1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412
|
// =============================================================== //
// //
// File : NT_tree_cmp.cxx //
// Purpose : //
// //
// Institute of Microbiology (Technical University Munich) //
// http://www.arb-home.de/ //
// //
// =============================================================== //
#include "NT_species_set.h"
#include "NT_local.h"
#include <aw_msg.hxx>
#include <arb_progress.h>
#include <string>
#include <climits>
using namespace std;
AWT_species_set_root::AWT_species_set_root(GBDATA *gb_maini, long nspeciesi, arb_progress *progress_) {
memset((char *)this, 0, sizeof(*this));
gb_main = gb_maini;
nspecies = nspeciesi;
progress = progress_;
sets = (AWT_species_set **)GB_calloc(sizeof(AWT_species_set *), (size_t)leafs_2_nodes(nspecies, ROOTED));
for (int i=0; i<256; i++) {
int j = i;
int count = 0;
while (j) { // count bits
if (j&1) count ++;
j = j>>1;
}
diff_bits[i] = count;
}
species_hash = GBS_create_hash(nspecies, GB_IGNORE_CASE);
species_counter = 1;
}
AWT_species_set_root::~AWT_species_set_root() {
for (int i=0; i<nsets; i++) delete sets[i];
free(sets);
GBS_free_hash(species_hash);
}
void AWT_species_set_root::add(const char *species_name) {
if (GBS_read_hash(species_hash, species_name)) {
aw_message(GBS_global_string("Warning: Species '%s' is found more than once in tree", species_name));
}
else {
GBS_write_hash(species_hash, species_name, species_counter++);
}
}
void AWT_species_set_root::add(AWT_species_set *set) {
nt_assert(nsets<nspecies*2);
sets[nsets++] = set;
}
AWT_species_set *AWT_species_set_root::search_best_match(const AWT_species_set *set, long& best_cost) {
// returns best match for 'set'
// sets 'best_cost' to minimum mismatches
AWT_species_set *result = 0;
best_cost = LONG_MAX;
unsigned char *sbs = set->bitstring;
for (long i=nsets-1; i>=0; i--) {
long sum = 0;
unsigned char *rsb = sets[i]->bitstring;
for (long j=bitstring_bytes()-1; j>=0; j--) {
sum += diff_bits[ sbs[j] ^ rsb[j] ];
}
if (sum > nspecies/2) sum = nspecies - sum; // take always the minimum
if (sum < best_cost) {
best_cost = sum;
result = sets[i];
}
}
return result;
}
int AWT_species_set_root::search_and_remember_best_match_and_log_errors(const AWT_species_set *set, FILE *log_file) {
// set's best_cost & best_node (of best match for 'set' found in other tree)
// returns the number of mismatches (plus a small penalty for missing species)
//
// When moving node info, 'set' represents a subtree of the source tree.
// When comparing topologies, 'set' represents a subtree of the destination tree.
long net_cost;
AWT_species_set *bs = search_best_match(set, net_cost);
double best_cost = net_cost + set->unfound_species_count * 0.0001;
if (best_cost < bs->best_cost) {
bs->best_cost = best_cost;
bs->best_node = set->node;
}
if (log_file) {
if (net_cost) {
fprintf(log_file, "Group '%s' not placed optimal (%li errors)\n",
set->node->name,
net_cost);
}
}
return net_cost;
}
void AWT_species_set::init(AP_tree *nodei, const AWT_species_set_root *ssr) {
memset((char *)this, 0, sizeof(*this));
bitstring = (unsigned char *)GB_calloc(sizeof(char), ssr->bitstring_longs()*sizeof(long));
this->node = nodei;
best_cost = 0x7fffffff;
}
AWT_species_set::AWT_species_set(AP_tree *nodei, const AWT_species_set_root *ssr, const char *species_name) {
init(nodei, ssr);
long species_index = GBS_read_hash(ssr->species_hash, species_name);
if (species_index) {
bitstring[species_index/8] |= 1 << (species_index % 8);
}
else {
unfound_species_count = 1;
}
}
AWT_species_set::AWT_species_set(AP_tree *nodei, const AWT_species_set_root *ssr, const AWT_species_set *l, const AWT_species_set *r) {
init(nodei, ssr);
const long *lbits = (const long *)l->bitstring;
const long *rbits = (const long *)r->bitstring;
long *dest = (long *)bitstring;
for (long j = ssr->bitstring_longs()-1; j>=0; j--) {
dest[j] = lbits[j] | rbits[j];
}
unfound_species_count = l->unfound_species_count + r->unfound_species_count;
}
AWT_species_set::~AWT_species_set() {
free(bitstring);
}
AWT_species_set *AWT_species_set_root::move_tree_2_ssr(AP_tree *node) {
AWT_species_set *ss;
// Warning: confusing resource handling:
// - leafs are returned "NOT owned by anybody"
// - inner nodes are added to and owned by this->sets
if (node->is_leaf) {
this->add(node->name);
ss = new AWT_species_set(node, this, node->name);
nt_assert(ss->is_leaf_set());
}
else {
AWT_species_set *ls = move_tree_2_ssr(node->get_leftson());
AWT_species_set *rs = move_tree_2_ssr(node->get_rightson());
ss = new AWT_species_set(node, this, ls, rs);
this->add(ss);
nt_assert(!ss->is_leaf_set());
if (ls->is_leaf_set()) delete ls;
if (rs->is_leaf_set()) delete rs;
}
return ss;
}
AWT_species_set *AWT_species_set_root::find_best_matches_info(AP_tree *node, FILE *log, bool compare_node_info) {
/* Go through all node of the source tree and search for the best
* matching node in dest_tree (meaning searching ssr->sets)
* If a match is found, set ssr->sets to this match.
