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// ================================================================ //
// //
// File : DI_foundclusters.cxx //
// Purpose : Store results of cluster detection //
// //
// Coded by Ralf Westram (coder@reallysoft.de) in November 2009 //
// Institute of Microbiology (Technical University Munich) //
// http://www.arb-home.de/ //
// //
// ================================================================ //
#include "di_foundclusters.hxx"
#include "di_clustertree.hxx"
#include <aw_window.hxx>
#include <aw_select.hxx>
#include <cmath>
using namespace std;
ID Cluster::unused_id = 1;
static AP_FLOAT calc_mean_dist_to(const ClusterTree *distance_to, const LeafRelations *distances) {
size_t count = 0;
AP_FLOAT sum = 0.0;
LeafRelationCIter dist_end = distances->end();
for (LeafRelationCIter dist = distances->begin(); dist != dist_end; ++dist) {
const TwoLeafs& leafs = dist->first;
if (leafs.first() == distance_to || leafs.second() == distance_to) {
count++;
sum += dist->second;
}
}
cl_assert(count); // 'distance_to' does not occur in 'distances'
return sum/count;
}
Cluster::Cluster(ClusterTree *ct)
: next_desc(NULL)
{
cl_assert(ct->get_state() == CS_IS_CLUSTER);
id = unused_id++;
const LeafRelations *distances = ct->get_sequence_dists();
cl_assert(distances);
LeafRelationCIter dist = distances->begin();
LeafRelationCIter dist_end = distances->end();
cl_assert(dist != dist_end); // oops - empty cluster
min_dist = max_dist = dist->second;
mean_dist = 0.0;
AP_FLOAT min_mean_dist = 9999999999.0;
representative = NULL;
for (; dist != dist_end; ++dist) {
const TwoLeafs& leafs = dist->first;
AP_FLOAT di = dist->second;
if (di<min_dist) min_dist = di;
if (di>max_dist) max_dist = di;
mean_dist += di;
for (int i = 0; i<2; ++i) {
const ClusterTree *member = i ? leafs.first() : leafs.second();
GBDATA *gb_species = member->gb_node;
cl_assert(gb_species);
if (members.find(gb_species) == members.end()) { // not in set
members.insert(gb_species);
AP_FLOAT mean_dist_to_member = calc_mean_dist_to(member, distances);
if (mean_dist_to_member<min_mean_dist) {
representative = gb_species;
min_mean_dist = mean_dist_to_member;
}
}
}
}
cl_assert(members.size() == ct->get_leaf_count());
min_bases = ct->get_min_bases();
{
ClusterTree *root = ct->get_root_node();
size_t allSize = root->get_leaf_count();
size_t size = ct->get_leaf_count();
size_t first = ct->relative_position_in(root);
size_t last = first+size-1;
rel_tree_pos = ((double(first)+last)/2) / allSize;
}
mean_dist /= distances->size();
cl_assert(representative);
desc = create_description(ct);
}
static string *get_downgroups(const ARB_countedTree *ct, const ARB_tree_predicate& keep_group_name, size_t& group_members) {
string *result = NULL;
if (ct->is_leaf) {
group_members = 0;
}
else {
const char *group_name = ct->get_group_name();
if (group_name && keep_group_name.selects(*ct)) {
group_members = ct->get_leaf_count();
result = new string(ct->name);
}
else {
string *leftgroups = get_downgroups(ct->get_leftson(), keep_group_name, group_members);
size_t right_members;
string *rightgroups = get_downgroups(ct->get_rightson(), keep_group_name, right_members);
group_members += right_members;
if (leftgroups || rightgroups) {
if (!leftgroups) { result = rightgroups; rightgroups = NULL; }
else if (!rightgroups) { result = leftgroups; leftgroups = NULL; }
else result = new string(*leftgroups+"+"+*rightgroups);
delete leftgroups;
delete rightgroups;
}
}
}
return result;
}
static const char *get_upgroup(const ARB_countedTree *ct, const ARB_tree_predicate& keep_group_name, const ARB_countedTree*& upgroupPtr, bool reuse_original_name) {
const char *group_name = ct->get_group_name();
char *original = (reuse_original_name && group_name) ? originalGroupName(group_name) : NULL;
if (original) {
static SmartCharPtr result;
result = original;
group_name = &*result;
upgroupPtr = ct;
}
else if (group_name && keep_group_name.selects(*ct)) {
upgroupPtr = ct;
}
else {
const ARB_countedTree *father = ct->get_father();
if (father) {
group_name = get_upgroup(father, keep_group_name, upgroupPtr, reuse_original_name);
}
else {
upgroupPtr = ct;
group_name = "WHOLE_TREE";
}
}
cl_assert(!upgroupPtr || ct->is_inside(upgroupPtr));
cl_assert(group_name);
return group_name;
}
string Cluster::create_description(const ARB_countedTree *ct) {
// creates cluster description (using up- and down-groups, percentages, existing groups, ...)
