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package assemble;
import java.util.Arrays;
import java.util.concurrent.atomic.AtomicIntegerArray;
import dna.AminoAcid;
import kmer.AbstractKmerTable;
import kmer.AbstractKmerTableSet;
import kmer.HashArray1D;
import kmer.HashForest;
import kmer.KmerNode;
import kmer.KmerTableSet;
import shared.Tools;
import structures.ByteBuilder;
import ukmer.Kmer;
/**
* Designed for removal of dead ends (aka hairs).
* @author Brian Bushnell
* @date Jun 26, 2015
*
*/
public class Shaver1 extends Shaver {
/*--------------------------------------------------------------*/
/*---------------- Constructor ----------------*/
/*--------------------------------------------------------------*/
public Shaver1(KmerTableSet tables_, int threads_){
this(tables_, threads_, 1, 1, 1, 1, 3, 100, 100, true, true);
}
public Shaver1(KmerTableSet tables_, int threads_,
int minCount_, int maxCount_, int minSeed_, int minCountExtend_, float branchMult2_, int maxLengthToDiscard_, int maxDistanceToExplore_,
boolean removeHair_, boolean removeBubbles_){
super(tables_, threads_, minCount_, maxCount_, minSeed_, minCountExtend_, branchMult2_, maxLengthToDiscard_, maxDistanceToExplore_, removeHair_, removeBubbles_);
tables=tables_;
k=tables.k;
}
/*--------------------------------------------------------------*/
/*---------------- Outer Methods ----------------*/
/*--------------------------------------------------------------*/
@Override
final AbstractExploreThread makeExploreThread(int id_){return new ExploreThread(id_);}
@Override
final AbstractShaveThread makeShaveThread(int id_){return new ShaveThread(id_);}
/*--------------------------------------------------------------*/
/*---------------- Dead-End Removal ----------------*/
/*--------------------------------------------------------------*/
public boolean exploreAndMark(long kmer, ByteBuilder bb, int[] leftCounts, int[] rightCounts, int minCount, int maxCount,
int maxLengthToDiscard, int maxDistanceToExplore, boolean prune,
long[][] countMatrixT, long[][] removeMatrixT){
bb.clear();
if(findOwner(kmer)>STATUS_UNEXPLORED){return false;}
bb.appendKmer(kmer, k);
final int rightCode=explore(kmer, bb, leftCounts, rightCounts, minCount, maxCount, maxDistanceToExplore);
bb.reverseComplementInPlace();
kmer=tables.rightmostKmer(bb);
final int leftCode=explore(kmer, bb, leftCounts, rightCounts, minCount, maxCount, maxDistanceToExplore);
final int min=Tools.min(rightCode, leftCode);
final int max=Tools.max(rightCode, leftCode);
countMatrixT[min][max]++;
if(rightCode==TOO_LONG || rightCode==TOO_DEEP || rightCode==LOOP || rightCode==F_BRANCH){
claim(bb, STATUS_EXPLORED, false);
return false;
}
if(leftCode==TOO_LONG || leftCode==TOO_DEEP || leftCode==LOOP || leftCode==F_BRANCH){
claim(bb, STATUS_EXPLORED, false);
return false;
}
if(bb.length()-k>maxLengthToDiscard){
claim(bb, STATUS_EXPLORED, false);
return false;
}
if(removeHair && min==DEAD_END){
if(max==DEAD_END || max==B_BRANCH){
removeMatrixT[min][max]++;
boolean success=claim(bb, STATUS_REMOVE, false);
if(verbose || verbose2){System.err.println("Claiming ("+rightCode+","+leftCode+") length "+bb.length()+": "+bb);}
assert(success);
return true;
}
}
if(removeBubbles){
if(rightCode==B_BRANCH && leftCode==B_BRANCH){
removeMatrixT[min][max]++;
boolean success=claim(bb, STATUS_REMOVE, false);
if(verbose || verbose2){System.err.println("Claiming ("+rightCode+","+leftCode+") length "+bb.length()+": "+bb);}
assert(success);
return true;
}
}
claim(bb, STATUS_EXPLORED, false);
return false;
}
/** Explores a single unbranching path in the forward direction.
