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|
gc; GPCRSECRETIN
gx; PR00249
gn; COMPOUND(7)
ga; 27-JUL-1992; UPDATE 19-JUN-1999
gt; Secretin-like GPCR superfamily signature
gp; PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
gp; PRINTS; PR00250 GPCRSTE2; PR00899 GPCRSTE3; PR00251 BACTRLOPSIN
gp; PRINTS; PR01694 BAIPRECURSOR; PR01350 CTRFAMILY; PR01278 CD97PROTEIN
gp; PRINTS; PR01279 CRFRECEPTOR; PR01127 DIUHORMONER; PR01128 EMR1HORMONER
gp; PRINTS; PR01352 GHRHRECEPTOR; PR01129 GIPRECEPTOR; PR01353 GLUCAGNFAMLY
gp; PRINTS; PR01695 IGHEPTARCPTR; PR01444 LATROPHILIN; PR00393 PTRHORMONER
gp; PRINTS; PR00490 SECRETINR; PR00491 VASOACTVEIPR; PR01422 GPR56ORPHANR
gp; INTERPRO; IPR000832
gp; PROSITE; PS00649 G_PROTEIN_RECEP_F2_1; PS00650 G_PROTEIN_RECEP_F2_2
gp; PFAM; PF00002 7tm_2
bb;
gr; 1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
gr; Fingerprinting G protein-coupled receptors.
gr; PROTEIN ENG. 7(2) 195-203 (1994).
gr;
gr; 2. ISHIHARA T., NAKAMURA S., KAZIRO, Y., TAKAHASHI, T., TAKAHASHI, K.
gr; AND NAGATA, S.
gr; Molecular cloning and expression of a cDNA encoding the secretin receptor
gr; EMBO J. 10 1635-1641 (1991).
gr;
gr; 3. LIN, H.Y., HARRIS, T.L., FLANNERY, M.S., ARUFFO, A., KAJI, E.H.,
gr; GORN, A., KOLAKOWSKI, L.F., LODISH, H.F. AND GOLDRING, S.R.
gr; Expression cloning of adenylate cyclase-coupled calcitonin receptor
gr; SCIENCE 254 1022-1024 (1991).
gr;
gr; 4. JUEPPNER, H., ABOU-SAMRA, A.-B., FREEMAN, M., KONG, X.F.,
gr; SCHIPANI, E., RICHARDS, J., KOLALOWSKI, L.F., HOCK, J., POTTS, J.T.,
gr; KRONENBERG, H.M. AND SEGRE, G.E.
gr; A G protein linked receptor for parathyroid hormone and parathyroid
gr; hormone-related peptide.
gr; SCIENCE 254 1024-1026 (1991).
gr;
gr; 5. ISHIHARA, T., SHIGEMOTO, R., MORI, K., TAKAHASHI, K. AND NAGATA, S.
gr; Functional expression and tissue distribution of a novel receptor for
gr; vasoactive intestinal polypeptide.
gr; NEURON 8(4) 811-819 (1992).
bb;
bb;
gd; G protein-coupled receptors (GPCRs) constitute a vast protein family that
gd; encompasses a wide range of functions (including various autocrine, para-
gd; crine and endocrine processes). They show considerable diversity at the
gd; sequence level, on the basis of which they can be separated into distinct
gd; groups. We use the term clan to describe the GPCRs, as they embrace a group
gd; of families for which there are indications of evolutionary relationship,
gd; but between which there is no statistically significant similarity in
gd; sequence [1]. The currently known clan members include the rhodopsin-like
gd; GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
gd; pheromone receptors, and the metabotropic glutamate receptor family.
gd;
gd; The secretin-like GPCRs include secretin [2], calcitonin [3], parathyroid
gd; hormone/parathyroid hormone-related peptides [4] and vasoactive intestinal
gd; peptide [5], all of which activate adenylyl cyclase and the phosphatidyl-
gd; inositol-calcium pathway. The amino acid sequences of the receptors contain
gd; high proportions of hydrophobic residues grouped into 7 domains, in a
gd; manner reminiscent of the rhodopsins and other receptors believed to inter-
gd; act with G proteins. However, while a similar 3D framework has been
gd; proposed to account for this, there is no significant sequence similarity
gd; between these families: the secretin-like receptors thus bear their own
gd; unique '7TM' signature.
gd;
gd; GPCRSECRETIN is a 7-element fingerprint that provides a signature for the
gd; secretin-like GPCR superfamily. The fingerprint was derived from an initial
gd; alignment of 4 sequences: the motifs encode the 7 hydrophobic, membrane-
gd; spanning regions (cf. PROSITE pattern PS00650 G_PROTEIN_RECEP_F2_2). A
gd; single iteration on OWL17.0 was required to reach convergence, no further
gd; sequences being identified beyond the starting set.
gd;
gd; An update on SPTR37_9f identified a true set of 59 sequences, and 15
gd; partial matches.
bb;
bb;
si; SUMMARY INFORMATION
si; -------------------
sd; 59 codes involving 7 elements
sd; 0 codes involving 6 elements
sd; 1 codes involving 5 elements
sd; 2 codes involving 4 elements
sd; 1 codes involving 3 elements
sd; 11 codes involving 2 elements
bb;
bb;
ci; COMPOSITE FINGERPRINT INDEX
ci; ---------------------------
cr;
cd; 7| 59 59 59 59 59 59 59
cd; 6| 0 0 0 0 0 0 0
cd; 5| 1 0 1 1 1 0 1
cd; 4| 0 1 2 2 2 1 0
cd; 3| 1 0 1 0 1 0 0
cd; 2| 8 0 10 3 0 0 1
cd; --+------------------------------------
cd; | 1 2 3 4 5 6 7
bb;
bb;
tp; VIPR_RAT SCRC_RAT SCRC_HUMAN PACR_RAT
tp; PACR_MOUSE PACR_HUMAN O73769 PACR_BOVIN
tp; SCRC_RABIT VIPR_HUMAN VIPR_PIG VIPS_HUMAN
tp; PTRR_HUMAN PTRR_DIDMA PTRR_PIG VIPR_CARAU
tp; VIPS_MOUSE VIPS_RAT PTRR_MOUSE PTRR_RAT
tp; O73768 GIPR_RAT GIPR_HUMAN GIPR_MESAU
tp; GLR_RAT GLPR_RAT GLR_MOUSE GLPR_MOUSE
tp; GLR_HUMAN GLPR_HUMAN CRFR_MOUSE CRFR_SHEEP
tp; CRFR_HUMAN CRFR_RAT CRFR_XENLA CRF2_RAT
tp; PTR2_HUMAN GRFR_PIG Q99431 O43461
tp; CRF2_HUMAN GRFR_HUMAN PTH2_RAT GRFR_RAT
tp; CRF2_MOUSE GRFR_MOUSE CRFR_CHICK CRF2_XENLA
tp; CALR_CAVPO CALR_HUMAN CALR_RABIT CALR_RAT
tp; CALR_MOUSE CALR_PIG DIHR_MANSE CGRR_HUMAN
tp; CGRR_RAT DIHR_ACHDO Q93245
bb;
sn; Codes involving 5 elements
st; YQ44_CAEEL
bb;
sn; Codes involving 4 elements
st; Q98955 YOW3_CAEEL
bb;
sn; Codes involving 3 elements
st; EMR1_HUMAN
bb;
sn; Codes involving 2 elements
st; Q10922 EMR1_MOUSE O88929 O88928
st; O88927 O88926 O88925 O88924
st; CD97_HUMAN O00718
bb;
bb;
tt; VIPR_RAT VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 PRECURSOR (VIP-R-1) (PITUITARY ADEN
tt; SCRC_RAT SECRETIN RECEPTOR PRECURSOR (SCT-R) - RATTUS NORVEGICUS (RAT).
