File: ThresholdImage.cxx

package info (click to toggle)
ants 2.5.4%2Bdfsg-1
  • links: PTS, VCS
  • area: main
  • in suites: forky, sid, trixie
  • size: 11,672 kB
  • sloc: cpp: 85,685; sh: 15,850; perl: 863; xml: 115; python: 111; makefile: 68
file content (554 lines) | stat: -rw-r--r-- 18,299 bytes parent folder | download
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
/*=========================================================================

  Program:   Advanced Normalization Tools

  Copyright (c) ConsortiumOfANTS. All rights reserved.
  See accompanying COPYING.txt or
 https://github.com/stnava/ANTs/blob/master/ANTSCopyright.txt for details.

     This software is distributed WITHOUT ANY WARRANTY; without even
     the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR
     PURPOSE.  See the above copyright notices for more information.

=========================================================================*/

#include "antsUtilities.h"
#include "antsAllocImage.h"
#include <algorithm>

#include <cstdlib>
#include <ctime>
#include <iostream>
#include <fstream>

#include "itkArray.h"
#include "itkExtractImageFilter.h"
#include "itkImage.h"
#include "ReadWriteData.h"
#include "itkImageRegionIteratorWithIndex.h"
#include "itkKdTreeBasedKmeansEstimator.h"
#include "itkLabelStatisticsImageFilter.h"
#include "itkLinearInterpolateImageFunction.h"
#include "itkListSample.h"
#include "itkMinimumDecisionRule.h"
#include "itkMultiplyImageFilter.h"
#include "itkNeighborhoodIterator.h"
#include "itkOtsuMultipleThresholdsImageFilter.h"
#include "itkResampleImageFilter.h"
#include "itkSampleClassifierFilter.h"
#include "itkWeightedCentroidKdTreeGenerator.h"

namespace ants
{
template <typename TImage>
typename TImage::Pointer
MultiplyImage(typename TImage::Pointer image1, typename TImage::Pointer image2)
{
  std::cout << " Multiply " << std::endl;
  // Begin Multiply Images
  using tImageType = TImage;
  //  output will be the speed image for FMM
  using MultFilterType = itk::MultiplyImageFilter<tImageType, tImageType, tImageType>;
  typename MultFilterType::Pointer filter = MultFilterType::New();
  filter->SetInput1(image1);
  filter->SetInput2(image2);
  filter->Update();
  return filter->GetOutput(); // this is the speed image

  // write a function to threshold the speedimage so
  // if the dist is g.t. D then speed = 1
}

template <typename TImage>
typename TImage::Pointer
BinaryThreshold_AltInsideOutside_threashold(typename TImage::PixelType low,
                                            typename TImage::PixelType high,
                                            typename TImage::PixelType insideval,
                                            typename TImage::PixelType outsideval,
                                            typename TImage::Pointer   input)
{

  using PixelType = typename TImage::PixelType;
  // Begin Threshold Image
  using InputThresholderType = itk::BinaryThresholdImageFilter<TImage, TImage>;
  typename InputThresholderType::Pointer inputThresholder = InputThresholderType::New();

  inputThresholder->SetInput(input);
  inputThresholder->SetInsideValue(insideval);
  inputThresholder->SetOutsideValue(outsideval);

  inputThresholder->SetLowerThreshold((PixelType)low);
  inputThresholder->SetUpperThreshold((PixelType)high);
  inputThresholder->Update();

  return inputThresholder->GetOutput();
}

template <typename TImage>
typename TImage::Pointer
LabelSurface(typename TImage::PixelType foreground, typename TImage::PixelType newval, typename TImage::Pointer input)
{
  std::cout << " Label Surf " << std::endl;
  using ImageType = TImage;
  enum
  {
    ImageDimension = ImageType::ImageDimension
  };
  // ORIENTATION ALERT: Original code set spacing & origin without
  // setting directions.
  typename ImageType::Pointer Image = AllocImage<ImageType>(input);

  using iteratorType = itk::NeighborhoodIterator<ImageType>;

  typename iteratorType::RadiusType rad;
  for (int j = 0; j < ImageDimension; j++)
  {
    rad[j] = 1;
  }
  iteratorType GHood(rad, input, input->GetLargestPossibleRegion());