* @param kmer
* @param bb
* @param leftCounts
* @param rightCounts
* @param minCount
* @param maxCount
* @param maxLength0
* @return A termination code such as DEAD_END
*/
public int explore(long kmer, ByteBuilder bb, int[] leftCounts, int[] rightCounts, int minCount, int maxCount, int maxLength0){
if(verbose){outstream.println("Entering explore with bb.length()="+bb.length());}
assert(bb.length()==0 || tables.rightmostKmer(bb)==kmer);
if(bb.length()==0){bb.appendKmer(kmer, k);}
final int initialLength=bb.length();
final int maxLength=maxLength0+k;
final int shift=2*k;
final int shift2=shift-2;
final long mask=(shift>63 ? -1L : ~((-1L)<<shift));
long rkmer=AminoAcid.reverseComplementBinaryFast(kmer, k);
long key=toValue(kmer, rkmer);
final long firstKey=key;
HashArray1D table=tables.getTableForKey(key);
int count=table.getValue(key);
assert(count>=minCount && count<=maxCount);
int nextRightMaxPos=fillRightCounts(kmer, rkmer, rightCounts, mask, shift2);
int nextRightMax=rightCounts[nextRightMaxPos];
if(nextRightMax<minCount){
if(verbose){outstream.println("Returning DEAD_END: rightMax="+nextRightMax);}
return DEAD_END;
}
while(bb.length()<=maxLength){
final int rightMaxPos=nextRightMaxPos;
final int rightMax=nextRightMax;
final int rightSecondPos=Tools.secondHighestPosition(rightCounts);
final int rightSecond=rightCounts[rightSecondPos];
final int prevCount=count;
count=rightMax;
if(verbose){
outstream.println("kmer: "+toText(kmer, k)+", "+toText(rkmer, k));
outstream.println("Right counts: "+prevCount+", "+Arrays.toString(rightCounts));
outstream.println("rightMaxPos="+rightMaxPos);
outstream.println("rightMax="+rightMax);
outstream.println("rightSecondPos="+rightSecondPos);
outstream.println("rightSecond="+rightSecond);
}
//Generate the new base
final byte b=AminoAcid.numberToBase[rightMaxPos];
final long x=rightMaxPos;
final long x2=AminoAcid.numberToComplement[rightMaxPos];
kmer=((kmer<<2)|(long)x)&mask;
rkmer=((rkmer>>>2)|(x2<<shift2))&mask;
//Now consider the next kmer
key=toValue(kmer, rkmer);
if(key==firstKey){
if(verbose){outstream.println("Returning LOOP");}
return LOOP;
}
table=tables.getTableForKey(key);
assert(table.getValue(key)==rightMax || rightMax==0);
{//Fill right and look for dead end
nextRightMaxPos=fillRightCounts(kmer, rkmer, rightCounts, mask, shift2);
nextRightMax=rightCounts[nextRightMaxPos];
if(nextRightMax<minCount){
if(verbose){outstream.println("Returning DEAD_END: rightMax="+rightMax);}
return DEAD_END;
}
}
{//Look left
final int leftMaxPos=fillLeftCounts(kmer, rkmer, leftCounts, mask, shift2);
final int leftMax=leftCounts[leftMaxPos];
final int leftSecondPos=Tools.secondHighestPosition(leftCounts);
final int leftSecond=leftCounts[leftSecondPos];
// assert(leftMax==1 || leftMax==0) : prevCount+" -> "+Arrays.toString(leftCounts)+", "+count+", "+Arrays.toString(rightCounts);
if(verbose){
outstream.println("Left counts: "+count+", "+Arrays.toString(leftCounts));
outstream.println("leftMaxPos="+leftMaxPos);
outstream.println("leftMax="+leftMax);
outstream.println("leftSecondPos="+leftSecondPos);
outstream.println("leftSecond="+leftSecond);
}
if(leftSecond>=minCount || leftMax>prevCount){//Backward branch