cl_assert(!ct->is_leaf);
string name;
UseAnyTree use_any_upgroup;
const ARB_countedTree *upgroup = NULL;
const char *upgroup_name = get_upgroup(ct, use_any_upgroup, upgroup, false);
size_t upgroup_members = upgroup->get_leaf_count();
size_t cluster_members = ct->get_leaf_count();
cl_assert(upgroup_members>0); // if no group, whole tree should have been returned
if (upgroup_members == cluster_members) { // use original or existing name
name = string("[G] ")+upgroup_name;
}
else {
size_t downgroup_members;
string *downgroup_names = get_downgroups(ct, use_any_upgroup, downgroup_members);
AP_FLOAT up_rel = (AP_FLOAT)cluster_members/upgroup_members; // used for: xx% of upgroup (big is good)
AP_FLOAT down_rel = (AP_FLOAT)downgroup_members/cluster_members; // used for: downgroup(s) + (1-xx)% outgroup (big is good)
if (up_rel>down_rel) { // prefer up_percent
name = string(GBS_global_string("%4.1f%% of %s", up_rel*100.0, upgroup_name));
}
else {
if (downgroup_members == cluster_members) {
name = downgroup_names->c_str();
}
else {
name = string(GBS_global_string("%s + %4.1f%% outgroup", downgroup_names->c_str(), (1-down_rel)*100.0));
}
}
delete downgroup_names;
}
return name;
}
string Cluster::get_upgroup_info(const ARB_countedTree *ct, const ARB_tree_predicate& keep_group_name) {
// generates a string indicating relative position in up-group
cl_assert(!ct->is_leaf);
const ARB_countedTree *upgroup = NULL;
const char *upgroup_name = get_upgroup(ct, keep_group_name, upgroup, true);
size_t upgroup_members = upgroup->get_leaf_count();
size_t cluster_members = ct->get_leaf_count();
const char *upgroup_info;
if (upgroup_members == cluster_members) {
upgroup_info = upgroup_name;
}
else {
size_t cluster_pos1 = ct->relative_position_in(upgroup)+1; // range [1..upgroup_members]
size_t cluster_posN = cluster_pos1+cluster_members-1;
upgroup_info = GBS_global_string("%zu-%zu/%zu_%s", cluster_pos1, cluster_posN, upgroup_members, upgroup_name);
}
return upgroup_info;
}
// --------------------------
// DisplayFormat
class DisplayFormat : virtual Noncopyable {
size_t max_count;
AP_FLOAT max_dist;
AP_FLOAT max_minBases;
mutable char *format_string;
static long calc_digits(long val) {
long digits;
if (val>0) digits = log10(val)+1;
else if (val<0) digits = calc_digits(-val);
else digits = 1;
cl_assert(digits>0);
return digits;
}
static char *make_format(size_t val) {
long digits = calc_digits(val);
return GBS_global_string_copy("%%%lizu", digits);
}
static char *make_format(AP_FLOAT val) {
long digits = calc_digits(long(val));
long afterdot = digits <=3 ? 5-digits-1 : 0;
cl_assert(afterdot >= 0);
long all = digits+(afterdot ? (afterdot+1) : 0);
return GBS_global_string_copy("%%%li.%lif", all, afterdot);
}
public:
DisplayFormat()
: max_count(0)
, max_dist(0.0)
, max_minBases(0.0)
, format_string(NULL)
{}
~DisplayFormat() {
free(format_string);
}
void announce(size_t count, AP_FLOAT maxDist, AP_FLOAT minBases) {
max_count = std::max(max_count, count);
max_dist = std::max(max_dist, maxDist);
max_minBases = std::max(max_minBases, minBases);
freenull(format_string);
}
const char *get_format() const {
if (!format_string) {
// create format string for description
char *count_part = make_format(max_count);
char *dist_part = make_format(max_dist);
char *bases_part = make_format(max_minBases);
format_string = GBS_global_string_copy("%s %s [%s-%s] %s %%s",
count_part,
dist_part, dist_part, dist_part,
bases_part);
free(bases_part);
free(dist_part);
free(count_part);
}
return format_string;
}
};
void Cluster::scan_display_widths(DisplayFormat& format) const {
AP_FLOAT max_of_all_dists = std::max(max_dist, std::max(min_dist, mean_dist));
