File: ps_detect_weak_differences.cxx

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// =============================================================== //
//                                                                 //
//   File      : ps_detect_weak_differences.cxx                    //
//   Purpose   :                                                   //
//                                                                 //
//   Coded by Wolfram Foerster in October 2002                     //
//   Institute of Microbiology (Technical University Munich)       //
//   http://www.arb-home.de/                                       //
//                                                                 //
// =============================================================== //

#include "ps_database.hxx"
#include "ps_bitmap.hxx"
#include "ps_tools.hxx"

#include <climits>
#include <sys/times.h>

// common globals
static SpeciesID          __MAX_ID;
static SpeciesID          __MIN_ID;
static PS_BitMap_Fast    *__MAP;
// globals for PS_detect_weak_differences
static IDVector          *__PATH;
static IDVector          *__INVERSE_PATH;
static unsigned long int  __COUNT_SET_OPS  = 0;
static unsigned long int  __COUNT_SET_OPS2 = 0;
static char              *__NODES_LEFT;
// globals for PS_print_and_evaluate_map
static IDSet             *__PATHSET;
static IDID2IDSetMap     *__PAIR2PATH;
static SpeciesID          __ONEMATCH_MIN_ID;
static SpeciesID          __ONEMATCH_MAX_ID;

#if defined(DEBUG)
void PS_debug_print_path() {
    printf("__PATH %3zu :", __PATH->size());
    int c = 1;
    for (IDVectorCIter i = __PATH->begin(); i != __PATH->end(); ++i, ++c) {
        if (c % 20 == 0) printf("\n");
        printf(" %3i", *i);
    }
    printf("\n");
}

void PS_debug_print_inverse_path() {
    printf("__INVERSE_PATH %3zu :", __INVERSE_PATH->size());
    int c = 1;
    for (IDVectorCIter i = __INVERSE_PATH->begin(); i != __INVERSE_PATH->end(); ++i, ++c) {
        if (c % 20 == 0) printf("\n");
        printf(" %3i", *i);
    }
    printf("\n");
}
#endif

static void PS_detect_weak_differences_stepdown(const PS_NodePtr& _ps_node,
                                                const SpeciesID  _parent_ID,
                                                const long       _depth) {
    //  Recursively walk through tree and make a bool-matrix of SpeciesID's
    //  where true means that the 2 species can be distinguished by a probe.
    //
    //  The first occurrence of a pair of distinguishable IDs is stored as (smaller_ID,bigger_ID).
    //  The following occurrence of this pair are stored as (bigger_ID,smaller_ID).
    //  (this allows us to find pairs of SpeciesIDs that can be distinguished by exactly one probe)

    SpeciesID id = _ps_node->getNum();
    if (_depth < 60) {
        printf("%s", __NODES_LEFT);
        for (int i = 0; i < 60; ++i) printf("\b");
        fflush(stdout);
    }
    //
    // append IDs to paths
    //
    __PATH->push_back(id);                                                                      // append id to path
    for (SpeciesID i = (_parent_ID < __MIN_ID) ? __MIN_ID : _parent_ID+1; i < id; ++i) {        // append parent_id+1 .. id-1 to inverse path
        __INVERSE_PATH->push_back(i);
    }

    //
    // set values in the maps if node has probes
    //
    if (_ps_node->hasProbes()) {
        if (_ps_node->hasPositiveProbes() && _ps_node->hasInverseProbes()) {
            unsigned long int set_ops = 2*__PATH->size()*(__MAX_ID-id-1+__INVERSE_PATH->size());
            if (ULONG_MAX - __COUNT_SET_OPS < set_ops) {
                set_ops = set_ops - (ULONG_MAX - __COUNT_SET_OPS);
                __COUNT_SET_OPS = 0;
                ++__COUNT_SET_OPS2;
            }
            __COUNT_SET_OPS = __COUNT_SET_OPS + set_ops;

            SpeciesID inverse_path_ID;
            // path loop
            for (IDVectorCIter it_path = __PATH->begin();
                 it_path != __PATH->end();
                 ++it_path) {
                SpeciesID path_ID = *it_path;
                // inverse path loop (explicit)
                for (IDVectorCIter it_inverse_path = __INVERSE_PATH->begin();
                     it_inverse_path != __INVERSE_PATH->end();
                     ++it_inverse_path) {
                    inverse_path_ID = *it_inverse_path;