// assert(leftSecond==1) : prevCount+" -> "+Arrays.toString(leftCounts)+", "+count+", "+Arrays.toString(rightCounts);
if(leftMax>prevCount){
if(verbose){outstream.println("Returning B_BRANCH_LOWER: " +
"count="+count+", prevCount="+prevCount+", leftMax="+leftMax+", leftSecond="+leftSecond);}
return B_BRANCH;
}else{
assert(leftMax==prevCount);
if(leftMax>=2*leftSecond){//This constant is adjustable
// assert(false) : prevCount+" -> "+Arrays.toString(leftCounts)+", "+count+", "+Arrays.toString(rightCounts);
//keep going
}else{
if(verbose){outstream.println("Returning B_BRANCH_SIMILAR: " +
"count="+count+", prevCount="+prevCount+", leftMax="+leftMax+", leftSecond="+leftSecond);}
return B_BRANCH;
}
}
}
}
//Look right
if(rightSecond>=minCount){
if(verbose){outstream.println("Returning F_BRANCH: rightSecond="+rightSecond);}
return F_BRANCH;
}
if(count>maxCount){
if(verbose){outstream.println("Returning TOO_DEEP: rightMax="+rightMax);}
return TOO_DEEP;
}
bb.append(b);
if(verbose){outstream.println("Added base "+(char)b);}
}
assert(bb.length()>maxLength);
if(verbose){outstream.println("Returning TOO_LONG: length="+bb.length());}
return TOO_LONG;
}
/** Explores a single unbranching path in the forward direction.
* Returns reason for ending in this direction:
* DEAD_END, TOO_LONG, TOO_DEEP, F_BRANCH, B_BRANCH */
public int explore2(long kmer, ByteBuilder bb, int[] leftCounts, int[] rightCounts, int minCount, int maxCount, int maxLength0){
if(verbose){outstream.println("Entering explore with bb.length()="+bb.length());}
assert(bb.length()==0 || tables.rightmostKmer(bb)==kmer);
if(bb.length()==0){bb.appendKmer(kmer, k);}
final int maxLength=maxLength0+k;
final int shift=2*k;
final int shift2=shift-2;
final long mask=(shift>63 ? -1L : ~((-1L)<<shift));
long rkmer=AminoAcid.reverseComplementBinaryFast(kmer, k);
long key=toValue(kmer, rkmer);
final long firstKey=key;
HashArray1D table=tables.getTableForKey(key);
int count=table.getValue(key);
assert(count>=minCount && count<=maxCount);
int rightMaxPos=fillRightCounts(kmer, rkmer, rightCounts, mask, shift2);
int rightMax=rightCounts[rightMaxPos];
int rightSecondPos=Tools.secondHighestPosition(rightCounts);
int rightSecond=rightCounts[rightSecondPos];
if(verbose){
outstream.println("kmer: "+toText(kmer, k)+", "+toText(rkmer, k));
outstream.println("Right counts: "+count+", "+Arrays.toString(rightCounts));
outstream.println("rightMaxPos="+rightMaxPos);
outstream.println("rightMax="+rightMax);
outstream.println("rightSecondPos="+rightSecondPos);
outstream.println("rightSecond="+rightSecond);
}
if(rightMax<minCount){
if(verbose){outstream.println("Returning DEAD_END: rightMax="+rightMax);}
return DEAD_END;
}else if(rightSecond>=minCount){
if(verbose){outstream.println("Returning F_BRANCH: rightSecond="+rightSecond);}
return F_BRANCH;
}else if(rightMax>maxCount){
if(verbose){outstream.println("Returning TOO_DEEP: rightMax="+rightMax);}
return TOO_DEEP;
}
while(bb.length()<=maxLength){
final int prevCount=count;
//Generate the new base
final byte b=AminoAcid.numberToBase[rightMaxPos];
final long x=rightMaxPos;
final long x2=AminoAcid.numberToComplement[rightMaxPos];
kmer=((kmer<<2)|(long)x)&mask;
