGVASLPVIIHRNIFF-LN--TVCGFR-YDNNNTTLRVGLGLSKNLLGFLIPFLIILTSYTLIWKTLKKA----YQIQRNKTRNDDIFKMIVAIVFFFFFSWIPHQVFTFLDVLIQLHDIVDTAMPFTICIAYFNNCLNPFFYVFFGKNFKKYFLQLIKYIPPNVSTHPSLTTRPPE-------N >TSHR_MOUSE LQAFESHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSY----KVSICLPM-----TDTPLALAYIVLVLLLNVVAFVVVCSCYVKIYITVRNP------QYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYQGSTGIQIQKIPQD >CCR3_MOUSE FAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQ--WVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATIYRRDPRVRVALTCIVVWGLCLLFALPDFIYLSANY-RL-ATHCQYN----FPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVL---------LVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGSHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREKMWMLFTRLGRSDQRGPQRQPSWSETTEASYLG >AA2B_RAT ------------------------------MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLG--FCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDI-T-PVKCLFE-----NVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQ---MEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGFSLSL------- >MSHR_RANTA PVLGSQRRLLGSLNCTPPATFPLMLAPNRTGPQCLEVSIPNGLFLSLGLVSLVENVLVVAAIAKNSNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHRGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >CKR3_RAT EEELKTVVETFETTPYEYEWAPPC---EKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNE-WGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVALRARTVTFATITSIITWGFAVLAALPEFIFHESQD-NF-DLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTL---------LRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLT-------SSVS >OPS2_HEMSA DFGYPEGVSIVDFVRPEIKPYVHQHWYNYPPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLIMLTTNVPFFTYNCFSGGWMFSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNGPKLTTGKAVVFALISWVIAIGCALPPFFGWGNYILEGILDSCSYD--YLTQDFNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHMNVRSNEADAQRAEIRIAKTALVNVSLWFICWTPYALISLKGVMGDTSGITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAITQHLPWFCVHETETKSNDDAQDKA------- >AG2R_RABIT ------MMLNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTRPSD-------N >5H2A_HUMAN NTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILAYKSSQLQMGQK >AA2A_HUMAN -------------------------------MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGS-Q-QVACLFE-----DVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQESQGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGAHGSDGEQVSLR >HH2R_CAVPO -------------------MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLITPARVAISLVFIWVISITLSFLSIHLGWN--RN-TIVKCKVQ--------VNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQR--IGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDD-VNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRRSQCQEPRW--- >IL8B_HUMAN KGEDLSNYSYSSTLPPFLLDAAPC----EPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVY-NV-SPACYED-MGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDS------------ >OLF5_RAT -------------MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILAIGTDSRLHTPMYFFLSNLSFVDVCFSSTTVPKVLANHILGSQAISFSGCLTQLYFLAVFGNMDNFLLAVMSYDRFVAICHPLYTTKMTRQLCVLLVVGSWVVANMNCLLHILLMARL---SPHFFCDGTKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITCAV--------LRVSSPRGGWKSFSTCGSHLAVVCLFYGTVIAVYFNPSSSH---LAGRDMAAAVMYAVVTPMLNPFIYSLRNSDMKAALRKVLAMRFPSKQ------------------- >OPSB_CHICK TDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSRYIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRAVARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQFRSCMLKLLFCGRSPFGDDEDVSGSSVSSSHVAPA- >AA2A_RAT ----------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCST-K-RVTCLFE-----DVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQESQGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGAHSTEGEQVSLR >OLF6_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIALISIDLQLQTPMYIFLQNLSFTDAVYSTVITPKMLATFLEETKTISYVGCILQYFSFVLLTVRECLLLAVMAYDRYAAICKPLYPAIMTKAVCWRLVKGLYSLAFLNFLVHTSGLLKL---SNHFFCDNSQISSSSTALNELLVFIFGSLFVMSSIITILISYVFIILTV--------VRIRSKERKYKAFSTCTSHLMAVSLFHGTIVFMYFQPANNF---SLDKDKIMSLFYTVVIPMLNPLIYSWRNKEVKDALHRAIATAVLFH-------------------- >P2Y6_HUMAN -----------MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATG-----RTVCYDL-SPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQ---GPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR--------------- >OPS5_DROME SLGDGSVFPMGHGYPAEYQHMVHAHWRGFREAPIYYHAGFYIAFIVLMLSSIFGNGLVIWIFSTSKSLRTPSNLLILNLAIFDLFMCTN-MPHYLINATVGYIVGGDLGCDIYALNGGISGMGASITNAFIAFDRYKTISNPI-DGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYPEGFLTTCSFD--YLTNTDENRLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHNVKANANADNMSVELRIAKAALIIYMLFILAWTPYSVVALIGCFGEQQLITPFVSMLPCLACKSVSCLDPWVYATSHPKYRLELERRLPWLGIREKHATSGTSSVSGDTLALSVQ >YR13_CAEEL --------------------MSNIFSVPLDPMSVAVGIPYVCFFIILSVVGIIGNVIVIYAIAGDRNRKSVMNILLLNLAVADLANLIFTIPEWIPPVFFGSWLFPSFLCPVCRYLECVFLFASISTQMIVCIERYIAIVLPMARQLCSRRNVLITVLVDWIFVACFASPYAVWHSVK-LFQLSATCSNT---VGKSTWWQGYKLTEFLAFYFVPCFIITVVYTKVAKCLWCKCLDSSRSSDALRTRRNVVKMLIACVAVYFVCYSPIQVIFLSKAVLNVTHPPYDFILLMNALAMTCSASNPLLYTLFSQKFRRRLRDVLYCPSDVENETKTYYSGPRASF------ >5H1B_CRIGR CAPPPPAASQTGVPLVNLSHNSAESHIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPVSTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYAAKRTPKRAAIMIALVWVFSISISLPPFFWR----E-E--LTCLVN-------TDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMATLDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG--------------------- >D2DR_BOVIN ---MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC------------------------- >VU51_HSV6Z ----------------MEKETKSLAWPATAEFYGWVFIFSSIQLCTVVFLTVRFNGFKVGR-E--------YAVFTFAGMSFNCFLLPIKMGLLSGH-----WTLPRDFCAILLYIDDFSAYFSSWSLVFMAIERINYFCYSTLLNENSKALAKVCFPIVWVVSGVQALQMLNNYKATA---ETGQCFLA--------FRSGHDMWLMLVYSVVIPVMLVFFYLYSKNFM-----------LLKDELSSVTTYLCIYLLLGTIAHLPKAALSEIESD----KIFYGLRDIFMALPVLKVYYISAMAYCMACDDHTVPVRLCSIWLVNLCKKCFSCTLEVGIKMLK--- >D2DR_MOUSE ---MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC------------------------- >CCR4_MACFA IYTSDNYTEEMG-SGDYDSIKEPC---FREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLYVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALGFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >HH1R_BOVIN ---------MTCPNSSCVFEDKMCQGNKTAPANDAQLTPLVVVLSTISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGVVVMPMNILYLLMSRWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASITILAAWFLSFLWIIPILGWRHFQ--EP-EDKCETD------FYNVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHLRSQYVSGLHMNRERKAAKQLGFIMAAFIICWIPYFIFFMVIAFCESC-CNQHVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS----------------------- >OPS2_DROPS AQTG-GNRSVLDNVLPDMAPLVNPHWSRFAPMDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKIAFIWMMAVFWTIMPLIGWSSYVPEGNLTACSID--YMTRQWNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHMNVRSSEDCDKSAENKLAKVALTTISLWFMAWTPYLIICYFGLFKIDG-LTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLKEKCPMCVCGTTDEPKPDATSEAESKD---- >OPSD_SCYCA MNGTEGENFYIPMSNKTGVVRSPFDYPQYYLAEPWKFSVLAAYMFFLIIAGFPVNFLTLYVTIQHKKLRQPLNYILLNLAVADLFMIFGGFPSTMITSMNGYFVFGPSGCNFEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGSQHAFMGVGLTWIMAMACAFPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFSIPLTIIFFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVIIMVIAFLICWLPYASVAFFIFCNQGSEFGPIFMTIPAFFAKAASLYNPLIYILMNKQFRNCMITTICCGKNPFEEEESTSASSVSSSQVAPAA >OPSD_BUFBU MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSILCAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTVTMYSSMNGYFILGATGCYVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFSENHAVMGVAFTWIMALSCAVPPLLGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVFFLICWVPYASVAFFIFSNQGSEFGPIFMTVPAFFAKSSSIYNPVIYIMLNKQFRNCMITTLCCGKNPFGEDDASSAASSVSSSQVSPA >ACM4_CHICK AQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIV-VH-ERECYIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETC-VPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR---------------- >GRHR_RAT --MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPL-AVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYAV--FSQCVTH--SFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVPRKNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >C5AR_MOUSE ---MNSSFEINYDHY-GTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFEPD-GPSNAIWFLNLAVADLLSCLAMPVLFTTVLNHNYWYFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPICQKVRGTGLAWMACGVAWVLALLLTIPSFVYREAYK-SE--TVCGIN-YGGGSFPKEKAVAILRLMVGFVLPLLTLNICYTFLLLRT---------WSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSKRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRSTDD-------- >5H2A_MACMU NTSDAFNWTVESENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEDPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILAYKSSQLQMGQK >LSHR_BOVIN ESELSGWDYDYGFCLPKTLQCAPEPDAFNPCEDIMGYNFLRVLIWLINILAITGNVTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGWQTG-SGCSAAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLKHAIPVMLGGWLFSTLIAVLPLVGVSNY----KVSICLPM-----VESTLSQVYILTILILNVMAFIIICACYIKIYFAVQNP------ELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFQRDFFLLLSKFGCCKYRAELYRRSNCKNGFTGSNK >SSR5_HUMAN LFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASF-WPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQE-----GTCNAS-WPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGV--RVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEQQQEATRPRTAA >B2AR_PIG MGQPGNRSVFLLAPNGSHAPDQ----DVPQERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGSFWCEFWISIDVLCVTASIETLCVIAVDRYLAITSPFYQCLLTKNKARVVILMVWVVSGLISFLPIKMHWYQAL-N--ACCDFF--------TNQPYAIASSIVSFYLPLVVMVFVYSRVFQVARRQGRSHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHGIHDNL-IPKEVYILLNWVGYVNSAFNPLIYCRSP-DFRMAFQELLCLHRSSLKAYGNGCSDYTGEQSGCYLG >FSHR_RAT SDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNP------TIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTNFHARKSHCSSA >D4DR_MOUSE ---MGNSSATEDGGLLAGRGP---ESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPL-RYNQQGQCQLLLIAATWLLSAAVASPVVCGLN---G-R--AVCCL---------ENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWPEPRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC----------------------- >GALT_MOUSE --------------------MADIQNISLDSPGSVGAVAVPVVFALIFLLGMVGNGLVLAVLLQPGPPGSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLSRALRTPRNARAAVGLVWLLAALFSAPYLSYYG---GA--LELCVPA----WEDARRRALDVATFAAGYLLPVTVVSLAYGRTLCFLWAAGP-AAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAPATYACRLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGHRRHRHHHHRLHPASSGPAGYPGD >AG2R_RAT ------MALNSSAEDGIKRIQDDC---PKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYF-TN--TVCAFH-YESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------N >NMBR_RAT PNLSLPTEASESELEPEVWENDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARSS--FTACIPY---QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSLPGNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKELGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGQKSYPERSTSYLMTSLKSNAKNVV >NY1R_CANFA TSFSQVENHSIFCNFSE-NSQFLAFESDDCHLPLAMIFTLALAYGAVIILGVTGNLALIMIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYVGIAVIWVLAVVSSLPFLIYQVLTDKD--KYVCFDK---FPSDSHRLSYTTLLLMLQYFGPLCFIFICYFKIYIRLKRRNMMMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >A2AD_HUMAN AAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ----------------- >V1AR_SHEEP SSRWWPLDAGDANTSGDLAGLGEDGGPQADTRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLGWDITYRFRGPDGLCRVVKHMQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMVETK--TYDCWAN---FIHPWGLPAYVTWMTGSVFVAPVVILGTCYGFICYHIWRKVLHVSSVKTISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSAWDKNFESENPATAIPALLASLNSCCNPWIYMFFSGHLLQDCAQSFPCCQNVKRTFTREGSTSFTNNRSPTNS >FML1_MOUSE -----------MESNYSIHLNGSEVVVYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMP-HTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRVSWVEERLNTA------ITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKI---------HKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHIAS---------- >OPSD_PETMA MNGTEGENFYIPFSNKTGLARSPFEYPQYYLAEPWKYSVLAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLGGEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWSRYLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKEAAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQFRNCMITTLCCGKNPLGDEDSGASVSSVSTSQVSPA >B2AR_MACMU MGQPGNGSAFLLAPNGSHAPDH----DVTQERDEAWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQGRTLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWVGYVNSGFNPLIYCRSP-DFRIAFQELLCLRRSSLKACGNGYSGNTGEQSGYHLE >AG2R_SHEEP ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFIMIPTLYSIIFVVGLFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASGSVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFHVYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKA----YEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGDIVDTAMPITICLAYFNNCLNPPFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTRPSE-------N >AG2R_BOVIN ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFH-YESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKA----YEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTRPSE-------N >ACM2_HUMAN --------------MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VE-DGECYIQ------FFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >PF2R_HUMAN --MSMNN---------SKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYN--TEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELKVAAISESPVA >US28_HCMVA ----MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDH--NSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMR---YRPVKQACLFSIFWWIFAVIIAIPHFMVVTKK-----DNQCMTD-YDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIV---------AVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKRSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYRSSPSRRETSSD >NK4R_HUMAN NLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHE-WYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATRIVIGSIWILAFLLAFPQCLYSK---GR---TLCYVQ--WPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGG--PCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSY----ATRLHPMRQSSL >MC3R_RAT NSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLLSLLQADMLVSLSNSLETIMIVVINSDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALYHSIMTVRKALSLIVAIWVCCGICGVMFIVYYS----------------------EESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHIAAADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG------------------ >OPS1_HEMSA TFGYPEGMTVADFVPDRVKHMVLDHWYNYPPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIMLTTNFPPFCYNCFSGGWMFSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNGPKLTQGKATFMCGLAWVISVGWSLPPFFGWGSYTLEGILDSCSYD--YFTRDMNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHMNVRSNEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLLGNAEGITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLPWFCVHEKDPNDVEETQEKS------- >AA3R_RAT -----------------------MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLE--VQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWN-RKE-L-TLSCHFR-----SVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNK--NFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVK--IPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSN------------ >SSR4_RAT GED----TTWTPGINASWAPDEEEDAVRSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPGGE-AVACNLH---WPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR-AGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEETALKSRGGPGCI >NK1R_RAT -----MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQGYYST---SR---VVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAS-IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY----STRYLQTQSSVY >OPSD_SARDI MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAILGAYMFFLIIVGFPVNFMTLYVTLEHKKLRTPLNYILLNLAVADLFMVIGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGMISLWSLAVLAIERWVVVCKPISNFRFGENHAIMGVSLTWGMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFFCHFTIPLTIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLVCWLPYASVAWFIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLFCGKNPF---EGEEETEASSASSVSPA >FSHR_HORSE FDMMYSEFEYDLCNEVVDVTCSPKPDAFNPCEDIMGYDILRVLIWFISILAITGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVQLRHAASVMLVGWIFAFAVALLPIFGISTY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNP------NIVSSSSDTKIAKRMAILIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQLYRTISHPRNGHCPPT >OPSG_CARAU MNGTEGKNFYVPMSNRTGLVRSPFEYPQYYLAEPWQFKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSSSHAFAGIAFTWVMALACAAPPLFGWSRYIPEGMQCSCGPDYYTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSASTQKAEREVTKMVILMVFGFLIAWTPYATVAAWIFFNKGADFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIFCGKNPLGDDESS--TSKTEVSSVSPA >AA3R_RABIT ------------------------MPDNSTTLFLAIRASYIVFEIVIGVCAVVGNVLVIWVIKLNPSLKTTTFYFIFSLALADIAVGFLVMPLAIVISLG--ITIGFYSCLVMSCLLLVFTHASIMSLLAIAVDRYLRVKLTVYRRVTTQRRIWLALGLCWVVSLLVGFTPMFGWN-MKE-S-DFQCKFD-----SVIPMEYMVFFSFFTWILIPLLLMCALYVYIFYIIRNK--SFKETGAFYRREFKTAKSLFLVLALFAGCWLPLSIINCVTYFKCK--VPDVVLLVGILLSHANSMMNPIVYACKIQKFKETYLLIFKARVTCQPSDSLDPS------------ >5H1D_HUMAN SPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAATMIAIVWAISICISIPPLFWR----Q-E--SDCLVN-------TSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRKLALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS--------------------- >CCR4_MACMU IYTSDNYTEEMG-SGDYDSIKEPC---FREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQKPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIDILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >OPSP_CHICK ------MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGDFQFQRRHAVSGCAFTWGWALLWSAPPLLGWSSYVPEGLRTSCGPN--WYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLLEMLCCGYQPQRTGKASPGVTAAGLRNKVMP >O7C1_HUMAN -------------METGNQTHAQEFLLLGFSATSEIQFILFGLFLSMYLVTFTGNLLIILAICSDSHLHTPMYFFLSNLSFADLCFTSTTVPKMLLNILTQNKFITYAGCLSQIFFFTSFGCLDNLLLTVMAYDRFVAVCHPLYTVIMNPQLCGLLVLGSWCISVMGSLLETLTVLRL---SPHFFCDLLKLACSDTFINNVVIYFATGVLGVISFTGIFFSYYKIVFSI--------LRISSAGRKHKAFSTCGSHLSVVTLFYGTGFGVYLSSAATP---SSRTSLVASVMYTMVTPMLNPFIYSLRNTDMKRALGRLLSRATFFNGDITAGLS------------ >OPR._PIG GSPLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTAVLLTLPFQGTDVLLGF-WPFGNALCKAVIAIDYYNMFTSAFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASIVGVPVAIMGSAQVEE---IECLVE-IPAPQDYWGPVFAVCIFLFSFVIPVLIISVCYSLMVRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETAVAVLRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCAPTRRREMQVSDRVALACKTSETVPR >OPSD_RAT MNGTEGPNFYVPFSNITGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLCCGKNPLGDDEASATASKTETSQVAPA >P2UR_HUMAN ----MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVLGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTS-----RVTCHDT-SAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKP---YGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLTDMQRIGDVLGS >D1DR_OREMO -MEIFTTTRGTSAGPEPAPGGHGGTDSPR-TSDLSLRALTGCVLCILIVSTLLGNALVCAAVIKFRHRSKVTNAFVISLAVSDLFVAVLVMPWRAVSEVAGVWLFG-AFCDTWVAFDIMCSTASILHLCIISMDRYWAISSPFYERRMTPRFGCVMIGVAWTLSVLISFIPVQLNWHARR--DPGDCNAS--------LNRTYAISSSLISFYIPVLIMVGTYTRIFRIGRTQPALESSLKTSFRRETKVLKTLSVIMGVFVFCWLPFFVLNCMVPFCRLECVSDTTFSVFVWFGWANSSLNPVIYAFNA-DFRKAFSTILGCSRYCRTSAVEAVDYHHDTTLQK--- >OPSP_PETMA HHSLPSALPSATGGNGTVATMHNPFERPLEGIAPWNFTMLAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYFGVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWSSYRPSMIGTTCEPN--WYSGELHDHTFILMFFSTCFIFPLAVIFFSYGKLIQKLKKASETQRGLESTRRAEQQVTRMVVVMILAFLVCWMPYATFSIVVTACPTI---PLLAAVPAFFSKTATVYNPVIYIFMNKQFRDCFVQVLPCKGLKKVSATQTAGASVNTQSPGNRH >DADR_RAT ---------------MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLG-PFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-EDDNCDTR--------LSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSECIDSITFDVFVWFGWANSSLNPIIYAFNA-DFQKAFSTLLGCYRLCPTTNNAIETAVVFSSH----- >GALS_RAT ------------MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLSRELRTPRNALAAIGLIWGLALLFSGPYLSYYR---AN--LTVCHPA----WSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTDP-VTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVHSGSMLEQESTD >5H7_MOUSE SSWMPHLLSGFPEVTASPAPTNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKNVRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMAKMILSVWPLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSSRLERKNISSFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTCLWLGYANSLINPFIYSFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERSEFVLQ >EBI2_HUMAN ------MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMS--KQEERITCMEY--NFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAK-QNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAMTETQMMIHSKS >TSHR_CANFA LQAFDSHYDYTVCGGNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLIVLLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHAYAIMVGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIILVLLLNIVAFIIVCSCYVKIYITVRNP------QYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGSAGIQIQKVTRD >NY4R_RAT HLMASLSPAFLQGKNGTNPLDSLYNLSDGCQDSADLLAFIITTYSVETVLGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPT-GWKPSISQAYLGIVVIWFISCFLSLPFLANSILNDED--KVVCFVS---WSSDHHRLIYTTFLLLFQYCVPLAFILVCYMRIYQRLQRQRA-THTCSSRVGQMKRINGMLMAMVTAFAVLWLPLHVFNTLEDWYQEACHGNLIFLMCHLFAMASTCVNPFIYGFLNINFKKDIKALVLTCRCRPPQGEP---TVHTDLSKGSMR >CKR5_PAPHA ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OLF2_RAT ------------MESGNSTRRFSSFFLLGFTENPQLHFLIFALFLSMYLVTVLGNLLIIMAIITQSHLHTPMYFFLANLSFVDICFTSTTIPKMLVNIYTQSKSITYEDCISQMCVFLVFAELGNFLLAVMAYDRYVA-CHPLYTVIVNHRLCILLLLLSWVISIFHAFIQSLIVLQL---TPHFFCELNQLTCSDNFPSHLIMNLVPVMLAAISFSGILYSYFKIVSSI--------HSISTVQGKYKAFSTCASHLSIVSLFYSTGLGVYVSSAVVQ---SSHSAASASVMYTVVTPMLNPFIYSLRNKDVKRALERLLEGNCKVHHWTG---------------- >HH2R_HUMAN -------------------MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWN--RN-TTSKCKVQ--------VNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQR--ISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDD-INEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRRTQSREPRQ--- >CKR5_HYLLE ----MDYQVSSPTYDIDYDTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILVLINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKHFCKCCSIFA-------SSVY >B3AR_HUMAN MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVQ-R--RCCAFA--------SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPS-VPGPAFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCGRRLPPEPCAAAGVPAARSSPAQP >NY6R_MOUSE --MEVLTNQPTPNKTSGKSNNSAFFYFESCQPPFLAILLLLIAYTVILIMGIFGNLSLIIIIFKKQRAQNVTNILIANLSLSDILVCVMCIPFTVIYTLMDHWVFGNTMCKLTSYVQSVSVSVSIFSLVLIAIERYQLIVNPR-GWKPRVAHAYWGIILIWLISLTLSIPLFLSYHLTNTH--QVACVEI---WPSKLNQLLFSTSLFMLQYFVPLGFILICYLKIVLCLRKRTRQRKENKSRLNENKRVNVMLISIVVTFGACWLPLNIFNVIFDWYHEMCHHDLVFVVCHLIAMVSTCINPLFYGFLNKNFQKDLMMLIHHCWCGEPQESY---TMHTDESKGSLK >OLF4_RAT -------------MTGNNQTLILEFLLLGLPIPSEYHLLFYALFLAMYLTIILGNLLIIVLVRLDSHLHMPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSISYTGCLTQLYFFMVFGDMESFLLVVMAYDRYVAICFPLYTTIMSTKFCASLVLLLWMLTMTHALLHTLLIARL---SLHFFCDISKLSCSDIYVNELMIYILGGLIIIIPFLLIVMSYVRIFFSI--------LKFPSIQDIYKVFSTCGSHLSVVTLFYGTIFGIYLCPSGNN---STVKEIAMAMMYTVVTPMLNPFIYSLRNRDMKRALIRVICTKKISL-------------------- >OPSD_ZEUFA MNGTEGPDFYVPMVNTTGIVRSPYDYPQYYLVNPAAFSMLAAYMFFLILVGFPVNFLTLYVTMEHKKLRTPLNYILLNLAVANLFMVIGGFTTTMYTSMHGYFVLGRTGCNLEGFFATLGGEIALWSLVVLAVERWVVVCKPISNFRFGENHAVMGVSFTWLMACACSVPPLFGWSRYIPEGMQCSCGIDYYTRAPGYNNESFVIYMFVCHFSIPLTIIFFCYGRLLCAVKDAAAAQQESETTQRAEREVSRMVVIMVIGFLICWLPYASVAWFIFTHQGSEFGPVFMTIPAFFAKSSAIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSHVSPA >OPSD_CYPCA MNGTEGPMFYVPMSNATGVVKSPYDYPQYYLVAPWAYGCLAAYMFFLIITGFPINFLTLYVTIEHKKLRTPLNYILLNLAISDLFMVFGGFTTTMYTSLHGYFVFGRIGCNLEGFFATLGGEMGLWSLVVLAFERWMVVCKPVSNFRFGENHAIMGVVFTWFMACTCAVPPLVGWSRYIPEGMQCSCGVDYYTRAPGYNNESFVIYMFLVHFIIPLIVIFFCYGRLVCTVKDAAAQQQESETTQRAEREVTRMVVIMVIGFLICWIPYASVAWYIFTHQGSEFGPVFMTVPAFFAKSAAVYNPCIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >A2AR_LABOS -----MDPLNATGMDAFTAIHLNASWSADSGYSLAAIASIAALVSFLILFTVVGNILVVIAVLTSRALKAPQNLFLVSLATADILVATLVMPFSLANELMGYWYFGKVWCGIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPKRVKCIIVIVWLISAFISSPPLLSIDS--I-S--PQCMLN--------DDTWYILSSSMASFFAPCLIMILVYIRIYQVAKTRKRRIAEKKVSQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLHAVCRDYKIPDTLFK-FFWIGYCNSSLNPAIYTIFNRDFRRAFQKILCKSWKKSF------------------- >D3DR_HUMAN --------MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN---D-P--TVCSI---------SNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRTSLPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------- >D2DR_FUGRU -----MDVFTQYAYNDSIFDNGTWSANETTKDETHPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSRRRVTVMISVVWVLSFAISCPLLFGLN---T-R--SLCFI---------ANPAFVVYSSIVSFYVPFIVTLLVYVQIYVVLRKRQTSLSKRKISQQKEKKATQMLAIVLGVFIICWLPFFITHILNTHCTRCKVPAEMYNAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKILHC------------------------- >P2Y4_HUMAN ASTESSLLRSLGLSPGPGS---SEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTS-----TVLCHDT-TRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQP----LPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLASSCRWAATPQDS >GALR_MOUSE ----MELAMVNLSEGNGSDPEPPAPESRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRSSSLRVSRNALLGVGFIWALSIAMASPVAYHQRLF-SN--QTFCWEQ---WPNKLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLK--NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVVHLWAEFGAFPPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHVCDESPRSETKEPPSTNCTHV--- >OAR1_LOCMI SSAAEEPQDALVGGDACGGRRPPSVLGVRLAVPEWEVAVTAVSLSLIILITIVGNVLVVLSVFTYKPLRIVQNFFIVSLAVADLTVAVLVMPFNVAYSLIQRWVFGIVVCKMWLTCDVLCCTASILNLCAIALDRYWAITDPIYAQKRTLRRVLAMIAGVWLLSGVISSPPLIGWNDW-N-D--TPCQLT--------EEQGYVIYSSLGSFFIPLFIMTIVYVEIFIATKRRPVYEEKQRISLSKERRAARTLGIIMGVFVVCWLPFFLMYVIVPFCNPSKPSPKLVNFITWLGYINSALNPIIYTIFNLDFRRAFKKLLHFKT----------------------- >ML1A_SHEEP GSPGGTPKGNGSSALLNVSQAAPGAGDGVRPRPSWLAATLASILIFTIVVDIVGNLLVVLSVYRNKKLRNAGNVFVVSLAVADLLVAVYPYPLALASIVNNGWSLSSLHCQLSGFLMGLSVIGSVFSITGIAINRYCCICHSLYGKLYSGTNSLCYVFLIWTLTLVAIVPNLCVGT-LQYDP-IYSCTFT------QSVSSAYTIAVVVFHFIVPMLVVVFCYLRIWALVLQVWK-PDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLVVASDPASRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRQEYRKIIVSLCTTKMFFVDSSNRKPSPLIANHNL >OPSD_SOLSO MNGTEGPYFYIPMLNTTGIVRSPYEYPQYYLVNPAAYAALCAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAVERWMVVCKPISNFRFTENHAIMGLGFTWFAASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLICWCPYAGVAWYIFSNQGSEFGPLFMTIPAFFAKSSSIYNPLIYIFMNKQFRHCMITTLCCGKNPFEEEEGSTTSASSSSVSPAA- >ML1A_MOUSE -------MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLHCQVSAFLMGLSVIGSIFNITGIAMNRYCYICHSLYDKIYSNKNSLCYVFLIWMLTLIAIMPNLQTGT-LQYDP-IYSCTFT------QSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVLQVRR-PDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNLIGLIVASDPATRIPEWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKKIIVSLCTAKMFFVESSNCKPSPLIPNNNL >OPSD_POERE MNGTEGPYFYVPMVNTTGIVRSPYEYPQYYLVSPAAYACLGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNLEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFSENHAIMGLVFTWIMANSCAAPPLLGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFICHFCIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIGFLVCWIPYASVAWYIFTHQGSEFGPLFMTVPAFFAKSASIYNPLIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >PE22_HUMAN ----------------MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQLAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYYQRRVSASGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIR--------HGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMGGPRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSS---RKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSSKQADL------ >CKR3_HUMAN MTTSLDTVETFGTTSYYDDVGLLC---EKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEE-LF-ETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLT-------SSVS >GPRA_HUMAN TPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVPRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPL--RRASRCASAYAVLAIWALSAVLALPPAVHTYHVEHD--VRLCEEF--WGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRPGC-SQADWDRARRRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPHAYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMT------------ >OPSD_LIZAU MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILIGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAVERWMVVCKPISNFRFGEDHAIMGLAFTWVMAAACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLVCWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRQCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >PF2R_BOVIN --MSTNS---------SIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYK--TDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELKVAAISDLPVT >GALR_RAT ----MELAPVNLSEGNGSDPEPP-AEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLF-SN--QTFCWEH---WPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLK--NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEPPSTNCTHV--- >OPSU_BRARE MNGTEGPAFYVPMSNATGVVRSPYEYPQYYLVAPWAYGFVAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLGGEMGLKSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWSRYIPEGMQCSCGVDYYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTVKEAARQQQESETTQRAEREVTRMVIIMVIAFLICWLPYAGVAWYIFTHQGSEFGPVFMTLPAFFAKTSAVYNPCIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >GPR6_RAT GPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAG-CGLILHFVFQ-Y--VVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCL-A--DRASCSVV-------RPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHIALHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQ----EDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSP------------ >ACM3_CHICK DSPETTESFPFSTVETTNSSLNATIKDPLGGHAVWQVVLIAFLTGIIALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMGHWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWIISFVLWAPAILFWQYFV-VP-LDECFIQ------FLSEPIITFGTAIAAFYLPVTIMSILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILFAFIITWTPYNIMVLVNTFCDC--VPKTVWNLGYWLCYINSTVNPVCYALCNKMFRNTFKMLLLCQCDKRKRRKQQYQHKRIPREAS--- >NY5R_CANFA -------------NTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMRKRNQKTMVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVESS--RYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGVHDNRSIMRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLISLIQCLHMS--------------------- >MC5R_SHEEP -MNSSFHLHFLDLGLNATEGNLSGLSVRNASSPCEDMGIAVEVFLALGLISLLENILVIGAIVRNRNLHIPMYFFVGSLAVADMLVSLSNFWETITIYLLTNDASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCRLYQRIMTGRRSGAIIAGIWAFCTSCGTVFIVYYY----------------------EESTYVVVCLIAMFLTMLLLMASLYTHMFLLARTH-RIPGHSSVRQRTGVKGAITLAMLLGVFIICWAPFFLHLILMISCPQNSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQGFRTPCRFPSTY------------ >V2R_RAT MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDSG--VFDCWAR---FAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASGRRPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEA-LERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDSSLMKDTPS--- >EDG2_MOUSE QPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIDHCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSNHTILAGVHSND >EDG1_RAT VKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI-S--SLSSCSTV------LPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRLTFISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKEFSRSKSDNSSH >CKR8_HUMAN DYTLDLSVTTVTDYYYPDIFSSPC---DAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQ--WVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVAS-ED-VLQCYSF-YNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQL---------KRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKS-CSQIFNYLGRQKS------SSCQ >B1AR_MACMU LPDGVATAARLLVPASPPASLLPPASEGPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRNAFQRLLCCARRAARRRHAAHGCLARPGPPPSPG >DBDR_.ENLA FQHLDSDQVASWQSPEMLMNKSVSRESQRRKELVAGQIVTGSLLLLLIFWTLFGNILVCTAVMRFRHRSRVTNIFIVSLAVSDLLVALLVMPWKAVAEVAGHWPFG-AFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTQRVALLMISTAWALSVLISFIPVQLSWHKSDH-STGNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQSCSQTSLRTSIKKETKVLKTLSIIMGVFVCCWLPFFILNCMVPFCDRSCVSETTFDIFVWFGWANSSLNPIIYAFNA-DFRKVFSSLLGCGHWCSTTPVETVNYNQDTLFHK--- >O00155 PTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAARRP-WPFGDGLCKLSTFALAGTRSAGALLLAGMSVDRYLAVVKLLARPLRTPRCAVASCCGVWAVALLAGLPSLVYRGLQPLPG-DSQCGE-----EPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRL-------RRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSVFRCRAQAANT >NY4R_HUMAN HLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPT-GWKPSISQAYLGIVLIWVIACVLSLPFLANSILENAD--KVVCTES---WPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEACHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEES---TVHTEVSKGSLR >SSR2_MOUSE QLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTEDGERSDLNETTETQRTLL >EDG2_SHEEP QPQFTAMNEPQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTTVTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIENCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENTSGPTEGSNHTILAGVHSND >5H6_MOUSE -----------MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLYKLRMTAPRALALILGAWSLAALASFLPLLLGWH---E-APGQCRLL--------ASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQMESRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASSGARPGLSLQQV >ACTR_CAVPO -------------MKHIIHASGNVNGTARNNSDCPHVALPEEIFFIISITGVLENLIIILAVIKNKNLQFPMYFFICSLAISDMLGSLYKILESILIMFRNMGSFETTTDDIIDTMFILSLLGSIFSLLAIAVDRYITIFHALYHSIVTMHRTIAVLSIIWTFCIGSGITMVLFFS----------------------HHHVPTVLTFTSLFPLMLVFILCLYVHMFLMARSH---ARNISTLPRGNMRGAITLTILLGVFIFCWAPFILHILLVTFCPNNTCYISLFHVNGMLIMCNAVIDPFIYAFRSPELRSAFRRMISYSKCL--------------------- >OPSD_ALLMI MNGTEGPDFYIPFSNKTGVVRSPFEYPQYYLAEPWKYSALAAYMFMLIILGFPINFLTLYVTVQHKKLRSPLNYILLNLAVADLFMVLGGFTTTLYTSMNGYFVFGVTGCYFEGFFATLGGEVALWCLVVLAIERYIVVCKPMSNFRFGENHAIMGVVFTWIMALTCAAPPLVGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFAIPLAVIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVSFLICWVPYASVAFYIFSNQGSDFGPVFMTIPAFFAKSSAIYNPVIYIVMNKQFRNCMITTLCCGKNPLGDDETATGTSSVSTSQVSPA >OPSD_RANTE MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWKYSILAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTITLYTSLHGYFVFGQSGCYFEGFFATLGGEIALWSLVALAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIITFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWVPYAYVAFYIFCNQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDDDASSAATSVSTSQVSPA >A2AC_CAVPO GPNASGAGEG----GGGVNASGAVWGPPPSQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAIISFPPLVSFYR-------PRCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQLPTPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKHILFRRRRRGFRQ----------------- >PE23_RAT ---------MAGVWAPEHSVEAHSNQS---SAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHYASHMKTRAT-PVLLGVWLSVLAFALLPVLGVG----RYSGTWCFISNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTN-YASSSTSLPCWSDQLER----- >OPSF_ANGAN MNGTEGPNFYVPMSNVTGVVRSPFEYPQYYLAEPWAYSALAAYMFFLIIAGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNIEGFFATLGGEIALWCLVVLAVERWMVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLFGWSRYIPEGMQCSCGMDHYAPNPETYNESFVIYMFICHFTIPLTVISFCYGRLVCTVKEATAQQQESETTQRAEREVTRMVIIMVISFLVCWVPYASVAWYIFTHQGSSFGPIFMTIPAFFAKSSSLYNPLIYICMNKQSRNCMITTLCCGKNPFEEEEGASTASSVSS--VSPA >OPSR_ORYLA NE--DTTRGSAFTYTNSNHTRDPFEGPNYHIAPRWVYNLATLWMFFVVVLSVFTNGLVLVATAKFKKLRHPLNWILSNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSTCGIAALWSLTIISWERWVVVCKPFGNVKFDAKWAIGGIVFSWVWSAVWCAPPVFGWSRYWPHGLKTSCGPDVFSGSDDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRAVAMQQKESESTQKAEREVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQFRTCIMQLFGKQVDDG-----SEVSS------VAPA >CKR5_CERAE ----MDYQVSSPTYDIDNYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPRIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >D2DR_CERAE ---MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC------------------------- >AA3R_SHEEP -------------------------MPVNSTAVSWTSVTYITVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLG--VTIHFYSCLFMTCLMLIFTHASIMSLLAIAVDRYLRVKLTVYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWN-MKA-D-FLPCRFR-----SVMRMDYMVYFSFFLWILVPLVVMCAIYFDIFYIIRNR--SSRETGAFYGREFKTAKSLLLVLFLFALCWLPLSIINCILYFDGQ--VPQTVLYLGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVMCQPSKSMDPS------------ >IL8B_RAT SGDIDSYN-YSSDPPFTLSDAAPC----PSANLDINRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNG--WIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIFILRTTVK-PS-TVVCYEN-IGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEG------------ >NY5R_MOUSE ASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPFPVFHSLVESS--KYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGAQEKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS--------------------- >OPS3_DROPS ARLSAESRLLGWNVPPDELRHIPEHWLIYPEPPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDFMMMIKTPIFIYNSFHQG-YALGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVITRPM-EGKMTHGKAIAMIIFIYLYATPWVVACYTESWGRFPEGYLTSCTFD--YLTDNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHNVDSNVDKSKEAAEIRIAKAAITICFLFFASWTPYGVMSLIGAFGDKTLLTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQKRCPWLAISEKAPESRAAEQQQTTAA---- >B1AR_MOUSE LPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLVALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACRRRAAHGCLARAGPPPSPG >O6A1_HUMAN ------------MEWRNHSGRVSEFVLLGFPAPVPIQVILFALLLLAYVLVLTENTLIIMAIRNHSTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFVGSKQLISFEGCMTQLYFFLGLGCTECVLLAVMANDRYMAICYLLNPVIVSGRLCVQMAAGSWAGGFGISMVKVFLISGL---SNHFFCDVSNLSCTDMSTAELTDFILAIFILLGPLSVTGASYVAITGAV--------MHIPSAAGRYKAFSTCASHFNVVIIFYAASIFIYARPKALS---AFDTNKLVSVLYAVIVPLLNPIIYCLRNQEVKRALCCILHLYQHQDPDPKKGSR------------ >GPR8_HUMAN PLDSRGSFSLPTMGANVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLAVADGLFTLVLPVNIAEHLLQY-WPFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLATVHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVYS-LQ-VPSCGLS-FPWPERVWFKASRVYTLVLGFVLPVCTICVLYTDLLRRLRAVR--RSGAKALGKARRKVTVLVLVVLAVCLLCWTPFHLASVVALTTDLPPLVISMSYVITSLTYANSCLNPFLYAFLDDNFRKNFRSILRC------------------------- >CCKR_.ENLA SSTNGTHNLTTANWPPWNLNCTPILDRKKPSPSDLNLWVRIVMYSVIFLLSVFGNTLIIIVLVMNKRLRTITNSFLLSLALSDLMVAVLCMPFTLIPNLMENFIFGEVICRAAAYFMGLSVSVSTFNLVAISIERYSAICNPLSRVWQTRSHAYRVIAATWVLSSIIMIPYLVYK----DRRVGHQCRLV---WPSKQVQQAWYVLLLTILFFIPGVVMIVAYGLISRELYRGKMDINNSEAKLMAKKRVIRMLIVIVAMFFICWMPIFVANTWKAFDELSTLTGAPISFIHLLSYTSACVNPLIYCFMNKRFRKAFLGTFSSCIKP----CRNFRATGASLSKFSYT >ETBR_RAT SSAPAEVTKGGRVAGVPPRS-FPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITRV--LRVCMLNQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFE-EKQSLEFKANDHGYDNFR >EDG2_HUMAN QPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIENCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTESSNHTILAGVHSND >5H1D_RAT SLPNQSLEGLPQEASNRSLNAT---GAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAAAMIAAVWAISICISIPPLFWR----H-E--SDCLVN-------TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRKLALERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS--------------------- >ET1R_BOVIN ELSFVVTTHQPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPRT--HRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPWKNHEQNNHNTE >GRE2_BALAM ----MSGGEASITGRTAPELN-ASAAPLDDERELGETVAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPIYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW-T-E--TPCTLT--------QR-LFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRSVHEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCPPSQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAFSRLLRCDRRMSA------------------- >LSHR_MOUSE ENELSGWDYDYDFCSPKTLQCTPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCSAAGFFTVFASELSVYTLTVITLERWHTITYAVLDQKLRLRHAIPIMLGGWIFSTLMATLPLVGVSSY----KVSICLPM-----VESTLSQVYILSILLLNAVAFVVICACYVRIYFAVQNP------ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPVNSCANPFLYAVFTKAFQRDFFLLLSRFGCCKHRAELYRRFNSKNGFPRSSK >MSHR_MOUSE STQEPQKSLLGSLNSN--ATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEVVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYY----------------------KKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHIAQKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW----------------------- >5H5A_RAT LPINLTSFSLSTPSTLEPNRSDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGE-S-E-SEECQVS--------REPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRATVTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW-DIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ----------------------- >BRS3_HUMAN QTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTMT--FESCTSY---VSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSIPTQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTMGTVPGTGSIQM >OPSD_CATBO GGGF-GNQTVVDKVPPEMLHLVDAHWYQFPPMNPLWHAILGFVIGILGMISVIGNGMVIYIFTTTKSLRTPSNLLVINLAISDFLMMLSMSPAMVINCYYETWVLGPLVCELYGLTGSLFGCGSIWTMTMIAFDRYNVIVKGLSAKPMTINGALLRILGIWFFSLGWTIAPMFGWNRYVPEGNMTACGTD--YLTKDLLSRSYILVYSFFCYFLPLFLIIYSYFFIIQAVAAHMNVRSAENQSTSAECKLAKVALMTISLWFMAWTPYLVINYAGIFETVK-INPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFQRFPSLACSSGPAG-ADTTEGTEKPAA--- >GASR_PRANA GSSLCHPGVSLLNSSSAGNLSCEPPRIRGTGTRELELAIRITLYAVIFLMSIGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLVAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQP---V-LQCMHR---WPSARVRQTWSVLLLMLLFFIPGVVMAVAYGLISRELYLGTPGASANQAKLLAKKRVVRMLLVIVLLFFLCWLPIYSANTWCAFDGPGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPSIASLSRLSYT >P2Y3_CHICK ----------------MSMANFTGGRNSCTFHEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLAMADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTG-----RTVCYDL-SPPDRSTSYFPYGITLTITGFLLPFAAILACYCSMARILCQK---ELIGLAVHKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRQDHCISY------------ >AG2R_.ENLA -----MSNASTVETSDVERIAVNC---SKSGMHNYIFIAIPIIYSTIFVVGVFGNSMVVIVIYSYMKMKTVASIFLMNLALSDLCFVITLPLWAAYTAMHYHWPFGNFLCKVASTAITLNLYTTVFLLTCLSIDRYSAIVHPMSRIWRTAMVARLTCVGIWLVAFLASMPSIIYRQIYL-TN--TVCAIV-YDSGHIYFMVGMSLAKNIVGFLIPFLIILTSYTLIGKTLKEV------YRAQRARNDDIFKMIVAVVLLFFFCWIPYQVFTFLDVLIQMDDIVDTGMPITICIAYFNSCLNPFLYGFFGKNFRKHFLQLIKYIPPKMRTHASVNTSLSD-------T >FSHR_PIG FDTMYSEFDYDLCNEVVDVICSPEPDTFNPCEDIMGHDILRVLIWFISILAITGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKTWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLQCKVQLRHAASIMLVGWIFAFTVALFPIFGISSY----KVSICLPM-----IDSPLSQLYVVSLLVLNVLAFVVICGCYTHIYLTVRNP------NIMSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDVFILLSKFGCYEMQAQTYRTNIHPRNGHCPPA >MSHR_DAMDA PVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >ETBR_HORSE LSAPPQMPKAGRTAGAQRRTLPPPPCERTIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDMITRI--LRICLLHQKTAFMQFYKNAKDWWLFSFYFCLPLAITAFFYTLETCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKHTLYDQSFLLVLEYIGINMASLNSCINPIALYLVSKRFKNCFKWCLCCWCQSFE-EKQSLEFKANDHGYDNFR >MSHR_CAPHI PALGSPRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSVLSITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >AG2S_RAT ------MTLNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKA----YKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTRPSD-------N >D5DR_FUGRU NFYNETEPTEPRGGVDPLRVVTAAEDVPAPVGGVSVRALTGCVLCALIVSTLLGNTLVCAAVIKFRHRSKVTNAFVVSLAVSDLFVAVLVMPWRAVSEVAGVWLFG-RFCDTWVAFDIMCSTASILNLCVISMDRYWAISNPFYERRMTRRFAFLMIAVAWTLSVLISFIPVQLNWHRASS-EQGDCNAS--------LNRTYAISSSLISFYIPVLIMVGTYTRIFRIAQTQRASESALKTSFKRETKVLKTLSVIMGVFVFCWLPFFVLNCVVPFCDVDCVSDTTFNIFVWFGWANSSLNPVIYAFNA-DFRKAFTTILGCSKFCSSSAVQAVDYHHDTTLQK--- >PI2R_BOVIN ------------------------MADSCRNLTYVRDSVGPATSTLMFVAGVVGNGLALGILGARRHRPSAFAVLVTGLGVTDLLGTCFLSPAVFAAYARNSARGRPALCDAFAFAMTFFGLASTLILFAMAVERCLALSHPYYAQLDGPRRARLALPAIYAFCTIFCSLPFLGLGQHQQYCPGSWCFIR---MRSAEPGGCAFLLAYASLVALLVAAIVLCNGSVTLSLCRMQRRRCPRPRAGEDEVDHLILLALMTGIMAVCSLPLTPQIRGFTQAIAPDSSEMGDLLAFRFNAFNPILDPWVFILFRKSVFQRLKLWFCCLYSRPAQGDSRTSRKDSSAPPALEG >A1AA_RABIT ----------MVFLSGNASDSSNCT-HPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKREAKNFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALSQ---------- >OPS4_DROPS SSGSDELQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLKAPIFIYNSFHRG-FALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPM-NRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFPEGYLTSCSFD--YLSDNFDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHNVESNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQKRCPWLGVNEKSGEASSAQTQQTSAA---- >5H1F_RAT -------------MDFLNSSD-QNLTSEELLNRMPSKILVSLTLSGLALMTTTINCLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQGLCDLWLSVDIICCTCSILHLSAIALDRYRAITDAVYARKRTPRHAGITITTVWVISVFISVPPLFWR----S-R--DQCIIK-------HDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLLKHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRN----------------------- >NK2R_CAVPO ----MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPF-QPRLSAPSTKAVIGGIWLVALALAFPQCFYST---GA---TKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRRHQHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEE----HTPSFSLRVNRC >5H1A_RAT -MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRT---DP--DACTIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRKNEEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR-------------------- >ACM2_PIG --------------MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VE-DGECYIQ------FFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >GPRV_HUMAN -----------------------MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALRFLLDLSRSVGMAFLAAVALDRYLRVVHPRKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQ--S--TRCHSF-YSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKR----LREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLCAVAHTSDVTGSLTYLHSVVNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDF------------ >YT66_CAEEL ----------------------------------------MGVTFHPGIVGNITNLMVLASRR-------LRAMYLRALAVADLLCMLFVLVFVSTEYLAKNKLYQIYQCHLMLTLINWALGAGVYVVVALSLERYISIVFPMFRTWNSPQRATRAIVIAFLIPAIFYVPYAITRYKGK---VTIYSMDD---IYTTFYWQIYKWTREAILRFLPIIILTVLNIQIMIAFRKRMFQNKRKEQGTQKDDTLMYMLGGTVLMSLVCNIPAAINLLLIDETLKKLDYQIFRAVANILEITNHASQFYVFCACSTDYRTTFLQKFPCFKTDYANRDRLRSVIQKQGSVEHTT >RGR_MOUSE ---------------------MAATRALPAGLGELEVLAVGTVLLMEALSGISLNGLTIFSFCKTPDLRTPSNLLVLSLALADTGISLNALVAAVSSLLRR-WPHGSEGCQVHGFQGFATALASICGSAAVAWGRYHHYCTRR---QLAWDTAIPLVLFVWMSSAFWASLPLMGWGHYDYEPVGTCCTLD--YSRGDRNFISFLFTMAFFNFLVPLFITHTSYRFME--------------QKFSRSGHLPVNTTLPGRMLLLGWGPYALLYLYAAIADVSFISPKLQMVPALIAKTMPTINAINYALHREMVCRGTWQCLSPQKSKKDRTQA--------------- >A2AA_PIG ----MGSLQPEAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKAQ-P--PRCEIN--------DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRRGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >PI2R_HUMAN ------------------------MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPRPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLR---MRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMKRHLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDS-SSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPRRDPRAPSAPVG >AA3R_CANFA -------------------------MAVNGTALLLANVTYITVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLG--ITIQFYNCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWN-MKE-H-FLSCQFS-----SVMRMDYMVYFSFFTWILIPLVVMCAIYLDIFYVIRNK--NSKETGAFYGREFKTAKSLFLVLFLFAFSWLPLSIINCITYFHGE--VPQIILYLGILLSHANSMMNPIVYAYKIKKFKETYLLIFKTYMICQSSDSLDSS------------ >CB1R_MOUSE EFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCK-K--LQSVCSDI------FPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGHANNTASMHRAA >OPSD_CANFA MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFAIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSDFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMITTLCCGKNPLGDDEASASASKTETSQVAPA >BRS3_CAVPO QTLISITNDTESSSSVVSNDTTNKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLALGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPSNAILKTCAKAGCIWIMSMIFALPEAIFSNVHTMT--SEWCAFY---VSEKLLQEIHALLSFLVFYIIPLSIISVYYSLIARTLYKSIPTQSHARKQVESRKRIAKTVLVLVALFALCWLPNHLLNLYHSFTHKAAIHFIVTIFSRVLAFSNSCVNPFALYWLSKTFQKQFKAQLFCCKGELPEPPLAATMGRVSGTENTHI >OPSD_DIPAN MNGTEGPFFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWTMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFTIPLTVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVIMMVIAFLVCWLPYASVAWYIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >AG2R_MOUSE ------MALNSSTEDGIKRIQDDC---PRAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYF-TN--TVCAFH-YESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------N >YMJC_CAEEL NLRLNESPYKYVMSNNTTIPSCLTDRQMSLSVSSTEGVLIGTIIPILVLFGISGNILNLTVLLAPNL-RTRSNQLLACLAVADIVSLVVILPHSMAHYETFERKFYGKYKFQIIAMTNWSIATATWLVFVICLERLIIIKYPLPRNVVTIIVVTTFILTSYNHVSHACAEKLFCNGTQY--S-RWFRNEPPNSEFMKSVVRVAPQVNAIFVVLIPVVLVIIFNVMLILTLRQRKTISQFTQLQSKTEHKVTITVTAIVTCFTITQSPSAFVTFLSSYVH--RDWVTLSAICTILVVLGKALNFVLFCLSSASFRQRLLMQTKQGILRKSTRYTSVA------------ >OPSG_ASTFA NE--ETTRESAFVYTNANNTRDPFEGPNYHIAPRWVYNLASLWMIIVVIASIFTNSLVIVATAKFKKLRHPLNWILVNLAIADLGETVLASTISVFNQVFGYFVLGHPMCIFEGWTVSVCGITALWSLTIISWERWVVVCKPFGNVKFDGKWAAGGIIFAWTWAIIWCTPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVASYMVTLLLTCCILPLSVIIICYIFVWNAIHQVAQQQKDSESTQKAEKEVSRMVVVMILAFILCWGPYASFATFSALNPGYAWHPLAAALPAYFAKSATIYNPIIYVFMNRQFRSCIMQLFGKKVEDA-----SEVSTAS-------- >DUFF_HUMAN FEDVWNSSYGVNDSFPDGDYDANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGST--RSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQ--------VPGLTLGLTVGIWGVAALLTLPVTLASG------SGGLCTLI-YSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKA-------------------LGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGS------------ >OPR._RAT GSHFQGNLSLLN---ETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEE---IECLVE-IPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVGLGCKTSETVPR >TRFR_SHEEP ------------MENETGSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLSLNSNRYFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPVEKPANYSVKESDHFSTELDD >ACTR_MESAU -------------MKHIITPYEHTNDTARNNSDCPDVVLPEEIFFTISIIGVLENLIVLLAVVKNKNLQCPMYFFICSLAISDMLGSLYKILENILIMFRNRGNFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALYHSIVTMRRTIITLTVIWIFCTGSGIAMVIFFS----------------------HHHVPTVLTFTSLFPLMLVFILCLYIHMFLLARSH---ARKISTLPRANMKGAITLTILLGVFIFCWAPFILHVLLMTFCPNNVCYMSLFQINGMLIMCNAVIDPFIYAFRSPELRDAFKKMFSCHRYQ--------------------- >CKR7_HUMAN QDEVTDDYIGDNTTVDYTLFESLC---SKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKS--WVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQR-SE-AMRCSLI---TEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTL---------LQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWS--------HIRR >O.YR_SHEEP GAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLSLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLAVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFKQMWSVWDADA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFQDLVQRFLCCSFRRLKGSQLGEHSYTFVLSRHSS >GPR7_HUMAN MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATARVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD--QG-RRQCVLV-FPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMR--DSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPPLVIAISYFITSLTYANSCLNPFLYAFLDASFRRNLRQLITCRAAA--------------------- >GPRJ_HUMAN TETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPL-SFKVSREKAKKMIAASWIFDAGFVTPVLFFYG---SNW-HCNYFLP-----SSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIDGR-RTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTIKKNYVGISEIPS >OAJ1_HUMAN --MLLCFRFGNQSMKRENFTLITDFVFQGFSSFHEQQITLFGVFLALYILTLAGNIIIVTIIRIDLHLHTPMYFFLSMLSTSETVYTLVILPRMLSSLVGMSQPMSLAGCATQMFFFVTFGITNCFLLTAMGYDRYVAICNPLYMVIMNKRLRIQLVLGACSIGLIVAITQVTSVFRL---PPHFFCDIRKLSCIDTTVNEILTLIISVLVLVVPMGLVFISYVLIISTI--------LKIASVEGRKKAFATCASHLTVVIVHYSCASIAYLKPKSEN---TREHDQLISVTYTVITPLLNPVVYTLRNKEVKDALCRAVGGKFS---------------------- >RDC1_CANFA YAEPGNFSDISWPCNSSDCIVVDTVLCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVVTIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLTCMSVDRYLSITYFATSSRRKKVVRRAVCVLVWLLAFCVSLPDTYYLKTVTNNE--TYCRSFYPEHSVKEWLISMELVSVVLGFAIPFCVIAVFYCLLARAI---------SASSDQEKQSSRKIIFSYVVVFLVCWLPYHVVVLLDIFSILHNFLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNAK-- >CML1_RAT EYEGYNDSSIYGEEYSDGSDYIVDLEEAGPLEAKVAEVFLVVIYSLVCFLGILGNGLVIVIATFKMK-KTVNTVWFVNLAVADFLFNIFLPIHITYAAMDYHWVFGKAMCKISSFLLSHNMYTSVFLLTVISFDRCISVLLPVSQNHRSVRLAYMTCVVVWVWLSSESPPSLVFGHVST-SF--HSTHPR-TDPVGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKL---------QRNRQAKTKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVSVFSLGLPLATAVAIANSCMNPILYVFMGHDFKK-FKVALFSRLVNALSEDTGPSFTKMSSLIEKAS >FSHR_EQUAS --MMYSEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYDILRVLIWFISILAITGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFGSELSVYTLTAITLERWHTITHAMLECKVQLRHAASVMLVGWIFGFGVGLLPIFGISTY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NIVSSSSDTKIAKRMGILIFTDFLCMAPISFFGISASLKVALITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQTYRTISHPKNGPCPPT >OPSD_MULSU MNGTEGPYFYIPMVNTTGIVRSPYDYPQYYLVNPAAYAALGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAVERWMVVCKPISNFRFGENHAIMGLAMTWLMASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFCCHFMIPLIIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLVCWLPYASVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICMNKQFRNCMITTLCCGKNPFEEEEGASSSSVSSSSVSPAA >NK3R_HUMAN GNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATKIVIGSIWILAFLLAFPQCLYSK---GR---TLCFVQ--WPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGG--PCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSY----TTRFHPNRQSSM >CKR5_CERTO ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSPHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >PI2R_MOUSE DGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIR---MRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMRRHFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDS--REMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPRRDPPAPTSLQA >FSHR_CHICK FGPVENEFDYGLCNEVVDFVCSPKPDAFNPCEDIMGYNVLRVLIWFINILAITGNTTVLIILISSQYKLTVPRFLMCNLAFADLCIGIYLLFIASVDIQTKSWQTG-AGCNAAGFFTVFASELSVYTLTVITLERWHTITYAMLNRKVRLRHAVIIMVFGWMFAFTVALLPIFGISSY----KVSICLPM-----IETPFSQAYVIFLLVLNVLAFVIICICYICIYFTVRNP------NVISSNSDTKIAKRMAILIFTDFLCMAPISFFAISASLRVPLITVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDFFILLSKFGCCEMQAQIYRTNFHTRNGHYPTA >OPRM_BOVIN FSHLEGNLSDPCGPNRTELGGSDRLCPSAGSPSMITAIIIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDLRTPRNAKIINICNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPILIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRIPSTANTVDRTNH >P2Y5_HUMAN --------------------MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLVSNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRN-WPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHS---ASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKP----VTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGNLQTLKSKIFDN >HM74_HUMAN ----------MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWNFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQ-PA--NVCISF-----SICHTFRWHEAMFLLEFLLPLGIILFCSARIIWSLRQR------QMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNTGDPNKTRGAPE >OPSD_DICLA MNGTEGPFFYVPMVNTTGIVRSPYDYPQYYLVSPAAYAALGAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNMEGFFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFGENHAIMGLAFTWVMACSCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFACHFIIPMCVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVVIMGIAFLICWCPYASVAWYIFTHQGSEFGPVFMTLPAFFAKTSSVYNPLIYILMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >GPRW_HUMAN GTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMA-RTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQ-WLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTR-FNSNETAQIWI-----VVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKL---------LREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRV-PRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSPRE--------- >UL33_HSV6U --------------------MDTVIELSKLQFKGNASCTSTPTLKTARIMESAVTGITLTTSIPMIIKHNATSFYVITLFASDFVLMWCVFFMTVNRKQL--FSFNRFFCQLVYFIYHAVCSYSISMLAIIATIRYK-TLHRRKKTESKTSSTGRNIGILLLASSMCAIPTALFVKTNGM-KKTGKCVVYSSKKAY-ELFLAVKIVFSFIWGVLPTMVFSFFYVIFCKAL---------HDVTEKKYKKTLFFIRILLLSFLLIQIPYIAILICEIAFLYMARVEILQLIIRLMPQVHCFSNPLVYAFTGGELRNRFTACFQSFFPKTLCSTQKRKDQNSKSKASVEK >A1AB_HUMAN HNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRRRRRRRRRTYRPWTRGGSLE >OPSD_SPHSP GG-Y-GNQTVVDKVLPEMLHLIDPHWYQFPPMNPLWHGLLGFVIGCLGFVSVVGNGMVIYIFSTTKGLRTPSNLLVVNLAFSDFLMMLSMSPPMVINCYYETWVLGPFMCELYALLGSLFGCGSIWTMVMIALDRYNVIVKGLAAKPMTNKTAMLRILGIWAMSIAWTVFPLFGWNRYVPEGNMTACGTD--YLNKEWVSRSYILVYSVFVYFLPLATIIYSYWFIVQAVSAHMNVRSAENANTSAECKLAKVALMTISLWFFAWTPYLVTDFSGIFEWGK-ISPLATIWCSLFAKANAVYNPIVYGISHPKYRAALNKKFPSLACASEPDDTASQSDEKSASA---- >ET1R_RAT EFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPRT--HRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPWKNQEQN-HNTE >B1AR_PIG LPDGAATAARLLVPASPPASLLTPASEGSVQLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRAAR-ALVCTVWAISALVSFLPILMHWWRDR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRVARGSCAAAGCLAVARPPPSPG >OLF3_RAT -------------MDSSNRTRVSEFLLLGFVENKDLQPLIYGLFLSMYLVTVIGNISIIVAIISDPCLHTPMYFFLSNLSFVDICFISTTVPKMLVNIQTQNNVITYAGCITQIYFFLLFVELDNFLLTIMAYDRYVAICHPMYTVIMNYKLCGFLVLVSWIVSVLHALFQSLMMLAL---PPHYFCEPNQLTCSDAFLNDLVIYFTLVLLATVPLAGIFYSYFKIVSSI--------CAISSVHGKYKAFSTCASHLSVVSLFYCTGLGVYLSSAANN---SSQASATASVMYTVVTPMVNPFIYSLRNKDVKSVLKKTLCEEVIRSPPSLLHFFCFIFCY------ >5H5A_HUMAN LPVNLTSFSLSTPSPLETNHSGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGE-S-E-SEECQVS--------REPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRATVPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSC-DIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH----------------------- >OPRD_RAT FSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPGA---VVCTLQ-FPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL-SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRVTACTPSDGPG >CKRV_MOUSE EIPAVTEPSYNTVAKNDFMSGFLC---FSINVRAFGITVPTPLYSLVFIIGVIGHVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLSTLPFWVDYIMKGD-WIFGNAMCKFVSGFYYLGLYSDMFFITLLTIDRYLAVVHVVALRARTVTFGIISSIITWVLAALVSIPCLYVFKSQM-EF-YHTCRAILPRKSLIRFLRFQALTMNILGLILPLLAMIICYTRIINVL---------HRRPNKKKAKVMRLIFVITLLFFLLLAPYYLAAFVSAFEDVLQQVDLSLMITEALAYTHCCVNPVIYVFVGKRFRKYLWQLFRRHTAITLPQWLPFLA-------SARL >THRR_RAT PLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAACYCNMYASIMLMTVISIDRFLAVVYPISLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQ--N--TTCHDVLNETLLHGFYSYYFSAFSAIFFLVPLIISTVCYTSIIRCL------SSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDETAYFAYLLCVCVTSVASCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGDTCS-------- >DADR_PIG --------------MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-TTHNCDSS--------LSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQAECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGCIDSITFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPTSTNAIETAVVFSSH----- >GRHR_BOVIN --MANSDSPEQNENHCSAINSSIPLTPGSLPTLTLSGKIRVTVTFFLFLLSTIFNTSFLLKLQNWTQKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITKPL-AVKSNSKLGQFMIGLAWLLSSIFAGPQLYIFGMIHEG--FSQCVTH--SFPQWWHQAFYNFFTFSCLFIIPLLIMVICNAKIIFTLTRVPHKNQSKNNIPRARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPDMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >OLF3_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIRLISVDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERKTISYVGCILQYFSFVLLTTSECLLLAVMAYDRYVAICKPLYPAIMTKAVCWRLVESLYFLAFLNSLVHTCGLLKL---SNHFFCDISQISSSSIAISELLVIISGSLFVMSSIIIILISYVFIILTV--------VMIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRLTATTFGFIDSKAVQ-------------- >ML1A_PHOSU -------MKGNGSTLLNASQQAPGVGEGGGPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAIADLVVAIYPYPLVLTSIFNNGWNLGYLHCQISAFLMGLSVIGSIFNITGIAINRYCYICHSLYDRLYSNKNSLCYVFLIWVLTLVAIMPNLQTGT-LQYDP-IYSCTFT------QSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWILVLQVRR-PDSKPRLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLIVASDPATRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRQEYKRILVSLFTAKMCFVDSSNCKPAPLIANNNL >NY2R_HUMAN EEMKVEQYGP-QTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKRISFLIIGLAWGISALLASPLAIFREYSLFE--IVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHSPG-AANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKNLEVRKNSG >FMLR_HUMAN -----------METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMT-HTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFLFTIVDINLFGSVFLIALIALDRCVCVLHPVTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPSPWPKERINVA------VAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKI---------HKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIREKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTTL---------- >NK1R_CAVPO -----MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVICVIWVLALLLAFPQGYYST---GR---VVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLE---IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADY----STRYFQTQGSVY >ML1B_HUMAN NGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS-LEYDP-IYSCTFI------QTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARK-PESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKQSPAPPIIGVQH >C3AR_RAT --------------MESFTADTNSTDLHSRPLFKPQDIASMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPICQNHRSVRTAFAVCGCVWVVTFVMCIPVFVYRDLLV-ED-DYFDQLM-YGNHAWTPQVAITISRLVVGFLVPFFIMITCYSLIVFRM--------RKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQEEVVLPWDHMSIALASANSCFNPFLYALLGKDFRKKARQSVKGILEAAFSEELTHSAPS--------- >OPSB_GECGE MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLADPWKFKVLSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIGGQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWSRFIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVREAAAQQQESATTQKAEKEVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQFRNCMVTTICCGKNPFGDEDVSSSVSSVSSSQVAPA >SSR5_RAT LSLASTPSWNAS---AASSGNHNWSLVGSASPMGARAVLVPVLYLLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLSARWRRPRVAKMASAAVWVFSLLMSLPLLVFADVQE-----GTCNLS-WPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAMR--VGSSRRRRSEPKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIERPQATLPTRSCE >B2AR_CANFA MGQPANRSVFLLAPNGSHAPDQ----GDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQGRSHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWVGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGYSDYAGEHSGCHLG >CKR6_MOUSE FGTDDYDN---TEYYSIPPDHGPC---SLEEVRNFTKVFVPIAYSLICVFGLLGNIMVVMTFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATNT-WVFSDALCKLMKGTYAVNFNCGMLLLACISMDRYIAIVQATRVRSRTLTHSKVICVAVWFISIIISSPTFIFNKKYE-LQ-RDVCEPRRSVSEPITWKLLGMGLELFFGFFTPLLFMVFCYLFIIKTL---------VQAQNSKRHRAIRVVIAVVLVFLACQIPHNMVLLVTAVNTGKKVLAYTRNVAEVLAFLHCCLNPVLYAFIGQKFRNYFMKIMKDVWCMRRKNKMPGFESY-----ISRQ >NYR_DROME TLSGLQFETYNITVMMNFSCDDYDLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCEPSSFISLFILNWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPL-KPRITKRYATFIIAGVWFIALATALPIPIVSGLDI---WHTKCEKYREMWPSRSQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKPGETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFADPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVSGTGPALPLNRM >HH2R_MOUSE -------------------MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWRFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWN--RN-TF-KCKVQ--------VNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQR--ISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDD-VNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRRSQSREGRW--- >TRFR_BOVIN -----------MENETGSELN-QTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNLNSNRYFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPVEKPANYSVKESDRFSTELDD >OPSP_ICTPU -------MASIILINFSETDTLHLGSVNDHIMPRIGYTILSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFFGIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWGSYQLEGVMTSCAPN--WYRRDPVNVSYILCYFMLCFALPFATIIFSYMHLLHTLWQVAKLVADSGSTAKVEVQVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQFRDYALPCLLCGKNPWAAKEGRDSTVSKNTSVSPL- >OPSR_.ENLA NDDDDTTRSSVFTYTNSNNTRGPFEGPNYHIAPRWVYNLTSIWMIFVVFASVFTNGLVIVATLKFKKLRHPLNWILVNMAIADLGETVIASTISVFNQIFGYFILGHPMCVLEGFTVSTCGITALWSLTVIAWERWFVVCKPFGNIKFDEKLAATGIIFSWVWSAGWCAPPMFGWSRFWPHGLKTSCGPDVFSGSSDPGVQSYMLVLMITCCIIPLAIIILCYLHVWWTIRQVAQQQKESESTQKAEREVSRMVVVMIVAYIFCWGPYTFFACFAAFSPGYSFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIYQMFGKKVDDG-----SEVVSSVSNSSVSPA >ML1._MOUSE ---------MGPTKAVPTPFGCIGCKLPKPDYPPALIIFMFCAMVITVVVDLIGNSMVILAVTKNKKLRNSGNIFVASLSVADMLVAIYPYPLMLYAMSVGGWDLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYICHSLYKRIFSLRNTCIYLVVTWVMTVLAVLPNMYIGT-IEYDP-TYTCIFN------YVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWIKVLAARD-AGQNPDNQFAEVRNFLTMFVIFLLFAVCWCPVNVLTVLVAVIPKEKIPNWLYLAAYCIAYFNSCLNAIIYGILNESFRREYWTIFHAMRHPILFISHLISTRALTRARVRAR >OPSG_CHICK MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWSRYMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVREAAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTICCGKNPFGDEDVSSTVSSVSSSQVSPA >GRHR_HUMAN --MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPL-ALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHKV--FSQCVTH--SFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVPHENQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >5HT2_APLCA ----------------MLCGRLRHTMNSTTCFFSHRTVLIGIVGSLIIAVSVVGNVLVCLAIFTEPISHSKSKFFIVSLAVADLLLALLVMTFALVNSLYGYWLFGETFCFIWMSADVMCETASIFSICVISYNRLKQVQKPLYEEFMTTTRALLIIASLWICSFVVSFVPFFLEWHELGD-PKPECLFD--------VHFIYSVIYSLFCFYIPCTLMLRNYLRLFLIAKKH-RIHRLHRNQGTQGSKAARTLTIITGTFLACWLPFFIINPIEAVDEHL-IPLECFMVTIWLGYFNSCVNPIIYGTSNSKFRAAFQRLLRCRSVKSTVSSISPVSWIRPSLLDGP- >OPSD_ASTFA MNGTEGPYFYVPMSNATGVVRSPYEYPQYYLAPPWAYACLAAYMFFLILVGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSLNGYFVFGRLGCNLEGFFATFGGINSLWCLVVLSIERWVVVCKPMSNFRFGENHAIMGVAFTWFMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVVHFLTPLFVITFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVILMFIAYLVCWLPYASVSWWIFTNQGSEFGPIFMTVPAFFAKSSSIYNPVIYICLNKQFRHCMITTLCCGKNPF--EEEEGATEASSVSSVSPA >5H2C_HUMAN GLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD-VF--NTTCVL---------NDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQKKKPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIALSGRELNVNIY >DBDR_RAT PGRNRTAQPARLGLQRQLAQVDAPAG--SATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-TFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDEG-RTENCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQRGADPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGCVSETTFDIFVWFGWANSSLNPIIYAFNA-DFRKVFAQLLGCSHFCFRTPVQTVNYNQDTVFHK--- >EDG1_MOUSE VKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPSMGWNCI-S--SLSSCSTV------LPLYHKHYILFCTTVFTLLLLSIAILYCRIYSLVRTRLTFISKGSRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKEFSRSKSDNSSH >B3AR_BOVIN MAPWPPGNSSLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRALAAVVLVWVVSAAVSFAPIMSKWWRIQ-R--RCCTFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPS-VSGPTFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCR---PEEHLAAAGAPTALTSPAGP >NY2R_CAVPO EEIKVEPYGPGHTTPRGELAPDPEPELIDSTKLTEVRVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTVTLTVIALDRHRCIVYHL-DSKISKQNSFLIIGLAWGISALLASPLAIFREYSLFE--IVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISVSYVRIWSKLKNHSPG-AANDHYHQRRQKTTKMLVFVVVVFAVSWLPLHAFQLAVDIDSQVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCQQRLDAIQSE---AKTNVEVEKNHG >PE22_RAT ---------------MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQLAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQ--------HGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMRGPRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSS---RKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGAS--QTDLCGQL-- >A2AB_MOUSE --------------------MSGPAMVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCELN--------QEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSGVAWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTGW------------------ >AG2S_HUMAN ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF-TN--TVCAFH-YESRNSTLPIGLGLTKNILGSCFPFLIILTSYTLIWKALKKA----YEIQKNNPRNDDIFRIIMAIVLFFFFSWIPHQIFTFLDVLIQQGDIVDTAMPITIWIAYFNNCLNPLFYGFLGKKFKKDILQLLKYIPPKAKSHSNLSTRPSD-------N >B2AR_BOVIN MGQPGNRSVFLLAPNASHAPDQ----NVTLERDEAWVVGMGILMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGACHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYLAITSPFYQCLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQPYAIASSIVSFYLPLVVMVFVYSRVFQVAKRQGRSQRRTSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIKDNL-IRKEIYILLNWLGYINSAFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGCSDYTGEQSGYHLG >IL8B_RABIT G--DFSNYSYSTDLPPTLLDSAPC----RSESLETNSYVVLITYILVFLLSLLGNSLVMLVILYSRSTCSVTDVYLLNLAIADLLFATTLPIWAASKVHG--WTFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTMIQKRHLVKFICLSMWGVSLILSLPILLFRNAIF-NS-SPVCYED-MGNSTAKWRMVLRILPQTFGFILPLLVMLFCYVFTLRTL---------FQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLTDTLMRTHNDIDRALDATEILGFLHSCLNPIIYAFIGQKFRYGLLKILAAHGLISKEFLAKES------------ >GASR_RAT GSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQP---V-LQCMHR---WPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGPGPPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPSIASLSRLSYT >A1AB_MOUSE HNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGCLG-AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTDLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRTYRPWTRGGSLE >OPSR_FELCA AGLEDSTRASIFTYTNSNATRGPFEGPNYHIAPRWVYHVTSAWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIAGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMITCCIIPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVMVMIFAYCVCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCIMQLFGKKVDDG-----SELASSV--SSVSPA >P2Y7_HUMAN -------------------MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPK--NMSLCFPR---YPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRL---------QARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTQTARSGPAALEP >GPRL_HUMAN ---------MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITKPLYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWG---K-P-VFQWCAE-----SWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHRFSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFLTTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDGPLNGCHI---- >CKR3_MOUSE TDEIKTVVESFETTPYEYEWAPPC---EKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNE-WGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVALRARTVTFATITSIITWGLAGLAALPEFIFHESQD-SF-EFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLVMVICYSGIIKTL---------LRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHRTFKHLDLAMQVTEVIAYTHCCVNPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLT-------SSVS >HH1R_MOUSE ----------MRLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLGVLYAVRSERKLHTVGNLYIVSLSVADLIVGAIVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASATILGAWFLSFLWVIPILGWHHFT--EL-EDKCETD------FYNVTWFKIMTAIINFYLPTLLMLWFYVKIYNGVRRHLRSQYVSGLHLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSC-CSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS----------------------- >SSR1_HUMAN GEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAADG--TVACNML-MPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQ--DDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLS-----WMDNAAETALKSRAYSVED >MC5R_MOUSE -MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNDTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALYHHIMTARRSGVIIACIWTFCISCGIVFIIYYY----------------------EESKYVIICLISMFFTMLFFMVSLYIHMFLLARNH-RIPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY------------ >OPSD_CHELA MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFSEDHAIMGLAFTWVMASACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLVCWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >OLF6_RAT ----------MAWSTGQNLSTPGPFILLGFPGPRSMRIGLFLLFLVMYLLTVVGNLAIISLVGAHRCLQTPMYFFLCNLSFLEIWFTTACVPKTLATFAPRGGVISLAGCATQMYFVFSLGCTEYFLLAVMAYDRYLAICLPLYGGIMTPGLAMRLALGSWLCGFSAITVPATLIARL---SNHFFCDISVLSCTDTQVVELVSFGIAFCVILGSCGITLVSYAYIITTI--------IKIPSARGRHRAFSTCSSHLTVVLIWYGSTIFLHVRTSVES---SLDLTKAITVLNTIVTPVLNPFIYTLRNKDVKEALRRTVKGK------------------------ >D4DR_HUMAN ---MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLN---G-R--AVCRL---------EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWPPPRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC----------------------- >NY2R_MOUSE VEVKVEPYGPGHTTPRGELPPDPEPELIDSTKLVEVQVILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKRISFLIIGLAWGISALLASPLAIFREYSLFE--IVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLRNHSPG-AASDHYHQRRHKMTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKNLEVKKNNG >ETBR_MOUSE SSAPAEVTKGGRGAGVPPRS-FPPPCQRNIEISKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDMITRV--LRVCMLNQKTAFMQFYKTAKDWWLFSFYFCLPLAITAVFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFE-EKQSLEFKANDHGYDNFR >NK2R_RAT ----MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAIIAGIWLVALALASPQCFYST---GA---TKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRPRHHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----HTPSLSRRVNRC >OPR._MOUSE GSHFQGNLSLLN---ETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEE---IECLVE-IPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVGLGCKTSETVPR >YLD1_CAEEL --------------------------MIIFYLYVATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVGTSWTYNLYYDWWYG-DLCTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNPLQKRPLSRKRSVIAILIIWVVSTVTALPFAIAASVNSVTSKAHVCSAP--------VNTFFEKVLFGIQYALPIIILGSTFTRIAVAFRATEATSSLKNNHTRAKSKAVKMLFLMVVAFVVCWLPYHIYHAFALEEFFDARGKYAYLLIYWIAMSSCAYNPIIYCFANERFRIGFRYVFRWIPVIDCKKEQYEYMRSMAISLQKGR >5HT_BOMMO LPLQNCSWNSTGWEPNWNVTVWQASAPFDTPAALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLVACLVMPLGAVYEVVQRWTLGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTNI-YIHASTAKRVGMMIACVWTVSFFVCIAQLLGWKDPDS-E--LRCVVS--------QDVGYQIFATASSFYVPVLIILILYWRIYQTARKRPSLKPKEAADSKRERKAAKTLAIITGAFVACWLPFFVLAILVPTCDC-EVSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLLCGRRVRRRRAPQ--------------- >OPSD_SALPV MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILLGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWIMACACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFTCHFCIPLTIIGFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVILMVVGFLVCWLPYASVAWYIFSNQGSQFGPLFMTIPAFFAKSSSVYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSSVSSSSVSPAA >OPSD_LITMO MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLMVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLICWCPYAGVAWWIFTHQGSDFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >P2UR_RAT ----MAAGLDSWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLSLSWGHARYARRVAAVVWVLVLACQAPVLYFVTTS-----RITCHDT-SARELFSHFVAYSSVMLGLLFAVPFSIILVCYVLMARRLLKP---AYGTTGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPATEPTPSPQARRKLTDTVRKDLSISS >OLF4_CHICK -------------MASGNCTTPTTFILSGLTDNPGLQMPLFMVFLAIYTITLLTNLGLIALISVDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERKTISYIGCILQYFSFVLLTVTESLLLAVMAYDRYVAICKPLYPSIMTKAVCWRLVKGLYSLAFLNSLVHTSGLLKL---SNHFFCDNSQISSSSTTLNELLVFIFGSLFAMSSIITILISYVFIILTV--------VRIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRVIATNVWIH-------------------- >LSHR_RAT ENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNY----KVSICLPM-----VESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNP------ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRSNCKNGFPGASK >MSHR_BOVIN PALGSQRRLLGSLNCTPPATLPFTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHKVILLCLVGLFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >PE24_RAT --------------------MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFID---WTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMAAAVASFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSRRTSSAMSGHSR >5H1B_FUGRU ----MEGTNNTTGWTHFDSTSNRTSKSFDEEVKLSYQVVTSFLLGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNRWTLGQIPCDIFISLDMLCCTSSILHLCVIALDRYWAITEPIYMKKRTPRRAAVLISVTWLVGFSISIPPMLIMRSQPA-N--KQCKIT--------QDPWYTIYSTFGAFYIPLTLMLVLYGRIFKAARFRRHEETKRKIALARERKTVKTLGIIMGTFILCWLPFFIVALVMPFCQESFMPHWLKDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHFCRA-------------------- >GP39_HUMAN -------MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYETSNMSICTNL-----SRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSRPPKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLTDSARFVQRPLL >BRB2_HUMAN FSADMLNVTLQGPTLNGTFAQSKC---PQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKE-HN--TACVIS---YPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNN---EMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGRIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQLRTS-------I >RDC1_HUMAN YAEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFSGIFFLTCMSVDRYLSITYFTTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTNNE--TYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI---------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNAK-- >OPSB_ASTFA QEFQEDFYIPIPLDTNNITALSPFLVPQDHLGGSGIFMIMTVFMLFLFIGGTSINVLTIVCTVQYKKLRSHLNYILVNLAISNLLVSTVGSFTAFVSFLNRYFIFGPTACKIEGFVATLGGMVSLWSLSVVAFERWLVICKPVGNFSFKGTHAIIGCALTWFFALLASTPPLFGWSRYIPEGLQCSCGPDWYTTENKYNNESYVMFLFCFCFGFPFTVILFCYGQLLFTLKSAAKAQADSASTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVFNRGQSFDLRLGTIPSCFSKASTVYNPVIYVFMNKQFRSCMMKLIFCGKSPFGDDEEASSSSVGPEK----- >CB1B_FUGRU TNASDFPLSNGSGEATQCGEDIVDNMECFMILTPAQQLVIVILAITLGTFTVLENFVVLCVILHSHTRSRPSYHFIGSLAVADLIGSIIFVYSFLDFHVLHR-KDSPSIFLFKLAGVIASFTASVGSLFLTAIDRYVSIHRPMYKRIITKTKAVIAFSVMWAISIEFSLLPLLGWNCK-R--LHSVCSDI------FPLIDEKYLMFWIGMTTVLLLFIIYAYMFILWKSHHHSEGQTVRPEQARMDLRLAKTLVLILVALIICWGPLLAIMVYDLFGRVNDFIKTVFAFCSMLCLLNSTINPVIYAMRSKDLRRAFVNICHMCRGTTQSLDSSAEVRSTGGRAGKDR >5H2B_HUMAN ILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIANQYNSRATAFIKITVVWLISIGIAIPVPIKGIET-NP---ITCVLT------KERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKRRTGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRNPMAENSKFFK >OAR2_LYMST RNFSVSADVWLCGANFSQEWQLMQPVCSTKYDSITIFITVAVVLTLITLWTILGNFFVLMALYRYGTLRTMSNCLIGNLAISDLLLAVTVLPISTVHDLLGYWVFGEFTCTLWLCMDVLYCTASIWGLCTVAFDRYLATVYPVYHDQRSVRKAVGCIVFVWIFSIVISFAPFIGWQHM-S-F--YQCILF--------TSSSYVLYSSMGSFVIPAILMAFMYVRIFVVLHNQRNKLSMKRRFELREQRATKRMLLIMACFCVCWMPFLFMYILRSVCDTCHMNQHFVAAIIWLGYVNSSLNPVLYTLFNDDFKVAFKRLIGARSPSAYRSPGPRR------------ >GRPR_HUMAN DCFLLNLEVDHFMHCN-ISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPQT--FISCAPY---HSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSLPVNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIR--SHSMTSLKSTNPSVA >DBDR_HUMAN PGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDED-NAENCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQSAADTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHCVSETTFDVFVWFGWANSSLNPVIYAFNA-DFQKVFAQLLGCSHFCSRTPVETVNYNQDIVFHK--- >B2AR_MESAU MGPPGNDSDFLLTTNGSHVPDH----DVTEERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYIAITSPFYQSLLTKNKARMVILMVWIVSGLTSFLPIQMHWYRAI-D--TCCDFF--------TNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQGRSLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWLGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSSKAYGNGYSDYMGEASGCQLG >5H1B_HUMAN PAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVYSAKRTPKRAAVMIALVWVFSISISLPPFFWR----E-E--SECVVN-------TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS--------------------- >GPRH_HUMAN ------MNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQVCL-QLYRE----------KASHHALVSLAVAFTFPFITTVTCYLLIIRSLR------QGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKAKSEL------- >ACM1_MOUSE ------------MNTSVPPAVSPNITVLAPGKGPWQVAFIGSTTGLLSLATVTGNLLVLISIKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTVNPMCYASCNKAFRDHFRLLLLCRWDKRRWRKIPKRPSRQC------- >B3AR_SHEEP MAPWPPGNSFLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--RCCTFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVDTRQGVPRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPS-VSGPTFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCPPEEHLAAASPPTVLTSPAGPRQP >A1AD_MOUSE TGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEP--VP--RFCGIT--------EEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTHTLLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR--LWPSLDRR-PALRLC >C5AR_CANFA SMNFSPPEYPDYG-TATLDPNIFVDESLNTPKLSVPDMIALVIFVMVFLVGVPGNFLVVWVTGFEVR-RTINAIWFLNLAVADLLSCLALPILFSSIVQQGYWPFGNAACRILPSLILLNMYASILLLTTISADRFVLVFNPICQNYRGPQLAWAACSVAWAVALLLTVPSFIFRGVHT-PF--MTCGVD-YSGVGVLVERGVAILRLLMGFLGPLVILSICYTFLLIRT---------WSRKATRSTKTLKVVVAVVVSFFVLWLPYQVTGMMMALFYKHRRVSRLDSLCVAVAYINCCINPIIYVLAAQGFHSRFLKSLPARLRQVLAEESVGRSTVD-------- >CKRA_HUMAN QVSWGHYSGDEEDAYSAEPLPELC---YKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRARSPTSAHLLQLALADLLLALTLPFAAAGALQG--WSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALGPRPSTPGRAHLVSVIVWLLSLLLALPALLFS--QD-RE-QRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTL---------LAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSSPSGPQPRRGC--------PRLS >MTR_BUFMA LNLDCSELPNSSWVNSSMENQSSNSTRDPLKRNEEVAKVEVTVLALILFLALAGNICVLLGIYINRHKHSRMYFFMKHLSIADLVVAIFQVLPQLIWDITFRFYAPDLVCRLVTYLQVVGMFASTYMLLLMSLDRCLAICQPL--RSLHRRSDCVYVLFTWILSFLLSTPQTVIFSLTE----VYDCRAD---FIQPWGPKAYITWITLAVYIIPVMILSVCYGLISYKIWQNRATVSSVRLISKAKIRTVKMTFIIVLAYIVCWTPFFFVQMWSVWDPNP-KEASLFIIAMLLGSLNSCCNPWIYMLFTGHLFHDLLQSFLCCSARYLKTQQQGSSNSSTFVLSRKS >B1AR_HUMAN LPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQGLLCCARRAARRRHATHGCLARPGPPPSPG >ACM2_RAT --------------MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVSRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VE-DGECYIQ------FFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >AG22_MERUN AATSRNITSSLPFVNLNMSGTNDLIFNCSHKPSDKHLEAIPVLYYLIFVIGFAVNIIVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRT-LG--NACVMAFPPEKYAQWSAGIALMKNVLGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALSWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSMFRVPITWLQGKRETMSREMDTFVS---- >NY5R_PIG -------------NTVATRNSGFPVWEDYKGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMRKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVTVLVSTLILISIAIVRYHMIKHPV-SNNLTANHGYFLIATVWTLGLAICSPLPVFHSLVESS--RYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRTISCGVPESRSIMRLRKRSRSVFYRLTVLILVFAVSWMPLHLFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLMSLIHCLHVS--------------------- >CB1R_HUMAN EFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHR-KDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCE-K--LQSVCSDI------FPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGKHANNAASVHRA >D3DR_MOUSE --------MAPLSQISSHINSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN---D-P--SICSI---------SNPDFVIYSSVVSFYVPFGVTVLVYARIYMVLRQRTSLPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------- >GPRF_MACMU ----MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPLKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKLLAIVSGLQAMLQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFT >CB1R_RAT EFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCK-K--LQSVCSDI------FPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGHANNTASMHRAA >CKR4_HUMAN IADTTLDESIYSNYYLYESIPKPC---TKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQ--WVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT-ER-HTYCKTK-YSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTL---------QHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLTP------SSSY >PD2R_MOUSE ----------------------MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQ-MIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMAQSYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKL--AEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQL----------- >OPSD_BUFMA MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLCAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTVTMYSSMNGYFVFGQTGCYVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFSENHAIMGVAFTWIMALACAAPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVFFLICWVPYASVAFFIFTHQGSEFGPVFMTIPAFFAKSSSIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDEDASSAASSVSSSQVSPA >5H1F_MOUSE -------------MDFLNASD-QNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVYARKRTPRHAGIMITIVWVISVFISMPPLFWR----S-R--DECVIK-------HDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLLKHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRY----------------------- >B2AR_RAT MEPHGNDSDFLLAPNGSRAPGH----DITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-D--TCCDFF--------TNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQGRSLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANL-IPKEVYILLNWLGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSSKTYGNGYSDYTGEQSAYQLG >O.YR_PIG GVLAANWSAEAVNSSAAPPEAEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RALRRPADRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDADA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSSSHLKTSRPGENSSTFVLSQHSS >OPSB_CARAU PEFHEDFYIPIPLDINNLSAYSPFLVPQDHLGNQGIFMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFVAIFGSPLSFYSFFNRYFIFGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGNFTFKTPHAIAGCILPWISALAASLPPLFGWSRYIPEGLQCSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSASTQKAEREVTKMVVVMVLGFLVCWAPYASFSLWIVSHRGEEFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMMKMVCGKNIEE---DEASTSSVAPEK----- >5H1B_RAT CAPPPPATSQTGVPLANLSHNSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPKRAAIMIVLVWVFSISISLPPFFWR----E-E--LDCFVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG--------------------- >H963_HUMAN -----------------------MTNSSFFCPVYKDLEPFTYFFYLVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCIYRIQEPGFAKMISTVVWLMVLLIMVPNMMIPIKD-SN---VGCMEF--KKEFGRNWHLLTNFICVAIFLNFSAIILISNCLVIRQLYR-----NKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRSKVTETFASPKETKAQKEKLRC------------ >OPS3_DROME ARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVKTPIFIYNSFHQG-YALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPM-EGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFPEGYLTSCTFD--YLTDNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHNVESNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLALNEKAPESSAVEPQQTTAA---- >CCR5_MOUSE DDLYKELAFYSNSTEIPLQDSNFCSTVEGPLLTSFKAVFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLLVFILPFAVAEGSVG--WVLGTFLCKTVIALHKINFYCSSLLVACIAVDRYLAIVHAVAYRRRRLLSIHITCTAIWLAGFLFALPELLFAKVGQ-ND-LPQCTFSQENEAETRAWFTSRFLYHIGGFLLPMLVMGWCYVGVVHRL--------LQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLERLKGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCAG---PASLC--------PNWR >5H1F_CAVPO -------------MDFLNSSD-QNLTSEELLHRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVYARKRTPKQAGIMITIVWIISVFISMPPLFWR----S-R--DECIIK-------HDHIVSTIYSTFGAFYIPLVLILILYYKIYKAAKTLLRHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMANFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCQY----------------------- >OPSD_MESBI MNGTEGLNFYVPFSNHTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVANLFMVLGGFTTTLYTSMHAYFIFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWIMALACAAPPLVGWSRYIPEGMQCSCGVDYYTPSPEVNNESFVVYMFVVHFSIPMVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVVIMVVAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPSFFAKSSAIYNPVIYIMMNKQFRNCMLTTLCCGRNPLGDDEVSTTASKTETSQVAPA >PI2R_RAT GRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYYAQLDGPRCARLALPAIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIR---MRSPQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLCHMRRHFVPTSRAREDEVYHLILLALMTGIMAVCSLPLTIRGFTQAIAPDS--REMGDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQTPRRDTLAPDSLQA >IL8A_PANTR PQMWDFDDLNFTGMPPTDEGYSPC----RLETETLNKYVVIITYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYH-NS-SPVCYEV-LGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHR------------ >CCR5_HUMAN EDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVG--WVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQ-NN-LPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRL--------RQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTG---PASLC--------PSWR >CB2R_HUMAN ----MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHG-VDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTC-----CPRPCSEL------FPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHSGHQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKVTETEADGKITP >AA2B_HUMAN ------------------------------MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLG--FCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDT-T-LVKCLFE-----NVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQ---MDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGLGVGL------- >MSHR_HUMAN AVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGTNVLETAVILLLEAAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALYHSIVTLPRAPRAVAAIWVASVVFSTLFIAYYY----------------------DDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHIARKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW----------------------- >ETBR_PIG SSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITRI--LRICLLHQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFE-EKQSLEFKANDHGYDNFR >OAR2_LOCMI SSAAEEPQDALVGGDACGGRRPPSVLGVRLAVPEWEVAVTAVSLSLIILITIVGNVLVVLSVFTYKPLRIVQNFFIVSLAVADLTVAVLVMPFNVAYSLIQRWVFGIVVCKMWLTCDVLCCTASILNLCAIALDRYWAITDPIYAQKRTLRRVLAMIAGVWLLSGVISSPPLIGWNDW-N-D--TPCQLT--------EEQGYVIYSSLGSFFIPLFIMTIVYVEIFIATKRRPVYEEKQRISLSKERRAARTLGIIMGVFVVCWLPFFLMYVIVPFCNPSKPSPKLVNFITWLGYINSALNPIIYTIFNLDFRRAFKKLLHFKT----------------------- >MC5R_HUMAN -MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNDAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALYHHIMTARRSGAIIAGIWAFCTGCGIVFILYYS----------------------EESTYVILCLISMFFAMLFLLVSLYIHMFLLARTH-RIPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD------------ >5H6_RAT -----------MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPARNTS-NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLYKLRMTAPRALALILGAWSLAALASFLPLLLGWH---E-APGQCRLL--------ASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQMESRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPAVPDQASACSRC >5H1D_CAVPO SPPNQSEEGLPQEASNRSLNATETPGDWDPGLLQALKVSLVVVLSIITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAGAMIAAVWVISICISIPPLFWR----Q-E--SDCLVN-------TSQISYTIYSTCGAFYIPSVLLIILYSRIYRAARSRKLALERKRISAARERKATKTLGIILGAFIVCWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQKVVHFRKAS--------------------- >NMBR_MOUSE SNLSFPTEANESELVPEVWEKDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLTNSAMRNVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMMQTSGVLLWTSLKAVGIWVVSVLLAVPEAVFSEVARSS--FTACIPY---QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIKSLPGNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHVLYLYRSFNYKELGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGRKSYPERSTSYLMTSLKSNTKNVV >OPSD_SHEEP MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPQGMQCSCGALYFTLKPEINNESFVIYMFVVHFSIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQFRNCMLTTLCCGKNPLGDDEASTTVSKTETSQVAPA >OPSD_GALML MNGTEGENFYVPMSNKTGVVRNPFEYPQYYLADHWMFAVLAAYMFFLIITGFPVNFLTLFVTIQNKKLRQPLNYILLNLAVANLFMVFGGFTTTLITSMNGYFVFGSTGCNLEGFFATLGGEISLWSLVVLAIERYVVVCKPMSNFRFGSQHAIAGVSLTWVMAMACAAPPLVGWSRYIPEGLQCSCGIDYYTPKPEINNVSFVIYMFVVHFSIPLTIIFFCYGRLVCTVKAAAAQQQESETTQRAEREVTRMVVIMVIGFLICWLPYASVALYIFNNQGSEFGPVFMTIPSFFAKSSALYNPLIYILMNKQFRNCMITTLCCGKNPFEEEESTSASSVSSSQVSPAA >A1AA_RAT ----------MVLLSENASEGSNCT-HPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKREAKNFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALSQ---------- >GHSR_RAT SEEPEP-NVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVG---T-D-TNECRAT---FAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRD--AVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDKSSINT------ >O1E2_HUMAN -------------MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPVYLFLSNLSFSDLCFSSVTMPKLLQNMQNQDPSIPYADCLTQMYFFLYFSDLESFLLVAMAYDRYVAICFPMYTAIMSPMLCLSVVALSWVLTTFHAMLHTLLMARL---CPHFFCDMSKLACSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSI--------LKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCPSANS---STLKDTVMAMMYTVVTPMLTPFIYSLRNRDMKGALERVICKRKNPFLL------------------ >OPSD_SARSL MNGTEGPYFYVPMVNTSGIVRSPYEYPQYYLVNPAAYARLGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWLMALACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFTVPLMVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIMMVVAFLVCWLPYASVAWWIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >DOP2_DROME SATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARP----YKCTFT--------EHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQMGKLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTFATRRCYSTCSL >GASR_RABIT VASLCRPGGPLLNNSGTGNLSCEPPRIRGAGTRELELAIRVTLYAVIFLMSVGGNILIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTAVQP---V-LQCVHR---WPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGSGPPRPAQAKLLAKKRVVRMLLVIVVLFFMCWLPVYSANTWRAFDGPGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPSIASLSRLSYT >IL8B_CANFA G--DIDNYTYNTEMPIIPADSAPC----RPESLDINKYAVVVIYVLVFVLNLLGNSLVIMVVLYSRVSHSVTDVYLLNLAIADLLFALTLPIWAVSKVKG--WIFGTPLCKIVSLLKEVNFYSGILLLASISMDRYLAIVHATRRLTQKKHWVKFICLGIWALSLILSLPIFVFRRAIN-YS-SPVCYED-MGTNTTKLRIVMRALPQTFGFIVPLMIMLFCYGLTLRTL---------FEAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVADTLMRLQAINDIGRALDATEILGFFHSCLNPLIYAFIGQKFRHGLLKIMAFHGLISKEYLPKDS------------ >KI01_RAT ---------------MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPS-SKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQS-TN---IQCMEL--KNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFK----LKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS-------------------------------- >O18793 RSRFIRNTNGSGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSLTDIYLLNLAISDLLFLITLPLWAHSAANE--WVFGNAMCKLFTGLYHIGYLGGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQE-ED-VYICGPY----FPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWTPYNIVILLNTFQEFFRQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSMFFRKYITKRFCKQCPVFVTSTNTPSTAEQ >NY1R_HUMAN TLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDKD--KYVCFDQ---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >B2AR_FELCA ----MGQPGNRSVFLLAPNGSHAPDQDGTQERNDAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRAI-N--TCCDFF--------TNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQDGRHRRASKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-IPKEVYILLNWVGYVNSAFNPLIYCRSP-DFRIAFQELLCLRRSSLKAYGNGYSDYAGEHSGGPLG >OLF1_RAT -------------MTEENQTVISQFLLLFLPIPSEHQHVFYALFLSMYLTTVLGNLIIIILIHLDSHLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSIPFAGCLTQLYFYLYFADLESFLLVAMAYDRYVAICFPLYMSIMSPKLCVSLVVLSWVLTTFHAMLHTLLMARL---SPHFFCDISKLSCSDTHVNELVIFVMGGLVIVIPFVLIIVSYARVVASI--------LKVPSVRGIHKIFSTCGSHLSVVSLFYGTIIGLYLCPSANN---STVKETVMAMMYTVVTPMLNPFIYSLRNRDMKEALIRVLCKKKITFCL------------------ >GASR_HUMAN GASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQP---V-LQCVHR---WPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGPGPSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPSIASLSRLSYT >CKR2_MOUSE FTRSIQELDEGATTPYDYDDGEPC---HKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQ-DD-HYTCGPY----FTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFV-------SSTF >CKRA_MOUSE PTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTRSPTSVHLLQLALADLLLALTLPFAAAGALQG--WNLGSTTCRAISGLYSASFHAGFLFLACINADRYVAIARALGQRPSTPSRAHLVSVFVWLLSLFLALPALLFS--RD-RE-QRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTL---------LAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCSCSAPTETHSLS >OPSD_GOBNI MNGTEGPFFYIPMVNTTGVVRSPYEYPQYYLVNPAAYACLGAYMFFLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMASACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFTVHFCIPLAVVGFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVIGFLVCWLPYASVAWYIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTVSSSSVSPAA-- >AG2R_PIG ------MILNSSTEDSIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFH-YESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSE-------N >BONZ_MACMU -----MAEYDHYEDDGFLNSFNDSSQEEHQDFLQFRKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WIFGQVMCKTLLGVYTINFYTSMLILTCITVDRFIVVVKATNQQAKRMTWGKVICLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DEEISTVVLATQMTLGFFLPLLAMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQTPFNLVKLIRSTHWEYTSFHYTIIVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >PE24_RABIT --------------------MSTPVANASASSMPELLNNPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSRLQFPDTWCFID---WRTNVTAHAAFSYMYAGFSSFLILATVLCNVLVCGALLRMAAAAASFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPDEISQNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRDRSRRTSSAMSTHSR >FSHR_MACFA FDMTYAEFDYDLCNEVVDVTCSPKPDAFNPCEDILGYNILRVLIWFISILAITGNIIVLVTLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLDCKVHVRHAASVMVMGWIFAFAAALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTNSHPRNGHCSSA >ACM1_DROME -------------MYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGTISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIINFDRYFSVTRPLYRAKGTTNRAAVMIG-AWGISLLLWPPWIYSWPYIE-VP-KDECYIQ-----FIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRNPNKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSCIPTELWDFFYALCYINSTINPMSYALCNATFRRTYVRILTCKWHTRNREGMVRG------------ >BRS3_MOUSE QTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTVT--FESCNSY---ISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSIPTQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIMGRVPATGSAHV >OPSD_MUGCE MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAVERWMVVCKPISNFRFGENHAIMGLAFTWVMASACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLICWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >C5AR_HUMAN SFNYTTPDYGHYDDKDTLDLNTPVD--KTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAK-RTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPICQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVRE-PP--VLCGVD-YS-HDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRT---------WSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSLLLNKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRSTVD-------- >MAS_RAT ------MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMR-RNPFTVYITHLSIADISLLFCIFILSIDYALDYESSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCI-DSHS--QSDC-----------RAVIIFIAILSFLVFTPLMLVSSTILVVKIRK----------NTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYW--STFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRTVSIETVV---- >GPRC_RAT NLSGLPRDCIEAGTPENISAAVPSQGSVVESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAG-LGLIINFVFA-Y--LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALYHSERTVTFTYVMLVMLWGTSTCLGLLPVMGWNCL-R--DESTCSVV-------RPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHIALHFLATSHYVTTRKGISTLALILGTFAACWMPFTLYSLIADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPNTLSQRARSP------------ >V1AR_HUMAN SSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIETK--ARDCWAT---FIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNFLLVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTTFYSNNRSPTNS >A1AA_HUMAN ----------MVFLSGNASDSSNCT-QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKREAKTFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALSQ---------- >CML2_RAT PSNSTPLALNLSLALREDAPGNLTGDLSEHQQYVIALFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAAADLILVADSLIEVFNLDEQ--YYDIAVLCTFMSLFLQINMYSSVFFLTWMSFDRYLALAKAMCGLFRTKHHARLSCGLIWMASVSATLVPFTAVHLR-A----CFCFA---------DVREVQWLEVTLGFIVPFAIIGLCYSLIVRALIR----AHRHRGLRPRRQKALRMIFAVVLVFFICWLPENVFISVHLLQWAQHAYPLTGHIVNLAAFSNSCLSPLIYSFLGETFRDKLRLYVAQKTSLPALNRFCHADSTEQSDVKFSS >GPRF_HUMAN ----MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPIKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFA >CKR5_TRAFR ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >GP68_HUMAN ----------------MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEV--QH---RVCFEHPIQAWQRAIQRAINYYRFLVGFLFPICLLLASYQGILRAVRR------SHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAAPEASGKSGAQG >YYI3_CAEEL SDPNAEDLYITMTPSVSTENDTTVWATEEPAAIVWRHPLLAIALFSICLLTVAGNCLVVIAVCTKKYIWVTRLYLIISLAIADLIVGVIVMPMNSLFEIANHWLFGLMMCDVFHAMDILASTASIWNLCVISLDRYMAGQDPIYRDKVSKRRILMAILSVWVLSAILSFPGIIWWWRTSP-H--SQCLFT--------DSKMYVSFSSLVSFYIPLFLILFAYGKVYIIATRHKLNKSRQMMRYVHEQRAARTLSIVVGAFILCWTPFFVFTPLTAFCESCSNKETIFTFVTWAGHLNSMLNPLIYSRFSRDFRRAFKQILTCQRQQKVKTAFKTPLISVTQMAPRFS >CKR1_MACMU METPNTTEDYDMITEFDYGDATPC---HKVNERAILAQLLPPLYSLVFVIGVVGNLLVVLVLVQYKRLKNMTNIYLLNLAISDLLFLFTLPFLIYYKSTDD-WIFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIIIWALAILASSPLMYFSKTQW-NI-RHSCNIHFPYESFQQWKLFQALKLNLFGLVLPLLVMIVCYTGIIKIL---------LRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTELISVFQEFLRQLDLAMEVTEVIANMHCCVNPVIYAFAGERFRKYLRQLFHRRVAVHLVKWLPFLV-------SSTS >BRB2_RAT IEMFNITTQALGSAHNGTFSEVNC---PDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKD-HN--TACVIV---YPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNN---EMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGRAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQLRTS-------I >A1AD_RAT TGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEP--VP--RFCGIT--------EEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTHTLLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR--LWAASTGD-ARSDCA >TSHR_BOVIN LQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNP------HYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGSTGIRVQKVPPD >MC3R_HUMAN NASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEIFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYYS----------------------EESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHIAAADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG------------------ >MSHR_SHEEP PVLGSQRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSVLSITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >CKR1_MOUSE MEISDFTEAYPTTTEFDYGDSTPC---QKTAVRAFGAGLLPPLYSLVFIIGVVGNVLMILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDD-WIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVALRARTVTLGIITSIITWALAILASMPALYFFKAQW-EF-HRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRIL---------LRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLKHLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLT-------SSIS >A2AA_BOVIN ----MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRP-S--PRCEIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRSGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCP--VPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >SSR3_MOUSE SEPMTLDPGNTSSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTSARWRTAPVARTVSRAVWVASAVVVLPVVVFSGVPR-----STCHMQ-WPEPAAAWRTAFIIYMAALGFFGPLLVICLCYLLIVVKVRSTSCQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGEEDEEEEERREE >P2YR_BOVIN TAFLADPGSPWGNSTVTSTAAVASPFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAVYISVLVWLIVVVGISPILFYSGTG----KTITCYDT-TSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLSEFKQNGDTSL >5H5B_RAT TPGIAFPPGPESCSDSPSSGRGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLYTLRTRRRASALMIAITWALSALIALAPLLFGWGE-D-A-LQRCQVS--------QEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRATVTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCAC-SLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR----------------------- >OPSD_CHICK MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLGGEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSRYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQFRNCMITTLCCGKNPLGDEDTSAGTSSVSTSQVSPA >B3AR_MOUSE MAPWPHRNGSLALWSDAPTLDPSAAN---TSGLPGVPWAAALAGALLALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVQ-E--RCCSFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQGVPRRPARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPS-VPSGVFIALNWLGYANSAFNPVIYCRSP-DFRDAFRRLLCSYGGRGPEEPRAVTARQSPPLNRFDG >SSR1_RAT GEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAADG--TVACNML-MPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQ--DDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLS-----WMDNAAETALKSRAYSVED >AA1R_HUMAN ----------------------------MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPID--PDD--------- >PE23_HUMAN PFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHYASHMKTRATRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCWSDHLER----- >OLF0_RAT ---------------MNNQTFITQFLLLGLPIPEEHQHLFYALFLVMYLTTILGNLLIIVLVQLDSQLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMRSQDTSIPYGGCLAQTYFFMVFGDMESFLLVAMAYDRYVAICFPLYTSIMSPKLCTCLVLLLWMLTTSHAMMHTLLAARL---SLNFFCDLFKLACSDTYINELMIFIMSTLLIIIPFFLIVMSYARIISSI--------LKVPSTQGICKVFSTCGSHLSVVSLFYGTIIGLYLCPAGNN---STVKEMVMAMMYTVVTPMLNPFIYSLRNRDMKRALIRVICSMKITL-------------------- >BRB2_RABIT -MLNITSQVLAPALNGSVSQSSGC---PNTEWSGWLNVIQAPFLWVLFVLATLENLFVLSVFCLHKSSCTVAEVYLGNLAAADLILACGLPFWAVTIANHFDWLFGEALCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMIGRMRRVRWAKLYSLVIWGCTLLLSSPMLVFRTMKD-YN--TACIID---YPSRSWEVFTNVLLNLVGFLLPLSVITFCTVQILQVLRNN---EMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQVSTFLDTLLKLGHVIDVITQVGSFMGYSNSCLNPLVYVIVGKRFRKKSREVYRAACPKAGCVLEPVQLRTS-------I >CCKR_MOUSE DSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTANMCRFL---LPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGRINSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVTIRASLSRYSYS >ACM3_RAT N---------ISQETGNFSS-NDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQHKRVPEQAL--- >5H1E_HUMAN -------------MNITNCT--TEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIYARKRTAKRAALMILTVWTISIFISMPPLFWRS---S-P--SQCTIQ-------HDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLNDLGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYT-VSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT--------------------- >OPS1_CALVI ALT---NGSVTDKVTPDMAHLVHPYWNQFPAMEPKWAKFLAAYMVLIATISWCGNGVVIYIFSTTKSLRTPANLLVINLAISDFGIMITNTPMMGINLFYETWVLGPLMCDIYGGLGSAFGCSSILSMCMISLDRYNVIVKGMAGQPMTIKLAIMKIALIWFMASIWTLAPVFGWSRYVPEGNLTSCGID--YLERDWNPRSYLIFYSIFVYYLPLFLICYSYWFIIAAVSAHMNVRSSEDADKSAEGKLAKVALVTISLWFMAWTPYTIINTLGLFKYEG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYGIALKEKCPCCVFGKVDDGK-ASNNESETKA---- >V1BR_RAT ---MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLGRHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLRESG--VLDCWAD---FYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNRGLVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENADSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGSKPQVHRQLSRTTLLTHACGSP >OPSD_SARPI MNGTEGPFFYIPMSNATGLVRSPYDYPQYYLVPPWGYACLAAYMFLLILTGFPVNFLTLYVTIEHKKLRSPLNYILLNLAVADLFMVIGGFTTTMWTSLNGYFVFGRMGCNIEGFFATLGGEIALWSLVVLSMERWIVVCKPISNFRFGENHAVMGVAFSWFMAAACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVVHFTCPLTIITFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVIIMFVAFLACWVPYASVAWYIFTHQGSEFGPVFMTIPAFFAKSSAVYNPVIYICLNKQFRHCMITTLCCGKNPFEEEEGSTTSVCSVSPAA--- >V1BR_MOUSE ---MDSEPSWTATPSPGGTLFVPNTTTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLILGLQGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPSQSTYPLIAAPWLLAAILSLPQVFIFSLRESG--VLDCWAD---FYFSWGPRAYITWTTMAIFVLPVVVLTACYGLICHEIYKNATLVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENADSTNVAFTISMLLGNLSSCCNPWIYMGFNSHLLPRSLSHRACCRGSKPRVHRQLSRTTLLTHTCGPS >CCKR_CAVPO DSLFVNGSNITSACELGFENETLFCLDRPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPSLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTGNMCRFL---LPNDVMQQTWHTFLLLILFLIPGIVMMVAYGLISLELYQGRINSSSSTANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGTPGVRGEMTTGASLSRYSYS >OPRM_RAT LSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVPSTANTVDRTNH >FMLR_RABIT -----------MDSNASLPLNVSGGTQATPAGLVVLDVFSYLILVVTFVLGVLGNGLVIWVTGFRMT-HTVTTISYLNLALADFSFTSTLPFFIVTKALGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCICVLHPVAQNHRNVSLAKKVIVGPWICALLLTLPVIIRVTTLSSPWPAEKLKVA------ISMFMVRGIIRFIIGFSTPMSIVAVCYGLIATKI---------HRQGLIKSSRPLRVLSFVVASFLLCWSPYQIAALIATVRIREKDLRIVLDVTSFVAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALSEDSAQTTS---------- >OPSP_COLLI ----MDPTNSPQEPPHTSTPGPFDGPQWPHQAPRGMYLSVAVLMGIVVISASVVNGLVIVVSIRYKKLRSPLNYILVNLAMADLLVTLCGSSVSFSNNINGFFVFGKRLCELEGFMVSLTGIVGLWSLAILALERYVVVCRPLGDFRFQHRHAVTGCAFTWVWSLLWTTPPLLGWSSYVPEGLRTSCGPN--WYTGGSNNNSYILTLFVTCFVMPLSLILFSYANLLMTLRAAAAQQQESDTTQQAERQVTRMVVAMVMAFLICWLPYTTFALVVATNKDIAIQPALASLPSYFSKTATVYNPIIYVFMNKQFQSCLLKMLCCGHHPRGTGRTAPAGLRNKVTPSHPV >O1D2_HUMAN -------------MDGGNQSEGSEFLLLGMSESPEQQQILFWMFLSMYLVTVVGNVLIILAISSDSRLHTPVYFFLANLSFTDLFFVTNTIPKMLVNLQSHNKAISYAGCLTQLYFLVSLVALDNLILAVMAYDRYVAICCPLYTTAMSPKLCILLLSLCWVLSVLYGLIHTLLMTRV---THYIFCEMYRMACSNIQINHTVLIATGCFIFLIPFGFVIISYVLIIRAI--------LRIPSVSKKYKAFSTCASHLGAVSLFYGTLCMVYLKPLHTY----SVKDSVATVMYAVVTPMMNPFIYSLRNKDMHGALGRLLDKHFKRLT------------------- >IL8A_HUMAN PQMWDFDDLNFTGMPPADEDYSPC----MLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYH-NS-SPVCYEV-LGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHR------------ >EBP2_HUMAN NPDKDGGTPDSGQELRGNLTGQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQM----KPSASLSLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPRKS-CRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTEQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASKLKTEVSSSIYF >5H5B_MOUSE TPGLAFPPGPESCSDSPSSGRGGLILPGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAVLVMPLSLVSELSAGWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLYTLRTRSRASALMIAITWALSALIALAPLLFGWGE-D-A-LQRCQVS--------QEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRATVTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELISPLCAC-SLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR----------------------- >V2R_BOVIN MFMASTTSAVPWHLSQPTPAGNGSEGELLTARDPLLAQAELALLSTVFVAVALSNGLVLGALVRRGRRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAHRHGGGTHWNRPVLLAWAFSLLFSLPQLFIFAQRDSG--VLDCWAR---FAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASGCRPAEGARVSAAVAKTVKMTLVIVIVYVLCWAPFFLVQLWAAWDPEA-REGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCTWRRAPPSPGPQESFLAKDTPS--- >GRHR_MOUSE --MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPL-AVQSNSKLEQSMISLAWILSIVFAGPQLYIFRMIYTV--FSQCVTH--SFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVPRKNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >OLF1_CANFA --------------MDGNYTLVTEFILLGFPTRPELQIVLFLVFLTLYGIILTGNIGLMMLIRTDPHLQTPMYFFLSNLSFADLCFSSAIVPKMLVNFLSENKSISLYGCALQFYFSCAFADTESFILAAMAYDRYVAICNPLYTVVMSRGICVWLIVLSYIGGNMSSLVHTSFAFIL---KNHFFCDLPKLSCTDTSVNEWLLSTYGSSVEIFCFIVIVISYYFILRSV--------LRIRSSSGRKKTFSTCASHLTSVAIYQGTLLFIYSRPTYLY---TPNTDKIISVFYTIIIPVLNPLIYSLRNKDVKDAAKRAVRLKVDSS-------------------- >GPRY_HUMAN SVSSWPYSSHRMRFITNHSDQATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKK-----STMCFHY--RDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKR--SKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSLHDTSVAVKIQS >OPSD_RANPI MNGTEGPNFYIPMSNKTGVVRSPFDYPQYYLAEPWKYSVLAAYMFLLILLGLPINFMTLYVTIQHKKLRTPLNYILLNLGVCNHFMVLCGFTITMYTSLHGYFVFGQTGCYFEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIISFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWVPYAYVAFYIFTHQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDDDASSAATSVSTSQVSPA >GP38_HUMAN GSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLARVLVTRRRVRALIAVLWAVALLSAGPFLFLVG---AEAFSRECRPS----PAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSPLR--AASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDDTGGDTVGYTET >GPRM_HUMAN PILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPA-NRILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFS--TKTLLCVST---EYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRTISQHEARERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNWIDPKRNKKITF >GPR3_HUMAN GAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAG-LGLVLHFAAV-F--CIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCL-D--GLTTCGVV-------YPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHIALHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDA----HSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSP------------ >CCKR_RAT DSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLSRVWQTKSHALKVIAATWCLSFTIMTPYPIYN----NNQTANMCRFL---LPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGRLNSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVTIRALLSRYSYS >RDC1_MOUSE YAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITTPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTTSSYKKKMVRRVVCILVWLLAFFVSLPDTYYLKAVTNNE--TYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAM---------SASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHNVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNTK-- >OLF9_RAT -------------MTRRNQTAISQFFLLGLPFPPEYQHLFYALFLAMYLTTLLGNLIIIILILLDSHLHTPMYLFLSNLSFADLCFSSVTMPKLLQNMQSQVPSIPYAGCLAQIYFFLFFGDLGNFLLVAMAYDRYVAICFPLYMSIMSPKLCVSLVVLSWVLTTFHAMLHTLLMARL---SPHYFCDMSKVACSDTHDNELAIFILGGPIVVLPFLLIIVSYARIVSSI--------FKVPSSQSIHKAFSTCGSHLSVVSLFYGTVIGLYLCPSANN---STVKETVMSLMYTMVTPMLNPFIYSLRNRDIKDALEKIMCKKQIPSFL------------------ >5H1D_RABIT SPSNQSAEGLPQEAANRSLNATGTPEAWDPGTLQALKISLAVVLSIITVATVLSNTFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQVLCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAAAMIAVVWAISICISIPPLFWR----H-E--SDCLVN-------TSQISYTIYSTCGAFYIPSVLLIVLYGRIYMAARNRKLALERKRISAARERKATKTLGIILGAFIGCWLPFFVASLVLPICRDSWMPPGLFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQRVIHFRKAF--------------------- >ML1C_.ENLA -----MMEVNSTCLDCRTPGTIRTEQDAQDSASQGLTSALAVVLIFTIVVDVLGNILVILSVLRNKKLQNAGNLFVVSLSIADLVVAVYPYPVILIAIFQNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLYDKLYNQRSTWCYLGLTWILTIIAIVPNFFVGS-LQYDP-IFSCTFA------QTVSSSYTITVVVVHFIVPLSVVTFCYLRIWVLVIQVHR-QDFKQKLTQTDLRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPFHKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEYKRILMSLLTPRLLFLDTSRSKPSPAVTNNNQ >SSR2_PIG LLNGSQPWLSSPFDLNGSVATANSSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDLNETTETQRTLL >NTR1_HUMAN EEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFAKTLMSRSRTKKFISAIWLASALLTVPMLFTMGEQN--SGGLVCTPT---IHTATVKVVIQVN-TFMSFIFPMVVISVLNTIIANKLTVMEHSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRK-RPSVSSNHTLSSNA >AG2R_CAVPO ------MILNSSTEDGIKRIQDDC---PKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTRPSD-------N >PE23_RABIT PFCTRLNHSYPGMWAP----EARGNLTRPPGPGEDCGSVSVAFPITMLITGFVGNALAMLLVSRSYRRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSKQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHYASHMKTRATRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNGTSSSHNWGNLFFASTFAFLGLLALAITFTCNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVIHENNEQKDEIQRENRHEEARDSEKSKT >CB1A_FUGRU TDLFGNRNTTRD-ENSIQCGENFMDMECFMILTPSQQLAVAVLSLTLGTFTVLENLVVLCVIFQSRTRCRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHK-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYRRIVTRTKAVIAFCMMWTISIIIAVLPLLGWNCK-R--LNSVCSDI------FPLIDENYLMFWIGVTSVLVLFIIYAYIYILWKAHHHAEGQTTRPEQTRMDIRLAKTLVLILAVLVICWGPLLAIMVYDLFWKMDDNIKTVFAFCSMLCLLNSTVNPIIYALRSRDLRHAFLSSCHACRGSAQQLDNSLENVN--ISANRAA >CKR9_HUMAN DDYGSESTSSMEDYVNFNFTDFYC---EKNNVRQFASHFLPPLYWLVFIVGALGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLVTLPFWAIAAADQ--WKFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIAQAMTWREKRLLYSKMVCFTIWVLAAALCIPEILYSQIKE-G--IAICTMVYPSDESTKLKSAVLTLKVILGFFLPFVVMACCYTIIIHTL---------IQAKKSSKHKALKVTITVLTVFVLSQFPYNCILLVQTIDAYATNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFT--------GSLK >V1BR_HUMAN ---MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLRESG--VLDCWAD---FGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNRGLVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNADSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSHTTLLTRSSCPA >5H4_RAT ------------------MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIRK-NSTFCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHSRPDQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTINGSTHVLR-- >5HTA_DROME DSSLFGEMLANRSGHLDLINGTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNI-YIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDE-Q--QKCMVS--------QDVSYQVFATCCTFYVPLMVILALYWKIYQTARKRPMQKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL------------- >HH1R_CAVPO -MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFM--EP-EKKCETD------FYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHLRSQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSC-SNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP----------------------- >OPSD_PHOGR MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVGLTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGFNFGPIFMTLPAFFAKAAAIYNPVIYIMMNKQFRTCMITTLCCGKNPLGDDEVSASASKTETSQVAPA >MSHR_CANFA VWQGPQRRLLGSLNGTSPATPHFELAANQTGPRCLEVSIPNGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYY----------------------NNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQH-IAKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHGCVFQNFNLFLTLIICNSIIDPFIYAFRSQELRKTLQEVVLCSWA---------------------- >A2AC_HUMAN AAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKRRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFIYSLYGICREAQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRPSFKHILFRRRRRGFRQ----------------- >B1AR_SHEEP VPDGAATAARLLVP-SPLRLAADLGQRGTPLLSQQWTVGMGLLMAFIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPIFMQWWGDS-R--ECCDFI--------INEGYAITSSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACGSHGAAGCLAVARPSPSPG >OPS4_DROME S-GNGDLQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLKAPIFNSFHRGFA-IYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPM-NRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFPEGYLTSCSFD--YLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHNVESNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGVNEKSGEISSAQQQTTAA----- >O1E1_HUMAN -------------MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPMYLFLSNLSFSDLCFSSVTIPKLLQNMQNQDPSIPYADCLTQMYFFLLFGDLESFLLVAMAYDRYVAICFPLYTAIMSPMLCLALVALSWVLTTFHAMLHTLLMARL---CPHFFCDMSKLAFSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSI--------LKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCSSANS---STLKDTVMAMMYTVVTPMLNPFIYSLRNRDMKGALSRVIHQKKTFFSL------------------ >MSHR_CHICK -MSMLAPLRLVREPWNASEGNQSNATAGAGGAWCQGLDIPNELFLTLGLVSLVENLLVVAAILKNRNLHSPTYYFICCLAVSDMLVSVSNLAKTLFMLLMEHASIVRHMDNVIDMLICSSVVSSLSFLGVIAVDRYITIFYALYHSIMTLQRAVVTMASVWLASTVSSTVLITYYY----------------------RRNNAILLCLIGFFLFMLVLMLVLYIHMFALACHHSISQKQPTIYRTSSLKGAVTLTILLGVFFICWGPFFFHLILIVTCPTNTCFFSYFNLFLILIICNSVVDPLIYAFRSQELRRTLREVVLCSW----------------------- >A1AA_BOVIN ----------MVFLSGNASDSSNCT-HPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQP--AP--TICQIN--------EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKREAKNFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLSH---------- >CKR5_PYGBI ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCYIFA-------SSVY >OPSO_SALSA TLRIAVNGVSYNEASEIYKPHADPFTGPITNLAPWNFAVLATLMFVITSLSLFENFTVMLATYKFKQLRQPLNYIIVNLSLADFLVSLTGGTISFLTNARGYFFLGNWACVLEGFAVTYFGIVAMWSLAVLSFERYFVICRPLGNVRLRGKHAALGLLFVWTFSFIWTIPPVFGWCSYTVSKIGTTCEPN--WYSNNIWNHTYIITFFVTCFIMPLGMIIYCYGKLLQKLRKVSHD--RLGNAKKPERQVSRMVVVMIVAYLVGWTPYAAFSIIVTACPTIYLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQVSTQLNWGFWSRA----------------------- >NY1R_RAT TLFSRVENYSVHYNVSE-NSPFLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDKD--KYVCFDK---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMIRDSKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >OLF3_CANFA -------------MGTGNQTWVREFVLLGLSSDWDTEVSLFVLFLITYMVTVLGNFLIILLIRLDSRLHTPMYFFLTNLSLVDVSYATSIIPQMLAHLLAAHKAIPFVSCAAQLFFSLGLGGIEFVLLAVMAYDRYVAVCDPLYSVIMHGGLCTRLAITSWVSGSMNSLMQTVITFQL---PDHISCELLRLACVDTSSNEIAIMVSSIVLLMTPFCLVLLSYIQIISTI--------LKIQSTEGRKKAFHTCASHLTVVVLCYGMAIFTYIQPRSSP---SVLQEKLISLFYSVLTPMLNPMIYSVRNKEVKGAWQKLLGQLTGITSKLAT--------------- >P2Y9_HUMAN DRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRH-WPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTN----ATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKP----ATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQRFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTIQEEVSDQTTNN >MC5R_BOVIN -MNSSFHLHFLDLGLNTTDGNLSGLSVQNASSLCEDMGIAVEVFLALGLISLLENILVIGAIVRNRNLHTPMYFFVGSLAVADMLVSLSNSWETITIYLLTNDASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCALYQRIMTGRRSGAIIGGIWAFCASCGTVFIVYYY----------------------EESTYVVICLIAMFLTMLLLMASLYTHMFLLARTH-RIPGHSSVRQRTGVKGAITLAMLLGVFIVCWAPFFLHLILMISCPHNSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQSFRTPCRFPSRY------------ >CKR5_TRAPH ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OPSB_SAIBB --MSKMPEEEEFYLFKNISSVGPWDGPQYHIAPVWAFQLQAAFMGIVFLAGLPLNSMVLVATVRYKKLRHPLNYVLVNVSVGGFLLCIFSVLPVFVNSCNGYFVFGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALMVVLTTWTIGIGVSIPPFFGWSRYIAEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLICFSYAQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAALAMYMVNNRNHGLDLRLVSIPAFFSKSSCIYNPIIYCFMNKQFRACIMEMVCGKAMTD---ESDISSTVSSSQVGPN- >OAR_DROME LSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPIYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDW-T-S--TPCELT--------SQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRGVNEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN------------------------ >PAR3_HUMAN -WTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTR-SICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYY--D--TTCHDVNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTL----------NAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK-------------------------- >NMBR_HUMAN SNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARSS--FTACIPY---QTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSLPGNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNELGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLMTSLKSNAKNMV >AA1R_BOVIN ----------------------------MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PRTYFHTCLKVACPVLILTQSSILALLAMAVDRYLRVKIPLYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSN-G-VIECQFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPID--PDD--------- >C.C1_MOUSE ----------MESSTAFYDYHDKLSLLCENNVIFFSTISTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLISAQWS---WFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPITLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVIS-----LNCKYS------EHHGFLASVYQHNIFFLLSMGIILFCYVQILRTL---------FRTRSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKTGIIQQQQLDIAMIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTSSTVPCEGPSFY------ >OPS1_PATYE NGTLNRSMTPNTGWEGPYDMSVHLHWTQFPPVTEEWHYIIGVYITIVGLLGIMGNTTVVYIFSNTKSLRSPSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHQWIFGSLFCQLYGFVGGVFGLMSINTLTAISIDRYVVITKPLASQTMTRRKVHLMIVIVWVLSILLSIPPFFGWGAYIPEGFQTSCTFD--YLTKTARTRTYIVVLYLFGFLIPLIIIGVCYVLIIRGVRRHSMKARANNKRARSELRISKIAMTVTCLFIISWSPYAIIALIAQFGPAHWITPLVSELPMMLAKSSSMHNPVVYALSHPKFRKALYQRVPWLFCCCKPKEKADFRSVTRTESVNSD >5H2B_MOUSE ILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIANQCNTRATAFIKITVVWLISIGIAIPVPIKGIET-NP---VTCELT------KDRFGSFMVFGSLAAFFVPLTIMVVTYFLTIHTLQKKRRMGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKGNSMVENSKFFT >OPSG_HUMAN DSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDG-----SELVSSV--SSVSPA >ACM4_MOUSE ------MANFTPVNGSSANQSVRLVTTAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-VP-DNQCFIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR---------------- >AA1R_RAT ----------------------------MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPID--AED--------- >AA1R_CHICK ----------------------------MAQSVTAFQAAYISIEVLIALVSVPGNILVIWAVKMNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIG--PQTEFYSCLMMACPVLILTESSILALLAIAVDRYLRVKIPVYKSVVTPRRAAVAIACCWIVSFLVGLTPMFGWNNLNN-V-VIKCQFE-----TVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFNLIRTQK-VSNDPQKYYGKELKIAKSLALVLFLFALSWLPLHILNCITLFCPSCKTPHILTYIAIFLTHGNSAMNPIVYAFRIKKFRTAFLQIWNQYFCCKTNKSSS--VN---------- >P2YR_MELGA PELLAG-----------GWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTG----KTITCYDT-TADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSLTEYKQNGDTSL >GRE1_BALAM ----MEGPPLSPAPADNVTLNVSCGRPATLFDWADHRLISLLALAFLNLMVVAGNLLVVMAVFVHSKLRTVTNLFIVSLACADLLVGMLVLPFSATLEVLDVWLYGDVWCSVWLAVDVWMCTSSILNLCAISLDRYLAVSQPIYPSLMSTRRAKQLIAAVWVLSFVICFPPLVGWNDR-G-S--LTCELT--------NERGYVIYSALGSFFLPSTVMLFFYGRIYRTAVSTRVSVRHQARRFRMETKAAKTVGIIVGLFILCWLPFFVCYLVRGFCADC-VPPLLFSVFFWLGYCNSAVNPCVYALCSRDFRFAFSSILCKCVCRRGAMERRFRRSQTEEDCEVAD >TDA8_MOUSE ---------------------MAMNSMCIEEQRHLEHYLFPVVYIIVFIVSVPANIGSLCVSFLQAKKENELGIYLFSLSLSDLLYALTLPLWINYTWNKDNWTFSPTLCKGSVFFTYMNFYSSTAFLTCIALDRYLAVVYPLFSFLRTRRFAFITSLSIWILESFFNSMLLWKDETS-DKSNFTLCYDK---YPLEKWQINLNLFRTCMGYAIPLITIMICNHKVYRAV------RHNQATENSEKRRIIKLLASITLTFVLCFTPFHVMVLIRCVLERDWQTFTVYRVTVALTSLNCVADPILYCFVTETGRADMWNILKLCTRKHNRHQGKKRRDAVELEIID-- >MSHR_CEREL PVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVAIPDGLFLSLGLVSLVENVLVVAAIAKNRNLQSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >NY1R_MOUSE TLFSKVENHSIHYNASE-NSPLLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDKD--KYVCFDK---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMIRDSKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >GPR1_MACMU EDLEETLFEEFENYSYALDYYSLESDLEEKVQLGVVHWVSLVLYCLSFVLGIPGNAIVIWFTGFKWKKTVS-TLWFLNLAIADFIFLLFLPLYISYVVMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVSHRHRTLKNSLIVIIFIWLLASLIGGPALYFR--D--NN-HTLCYNNHDPDLTVIRHHVLTWVKFIVGYLFPLLTMSICYLCLIFKV---------KKRSILISSRHFWTILAVVVAFVVCWTPYHLFSIWELTIHHNHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGNSETKNLCLLET >ACM1_PIG ------------MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFIVTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >RTA_RAT EAHSTNQNKMCPGMSEALELYSRGFLTIEQIATLPPPAVTNYIFLLLCLCGLVGNGLVLWFFGFSIK-RTPFSIYFLHLASADGIYLFSKAVIALLNMGTFLGSFPDYVRRVSRIVGLCTFFAGVSLLPAISIERCVSVIFPMYWRRRPKRLSAGVCALLWLLSFLVTSIHNYFCM-FL---SGTACL-----------NMDISLGILLFFLFCPLMVLPCLALILHVE---------CRARRRQRSAKLNHVVLAIVSVFLVSSIYLGIDWFLFWVFQ--IPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAEPGNTVTMEMQCPSG >GP43_HUMAN ------------------------------MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNT--N--ITCYEN-FTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQP------LVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQR---KSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRG---------TAE >CKR1_HUMAN METPNTTEDYDTTTEFDYGDATPC---QKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDD-WVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIIIWALAILASMPGLYFSKTQW-EF-HHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKIL---------LRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLV-------SSTS >VK02_SPVKA YEYSTITDYYNTINNDITSSSVIKAFDNNCTFLEDTKYHIIVIHIILFLLGSIGNIFVVSLIAFKRN-KSITDIYILNLSMSDCIFVFQIPFIVYSKLDQ--WIFGNILCKIMSVLYYVGFFSNMFIITLMSIDRYFAIVHPIRQPYRTKRIGILMCCSAWLLSLILSSPVSKLYENIP--MDIYQCTLTENDSIIAFIKRLMQIEITILGFLIPIIIFVYCYYRIFTTV---------VRLRNRRKYKSIKIVLMIVVCSLICWIPLYIVLMIATIVSLYLNLAYAITFSETISLARCCINPIIYTLIGEHVRSRISSICSCIYRDNRIRKKLFSNII--------- >AA1R_CAVPO ----------------------------MPHSVSAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIASLAVADVAVGALVIPLAILINIG--PQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKTVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLSN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCHKPTILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPEPPID--VDD--------- >P2Y6_RAT -----------MERDNGTIQAPGLPPTTCVYREDFKRLLLPPVYSVVLVVGLPLNVCVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLWHKRGGRRAAWVVCGVVWLVVTAQCLPTAVFAATG-----RTVCYDL-SPPILSTRYLPYGMALTVIGFLLPFTALLACYCRMARRLCRQ---GPAGPVAQERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRSTETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQKLTAKWQRQRV--------------- >O2H3_HUMAN ---------------MDNQSSTPGFLLLGFSEHPGLGRTLFVDVITSYLLTLVGNTLIILLSALDTKLHSPMYFFLSNLSFLDLCFTTSCVPQMLANLWGPKKTISFLDCSVQIFIFLSLGTTECILMKVMAFDRYVAVCQPLYATIIHPRLCWQLASVAWVIGLVGSVVQTPSTLHL---PDDFVCEVPRLSCEDTSYNEIQVAVASVFILVVPLSLILVSYGAITWAV--------LRINSATAWRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPY---AQGRGKFFGLFYAVGTPSLNPLVYTLRNKEIKRALRRLLGKERDSRESWRAA-------------- >OPRK_MOUSE LPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVDVD-VIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVASMRDVGGMNKP >5HTB_DROME TTSNLSQIVWNRSVNGNGNSNDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNI-YNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDE-E--QHCMVS--------QDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRPHQKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARARSAKI------------- >OPR._HUMAN GSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGF-WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEE---IECLVE-IPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLL-SGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVALACKTSETVPR >VG74_KSHV LDDDESWNETLNMSGYDYSGNFSLEVSVCEMTTVVPYTWNVGILSLIFLINVLGNGLVTYIFCKHRS-RAGAIDILLLGICLNSLCLSISLLAEVLM--FLFNIISTGLCRLEIFFYYLYVYLDIFSVVCVSLVRYLLVAYSTSWPKKQSLGWVLTSAALLIALVLSGDACRHRSRVVD-PVKQAMCYEN---NMTADWRLHVRTVSVTAGFLLPLALLILFYALTWCVV---------RRTKLQARRKVRGVIVAVVLLFFVFCFPYHVLNLLDTLLRRRGLINVGLAVTSLLQALYSAVVPLIYSCLGSLFRQRMYGLFQSLRQSFMSGATT-------------- >PE22_MOUSE ---------------MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIALALLARRWRSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQLAPESHACTYFAFTMTFFSLATMLMLFAMALERYLSIGYPYYRRHLSRRGGLAVLPVIYGASLLFCSLPLLNYGEYVQYCPGTWCFIR--------HGRTAYLQLYATMLLLLIVAVLACNISVILNLIRMRGPRRGERTSMAEETDHLILLAIMTITFAICSLPFTIFAYMDETSS---LKEKWDLRALRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRTSLRTQEAQQTSSKQTDLCGQL-- >A1AD_RABIT GSGEDNRSSAGEPGGAGGGGEVNGTAAVGGLVVSAQSVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWAVALVVSMGPLLGWKEP--VP--RFCGIT--------EEVGYAVFSSLCSFYLPMAVIVVMYCRVYVVARSTHTFLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRASAGGGPHPDCA >OPSD_CRIGR MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVICKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVILMVVFFLICWFPYAGVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGKNILGDDEASATASKTETSQVAPA >AA1R_CANFA ----------------------------MPPAISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PRTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKTVVTPRRAAVAIAGCWILSFVVGLTPLFGWNRLGN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRRQK-VSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCRKPSILMYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPTPPVD--PHD--------- >DCDR_.ENLA ---------MENFSIFNVTVNVWHADLDVGNSDLSLRALTGLLLSLLILSTLLGNTLVCLAVIKFRHRSKVTNFFVISLAVSDLFVALLVMPWKAVTEVAGFWVFG-DFCDTWVAFDIMCSTASILNLCIISLDRYWAIASPFYERKMTQRVAFIMIGVAWTLSILISFIPVQLSWHKSEE-HTENCDSS--------LNRTYAISSSLISFYIPVVIMIGTYTRIYRIAQTQSSRENSLKTSFRKETKVLKTLSIIMGVFVFCWLPFFVLNCMIPFCHMNCVSETTFNIFVWFGWANSSLNPVIYAFNA-DFRKAFTTILGCNRFCSSNNVEAVNYHHDTTFQK--- >O.YR_BOVIN GAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLSRRTDRLAVLVTWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNRAIVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFVQMWSVWDADA-KEASPFIIAMLLASLNSCCNPWIYMLFTGHLFQELVQRFLCCSFRRLKGSRPGENSSTFVLSQYSS >YQNJ_CAEEL RDSVINASSAVSTTTLPPLDIPMTSMKPPSIIPTVELVLGTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVVTFLAGQWLLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPIYAQKRTTKFVCIVIVIVWILSMLISVPPIIGWNNW-M---EDSCGLS--------TEKAFVVFSAAGSFFLPLLVMVVVYVKIFISARQRNPTRKREKISVAKEKRAAKTIAVIIFVFSFCWLPFFVAYVIRPFCETCTLVQQVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKILCPKAVLEQRRRRMSA------------ >OPS2_PATYE ------------------MPFPLNRTDTALVISPSEFRIIGIFISICCIIGVLGNLLIIIVFAKRRSVRRPINFFVLNLAVSDLIVALLGYPMTAASAFSNRWIFDNIGCKIYAFLCFNSGVISIMTHAALSFCRYIIICQYGYRKKITQTTVLRTLFSIWSFAMFWTLSPLFGWSSYVIEVVPVSCSVN--WYGHGLGDVSYTISVIVAVYVFPLSIIVFSYGMILQEKVCGIRARYTPRFIQDIEQRVTFISFLMMAAFMVAWTPYAIMSALAIGSFN--VENSFAALPTLFAKASCAYNPFIYAFTNANFRDTVVEIMAPWTTRRVGVSTLPWRRRTSAVNTTDI >RGR_HUMAN ---------------------MAETSALPTGFGELEVLAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTRS---QLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLD--YSKGDRNFTSFLFTMSFFNFAMPLFITITSYSLME--------------QKLGKSGHLQVNTTLPARTLLLGWGPYAILYLYAVIADVTSISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK---------------- >PE23_PIG ------------MWAPERSAEEQGNLTRSLGSSEDCGSVSVVFPMTMLITGFVGNALAMLLVSQSYRRKKSFLLCIGWLALTDMVGQLLTSPVVIVLYLSHQLDPSGRLCTFFGLTMTAFGLSSLFIASAMAVERALAIRAPHYSSHMKTSATRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNETSSENNWGNIFFASAFSFLGLSALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKTIFNQTSQNECNFFLIAVRLASLNQILDPWVYLLLRKILLQKFCQAVSQKQREEAATLIFTHPGEARVLFSKSK >ACM1_MACMU ------------MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL--GQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >GPRF_CERAE ----MDPEETSVYLDYYYATSPNPDIRETHSHVPYTSVFLPVFYIAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVFLLTCMSVDRYLAIVCPVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELT-IDD-KPYCAEK----KATPLKLIWSLVALIFTFFVPLLSIVTCYCRIARKLCAH---YQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTSKLLAIVSGLQAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETALSTFIHAEDFT >NK3R_RAT -G--NFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATKIVIGSIWILAFLLAFPQCLYSK---GR---TLCYVQ--WPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGG--PCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSY----TTRFHPTRQSSL >CKR3_CERAE MTTSLYTVETFGPTSYDDDMGLLC---EKADVGALIAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVREHN-WVFSHGMCKVLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVALRARTVTFGVITSIVTWGLAVLVALPEFIFYGTEE-LF-ETLCSAIYPQDTVYSWRHFHTLKMTILCLALPLLVMAICYTGIIKTL---------LKCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILISTYQSILKHVDLVVLVTEVIAYSHCCVNPVIYAFVGERFRKYLRHFFHRHVLMHLGRYIPFLT-------SSVS >PE24_HUMAN --------------------MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFID---WTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMAAAASSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSEVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSQRTSSAMSGHSR >GPR4_PIG --------------------MGNGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLRLWAAYRQVRQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLFARLRRVKTAVAVSSVVWATELGANSVPLFHDEL--NH---TFCFEKPMEGWVAWMVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRG------SVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAVYLGERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLTSDKPQEMDTPLTSKRNSMA >PE23_BOVIN PFCTRFNHSDPGIWAAERAVEAPNNLTLPPEPSEDCGSVSVAFSMTMMITGFVGNALAITLVSKSYRRKKSFLLCIGWLALTDMVGQLLTSPVVIVLYLSHQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALATRAPHYSSHMKTSVTRAVLLGVWLAVLAFALLPVLGVG----QYTGTWCFISNGTNSRQNWGNVFFASAFAILGLSALVVTFACNLATIKALVSRAKASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNHTSQDECNFFLIAVRLASLNQILDPWVYLLLRKILLQKFCQLLKGHSYGLDTEGGTENNLYISNLSRFFI >OPSD_RANCA MNGTEGPNFYVPMSNKTGIVRSPFEYPQYYLAEPWKYSVLAAYMFLLILLGLPINFMTLYVTIQHKKLRTPLNYILLNLAFANHFMVLCGFTITMYTSLHGYFVFGQTGCYFEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAMMGVAFTWIMALACAVPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFLIPLIIISFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVVIMVIFFLICWVPYAYVAFYIFTHQGSEFGPIFMTVPAFFAKSSAIYNPVIYIMLNKQFRNCMITTLCCGKNPFGDEDASSAATSVSTSQVSPA >OPS6_DROME GR----NLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTD--YFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMKAVAAHNVANSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFESMH-LSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGKDDLTSDSRSESQA------- >OPRM_HUMAN LSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIPSTANTVDRTNH >AA2A_MOUSE ----------------------------------MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGMKAKGIIAICWVLSFAIGLTPMLGWNNCST-K-RVTCLFE-----DVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQESQGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGAHSTEGEQVSLR >OPSG_CAVPO DAYEDSTQASLFTYTNSNNTRGPFEGPNYHIAPRWVYHLTSAWMTIVVIASIFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIVFSWVWSAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCITPLSIIVLCYLHVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAYCLCWGPYAFFACFATANPGYSFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVEDSSELSSTSRSVSPAA------ >CCR4_CERTO IYTSDNYTEEMG-SGDYDSIKEPC---FREKNAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQKPRKLLAEKVVYVGVWIPALLLTIPGFIFASVSE-DD-RFICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >OPSB_ANOCA MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLGGQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSRYIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVREAAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTICCGKNPFGDEDVSSSVSSVSSSQVSPA >O1A2_HUMAN -------------MKKENQSFNLDFILLGVTSQQEQNNVFFVIFLCIYPITLTGNLLIILAICADIRLHNPMYFLLANLSLVDIIFSSVTIPKVLANHLLGSKFISFGGCLMQMYFMIALAKADSYTLAAMAYDRAVAISCPLYTTIMSPRSCILLIAGSWVIGNTSALPHTLLTASL---SANFYCDIMKLSCSDVVFFNVKMMYLGVGVFSLPLLCIIVSYVQVFSTV--------FQVPSTKSLFKAFCTCGSHLTVVFLYYGTTMGMYFRPLTSY----SPKDAVITVMYVAVTPALNPFIYSLRNWDMKAALQKLFSKRISS--------------------- >A2AC_MOUSE AEGPNGSDAGEWGSGGGANASGTDWVPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYR-------PQCGLN--------DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRRRAVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ----------------- >5H2C_RAT LLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD-VF--NTTCVL---------NDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQKKKPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKAKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIALSGRELNVNIY >OPRM_PIG FSHLEGNLSDPCIRNRTELGGSDSLCPPTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYGS---IDCALT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIPSTANTVDRTNH >B1AR_FELCA LPDGAATAARLLVPASPSASPLTPTSEGPAPLSQQWTAGIGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVMRGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCFARRAARGGHAAAGCLPGTRPPPSPG >BONZ_HUMAN ------MAEHDYHEDYGFSSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIYTINFYTSMLILTCITVDRFIVVVKATNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >CH23_HUMAN EDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN-SS--WPTHSQ-MDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------QRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK-FKVALFSRLVNALSEDTGHSFTKMSSMNERTS >TSHR_HUMAN LQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSY----KVSICLPM-----TETPLALAYIVFVLTLNIVAFVIVCCCHVKIYITVRNP------QYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGSTDIQVQKVTHD >GHSR_PIG SEEPGPNLTLPDLGWDAPPENDSLVEELLPLFPTPLLAGVTATCVALFVVGIAGNLLTMLVVSRFREMRTTTNLYLSSMAFSDLLIFLCMPLDLFRLWQYRPWNLGNLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVG---T-D-TNECRAT---FAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRGE-AVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSLEPQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFEPFSQRKLSTLKDESSINT------ >B1AR_RAT LPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAR-R--KCCDFV--------TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQNGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFQRLLCCARRAACRRRAAHGCLARAGPPPSPG >ACM2_CHICK -----------MNNSTYINSSSENVIALESPYKTIEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGIFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV-VP-DKDCYIQ------FFSNPAVTFGTAIAAFYLPVIIMTVLYWQISRASKSRVKMPAKKKPPPSREKKVTRTILAILLAFIITWTPYNVMVLINSFCASC-IPGTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR---------------- >GPRK_HUMAN ATAVTTVRTNASGLEVPLFHLFARLDEELHGTFPGLCVALMAVHGAIFLAGLVLNGLALYVFCCRTRAKTPSVIYTINLVVTDLLVGLSLPTRFAVYYGA---RGCLRCAFPHVLGYFLNMHCSILFLTCICVDRYLAIVRPEPAACRQPACARAVCAFVWLAAGAVTLSVLGVTG----------S-----------RPCCRVFALTVLEFLLPLLVISVFTGRIMCALSRP----GLLHQGRQRRVRAMQLLLTVLIIFLVCFTPFHARQVAVALWPDMHTSLVVYHVAVTLSSLNSCMDPIVYCFVTSGFQATVRGLFGQHGEREPSSGDVVSSGRHHILSAGPH >ACM1_HUMAN ------------MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLV-VL-AGQCYIQ------FLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRRGKAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPSRQC------- >ML1A_HUMAN -------MQGNGSALPNASQ---PVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGT-LQYDP-IYSCTFA------QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVQR-PDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNWKPSPLMTNNNV >TSHR_RAT LQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSPMALLGNVFVLFVLLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHTWQTG-PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSY----KVSICLPM-----TDTPLALAYIALVLLLNVVAFVIVCSCYVKIYITVRNP------QYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSGVLLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQANTGIQIQKIPQD >OPS2_DROME AQSS-GNGSVLDNVLPDMAHLVNPYWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSID--YMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHMNVRSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDG-LTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKEKCPMCVFGNTDEPKPDATSEADSKA---- >OPRD_HUMAN PPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPGA---VVCMLQ-FPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL-SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRARVTACTPSDGPG >OPSD_.ENLA MNGTEGPNFYVPMSNKTGVVRSPFDYPQYYLAEPWQYSALAAYMFLLILLGLPINFMTLFVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGPTGCYIEGFFATLGGEVALWSLVVLAVERYIVVCKPMANFRFGENHAIMGVAFTWIMALSCAAPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFTIPLIVIFFCYGRLLCTVKEAAAQQQESLTTQKAEKEVTRMVVIMVVFFLICWVPYAYVAFYIFTHQGSNFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQFRNCLITTLCCGKNPFGDEDGSSAASSVSSSQVSPA >PAFR_HUMAN ----------------------MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPITAQANTRKRGISLSLVIWVAIVGAASYFLILDSTN-G--NVTRCFEH---YEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQP---VQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDPFNQIPGNSLKN >OPSG_SCICA DSHEDSTQSSIFTYTNSNATRGPFEGPNYHIAPRWVYHITSTWMIIVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLAETVIASTISVVNQLYGYFVLGHPLCVVEGYTVSVCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIIPLSIIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATANPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDTSELSSASKSVSPAA------ >HH2R_RAT -------------------MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWN--RN-TF-KCKVQ--------VNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQR--ISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDD-INEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRRSQSREGRW--- >V1AR_RAT SSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITSSFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIETK--TQDCWAT---FIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNLLVVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSTSYSNNRSPTNS >GPR1_HUMAN EDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGLKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVSHRHRTLKNSLIVIIFIWLLASLIGGPALYFR--D--NN-HTLCYNNHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKV---------KKRTVLISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGNSETKNLCLLET >DADR_MACMU --------------MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAGN-TIDNCDSS--------LSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQVECESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGCIDSITFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLCPATNNAIETAAMFSSH----- >AG2R_CANFA ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYVAIVHPMSPVRRTMLMAKVTCIIIWLLAGLASLPTIIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKTLKRA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTRPSD-------H >OPSD_ATHBO MNGTEGPYFYIPMLNTTGVVRSPYEYPQYYLVNPAAYAVLGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNVEGFSATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMAAACAVPPLFGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFTCHFCIPLMVVFFCYGRLVCAVKEAAAAQQESETTQRAEREVTRMVIIMVVSFLVSWVPYASVAWYIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASSSSVSSSSVSPAA >RDC1_RAT YVEPGNYSDSNWPCNSSDCIVVDTVQCPAMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTTSSYKKKMVLRVVCVLVWLLAFFVSLPDTYYLKTVTNNE--TYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAM---------SASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHNVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDEYSALEQNAKA- >IL8A_RAT EGDFEEEFGNITRMLPTGEYFSPC----KR-VPMTNRQAVVVFYALVFLLSLLGNSLVMLVILYRRRTRSVTDVYVLNLAIADLLFSLTLPFLAVSKWKG--WIFGTPLCKMVSLLKEVNFFSGILLLACISVDRYLAIVHATRTLTRKRYLVKFVCMGTWGLSLVLSLPFAIFRQAYK-RS-GTVCYEV-LGEATADLRITLRGLSHIFGFLLPLFIMLVCYGLTLRTL---------FKAHMRQKRRAMWVIFAVVLVFLLCCLPYNLVLLSDTLLGAHNNIDQALYITEILGFSHSCLNPVIYAFVGQSFRHEFLKILAN--LVHKEVLTHHS------------ >CB2R_RAT ----MEGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHG-VDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPYKALVTRGRALVALGVMWVLSALISYLPLMGWTC-----CPSPCSEL------FPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHTEHQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKVTETEAEVKTTT >LSHR_HUMAN ESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCSTAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----KVSICFPM-----VETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNP------ELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRSNCKNGFTGSNK >OPSD_LIZSA MNGTEGPYFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAIERWMVVCKPISNFRFGEDHAIMGLAFTWVMAAACAVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFVCHFLIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVIMVVAFLICWCPYAGVAWYIFTHQGSEFGPLFMTFPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTSVSSSSVSPAA- >CB1R_FELCA EFYNKSLSSYKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKKIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCK-K--LQSVCSDI------FPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHIHSEDQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGHANNTANVHRAA >EDG3_HUMAN TALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAG-IAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCL-H--NLPDCSTI------LPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSS---KVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQCPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIRSKSSSSNNSSH >UR2R_HUMAN AATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKE-WHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMR---GP--KSLCLPA----WGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQR--ASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLRCSGRSLSSCSP >AA2B_CHICK --------------------------------MNTMKTTYIVLELIIAVLSIAGNVLVCWAVAINSTLKNATNYFLVSLAVADIAVGLLAIPFAITISIG--FQVDFHSCLFFACFVLVLTQSSIFSLLAVAIDRYLAIKIPLYNSLVTGKRARGLIAVLWLLSFVIGLTPLMGWNKAMG-A-FISCLFE-----NVVTMSYMVYFNFFGCVLLPLIIMLGIYIKIFMVACKQ---MGNSRTTLQKEVHAAKSLAIIVGLFAFCWLPLHILNCITHFHEEFSKPEWVMYVAIILSHANSVINPIIYAYRIRDFRYTFHKIISKILCKTDDFPKCTTVTNVNAPAASVT >5H2A_MOUSE NTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESNVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILAYKSSQLQVGQK >US27_HCMVA -------MTTSTNNQTLTQVSNMTNHTLNSTEIYQLFEYTRLGVWLMCIVGTFLNVLVITTILYYRRKKSPSDTYICNLAVADLLIVVGLPFFLEYAKHHP-KLSREVVCSGLNACFYICLFAGVCFLINLSMDRYCVIVWGVLNRVRNNKRATCWVVIFWILAVLMGMPHYLMYSHT-----NNECVGE-ANETSGWFPVFLNTKVNICGYLAPIALMAYTYNRMVRFI---------INYVGKWHMQTLHVLLVVVVSFASFWFPFNLALFLESIRLLANVIIFCLYVGQFLAYVRACLNPGIYILVGTQMRKDMWTTLRVFACCCVKQEIPYQKDIQRRAKHTKR >NK1R_HUMAN -----MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVICVIWVLALLLAFPQGYYST---SR---VVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLE---IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY----STRYLQTQGSVY >5H1A_HUMAN -MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAALISLTWLIGFLISIPPMLGW-----DP--DACTIS--------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRKNEEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ-------------------- >IL8B_MOUSE SGDLDIFN-YSSGMPSILPDAVPC----HSENLEINSYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNG--WTFGSTLCKIFSYVKEVTFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCIAMWLLSVILALPILILRNPVK-LS-TLVCYED-VGNNTSRLRVVLRILPQTFGFLVPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVLFTDTLMRTKDDIDKALNATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMATYGLVSKEFLAKEG------------ >GPRY_MOUSE LCSSHGMHFITNYSDQASQNFGVPNVTSCPMDEKLLSTVLTTFYSVIFLVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQRRAITTKQSIYVCCIVWTVALAGFLTMIILTLKK-----STMCFHY--RDRHNAKGEAIFNFVLVVMFWLIFLLIILSYIKIGKNLLRISKR--SKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNEIIHKTNEIMLVFSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQSEASRSESTSLHDLSVTVKMPQ >PAR2_RAT ---LDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIY--N--TTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTL------SAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLKSSS-------- >5H5A_MOUSE LPVNLTSFSLSTPSSLEPNRSDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGE-S-E-SEECQVS--------REPSYTVFSTVGAFYLPLWLVLFVYWKIYRAAKFRATVTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSW-DVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ----------------------- >IL8A_GORGO PQMWDFDDLNFTGMPPIDEDYSPC----RLETETLNKYVVIITYALAFLLSLLGNSLVMLVILYSRGGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMILSLPFFLFRQAYH-NS-SPVCYEV-LGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQNNVSLALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHR------------ >5H2A_RAT NTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESNVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILAYKSSQLQVGQK >SSR2_BOVIN ELNETQPWLTTPFDLNGSVGAANISNQTEPYYDLASNVVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDLNETTETQRTLL >GP42_HUMAN -----------------------MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD--T--GTCYLE-FWKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGR--------GGSHRRQRRVAGLVAATLLNFLVCFGPYNVSHVVGYICG---ESPVWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSGGEEQRADRPAE >APJ_MACMU ---------MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSRKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVNARLRLRVSGAVATAVLWVLAALLAMPVMVFRTTGDQCY-MDYSMVA-TVSSDWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFR--KERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLLFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSSSGHSQGPGPNM >AG22_MOUSE RNITSSRPFDNLNATGTNESAFNC----SHKPSDKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLALADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRT-LG--NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSREMD-------T >FSHR_SHEEP FDMMYSEFDYDLCSEVVDVTCSPEPDAFNPCEDIMGYDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVHVRHAASIMLVGWVFAFAVALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTRNFRRDFFILLSKFGCYEVQAQTYRSNFHPRNGHCPPA >YN84_CAEEL EVFHHISTTNKIFQKMFDKRNFSTDYTFNPKTFPGYRTYVASTYISFNVVGFVINAWVLYVVAPLLFVPKSILFYIFALCVGDLMTMIAMLLLVIELVFG--TWQFS-SMVCTSYLIFDSMNKFMAPMIVFLISRTCYSTVCLGEKAATLKYAIIQFCIAFAFVMILLWPVFAYSQVFTQEVVMRKCGFF----PPPQIEFWFNLIACITSYAVPLFGIIYWYVSVPFFLKRR---LVASSSMDAALRKVITTVLLLTVIYVLCWTPYWVSMFANRIWIMEKSIIIISYFIHLLPYISCVAYPLIFTLLNRGIRSAHAKIVADQRRRFRSLTDEASRTIPGTKMKKNE >5H1D_CANFA SPPNQSLEGLLQEASNRSLNATETPEAWGPETLQALKISLALLLSIITMATALSNAFVLTTIFLTRKLHTPANYLIGSLAMTDLLVSILVMPISIAYTTTRTWSFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGRAAVMIATVWVISICISIPPLFWR----Q-E--SDCQVN-------TSQISYTIYSTCGAFYIPSVLLIILYGRIYVAARNRKLALERKRISAARERKATKTLGIILGAFIVCWLPFFVASLVLPICRASWLHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQRVVHVRKAS--------------------- >GASR_BOVIN GASLCRSGGPLLNGSGTGNLSCEPPRIRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVVCKAVSYFMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVIVATWMLSGLLMVPYPVYTAVQP---V-LQCMHR---WPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGPGPTRPAQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGALSGAPISFIHLLTYASACVNPLVYCFMHRRFRQACLDTCTRCCPRPPRARPRPLPSIASLSRLSYT >BRS4_BOMOR QTLPSAISSIAHLESLNDSFILGAKQSEDVSPGLEILALISVTYAVIISVGILGNTILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDASRYIVDTWMFGRAGCKIISFIQLTSVGVSVFTLTVLSADRYRAIVKPLLQTSDAVLKTCGKAVCVWIISMLLAAPEAVFSDLYETT--FEACAPY---VSEKILQETHSLICFLVFYIVPLSIISAYYFLIAKTLYKSMPAHTHARKQIESRKRVAKTVLVLVALFAVCWLPNHMLYLYRSFTYHSAFHLSATIFARVLAFSNSCVNPFALYWLSRSFRQHFKKQVYCCKTEPPAS--QQSTGITAVKGNIQM >OPSB_RAT -----MSGE-EFYLFQNISSVGPWDGPQYHIAPVWAFHLQAAFMGFVFFAGTPLNATVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYLVICKPFGNIRFNSKHALTVVLITWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEHYTWFLFIFCFIIPLSLICFSYFQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLYLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMTD---ESDMSSTVSSSKVGPH- >NK2R_RABIT ----MGACDIVTEANISSDIDSNATGVTAFSMPGWQLALWATAYLALVLVAVVGNATVIWIILAHRRMRTVTNYFIVNLALADLCMATFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSGPGTKAVIAGIWLVALALAFPQCFYST---GA---TKCVVAWPEDSGGKMLLLYHLTVIALIYFLPLVVMFVAYSVIGFKLWRRPGHHGANLRHLRAKKKFVKTMVLVVVTFAVCWLPYHLYFLLGHFQDDIKFIQQVYLVLFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----HTPSLSVRVNRC >PAR2_MOUSE ---LETQPPITGKGVPVEPGFSIDEFSASILTGKLTTVFLPVVYIIVFVIGLPSNGMALWIFLFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNNWVYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHPRKKANIAVGVSLAIWLLIFLVTIPLYVMKQTIY--N--TTCHDVLPEEVLVGDMFNYFLSLAIGVFLFPALLTASAYVLMIKTL------SAMDEHSEKKRQRAIRLIITVLAMYFICFAPSNLLLVVHYFLIKTSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDHARNALLCRSVRTVNRMQISLKSGS-------- >OPSD_CARAU MNGTEGDMFYVPMSNATGIVRSPYDYPQYYLVAPWAYACLAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAISDLFMVFGGFTTTMYTSLHGYFVFGRVGCNPEGFFATLGGEMGLWSLVVLAFERWMVVCKPVSNFRFGENHAIMGVVFTWFMACTCAVPPLVGWSRYIPEGMQCSCGVDYYTRPQAYNNESFVIYMFIVHFIIPLIVIFFCYGRLVCTVKEAAAQHEESETTQRAEREVTRMVVIMVIGFLICWIPYASVAWYIFTHQGSEFGPVFMTLPAFFAKTAAVYNPCIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >TRFR_HUMAN ------------MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNLNVNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVKESDHFSTELDD >PE24_MOUSE GTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFID---WTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMAAAVASFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSRRTSSAMSGHSR >C3AR_CAVPO --------------MESSSAETNSTGLHLEPQYQPETILAMAILGLTFVLGLPGNGLVLWVAGLKMR-RTVNTVWFLHLTVADFVCCLSLPFSMAHLALRGYWPYGEILCKFIPTVIIFNMFASVFLLTAISLDRCLMVLKPICQNHRNVRTACIICGCIWLVAFVLCIPVFVYRETFT-EE-DDLSPFT-HEYRTPRLLKVITFTRLVVGFLLPMIIMVACYTLIIFRM--------RRVRVVKSWNKALHLAMVVVTIFLICWAPYHVFGVLILFINPEAALLSWDHVSIALASANSCFNPFLYALLGRDLRKRVRQSMKGILEAAFSEDISKSAFS--------- >GPR3_MOUSE GAGSSMAWFSAGSGSVNVSSVDPVEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAG-LGLVLHFAAD-F--CIGSPEMSLMLVGVLAMAFTASIGSLLAITVDRYLSLYNALYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCR-D--GLTTCGVV-------YPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHIALHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDA----DSPRLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSP------------ >OPSD_OCTDO --MVESTTLVNQTWWYNPTVDIHPHWAKFDPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDLSFSAINGFPLKTISAFMKWIFGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMASKKMSHRRAFLMIIFVWMWSIVWSVGPVFNWGAYVPEGILTSCSFD--YLSTDPSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHRLNLRKAQAGASAEMKLAKISMVIITQFMLSWSPYAIIALLAQFGPAEWVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWLLTCCQFDEKECEEVVASERG-GES >B1AR_MELGA WLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSLDVLCVTASIETLCVIAIDRYLAITSPFYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDL-K--GCCDFV--------TNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQNGRRKTSRVMAMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDL-VPDWLFVFFNWLGYANSAFNPIIYCRSP-DFRKAFKRLLCFPRKADRRLHAGGQFISTLGSPEHSP >5H1B_CAVPO PAVLGSQTGLPHANVSAPPNNAP-SHIYQDSIALPWKVLLVVLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAFTDLLVSILVMPISTMYTVTGRWTLGQALCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPRRAAGMIALVWVFSICISLPPFFWR----E-E--LDCLVN-------TDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGVILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTT--------------------- >BRB2_MOUSE IEMFNVTTQVLGSALNGTLSKDNC---PDTEWWSWLNAIQAPFLWVLFLLAALENLFVLSVFFLHKNSCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMRE-HN--TACVIV---YPSRSWEVFTNVLLNLVGFLLPLSVITFCTVRILQVLRNN---EMKKFKEVQTERKATVLVLAVLGLFVLCWVPFQISTFLDTLLRLGHAVDVITQISSYVAYSNSGLNPLVYVIVGKRFRKKSREVYRVLCQKGGCMGEPVQLRTS-------I >OPSB_APIME YVPSMREKFLGWNVPPEYSDLVRPHWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFSTSKSLRTPSNMFIVSLAIFDIIMAFEMPMLVISSFMERM--GWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYRTISCPI-DGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTEGFLTTCSFD--FLTDDEDTKVFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHNVKSNQDKER-SAEVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNRELLTPVSTMLPAVFAKTVSCIDPWIYAINHPRYRQELQKRCKWMGIHEPETTSDATKTDE-------- >O.YR_HUMAN GALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNRVAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANA-KEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGENSSSFVLSHRSS >OPSR_CAPHI ANFEESTQGSIFTYTNSNSTRDPFEGPNYHIAPRWVYHLTSAWMVFVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAIADLAETIIASTISVVNQMYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLATAGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMITCCFIPLSVIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVMVMIFAYCLCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDS-----SELASSV--SSVSPA >APJ_HUMAN ---------MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSRKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVNARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDQCY-MDYSMVA-TVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFR--KERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSSSGHSQGPGPNM >NY1R_PIG TLSSQVENHSIYYNFSEKNSQFLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEVMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPSNRHAYVGIAVIWVLAVASSLPFLIYQVLTDKD--KYVCFDK---FLSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMMRDNKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCINPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >OAR1_LYMST ---------MSRDIFMKRLRLHLLFDEVAMVTHIVGDVLSSVLLCAVVLLVLVGNTLVVAAVATSRKLRTVTNVFIVNLACADLLLGVLVLPFSAVNEIKDVWIFGHVWCQVWLAVDVWLCTASILNLCCISLDRYLAITRPIYPGLMSAKRAKTLVAGVWLFSFVICCPPLIGWNDGGT-Y--TTCELT--------NSRGYRIYAALGSFFIPMLVMVFFYLQIYRAAVKTHKPMRLHMQKFNREKKAAKTLAIIVGAFIMCWMPFFTIYLVGAFCENC-ISPIVFSVAFWLGYCNSAMNPCVYALFSRDFRFAFRKLLTCSCKAWSKNRSFRPIQLHCATQDDAK >OLF5_CHICK -------------MALGNCTTPTTFILSGLTDNPRLQMPLFMVFLAIYTITLLANLGLIALISVDFHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERRTISYVGCILQYFSFVLLTSSECLLLAVMAYDRYVAICKPLYPAIMTKAVCWRLVEGLYSLAFLNSLVHTSGLLKL---SNHFFCDNSQISSSSTTLNELLVFIFGSWFAMSSIITTPISYVFIILTV--------VRIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRVIATNVWIH-------------------- >A2AR_CARAU ----------MDVTQSNATKDDANITVTPWPYTETAAAFIILVVSVIILVSIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLANEIMGYWFFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVYNLKRTPKRIKSMIAVVWVISAVISFPPLIMTKH-------KECLIN--------DETWYILSSSLVSFFAPGFIMITVYCKIYRVAKQRSKQASKTKVAQMREKRFTFVLTVVMGVFVLCWFPFFFTYSLHAICGDSEPPEALFKLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKICLLDCAAHLRDSCLGTCIFECHQKSNQE >VQ3L_CAPVK SNYTTAYNTTYYSDDYDDYEVSIVDIPHCDDGVDTTSFGLITLYSTIFFLGLFGNIIVLTVLRKYKI-KTIQDMFLLNLTLSDLIFVLVFPFNLYDSIAKQ-WSLGDCLCKFKAMFYFVGFYNSMSFITLMSIDRYLAVVHPVSMPIRTKRYGIVLSMVVWIVSTIESFPIMLFYETKK-VY-ITYCHVF-YNDNAKIWKLFINFEINIFGMIIPLTILLYCYYKILNTL----------KTSQTKNKKAIKMVFLIVICSVLFLLPFSVTVFVSSLYLLNRFVNLAVHVAEIVSLCHCFINPLIYAFCSREFTKKLLRLRTTSSAGSISIG---------------- >GP40_HUMAN --------------------------------MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGTPVGSPVCLEA----WDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRAL-------ARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYP--NLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK------------------ >CKR8_MACMU --MDYTLDPSMTTMTDYYYPDSLSSPCDGELIQRNDKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRNITDIYLLNLALSDLLFVFSFPFQTYYQLDQ--WVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVIKVRTIRMGTTTLSLLVWLTAIMATIPLLVFYQVAS-ED-VLQCYSF-YNQQTLKWKIFTNFEMNILGLLIPFTIFMFCYIKILHQL---------KRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHQQLNYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSHIFIYLGRQMSSSCQQHSFRSS >NTR1_RAT EATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQN--SGGLVCTPI---VDTATVKVVIQVN-TFMSFLFPMLVISILNTVIANKLTVMEHSMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPSMSSNHAFSTSA >B3AR_MACMU MAPWPHGNSSLVPWPDVPTLAPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIVAITRTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLVLTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRVQ-R--RCCAFA--------SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPS-VPDPAFLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCHCGGRLPREPCAADAPLRPGPAPRSP >GALS_MOUSE ------------MNGSDSQGAEDSSQE-GGGGWQPEAVLVPLFFALIFLVGAVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPMSRELRTPRNALAAIGLIWGLALLFSGPYLSYYS---AN--LTVCHPA----WSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLHYLWRTDP-VAAGSGSQRAKRKVTRMIVIVAVLFCLCWMPHHALILCVWFGRFPRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRRAPRRASGRVHSGGMLEPESTD >P2Y3_MELGA ----------------MSMANFTAGRNSCTFQEEFKQVLLPLVYSVVFLLGLPLNAVVIGQIWLARKALTRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCKFVRFQFYTNLHGSILFLTCISVQRYMGICHPLWHKKKGKKLTWLVCAAVWFIVIAQCLPTFVFASTG-----RTVCYDL-SPPDRSASYFPYGITLTITGFLLPFAAILACYCSMARILCQK---ELIGLAVHKKKDKAVRMIIIVVIVFSISFFPFHLTKTIYLIVRSSQAFAIAYKCTRPFASMNSVLDPILFYFTQRKFRESTRYLLDKMSSKWRHDHCITY------------ >OPSD_TURTR MNGTEGLNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSVLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVANLFMVFGGFTTTLYTSLHAYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWIMAMACAAAPLVGWSRYIPEGMQCSCGIDYYTSRQEVNNESFVIYMFVVHFTIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFTHQGSDFGPIFMTIPSFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGRNPLGDDEASTTASKTETSQVAPA >A2AB_CAVPO -------------------------MDHQEPYSVQATAAIAAVITFLILFTIFGNALVILAVLTSRSLPAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCKIN--------QEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSGAVWWRRRTQMTREKRFTFVLAVVIGVFVLCWFPFFFTYSLGAICPQHKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTAW------------------ >CML1_MOUSE EYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVIYSLVCFLGLLGNGLVIVIATFKMK-KTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYHWVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVSQNHRSIRLAYMTCSAVWVLAFFLSSPSLVFRDTAN-SS--HPAHSQ-VVSTGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKL---------QRNRLAKNKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRK-FKVALFSRLANALSEDTGPSFTKMSSLNEKAS >5HT1_APLCA -MKSLKSSTHDVPHPEHVVWAPPAYDEQHHLFFSHGTVLIGIVGSLIITVAVVGNVLVCLAIFTEPISHSKSNFFIVSLAVADLLLALLVMTFALVNDMYGYWLFGETFCFIWMSADVMCETASIFSICVISYDRLKQVQKPLYEEFMTTTRALLIIACLWICSFVLSFVPIFLEWHELGD-AKHVCLFD--------VHFTYSVIYSFICFYVPCTLMLTNYLRLFLIAQTHQLRASSYRNQGTQGSKAARTLTIITGTFLACWLPFFIINPIAAADEHL-IPLECFMVTIWLGYFNSSVNPIIYGTSNSKFRAAFKRLLRCRSVKSVVGSISPVSWIRPSRLDLSS >5H1A_FUGRU NDSNATSGYSDTAAVDWDEGENATGSGSLPDPELSYQIITSLFLGALILCSIFGNSCVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQDICDLFIALDVLCCTSSILHLCAIALDRYWAITDPIYVNKRTPRRAAVLISVTWLIGFSISIPPMLGWRS---NP--DACIIS--------QDPGYTIYSTFGAFYIPLILMLVLYGRIFKAARFRINEGTRRKIALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCAENYMPEWLGAVINWLGYSNSLLNPIIYAYFNKDFQSAFKKILRCKFHRH-------------------- >ACTR_BOVIN -------------MKHILNLYENINSTARNNSDCPAVILPEEIFFTVSIVGVLENLMVLLAVAKNKSLQSPMYFFICSLAISDMLGSLYKILENVLIMFKNMGSFESTADDVVDSLFILSLLGSICSLSVIAADRYITIFHALYHRIMTPHRALVILTVLWAGCTGSGITIVTFFS----------------------HHHVPTVIAFTALFPLMLAFILCLYVHMFLLARSH---TRRTPSLPKANMRGAVTLTVLLGVFIFCWAPFVLHVLLMTFCPADACYMSLFQVNGVLIMCNAIIDPFIYAFRSPELRVAFKKMVICNCYQ--------------------- >CKR9_MOUSE DDFSYDSTASTDDYMNLNFSSFFC---KKNNVRQFASHFLPPLYWLVFIVGTLGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLATLPFWAIAAAGQ--WMFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIVQAMVWRQKRLLYSKMVCITIWVMAAVLCTPEILYSQVSG-G--IATCTMVYPKDKNAKLKSAVLILKVTLGFFLPFMVMAFCYTIIIHTL---------VQAKKSSKHKALKVTITVLTVFIMSQFPYNSILVVQAVDAYATNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFT--------GSLK >5H1B_SPAEH CAPPPPAGSQTQTPSSNLSHNSADSYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPRRAAVMIALVWVFSISISLPRFFWR----E-E--LDCLVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDAWFHMAIFDFFNWLGYLNSLINPIIYTMPNEDFKQAFHKLIRFKCTG--------------------- >OPS4_DROVI VSGNGDLQFLGWNVPPDQIQHIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKALRTPSNMFVLNLAVFDFIMCLKAPIFIYNSFHRG-FALGNTGCQIFAAIGSYSGIGAGMTNAAIGYDRLNVITKPM-NRNMTFTKAIIMNVIIWLYCTPWVVLPLTQFWDRFPEGYLTSCTFD--YLTDNFDTRLFVGTIFFFSFVCPTLMIIYYYSQIVGHVFSHNVESNVDKSKDTAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRMELQKRCPWLAIDEKAPESSSAEQQQTTAA---- >OPSG_RABIT ESHEDSTQASIFTYTNSNSTRGPFEGPNFHIAPRWVYHLTSAWMILVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETVIASTISVVNQFYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIAGIAFSWIWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIIPLSVIVLCYLQVWMAIRTVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYSFHPLVAAIPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVEDS-----SELASSV--SSVSPA >NK3R_RABIT LVQAGNLSSSLPSSVPGLPTTPRANLTNQFVQPSWRIALWSLAYGVVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL-KPRLSATATKIVIGSIWILAFLLALPQCLYSK---GR---TLCYVQ--WPEGPKQHFIYHIIVIILVYCFPLLIMGITYTIVGITLWGG--PCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELEPTRQSSLYTVTR >ACM5_HUMAN -------MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLV-VP-LDECQIQ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRNPSTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYW------------ >O3A1_HUMAN ----------MQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVRGNLSILAAVLVEPKLHTPMYFFLGNLSVLDVGCISVTVPSMLSRLLSRKRAVPCGACLTQLFFFHLFVGVDCFLLTAMAYDQFLAICRPLYSTRMSQTVQRMLVAASWACAFTNALTHTVAMSTL---NNHFYCDLPQLSCSSTQLNELLLFAVGFIMAGTPMALIVISYIHVAAAV--------LRIRSVEGRKKAFSTCGSHLTVVAIFYGSGIFNYMRLGSTK---LSDKDKAVGIFNTVINPMLNPIIYSFRNPDVQSAIWRMLTGRRSLA-------------------- >CKRB_BOVIN YNQSTDYYYEENEMNDTHDYSQYEVICIKEEVRKFAKVFLPAFFTIAFIIGLAGNSTVVAIYAYYKKRRTKTDVYILNLAVADLFLLFTLPFWAVNAVHG--WVLGKIMCKVTSALYTVNFVSGMQFLACISTDRYWAVTKAP-SQSGVGKPCWVICFCVWVAAILLSIPQLVFYTVN----HKARCVPI--YHLGTSMKASIQILEICIGFIIPFLIMAVCYFITAKTL---------IKMPNIKKSQPLKVLFTVVIVFIVTQLPYNIVKFCQAIDIIYKRMDVAIQITESIALFHSCLNPVLYVFMGTSFKNYIMKVAKKYGSW---------NVEEIPFESEDA >TA2R_HUMAN --MWPNG-----------SSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLT----LGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRRVSLCGPAWSTATSASRVQAIL >AG2R_CHICK ------MVPNYSTEETVKRIHVDC---PVSGRHSYIYIMVPTVYSIIFIIGIFGNSLVVIVIYCYMKLKTVASIFLLNLALADLCFLITLPLWAAYTAMEYQWPFGNCLCKLASAGISFNLYASVFLLTCLSIDRYLAIVHPVSRIRRTMFVARVTCIVIWLLAGVASLPVIIHRNIFF-LN--TVCGFR-YDNNNTTLRVGLGLSKNLLGFLIPFLIILTSYTLIWKTLKKA----YQIQRNKTRNDDIFKMIVAIVFFFFFSWIPHQVFTFLDVLIQLHDIVDTAMPFTICIAYFNNCLNPFFYVFFGKNFKKYFLQLIKYIPPNVSTHPSLTTRPPE-------N >P2YR_MOUSE AAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTG----KTVTCYDT-TSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVKALIY------NDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLSEFKQNGDTSL >NY5R_RAT -------------NTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVESS--KYLCVES---WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGAHEKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS--------------------- >THRR_PAPHA LTEYRLVSINKSSPLQKPLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPVNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYLSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQ--N--TTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCL------SSSTVANRSKKSRALFLSAAVFCIFIICFGPTNILLIAHYSFLSHEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSSNSSGDTCS-------- >FSHR_HUMAN FDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNP------NIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTNTHPRNGHCSSA >OPSB_CONCO MNGTEGPNFYVPMSNATGVVRSPFEYPQYYLAEPWAFSILAAYMFFLIITGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGETGCNLEGYFATLGGEISLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLTLTWVMANACAMPPLFGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFLVHFTIPLTIISFCYGRLVCAVKEAAAQQQESETTQRAEREVTRMVVIMVISFLVCWIPYASVAWYIFTHQGSTFGPIFMTVPSFFAKSSSIYNPMIYICMNKQFRNCMITTLFCGKNPFEGEE--EGASAVSS--VSPA >A2AA_HUMAN ----MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGQ-P--PRCEIN--------DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRRVGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >OPSD_TRIMA MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTLPAFFAKSASIYNPVIYIMMNKQFRNCMLTTICCGKNPFAEEEGATTVSKTETSQVAPA >AA3R_HUMAN -------------------------MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLG--ITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWN-MKE-Y-FLSCQFV-----SVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNK--NSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTS------------ >ET1R_HUMAN ELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPKT--HKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRGSL-IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNESFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPWKNHDQNNHNTD >GALS_HUMAN ------------MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR---AN--LTVCHPA----WSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRADP-VAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVHSGSVLERESSD >OPSV_ORYLA -------MGKYFYLYENISKVGPYDGPQYYLAPTWAFYLQAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVAGLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGV-VRCPPFFGWSRYIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRAVAAQQAESASTQKAEKEVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQFNGCIMEMVFGKKMEE-----ASESTDS-------- >YWO1_CAEEL ----------------------------MNHVDYVAHVIVMPIVLSIGMINQCLNVCTLLHIRT------SIFLYLKASAIADILSIVAFIPFLFRHAKLIDELGMFYHAHLELPLINALISASALNIVAMTVDRYVSVCHPINETKPSRRRTMLIIVMIYFIALMIYFPSVFQKKLG-VTTIYTIVRNE---VEALQVFKFYLIVRECICRWGPVLLLVILNMCVVRGLRKIRTEQRQLRSPRDDRSRISVLLFVTSATFIICNIPASVISFFVRRVSGSLFWQIFRAIANLLQVTSYLYNFYLYALCSSEYRHAFLRLFGCRSSLSPTSTGDSPGKRCHQAVVLLG >CKR5_RAT --MDFQGSIPTYIYDIDYSMSAPC---QKVNVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANE--WVFGNIMCKLFTGIYHIGYFGGIFFIILLTIDRYLAIVHAVAIKARTVNFGVITSVVTWVVAVFVSLPEIIFMRSQK-EG-HYTCSPHFLHIQYRFWKHFQTLKMVILSLILPLLVMVICYSGILNTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEYFNRLDQAMQVTETLGMTHCCLNPVIYAFVGEKFRNYLSVFFRKHIVKRFCKHCSIFV-------SSVY >5HT_HELVI TSSEWFDGSNCSWVDAVSWGCTSTNATSTDVTSFVLMAVTSVVLALIILATIVGNVFVIAAIIIERNLQNVANYLVASLAVADLMVACLVMPLGAVYEVSQGWILGPELCDMWTSSDVLCSSASILHLVAIATDRYWAVTDV-YIHIRNEKRIFTMIVLVWGAALVVSLAPQLGWKDPDT-Q--QKCLVS--------QDLAYQIFATMSTFYVPLAVILILYWKIFQTARRRPAPEKKESLEAKRERKAAKTLAIITGAFVFCWLPFFIMALVMPICQTCVISDYLASFFLWLGYFNSTLNPVIYTIFSPDFRQAFARILFGTHRRRRYKKF--------------- >NTR2_HUMAN -----METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARARAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKH--AASRVCTVL---VVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALGQVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPMDTASGFGDPPE >NY4R_MOUSE HFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFIITTYSIETILGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPT-GWKPSIFQAYLGIVVIWFISCFLSLPFLANSTLNDED--KVVCFVS---WSSDHHRLIYTTFLLLFQYCIPLAFILVCYIRIYQRLQRQKHVAHACSSRAGQMKRINSMLMTMVTAFAVLWLPLHVFNTLEDWYQEACHGNLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIKALVLTCHCRSPQGES---TVHTDLSKGSMR >PE21_RAT --MSPYG-LNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAG-RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFIS--LGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRDRRRSRGLRRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLSSLRSSRHSGFS >OPSG_RAT DHYEDSTQASIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSTWMILVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDS-----SELVSSV--SSVSPA >P2UR_MOUSE ----MAADLEPWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLSLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTS-----RITCHDT-SARELFSHFVAYSSVMLGLLFAVPFSVILVCYVLMARRLLKP---YGTTGGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARRKL--TVRKDLSVSS >A2AC_DIDMA -MDLQLTTNSTDSGDRGGSSNESLQRQPPSQYSPAEVAGLAAVVSFLIVFTIVGNVLVVIPVLTSRALKAPQNLFLVSLASADILVATLVMPFSLANELMNYWYFGKVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVYNLKRTPRRIKGIIVTVWLISAVISFPPLISLYR-------PQCELN--------DETWYILSSCIGSFFAPCIIMVLVYVRIYRVAKLRRRKLCRRKVTQAREKRFTFVLAVVMGVFVVCWFPFFFTYSLYGICREAQVPETLFKFFFWFGYCNSSLNPVIYTIFNQDFRRSFKHILFKKKKKTSLQ----------------- >GPR1_RAT EVSREMLFEELDNYSYALEYYSQEPDAEENVYPGIVHWISLLLYALAFVLGIPGNAIVIWFMGFKWK-KTVTTLWFLNLAIADFIFVLFLPLYISYVALSFHWPFGRWLCKLNSFIAQLNMFSSVFFLTVISLDRYIHLIHPGSHPHRTLKNSLLVVLFVWLLASLLGGPTLYFR--D--NN-RIICYNNQEYELTLMRHHVLTWVKFLFGYLLPLLTMSSCYLCLIFKT---------KKQNILISSKHLWMILSVVIAFMVCWTPFHLFSIWELSIHHNNVLQGGIPLSTGLAFLNSCLNPILYVIISKKFQARFRASVAEVLKRSLWEASCSGSAETKSLSLLET >CCR4_PAPAN IYTSDNYTEEMG-SGDYDSIKEPC---FREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFASVSE-DD-RYICDRF---YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKG----------GH >D2D1_.ENLA ---MDPQNLSMYNDD------INNGTNGTAVDQKPHYNYYAMLLTLLVFVIVFGNVLVCIAVSREKALQTTTNYLIVSLAVADLLVATLVMPWAVYMEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLN---S----KVCII---------DNPAFVIYSSIVSFYVPFIVTLLVYVQIYIVLRKRRTSMSKKKLSQHKEKKATQMLAIVLGVFIICWLPFFIIHILNMHCNCN-IPQALYSAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKILHC------------------------- >OLF8_RAT ---------------MNNKTVITHFLLLGLPIPPEHQQLFFALFLIMYLTTFLGNLLIVVLVQLDSHLHTPMYLFLSNLSFSDLCFSSVTMLKLLQNIQSQVPSISYAGCLTQIFFFLLFGYLGNFLLVAMAYDRYVAICFPLYTNIMSHKLCTCLLLVFWIMTSSHAMMHTLLAARL---SLNFFCDLFKLACSDTYVNELMIHIMGVIIIVIPFVLIVISYAKIISSI--------LKVPSTQSIHKVFSTCGSHLSVVSLFYGTIIGLYLCPSGDN---FSLKGSAMAMMYTVVTPMLNPFIYSLRNRDMKQALIRVTCSKKISLPW------------------ >GASR_MOUSE GSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQP---I-LQCMHL---WPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGTGPPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPSIASLSRLSYT >OPRK_CAVPO LPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVDVD-IIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLL-SGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVAYMRNVDGVNKP >OLFD_CANFA -------------MTEKNQTVVSEFVLLGLPIDPDQRDLFYALFLAMYVTTILGNLLIIVLIQLDSHLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSIPYAGCLTQMYFFLFFGDLESFLLVAMAYDRYVAICFPLYTTIMSPKLCFSLLVLSWVLTMFHAVLHTLLMARL---CPHFFCDMSKLACSDTQVNELVIFIMGGLILVIPFLLIITSYARIVSSI--------LKVPSAIGICKVFSTCGSHLSVVSLFYGTVIGLYLCPSANN---STVKETIMAMMYTVVTPMLNPFIYSLRNKDMKGALRRVICRKKITFSV------------------ >O2F1_HUMAN -------------MGTDNQTWVSEFILLGLSSDWDTRVSLFVLFLVMYVVTVLGNCLIVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAYDRYVAVCDALYSAIMHGGLCARLAITSWVSGFISSPVQTAITFQL---PDHISCELLRLACVDTSSNEVTIMVSSIVLLMTPFCLVLLSYIQIISTI--------LKIQSREGRKKAFHTCASHLTVVALCYGVAIFTYIQPHSSP---SVLQEKLFSVFYAILTPMLNPMIYSLRNKEVKGAWQKLLWKFSGLTSKLAT--------------- >OPS._MOUSE ------------MLSEASDFNSSGSRSEGSVFSRTEHSVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYA--PTGATCTIN--WRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAS-TAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKCQPHLAVPEPSTLPLAPVRI------ >A1AB_RAT HNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRTYRPWTRGGSLE >D4DR_RAT ---MGNSSATGDGGLLAGRGP---ESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPL-RYNQQGQCQLLLIAATWLLSAAVAAPVVCGLN---G-R--TVCCL---------EDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWPAPRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC----------------------- >GP52_HUMAN SRWTEWRILNMSSGIVNASERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFAFHCAPLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCRVFGYIISVLKSVSMACLACISVDRYLAITKPLYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWG---PGY-IFEWCAT-----SWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHFPSDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRV--LDNPTLSFLTTWLAVSNSFCNCVIYSLSNGVFRLGLRRLFETMCTSCMCVKDQEARANSCSI----- >ACTR_MOUSE -------------MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGSFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALYHSIVTMRRTIITLTIIWMFCTGSGITMVIFFS----------------------HHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSH---ARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY---------------------- >SSR4_HUMAN GEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRH-WPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPGGQ-AVACNLQ---WPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR-AGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLVVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLEGAGGAEETALKSKGGAGCM >OPSD_PIG MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFMLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGLALTWVMALACAAPPLVGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFSIPLVIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWLPYASVAFYIFTHQGSDFGPIFMTIPAFFAKSASIYNPVIYIMMNKQFRNCMLTTLCCGKNPLGDDEASTTTSKTETSQVAPA >GRHR_SHEEP --MANGDSPDQNENHCSAINSSILLTPGSLPTLTLSGKIRVTVTFFLFLLSTIFNTSFLLKLQNWTQKLSKMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPL-AVKSNSKLGQFMIGLAWLLSSIFAGPQLYIFGMIHEG--FSQCVTH--SFPQWWHQAFYNFFTFSCLFIIPLLIMLICNAKIIFTLTRVPHKNQSKNNIPQARLRTLKMTVAFATSFTVCWTPYYVLGIWYWFDPDMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >DOP1_DROME YDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTDGSPRIG-NLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPLI-KYPTCALD--------LTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHFKVHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNP---------------------- >AA1R_RABIT ----------------------------MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIG--PETYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLYKAVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLRN-G-VIKCEFE-----KVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRRQK-ASGDPHKYYGKELKIAKSLALILFLFALSWLPLHILNCVTLFCPSCQKPSILVYTAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCRPAPAGDGDPND--------- >OPSI_ASTFA LNGFEGDNFYIPMSNRTGLVRDPFVYEQYYLAEPWQFKLLACYMFFLICLGLPINGFTLFVTAQHKKLQQPLNFILVNLAVAGMIMVCFGFTITISSAVNGYFYFGPTACAIEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSASHALGGIGFTWFMAMTCAAPPLVGWSRYIPEGLQCSCGPDYYTLNPKYNNESYVIYMFVVHFIVPVTVIFFTYGRLVCTVKSAAAAQQDSASTQKAEKEVTRMVILMVVGFLVAWTPYATVAAWIFFNKGAAFTAQFMAVPAFFSKSSALFNPIIYVLLNKQFRNCMLTTLFCGKNPLGDEESSTVTVSS----VSPA >ACTR_HUMAN -------------MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFFS----------------------HHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSH---TRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW--------------------- >CCR4_RAT IYTSDNYSEEVG-SGDYDSNKEPC---FRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMAD--WYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATSQSARKLLAEKAVYVGVWIPALLLTIPDIIFADVSQ-DG-RYICDRL---YPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLESVVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKG----------GH >OPSD_ANOCA MNGTEGQNFYVPMSNKTGVVRNPFEYPQYYLADPWQFSALAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLGGEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSRYIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKAAAAQQQESATTQKAEREVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQFRNCMIMTLCCGKNPLGDEETSAGTSTVSTSQVSPA >ML1A_CHICK -------MRANGSELNGTVLPRDPPAEGSPRRPPWVTSTLATILIFTIVVDLLGNLLVILSVYRNKKLRNAGNIFVVSLAIADLVVAIYPYPLVLTSVFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLYDKLYSDKNSLCYVGLIWVLTVVAIVPNLFVGS-LQYDP-IYSCTFA------QSVSSAYTIAVVFFHFILPIAIVTYCYLRIWILVIQVRR-PDNNPRLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETRIPEWLFVSSYYMAYFNSCLNAIIYGLLNQNFRREYKKIVVSFCTAKAFFQDSSNSKPSPLITNNNQ >EDG1_HUMAN VKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCI-S--ALSSCSTV------LPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRLTFISKASRSSE-NVALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKEFSRSKSDNSSH >OPS1_DROPS APS---NGSVVDKVTPDMAHLISPYWDQFPAMDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSTIWCCLAPVFWSRYVPEGNLTSCGID--YLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHMNVRSSEDADKSAEGKLAKVALVTISLWFMAWTPYLVINCMGLFKFEG-LTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGK-SSTSEAESKA---- >PAFR_CAVPO ----------------------MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPITAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTN-G--NITRCFEH---YEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQP---VKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDPINHTPVNPIKN >OPSB_MOUSE -----MSGEDDFYLFQNISSVGPWDGPQYHLAPVWAFRLQAAFMGFVFFVGTPLNAIVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYVVICKPFGSIRFNSKHALMVVLATWIIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIIPLSLICFSYSQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMAD---ESDVSSTVSSSKVGPH- >HH2R_CANFA -------------------MISNGTGSSFCLDSPPCRITVSVVLTVLILITIAGNVVVCLAVGLNRRLRSLTNCFIVSLAITDLLLGLLVLPFSAFYQLSCRWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLYPVLITPVRVAVSLVLIWVISITLSFLSIHLGWN--RN-TIPKCKVQ--------VNLVYGLVDGLVTFYLPLLVMCITYYRIFKIARDQR--MGSWKAATIGEHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDD-INEAFEAVVLWLGYANSALNPILYATLNRDFRTAYQQLFRCRPASHNAQETSLRRNQSREPMR--- >C3.1_MOUSE --MSTSFPELDLENFEYDDSAEAC---YLGDIVAFGTIFLSVFYALVFTFGLVGNLLVVLALTNSRKPKSITDIYLLNLALSDLLFVATLPFWTHYLISHEG--LHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAASMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKD-----NECLGDYPEVLQEMWPVLRNSEVNILGFALPLLIMSFCYFRIIQTL---------FSCKNRKKARAVRLILLVVFAFFLFWTPYNIMIFLETLKFYNRDLRLALSVTETVAFSHCCLNPFIYAFAGEKFRRYLGHLYRKCLAVLCGHPVHTGRSRQDSILSS-F >ML1._SHEEP ---------MGRTLAVPTPYGCIGCKLPQPDYPPALIVFMFCAMVITIVVDLIGNSMVILAVSKNKKLRNSGNVFVVSLSVADMLVAIYPYPLMLHAMAIGGWDLSKLQCQMVGFITGLSVVGSIFNIMAIAINRYCYICHSLYERIFSVRNTCIYLAVTWIMTVLAVLPNMYIGT-IEYDP-TYTCIFN------YVNNPAFAVTIVCIHFVLPLLIVGFCYVKIWTKVLAARD-AGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINALTVLVAVNPKEKIPNWVYLAAYFIAYFNSCLNAVIYGVLNENFRREYWTIFHAMRHPVLFLSGLLTAQAHTHARARAR >GRPR_MOUSE NCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPQT--FISCAPY---HSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSLPVNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNR--SHSMTSFKSTNP-SA >OPS._HUMAN ------------MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYA--PTGATCTIN--WRKNDRSFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHSD-TESLNRDWSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPLASGRI------ >5HT1_DROME VSYQGITSSNLGDSNTTLVPLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGN--E-G--PICTVC--------QNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRILLGHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETM-HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYPPSQRVMLGDER >CRH2_MOUSE ------MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMR-QTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPWNPRDTTCDY---------RQKALAVSKFLLAFMVPLAIIASSHVAVSLRL---------HHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHS-QLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSRRASSTATPAST >ML1C_CHICK -------------MERPGSNGSCSGCRLEGGPAARAASGLAAVLIVTIVVDVLGNALVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILSAIFHNGWTMGNIHCQISGFLMGLSVIGSIFNITAIAINRYCYICHSLYDKLFNLKNTCCYICLTWTLTVVAIVPNFFVGS-LQYDP-IYSCTFA------QTVSTSYTITVVVVHFIVPLSIVTFCYLRIWILVIQVHR-QDCKQKIRAADIRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPSKHIPEWLFVLSYFMAYFNSCLNAVIYGLLNQNFRKEYKRILLMLRTPRLLFIDVSKSKPSPAVTNNNQ >5H1F_HUMAN -------------MDFLNSSD-QNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVYARKRTPKHAGIMITIVWIISVFISMPPLFWR----S-R--DECIIK-------HDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLFKHWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC----------------------- >GRHR_PIG --MANSASPEQNQNHCSAINSSILLTQGNLPTLTLSPNIRVTVTFFLFLLSTAFNASFLLKLQKWTQKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPL-AVKSNSRLGRFMIGLAWLLSSIFAGPQLYIFRMIHEG--FSQCVTH--SFPQWWHQAFYDFFTFSCLFIIPLLIMLICNAKIMFTLTRVPHNNQSKNNIPRARLRTLKMTVAFAASFIVCWTPYLVLGIWYWFDPEMRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL------------------------------------- >MAS_MOUSE ------MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMR-RNPFTVYITHLSMADISLLFCIFILSIDYALDYESSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIYTSHRPKHQSAFVCALLCALSCLVTTMEYVMCI-DSHS--RSDC-----------RAVIIFIAILSFLVFTPLMLVSSSILVVKIRK----------NTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYW--SAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRTVSIETVV---- >UL33_HCMVA ----------------------------MTGPLFAIRTTEAVLNTFIIFVGGPLNAIVLITQLLTNRGYSTPTIYMTNLYSTNFLTLTVLPFIVLSNQ-WL-LPAGVASCKFLSVIYYSSCTVGFATVALIAADRYR-VLHKRTYARQSYRSTYMILLLTWLAGLIFSVPAAVYTTVVMN-NGHATCVLYVAEEVH-TVLLSWKVLLTMVWGAAPVIMMTWFYAFFYSTV---------QRTSQKQRSRTLTFVSVLLISFVALQTPYVSLMIFNSYATTATLRRTIGTLARVVPHLHCLINPILYALLGHDFLQRMRQCFRGQLLDRRAFLRSQQTNLAAGNNSQSV >CKR5_GORGO ----MDYQVSSPTYDIDYYTSEPC---QKTNVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >PE21_MOUSE --MSPCG-LNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAG-RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFIS--LGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRDRRRSRGPRRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLSSLRSSRHSGFS >A1AB_MESAU HNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--AP--KECGVT--------EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTHNPIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRTYRPWTRGGSLE >O3A2_HUMAN ----------MEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGGNLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRLLAICQPLYSTRMSQTVQRMLVAASLACAFTNALTHTVAMSTL---NNHFYCDLPQLSCSSTQLNELLLFAVGFIMAGTPLVLIITAYSHVAAAV--------LRIRSVEGRKKAFSTCGSHLTVVCLFFGRGIFNYMRLGSEE---ASDKDKGVGVFNTVINPMLNPLIYSLRNPDVQGALWQIFLGRRSLTA------------------- >OPSU_CARAU -------MDAWTYQFGNLSKISPFEGPQYHLAPKWAFYLQAAFMGFVFFVGTPLNAIVLFVTMKYKKLRQPLNYILVNISLGGFIFDTFSVSQVFFSALRGYYFFGYTLCAMEAAMGSIAGLVTGWSLAVLAFERYVVICKPFGSFKFGQSQALGAVALTWIIGIGCATPPFWGWSRYIPEGIGTACGPDWYTKNEEYNTESYTYFLLVSCFMMPIMIITFSYSQLLGALRAVAAQQAESASTQKAEKEVSRMVVVMVGSFVVCYGPYAITALYFSYAEDSNKDYRLVAIPSLFSKSSCVYNPLIYAFMNKQFNACIMETVFGKKIDE-----SSESSVSA------- >PAFR_RAT ----------------------MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPITAQATTRKRGITLSLVIWISIAATASYFLATDSTN-G--NITRCFEH---YEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRP---VRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDPANQTPVLPLKN >YYO1_CAEEL ISPNASNYLTYPFDGLCLQKFFYQLQTSLRRFTPYEEIIYTTVYIIISVAAVIGNGLVIMAVVRKKTMRTNRNVLILNLALSNLILAITNIPFLWLPSIDFEFPYSRFFCKFANVLPGSNIYCSTLTISVMAIDRYYSVKKLKASNRKQCFHAVLVSLAIWIVSFILSLPLLLYYETS--MQEVRQCRLVRLPDITQSIQLLMSILQVAFLYIVPLFVLSIFNVKLTRFLKTNDSHLKNNNKTNQRTNRTTSLLIAMAGSYAALWFPFTLITFLIDFELIINLVERIDQTCKMVSMLSICVNPFLYGFLNTNFRHEFSDIYYRYIRCETKSQPAGRIAHHRQDSVYND >OPS1_LIMPO PN-----ASVVDTMPKEMLYMIHEHWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFMMPTMTSNCFAETWILGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAAPLTHKKATLLLLFVWIWSGGWTILPFFGWSRYVPEGNLTSCTVD--YLTKDWSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHNVAANADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIISWAGVFSSGTRLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLACGSGESGSDVKTMEEKPKIPEA- >OPSV_APIME YLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPNPSLHYLLALLYILFTFLALLGNGLVIWIFCAAKSLRTPSNMFVVNLAICDFFMMIKTPIFIYNSFNTG-FALGNLGCQIFAVIGSLTGIGAAITNAAIAYDRYSTIARPL-DGKLSRGQVILFIVLIWTYTIPWALMPVMGVWGRFPEGFLTSCSFD--YLTDTNEIRIFVATIFTFSYCIPMILIIYYYSQIVSHVVNHNVDSNANTSSQSAEIRIAKAAITICFLYVLSWTPYGVMSMIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAISHPKYRLELQKRLPWLELQEKPISDSTSTPPASS------ >5H1B_DIDMA PPASGSLTSSQTNHSTFPNPNAPDLEPYQDSIALPWKVLLATFLGLITLGTTLSNAFVIATVSRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVYSAKRTPKRAAGMIIMVWVFSVSISMPPLFWR------E--ADCSVN-------TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRKVSLEKKKLMAARERKATRTLGIILGAFIVCWLPFFIISLALPICDDAWFHLAIFDFFNWLGYLNSLINPIIYTKSNDDFKQAFQKLMRFRRTS--------------------- >NY2R_PIG EEMKMEPSGPGHTTPRGELAPDSEPELKDSTKLIEVQIILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKRISFLIIGLAWGISALLASPLAIFREYS-FE--IVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYARIWSKLKNHSPG-GVNDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKNLEATKNGG >B1AR_.ENLA WGPMEC--RNRS----GTPTTVPSPMHPLPELTHQWTMGMTMFMAAIILLIVMGNIMVIVAIGRNQRLQTLTNVFITSLACADLIMGLFVVPLGATLVVSGRWLYGSIFCEFWTSVDVLCVTASIETLCVISIDRYIAITSPFYQSLLTKGRAKGIVCSVWGISALVSFLPIMMHWWRDM-K--GCCDFV--------TNRAYAIASSIISFYFPLIIMIFVYIRVFKEAQKQHGRRILSKILVAKEQKALKTLGIIMGTFTLCWLPFFLANVVNVFYRNL-IPDKLFLFLNWLGYANSAFNPIIYCRSP-DFRKAFKRLLCCPKKADRHLHTTGEFVNSLDTN---A >D2DR_HUMAN ---MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN---Q----NECII---------ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRTSMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC------------------------- >FML2_HUMAN -----------METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMT-RTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFASFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISAFWAVERLNVF------ITMAKVFLILHFIIGFTVPMSIITVCYGIIAAKI---------HRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSATSAS-------- >ACM5_MACMU -------MEGDSYHNATTVNGTPVYHQPLERHRLWEVISIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLYRAKRTPKRAGVMIGLAWLISFILWAPAILCWQYLV-VP-LDECQIQ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRNPSTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYW------------ >PE22_CANFA ----------------MGSISNNSGSEDCESREWLPSGESPAISSAMFSAGVLGNLIALALLARRWRSISLFHVLVTELVFTDLLGTCLISPVVLASYARNQLEPERRACTYFAFAMTFFSLATMLMLFAMALERYLSIGRPYYQRHVTRRGGLAVLPTIYTVSLLFCSLPLLGYGQYVQYCPGTWCFIR--------HGRTAYLQLYATLLLLLIVAVLACNFSVILNLIRMDGSRRGERVSVAEETDHLILLAIMTITFAICSLPFTIFAYMNETSS---RREKWDLQALRFLSINSIIDPWVFAIFRPPVLRLMRSVLCCRVSLRAQDATQTSSRLTFVDTS--- >5H1B_RABIT AAGSQIAVPQANLSAAHSHNCSAEGYIYQDSIALPWKVLLVLLLALFTLATTLSNAFVVATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDLWLSSDITCCTASIMHLCVIALDRYWAITDAVYSAKRTPKRAAIMIRLVWVFSICISLPPFFWR----E-E--SECLVN-------TDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRRVSLEKKKLMAARERKATKTLGIILGVFIVCWLPFFIISLVMPICKDAWFHQAIFDFFTWLGYVNSLINPIIYTMSNEDFKQAFHKLIRFKCTS--------------------- >GLHR_ANTEL HSNHTPNGTQFHQCSKIPVQCVPKSDAFHPCEDIMGYVWLTVVSFMVGAVALVANLVVALVLLTSQRRLNVTRFLMCNLAFADFILGLYIFILTSVSAVTRGWQNG-AGCKILGFLAVFSSELSLFTLVMMTIERFYAIVHAMMNARLSFRKTVRFMIGGWIFALVMAVVPLTGVSGY----KVAICLPF-----VSDATSTAYVAFLLLVNGASFISVMYLYSRMLYVVVSG---GDMEGAPKRNDSKVAKRMAILVFTDMLCWAPIAFFGLLAAFGQTLLTVTQSKILLVFFFPINSICNPFLYAFFTKAFKRELFTALSRIGFCKFRALKYNGSRSRRHHSTVNA >MSHR_OVIMO PALGSQRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPNGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFVCCLAMSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSVLSITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACRHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >P2YR_CHICK PELLAG-----------GWAAGNATTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTG----KTITCYDT-TADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSLTEYKQNGDTSL >ADMR_MOUSE LEPDNDFRDIHNWTELLHLFNQTFTDCHIEFNENTKHVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAIADLGIILSLPVWMLEVMLYETWLWGSFSCRFIHYFYLVNMYSSIFFLTCLSIDRYVTLTNTSSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLD--E--PMCLFLAPFETYSAWALAVALSATILGFLLPFLLIAVFNILTACRL---------RRQRQTESRRHCLLMWAYIVVFAICWLPYQVTMLLLTLHGTHNLLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRQHSIIITKEGSL >FSHR_BOVIN FDVMYSEFDYDLCNEVVDVTCSPEPDAFNPCEDIMGDDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY----KVSICLPM-----IDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNP------NITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEVQAQTYRSNFHPRNGHCPPA >B3AR_RAT MAPWPHKNGSLAFWSDAPTLDPSAAN---TSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVQ-E--RCCSFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQGVPRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPS-VPSGVFIALNWLGYANSAFNPLIYCRSP-DFRDAFRRLLCSYGGRGPEEPRVVTSRQNSPLNRFDG >D3DR_CERAE --------MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFN---D-P--TVCSI---------SNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRTSLPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------- >NK2R_MOUSE ----MGAHASVTDTNILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAVIWLVALALASPQCFYST---GA---TKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRPRHHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWGTPTEE----HTPSISRRVNRC >BONZ_MACNE ------MAEHDYHEDYGLNSFNDSSQEEHQDFLQFRKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WIFGQVMCKTLLGVYTINFYTSMLILTCITVDRFIVVVKATNQQAKRMTWGKVICLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DKEISTVVLATQMTLGFFLPLLAMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQTPFNLVKLIRSTHWEYTSFHYTIIVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >NK1R_MOUSE -----MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQGYYST---SR---VVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLE---IPSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY----STRYLQTQSSVY >O.2R_HUMAN ASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL-MFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTKTTLFTVCDER---WGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRKSRVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLESRKSLTTQISN >IL8A_RABIT WTWFEDEFANATGMPPVEKDYSPC----LVVTQTLNKYVVVVIYALVFLLSLLGNSLVMLVILYSRSNRSVTDVYLLNLAMADLLFALTMPIWAVSKEKG--WIFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFICLGIWALSLILSLPFFLFRQVFS-NS-SPVCYED-LGHNTAKWRMVLRILPHTFGFILPLLVMLFCYGFTLRTL---------FQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTHNDIDRALDATEILGFLHSCLNPIIYAFIGQNFRNGFLKMLAARGLISKEFLTRHR------------ >AG2S_MOUSE ------MILNSSIEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYQWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFVFPFVIILTSYTLIWKALKKA----YKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFSFLDVLIQLGDVVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKARSHAGLSTRPSD-------N >OPSD_ANGAN MNGTEGPNFYIPMSNITGVVRSPFEYPQYYLAEPWAYTILAAYMFTLILLGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTVYTSMHGYFVFGETGCNLEGYFATLGGEISLWSLVVLAIERWVVVCKPMSNFRFGENHAIMGLAFTWIMANSCAMPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFSVPLTIISFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVVIMVIAFLVCWVPYASVAWYIFTHQGSTFGPVFMTVPSFFAKSSAIYNPLIYICLNSQFRNCMITTLFCGKNPFQEEEGASTASSVSS--VSPA >O3A3_HUMAN ----MSLQKLMEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTIGGNLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRLLAICQPLYSTRMSQTVQRMLVAASWACAFTNALTHTVAMSTL---NNHFYCDLPQLSCSSTQLNELLLFVAAAFMAVAPLVFISVSYAHVVAAV--------LQIRSAEGRKKAFSTCGSHLTVVGIFYGTGVFSYMRLGSVE---SSDKDKGVGVFMTVINPMLNPLIYSLRNTDVQGALCQLLVGERSLT-------------------- >GPRC_MOUSE NLSGLPRDCIDAGAPENISAAVPSQGSVAESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAG-LGLIINFVFA-Y--LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCL-R--DESTCSVV-------RPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHIALHFLATSHYVTTRKGVSTLALILGTFAACWMPFTLYSLIADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLSQRARSP------------ >D1DR_CARAU -------------MAVLDLNLTTVIDSGFMESDRSVRVLTGCFLSVLILSTLLGNTLVCAAVTKFRHRSKVTNFFVISLAVSDLLVAVLVMPWKAVTEVAGFWPFG-AFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFYERKMTPRVAFVMISGAWTLSVLISFIPVQLKWHKAVN-PTDNCDSS--------LNRTYAISSSLISFYIPVAIMIVTYTQIYRIAQKQGSNESSFKLSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKRTCISPTTFDVFVWFGWANSSLNPIIYAFNA-DFRRAFAILLGCQRLCPGSI-SMET------------ >OPS1_SCHGR GG-F-ANQTVVDKVPPEMLYLVDPHWYQFPPMNPLWHGLLGFVIGVLGVISVIGNGMVIYIFSTTKSLRTPSNLLVVNLAFSDFLMMFTMSAPMGINCYYETWVLGPFMCELYALFGSLFGCGSIWTMTMIALDRYNVIVKGLSAKPMTNKTAMLRILFIWAFSVAWTIMPLFGWNRYVPEGNMTACGTD--YLTKDWVSRSYILVYSFFVYLLPLGTIIYSYFFILQAVSAHMNVRSAEASQTSAECKLAKVALMTISLWFFGWTPYLIINFTGIFETMK-ISPLLTIWGSLFAKANAVFNPIVYGISHPKYRAALEKKFPSLACASSSDDNTSVSDEKSEKSASA- >MSHR_CAPCA PVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDMLICGSMVSSLCFLGAIAVDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHIARKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >O3A4_HUMAN -----------MDLGNSGNDSVTKFVLLGLTETAALQPILFVIFLLAYVTTIGGTLSILAAILMETKLHSPMYFFLGNLSLPDVGCVSVTVPAMLSHFISNDRSIPYKACLSELFFFHLLAGADCFLLTIMAYDRYLAICQSLYSSRMSWGIQQALVGMSWVFSFTNALTQTVALSPL---NNHFYCDLPQLSCASVHLNGQLLFVAAAFMGVAPLVLITVSYAHVAAAV--------LRIRSAEGKKKAFSTCSSHLTVVGIFYGTGVFSYTRLGSVE---SSDKDKGIGILNTVISPMLNPLIYWTSLLDVGCISHCSSDAGVSPGPPVQSSLCLSPPPGWGGLSP >P70658 IYTSDNYSEEVG-SGDYDSNKEPC---FRDENVHFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMAD--WYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATSQRPRKLLAEKAVYVGVWIPALLLTIPDFIFADVSQGDD-RYICDRL---YPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLGSIVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKG----------GH >OPSD_AMBTI MNGTEGPNFYVPFSNKSGVVRSPFEYPQYYLAEPWQYSVLAAYMFLLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVFGGFPVTMYSSMHGYFVFGQTGCYIEGFFATMGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVMMTWIMALACAAPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFLVHFTIPLMIIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVVAFLICWVPYASVAFYIFSNQGTDFGPIFMTVPAFFAKSSAIYNPVIYIVLNKQFRNCMITTICCGKNPFGDDETTSAASSVSSSQVSPA >V2R_PIG -MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDSG--VLDCWAS---FAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSGRRPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKA-REGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQESFSARDTSS--- >5H7_HUMAN GSWAPHLLS---EVTASPAPTNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSSRLERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERPEFVLR >NTR2_RAT -----METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARARPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKH--AASRVCTVL---VSRATLQVFIQVN-VLVSFALPLALTAFLNGITVNHLMALVQARHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQSTYSFRLWGSPR >OPSD_RAJER MNGTEGENFYVPMSNKTGVVRSPFDYPQYYLGEPWMFSALAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLGGEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWSRYIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESESTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQFRNCMITTICLGKNPFEEEESTSAASSVSSSQVAPA >OPSD_CAMAB GGGF-GNQTVVDKVPPEMLHMVDAHWYQFPPMNPLWHALLGFVIGVLGVISVIGNGMVIYIFTTTKSLRTPSNLLVVNLAISDFLMMLCMSPAMVINCYYETWVLGPLFCELYGLAGSLFGCASIWTMTMIAFDRYNVIVKGLSAKPMTINGALIRILTIWFFTLAWTIAPMFGWNRYVPEGNMTACGTD--YLTKDLFSRSYILIYSIFVYFTPLFLIIYSYFFIIQAVAAHMNVRSAENQSTSAECKLAKVALMTISLWFMAWTPYLVINYSGIFETTK-ISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFQKFPSLACTTEPTG-ADTTEGNEKPAA--- >SSR4_MOUSE VED----TTWTPGINASWAPEQEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVRSAAALRH-WPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLTATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPGGE-AVACNLH---WPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALR-GGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEETALKSRGGAGCI >NY1R_.ENLA NFSTYFENLSVPNNISG---NITFPISEDCALPLPMIFTLALAYGAVIILGLSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLATIMCLPFTLIYTLMDHWIFGEVMCKLNEYIQCVSVTVSIFSLVLIAIERHQLIINPR-GWRPNNRHACFGITVIWGFAMACSTPLMMYSVLTDIG--KYVCLED---FPEDKFRLSYTTLLFILQYLGPLCFIFVCYTKIFLRLKRRNMMIRDNKYRSSETKRINIMLLSIVVGFALCWLPFFIFNLVFDWNHEACNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSREDDY---TMHTDVSKTSLK >LSHR_PIG ESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGWQTG-NGCSVAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSY----KVSICLPM-----VETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNP------ELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRK---NGFTGSNK >GPR4_HUMAN --------------------MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLFARLRRVKTAVAVSSVVWATELGANSAPLFHDEL--NH---TFCFEKPMEGWVAWMVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRG------SVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMETPLTSKRNSTA >OPSD_POMMI MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILTGFPINFLTLYVTLEHKKLRTALNLILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLGGEIALWSLVVLAVERWVVVCKPISNFRFTENHAIMGVAFSWIMAATCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFLAPLIVIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLTSWLPYASVAWYIFTHQGTEFGPLFMTIPAFFAKSSALYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >CB1R_POEGU EFYNKSLSTFKDNEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHR-KDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLYKRIVTRPKAVVAFCVMWTIAIVIAVLPLLGWNCK-K--LNSVCSDI------FPLIDETYLMFWIGVTSILLLFIVYAYMYILWKAHSHTEDQITRPDQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTIFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPTCEGTAQPLDNSMEANN-AGNVHRAA >ADMR_HUMAN AVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVE--E--PMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRL---------RQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCAQHSIIITKGDSQ >GPR6_HUMAN G-PPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAG-CGLILHFVFQ-Y--LVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCL-A--ERAACSVV-------RPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHIALHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSH----EDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSP------------ >5H1D_MOUSE SLPNQSLEGLPQEASNRSLNAT---GAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALYSKRRTAGHAAAMIAAVWIISICISIPPLFWR----H-E--SDCLVN-------TSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRKLALERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKAS--------------------- >OPSD_ORYLA MNGTEGPYFNVPMVNTTGIVRSPYEYPQYYLVSPAAYAALGAYMFFLILVGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLVFTWIMAASCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIGFLVCWLPYASVAWYIFTNQGSEFGPLFMTIPAFFAKSSSIYNPAIYICMNKQFRNCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >YDBM_CAEEL EGAGEDVDHHSLFCPKKLVGNLKGFIRNQYHQHETIQILKGSALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIVLPLSSVYAIAGEWVFPDALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVYMSKRNKRTAGIMILSVWISSALISLAPLLGWKQ--Q-TTVRQCTFL--------DLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHYRKRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIALKRLFTSEKKPSSTSRV--------------- >THRR_MOUSE LLEGRAVYLNISLPPHTPPPPFISEDASGYLTSPWLTLFMPSVYTIVFIVSLPLNVLAIAVFVLRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAAFYGNMYASIMLMTVISIDRFLAVVYPISLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTR--N--TTCHDVLSENLMQGFYSYYFSAFSAIFFLVPLIVSTVCYTSIIRCL------SSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLFLSDEAAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYSILCCKESSDPNSCNSTGDTCS-------- >H218_RAT ----MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAG-VAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCL-D--HLEACSTV------LPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSS-----HADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRCPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGPLRSSSSLERGL >CKR5_MOUSE --MDFQGSVPTYIYDIDYGMSAPC---QKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANE--WIFGNIMCKVFTGVYHIGYFGGIFFIILLTIDRYLAIVHAVALKVRTVNFGVITSVVTWVVAVFASLPEIIFTRSQK-EG-HYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMIICYSGILHTL--------FRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFNRLDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHIVKRFCKRCSIFV-------SSVY >B3AR_CANFA MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--HCCAFA--------SNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQAVPLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPS-VPSPALLALNWLGYANSAFNPLIYCRSP-DFRSAFRRLLCRCR---REEHRAAAAAPAALTSPAES >P2Y5_CHICK -----------------------MVSSNCSTEDSFKYTLYGCVFSMVFVLGLIANCVAIYIFTFTLKVRNETTTYMLNLAISDLLFVFTLPFRIYYFVVRN-WPFGDVLCKISVTLFYTNMYGSILFLTCISVDRFLAIVHPFSKTLRTKRNARIVCVAVWITVLAGSTPASFFQSTNR---EQRTCFENFPESTWKTYLSRIVIFIEIVGFFIPLILNVTCSTMVLRTLNKP----LTLSRNKLSKKKVLKMIFVHLVIFCFCFVPYNITLILYSLMRTQTAVRTMYPVTLCIAVSNCCFDPIVYYFTSDTNSELDKKQQVHQNT---------------------- >GPRO_HUMAN HASRMSVLRAKPMSNSQRLLLLSPGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISTKFRKPSVATLVICLLWALSFISITPVWLYARLIP-FP-AVGCGIR--LPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSV--PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTFVYLYNAAIS-LGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQESKGT------- >THRR_.ENLA SGEGSGDQAPVSRSARKPIRRNITKEAEQYLSSQWLTKFVPSLYTVVFIVGLPLNLLAIIIFLFKMKVRKPAVVYMLNLAIADVFFVSVLPFKIAYHLSGNDWLFGPGMCRIVTAIFYCNMYCSVLLIASISVDRFLAVVYPMSLSWRTMSRAYMACSFIWLISIASTIPLLVTEQTQK--D--TTCHDVLDLKDLKDFYIYYFSSFCLLFFFVPFIITTICYIGIIRSL------SSSSIENSCKKTRALFLAVVVLCVFIICFGPTNVLFLTHYLQEANEFLYFAYILSACVGSVSCCLDPLIYYYASSQCQRYLYSLLCCRKVSEPGSSTGQLDNCS-------- >GHSR_HUMAN SEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVG---T-D-TNECRPT---FAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRGD-VVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSINT------ >CKR3_CAVPO PEEAELETEFPGTTFYDYEFAQPC---FKVSITDLGAQFLPSLFSLVFIVGLLGNITVIVVLTKYQKLKIMTNIYLLNLAISDLLFLFTLPFWTYYVHWNK-WVFGHFMCKIISGLYYVGLFSEIFFIILLTIDRYLAIVHAVALRTRTVTFGIITSVITWVLAVLAALPEFMFYGTQG-HF-VLFCGPSYPEKKEHHWKRFQALRMNIFGLALPLLIMIICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMVVFFVFWTPYNLLLLFSAFDLSFKQLDMAKHVTEVIAHTHCCINPIIYAFVGERFQKYLRHFLHRNVTMHLSKYIPFFS-------SSIS >ADMR_RAT LAPDNDFREIHNWTELLHLFNQTFSDCRMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLYETWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLD--E--PMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRL---------RRQGQTESRRHCLLMWAYIVVFAICWLPYHVTMLLLTLHTTHNFLYFFYEITDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRQHSIIITKEGSL >GPR._MOUSE --------MDLINSSTHVINVSTSLTNSTGVPTPAPKTIIAASLFMAFIIGVISNGLYLWMLQFKMQ-RTVNTLLFFHLILSYFISTLILPFMATSFLQDNHWVFGSVLCKAFNSTLSVSMFASVFFLSAISVARYYLILHPVSQQHRTPHWASRIALQIWISATILSIPYLVFRTTHD-IS--DWESKE-HQTLGQWIHAACFVGRFLLGFLLPFLVIIFCYKRVATKM---------KEKGLFKSSKPFKVMVTAVISFFVCWMPYHVHSGLVLTKSQP-PLHLTLGLAVVTISFNTVVSPVLYLFTGENFKV-FKKSILALFNSTFSDISSTEETEI-------- >CML2_HUMAN APNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHER--YYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQ-A----CFCFA---------DVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVR----AHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHADSTEQSDVRFSS >AA2A_CANFA -------------------------------MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSS-Q-QVACLFE-----DVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQESQGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGAHGSDGEQISLR >NK2R_MESAU ----MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPITKATIAGIWLVALALASPQCFYST---GA---TKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRPRHHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEE----RTPSLSRRVNRC >PAFR_MOUSE ----------------------MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPITAQATTRKRGISLSLIIWVSIVATASYFLATDSTN-G--NITRCFEH---YEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQP---MRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDPANQTPIVSLKN >GU27_RAT --------------------------------MILNCNPFSGLFLSMYLVTVLGNLLIILAVSSNSHLHNLMYFFLSNLSFVDICFISTTIPKMLVNIHSQTKDISYIECLSQVYFLTTFGGMDNFLLTLMACDRYVAICHPLYTVIMNLQLCALLILMFWLIMFCVSLIHVLLMNEL---NPHFFCELAKVANSDTHINNVFMYVVTSLLGLIPMTGILMSYSQIASSL--------LKMSSSVSKYKAFSTCGSHLCVVSLFYGSATIVYFCSSVLHS---THKKMIASLMYTVISPMLNPFIYSLRNKDVKGALGKLFIRVASCPLWSKDFRPRQSL-------- >ET3R_.ENLA GNVLNMSPP------------PPSPCLSRAKIRHAFKYVTTILSCVIFLVGIVGNSTLLRIIYKNKCMRNGPNVLIASLALGDLFYILIAIPIISISFWLS----TGHSEYIYQLVHLYRARVYSLSLCALSIDRYRAVASWNIRSIGIPVRKAIELTLIWAVAIIVAVPEAIAFNLVELV--ILVCMLPQTSDFMRFYQEVKVWWLFGFYFCLPLACTGVFYTLMSCEMLSINGM-IALNDHMKQRREVAKTVFCLVVIFALCWLPLHVSSIFVRLSATVQLLMVMNYTGINMASLNSCIGPVALYFVSRKFKNCFQSCLCCWCHRPTLTITPMDWKANGHDLDLDR >B3AR_CAPHI MAPWPPRNSSLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLAIVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVQ-R--RCCTFA--------SNMPYALLSSSVSFYLPLLVMLFVYARVFVVATRQGVPRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPS-VSGPTFLALNWLGYANSAFNPLIYCRSP-DFQSAFRRLLCRCRPEEHLAAASPPRVLTSPAGPRQP >GP41_HUMAN -----------------------MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD--T--GTCYLE-FRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGR--------GGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICG---ESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSGGEEQRADRPAE >O.YR_RAT GTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIRDLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--RSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLRE----VFDCWAV---FIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNRAAVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNA-KEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGENSSTFVLSRRSS >OLF2_CHICK -------------MASGNCTTPTTFILSGLTDNPRLQMPLFMVFLVIYTTTLLTNLGLIALIGMDLHLQTPMYIFLQNLSFTDAAYSTVITPKMLATFLEERRTISYVGCILQYFSFVLLTTSEWLLLAVMAYDRYVAICKPLYPSIMTKAVCWRLVKGLYSLAFLNSLVHTSGLLKL---SNHFFCDNRQISSSSTTLNELLVIISGSLFVMSSIITILISYVFIILTV--------VMIRSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRSVKLF---SLDTDKIASLFYTVVIPMLNPLIYSWRNKEVKDALRRLTATSVWLH-------------------- >NTR1_MOUSE PHPQFGLETMLLALSLSNGSGLEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQN--SGGLVCTPT---VVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMEHSMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPSMSSNHAFSTSA >OLF7_RAT ------------MERRNHSGRVSEFVLLGFPAPAPLRVLLFFLSLL-YVLVLTENMLIIIAIRNHPTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFIGSKQLISFEACMTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLYPVIVSSRLCVQMAAGSWAGGFGISMVKVFLISRL---SNHFFCDVSNLSCTDMSTAELTDFVLAIFILLGPLSVTGASYMAITGAV--------MRIPSAAGRHKAFSTCASHLTVVIIFYAASIFIYARPKALS---AFDTNKLVSVLYAVIVPLFNPIIYCLRNQDVKRALRRTLHLAQDQEANTNKGSK------------ >MC5R_RAT -MNSSSHLTLLDLTLNASEDNILGQNVNNKSSACEDMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETITIYLINNDTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALYHHIMTARRSGVIIACIWTFCISCGIVFIIYYY----------------------EESKYVIVCLISMFFTMLFFMVSLYIHMFLLARNH-RIPRYNSVRQRASMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNACFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIICCHGFRRTCTLLGRY------------ >BONZ_CERAE ------MAEYDHYEDNGFNSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WIFGQVMCKTLLGIYTINFYTSMLILTCITVDRFIVVVKATNQQAKKMTWGKVICLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH-----DEEISTVVLATQMTLGFFLPLLAMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQTPFNLVKLIRSTHWEYTSFHYTIIVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKTFSASHNVEAT >SSR5_MOUSE LSLASTPSWNAS---AASSGSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSY-WPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQE-----GTCNLS-WPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAMR--VGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIERPQTTLPTRSCE >OPSR_ASTFA GD--DTTREAAFTYTNSNNTKDPFEGPNYHIAPRWVYNLATCWMFFVVVASTVTNGLVLVASAKFKKLRHPLNWILVNLAIADLLETLLASTISVCNQFFGYFILGHPMCVFEGFTVATCGIAGLWSLTVISWERWVVVCKPFGNVKFDGKMATAGIVFTWVWSAVWCAPPIFGWSRYWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCFIPLGIIILCYIAVWWAIRTVAQQQKDSESTQKAEKEVSRMVVVMIMAYCFCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQFRVCIMQLFGKKVDDG-----SEVSS------VAPA >C.C1_HUMAN ------MESSGNPESTTFFYYDLQSQPCENQAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWG--WVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLTLRVPTLRCRVLVTMAVWVASILSSILDTIFHKVLS-----SGCDYS------ELTWYLTSVYQHNLFFLLSLGIILFCYVEILRTL---------FRSRSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQQQLEYALLICRNLAFSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASFAYEGASFY--- >GALT_RAT --------------------MADIQNISLDSPGSVGAVAVPVIFALIFLLGMVGNGLVLAVLLQPGPPRSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLIYLTMYASSFTLAAVSLDRYLAVRHPLSRALRTPRNARAAVGLVWLLAALFSAPYLSYYG---GA--LELCVPA----WEDARRRALDVATFAAGYLLPVAVVSLAYGRTLCFLWAAP--AAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAPATYACRLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGRRRHRHHHR-AHPASSGPAGYPGD >ACM4_HUMAN -----MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV-VP-DNHCFIQ------FLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRSIAVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR---------------- >AG22_RAT RNITSSLPFDNLNATGTNESAFNC----SHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRT-LG--NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSREMD-------T >OPRM_MOUSE LSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYGS---IDCTLT-FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIPSTANTVDRTNH >MC4R_HUMAN GMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIIITLLNSQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALYHNIMTVKRVGIIISCIWAACTVSGILFIIYYS----------------------DDSSAVIICLITMFFTMLALMASLYVHMFLMARLH-RIPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY------------ >5H7_CAVPO STWTPRLLSGVPEVAASPSPSNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQ--N-D--KVCLIS--------QDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSSRLERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGAERPERPECVLQ >NK2R_HUMAN ----MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWAPAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAGIWLVALALASPQCFYST---GA---TKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRPGHHGANLRHLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKE----PTTSLSTRVNRC >NY1R_CAVPO TSFSQLENHSVHYNLSEEKPSFFAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALILIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWIFGEIMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYIGIAVIWVLAVASSLPFMIYQVLTDKD--KLVCFDQ---FPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNMMMRDSKYRSSESKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQICNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDY---TMHTDVSKTSLK >O.1R_RAT PGVPTSSGEPFHLPPDYED-EFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSRTRLFSVCDER---WADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQPRFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPS-----RHKS---LSLQS >YTJ5_CAEEL -------------MPNYTVPPDPADTSWDSPYSIPVQIVVWIIIIVLSLETIIGNAMVVMAYRIERNSKQVSNRYIVSLAISDLIIGIEGFPFFTVYVLNGDWPLGWVACQTWLFLDYTLCLVSILTVLLITADRYLSVCHTAYLKWQSPTKTQLLIVMSWLLPAIIFGIMIYGWQAMTQSTSGAECSAP------FLSNPYVNMGMYVAYYWTTLVAMLILYKVFSSGYQKKSQPDRLAPPNKTDTFLSASGTITFIVGFFAILWSPYYIMATVYGFCKG--IPSFLYTLSYYMCYLNSSGNPFAYALANRQFRSAFMRMFRGNFNKVA------------------ >KI01_HUMAN ---------------MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPS-SKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQS-TQ---IKCIEL--KSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFK----LKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIESTDTL------ >PD2R_HUMAN ---------------------MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQ-MVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMAEPGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDV-TSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNST------------ >C3.1_RAT --MPTSFPELDLENFEYDDSAEAC---YLGDIVAFGTIFLSIFYSLVFTFGLVGNLLVVLALTNSRKSKSITDIYLLNLALSDLLFVATLPFWTHYLISHEG--LHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAASMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKD-----NECLGDYPEVLQEIWPVLRNSEVNILGFVLPLLIMSFCYFRIVRTL---------FSCKNRKKARAIRLILLVVVVFFLFWTPYNIVIFLETLKFYNRDLRWALSVTETVAFSHCCLNPFIYAFAGEKFRRYLRHLYNKCLAVLCGRPVHAGRSRQDSILSS-L >UR2R_RAT TVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKD-WHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQ---GS--KSLCLPA----WGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLS---ASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSLQQDSGRSLSSS >5H4_MOUSE ------------------MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIRK-NSTWCVFM--------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHSRPDQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTINGSTHVLR-- >MC4R_RAT GMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALYHNIMTVRRVGIIISCIWAACTVSGVLFIIYYS----------------------DDSSAVIICLITMFFTMLVLMASLYVHMFLMARLH-RIPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY------------ >OLF2_CANFA -------------MDGKNCSSVNEFLLVGISNKPGVKVTLFITFLIVYLIILVANLGMIILIRMDSQLHTPMYFFLSHLSFSDARYSTAVGPRMLVGFIAKNKSIPFYSCAMQWLVFCTFVDSECLLLAVMAFDRYKAISHPLYTVSMSSRVCSLLMAGVYLVGIMDASVNTILTFRL---CNHFFCDVPLLSCSDTQVNELVIFTIFGFIELITLSGLFVSYCYIILAV--------RKINSAEGRFKAFSTCTSHLTAVAIFQGTMLFMYFRPSSSY---SLDQDKIISLFYSLVIPMLNPLIYSLRNKDVKEALKKLKNKKWFH--------------------- >AG2S_.ENLA ----MLSNISAGENSEVEKIVVKC---SKSGMHNYIFITIPIIYSTIFVVGVFGNSLVVIVIYSYMKMKTMASVFLMNLALSDLCFVITLPLWAVYTAMHYHWPFGDLLCKIASTAITLNLYTTVFLLTCLSIDRYSAIVHPMSRIRRTVMVARLTCVGIWLVAFLASLPSVIYRQIFI-TN--TVCALV-YHSGHIYFMVGMSLVKNIVGFFIPFVIILTSYTLIGKTLKEV------YRAQRARNDDIFKMIVAVVLLFFFCWIPHQVFTFLDVLIQMDDIVDTGMPITICIAYFNSCLNPFLYGFFGKKFRKHFLQLIKYIPPKMRTHASVNTRLSD-------T >OPRD_MOUSE SSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPGA---VVCMLQ-FPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL-SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRVTACTPSDGPG >CKR5_PYGNE ----MDYQVSSPTYDIDYYTSEPC---QKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQR-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLIMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OPSD_GAMAF MNGTEGPYFYVPMVNTTGIVRSPYEYPQYYLVSPAAYACLGAYMFFLILVGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNLEGYFATLGGEIGLWSLVVLAVERWLVVCKPISNFRFTENHAIMGLVFTWIMANACAAPPLLGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFICHFCIPLVVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVILVIGFLVCWTPYASVAWYIFSNQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTASSVSSSSVSPA >LSHR_CALJA ESGQSGWDYDYGFHLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGWQTG-SGCNTAGFFTVFASELSVYTLTVITLERWHTITYAILDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNY----KVSICFPM-----VETTLSQIYILTILILNVVAFIIICACYIKIYFAVRNP------ELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKMPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFRRDFFLLLGKFGCCKHRAELYRRSNYKNGFTGSSK >O1F1_HUMAN -------------MSGTNQSSVSEFLLLGLSRQPQQQHLLFVFFLSMYLATVLGNLLIILSVSIDSCLHTPMYFFLSNLSFVDICFSFTTVPKMLANHILETQTISFCGCLTQMYFVFMFVDMDNFLLAVMAYDHFVAVCHPLYTAKMTHQLCALLVAGLWVVANLNVLLHTLLMAPL---STHFFCDVTKLSCSDTHLNEVIILSEGALVMITPFLCILASYMHITCTV--------LKVPSTKGRWKAFSTCGSHLAVVLLFYSTIIAVYFNPLSSH---SAEKDTMATVLYTVVTPMLNPFIYSLRNRYLKGALKKVVGRVVFSV-------------------- >GALT_HUMAN --------------------MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLSRALRTPRNARAAVGLVWLLAALFSAPYLSYYG---GA--LELCVPA----WEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAP--AAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRGPPGCPGDARPS >A2AA_CAVPO ----MGSLQPDSGNASWNGTEGPGGGTRATPYSLQVTVTLVCLVGLLILLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEK-AQ-P--PRCEIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRRGGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >A2AA_RAT ----MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGQ-P--PSCKIN--------DQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRRAGASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCP--VPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV------------------ >OLF4_CANFA -------------MELENDTRIPEFLLLGFSEEPKLQPFLFGLFLSMYLVTILGNLLLILAVSSDSHLHTPMYFFLANLSFVDICFTCTTIPKMLVNIQTQRKVITYESCIIQMYFFELFAGIDNFLLTVMAYDRYMAICYPLYMVIMNPQLCSLLLLVSWIMSALHSLLQTLMVLRL---SPHFFCELNQLACSDTFLNNMMLYFAAILLGVAPLVGVLYSYFKIVSSI--------RGISSAHSKYKAFSTCASHLSVVSLFYCTSLGVYLSSAAPQ---STHTSSVASVMYTVVTPMLNPFIYSLRNKDIKGALNVFFRGKP----------------------- >SSR2_RAT QFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDLNETTETQRTLL >BRS3_SHEEP QTLISTTNDTESSSSVVPNDSTNKRRTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDVTHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLRQPPNAILKTCAKAGCIWIMSMIIALPEAIFSNVYTVT--FKACASY---VSERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSIPTQRHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYRSFTSQTTVHLFVTIISRILAFSNSCVNPFALYWLSNTFQQHFKAQLFCCKAGRPDPTAANTMGRVPGAASTQM >ETBR_BOVIN SSATPQIPRGGRMAGIPPR--TPPPCDGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAKDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDIITRI--LRICLLHQKTAFMQFYKTAKDWWLFSFYFCLPLAITALFYTLMTCEMLRKSGM-IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFE-EKQSLEFKANDHGYDNFR >FML1_HUMAN -----------METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMT-RTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTASWPEERLKVA------ITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKI---------HKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTAS---------- >V1AR_MOUSE SSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFVLSIPQYFIFSVIETK--AQDCWAT---FIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHIWRNLLVVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSTSYSNNRSPTNS >OPSB_BOVIN --MSKMSEEEEFLLFKNISLVGPWDGPQYHLAPVWAFHLQAVFMGFVFFVGTPLNATVLVATLRYRKLRQPLNYILVNVSLGGFIYCIFSVFIVFITSCYGYFVFGRHVCALEAFLGCTAGLVTGWSLAFLAFERYIIICKPFGNFRFSSKHALMVVVATWTIGIGVSIPPFFGWSRFVPEGLQCSCGPDWYTVGTKYYSEYYTWFLFIFCYIVPLSLICFSYSQLLGALRAVAAQQQESASTQKAEREVSHMVVVMVGSFCLCYTPYAALAMYIVNNRNHGVDLRLVTIPAFFSKSACVYNPIIYCFMNKQFRACIMEMVCGKPMTD---ESELSSTVSSSQVGPN- >APJ_MOUSE -----------MEDDGYNYYGADNQSECDYADWKPSGALIPAIYMLVFLLGTTGNGLVLWTVFRTSRKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVNARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDAQCY-MDYSMVA-TSNSEWAWEVGLGVSSTAVGFVVPFTIMLTCYFFIAQTIAGHFR--KERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLIFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCDQSGCKGTPHSSSSSGHSQGPGPNM >O1G1_HUMAN -------------MEGKNLTSISECFLLGFSEQLEEQKPLFGSFLFMYLVTVAGNLLIILVIITDTQLHTPMYFFLANLSLADACFVSTTVPKMLANIQIQSQAISYSGCLLQLYFFMLFVMLEAFLLAVMAYDCYVAICHPLYILIMSPGLCIFLVSASWIMNALHSLLHTLLMNSL---SPHFFCDINSLSCTDPFTNELVIFITGGLTGLICVLCLIISYTNVFSTI--------LKIPSAQGKRKAFSTCSSHLSVVSLFFGTSFCVDFSSPSTH---SAQKDTVASVMYTVVTPMLNPFIYSLRNQEIKSSLRKLIWVRKIHSP------------------- >CKR2_HUMAN FIRNTNESGEEVTTFFDYDYGAPC---HKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANE--WVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQK-ED-VYVCGPY----FPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTL--------LRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPV-------KVTT >5H2A_CRIGR NSSDASNWTIDGENRTNLSFEGYLPPTCLSILHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHSRFNSRTKAFLKIIAVWTISVGVSMPIPVFGLQD-VF---GSCLL---------ADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEEPGGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESHVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILAYKSSQLQAGQN >TRFR_MOUSE ------------MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--NA-SCGYKIS------RNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNLNLNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVKESDRFSTELED >OPSH_CARAU MNGTEGNNFYVPLSNRTGLVRSPFEYPQYYLAEPWQFKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGAIMVCFGFTVTFYTAINGYFALGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGSFKFSSTHASAGIAFTWVMAMACAAPPLVGWSRYIPEGIQCSCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKAAAAQQQDSASTQKAEREVTKMVILMVLGFLVAWTPYATVAAWIFFNKGAAFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTLFCGKNPLGDEESSTVSS------VSPA >A2AB_RAT --------------------MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPCRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCELN--------QEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSGVAWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW------------------ >TA2R_CERAE --MWPNG-----------SSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQTRSSFLTFLCGLVLTDFLGLLVTGAIVVSQHAALFVDPGCRLCRFMGVVMIFFGLSPLLLGATMASERFLGITRPFRPVVTSQRRAWATVGLVWAAALALGLLPLLGLGRYTVQYPGSWCFLT----LGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGEAAQQRPRDSEVEMMAQLLGIMLVASVCWLPLLVFIAQTVLRNPPRATEQELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQ------------ >SSR2_HUMAN PLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPISAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSWG--RSSCTIN-WPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIR-VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDLNETTETQRTLL >ACM4_.ENLA ----MENDTWENESSASNHSIDETIVEIPGKYQTMEMIFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYSLYIIKGYWPLGPIVCDLWLALDYVVSNASVMNLLIISLER-FCVTKPLYPARRTTKMAGLMIAAAWLLSFELWAPAILFWQFIV-VP-SGECYIQ------FLSNPAVTFGTAIAAFYLPVVIMTILYIHISLASRSRSIAVRKKRQMAAREKKVTRTIFAILLAFIITWTPYNVMVLINTFCQTC-IPETIWYIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYKSIGTAR---------------- >Y..5_CAEEL SVNESCDNYVEIFNKINYFFRDDQVINGTEYSPKEFGYFITFAYMLIILFGAIGNFLTIIVVILNPAMRTTRNFFILNLALSDFFVCIVTAPTTLYTVLYMFWPFSRTLCKIAGSLQGFNIFLSTFSIASIAVDRYVLIIFPT-KRERQQNLSFCFFIMIWVISLILAVPLLQASDLTPCDLALYICHEQEIWEKMIISKGTYTLAVLITQYAFPLFSLVFAYSRIAHRMKLRTTNSQRRRSVVERQRRTHLLLVCVVAVFAVAWLPLNVFHIFNTFELVN-FSVTTFSICHCLAMCSACLNPLIYAFFNHNFRIEFMHLFDRVGLRSLRVVIFGEMRTEFRSRGGCK >GRHR_CLAGA TLLLSNPTNVLDNSSVLNVSVSPPVLKWETPTFTTAARFRVAATLVLFVFRAASNLSVLLSVTRGRGLASHLRPLIASLASADLVMTFVVMPLDAVWNVTVQWYAGDAMCKLMCFLKLFAMHSAAFILVVVSLDRHHAILHPL-DTLDAGRRNRRMLLTAWILSLLLASPQLFIFRAIKVD--FVQCATH--SFQQHWQETAYNMFHFVTLYVFPLLVMSLCYTRILVEINRQGEPRSGTDMIPKARMKTLKMTIIIVASFVICWTPYYLLGIWYWFQPQMVIPDYVHHVFFVFGNLNTCCDPVIYGFFTPSFRADLSRCFCWRNQNASAKSLPHFSGEAESDLGSGD >CKR5_HUMAN ----MDYQVSSPIYDINYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >OPSD_NEOSA MNGTEGPYFYVPMVNTTGVVRSPYEYPQYYLVNPAAFAVLGAYMFFLIIFGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVIGGFTTTMYSSMHGYFVLGRLGCNLEGFSATLGGMISLWSLAVLAIERWVVVCKPTSNFRFGENHAIMGVSLTWTMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFFCHFMVPLIIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVILMVIGYLVCWLPYASVAWFIFTHQGSEFGPLFMTIPAFFAKSSSIYNPVIYICMNKQFRNCMITTLFCGKNPF---EGEEETEASSASSVSPA >A2AB_HUMAN -------------------------MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGD-Q-----PQCKLN--------QEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSGAIWWRRRAHVTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW------------------ >CKR4_MOUSE VTDTTQDETVYNSYYFYESMPKPC---TKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQ--WVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT-EH-HTYCKTQ-YSVNSTTWKVLSSLEINVLGLLIPLGIMLFWYSMIIRTL---------QHCKNEKKNRAVRMIFGVVVLFLGFWTPYNVVLFLETLVELERYLDYAIQATETLGFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFMS------SSSY >A1AD_HUMAN GSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEP--VP--RFCGIT--------EEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTHTFLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRASTSG-LRQDCA >C3AR_HUMAN --------------MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQ-RTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPICQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFT-ED-YNLGQFT-DDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRM--------QRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPEKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSVIS--------- >AG2R_HUMAN ------MILNSSTEDGIKRIQDDC---PKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFF-TN--TVCAFH-YESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA----YEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTRPSD-------N >CKR5_PANTR ----MDYQVSSPIYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >PF2R_MOUSE --MSMNS---------SKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYN--TEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELKVAAISESPAA >OPSB_ORYLA VEFPDDFWIPIPLDTNNVTALSPFLVPQDHLGSPTIFYSMSALMFVLFVAGTAINLLTIACTLQYKKLRSHLNYILVNMAVANLIVASTGSSTCFVCFAFKYMVLGPLGCKIEGFTAALGGMVSLWSLAVIAFERWLVICKPLGNFVFKSEHALLCCALTWVCGLCASVPPLVGWSRYIPEGMQCSCGPDWYTTGNKFNNESFVMFLFCFCFAVPFSIIVFCYSQLLFTLKMAAKAQADSASTQKAEKEVTRMVVVMVVAFLVCYVPYASFALWVINNRGQTFDLRLATIPSCVSKASTVYNPVIYVLLNKQFRLCMKKMLGMSADED---EESSTSKVGPS------ >CCKR_RABIT ASLLGNASGIPPPCELGLDNETLFCLDQPPPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAISDLMLCLFCMPFNLIPNLLKDFIFGSALCKTTTYLMGTSVSVSTLNLVAISLERYGAICKPLSRVWQTKSHALKVIAATWCLSFAIMTPYPIYN----NNQTANMCRFL---LPSDVMQQAWHTFLLLILFLIPGIVMMVAYGMISLELYQGRVSSSSSAATLMAKKRVIRMLMVIVVLFFLCWMPIFSANAWRAYDTVSRLSGTPISFILLLSYTSSCVNPIIYCFMNRRFRLGFMATFPCCPNPGPPGPRAEATTRASLSRYSYS >BRB1_HUMAN SSWPPLELQSSNQSQLFPQNATAC--DNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMSGRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA-LN--TACILL---LPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTR---VSRTRVRGPKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPK---------LAPI-------S >TRFR_RAT ------------MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLN--DA-SCGYKIS------RNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNMNLNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVKESDRFSTELDD >AG22_HUMAN KNITSGLHFGLVNISGNNESTLNC----SQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRT-LG--NACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKT----NSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSREME-------T >VU51_HSV7J -----------------MKNIDLTNWKLLAEIYEYLFFFSFFFLCLLVIIVVKFNNSTVGR-E--------YTFSTFSGMLVYILLLPVKMGMLTKM-----WDVSTDYCIILMFLSDFSFIFSSWALTLLALERINNFSFSEIKVNETKILKQMSFPIIWVTSIFQAVQISMKYKKSQ---EDDYCLLA--------IRSAEEAWILLMYTVVIPTFIVFFYVLNKRFL-----------FLERDLNSIVTHLSLFLFFGALCFFPASVLNEFNCN----RLFYGLHELLIVCLELKIFYVPTMTYIISCENYRLAAKAFFCKCFKPCFLMPSLRSTQF-------- >PAR3_MOUSE -WTGATTTIKAECPEDSISTLHVNNATIGYLRSSLSTQVIPAIYILLFVVGVPSNIVTLWKLSLRTK-SISLVIFHTNLAIADLLFCVTLPFKIAYHLNGNNWVFGEVMCRITTVVFYGNMYCAILILTCMGINRYLATAHPFYQKLPKRSFSLLMCGIVWVMVFLYMLPFVILKQEYH--E--TTCHDVDACESPSSFRFYYFVSLAFFGFLIPFVIIIFCYTTLIHKL----------KSKDRIWLGYIKAVLLILVIFTICFAPTNIILVIHHANYYYDSLYFMYLIALCLGSLNSCLDPFLYFVMSKVVDQLNP------------------------------ >GPRC_HUMAN NLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAG-IGLITNFVFA-Y--LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCL-R--DESTCSVV-------RPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHIALHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSP------------ >BRB2_CAVPO ---MFNITSQVSALNATLAQGNSC---LDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKD-HN--TACLII---YPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNN---EMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQLRTS-------I >P2YR_RAT AAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTG----KTVTCYDS-TSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIY------KDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSLSEFKQNGDTSL >PF2R_SHEEP --MSTNN---------SVQPVSPASELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYK--TDQIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELKVAAISDLPVT >GPRO_RAT QTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISTKFRKPSMATLVICLLWALSFISITPVWLYARLIP-FP-AVGCGIR--LPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSV--PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTFVYLYNAAIS-LGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQESKGT------- >ML1._HUMAN ---------MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT-IEYDP-TYTCIFN------YLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD-AGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFPGLISARTLARARAHAR >AVT_CATCO -------------MGRIANQTTASNDTDPFGRNEEVAKMEITVLSVTFFVAVIGNLSVLLAMHNTKKKSSRMHLFIKHLSLADMVVAFFQVLPQLCWEITFRFYGPDFLCRIVKHLQVLGMFASTYMMVMMTLDRYIAICHPLKTLQQPTQRAYIMIGSTWLCSLLLSTPQYFIFSLSESY--VYDCWGH---FIEPWGIRAYITWITVGIFLIPVIILMICYGFICHSIWKNMIGVSSVTIISRAKLRTVKMTLVIVLAYIVCWAPFFIVQMWSVWDENFDSENAAVTLSALLASLNSCCNPWIYMLFSGHLLYDFLRCFPCCKKPRNMLQKEDSTLLTKLAAGRMT >ACM3_PIG N---------ISQAAGNFSSPNGTTSDPLGGHTIWQVVFIAFLTGILALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLYRAKRTTKRAGVMIGLAWVISFILWAPAILFWQYFV-VP-PGECFIQ------FLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRKTRTKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQHKRVPEQAL--- >MSHR_ALCAA PVLGSQRRLLGSLNCTPPATFSLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAAAVVQQLDNVIDVLICGSMVSSLCFLGAIAMDRYISIFYALYHSVVTLPRAWRIIAAIWVASILTSLLFITYYY----------------------NNHTVVLLCLVGFFIAMLALMAILYVHMLARACQHIARKRQHPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW----------------------- >GP72_MOUSE TGPNASSHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPL-KPRISITKGVIYIAVIWVMATFFSLPHAICQKLFT--EVRSLCLPD-FPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCGDVTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAI-HTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPVAWTEKSHGRRA >ACM5_RAT --------MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLV-VP-PDECQIQ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRNLSTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC-VPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYW------------ >CKR5_PONPY ----MDYQVSSPTYDIDYYTSEPC---QKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQ--WDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQK-EG-HYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL--------LRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFA-------SSVY >GASR_CANFA GASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVVCKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLARVWQTRSHAARVIIATWMLSGLLMVPYPVYTAVQP---A-LQCVHR---WPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGPGPPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANTWRAFDSSGALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRPLPSIASLSRLSYT >TLR2_DROME TLSTDQPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPL-QPRMSKRCNLAIAAVIWLASTLISCPMMIIYR----NR--TVCYPEDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSTIGTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAIPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRYSCSGSPDHNRI >D2DR_MELGA ------MDPLNLSWYNTGDRNWSEPVNESSADQKPQYNYYAVLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAAAMPMNTRYSSKRRVTVMIACVWVLSFAISSPILFGLN---E----RECII---------ANPAFVVYSSVVSFYVPFIVTLLVYVQIYMVLRRRSTLMNRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCN-IPPAMYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC------------------------- >EDG2_BOVIN QPQFTAMNEQQCFSNESIAFFYNRSGKYLATEWNTVTKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG-LAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTVSVANLLAIAIERHITVFRMQLHARMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCI-C--DIENCSNM------APLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRRMSSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQC-DVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENTSGPTEGSNHTILAGVHSND >NY2R_BOVIN EEMKVDQFGPGHTTLPGELAPDSEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL-ESKISKQISFLIIGLAWGVSALLASPLAIFREYSLFE--IVACTEKWPGEEKGIYGTIYSLSSLLILYVLPLGIISFSYTRIWSKLKNHSPG-AAHDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSE---AKKHLQVTKNNG >HH1R_RAT ----------MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFM--EL-EDKCETD------FYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHLRSQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSC-CSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS-----------------------""" gpcr_aln = ArrayAlignment(data=_fasta_to_dict(gpcr_ungapped), moltype=PROTEIN) myos_data = """>gi|107137|pir||A37102 LSRIITRIQA >gi|11024712|ref|NP-060003.1| LAQLITRTQA >gi|11276950|pir||A59286 LSRIITRIQA >gi|11276952|pir||A59293 LAQLITRTQA >gi|11276954|pir||A59234 LSLIITRIQA >gi|11276955|pir||A59236 LSSIFKLIQA >gi|11321579|ref|NP-003793.1| LVTLMTSTQA >gi|11342672|ref|NP-002461.1| LAKLITRTQA >gi|1197168|dbj|BAA08111.1| LSSIFKLIQA >gi|12003423|gb|AAG43570.1|AF21 LVTLMTRTQA >gi|12003425|gb|AAG43571.1|AF21 LVTLMTRTQA >gi|12003427|gb|AAG43572.1|AF21 LVTLMTRTQA >gi|12053672|emb|CAC20413.1| LSRIITRIQA >gi|12060489|dbj|BAB20630.1| LSRIITRIQA >gi|12657350|emb|CAC27776.1| LASLVTLTQA >gi|12657354|emb|CAC27778.1| LAKLVTMTQA >gi|127741|sp|P02563|MYH6-RAT LSRIITRIQA >gi|127748|sp|P02564|MYH7-RAT LSRIITRIQA >gi|127755|sp|P12847|MYH3-RAT LAKLITRTQA >gi|1289512|gb|AAC59911.1| LSLIITRIQA >gi|1289514|gb|AAC59912.1| LSLIITRIQA >gi|13431707|sp|Q28641|MYH4-RAB LAQLITRTQA >gi|13431711|sp|Q90339|MYSS-CYP LALLVTMTQA >gi|13431716|sp|Q9UKX2|MYH2-HUM LAQLITRTQA >gi|13431717|sp|Q9UKX3|MYHD-HUM LVTLMTSTQA >gi|13431724|sp|Q9Y623|MYH4-HUM LAQLITRTQA >gi|1346637|sp|P02565|MYH3-CHIC LAQLITRTQA >gi|13560269|dbj|BAB40920.1| LAQLMTRTQA >gi|13560273|dbj|BAB40922.1| LSRIITRIQA >gi|13638390|sp|P12882|MYH1-HUM LAQLITRTQA >gi|14017756|dbj|BAB47399.1| LSLIITRIQA >gi|15384839|emb|CAC59753.1| LATLVTMTQA >gi|1581130|prf||2116354A LSRIITRIQA >gi|1619328|emb|CAA27817.1| LAKLITRTQA >gi|16508127|gb|AAL17913.1| LSRIITRIQA >gi|1698895|gb|AAB37320.1| LSRIITRIQA >gi|17907763|dbj|BAB79445.1| LAKILTMLQA >gi|179508|gb|AAA51837.1| LSRIITRIQA >gi|179510|gb|AAA62830.1| LSRIITRIQA >gi|18859641|ref|NP-542766.1| LSRIITRIQA >gi|191618|gb|AAA37159.1| LSRIITRIQA >gi|191620|gb|AAA37160.1| LSRIITRIQA >gi|191622|gb|AAA37161.1| LSRIITRIQA >gi|191624|gb|AAA37162.1| LSRIITRIQA >gi|2119306|pir||I49464 LSRIITRIQA >gi|2119307|pir||I48175 LSRIITRIQA >gi|2119308|pir||I48153 LSRIITRIQA >gi|212376|gb|AAA48972.1| LAQLITRTQA >gi|21623523|dbj|BAC00871.1| LAALVGMVQA >gi|21743235|dbj|BAB40921.2| LAQLITRTQA >gi|21907898|dbj|BAC05679.1| LAQIITRTQA >gi|21907900|dbj|BAC05680.1| LAQIITRTQA >gi|21907902|dbj|BAC05681.1| LSRIITRIQA >gi|219524|dbj|BAA00791.1| LSRIITRIQA >gi|22121649|gb|AAM88909.1| LAQIITRTQA >gi|23379831|gb|AAM88910.1| LAQLITRTQA >gi|2351219|dbj|BAA22067.1| LSHLVTMTQA >gi|2351221|dbj|BAA22068.1| LVNLVTMTQA >gi|2351223|dbj|BAA22069.1| LALLVTMTQA >gi|27764861|ref|NP-002462.1| LSRIITRMQA >gi|297024|emb|CAA79675.1| LSRIITRMQA >gi|3024204|sp|Q02566|MYH6-MOUS LSRIITRIQA >gi|3041706|sp|P13533|MYH6-HUMA LSRIITRMQA >gi|3041708|sp|P13540|MYH7-MESA LSRIITRIQA >gi|3043372|sp|P11055|MYH3-HUMA LAKLITRTQA >gi|34870884|ref|XP-213345.2| LAQLITRTQA >gi|34870892|ref|XP-340820.1| LAQIITRTQA >gi|37720046|gb|AAN71741.1| LARILTGIQA >gi|38091410|ref|XP-354614.1| LAKLITRTQA >gi|38091413|ref|XP-354615.1| LAQLITRTQA >gi|38177589|gb|AAF00096.2|AF11 LSLIISGIQA >gi|38347761|dbj|BAD01606.1| LSLLLTRTQA >gi|38347763|dbj|BAD01607.1| LSLLLTRTQA >gi|38488753|ref|NP-942118.1| LARILTGIQA >gi|3915779|sp|P13539|MYH6-MESA LSRIITRIQA >gi|402372|gb|AAA62313.1| LSRIITRIQA >gi|402374|gb|AAB59701.1| LSRIITRIQA >gi|41350446|gb|AAS00505.1| LAALVTMTQA >gi|41386691|ref|NP-776542.1| LAQLITRTQA >gi|41386711|ref|NP-777152.1| LSRIITRIQA >gi|42476190|ref|NP-060004.2| LAQLITRTQA >gi|42662294|ref|XP-371398.2| LAKVLTLLQA >gi|45382109|ref|NP-990097.1| LAKILTMIQA >gi|45383005|ref|NP-989918.1| LAKILTMLQA >gi|45383668|ref|NP-989559.1| LAQLITRTQA >gi|4557773|ref|NP-000248.1| LSRIITRIQA >gi|45595719|gb|AAH67305.1| LAQLITRTQA >gi|476355|pir||A46762 LSRIITRIQA >gi|4808809|gb|AAD29948.1| LVTLMTSTQA >gi|4808811|gb|AAD29949.1| LAQLITRTQA >gi|4808813|gb|AAD29950.1| LAQLITRTQA >gi|4808815|gb|AAD29951.1| LAQLITRTQA >gi|5360746|dbj|BAA82144.1| LAQLITRTQA >gi|5360748|dbj|BAA82145.1| LAQLITRTQA >gi|5360750|dbj|BAA82146.1| LAQLITRTQA >gi|547966|sp|P12883|MYH7-HUMAN LSRIITRIQA >gi|56655|emb|CAA34064.1| LSRIITRIQA >gi|6093461|sp|P79293|MYH7-PIG LSRIITRIQA >gi|6683485|dbj|BAA89233.1| LAQLITRTQA >gi|6708502|gb|AAD09454.2| LAKIMTMLQC >gi|7209643|dbj|BAA92289.1| LATLVTMTQA >gi|7248371|dbj|BAA92710.1| LAKILTMIQA >gi|7669506|ref|NP-005954.2| LAQLITRTQA >gi|8393804|ref|NP-058935.1| LSRIITRIQA >gi|8393807|ref|NP-058936.1| LSRIITRIQA >gi|86358|pir||A29320 LAQLITRTQA >gi|88201|pir||S04090 LAKLITRTQA >gi|92498|pir||S06005 LSRIITRIQA >gi|92499|pir||S06006 LSRIITRIQA >gi|92509|pir||A24922 LAKLITRTQA >gi|940233|gb|AAA74199.1| LAQLITRTQA >gi|9800486|gb|AAF99314.1|AF272 LAQLITRTQA >gi|9800488|gb|AAF99315.1|AF272 LAQLITRTQA >gi|9971579|dbj|BAB12571.1| LAALVTMTQA""" myos_aln = ArrayAlignment(data=_fasta_to_dict(myos_data), moltype=PROTEIN) # a randomly generated tree to use in tests tree20_string = "(((0:0.5,1:0.5):0.5,(((2:0.5,3:0.5):0.5,(4:0.5,(5:0.5,6:0.5):0.5):0.5):0.5,((7:0.5,8:0.5):0.5,((9:0.5,((10:0.5,11:0.5):0.5,12:0.5):0.5):0.5,13:0.5):0.5):0.5):0.5):0.5,(((14:0.5,(15:0.5,16:0.5):0.5):0.5,17:0.5):0.5,(18:0.5,19:0.5):0.5):0.5);"