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/*
* pp_hitseq.hh
*
* License: Artistic License, see file LICENSE.TXT or
* https://opensource.org/licenses/artistic-license-1.0
*
* Author : Oliver Keller
* Project : Gene Prediction with Protein Family Patterns
* Description: Data structures for storing ProteinProfile hit sequences
*/
#ifndef __PP_HITSEQ_HH
#define __PP_HITSEQ_HH
#include "pp_profile.hh"
#include <algorithm>
namespace PP {
/*
* HitSequence:
* consecutive sequence of block hits in the target sequence
* factor is the quotient of probabilities (block model vs. exon model)
* firstBlockIndex is the number of the first block of the sequence,
* posns contains positions from for block numbers first() to last()
*/
struct HitSequence {
HitSequence(int b, int from, const Double& p) :
factor(p),
firstBlockIndex(b),
posns(1, from)
{}
int first() const {
return firstBlockIndex;
}
int last() const {
return firstBlockIndex + posns.size() - 1;
}
int firstValue() const {
return posns.front();
}
int lastValue() const {
return posns.back();
}
// append a single hit to the sequence
void add(int from, Double p) {
posns.push_back(from);
factor *= p;
}
// append all hits from another sequence
void add(const HitSequence& from) {
copy(from.posns.begin(), from.posns.end(), back_inserter(posns));
factor *= from.factor;
}
int operator[] (int b) const {
return posns[b - firstBlockIndex];
}
Double getFactor() const {
return factor;
}
// position in the profile for a base coordinate specified by offset; returns
// (b,i) where b is the last block and i is the distance of lastValue() to the
// offset. i equals (block length + distance of block end to offset). Usually
// offset is the dna coordinate of the exon end.
Position targetPosAt(int offset) const {
return Position(last(), (offset +1 - lastValue())/3);
}
Double factor;
int firstBlockIndex;
vector<int> posns;
}; // PP::HitSequence
/*
* HitSequenceNode: data structure for navigation through a
* collection of hit sequences
*/
class HitSequenceNode {
protected:
/*
* iterators for HitSequenceNode's
*/
// ordinary iterator (ordering by first block)
class iterator {
public:
HitSequence& operator*() {
#ifdef DEBUG
if (node->item == 0)
throw ProjectError("invalid iterator end() dereferenced");
#endif
return *(node->item);
}
HitSequence* operator->() {
#ifdef DEBUG
if (node->item == 0)
throw ProjectError("invalid iterator end() dereferenced");
#endif
return node->item;
}
bool operator==(iterator other) {
return node==other.node;
}
iterator& operator=(iterator other) {
node=other.node;
return *this;
}
bool operator!=(iterator other) {
return node!=other.node;
}
iterator& operator++() {
node = node->next_by_first;
return *this;
}
iterator& operator--() {
node = node->previous_by_first;
return *this;
}
void erase() {
#ifdef DEBUG
if (node->item == 0)
throw ProjectError("tried to delete root");
#endif
node = node->next_by_first;
delete node->previous_by_first;
}
friend iterator createNode(const HitSequence&, iterator, iterator);
friend iterator createNode(int, int, const Double&, iterator, iterator);
iterator(HitSequenceNode* cur) : node(cur) {}
protected:
HitSequenceNode* node; // pointer to node containing current hit sequence
}; // PP::HitSequenceNode::iterator
// reverse iterator (ordering by first block)
struct reverse_iterator : iterator {
reverse_iterator(const iterator& it) : iterator(it) {}
HitSequence& operator*() {
#ifdef DEBUG
if (node->previous_by_first->item == 0)
throw ProjectError("invalid iterator rend() dereferenced");
#endif
return *(node->previous_by_first->item);
}
HitSequence* operator->() {
#ifdef DEBUG
if (node->previous_by_first->item == 0)
throw ProjectError("invalid iterator rend() dereferenced");
#endif
return node->previous_by_first->item;
}
reverse_iterator& operator++() {
node = node->previous_by_first;
return *this;
}
reverse_iterator operator++(int) {
node = node->previous_by_first;
return reverse_iterator(node->next_by_first);
}
reverse_iterator& operator--() {
node = node->next_by_first;
return *this;
}
reverse_iterator operator--(int) {
node = node->next_by_first;
return iterator(node->previous_by_first);
}
void erase() {
delete node->previous_by_first;
}
}; // PP::HitSequenceNode::reverse_iterator
// iterator for ordering by last block
struct last_iterator : iterator {
last_iterator(const iterator& it) : iterator(it) {}
last_iterator& operator++() {
node = node->next_by_last;
return *this;
}
last_iterator operator++(int) {
node = node->next_by_last;
return iterator(node->previous_by_last);
}
last_iterator& operator--() {
node = node->previous_by_last;
return *this;
}
void erase() {
#ifdef DEBUG
if (node->item == 0)
throw ProjectError("tried to delete root");
#endif
node = node->next_by_last;
delete node->previous_by_last;
}
}; // PP::HitSequenceNode::last_iterator
protected:
// constructors for HitSequenceNode
// can only be created by HitSequenceList
// or by createNode
HitSequenceNode() :
item(0),
previous_by_first(this),
next_by_first(this),
previous_by_last(this),
next_by_last(this) {
#ifdef DEBUG
if (previous_by_first != this || next_by_first != this || previous_by_last != this)