                    __MAP->setTrue(path_ID, inverse_path_ID);
                    __MAP->setTrue(inverse_path_ID, path_ID);
                }

                // inverse path loop (implicit)
                for (inverse_path_ID = id+1; inverse_path_ID < __MAX_ID; ++inverse_path_ID) { // skip to id ABOVE current node id
                    __MAP->setTrue(path_ID, inverse_path_ID);
                    __MAP->setTrue(inverse_path_ID, path_ID);
                }
            }
        }
        else {
            unsigned long int set_ops = __PATH->size()*(__MAX_ID-id-1+__INVERSE_PATH->size());
            if (ULONG_MAX - __COUNT_SET_OPS < set_ops) {
                set_ops = set_ops - (ULONG_MAX - __COUNT_SET_OPS);
                __COUNT_SET_OPS = 0;
                ++__COUNT_SET_OPS2;
            }
            __COUNT_SET_OPS = __COUNT_SET_OPS + set_ops;

            SpeciesID inverse_path_ID;
            SpeciesID smaller_ID;
            SpeciesID bigger_ID;
            // path loop
            for (IDVectorCIter it_path = __PATH->begin();
                 it_path != __PATH->end();
                 ++it_path) {
                SpeciesID path_ID = *it_path;
                // inverse path loop (explicit)
                for (IDVectorCIter it_inverse_path = __INVERSE_PATH->begin();
                     it_inverse_path != __INVERSE_PATH->end();
                     ++it_inverse_path) {
                    inverse_path_ID = *it_inverse_path;
                    smaller_ID = (path_ID < inverse_path_ID) ? path_ID : inverse_path_ID;
                    bigger_ID  = (path_ID > inverse_path_ID) ? path_ID : inverse_path_ID;

                    if (__MAP->get(smaller_ID, bigger_ID)) {
                        __MAP->setTrue(bigger_ID, smaller_ID);
                    }
                    else {
                        __MAP->setTrue(smaller_ID, bigger_ID);
                    }
                }

                // inverse path loop (implicit)
                for (inverse_path_ID = id+1; inverse_path_ID < __MAX_ID; ++inverse_path_ID) { // skip to id ABOVE current node id
                    smaller_ID = (path_ID < inverse_path_ID) ? path_ID : inverse_path_ID;
                    bigger_ID  = (path_ID > inverse_path_ID) ? path_ID : inverse_path_ID;

                    if (__MAP->get(smaller_ID, bigger_ID)) {
                        __MAP->setTrue(bigger_ID, smaller_ID);
                    }
                    else {
                        __MAP->setTrue(smaller_ID, bigger_ID);
                    }
                }
            }
        }
    }
    //
    // step down the children
    //
    int c = _ps_node->countChildren()-1;
    for (PS_NodeMapConstIterator i = _ps_node->getChildrenBegin();
          i != _ps_node->getChildrenEnd();
          ++i, --c) {
        if (_depth < 60) {
            if (c < 10) {
                __NODES_LEFT[_depth] = '0'+c;
            }
            else {
                __NODES_LEFT[_depth] = '+';
            }
        }
        PS_detect_weak_differences_stepdown(i->second, id, _depth+1);
    }
    if (_depth < 60) __NODES_LEFT[_depth] = ' ';

    //
    // remove IDs from paths
    //
    __PATH->pop_back();
    while ((__INVERSE_PATH->back() > _parent_ID) && (!__INVERSE_PATH->empty())) {
        __INVERSE_PATH->pop_back();
    }
}

static void PS_detect_weak_differences(const PS_NodePtr& _root_node) {
    //
    // make bitmap
    //
    __PATH         = new IDVector;
    __INVERSE_PATH = new IDVector;

