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package cardinality;
import java.io.File;
import java.io.PrintStream;
import java.util.ArrayList;
import java.util.Random;
import dna.AminoAcid;
import fileIO.FileFormat;
import fileIO.ReadWrite;
import shared.Parse;
import shared.Parser;
import shared.Shared;
import shared.Timer;
import shared.Tools;
import stream.ConcurrentGenericReadInputStream;
import stream.ConcurrentReadInputStream;
import stream.FastaReadInputStream;
import stream.Read;
import structures.ListNum;
import structures.LongList;
import tracker.ReadStats;
class LogLogWrapper {
public static final void main(String[] args){
LogLogWrapper llw=new LogLogWrapper(args);
final boolean vic=Read.VALIDATE_IN_CONSTRUCTOR;
Read.VALIDATE_IN_CONSTRUCTOR=Shared.threads()<4;
Timer t=new Timer();
LongList results=new LongList();
for(int i=0; i<llw.trials; i++){
long card=llw.process();
results.add(card);
}
if(llw.trials>1){
results.sort();
long kmers=llw.kmersProcessed;
double mean=results.mean();
double hmean=results.harmonicMean();
double gmean=results.geometricMean();
final double div=hmean;
// long expected=(150-31+1)*llw.maxReads;
// if(!llw.synth){expected=(long)mean;}
long median=results.median();
long min=results.min();
long max=results.max();
long p05=results.percentile(0.05);
long p95=results.percentile(0.95);
double stdev=results.stdev();
double avgDif=results.avgDif(mean);
// double rmsDif=results.rmsDif(mean);
double range=(p95-p05)/div;
// System.err.println(stdev);
// System.err.println(rmsDif);
stdev=stdev/div;
avgDif=avgDif/div;
// rmsDif=rmsDif/mean;
/* Testing indicates that more buckets and fewer trials is more accurate. */
/* For example, 8 buckets 256 trials < 32 buckets 64 trials < 256 buckets 8 trials, */
/* from the standpoint of minimizing the standard deviation of the hmean of the estimates over 45 reps. */
t.stopAndPrint();
System.err.println("#Trials\tkmers\thmean\tmedian\tmin\tmax\t5%ile\t95%ile\trange\tstdev\tavgDif");
System.err.println(llw.trials+"\t"+kmers+"\t"+String.format("%.2f", hmean)+"\t"+median+"\t"+min+"\t"+max
+"\t"+p05+"\t"+p95+"\t"+String.format("%.5f", range)+"\t"+String.format("%.5f", stdev)+"\t"+String.format("%.5f", avgDif));
if(CardinalityTracker.trackCounts){
System.err.println("Avg Count:\t"+String.format("%.4f", llw.countSum/(llw.trials*(double)llw.buckets)));
}
// System.err.println("#Trials\tkmers\tmean\thmean\tgmean\tmedian\tmin\tmax\t5%ile\t95%ile\trange\tstdev\tavgDif");
// System.err.println(llw.trials+"\t"+kmers+"\t"+String.format("%.2f", mean)+"\t"+String.format("%.2f", hmean)+"\t"+String.format("%.2f", gmean)+"\t"+median+"\t"+min+"\t"+max
// +"\t"+p05+"\t"+p95+"\t"+String.format("%.5f", range)+"\t"+String.format("%.5f", stdev)+"\t"+String.format("%.5f", avgDif));
}
Read.VALIDATE_IN_CONSTRUCTOR=vic;
}
public LogLogWrapper(String[] args){
Shared.capBufferLen(200);
Shared.capBuffers(8);
ReadWrite.USE_PIGZ=ReadWrite.USE_UNPIGZ=true;
ReadWrite.setZipThreads(Shared.threads());
Parser parser=new Parser();
for(int i=0; i<args.length; i++){
String arg=args[i];
String[] split=arg.split("=");
String a=split[0].toLowerCase();
String b=split.length>1 ? split[1] : null;
if(a.equals("buckets") || a.equals("loglogbuckets")){
buckets=Parse.parseIntKMG(b);
}else if(a.equals("k") || a.equals("loglogk")){
k=Integer.parseInt(b);
}else if(a.equals("seed") || a.equals("loglogseed")){
seed=Long.parseLong(b);
}else if(a.equals("seed2")){
seed2=Long.parseLong(b);
}else if(a.equals("minprob") || a.equals("loglogminprob")){
minProb=Float.parseFloat(b);
}else if(a.equals("synth")){
synth=Parse.parseBoolean(b);
}else if(a.equals("trials")){