  GHood.GoToBegin();

  //  std::cout << " foreg " << (int) foreground;
  while (!GHood.IsAtEnd())
  {
    typename TImage::PixelType p = GHood.GetCenterPixel();
    typename TImage::IndexType ind = GHood.GetIndex();
    typename TImage::IndexType ind2;
    if (p == foreground)
    {
      bool atedge = false;
      for (int i = 0; i < GHood.Size(); i++)
      {
        ind2 = GHood.GetIndex(i);
        float dist = 0.0;
        for (int j = 0; j < ImageDimension; j++)
        {
          dist += (float)(ind[j] - ind2[j]) * (float)(ind[j] - ind2[j]);
        }
        dist = sqrt(dist);
        if (GHood.GetPixel(i) != foreground && dist < 1.1f)
        {
          atedge = true;
        }
      }
      if (atedge && p == foreground)
      {
        Image->SetPixel(ind, newval);
      }
      else if (p == foreground)
      {
        Image->SetPixel(ind, 0);
      }
    }
    ++GHood;
  }

  return Image;
}

template <typename TImage, typename TMaskImage>
typename TImage::Pointer
OtsuThreshold(int NumberOfThresholds, typename TImage::Pointer input, typename TMaskImage::Pointer maskImage)
{
  // std::cout << " Otsu Thresh with " << NumberOfThresholds << " thresholds" << std::endl;

  if (maskImage.IsNull())
  {
    // Begin Threshold Image
    using InputThresholderType = itk::OtsuMultipleThresholdsImageFilter<TImage, TImage>;
    typename InputThresholderType::Pointer inputThresholder = InputThresholderType::New();

    inputThresholder->SetInput(input);
    /*
    inputThresholder->SetInsideValue(  replaceval );
    int outval=0;
    if ((float) replaceval == (float) -1) outval=1;
    inputThresholder->SetOutsideValue( outval );
    */
    inputThresholder->SetNumberOfThresholds(NumberOfThresholds);

    inputThresholder->Update();

    return inputThresholder->GetOutput();
  }
  else
  {
    using ImageType = TImage;
    using MaskImageType = TMaskImage;
    using PixelType = float;

    unsigned int numberOfBins = 200;
    int          maskLabel = 1;

    itk::ImageRegionIterator<ImageType>     ItI(input, input->GetLargestPossibleRegion());
    itk::ImageRegionIterator<MaskImageType> ItM(maskImage, maskImage->GetLargestPossibleRegion());
    PixelType                               maxValue = itk::NumericTraits<PixelType>::min();
    PixelType                               minValue = itk::NumericTraits<PixelType>::max();
    for (ItM.GoToBegin(), ItI.GoToBegin(); !ItI.IsAtEnd(); ++ItM, ++ItI)
    {
      if (ItM.Get() == maskLabel)
      {
        if (ItI.Get() < minValue)
        {
          minValue = ItI.Get();
        }
        else if (ItI.Get() > maxValue)
        {
          maxValue = ItI.Get();
        }
      }
    }

    using StatsType = itk::LabelStatisticsImageFilter<ImageType, MaskImageType>;
    typename StatsType::Pointer stats = StatsType::New();
    stats->SetInput(input);
    stats->SetLabelInput(maskImage);
    stats->UseHistogramsOn();
    stats->SetHistogramParameters(numberOfBins, minValue, maxValue);
    stats->Update();

    using OtsuType = itk::OtsuMultipleThresholdsCalculator<typename StatsType::HistogramType>;
    typename OtsuType::Pointer otsu = OtsuType::New();
    otsu->SetInputHistogram(stats->GetHistogram(maskLabel));
    otsu->SetNumberOfThresholds(NumberOfThresholds);
    otsu->Compute();

    typename OtsuType::OutputType thresholds = otsu->GetOutput();

    typename ImageType::Pointer output = ImageType::New();
    output->CopyInformation(maskImage);
    output->SetRegions(maskImage->GetLargestPossibleRegion());
    output->AllocateInitialized();

    itk::ImageRegionIterator<ImageType> ItO(output, output->GetLargestPossibleRegion());
    for (unsigned int i = 0; i < thresholds.size(); i++)
    {