rkmer=((rkmer>>>2)|(x2<<shift2))&mask;
//Now consider the next kmer
key=toValue(kmer, rkmer);
if(key==firstKey){
if(verbose){outstream.println("Returning LOOP");}
return LOOP;
}
table=tables.getTableForKey(key);
assert(table.getValue(key)==rightMax || rightMax==0);
count=rightMax;
{//Look right
rightMaxPos=fillRightCounts(kmer, rkmer, rightCounts, mask, shift2);
rightMax=rightCounts[rightMaxPos];
rightSecondPos=Tools.secondHighestPosition(rightCounts);
rightSecond=rightCounts[rightSecondPos];
if(verbose){
outstream.println("kmer: "+toText(kmer, k)+", "+toText(rkmer, k));
outstream.println("Right counts: "+count+", "+Arrays.toString(rightCounts));
outstream.println("rightMaxPos="+rightMaxPos);
outstream.println("rightMax="+rightMax);
outstream.println("rightSecondPos="+rightSecondPos);
outstream.println("rightSecond="+rightSecond);
}
if(rightMax<minCount){
if(verbose){outstream.println("Returning DEAD_END: rightMax="+rightMax);}
return DEAD_END;
}else if(rightSecond>=minCount){
if(verbose){outstream.println("Returning F_BRANCH: rightSecond="+rightSecond);}
return F_BRANCH;
}
}
{//Look left
int leftMaxPos=fillLeftCounts(kmer, rkmer, leftCounts, mask, shift2);
int leftMax=leftCounts[leftMaxPos];
int leftSecondPos=Tools.secondHighestPosition(leftCounts);
int leftSecond=leftCounts[leftSecondPos];
// assert(leftMax==1 || leftMax==0) : prevCount+" -> "+Arrays.toString(leftCounts)+", "+count+", "+Arrays.toString(rightCounts);
if(verbose){
outstream.println("Left counts: "+count+", "+Arrays.toString(leftCounts));
outstream.println("leftMaxPos="+leftMaxPos);
outstream.println("leftMax="+leftMax);
outstream.println("leftSecondPos="+leftSecondPos);
outstream.println("leftSecond="+leftSecond);
}
if(leftSecond>=minCount){//Backward branch
// assert(leftSecond==1) : prevCount+" -> "+Arrays.toString(leftCounts)+", "+count+", "+Arrays.toString(rightCounts);
if(leftMax>prevCount){
if(verbose){outstream.println("Returning B_BRANCH_LOWER: " +
"count="+count+", prevCount="+prevCount+", leftMax="+leftMax+", leftSecond="+leftSecond);}
return B_BRANCH;
}else{
assert(leftMax==prevCount);
if(leftMax>=2*leftSecond){//This constant is adjustable
// assert(false) : prevCount+" -> "+Arrays.toString(leftCounts)+", "+count+", "+Arrays.toString(rightCounts);
//keep going
}else{
if(verbose){outstream.println("Returning B_BRANCH_SIMILAR: " +
"count="+count+", prevCount="+prevCount+", leftMax="+leftMax+", leftSecond="+leftSecond);}
return B_BRANCH;
}
}
}
}
if(count>maxCount){
if(verbose){outstream.println("Returning TOO_DEEP: rightMax="+rightMax);}
return TOO_DEEP;
}
bb.append(b);
if(verbose){outstream.println("Added base "+(char)b);}
}
assert(bb.length()>maxLength);
if(verbose){outstream.println("Returning TOO_LONG: length="+bb.length()+", rightMax="+rightMax);}
return TOO_LONG;
}
/*--------------------------------------------------------------*/
/*---------------- Inner Classes ----------------*/
/*--------------------------------------------------------------*/
/*--------------------------------------------------------------*/
/*---------------- ExploreThread ----------------*/
/*--------------------------------------------------------------*/
/**
* Searches for dead ends.