format.announce(get_member_count(), max_of_all_dists*100.0, min_bases);
}
const char *Cluster::get_list_display(const DisplayFormat *format) const {
const char *format_string;
if (format) format_string = format->get_format();
else format_string = "%zu %.3f [%.3f-%.3f] %.1f %s";
return GBS_global_string(format_string,
get_member_count(),
mean_dist*100.0,
min_dist*100.0,
max_dist*100.0,
min_bases,
desc.c_str());
}
// ---------------------
// ClustersData
void ClustersData::add(ClusterPtr clus, ClusterSubset subset) {
known_clusters[clus->get_ID()] = clus;
get_subset(subset).push_back(clus->get_ID());
}
void ClustersData::remove(ClusterPtr clus, ClusterSubset subset) {
int pos = get_pos(clus, subset);
if (pos != -1) {
ClusterIDs& ids = get_subset(subset);
ClusterIDs::iterator toRemove = ids.begin();
advance(toRemove, pos);
ids.erase(toRemove);
known_clusters.erase(clus->get_ID());
}
}
void ClustersData::clear(ClusterSubset subset) {
ClusterIDs& ids = get_subset(subset);
ClusterIDsIter id_end = ids.end();
for (ClusterIDsIter id = ids.begin(); id != id_end; ++id) {
known_clusters.erase(*id);
}
ids.clear();
}
void ClustersData::store(ID id) {
ClusterPtr toStore = clusterWithID(id);
remove(toStore, SHOWN_CLUSTERS);
add(toStore, STORED_CLUSTERS);
}
void ClustersData::store_all() {
copy(shown.begin(), shown.end(), back_insert_iterator<ClusterIDs>(stored));
shown.clear();
sort_needed = false;
}
void ClustersData::restore_all() {
copy(stored.begin(), stored.end(), back_insert_iterator<ClusterIDs>(shown));
stored.clear();
sort_needed = true;
}
void ClustersData::swap_all() {
swap(stored, shown);
sort_needed = true;
}
class SortClusterIDsBy {
const KnownClusters& known;
ClusterOrder primary_order;
ClusterOrder secondary_order;
public:
SortClusterIDsBy(const KnownClusters& known_, ClusterOrder primary, ClusterOrder secondary)
: known(known_)
, primary_order(primary)
, secondary_order(secondary)
{}
bool operator()(ID id1, ID id2) const {
ClusterPtr cl1 = known.find(id1)->second;
ClusterPtr cl2 = known.find(id2)->second;
cl_assert(!cl1.isNull() && !cl2.isNull());
bool less = cl1->lessByOrder(*cl2, primary_order);
if (!less) {
bool equal = !cl2->lessByOrder(*cl1, primary_order);
if (equal) {
less = cl1->lessByOrder(*cl2, secondary_order);
}
}
return less;
}
};
void ClustersData::update_cluster_selection_list() {
cl_assert(clusterList);
clusterList->clear();
if (shown.empty()) {
clusterList->insert_default("<No clusters detected>", ID(0));
}
else {
{
SortClusterIDsBy sortBy(known_clusters, criteria[0], criteria[1]);
sort(shown.begin(), shown.end(), sortBy);
}
{
ClusterIDsIter cl_end = shown.end();
DisplayFormat format;
for (int pass = 1; pass <= 2; ++pass) {
for (ClusterIDsIter cl = shown.begin(); cl != cl_end; ++cl) {
ID id = *cl;
ClusterPtr cluster = clusterWithID(id);
if (pass == 1) {
cluster->scan_display_widths(format);
}
else {
clusterList->insert(cluster->get_list_display(&format), cluster->get_ID());
}
}
}
clusterList->insert_default("<select no cluster>", ID(0));
}
}
clusterList->update();
}
void ClustersData::free() {
// delete calculated/stored data
shown.clear();
stored.clear();
update_cluster_selection_list();
known_clusters.clear();
}
char *originalGroupName(const char *groupname) {
char *original = NULL;
const char *was = strstr(groupname, " {was:");
const char *closing = strchr(groupname, '}');
if (was && closing) {
original = GB_strpartdup(was+6, closing-1);
if (original[0]) {
char *sub = originalGroupName(original);
if (sub) freeset(original, sub);
}
else {
freenull(original); // empty -> invalid
}
}
return original;
}
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