tt; SCRC_HUMAN SECRETIN RECEPTOR PRECURSOR (SCT-R) - HOMO SAPIENS (HUMAN).
tt; PACR_RAT PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE IA RECEPTOR PRECURSOR (P
tt; PACR_MOUSE PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RECEPTOR PRECURSOR (PA
tt; PACR_HUMAN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RECEPTOR PRECURSOR (PA
tt; O73769 PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE 1 RECEPTOR PRECURSOR - C
tt; PACR_BOVIN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RECEPTOR PRECURSOR (PA
tt; SCRC_RABIT SECRETIN RECEPTOR PRECURSOR (SCT-R) - ORYCTOLAGUS CUNICULUS (RABBIT).
tt; VIPR_HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 PRECURSOR (VIP-R-1) (PITUITARY ADEN
tt; VIPR_PIG VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 PRECURSOR (VIP-R-1) (PITUITARY ADEN
tt; VIPS_HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 PRECURSOR (VIP-R-2) (PITUITARY ADEN
tt; PTRR_HUMAN PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR PRECURSOR (PTH/
tt; PTRR_DIDMA PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR PRECURSOR (PTH/
tt; PTRR_PIG PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR PRECURSOR (PTH/
tt; VIPR_CARAU VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR (VIP-R) (VIP RECEPTOR) - CARASSIUS AU
tt; VIPS_MOUSE VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 PRECURSOR (VIP-R-2) (PITUITARY ADEN
tt; VIPS_RAT VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 PRECURSOR (VIP-R-2) (PITUITARY ADEN
tt; PTRR_MOUSE PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR PRECURSOR (PTH/
tt; PTRR_RAT PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR PRECURSOR (PTH/
tt; O73768 GROWTH-HORMONE RELEASING HORMONE-LIKE PEPTIDE RECEPTOR - CARASSIUS AURATUS (GOLD
tt; GIPR_RAT GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (GLUCOSE- DEPENDENT IN
tt; GIPR_HUMAN GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (GLUCOSE- DEPENDENT IN
tt; GIPR_MESAU GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (GLUCOSE- DEPENDENT IN
tt; GLR_RAT GLUCAGON RECEPTOR PRECURSOR (GL-R) - RATTUS NORVEGICUS (RAT).
tt; GLPR_RAT GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR) (GLP-1-R) - RATTUS N
tt; GLR_MOUSE GLUCAGON RECEPTOR PRECURSOR (GL-R) - MUS MUSCULUS (MOUSE).
tt; GLPR_MOUSE GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR) (GLP-1-R) - MUS MUSC
tt; GLR_HUMAN GLUCAGON RECEPTOR PRECURSOR (GL-R) - HOMO SAPIENS (HUMAN).
tt; GLPR_HUMAN GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR) (GLP-1-R) - HOMO SAP
tt; CRFR_MOUSE CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - MUS MUSCULU
tt; CRFR_SHEEP CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - OVIS ARIES
tt; CRFR_HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - HOMO SAPIEN
tt; CRFR_RAT CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - RATTUS NORV
tt; CRFR_XENLA CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - XENOPUS LAE
tt; CRF2_RAT CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) - RATTUS NORV
tt; PTR2_HUMAN PARATHYROID HORMONE RECEPTOR PRECURSOR (PTH2 RECEPTOR) - HOMO SAPIENS (HUMAN).
tt; GRFR_PIG GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RECEPTOR) (GRF RECEPTO
tt; Q99431 CORTICOTROPIN RELEASING HORMONE RECEPTOR TYPE 2 BETA ISOFORM (CRF2 RECEPTOR, BET
tt; O43461 CORTICOTROPIN RELEASING HORMONE RECEPTOR TYPE 2 GAMMA ISOFORM - HOMO SAPIENS (HU
tt; CRF2_HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) - HOMO SAPIEN
tt; GRFR_HUMAN GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RECEPTOR) (GRF RECEPTO
tt; PTH2_RAT PARATHYROID HORMONE RECEPTOR PRECURSOR (PTH2 RECEPTOR) - RATTUS NORVEGICUS (RAT)
tt; GRFR_RAT GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RECEPTOR) (GRF RECEPTO
tt; CRF2_MOUSE CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) (CRF-RB) (CRH
tt; GRFR_MOUSE GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RECEPTOR) (GRF RECEPTO
tt; CRFR_CHICK CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R) (CRF1) - GALLUS GALL
tt; CRF2_XENLA CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R) (CRF2) - XENOPUS LAE
tt; CALR_CAVPO CALCITONIN RECEPTOR PRECURSOR (CT-R) - CAVIA PORCELLUS (GUINEA PIG).
tt; CALR_HUMAN CALCITONIN RECEPTOR PRECURSOR (CT-R) - HOMO SAPIENS (HUMAN).
tt; CALR_RABIT CALCITONIN RECEPTOR PRECURSOR (CT-R) - ORYCTOLAGUS CUNICULUS (RABBIT).
tt; CALR_RAT CALCITONIN RECEPTOR PRECURSOR (CT-R) (C1A/C1B) - RATTUS NORVEGICUS (RAT).
tt; CALR_MOUSE CALCITONIN RECEPTOR PRECURSOR (CT-R) - MUS MUSCULUS (MOUSE).
tt; CALR_PIG CALCITONIN RECEPTOR PRECURSOR (CT-R) - SUS SCROFA (PIG).
tt; DIHR_MANSE DIURETIC HORMONE RECEPTOR (DH-R) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HOR
tt; CGRR_HUMAN CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR PRECURSOR (CGRP TYPE 1 RECEPTOR)
tt; CGRR_RAT CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR PRECURSOR (CGRP TYPE 1 RECEPTOR)
tt; DIHR_ACHDO DIURETIC HORMONE RECEPTOR PRECURSOR (DH-R) - ACHETA DOMESTICUS (HOUSE CRICKET).
tt; Q93245 C18B12B.1.
tt;
tt; YQ44_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR C13B9.4 IN CHROMOSOME III - CAENORHABDITIS E
tt;
tt; Q98955 GLUCAGON RECEPTOR - MELEAGRIS GALLOPAVO (COMMON TURKEY).
tt; YOW3_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR ZK643.3 - CAENORHABDITIS ELEGANS.
tt;
tt; EMR1_HUMAN CELL SURFACE GLYCOPROTEIN EMR1 PRECURSOR (EMR1 HORMONE RECEPTOR) - HOMO SAPIENS
tt;
tt; Q10922 HYPOTHETICAL 174.3 KD PROTEIN B0286.2 IN CHROMOSOME II - CAENORHABDITIS ELEGANS.
tt; EMR1_MOUSE CELL SURFACE GLYCOPROTEIN EMR1 PRECURSOR (EMR1 HORMONE RECEPTOR) (CELL SURFACE G
tt; O88929 CL3BC - RATTUS NORVEGICUS (RAT).
tt; O88928 CL3BB - RATTUS NORVEGICUS (RAT).
tt; O88927 CL3BA - RATTUS NORVEGICUS (RAT).
tt; O88926 CL3AC - RATTUS NORVEGICUS (RAT).
tt; O88925 CL3AB - RATTUS NORVEGICUS (RAT).
tt; O88924 CL3AA - RATTUS NORVEGICUS (RAT).