      ItI.GoToBegin();
      ItM.GoToBegin();
      ItO.GoToBegin();
      while (!ItM.IsAtEnd())
      {
        if (ItM.Get() == maskLabel)
        {
          if (itk::Math::FloatAlmostEqual(ItO.Get(), itk::NumericTraits<typename ImageType::PixelType>::ZeroValue()) &&
              ItI.Get() < static_cast<typename ImageType::PixelType>(thresholds[i]))
          {
            ItO.Set(i + 1);
          }
        }
        ++ItI;
        ++ItM;
        ++ItO;
      }
    }

    ItI.GoToBegin();
    ItM.GoToBegin();
    ItO.GoToBegin();
    while (!ItM.IsAtEnd())
    {
      if (itk::Math::FloatAlmostEqual(ItO.Get(), itk::NumericTraits<typename ImageType::PixelType>::ZeroValue()) &&
          ItM.Get() == maskLabel)
      {
        ItO.Set(thresholds.size() + 1);
      }
      ++ItI;
      ++ItM;
      ++ItO;
    }
    return output;
  }
}

template <typename TImage, typename TMaskImage>
typename TImage::Pointer
KmeansThreshold(int NumberOfThresholds, typename TImage::Pointer input, typename TMaskImage::Pointer maskImage)
{
  std::cout << " Kmeans with " << NumberOfThresholds << " thresholds" << std::endl;

  using ImageType = TImage;
  using LabelImageType = TImage;
  using MaskImageType = TMaskImage;
  using RealType = float;
  using LabelType = int;

  using MeasurementVectorType = itk::Array<RealType>;
  using SampleType = typename itk::Statistics::ListSample<MeasurementVectorType>;

  int maskLabel = 1;
  if (maskImage.IsNull())
  {
    maskImage = AllocImage<MaskImageType>(input, maskLabel);
  }

  unsigned int                     numberOfTissueClasses = NumberOfThresholds + 1;
  typename LabelImageType::Pointer output = AllocImage<LabelImageType>(input, 0);

  using StatsType = itk::LabelStatisticsImageFilter<ImageType, MaskImageType>;
  typename StatsType::Pointer stats = StatsType::New();
  stats->SetInput(input);
  stats->SetLabelInput(maskImage);
  stats->UseHistogramsOff();
  stats->Update();

  RealType minValue = stats->GetMinimum(maskLabel);
  RealType maxValue = stats->GetMaximum(maskLabel);

  // The code below can be replaced by itkListSampleToImageFilter when we
  // migrate over to the Statistics classes current in the Review/ directory.
  //
  typename SampleType::Pointer sample = SampleType::New();
  sample->SetMeasurementVectorSize(1);

  itk::ImageRegionConstIteratorWithIndex<ImageType> ItI(input, input->GetRequestedRegion());
  for (ItI.GoToBegin(); !ItI.IsAtEnd(); ++ItI)
  {
    if (!maskImage || maskImage->GetPixel(ItI.GetIndex()) == maskLabel)
    {
      typename SampleType::MeasurementVectorType measurement;
      measurement.SetSize(1);
      measurement[0] = ItI.Get();
      sample->PushBack(measurement);
    }
  }

  using TreeGeneratorType = itk::Statistics::WeightedCentroidKdTreeGenerator<SampleType>;
  typename TreeGeneratorType::Pointer treeGenerator = TreeGeneratorType::New();
  treeGenerator->SetSample(sample);
  treeGenerator->SetBucketSize(16);
  treeGenerator->Update();

  using TreeType = typename TreeGeneratorType::KdTreeType;
  using EstimatorType = itk::Statistics::KdTreeBasedKmeansEstimator<TreeType>;
  typename EstimatorType::Pointer estimator = EstimatorType::New();
  estimator->SetKdTree(treeGenerator->GetOutput());
  estimator->SetMaximumIteration(200);
  estimator->SetCentroidPositionChangesThreshold(0.0);

  typename EstimatorType::ParametersType initialMeans(numberOfTissueClasses);

  for (unsigned int n = 0; n < numberOfTissueClasses; n++)
  {
    initialMeans[n] = static_cast<double>(minValue + (maxValue - minValue) * (static_cast<RealType>(n) + 0.5f) /
                                                       static_cast<RealType>(numberOfTissueClasses));
  }
  estimator->SetParameters(initialMeans);
  estimator->StartOptimization();