throw ProjectError("This shouldn't happen.");
#endif
}
HitSequenceNode(const HitSequence& seq,
HitSequenceNode* by_first, HitSequenceNode* by_last) :
item(new HitSequence(seq))
{
insert_this(by_first, by_last);
}
HitSequenceNode(int b, int i, const Double& p,
HitSequenceNode* by_first,
HitSequenceNode* by_last) :
item(new HitSequence(b,i,p))
{
insert_this(by_first, by_last);
}
// destructor
~HitSequenceNode() {
remove_this();
delete item;
}
void insert_this(HitSequenceNode* by_first,
HitSequenceNode* by_last) {
previous_by_first = by_first->previous_by_first;
next_by_first = by_first;
previous_by_last = by_last->previous_by_last;
next_by_last = by_last;
by_first->previous_by_first
= previous_by_first->next_by_first
= by_last->previous_by_last
= previous_by_last->next_by_last
= this;
}
void remove_this() {
previous_by_first->next_by_first = next_by_first;
next_by_first->previous_by_first = previous_by_first;
previous_by_last->next_by_last = next_by_last;
next_by_last->previous_by_last = previous_by_last;
}
#ifdef DEBUG
bool consistent() {
return
this == previous_by_first->next_by_first &&
this == next_by_first->previous_by_first &&
this == previous_by_last->next_by_last &&
this == next_by_last->previous_by_last;
}
#endif
friend iterator createNode(const HitSequence& hs, iterator it, iterator lit) {
return new HitSequenceNode(hs, it.node, lit.node);
}
friend iterator createNode(int b, int i, const Double& p, iterator it, iterator lit) {
return new HitSequenceNode(b, i, p, it.node, lit.node);
}
HitSequence* item; // hit sequence of the node
HitSequenceNode* previous_by_first; // hit sequences ordered by first block
HitSequenceNode* next_by_first;
HitSequenceNode* previous_by_last; // hit sequences ordered by last block
HitSequenceNode* next_by_last;
}; // PP::HitSequenceNode
/*
* HitSequenceList:
* this class is an entry point to a hit sequence collection
* the base node of the list is without HitSequence
*/
class HitSequenceList : private HitSequenceNode {
// friend class HitSequenceCollection;
public:
typedef HitSequenceNode::iterator iterator;
typedef HitSequenceNode::reverse_iterator reverse_iterator;
typedef HitSequenceNode::last_iterator last_iterator;
// constructor and destructor
HitSequenceList() :
HitSequenceNode(),
activeMax(this) {
#ifdef DEBUG
if (previous_by_first != this)
throw ProjectError("This shouldn't happen!");
#endif
}
~HitSequenceList() {
while (next_by_first != this)
begin().erase();
while (next_by_last != this)
lbegin().erase();
}
// iterator methods
iterator begin() {
return next_by_first;
}
iterator end() {
return this;
}
reverse_iterator rbegin() {
return end();
}
reverse_iterator rend() {
return begin();
}
last_iterator lbegin() {
return iterator(next_by_last);
}
last_iterator lend() {
return end();
}
void init() {
activeMax = rbegin();
}
bool inactive() {
return activeMax == rend();
}
void setInactive(reverse_iterator it) {
activeMax = it;
}
reverse_iterator rbeginActive() {
return activeMax;
}
bool empty() {
return begin() == end();
}
#ifdef DEBUG
bool inconsistent() {
return item != 0;
}
#endif
private:
reverse_iterator activeMax; // end of the active elements of the list
}; // PP::HitSequenceList
/*
* HitSequenceCollection:
* this class contains all hit sequences for a given reading frame
* ordered by block number (one HitSequenceList for each block number
* to access them ordered by first and last block positions)
*/
class HitSequenceCollection {
public:
HitSequenceCollection(int size=0) {
reset(size);
}
~HitSequenceCollection() {
deleteNodes();
}
void addSingle(int b, int offset, const Double& val) {
createNode(b, offset, val, end(b), lbegin(b));
}
void addSingleFront(int b, int offset, const Double& val) {
createNode(b, offset, val, begin(b), lend(b));
}
void addHit(int b, int offset, Double val, DistanceType iBD, int blocksize);
void addHitFront(int b, int offset, Double val, DistanceType iBD);
void init() {
for (unsigned b=0; b<lists.size(); b++)
lists[b]->init();
}
void deleteNodes() {
for (unsigned b=0; b<lists.size(); b++)
delete lists[b];
}
private:
static HitSequenceList* newlist() {
return new HitSequenceList();
}
public:
void reset(int size) {
deleteNodes();
lists.resize(size);
generate_n(lists.begin(), size, &newlist);
}
void reset() {
deleteNodes();
generate(lists.begin(), lists.end(), &newlist);
}
// iterator methods
HitSequenceList::iterator begin(int b) {
return list(b).begin();
}
HitSequenceList::iterator end(int b) {
return list(b).end();
}
HitSequenceList::reverse_iterator rbegin(int b) {
return list(b).rbegin();
}
HitSequenceList::reverse_iterator rend(int b) {
return list(b).rend();
}
HitSequenceList::last_iterator lbegin(int b) {
return list(b).lbegin();
}
HitSequenceList::last_iterator lend(int b) {
return list(b).lend();
}
HitSequenceList& list(int b) {
#ifdef DEBUG
if (lists[b]->inconsistent())
throw ProjectError("root has nonzero item!");
#endif
return *lists.at(b);
}
private:
vector<HitSequenceList*> lists;
}; // PP::HitSequenceCollection
} // namespace PP
#endif
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