    int c = 0;
    struct tms before;
    times(&before);
    struct tms before_first_level_node;
    for (PS_NodeMapConstIterator i = _root_node->getChildrenBegin(); i != _root_node->getChildrenEnd(); ++i, ++c) {
        if (_root_node->countChildren()-c-1 < 10) {
            __NODES_LEFT[0] = '0'+_root_node->countChildren()-c-1;
        }
        else {
            __NODES_LEFT[0] = '+';
        }
        if ((c < 50) || (c % 100 == 0)) {
            times(&before_first_level_node);
            printf("PS_detect_weak_differences_stepdown( %i ) : %i. of %zu  ", i->first, c+1, _root_node->countChildren()); fflush(stdout);
        }
        PS_detect_weak_differences_stepdown(i->second, -1, 1);
        if ((c < 50) || (c % 100 == 0)) {
            PS_print_time_diff(&before_first_level_node, "this node ", "  ");
            PS_print_time_diff(&before, "total ", "\n");
        }
    }
    printf("%lu * %lu + %lu set operations performed\n", __COUNT_SET_OPS2, ULONG_MAX, __COUNT_SET_OPS); fflush(stdout);

    delete __PATH;
    delete __INVERSE_PATH;
}

typedef map<ID2IDPair, PS_NodePtr>    IDID2NodeMap;
typedef IDID2NodeMap::iterator       IDID2NodeMapIter;
typedef IDID2NodeMap::const_iterator IDID2NodeMapCIter;

void PS_find_probes_for_pairs(const PS_NodePtr& _ps_node, ID2IDSet &_pairs) {
    SpeciesID id         = _ps_node->getNum();
    bool      has_probes = _ps_node->hasProbes();

    //
    // append ID to path
    //
    __PATHSET->insert(id);

    //
    // don't look at path until ID is greater than lowest ID in the set of ID-pairs
    //
    if ((id >= __ONEMATCH_MIN_ID) && has_probes) {
        for (ID2IDSetCIter pair=_pairs.begin(); pair != _pairs.end(); ++pair) {
            // look for pair-IDs in the path
            bool found_first  = __PATHSET->find(pair->first) != __PATHSET->end();
            bool found_second = __PATHSET->find(pair->second) != __PATHSET->end();
            if (found_first ^ found_second) { // ^ is XOR
                printf("found path for (%i,%i) at %p ", pair->first, pair->second, &(*_ps_node));
                _ps_node->printOnlyMe();
                (*__PAIR2PATH)[*pair] = *__PATHSET;     // store path
                
                bool scanMinMax = (pair->first == __ONEMATCH_MIN_ID) || (pair->second == __ONEMATCH_MAX_ID);
                _pairs.erase(pair);                     // remove found pair
                if (scanMinMax) {
                    // scan pairs for new min,max IDs
                    __ONEMATCH_MIN_ID = __MAX_ID;
                    __ONEMATCH_MAX_ID = -1;
                    for (ID2IDSetCIter p=_pairs.begin(); p != _pairs.end(); ++p) {
                        if (p->first  < __ONEMATCH_MIN_ID) __ONEMATCH_MIN_ID = p->first;
                        if (p->second > __ONEMATCH_MAX_ID) __ONEMATCH_MAX_ID = p->second;
                    }
                    printf(" new MIN,MAX (%d,%d)", __ONEMATCH_MIN_ID, __ONEMATCH_MAX_ID);
                }
                printf("\n");
            }
        }
    }

    //
    // step down the children unless all paths are found
    // if either ID is lower than highest ID in the set of ID-pairs
    // or the node has no probes
    //
    if ((id < __ONEMATCH_MAX_ID) || (! has_probes)) {
        for (PS_NodeMapConstIterator i = _ps_node->getChildrenBegin();
             (i != _ps_node->getChildrenEnd()) && (!_pairs.empty());
             ++i) {
            PS_find_probes_for_pairs(i->second, _pairs);
        }
    }

    //
    // remove ID from path
    //
    __PATHSET->erase(id);
}

static void PS_print_and_evaluate_map(const PS_NodePtr& _root_node, const char *_result_filename) {
    //
    // print and evaluate bitmap
    //
    printf("\n\n----------------- bitmap ---------------\n\n");
    SpeciesID smaller_id;
    SpeciesID bigger_id;
    ID2IDSet  noMatch;
    ID2IDSet  oneMatch;
    bool      bit1;
    bool      bit2;
    __ONEMATCH_MIN_ID = __MAX_ID;
    __ONEMATCH_MAX_ID = __MIN_ID;
    for (SpeciesID id1 = __MIN_ID; id1 <= __MAX_ID; ++id1) {
        for (SpeciesID id2 = __MIN_ID; id2 <= id1; ++id2) {
            smaller_id = (id1 < id2) ? id1 : id2;
            bigger_id  = (id1 < id2) ? id2 : id1;
            bit1       = __MAP->get(smaller_id, bigger_id);
            bit2       = __MAP->get(bigger_id, smaller_id);
            if (bit1 && bit2) {
            }
            else if (bit1) {
                oneMatch.insert(ID2IDPair(smaller_id, bigger_id));
                if (smaller_id < __ONEMATCH_MIN_ID) __ONEMATCH_MIN_ID = smaller_id;
                if (bigger_id  > __ONEMATCH_MAX_ID) __ONEMATCH_MAX_ID = bigger_id;
            }
            else {
                if (id1 != id2) noMatch.insert(ID2IDPair(smaller_id, bigger_id));  // there are no probes to distinguish a species from itself .. obviously
            }
        }
    }
    printf("(enter to continue)\n");