  //
  // Classify the samples
  //
  using DecisionRuleType = itk::Statistics::MinimumDecisionRule;
  typename DecisionRuleType::Pointer decisionRule = DecisionRuleType::New();

  using ClassifierType = itk::Statistics::SampleClassifierFilter<SampleType>;
  typename ClassifierType::Pointer classifier = ClassifierType::New();
  classifier->SetDecisionRule(decisionRule);
  classifier->SetInput(sample);
  classifier->SetNumberOfClasses(numberOfTissueClasses);

  typename ClassifierType::ClassLabelVectorObjectType::Pointer classLabels =
    ClassifierType::ClassLabelVectorObjectType::New();
  classifier->SetClassLabels(classLabels);
  typename ClassifierType::ClassLabelVectorType & classLabelVector = classLabels->Get();

  //
  // Order the cluster means so that the lowest mean of the input image
  // corresponds to label '1', the second lowest to label '2', etc.
  //
  std::vector<RealType> estimatorParameters;
  for (unsigned int n = 0; n < numberOfTissueClasses; n++)
  {
    estimatorParameters.push_back(estimator->GetParameters()[n]);
  }
  std::sort(estimatorParameters.begin(), estimatorParameters.end());

  using MembershipFunctionType = itk::Statistics::DistanceToCentroidMembershipFunction<MeasurementVectorType>;
  typename ClassifierType::MembershipFunctionVectorObjectType::Pointer membershipFunctions =
    ClassifierType::MembershipFunctionVectorObjectType::New();
  typename ClassifierType::MembershipFunctionVectorType & membershipFunctionsVector = membershipFunctions->Get();

  classifier->SetMembershipFunctions(membershipFunctions);
  for (unsigned int n = 0; n < numberOfTissueClasses; n++)
  {
    typename MembershipFunctionType::Pointer membershipFunction = MembershipFunctionType::New();
    membershipFunction->SetMeasurementVectorSize(sample->GetMeasurementVectorSize());
    typename MembershipFunctionType::CentroidType centroid;
    itk::NumericTraits<typename MembershipFunctionType::CentroidType>::SetLength(centroid,
                                                                                 sample->GetMeasurementVectorSize());
    centroid[0] = estimatorParameters[n];
    membershipFunction->SetCentroid(centroid);
    membershipFunctionsVector.push_back(membershipFunction.GetPointer());

    classLabelVector.push_back(static_cast<typename ClassifierType::ClassLabelType>(n + 1));
  }
  classifier->Update();

  //
  // Classify the voxels
  //
  using ClassifierOutputType = typename ClassifierType::MembershipSampleType;
  using LabelIterator = typename ClassifierOutputType::ConstIterator;

  itk::ImageRegionIteratorWithIndex<LabelImageType> ItO(output, output->GetRequestedRegion());
  ItO.GoToBegin();
  LabelIterator it = classifier->GetOutput()->Begin();
  while (it != classifier->GetOutput()->End())
  {
    if (!maskImage || maskImage->GetPixel(ItO.GetIndex()) == maskLabel)
    {
      ItO.Set(it.GetClassLabel());
      ++it;
    }
    else
    {
      ItO.Set(itk::NumericTraits<LabelType>::ZeroValue());
    }
    ++ItO;
  }

  return output;
}

template <unsigned int InImageDimension>
int
ThresholdImage(int argc, char * argv[])
{
  //  const     unsigned int   InImageDimension = AvantsImageDimension;
  using PixelType = float;
  using FixedImageType = itk::Image<PixelType, InImageDimension>;
  using LabelType = int;
  using MaskImageType = itk::Image<LabelType, InImageDimension>;

  typename FixedImageType::Pointer fixed;
  ReadImage<FixedImageType>(fixed, argv[2]);

