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<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01//EN">
<html>
<head>
<meta name="generator" content=
"HTML Tidy for Linux (vers 25 March 2009), see www.w3.org">
<title>Headache</title>
<link rel="stylesheet" href="../css/style.css" type="text/css">
</head>
<body>
<div class="navigation" id="breadcrumb">
<a href=
"index.html?action=clearAll&module=common_functions">Main Page</a> > Headache I
</div>
<div id="text-content">
<h1>Headache</h1>
<p class="functionality">
In the human body, a headache is signalized by so-called <b>prostaglandins</b>.
Prostaglandins are locally acting messenger molecules.
They are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue. Moreover, they sensitize nerve endings that transmit pain signals to the brain. <br>
Prostaglandin is generated by the enzyme cyclooxygenase (COX).
Pharmacological inhibition of COX-2 can provide relief from the symptoms of inflammation and pain, since the prostaglandin synthesis is prevented and no pain signals can be transmitted to the brain. </p>
<p class="step">
The area in the COX-2 enzyme, where prostaglandins are produced, is called the <b>binding pocket</b> of the enzyme. It is the center of the enzym's activity and you can compare it to a lock, where only a suitable key, namely the drug molecule, can fit. <br></p>
<div class="task">
Click <a href=
"aspirin.html?action=toggleSelectionByExpression&module=common_functions&expression=residueID(116)%20OR%20residueID(349)%20OR%20residueID(352)%20OR%20residueID(355)%20OR%20residueID(358)%20OR%20residueID(359)%20OR%20residueID(523)%20OR%20residueID(527)%20OR%20residueID(530)%20OR%20residueID(531)">
here</a>, to see the colored binding pocket.
</div><br>
<div class="task">
How huge do you imagine the molecule fitting in this
<a href=
"aspirin.html?action=toggleSelectionByExpression&module=common_functions&expression=residueID(116)%20OR%20residueID(349)%20OR%20residueID(352)%20OR%20residueID(355)%20OR%20residueID(358)%20OR%20residueID(359)%20OR%20residueID(523)%20OR%20residueID(527)%20OR%20residueID(530)%20OR%20residueID(531)">
binding pocket?</a> <br>
Use the computer mouse to have a closer look at COX-2 and its binding pocket.
</div>
<div class="task">
Can you discover the pharmaceutical agent in the binding pocket?
</div><br>
<br>
On the next page you can learn more about drugs to treat headaches. <br>
<br>
<a href=
"aspirin2.html?action=loadProject&module=common_functions&filename=projects/Sal_X.bvp">
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