*/
AWT_species_set *ss = NULL;
if (node->is_leaf) {
ss = new AWT_species_set(node, this, node->name);
}
else {
AWT_species_set *ls = find_best_matches_info(node->get_leftson(), log, compare_node_info);
AWT_species_set *rs = ls ? find_best_matches_info(node->get_rightson(), log, compare_node_info) : NULL;
if (rs) {
ss = new AWT_species_set(node, this, ls, rs);
if (compare_node_info) {
int mismatches = search_and_remember_best_match_and_log_errors(ss, log);
// the #-sign is important (otherwise TREE_write_Newick will not work correctly; interference with bootstrap values!)
char *new_remark = mismatches ? GBS_global_string_copy("# %i", mismatches) : NULL;
node->use_as_remark(new_remark);
}
else {
if (node->name) {
search_and_remember_best_match_and_log_errors(ss, log);
}
}
}
delete rs;
delete ls;
}
if (ss) {
progress->inc();
if (progress->aborted()) {
delete ss;
ss = NULL;
}
}
return ss;
}
GB_ERROR AWT_species_set_root::copy_node_information(FILE *log, bool delete_old_nodes, bool nodes_with_marked_only) {
GB_ERROR error = NULL;
if (log) fputs("\nDetailed group changes:\n\n", log);
for (long j=this->nsets-1; j>=0 && !error; j--) {
AWT_species_set *cset = this->sets[j];
char *old_group_name = NULL;
bool insert_new_node = cset->best_node && cset->best_node->name;
if (nodes_with_marked_only && insert_new_node) {
if (!cset->node->contains_marked_species()) insert_new_node = false;
}
if (cset->node->gb_node && (delete_old_nodes || insert_new_node)) { // There is already a node, delete old
if (cset->node->name == 0) {
GBDATA *gb_name = GB_entry(cset->node->gb_node, "group_name");
if (gb_name) {
cset->node->name = GB_read_string(gb_name);
}
else {
cset->node->name = strdup("<gb_node w/o name>");
}
}
old_group_name = strdup(cset->node->name); // store old_group_name to rename new inserted node
error = GB_delete(cset->node->gb_node);
if (!error) {
cset->node->gb_node = 0;
freenull(cset->node->name);
}
}
if (!error) {
if (insert_new_node) {
cset->node->gb_node = GB_create_container(cset->node->get_tree_root()->get_gb_tree(), "node");
error = GB_copy(cset->node->gb_node, cset->best_node->gb_node);
if (!error) {
GBDATA *gb_name = GB_entry(cset->node->gb_node, "group_name");
nt_assert(gb_name);
if (gb_name) {
char *best_group_name = GB_read_string(gb_name);
if (old_group_name) {
if (!delete_old_nodes) {
if (strcmp(old_group_name, best_group_name) != 0) { // old and new name differ
char *new_group_name = GBS_global_string_copy("%s [was: %s]", best_group_name, old_group_name);
GB_write_string(gb_name, new_group_name);
if (log) fprintf(log, "Destination group '%s' overwritten by '%s'\n", old_group_name, new_group_name);
free(new_group_name);
}
else {
if (log) fprintf(log, "Group '%s' remains unchanged\n", old_group_name);
}
}
else {
if (log) {
if (strcmp(old_group_name, best_group_name) == 0) {
fprintf(log, "Group '%s' remains unchanged\n", old_group_name);
}
else {
fprintf(log, "Destination group '%s' overwritten by '%s'\n", old_group_name, best_group_name);
}
}
}
}
else {
if (log) fprintf(log, "Group '%s' inserted\n", best_group_name);
}
free(best_group_name);
}
}
}
else {
if (old_group_name && log) fprintf(log, "Destination group '%s' removed\n", old_group_name);
}
}
free(old_group_name);
}
return error;
}
void AWT_species_set_root::finish(GB_ERROR& error) {
if (!error) error = progress->error_if_aborted();
progress->done();