*/
class ExploreThread extends AbstractExploreThread{
/**
* Constructor
*/
public ExploreThread(int id_){
super(id_, k);
shift=2*k;
shift2=shift-2;
mask=(shift>63 ? -1L : ~((-1L)<<shift));
}
@Override
boolean processNextTable(Kmer kmer, Kmer temp){
final int tnum=nextTable.getAndAdd(1);
if(tnum>=tables.ways){return false;}
final HashArray1D table=tables.getTable(tnum);
final int max=table.arrayLength();
if(startFromHighCounts){
for(int cell=0; cell<max; cell++){
int x=processCell_high(table, cell);
deadEndsFoundT+=x;
}
}else{
for(int cell=0; cell<max; cell++){
int x=processCell_low(table, cell);
deadEndsFoundT+=x;
}
}
return true;
}
@Override
boolean processNextVictims(Kmer kmer, Kmer temp){
final int tnum=nextVictims.getAndAdd(1);
if(tnum>=tables.ways){return false;}
final HashArray1D table=tables.getTable(tnum);
final HashForest forest=table.victims();
final int max=forest.arrayLength();
if(startFromHighCounts){
for(int cell=0; cell<max; cell++){
KmerNode kn=forest.getNode(cell);
int x=traverseKmerNode_high(kn);
deadEndsFoundT+=x;
}
}else{
for(int cell=0; cell<max; cell++){
KmerNode kn=forest.getNode(cell);
int x=traverseKmerNode_low(kn);
deadEndsFoundT+=x;
}
}
return true;
}
private int traverseKmerNode_high(KmerNode kn){
int sum=0;
if(kn!=null){
sum+=processKmerNode_high(kn);
if(kn.left()!=null){
sum+=traverseKmerNode_high(kn.left());
}
if(kn.right()!=null){
sum+=traverseKmerNode_high(kn.right());
}
}
return sum;
}
private int traverseKmerNode_low(KmerNode kn){
int sum=0;
if(kn!=null){
sum+=processKmerNode_low(kn);
if(kn.left()!=null){
sum+=traverseKmerNode_low(kn.left());
}
if(kn.right()!=null){
sum+=traverseKmerNode_low(kn.right());
}
}
return sum;
}
/*--------------------------------------------------------------*/
//old
private int processCell_low(HashArray1D table, int cell){
int count=table.readCellValue(cell);
if(count<minSeed || count>maxCount){return 0;}
int owner=table.getCellOwner(cell);
if(owner>STATUS_UNEXPLORED){return 0;}
long key=table.getKmer(cell);
if(verbose){outstream.println("id="+id+" processing cell "+cell+"; \tkmer="+key+"\t"+AminoAcid.kmerToString(key, k));}
return processKmer_low(key);
}
//old
private int processKmerNode_low(KmerNode kn){
final long key=kn.pivot();
final int count=kn.getValue(key);
if(count<minSeed || count>maxCount){return 0;}
int owner=kn.getOwner(key);
if(owner>STATUS_UNEXPLORED){return 0;}
return processKmer_low(key);
}
//old
private int processKmer_low(long key){
kmersTestedT++;
boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts, minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true
, countMatrixT, removeMatrixT
);
return b ? 1 : 0;
}
/*--------------------------------------------------------------*/
//new
private int processCell_high(HashArray1D table, int cell){
int count=table.readCellValue(cell);
if(count<=maxCount){return 0;}
if(shaveFast && maxCount==1 && count>=6){return 0;}
// int owner=table.getCellOwner(cell);
// if(owner>STATUS_UNEXPLORED){return 0;}
long key=table.getKmer(cell);
if(verbose){outstream.println("id="+id+" processing cell "+cell+"; \tkmer="+key+"\t"+AminoAcid.kmerToString(key, k));}
return processKmer_high(key);
}
//new
private int processKmerNode_high(KmerNode kn){
final long key=kn.pivot();
final int count=kn.getValue(key);
if(count<=maxCount){return 0;}