  typename MaskImageType::Pointer maskImage = nullptr;
  if (argc > 6)
  {
    ReadImage<MaskImageType>(maskImage, argv[6]);
  }
  // Label the surface of the image
  typename FixedImageType::Pointer thresh;
  std::string                      threshtype = std::string(argv[4]);
  if (strcmp(threshtype.c_str(), "Otsu") == 0)
  {
    thresh = OtsuThreshold<FixedImageType, MaskImageType>(std::stoi(argv[5]), fixed, maskImage);
  }
  else if (strcmp(threshtype.c_str(), "Kmeans") == 0)
  {
    thresh = KmeansThreshold<FixedImageType, MaskImageType>(std::stoi(argv[5]), fixed, maskImage);
  }
  else
  {
    PixelType insideValue = 1;
    PixelType outsideValue = 0;
    if (argc > 6)
    {
      insideValue = static_cast<PixelType>(atof(argv[6]));
    }
    if (argc > 7)
    {
      outsideValue = static_cast<PixelType>(atof(argv[7]));
    }
    thresh = BinaryThreshold_AltInsideOutside_threashold<FixedImageType>(
      atof(argv[4]), atof(argv[5]), insideValue, outsideValue, fixed);
  }

  ANTs::WriteImage<FixedImageType>(thresh, argv[3]);
  return EXIT_SUCCESS;
}

// entry point for the library; parameter 'args' is equivalent to 'argv' in (argc,argv) of commandline parameters to
// 'main()'
int
ThresholdImage(std::vector<std::string> args, std::ostream * /*out_stream = nullptr */)
{
  // put the arguments coming in as 'args' into standard (argc,argv) format;
  // 'args' doesn't have the command name as first, argument, so add it manually;
  // 'args' may have adjacent arguments concatenated into one argument,
  // which the parser should handle
  args.insert(args.begin(), "ThresholdImage");

  int     argc = args.size();
  char ** argv = new char *[args.size() + 1];
  for (unsigned int i = 0; i < args.size(); ++i)
  {
    // allocate space for the string plus a null character
    argv[i] = new char[args[i].length() + 1];
    std::strncpy(argv[i], args[i].c_str(), args[i].length());
    // place the null character in the end
    argv[i][args[i].length()] = '\0';
  }
  argv[argc] = nullptr;
  // class to automatically cleanup argv upon destruction
  class Cleanup_argv
  {
  public:
    Cleanup_argv(char ** argv_, int argc_plus_one_)
      : argv(argv_)
      , argc_plus_one(argc_plus_one_)
    {}

    ~Cleanup_argv()
    {
      for (unsigned int i = 0; i < argc_plus_one; ++i)
      {
        delete[] argv[i];
      }
      delete[] argv;
    }

  private:
    char **      argv;
    unsigned int argc_plus_one;
  };
  Cleanup_argv cleanup_argv(argv, argc + 1);

  // antscout->set_stream( out_stream );

  if (argc < 3)
  {
    std::cout << "Usage: " << argv[0];
    std::cout << "   ImageDimension ImageIn.ext outImage.ext  threshlo threshhi <insideValue> <outsideValue>"
              << std::endl;
    std::cout << "   ImageDimension ImageIn.ext outImage.ext  Otsu NumberofThresholds <maskImage.ext>" << std::endl;
    std::cout << "   ImageDimension ImageIn.ext outImage.ext  Kmeans NumberofThresholds <maskImage.ext>" << std::endl;

    std::cout << " Inclusive thresholds " << std::endl;
    if (argc >= 2 && (std::string(argv[1]) == std::string("--help") || std::string(argv[1]) == std::string("-h")))
    {
      return EXIT_SUCCESS;
    }
    return EXIT_FAILURE;
  }

  // Get the image dimension

  switch (std::stoi(argv[1]))
  {
    case 2:
    {
      return ThresholdImage<2>(argc, argv);
    }
    break;
    case 3:
    {
      return ThresholdImage<3>(argc, argv);
    }
    break;
    case 4:
    {
      return ThresholdImage<4>(argc, argv);
    }
    break;
    default:
      std::cout << "Unsupported dimension" << std::endl;
      return EXIT_FAILURE;
  }

  return EXIT_SUCCESS;
}
} // namespace ants