trials=Parse.parseIntKMG(b);
}else if(a.equals("verbose")){
verbose=Parse.parseBoolean(b);
}else if(a.equals("loglogcounts") || a.equals("loglogcount") ||
a.equals("count") || a.equals("counts") || a.equals("trackcounts")){
CardinalityTracker.trackCounts=Parse.parseBoolean(b);
}else if(a.equals("atomic")){
assert(false) : "Atomic flag disabled.";
// CardinalityTracker.atomic=Parse.parseBoolean(b);
}else if(parser.parse(arg, a, b)){
//do nothing
}else if(a.equals("parse_flag_goes_here")){
//Set a variable here
}else if(in1==null && i==0 && Tools.looksLikeInputStream(arg)){
parser.in1=b;
}
else{
outstream.println("Unknown parameter "+args[i]);
assert(false) : "Unknown parameter "+args[i];
// throw new RuntimeException("Unknown parameter "+args[i]);
}
}
{//Process parser fields
Parser.processQuality();
maxReads=parser.maxReads;
overwrite=ReadStats.overwrite=parser.overwrite;
append=ReadStats.append=parser.append;
in1=(parser.in1==null ? null : parser.in1.split(","));
in2=(parser.in2==null ? null : parser.in2.split(","));
out=parser.out1;
}
assert(synth || (in1!=null && in1.length>0)) : "No primary input file specified.";
if(synth){
ffin1=ffin2=null;
}else{
ffin1=new FileFormat[in1.length];
ffin2=new FileFormat[in1.length];
for(int i=0; i<in1.length; i++){
String a=in1[i];
String b=(in2!=null && in2.length>i ? in2[i] : null);
assert(a!=null) : "Null input filename.";
if(b==null && a.indexOf('#')>-1 && !new File(a).exists()){
b=a.replace("#", "2");
a=a.replace("#", "1");
}
ffin1[i]=FileFormat.testInput(a, FileFormat.FASTQ, null, true, true);
ffin2[i]=FileFormat.testInput(b, FileFormat.FASTQ, null, true, true);
}
}
threads=Shared.threads();
assert(FastaReadInputStream.settingsOK());
}
long process(){
Timer t=new Timer();
readsProcessed=basesProcessed=kmersProcessed=0;
CardinalityTracker log=CardinalityTracker.makeTracker(buckets, k, seed, minProb);
for(int ffnum=0, max=(synth ? 1 : ffin1.length); ffnum<max; ffnum++){
ConcurrentReadInputStream cris=null;
if(!synth){
cris=ConcurrentGenericReadInputStream.getReadInputStream(maxReads, false, ffin1[ffnum], ffin2[ffnum]);
cris.start();
}
LogLogThread[] threadArray=new LogLogThread[threads];
for(int tid=0; tid<threadArray.length; tid++){
threadArray[tid]=new LogLogThread((CardinalityTracker.atomic ? log : CardinalityTracker.makeTracker(buckets, k, seed, minProb)), cris, tid);
}
for(LogLogThread llt : threadArray){
llt.start();
}
for(LogLogThread llt : threadArray){
while(llt.getState()!=Thread.State.TERMINATED){
try {
llt.join();
} catch (InterruptedException e) {
// TODO Auto-generated catch block
e.printStackTrace();
}
}
readsProcessed+=llt.readsProcessedT;
basesProcessed+=llt.basesProcessedT;
kmersProcessed+=llt.kmersProcessedT;
if(!CardinalityTracker.atomic){log.add(llt.log);}
}
if(cris!=null){errorState|=ReadWrite.closeStreams(cris);}
}
// final int[] max=new int[buckets];
// if(CardinalityTracker.atomic){
// for(int i=0; i<log.maxArray.length(); i++){
// // System.err.println(log.maxArray.get(i));
// max[i]=log.maxArray.get(i);
// }
// }
t.stop();
long cardinality=log.cardinality();
countSum+=(CardinalityTracker.trackCounts ? log.countSum() : 0);
if(out!=null){
ReadWrite.writeString(cardinality+"\n", out);
}
if(!Parser.silent) {
// Arrays.sort(copy);
// System.err.println("Median: "+copy[Tools.median(copy)]);
// System.err.println("Mean: "+Tools.mean(copy));
// System.err.println("Harmonic Mean: "+Tools.harmonicMean(copy));
System.err.println("Cardinality: "+cardinality);
// System.err.println("CardinalityH: "+log.cardinalityH());
// for(long i : log.counts){System.err.println(i);}
System.err.println("Time: \t"+t);
}