if(shaveFast && maxCount==1 && count>=6){return 0;}
// int owner=kn.getOwner(key);
// if(owner>STATUS_UNEXPLORED){return 0;}
return processKmer_high(key);
}
// //new
// private int processKmer_high(final long key0){
// if(!tables.MASK_CORE){return processKmer_high_safe(key0);}
// final int shift=2*k;
// final int shift2=shift-2;
// final long mask=(shift>63 ? -1L : ~((-1L)<<shift));
// int sum=0;
// final long kmer0=key0;
// final long rkmer0=AminoAcid.reverseComplementBinaryFast(key0, k);
//// fillRightCounts(kmer0, kmer0, rightCounts, mask, shift2);
// {
// final long kmer1=(kmer0<<2)&mask;
// final long rkmer1=(rkmer0>>2);
// if((kmer1&tables.coreMask)==(rkmer1&tables.coreMask)){return processKmer_high_safe(key0);}
// final long key1=toValue(kmer1|3, rkmer1);
// final int way=tables.kmerToWay(key1);
// final HashArray1D table=(HashArray1D) tables.tables()[way];
// final int cell=table.kmerToCell(key1);
// for(long i=0, j=3; i<4; i++, j--){
// long kmer=kmer1|i;
// long rkmer=rkmer1|(j<<shift2);
//// long kmer=((kmer0<<2)|i)&mask;
//// long rkmer=(rkmer0>>2)|(j<<shift2);
// long key=toValue(kmer, rkmer);
//// int way=tables.kmerToWay(key);
//// HashArray1D table=(HashArray1D) tables.tables()[way];
// int count=table.getValue(key, cell);
// if(count>0 && count<=maxCount && table.getOwner(key)<=STATUS_UNEXPLORED){
// kmersTestedT++;
// boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts,
// minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true,
// countMatrixT, removeMatrixT);
// if(b){sum++;}
// }
// }
// }
// {
// final long rkmer1=(rkmer0<<2)&mask;
// final long kmer1=(kmer0>>2);
// if((kmer1&tables.coreMask)==(rkmer1&tables.coreMask)){return processKmer_high_safe(key0);}
// final long key1=toValue(kmer1, rkmer1|3);
// final int way=tables.kmerToWay(key1);
// final HashArray1D table=(HashArray1D) tables.tables()[way];
// final int cell=table.kmerToCell(key1);
// for(long i=0, j=3; i<4; i++, j--){
// long rkmer=rkmer1|i;
// long kmer=kmer1|(j<<shift2);
//// long rkmer=((rkmer0<<2)|i)&mask;
//// long kmer=(kmer0>>2)|(j<<shift2);
// long key=toValue(kmer, rkmer);
//// int way=tables.kmerToWay(key);
//// HashArray1D table=(HashArray1D) tables.tables()[way];
// int count=table.getValue(key, cell);
// if(count>0 && count<=maxCount && table.getOwner(key)<=STATUS_UNEXPLORED){
// kmersTestedT++;
// boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts,
// minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true,
// countMatrixT, removeMatrixT);
// if(b){sum++;}
// }
// }
// }
// return sum;
// }
//new
private int processKmer_high(final long key0){
if(!tables.MASK_CORE){return processKmer_high_safe(key0);}
final long kmer0=key0;
final long rkmer0=AminoAcid.reverseComplementBinaryFast(key0, k);
int sum=0;
sum+=processKmer_high_leftLoop(kmer0, rkmer0);
sum+=processKmer_high_leftLoop(rkmer0, kmer0);
return sum;
}
private int processKmer_high_leftLoop(final long kmer0, final long rkmer0){
int sum=0;
final long rkmer1=(rkmer0<<2)&mask;
final long kmer1=(kmer0>>2);
if((kmer1&tables.coreMask)==(rkmer1&tables.coreMask)){return processKmer_high_safe(kmer0);}
final long key1=toValue(kmer1, rkmer1|3);
final int way=tables.kmerToWay(key1);
final HashArray1D table=(HashArray1D) tables.tables()[way];
final int cell=table.kmerToCell(key1);
for(long i=0, j=3; i<4; i++, j--){
long rkmer=rkmer1|i;