tt; CD97_HUMAN LEUCOCYTE ANTIGEN CD97 PRECURSOR - HOMO SAPIENS (HUMAN).
tt; O00718 CD97 - HOMO SAPIENS (HUMAN).
bb;
bb;
sh; SCAN HISTORY
sh; ------------
dn; OWL17_0 1 50 NSINGLE
dn; OWL18_0 1 50 NSINGLE
dn; OWL19_1 1 50 NSINGLE
dn; OWL20_1 1 50 NSINGLE
dn; OWL21_1 1 100 NSINGLE
dn; OWL23_2 2 100 NSINGLE
dn; OWL28_0 1 200 NSINGLE
dn; SPTR37_9f 3 80 NSINGLE
bb;
bb;
im; INITIAL MOTIF-SETS
im; ------------------
ic; GPCRSECRETIN1
il; 25
it; Secretin motif I - 1
id; MIYTVGYSMSLASLTVAVLILAYFR PTRR_RAT 189 189
id; MIYTVGYSISLGSLTVAVLILGYFR PTRR_DIDMA 186 186
id; VMYTVGYSSSLAMLLVALSILCSFR SCRC_RAT 144 144
id; YLAIVGHSLSIFTLVISLGIFVFFR CALR_HUMAN 150 150
bb;
ic; GPCRSECRETIN2
il; 25
it; Secretin motif II - 1
id; YIHMHMFLSFMLRAASIFVKDAVLY PTRR_RAT 221 7
id; YIHMHLFVSFMLRAVSIFIKDAVLY PTRR_DIDMA 218 7
id; YIHMHLFVSFILRALSNFIKDAVLF SCRC_RAT 176 7
id; TLHKNMFLTYILNSMIIIIHLVEVV CALR_HUMAN 198 23
bb;
ic; GPCRSECRETIN3
il; 24
it; Secretin motif III - 1
id; VAVTFFLYFLATNYYWILVEGLYL PTRR_RAT 283 37
id; VAVTVFLYFLTTNYYWILVEGLYL PTRR_DIDMA 277 34
id; LVMIFFQYCIMANYAWLLVEGLYL SCRC_RAT 217 16
id; ILHFFHQYMMACNYFWMLCEGIYL CALR_HUMAN 237 14
bb;
ic; GPCRSECRETIN4
il; 26
it; Secretin motif IV - 1
id; LWGFTIFGWGLPAVFVAVWVGVRATL PTRR_RAT 321 14
id; LWGFTLFGWGLPAVFVAVWVTVRATL PTRR_DIDMA 315 14
id; LQAFVLLGWGSPAIFVALWAITRHFL SCRC_RAT 255 14
id; LRWYYLLGWGFPLVPTTIHAITRAVY CALR_HUMAN 275 14
bb;
ic; GPCRSECRETIN5
il; 26
it; Secretin motif V - 1
id; WIIQVPILASVVLNFILFINIIRVLA PTRR_RAT 361 14
id; WIIQVPILAAIVVNFILFINIIRVLA PTRR_DIDMA 355 14
id; WVIRGPVILSILINFIFFINILRILM SCRC_RAT 296 15
id; YIIHGPVMAALVVNFFFLLNIVRVLV CALR_HUMAN 315 14
bb;
ic; GPCRSECRETIN6
il; 21
it; Secretin motif VI - 1
id; LLRSTLVLVPLFGVHYTVFMA PTRR_RAT 406 19
id; LLKSTLVLMPLFGVHYIVFMA PTRR_DIDMA 400 19
id; LAKSTLLLIPLFGIHYIVFAF SCRC_RAT 340 18
id; AVKATMILVPLLGIQFVVFPW CALR_HUMAN 357 16
bb;
ic; GPCRSECRETIN7
il; 22
it; Secretin motif VII - 1
id; MHYEMLFNSFQGFFVAIIYCFC PTRR_RAT 441 14
id; MHYEMLFNSFQGFFVAIIYCFC PTRR_DIDMA 435 14
id; LFFELALGSFQGLVVAVLYCFL SCRC_RAT 370 9
id; DYVMHSLIHFQGFFVATIYCFC CALR_HUMAN 389 11
bb;
fm; FINAL MOTIF-SETS
fm; ----------------
fc; GPCRSECRETIN1
fl; 25
ft; Secretin motif I - 3
fd; TGYTIGYSLSLASLLVAMAILSLFR VIPR_RAT 145 145
fd; VMYTVGYSSSLAMLLVALSILCSFR SCRC_RAT 144 144
fd; VMYTVGYSSSLVMLLVALGILCAFR SCRC_HUMAN 144 144
fd; ALYTVGYSTSLATLTTAMVILCRFR PACR_RAT 154 154
fd; ALYTVGYSTSLVTLTTAMVILCRFR PACR_MOUSE 155 155
fd; ALYTVGYSTSLVTLTTAMVILCRFR PACR_HUMAN 155 155
fd; ALYTVGYSTSLVSLTTAMVILCRFR O73769 147 147
fd; ALYTVGYSTSLVTLTTAMVILCRFR PACR_BOVIN 172 172
fd; VMYTVGYSSSLVMLLVALGILCAFR SCRC_RABIT 140 140
fd; TGYTIGYGLSLATLLVATAILSLFR VIPR_HUMAN 144 144
fd; TGYTIGYSLSLAALLVATAILSLFR VIPR_PIG 145 145
fd; AIYTLGYSVSLMSLATGSIILCLFR VIPS_HUMAN 128 128
fd; MIYTVGYSVSLASLTVAVLILAYFR PTRR_HUMAN 189 189
fd; MIYTVGYSISLGSLTVAVLILGYFR PTRR_DIDMA 186 186
fd; MIYTVGYSVSLASLTVAVLILAYFR PTRR_PIG 185 185
fd; IGYTIGHSVSLISLTTAIVILCMSR VIPR_CARAU 105 105
fd; AIYTLGYSVSLMSLTTGSIIICLFR VIPS_MOUSE 127 127
fd; AIYTLGYSVSLMSLTTGSIIICLFR VIPS_RAT 127 127
fd; MIYTVGYSMSLASLTVAVLILAYFR PTRR_MOUSE 189 189
fd; MIYTVGYSMSLASLTVAVLILAYFR PTRR_RAT 189 189
fd; QLYTAGYATSLISLITAVIIFTCFR O73768 138 138
fd; VVYTVGYSLSLATLLLALLILSLFR GIPR_RAT 136 136
fd; VMYTVGYSLSLATLLLALLILSLFR GIPR_HUMAN 139 139
fd; VVYTVGYSLSLGTLLLALLILSLFR GIPR_MESAU 136 136
fd; VMYTVGYSLSLGALLLALVILLGLR GLR_RAT 144 144
fd; IIYTVGYALSFSALVIASAILVSFR GLPR_RAT 146 146
fd; VMYTVGYSLSLGALLLALVILLGLR GLR_MOUSE 144 144
fd; IIYTVGYALSFSALVIASAILVGFR GLPR_MOUSE 146 146
fd; VMYTVGYSLSLGALLLALAILGGLS GLR_HUMAN 143 143
fd; IIYTVGYALSFSALVIASAILLGFR GLPR_HUMAN 146 146