}
GB_ERROR AWT_move_info(GBDATA *gb_main, const char *tree_source, const char *tree_dest, const char *log_file, TreeInfoMode mode, bool nodes_with_marked_only) {
GB_ERROR error = 0;
FILE *log = 0;
nt_assert(contradicted(mode == TREE_INFO_COMPARE, log_file));
if (mode == TREE_INFO_COMPARE) {
// info is written into 'tree_source'
// (but we want to modify destination tree - like 'mode node info' does)
std::swap(tree_source, tree_dest);
}
if (log_file) {
nt_assert(mode == TREE_INFO_COPY || mode == TREE_INFO_ADD);
log = fopen(log_file, "w");
fprintf(log,
"LOGFILE: %s node info\n"
"\n"
" Source tree '%s'\n"
"Destination tree '%s'\n"
"\n",
mode == TREE_INFO_COPY ? "Copying" : "Adding",
tree_source, tree_dest);
}
GB_begin_transaction(gb_main);
AP_tree_root rsource(new AliView(gb_main), new AP_TreeNodeFactory, NULL, false);
AP_tree_root rdest (new AliView(gb_main), new AP_TreeNodeFactory, NULL, false);
AP_tree_root& rsave = (mode == TREE_INFO_COMPARE) ? rsource : rdest;
arb_progress progress("Comparing Topologies");
error = rsource.loadFromDB(tree_source);
if (!error) error = rsource.linkToDB(0, 0);
if (!error) {
error = rdest.loadFromDB(tree_dest);
if (!error) error = rdest.linkToDB(0, 0);
if (!error) {
AP_tree *source = rsource.get_root_node();
AP_tree *dest = rdest.get_root_node();
long nspecies = dest->count_leafs();
long source_leafs = source->count_leafs();
long source_nodes = leafs_2_nodes(source_leafs, ROOTED);
arb_progress compare_progress(source_nodes);
compare_progress.subtitle("Comparing both trees");
AWT_species_set_root *ssr = new AWT_species_set_root(gb_main, nspecies, &compare_progress);
ssr->move_tree_2_ssr(dest);
if (source_leafs < 3) error = GB_export_error("Destination tree has less than 3 species");
else {
AWT_species_set *root_setl = ssr->find_best_matches_info(source->get_leftson(), log, mode == TREE_INFO_COMPARE);
AWT_species_set *root_setr = root_setl ? ssr->find_best_matches_info(source->get_rightson(), log, mode == TREE_INFO_COMPARE) : NULL;
if (root_setr) {
if (mode != TREE_INFO_COMPARE) {
compare_progress.subtitle("Copying node information");
ssr->copy_node_information(log, mode == TREE_INFO_COPY, nodes_with_marked_only);
}
long dummy = 0;
AWT_species_set *new_root_setl = ssr->search_best_match(root_setl, dummy);
AWT_species_set *new_root_setr = ssr->search_best_match(root_setr, dummy);
AP_tree *new_rootl = new_root_setl->node;
AP_tree *new_rootr = new_root_setr->node;
new_rootl->set_root(); // set root correctly
new_rootr->set_root(); // set root correctly
compare_progress.subtitle("Saving trees");
AP_tree *saved_root = (mode == TREE_INFO_COMPARE) ? source : new_rootr->get_root_node();
error = GBT_overwrite_tree(rsave.get_gb_tree(), saved_root);
if (!error) {
char *entry;
if (mode == TREE_INFO_COMPARE) {
entry = GBS_global_string_copy("Compared topology with %s", tree_dest);
}
else {
const char *copiedOrAdded = mode == TREE_INFO_COPY ? "Copied" : "Added";
entry = GBS_global_string_copy("%s node info %sfrom %s",
copiedOrAdded,
nodes_with_marked_only ? "of marked " : "",
tree_source);
}
GBT_log_to_tree_remark(rsave.get_gb_tree(), entry);
free(entry);
}
}
delete root_setl;
delete root_setr;
}
ssr->finish(error);
delete ssr;
}
}
if (log) {
if (error) fprintf(log, "\nError: %s\n", error); // write error to log as well
fclose(log);
}
return GB_end_transaction(gb_main, error);
}
|