long kmer=kmer1|(j<<shift2);
// long rkmer=((rkmer0<<2)|i)&mask;
// long kmer=(kmer0>>2)|(j<<shift2);
long key=toValue(kmer, rkmer);
// int way=tables.kmerToWay(key);
// HashArray1D table=(HashArray1D) tables.tables()[way];
int count=table.getValue(key, cell);
if(count>0 && count<=maxCount && table.getOwner(key)<=STATUS_UNEXPLORED){
kmersTestedT++;
boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts,
minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true,
countMatrixT, removeMatrixT);
if(b){sum++;}
}
}
return sum;
}
// //new
// private int processKmer_high_safe(final long key0){
// final int shift=2*k;
// final int shift2=shift-2;
// final long mask=(shift>63 ? -1L : ~((-1L)<<shift));
// int sum=0;
// final long kmer0=key0;
// final long rkmer0=AminoAcid.reverseComplementBinaryFast(key0, k);
// {
// final long kmer1=(kmer0<<2)&mask;
// final long rkmer1=(rkmer0>>2);
// for(long i=0, j=3; i<4; i++, j--){
// long kmer=kmer1|i;
// long rkmer=rkmer1|(j<<shift2);
// long key=toValue(kmer, rkmer);
// int way=tables.kmerToWay(key);
// HashArray1D table=(HashArray1D) tables.tables()[way];
// int count=table.getValue(key);
// if(count>0 && count<=maxCount && table.getOwner(key)<=STATUS_UNEXPLORED){
// kmersTestedT++;
// boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts,
// minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true,
// countMatrixT, removeMatrixT);
// if(b){sum++;}
// }
// }
// }
// {
// final long rkmer1=(rkmer0<<2)&mask;
// final long kmer1=(kmer0>>2);
// for(long i=0, j=3; i<4; i++, j--){
// long rkmer=rkmer1|i;
// long kmer=kmer1|(j<<shift2);
// long key=toValue(kmer, rkmer);
// int way=tables.kmerToWay(key);
// HashArray1D table=(HashArray1D) tables.tables()[way];
// int count=table.getValue(key);
// if(count>0 && count<=maxCount && table.getOwner(key)<=STATUS_UNEXPLORED){
// kmersTestedT++;
// boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts,
// minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true,
// countMatrixT, removeMatrixT);
// if(b){sum++;}
// }
// }
// }
// return sum;
// }
//new
private int processKmer_high_safe(final long key0){
int sum=0;
final long kmer0=key0;
final long rkmer0=AminoAcid.reverseComplementBinaryFast(key0, k);
sum+=processKmer_high_safe_leftLoop(kmer0, rkmer0);
sum+=processKmer_high_safe_leftLoop(rkmer0, kmer0);
return sum;
}
private int processKmer_high_safe_leftLoop(final long kmer0, final long rkmer0){
int sum=0;
final long kmer1=(kmer0<<2)&mask;
final long rkmer1=(rkmer0>>2);
for(long i=0, j=3; i<4; i++, j--){
final long kmer=kmer1|i;
final long rkmer=rkmer1|(j<<shift2);
final long key=toValue(kmer, rkmer);
final int way=tables.kmerToWay(key);
HashArray1D table=(HashArray1D) tables.tables()[way];
final int count=table.getValue(key);
if(count>0 && count<=maxCount && table.getOwner(key)<=STATUS_UNEXPLORED){
kmersTestedT++;
boolean b=exploreAndMark(key, builderT, leftCounts, rightCounts,
minCount, maxCount, maxLengthToDiscard, maxDistanceToExplore, true,
countMatrixT, removeMatrixT);
if(b){sum++;}
}
}
return sum;
}
final int shift;
final int shift2;
final long mask;
}
/*--------------------------------------------------------------*/
/*---------------- ShaveThread ----------------*/
/*--------------------------------------------------------------*/
/**
* Removes dead-end kmers.