fd; IINYLGHCISLVALLVAFVLFLRLR CRFR_MOUSE 121 121
fd; IINYLGHCISLAALLVAFVLFLRLR CRFR_SHEEP 121 121
fd; IINYLGHCISLVALLVAFVLFLRLR CRFR_HUMAN 121 121
fd; IINYLGHCISLVALLVAFVLFLRLR CRFR_RAT 121 121
fd; VINFLGHSISLCALLVAFILFLRLR CRFR_XENLA 121 121
fd; IINYLGHCVSVVALVAAFLLFLVLR CRF2_RAT 118 118
fd; VMYTVGYSISFGSLAVAILIIGYFR PTR2_HUMAN 146 146
fd; IVYTTGHSVSAVALFVAIAILVALR GRFR_PIG 131 131
fd; VVNYLGHCVSVAALVAAFLLFLALR Q99431 145 145
fd; VVNYLGHCVSVAALVAAFLLFLALR O43461 104 104
fd; VVNYLGHCVSVAALVAAFLLFLALR CRF2_HUMAN 118 118
fd; IIYTVGHSISIVALFVAITILVALR GRFR_HUMAN 131 131
fd; ILYTVGYSISFGSLAVAILIIGYFR PTH2_RAT 144 144
fd; IIYTTGHSISIVALCVAIAILVALR GRFR_RAT 131 131
fd; IVNYLGHCVSVVALVAAFLLFLVLR CRF2_MOUSE 138 138
fd; IIYTTGHSISIVALCVAIAILVALR GRFR_MOUSE 131 131
fd; IINYLGHCVSLGTLLVAFVLFMRLR CRFR_CHICK 126 126
fd; IINYLGHCISILALVIAFLLFLCLR CRF2_XENLA 120 120
fd; YLAIVGHSMSIITLVVSLGIFVYFR CALR_CAVPO 150 150
fd; YLAIVGHSLSIFTLVISLGIFVFFR CALR_HUMAN 150 150
fd; YLAIVGHSLSIFTLVISLGIFKCFR CALR_RABIT 150 150
fd; YLALVGHSMSIAALIASMGIFLFFK CALR_RAT 150 150
fd; YLALVGHSLSIAALVASMLIFWIFK CALR_MOUSE 150 150
fd; YLAIVGHSLSILTLLISLGIFMFLR CALR_PIG 151 151
fd; LIYLAGYSLSLAVLSLAVFVFLYFK DIHR_MANSE 88 88
fd; YLTIIGHGLSIASLLISLGIFFYFK CGRR_HUMAN 143 143
fd; YLTIIGHGLSIASLIISLIIFFYFK CGRR_RAT 143 143
fd; FVFFVGFCLSLVAIAVAIWIFLYFK DIHR_ACHDO 135 135
fd; SVSLTLSFVSVILLVAAIVLFSIFD Q93245 40 40
bb;
fc; GPCRSECRETIN2
fl; 25
ft; Secretin motif II - 3
fd; YIHMHLFMSFILRATAVFIKDMALF VIPR_RAT 177 7
fd; YIHMHLFVSFILRALSNFIKDAVLF SCRC_RAT 176 7
fd; YIHMHLFVSFILRALSNFIKDAVLF SCRC_HUMAN 176 7
fd; FIHMNLFVSFMLRAISVFIKDWILY PACR_RAT 186 7
fd; FIHMNLFVSFMLRAISVFIKDWILY PACR_MOUSE 187 7
fd; FIHMNLFVSFMLRAISVFIKDWILY PACR_HUMAN 187 7
fd; FIHMNLFVSFMLRAISVFIKDGVLY O73769 179 7
fd; FIHMNLFVSFMLRAISVFIKDWILY PACR_BOVIN 204 7
fd; YIHMHLFLSFILRALSNFIKDAVLF SCRC_RABIT 172 7
fd; YIHMHLFISFILRAAAVFIKDLALF VIPR_HUMAN 176 7
fd; YIHMHLFISFILRATAVFIKDLALF VIPR_PIG 177 7
fd; YIHLNLFLSFILRAISVLVKDDVLY VIPS_HUMAN 160 7
fd; YIHMHLFLSFMLRAVSIFVKDAVLY PTRR_HUMAN 221 7
fd; YIHMHLFVSFMLRAVSIFIKDAVLY PTRR_DIDMA 218 7
fd; YIHMHLFLSFMLRAVSIFVKDAVLY PTRR_PIG 217 7
fd; YIHMHLFVSFILKAIAVFVKDAVLY VIPR_CARAU 137 7
fd; YIHLNLFLSFMLRAISVLVKDSVLY VIPS_MOUSE 159 7
fd; YIHLNLFLSFMLRAISVLVKDSVLY VIPS_RAT 159 7
fd; YIHMHMFLSFMLRAASIFVKDAVLY PTRR_MOUSE 221 7
fd; YIHMHMFLSFMLRAASIFVKDAVLY PTRR_RAT 221 7
fd; YIHINLFVSFILRATAVFIKDAVLF O73768 170 7
fd; YIHMNLFTSFMLRAGAILTRDQLLP GIPR_RAT 168 7
fd; YIHINLFTSFMLRAAAILSRDRLLP GIPR_HUMAN 171 7
fd; YIHMNVFLSFMLRAVAILTRDRLLP GIPR_MESAU 168 7
fd; YIHGNLFASFVLKAGSVLVIDWLLK GLR_RAT 176 7
fd; YIHLNLFASFILRALSVFIKDAALK GLPR_RAT 178 7
fd; YIHGNLFASFVLKAGSVLVIDWLLK GLR_MOUSE 176 7
fd; YIHLNLFASFILRALSVFIKDAALK GLPR_MOUSE 178 7
fd; AIHANLFASFVLKASSVLVIDGLLR GLR_HUMAN 175 7
fd; YIHLNLFASFILRALSVFIKDAALK GLPR_HUMAN 178 7
fd; IIHWNLISAFILRNATWFVVQLTVS CRFR_MOUSE 153 7
fd; IIHWNLISAFILRNATWFVVQLTMS CRFR_SHEEP 153 7
fd; IIHWNLISAFILRNATWFVVQLTMS CRFR_HUMAN 182 36
fd; IIHWNLISAFILRNATWFVVQLTVS CRFR_RAT 153 7
fd; IIHWNLITAFILRNVTWFVMQLTLS CRFR_XENLA 153 7
fd; VIHWNLITTFILRNITWFLLQLIDH CRF2_RAT 150 7
fd; YIHMHLFVSFMLRATSIFVKDRVVH PTR2_HUMAN 178 7
fd; YIHSQLFATFILKAGAVFLKDAALF GRFR_PIG 163 7
fd; VIHWNLITTFILRNVMWFLLQLVDH Q99431 177 7
fd; VIHWNLITTFILRNVMWFLLQLVDH O43461 136 7
fd; VIHWNLITTFILRNVMWFLLQLVDH CRF2_HUMAN 150 7
fd; YVHTQLFTTFILKAGAVFLKDAALF GRFR_HUMAN 163 7
fd; YIHLHLFVSFMLRAXSIFVKDRVAQ PTH2_RAT 176 7
fd; YIHTQLFATFILKASAVFLKDAAVF GRFR_RAT 163 7
fd; VIHWNLITTFILRNIAWFLLQLIDH CRF2_MOUSE 170 7
fd; YIHTQLFATFILKASAVFLKDAAIF GRFR_MOUSE 163 7
fd; IIHWNLITAFILRNATWFVVQLTMN CRFR_CHICK 158 7