return cardinality;
}
private static Read makeRead(int len, Random randy, Read r){
if(r==null || r.bases==null || r.bases.length!=len){
r=new Read(null, null, 0);
r.bases=new byte[len];
}
byte[] bases=r.bases;
int pos=0;
final int basesPerRand=4;//Fewer calls to rand should be faster
for(int max=bases.length-(bases.length%basesPerRand); pos<max;){
int x=randy.nextInt()%prime;
for(int i=0; i<basesPerRand; i++){
int num=x&3;
byte b=AminoAcid.numberToBase[num];
bases[pos]=b;
pos++;
x>>=2;
}
}
for(; pos<bases.length; pos++){
int x=randy.nextInt()%prime;
int num=x&3;
byte b=AminoAcid.numberToBase[num];
bases[pos]=b;
}
return r;
}
/*--------------------------------------------------------------*/
/*---------------- Inner Classes ----------------*/
/*--------------------------------------------------------------*/
private class LogLogThread extends Thread{
LogLogThread(CardinalityTracker log_, ConcurrentReadInputStream cris_, int tid_){
log=log_;
cris=cris_;
tid=tid_;
}
@Override
public void run(){
if(cris!=null){runCris();}
else{runSynth();}
}
public void runCris(){
final int kt=k;
ListNum<Read> ln=cris.nextList();
ArrayList<Read> reads=(ln!=null ? ln.list : null);
while(ln!=null && reads!=null && reads.size()>0){//ln!=null prevents a compiler potential null access warning
for(Read r : reads){
// if(!r.validated()){r.validate(true);}
// if(r.mate!=null && !r.mate.validated()){r.mate.validate(true);}
log.hash(r);
readsProcessedT+=r.pairCount();
basesProcessedT+=r.pairLength();
kmersProcessedT+=r.numPairKmers(kt);
}
cris.returnList(ln);
ln=cris.nextList();
reads=(ln!=null ? ln.list : null);
}
cris.returnList(ln);
}
public void runSynth(){
final int kt=k;
assert(maxReads>0 && maxReads<Long.MAX_VALUE);
long readsLeft=maxReads/threads;
readsLeft+=(maxReads%threads>tid ? 1 : 0);
Random randy=Shared.threadLocalRandom(seed2<0 ? seed2 : seed2+999999L);
Read r=null;
while(readsLeft>0){
r=makeRead(150, randy, r);
log.hash(r);
readsProcessedT+=r.pairCount();
basesProcessedT+=r.pairLength();
kmersProcessedT+=r.numPairKmers(kt);
readsLeft--;
}
}
private final CardinalityTracker log;
private final ConcurrentReadInputStream cris;
private final int tid;
protected long readsProcessedT=0;
protected long basesProcessedT=0;
protected long kmersProcessedT=0;
}
/*--------------------------------------------------------------*/
/*---------------- Fields ----------------*/
/*--------------------------------------------------------------*/
private int buckets=2048;
private int k=31;
private long seed=-1;
private long seed2=-1;
private float minProb=0;
private long countSum=0;
private String[] in1=null;
private String[] in2=null;
private String out=null;
/*--------------------------------------------------------------*/
protected long readsProcessed=0;
protected long basesProcessed=0;
protected long kmersProcessed=0;
private long maxReads=-1;
boolean overwrite=true;
boolean append=false;
boolean errorState=false;
private int trials=1;
private boolean synth=false;
/*--------------------------------------------------------------*/
/*---------------- Final Fields ----------------*/
/*--------------------------------------------------------------*/
private final FileFormat[] ffin1;
private final FileFormat[] ffin2;
final int threads;
private static final int prime=32452843; //A prime number
/*--------------------------------------------------------------*/
/*---------------- Common Fields ----------------*/
/*--------------------------------------------------------------*/
private static PrintStream outstream=System.err;
public static boolean verbose=false;
}
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