*/
class ShaveThread extends AbstractShaveThread{
/**
* Constructor
*/
public ShaveThread(int id_){
super(id_);
}
@Override
boolean processNextTable(){
final int tnum=nextTable.getAndAdd(1);
if(tnum>=tables.ways){return false;}
// long x=0;
final HashArray1D table=tables.getTable(tnum);
final AtomicIntegerArray owners=table.owners();
final int[] values=table.values();
final int max=table.arrayLength();
for(int cell=0; cell<max; cell++){
if(owners.get(cell)==STATUS_REMOVE){
// x++;
values[cell]=0;
}
}
for(KmerNode kn : table.victims().array()){
if(kn!=null){traverseKmerNode(kn);}
}
table.clearOwnership();
kmersRemovedT+=table.regenerate(0);
// outstream.println(x);
return true;
}
private void traverseKmerNode(KmerNode kn){
if(kn==null){return;}
if(kn.owner()==STATUS_REMOVE){kn.set(0);}
traverseKmerNode(kn.left());
traverseKmerNode(kn.right());
}
}
/*--------------------------------------------------------------*/
/*---------------- Recall Methods ----------------*/
/*--------------------------------------------------------------*/
private final long toValue(long kmer, long rkmer){return tables.toValue(kmer, rkmer);}
int getCount(long kmer, long rkmer){return tables.getCount(kmer, rkmer);}
boolean claim(long kmer, int id){return claim(kmer, AminoAcid.reverseComplementBinaryFast(kmer, k), id);}
boolean claim(long kmer, long rkmer, int id){return tables.claim(kmer, rkmer, id);}
boolean doubleClaim(ByteBuilder bb, int id/*, long rid*/){return tables.doubleClaim(bb, id/*, rid*/);}
boolean claim(ByteBuilder bb, int id, /*long rid, */boolean earlyExit){return tables.claim(bb, id/*, rid*/, earlyExit);}
boolean claim(byte[] array, int len, int id, /*long rid, */boolean earlyExit){return tables.claim(array, len, id/*, rid*/, earlyExit);}
int findOwner(long kmer){return tables.findOwner(kmer);}
int findOwner(ByteBuilder bb, int id){return tables.findOwner(bb, id);}
int findOwner(byte[] array, int len, int id){return tables.findOwner(array, len, id);}
void release(ByteBuilder bb, int id){tables.release(bb, id);}
void release(byte[] array, int len, int id){tables.release(array, len, id);}
int fillRightCounts(long kmer, long rkmer, int[] counts, long mask, int shift2){return tables.fillRightCounts(kmer, rkmer, counts, mask, shift2);}
int fillLeftCounts(long kmer, long rkmer, int[] counts, long mask, int shift2){return tables.fillLeftCounts(kmer, rkmer, counts, mask, shift2);}
static StringBuilder toText(long kmer, int k){return AbstractKmerTable.toText(kmer, k);}
/*--------------------------------------------------------------*/
/*---------------- Fields ----------------*/
/*--------------------------------------------------------------*/
/*--------------------------------------------------------------*/
/*---------------- Final Fields ----------------*/
/*--------------------------------------------------------------*/
@Override
AbstractKmerTableSet tables(){return tables;}
final KmerTableSet tables;
final int k;
}
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