fd; IIHWNLITTFILRNIMWFLLQMIDH CRF2_XENLA 152 7
fd; TLHKNMFLTYILNSMIIIIHLVEVV CALR_CAVPO 182 7
fd; TLHKNMFLTYILNSMIIIIHLVEVV CALR_HUMAN 198 23
fd; TLHKNMFLTYILNSMIIIIHLVEVV CALR_RABIT 182 7
fd; TLHKNMFLTYILNSIIIIIHLVEVV CALR_RAT 182 7
fd; TLHKHMFLTYILNSIIIIIHLVEVV CALR_MOUSE 182 7
fd; TLHKNMFLTYVLNSIIIIVHLVVIV CALR_PIG 199 23
fd; TIHTNLMSTYILSACSWILNLVLQN DIHR_MANSE 120 7
fd; TLHKNLFFSFVCNSVVTIIHLTAVA CGRR_HUMAN 175 7
fd; TLHKNLFFSFVCNSIVTIIHLTAVA CGRR_RAT 175 7
fd; TIHTNLMATYICNDATWIISAVVQE DIHR_ACHDO 167 7
fd; SIHKNLATAFVFRFAVLAIWTIVQT Q93245 91 26
bb;
fc; GPCRSECRETIN3
fl; 24
ft; Secretin motif III - 3
fd; AAVVFFQYCVMANFFWLLVEGLYL VIPR_RAT 218 16
fd; LVMIFFQYCIMANYAWLLVEGLYL SCRC_RAT 217 16
fd; LVMVLFQYCIMANYSWLLVEGLYL SCRC_HUMAN 217 16
fd; AVMVFFHYCVVSNYFWLFIEGLYL PACR_RAT 227 16
fd; AVMVFFHYCVVSNYFWLFIEGLYL PACR_MOUSE 228 16
fd; AVMVFFHYCVVSNYFWLFIEGLYL PACR_HUMAN 228 16
fd; AVMVFFHYCVMSNYFWLFIEGLYL O73769 220 16
fd; AVMVFFHYCVVSNYFWLFIEGLYL PACR_BOVIN 245 16
fd; LVMVFFQYCIMANYAWLLVEGLYL SCRC_RABIT 213 16
fd; AAMVFFQYCVMANFFWLLVEGLYL VIPR_HUMAN 217 16
fd; AAVVLFQYCVMANFFWLLVEGLYL VIPR_PIG 218 16
fd; LSLVFLQYCIMANFFWLLVEGLYL VIPS_HUMAN 204 19
fd; VAVTFFLYFLATNYYWILVEGLYL PTRR_HUMAN 283 37
fd; VAVTVFLYFLTTNYYWILVEGLYL PTRR_DIDMA 277 34
fd; VAVTFFLYFLATNYYWILVEGLYL PTRR_PIG 278 36
fd; AVIVFFQYCIMASFFWLLVEGLYL VIPR_CARAU 179 17
fd; LSLVFFQYCIMANFYWLLVEGLYL VIPS_MOUSE 203 19
fd; LSLVFFQYCIMANFYWLLVEGLYL VIPS_RAT 203 19
fd; VAVTFFLYFLATNYYWILVEGLYL PTRR_MOUSE 283 37
fd; VAVTFFLYFLATNYYWILVEGLYL PTRR_RAT 283 37
fd; TAVTFFQFCILTNYFWLLVEGLYL O73768 211 16
fd; TAQILTQYCVGANYTWLLVEGVYL GIPR_RAT 215 22
fd; TAQIVTQYCVGANYTWLLVEGVYL GIPR_HUMAN 218 22
fd; TAQIVTQYCVGANYTWLLVEGVYL GIPR_MESAU 215 22
fd; VATVIMQYGIIANYCWLLVEGVYL GLR_RAT 227 26
fd; LVFLLMQYCVAANYYWLLVEGVYL GLPR_RAT 228 25
fd; VATVIMQYGIIPNYCWLLVEGVYL GLR_MOUSE 227 26
fd; LVFLLMQYCVAANYYWLLVEGVYL GLPR_MOUSE 228 25
fd; VAAVFMQYGIVANYCWLLVEGLYL GLR_HUMAN 226 26
fd; LVFLLMQYCVAANYYWLLVEGVYL GLPR_HUMAN 228 25
fd; LVTAAYNYFHVTNFFWMFGEGCYL CRFR_MOUSE 190 12
fd; LVTAAYNYFHVTNFFWMFGEGCYL CRFR_SHEEP 190 12
fd; LVTAAYNYFHVTNFFWMFGEGCYL CRFR_HUMAN 219 12
fd; LVTAAYNYFHVTNFFWMFGEGCYL CRFR_RAT 190 12
fd; LVTIAHNYFYVTNFFWMFGEGCYL CRFR_XENLA 190 12
fd; CVTTIFNYFVVTNFFWMFVEGCYL CRF2_RAT 186 11
fd; IAVVMFIYFLATNYYWILVEGLYL PTR2_HUMAN 238 35
fd; VSVATSHFATMTNFSWLLAEAVYL GRFR_PIG 204 16
fd; CITTIFNYFVVTNFFWMFVEGCYL Q99431 213 11
fd; CITTIFNYFVVTNFFWMFVEGCYL O43461 172 11
fd; CITTIFNYFVVTNFFWMFVEGCYL CRF2_HUMAN 186 11
fd; VSVAASHFATMTNFSWLLAEAVYL GRFR_HUMAN 204 16
fd; IAVVMFIYFLATNYYWILVEGLYL PTH2_RAT 236 35
fd; VSVAVSHFATMTNFSWLLAEAVYL GRFR_RAT 204 16
fd; CITTIFNYFVVTNFFWMFVEGCYL CRF2_MOUSE 206 11
fd; VSVAISHLATMTNFSWLLAEAVYL GRFR_MOUSE 204 16
fd; LVTAAYNYFHVTNFFWMFGEGCYL CRFR_CHICK 195 12
fd; CITTIYNYFVVTNFFWMFVEGCYL CRF2_XENLA 188 11
fd; ILHFFHQYMMACNYFWMLCEGIYL CALR_CAVPO 221 14
fd; ILHFFHQYMMACNYFWMLCEGIYL CALR_HUMAN 237 14
fd; VLHFFHQYMMSCNYFWMLCEGIYL CALR_RABIT 221 14
fd; ILHFFHQYMMACNYFWMLCEGIYL CALR_RAT 258 51
fd; VLHFLHQYMMSCNYFWMLCEGIYL CALR_MOUSE 258 51
fd; VLHFFHQYMMSCNYFWMLCEGVYL CALR_PIG 238 14
fd; ILVICMNYFYLTNFFWMLVEGLYL DIHR_MANSE 158 13
fd; VSQFIHLYLMGCNYFWMLCEGIYL CGRR_HUMAN 214 14
fd; VSQFIHLYLMGCNYFWMLCEGIYL CGRR_RAT 214 14
fd; VLAVLMHYFYLTNFFWMFVEGLYL DIHR_ACHDO 201 9
fd; AILWFVIYFNVASVMWMLIEGAFL Q93245 139 23
bb;
fc; GPCRSECRETIN4
fl; 26
ft; Secretin motif IV - 3
fd; FWGYILIGWGVPSVFITIWTVVRIYF VIPR_RAT 256 14
fd; LQAFVLLGWGSPAIFVALWAITRHFL SCRC_RAT 255 14
fd; LQGFVAFGWGSPAIFVALWAIARHFL SCRC_HUMAN 255 14
fd; FYWYTIIGWGTPTVCVTVWAVLRLYF PACR_RAT 265 14