    printf("\n\n----------------- no matches ---------------\n\n");
    if (!_result_filename) {
        for (ID2IDSetCIter i = noMatch.begin(); i != noMatch.end(); ++i) {
            printf("%6i %6i\n", i->first, i->second);
        }
    }
    printf("%zu no matches\n(enter to continue)\n", noMatch.size());

    printf("\n\n----------------- one match ---------------\n\n");
    if (!_result_filename) {
        for (ID2IDSetCIter i = oneMatch.begin(); i != oneMatch.end(); ++i) {
            printf("%6i %6i\n", i->first, i->second);
        }
    }
    printf("%zu one matches\n(enter to continue)\n", oneMatch.size());
    //
    // find paths for pairs
    //
    __PATHSET   = new IDSet;
    __PAIR2PATH = new IDID2IDSetMap;
    int c = 0;
    for (PS_NodeMapConstIterator i = _root_node->getChildrenBegin();
         (i != _root_node->getChildrenEnd()) && (!oneMatch.empty());
         ++i, ++c) {
        if ((c < 50) || (c % 100 == 0)) printf("PS_find_probes_for_pairs( %i ) : %i of %zu\n", i->first, c+1, _root_node->countChildren());
        PS_find_probes_for_pairs(i->second, oneMatch);
    }
    //
    // print paths
    //
    for (IDID2IDSetMapCIter i = __PAIR2PATH->begin();
         i != __PAIR2PATH->end();
         ++i) {
        printf("\nPair (%i,%i) Setsize (%zu)", i->first.first, i->first.second, i->second.size());
        PS_NodePtr current_node = _root_node;
        long c2 = 0;
        for (IDSetCIter path_id=i->second.begin();
             path_id != i->second.end();
             ++path_id, ++c2) {
            current_node = current_node->getChild(*path_id).second;
            if (c2 % 10 == 0) printf("\n");
            printf("%6i%s ", *path_id, (current_node->hasProbes()) ? ((current_node->hasInverseProbes()) ? "*" : "+") : "-");
        }
        printf("\nFinal Node : %p ", &(*current_node));
        current_node->printOnlyMe();
        printf("\n");
    }
    printf("\n%zu paths\n", __PAIR2PATH->size());
    //
    // oups
    //
    if (!oneMatch.empty()) {
        printf("did not find a path for these :\n");
        for (ID2IDSetCIter i = oneMatch.begin(); i != oneMatch.end(); ++i) {
            printf("%6i %6i\n", i->first, i->second);
        }
    }
    //
    // make preset map
    //
    PS_BitMap_Counted *preset = new PS_BitMap_Counted(false, __MAX_ID+1);
    // set bits for no matches
    for (ID2IDSetCIter pair=noMatch.begin(); pair != noMatch.end(); ++pair) {
        preset->setTrue(pair->second, pair->first);
    }
    // iterate over paths
    for (IDID2IDSetMapCIter i = __PAIR2PATH->begin();
         i != __PAIR2PATH->end();
         ++i) {
        // iterate over all IDs except path
        IDSetCIter path_iter    = i->second.begin();
        SpeciesID  next_path_id = *path_iter;
        for (SpeciesID id = __MIN_ID; id <= __MAX_ID; ++id) {
            if (id == next_path_id) {   // if i run into a ID in path
                ++path_iter;            // advance to next path ID
                next_path_id = (path_iter == i->second.end()) ? -1 : *path_iter;
                continue;               // skip this ID
            }
            // iterate over path IDs
            for (IDSetCIter path_id = i->second.begin(); path_id != i->second.end(); ++path_id) {
                if (id == *path_id) continue;   // obviously a probe cant differ a species from itself
                if (id > *path_id) {
                    preset->setTrue(id, *path_id);
                }
                else {
                    preset->setTrue(*path_id, id);
                }
            }
        }
    }
    preset->recalcCounters();
    if (!_result_filename) preset->print();
    //
    // save results
    //
    if (_result_filename) {
        PS_FileBuffer *result_file = new PS_FileBuffer(_result_filename, PS_FileBuffer::WRITEONLY);
        // no matches
        printf("saving no matches to %s...\n", _result_filename);
        result_file->put_long(noMatch.size());
        for (ID2IDSetCIter i = noMatch.begin(); i != noMatch.end(); ++i) {
            result_file->put_int(i->first);
            result_file->put_int(i->second);
        }
        // one matches
        printf("saving one matches to %s...\n", _result_filename);
        result_file->put_long(__PAIR2PATH->size());
        for (IDID2IDSetMapCIter i = __PAIR2PATH->begin(); i != __PAIR2PATH->end(); ++i) {
            result_file->put_int(i->first.first);
            result_file->put_int(i->first.second);
            result_file->put_long(i->second.size());
            for (IDSetCIter path_id=i->second.begin(); path_id != i->second.end(); ++path_id) {
                result_file->put_int(*path_id);
            }
        }
        // preset bitmap
        printf("saving preset bitmap to %s...\n", _result_filename);
        preset->save(result_file);
        delete result_file;
    }
    delete preset;
    delete __PATHSET;
    delete __PAIR2PATH;
}