fd; FYWYTIIGWGTPTVCVTVWAVLRLYF PACR_MOUSE 266 14
fd; FYWYTIIGWGTPTVCVTVWATLRLYF PACR_HUMAN 266 14
fd; FYWYTIIGWGTPTICVTIWAVLRLHF O73769 258 14
fd; FYWYIIIGWGTPTVCVSVWAMLRLYF PACR_BOVIN 283 14
fd; LQGFVVLGWGSPAMFVTSWAVTRHFL SCRC_RABIT 251 14
fd; FWGYILIGWGVPSTFTMVWTIARIHF VIPR_HUMAN 255 14
fd; FWGYIFVGWGVPSTFIMVWTVVRIHF VIPR_PIG 256 14
fd; FLAYLLIGWGLPTVCIGAWTAARLYL VIPS_HUMAN 241 13
fd; LWGFTVFGWGLPAVFVAVWVSVRATL PTRR_HUMAN 321 14
fd; LWGFTLFGWGLPAVFVAVWVTVRATL PTRR_DIDMA 315 14
fd; LWGFTVFGWGLPAIFVAVWVSVRATL PTRR_PIG 316 14
fd; FWWYILIGWGGPTIFIMAWSFAKAYF VIPR_CARAU 217 14
fd; FLAYLLIGWGIPSVCIGAWTATRLSL VIPS_MOUSE 240 13
fd; FLAYLLIGWGIPSVCIGAWIATRLSL VIPS_RAT 240 13
fd; LWGFTIFGWGLPAVFVAVWVGVRATL PTRR_MOUSE 321 14
fd; LWGFTIFGWGLPAVFVAVWVGVRATL PTRR_RAT 321 14
fd; FWWYILIGWGVPSVVLIVWVLTRQFY O73768 249 14
fd; FRCYLLLGWGAPALFVIPWVIVRYLY GIPR_RAT 253 14
fd; FRYYLLLGWGAPALFVIPWVIVRYLY GIPR_HUMAN 256 14
fd; FRCYLLLGWGAPALFVIPWVIVRYLL GIPR_MESAU 253 14
fd; FSLYLCIGWGSPLLFVIPWVVVKCLF GLR_RAT 265 14
fd; FKLYLSIGWGVPLLFVIPWGIVKYLY GLPR_RAT 266 14
fd; FSLYLGIGWGAPLLFVIPWVVVKCLF GLR_MOUSE 265 14
fd; FKLYLSIGWGVPLLFVIPWGIVKYLY GLPR_MOUSE 266 14
fd; FSLYLGIGWGAPMLFVVPWAVVKCLF GLR_HUMAN 264 14
fd; FRLYVSIGWGVPLLFVVPWGIVKYLY GLPR_HUMAN 266 14
fd; KWMFVCIGWGVPFPIIVAWAIGKLYY CRFR_MOUSE 228 14
fd; KWMFICIGWGVPFPIIVAWAIGKLYY CRFR_SHEEP 228 14
fd; KWMFICIGWGVPFPIIVAWAIGKLYY CRFR_HUMAN 257 14
fd; KWMFVCIGWGVPFPIIVAWAIGKLHY CRFR_RAT 228 14
fd; KWMFICIGWCIPFPIIVAWAIGKLYY CRFR_XENLA 228 14
fd; KWLFLFIGWCIPCPIIVAWAVGKLYY CRF2_RAT 224 14
fd; LWGFILIGWGFPAAFVAAWAVARATL PTR2_HUMAN 276 14
fd; FWWLVLAGWGLPLLFTGTWVGCKLAF GRFR_PIG 242 14
fd; KCLFLFIGWCIPFPIIVAWAIGKLYY Q99431 251 14
fd; KCLFLFIGWCIPFPIIVAWAIGKLYY O43461 210 14
fd; KCLFLFIGWCIPFPIIVAWAIGKLYY CRF2_HUMAN 224 14
fd; FWWLVLAGWGLPVLFTGTWVSCKLAF GRFR_HUMAN 242 14
fd; LWGFILIGWGFPAVFVVAWAVARATL PTH2_RAT 274 14
fd; FWWLVLAGWGLPVLCTGTWVGCKLAF GRFR_RAT 242 14
fd; KWLFLFIGWCIPCPIIIAWAVGKLYY CRF2_MOUSE 244 14
fd; FWWLVLAGWGLPVLCTGTWVGCKHSF GRFR_MOUSE 242 14
fd; KWMFICIGWCIPFPIIVAWAIGKLYY CRFR_CHICK 233 14
fd; KWVFLFIGWCIPSPIIVTWAICKLFY CRF2_XENLA 226 14
fd; LRWYYLLGWGFPLVPTTIHAITRALY CALR_CAVPO 259 14
fd; LRWYYLLGWGFPLVPTTIHAITRAVY CALR_HUMAN 275 14
fd; LRWYYLLGWGFPLVPTTIHAITRAIY CALR_RABIT 259 14
fd; LRWYYLLGWGFPIVPTIIHAITRAVY CALR_RAT 296 14
fd; LRWYYLLGWGFPIVPTIIHAITRALY CALR_MOUSE 296 14
fd; LWWYHVLGWGFPLIPTTAHAITRAVL CALR_PIG 276 14
fd; LKVYTTIGWGAPAVFITIWVISRCFV DIHR_MANSE 196 14
fd; LMWYYFLGWGFPLIPACIHAIARSLY CGRR_HUMAN 252 14
fd; LMWYYFLGWGFPLLPACIHAIARSLY CGRR_RAT 252 14
fd; LQIYIIIGWGIPGVIVVTWAIIKHLG DIHR_ACHDO 239 14
fd; WSLYLACGWGVPFVVVTAWALVHQYI Q93245 178 15
bb;
fc; GPCRSECRETIN5
fl; 26
ft; Secretin motif V - 3
fd; WIIKAPILLSILVNFVLFICIIRILV VIPR_RAT 297 15
fd; WVIRGPVILSILINFIFFINILRILM SCRC_RAT 296 15
fd; WIIRGPVILSILINFILFINILRILM SCRC_HUMAN 296 15
fd; WVIKGPVVGSIMVNFVLFIGIIIILV PACR_RAT 306 15
fd; WVIKGPVVGSIMVNFVLFIGIIIILV PACR_MOUSE 307 15
fd; WVIKGPVVGSIMVNFVLFIGIIVILV PACR_HUMAN 307 15
fd; WVIKGPVVASIMINFVLFIGIIIILV O73769 299 15
fd; WVIKGPVVGSIMVNFVLFIGIIVILV PACR_BOVIN 324 15
fd; WVIRGPVILSILINFILFINILRILT SCRC_RABIT 292 15
fd; WIIKGPILTSILVNFILFICIIRILL VIPR_HUMAN 295 14
fd; WIIKAPILASILVNFILFIRIIGILV VIPR_PIG 296 14
fd; WVIRIPILISIIVNFVLFISIIRILL VIPS_HUMAN 282 15
fd; WIIQVPILASIVLNFILFINIVRVLA PTRR_HUMAN 361 14
fd; WIIQVPILAAIVVNFILFINIIRVLA PTRR_DIDMA 355 14
fd; WIIQVPILASIVLNFILFINIVRVLA PTRR_PIG 356 14
fd; WIIKTPILASILMNFILFICIIRILR VIPR_CARAU 259 16
fd; WVIRMPILISIVVNFALFISIVRILL VIPS_MOUSE 281 15
fd; WVIRMPILISIVVNFALFISIVRILL VIPS_RAT 281 15
fd; WIIQVPILASVVLNFILFINIIRVLA PTRR_MOUSE 361 14
fd; WIIQVPILASVVLNFILFINIIRVLA PTRR_RAT 361 14
fd; WIIKGPITVSLIANIIIFLNVIRILV O73768 290 15
fd; WIIRTPILITILINFLIFIRILGILV GIPR_RAT 294 15
fd; WIIRTPILMTILINFLIFIRILGILL GIPR_HUMAN 297 15
fd; WIIRTPILITILINFFIFIRILGILV GIPR_MESAU 294 15
fd; WILRIPVLLAILINFFIFVRIIHLLV GLR_RAT 306 15
fd; LIIRLPILFAIGVNFLVFIRVICIVI GLPR_RAT 307 15
fd; WILRIPVFLALLINFFIFVHIIQLLV GLR_MOUSE 306 15
fd; LIIRLPILFAIGVNFLIFIRVICIVV GLPR_MOUSE 307 15
fd; WILRFPVFLAILINFFIFVRIVQLLV GLR_HUMAN 305 15
fd; LIIRLPILFAIGVNFLIFVRVICIVV GLPR_HUMAN 307 15
fd; YIYQGPMILVLLINFIFLFNIVRILM CRFR_MOUSE 270 16
fd; YIYQGPMILVLLINFIFLFNIVRILM CRFR_SHEEP 270 16
fd; YIYQGPMILVLLINFIFLFNIVRILM CRFR_HUMAN 299 16
fd; YIYQGPMILVLLINFIFLFNIVRILM CRFR_RAT 270 16
fd; FIYQGPVILVLLINFIFLFNIVRILM CRFR_XENLA 270 16
fd; YIYQGPIILVLLINFVFLFNIVRILM CRF2_RAT 266 16
fd; WIYQAPILAAIGLNFILFLNTVRVLA PTR2_HUMAN 316 14
fd; WIIKGPIVLSVGVNFGLFLNIIRILL GRFR_PIG 283 15
fd; YIYQGPIILVLLINFVFLFNIVRILM Q99431 293 16
fd; YIYQGPIILVLLINFVFLFNIVRILM O43461 252 16
fd; YIYQGPIILVLLINFVFLFNIVRILM CRF2_HUMAN 266 16
fd; WIIKGPIVLSVGVNFGLFLNIIRILV GRFR_HUMAN 283 15
fd; WIYXXPILAAIGLNFILFLNTVRVLA PTH2_RAT 313 13
fd; WIIKGPIVLSVGVNFGLFLNIICILL GRFR_RAT 283 15
fd; YIYQGPVMLVLLINFVFLFNIVRILM CRF2_MOUSE 286 16
fd; WIIKGPIVLSVGVNFGLFLNIICILL GRFR_MOUSE 283 15
fd; YIYQGPMILVLLINFIFLFNIVRILM CRFR_CHICK 275 16
fd; YIYQGRVILVLLINFVFLFNIVRILM CRF2_XENLA 268 16
fd; YIIHGPVMVALVVNFFFLLNIVRVLV CALR_CAVPO 299 14
fd; YIIHGPVMAALVVNFFFLLNIVRVLV CALR_HUMAN 315 14
fd; YIIHGPVMAALVVNFFFLLNIVRVLV CALR_RABIT 299 14
fd; YIIHGPVMAALVVNFFFLLNIVRVLV CALR_RAT 336 14
fd; YIIHGPVMVALVVNFFFLLNIVRVLV CALR_MOUSE 336 14
fd; YIIHGPVMAALVVNFFFLLNILRVLV CALR_PIG 316 14
fd; WIHKAPALVGLALNLFFLIRIMWVLI DIHR_MANSE 251 29
fd; YIIHGPICAALLVNLFFLLNIVRVLI CGRR_HUMAN 292 14
fd; YIIHGPICAALLVNLFFLLNIVRVLI CGRR_RAT 292 14
fd; WIHQAPVITVLAVNLVFLFSIMWVLI DIHR_ACHDO 294 29
fd; WILAGTMGSALIMNLIFLLMIVVILV Q93245 223 19
bb;
fc; GPCRSECRETIN6
fl; 21
ft; Secretin motif VI - 3
fd; LAKSTLLLIPLFGIHYVMFAF VIPR_RAT 341 18
fd; LAKSTLLLIPLFGIHYIVFAF SCRC_RAT 340 18
fd; LARSTLLLIPLFGIHYIVFAF SCRC_HUMAN 340 18
fd; LARSTLLLIPLFGIHYTVFAF PACR_RAT 406 74
fd; LARSTLLLIPLFGIHYTVFAF PACR_MOUSE 379 46
fd; LARSTLLLIPLFGIHYTVFAF PACR_HUMAN 351 18
fd; LARSTLLLIPLFGIHYTVFAF O73769 343 18
fd; LARSTLLLIPLFGIHYTVFAF PACR_BOVIN 396 46
fd; LARSTLLLIPLFGVHYIVFVF SCRC_RABIT 336 18
fd; LARSTLLLIPLFGVHYIMFAF VIPR_HUMAN 339 18
fd; LAKSTLLLIPLFGVHYIMFAF VIPR_PIG 340 18
fd; LAKSTLLLIPLFGVHYMVFAV VIPS_HUMAN 326 18
fd; LLKSTLVLMPLFGVHYIVFMA PTRR_HUMAN 406 19
fd; LLKSTLVLMPLFGVHYIVFMA PTRR_DIDMA 400 19
fd; LLKSTLVLMPLFGVHYIVFMA PTRR_PIG 401 19
fd; LAKSTLLLIPLFGINFIIFAF VIPR_CARAU 303 18
fd; LAKSTLLLIPLFGVHYMVFAA VIPS_MOUSE 325 18
fd; LAKSTLLLIPLFGVHYMVFAA VIPS_RAT 325 18
fd; LLRSTLVLVPLFGVHYTVFMA PTRR_MOUSE 406 19
fd; LLRSTLVLVPLFGVHYTVFMA PTRR_RAT 406 19
fd; LAKSTLFLIPLFGMHYTLFAF O73768 334 18
fd; LARSTLTLMPLLGVHEVVFAP GIPR_RAT 336 16
fd; LARSTLTLVPLLGVHEVVFAP GIPR_HUMAN 339 16
fd; LARSTLTLVPLLGVHEVVFAP GIPR_MESAU 336 16
fd; LARSTLTLIPLLGVHEVVFAF GLR_RAT 348 16
fd; LAKSTLTLIPLLGTHEVIFAF GLPR_RAT 349 16
fd; LARSTLTLIPLLGVHEVVFAF GLR_MOUSE 348 16
fd; LAKSTLTLIPLLGTHEVIFAF GLPR_MOUSE 349 16
fd; LAKSTLTLIPLLGVHEVVFAF GLR_HUMAN 347 16
fd; LAKSTLTLIPLLGTHEVIFAF GLPR_HUMAN 349 16
fd; AVKATLVLLPLLGITYMLFFV CRFR_MOUSE 312 16
fd; AVKATLVLLPLLGITYMLFFV CRFR_SHEEP 312 16
fd; AVKATLVLLPLLGITYMLFFV CRFR_HUMAN 341 16
fd; AVKATLVLLPLLGITYMLFFV CRFR_RAT 312 16
fd; AVKATLVLLPLLGITYMLFFV CRFR_XENLA 312 16
fd; AVKATLVLLPLLGITYMLFFV CRF2_RAT 308 16
fd; LAKSTLVLVLVFGVHYIVFVC PTR2_HUMAN 361 19
fd; LSKSTLLLIPLFGIHYVIFNF GRFR_PIG 327 18