//  ====================================================
//  ====================================================

int main(int argc,   char *argv[]) {

   // open probe-set-database
    if (argc < 2) {
        printf("Missing argument\n Usage %s <database name> [[-]bitmap filename] [+result filename]\n ", argv[0]);
        printf("if bitmap filename begins with '-' it is loaded, else its created\n ");
        printf("result filename MUST be preceded by '+'\n");
        exit(1);
    }

    const char *input_DB_name   = argv[1];
    const char *bitmap_filename = 0;
    const char *result_filename = 0;

    if (argc > 2) {
        if (argv[2][0] == '+') {
            result_filename = argv[2]+1;
        }
        else {
            bitmap_filename = argv[2];
        }
    }
    if (argc > 3) {
        if (argv[3][0] == '+') {
            result_filename = argv[3]+1;
        }
        else {
            bitmap_filename = argv[3];
        }
    }

    struct tms before;
    times(&before);
    printf("Opening probe-set-database '%s'..\n", input_DB_name);
    PS_Database *db = new PS_Database(input_DB_name, PS_Database::READONLY);
    db->load();
    __MAX_ID = db->getMaxID();
    __MIN_ID = db->getMinID();
    PS_print_time_diff(&before, "(enter to continue)  ");

    __MAP = new PS_BitMap_Fast(false, __MAX_ID+1);
    if (!bitmap_filename || (bitmap_filename[0] != '-')) {
        printf("detecting..\n"); fflush(stdout);
        __NODES_LEFT = (char*)malloc(61);
        memset(__NODES_LEFT, ' ', 60);
        __NODES_LEFT[60] = '\x00';
        PS_detect_weak_differences(db->getRootNode());
        free(__NODES_LEFT);
        if (bitmap_filename) {
            printf("saving bitmap to file %s\n", bitmap_filename);
            PS_FileBuffer *mapfile = new PS_FileBuffer(bitmap_filename, PS_FileBuffer::WRITEONLY);
            __MAP->save(mapfile);
            delete mapfile;
        }
    }
    else if (bitmap_filename) {
        printf("loading bitmap from file %s\n", bitmap_filename+1);
        PS_FileBuffer *mapfile = new PS_FileBuffer(bitmap_filename+1, PS_FileBuffer::READONLY);
        __MAP->load(mapfile);
        delete mapfile;
    }
    printf("(enter to continue)\n");

    times(&before);
    PS_print_and_evaluate_map(db->getRootNode(), result_filename);
    PS_print_time_diff(&before, "(enter to continue)  ");
    delete __MAP;

    printf("removing database from memory\n");
    delete db;
    printf("(enter to continue)\n");

    return 0;
}