fd; AVKATLVLLPLLGITYMLFFV Q99431 335 16
fd; AVKATLVLLPLLGITYMLFFV O43461 294 16
fd; AVKATLVLLPLLGITYMLFFV CRF2_HUMAN 308 16
fd; LSKSTLFLIPLFGIHYIIFNF GRFR_HUMAN 327 18
fd; LAKSTLVLVLVFGVHYIVFIC PTH2_RAT 358 19
fd; LSKSTLLLIPLFGIHYIIFNF GRFR_RAT 368 59
fd; AVKATLVLLPLLGITYMLFFV CRF2_MOUSE 328 16
fd; LSKSTLLLIPLFGIHYIIFNF GRFR_MOUSE 327 18
fd; AVKATLVLLSLLGITYMLFFV CRFR_CHICK 317 16
fd; AVKATLVLLPLLGITYMLFFV CRF2_XENLA 310 16
fd; AVKATMILVPLLGIQFVVFPW CALR_CAVPO 341 16
fd; AVKATMILVPLLGIQFVVFPW CALR_HUMAN 357 16
fd; AVKATMILVPLLGIQFVVFPW CALR_RABIT 341 16
fd; AVKATMVLVPLLGIQFVVFPW CALR_RAT 378 16
fd; AVKATMVLVPLLGIQFVVFPW CALR_MOUSE 378 16
fd; AVRATLILVPLLGVQFVVLPW CALR_PIG 358 16
fd; ATKALLVLIPLLGITNLLVLC DIHR_MANSE 293 16
fd; AVRATLILVPLLGIEFVLIPW CGRR_HUMAN 334 16
fd; AVRATLILVPLLGIEFVLFPW CGRR_RAT 334 16
fd; ATKALLVLFPLLGITYILMMQ DIHR_ACHDO 336 16
fd; TIKATLLLVPLLGISNIPLFY Q93245 265 16
bb;
fc; GPCRSECRETIN7
fl; 22
ft; Secretin motif VII - 3
fd; MVFELVVGSFQGFVVAILYCFL VIPR_RAT 372 10
fd; LFFELALGSFQGLVVAVLYCFL SCRC_RAT 370 9
fd; LFFELALGSFQGLVVAVLYCFL SCRC_HUMAN 370 9
fd; LVFELGLGSFQGFVVAVLYCFL PACR_RAT 437 10
fd; LVFELGLGSFQGFVVAVLYCFL PACR_MOUSE 410 10
fd; LVFELGLGSFQGFVVAVLYCFL PACR_HUMAN 382 10
fd; LVFELGLGSFQGFVVAVLYCFL O73769 374 10
fd; LVFELGLGSFQGFVVAVLYCFL PACR_BOVIN 427 10
fd; LFFELALGSFQGLVVAVLYCFL SCRC_RABIT 366 9
fd; MVFELVVGSFQGFVVAILYCFL VIPR_HUMAN 370 10
fd; MVFELIVGSFQGCVVAILYCFL VIPR_PIG 371 10
fd; ILFELCLGSFQGLVVAVLYCFL VIPS_HUMAN 357 10
fd; MHYEMLFNSFQGFFVAIIYCFC PTRR_HUMAN 441 14
fd; MHYEMLFNSFQGFFVAIIYCFC PTRR_DIDMA 435 14
fd; MHYEMLFNSFQGFFVAIIYCFC PTRR_PIG 436 14
fd; LVFDLILGSFQGFVVAVLYCFL VIPR_CARAU 334 10
fd; ILFELCVGSFQGLVVAVLYCFL VIPS_MOUSE 356 10
fd; ILFELCVGSFQGLVVAVLYCFL VIPS_RAT 356 10
fd; MHYEMLFNSFQGFFVAIIYCFC PTRR_MOUSE 441 14
fd; MHYEMLFNSFQGFFVAIIYCFC PTRR_RAT 441 14
fd; FYIELGLGSFQGFVVALLYCFL O73768 365 10
fd; LAFEIFLSSFQGFLVSVLYCFI GIPR_RAT 371 14
fd; LGFEIFLSSFQGFLVSVLYCFI GIPR_HUMAN 374 14
fd; LAFEIFLSSFQGFLVSVLYCFI GIPR_MESAU 371 14
fd; LFFDLFFSSFQGLLVAVLYCFL GLR_RAT 383 14
fd; LFTELSFTSFQGFMVAVLYCFV GLPR_RAT 384 14
fd; LFFDLFLSSFQGLLVAVLYCFL GLR_MOUSE 383 14
fd; LFTELSFTSFQGLMVAILYCFV GLPR_MOUSE 384 14
fd; LFFDLFLSSFQGLLVAVLYCFL GLR_HUMAN 382 14
fd; LFTELSFTSFQGLMVAILYCFV GLPR_HUMAN 384 14
fd; IYFNSFLESFQGFFVSVFYCFL CRFR_MOUSE 345 12
fd; IYFNSFLESFQGFFVSVFYCFL CRFR_SHEEP 345 12
fd; IYFNSFLESFQGFFVSVFYCFL CRFR_HUMAN 374 12
fd; IYFNSFLESFQGFFVSVFYCFL CRFR_RAT 345 12
fd; IYFNSFLQSFQGFFVSVFYCFL CRFR_XENLA 345 12
fd; IYFNSFLQSFQGFFVSVFYCFF CRF2_RAT 341 12
fd; MHCELFFNSFQGFFVSIIYCYC PTR2_HUMAN 395 13
fd; LPLELGLGSFQGFIVAILYCFL GRFR_PIG 358 10
fd; IYFNSFLQSFQGFFVSVFYCFF Q99431 368 12
fd; IYFNSFLQSFQGFFVSVFYCFF O43461 327 12
fd; IYFNSFLQSFQGFFVSVFYCFF CRF2_HUMAN 341 12
fd; LPLELGLGSFQGFIVAILYCFL GRFR_HUMAN 358 10
fd; MHCELFFNSFQGFFVSIVYCYC PTH2_RAT 392 13
fd; LPLELGLGSFQGFVVAVLYCFL GRFR_RAT 399 10
fd; IYFNSFLQSFQGFFVSVFYCFF CRF2_MOUSE 361 12
fd; VPLELGLGSFQGFIVAVLYCFL GRFR_MOUSE 358 10
fd; IYFNSFLESFQGFFVSVFYCFL CRFR_CHICK 350 12
fd; IYFNSFLQSFQGFFVSVFYCFL CRF2_XENLA 343 12
fd; DYFMHSLIHFQGFFVATIYCFC CALR_CAVPO 373 11
fd; DYVMHSLIHFQGFFVATIYCFC CALR_HUMAN 389 11
fd; DYLMHSLIHFQGFFVATIYCFC CALR_RABIT 373 11
fd; DYLMHSLIHFQGFFVATIYCFC CALR_RAT 410 11
fd; DYLMHSLIHFQGFFVATIYCFC CALR_MOUSE 410 11
fd; DYVVHSLIHFQGFFVAIIYCFC CALR_PIG 390 11
fd; DYTRALMLSTQGFTVALFYCFM DIHR_MANSE 326 12
fd; DYIMHILMHFQGLLVSTIFCFF CGRR_HUMAN 366 11
fd; DYVMHILMHYQGLLVSTIFCFF CGRR_RAT 366 11
fd; RNAQALLLSLQGFTVALFYCFL DIHR_ACHDO 368 11
fd; MLGSAILQHSQGIFIAVLYCFL Q93245 295 9
bb;
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