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package cardinality;
import java.io.File;
import java.io.PrintStream;
import java.util.ArrayList;
import java.util.Arrays;
import java.util.Random;
import java.util.concurrent.atomic.AtomicIntegerArray;
import dna.AminoAcid;
import fileIO.FileFormat;
import fileIO.ReadWrite;
import jgi.Dedupe;
import shared.Parse;
import shared.Parser;
import shared.Primes;
import shared.Shared;
import shared.Timer;
import shared.Tools;
import stream.ConcurrentGenericReadInputStream;
import stream.ConcurrentReadInputStream;
import stream.FastaReadInputStream;
import stream.Read;
import structures.ListNum;
import tracker.ReadStats;
import ukmer.Kmer;
/**
* @author Brian Bushnell
* @date Sep 30, 2015
*
*/
public class LogLog_old {
/** Create a LogLog with default parameters */
public LogLog_old(){
this(1999, 8, 31, -1, 0);
}
/** Create a LogLog with parsed parameters */
public LogLog_old(Parser p){
this(p.loglogbuckets, p.loglogbits, p.loglogk, p.loglogseed, p.loglogMinprob);
}
/**
* Create a LogLog with specified parameters
* @param buckets_ Number of buckets (counters)
* @param bits_ Bits hashed per cycle
* @param k_ Kmer length
* @param seed Random number generator seed; -1 for a random seed
* @param minProb_ Ignore kmers with under this probability of being correct
*/
public LogLog_old(int buckets_, int bits_, int k_, long seed, float minProb_){
// hashes=hashes_;
// if((buckets_&1)==0){buckets_=(int)Primes.primeAtLeast(buckets_);}
buckets=buckets_;
assert(Integer.bitCount(buckets)==1) : "Buckets must be a power of 2: "+buckets;
bucketMask=buckets-1;
bits=bits_;
k=Kmer.getKbig(k_);
minProb=minProb_;
//assert(atomic);
maxArrayA=(atomic ? new AtomicIntegerArray(buckets) : null);
maxArray=(atomic ? null : new int[buckets]);
steps=(63+bits)/bits;
tables=new long[numTables][][];
for(int i=0; i<numTables; i++){
tables[i]=makeCodes(steps, bits, (seed<0 ? -1 : seed+i));
}
// assert(false) : "steps="+steps+", "+tables.length+", "+tables[0].length+", "+tables[0][0].length;
}
public static void main(String[] args){
LogLogWrapper llw=new LogLogWrapper(args);
final boolean vic=Read.VALIDATE_IN_CONSTRUCTOR;
Read.VALIDATE_IN_CONSTRUCTOR=Shared.threads()<4;
llw.process();
Read.VALIDATE_IN_CONSTRUCTOR=vic;
}
// public final long cardinality(boolean weighted){
// double mult=0.7947388;
// if(weighted){mult=0.7600300;}
// return cardinality(mult);
// }
public final long cardinality(){
return cardinality(0.7947388);
}
public final long cardinality(double mult){
long sum=0;
//assert(atomic);
if(atomic){
for(int i=0; i<maxArrayA.length(); i++){
sum+=maxArrayA.get(i);
}
}else{
for(int i=0; i<maxArray.length; i++){
sum+=maxArray[i];
}
}
double mean=sum/(double)buckets;
long cardinality=(long)((((Math.pow(2, mean)-1)*buckets*SKIPMOD))/1.258275);
lastCardinality=cardinality;
return cardinality;
}
public final long cardinalityH(){
double sum=0;
for(int i=0; i<maxArrayA.length(); i++){
int x=Tools.max(1, maxArrayA.get(i));
sum+=1.0/x;
}
double mean=buckets/sum;
return (long)((Math.pow(2, mean)*buckets*SKIPMOD));
}
// public long hashOld(final long value0, final long[][] table){
// long value=value0, code=value0;
// long mask=(bits>63 ? -1L : ~((-1L)<<bits));
//
// for(int i=0; i<steps; i++){
// int x=(int)(value&mask);
// value>>=bits;
// code=Long.rotateLeft(code^table[i][x], 3);
// }
// return Long.rotateLeft(code, (int)(value0&31));
// }
public long hash(final long value0, final long[][] table){
long value=value0, code=0;
long mask=(bits>63 ? -1L : ~((-1L)<<bits));
for(int i=0; i<steps; i++){//I could also do while value!=0
int x=(int)(value&mask);
value>>=bits;
code=code^table[i][x];
}
return code;
}
public void add(long number){
hash(number);
}
public void hash(Read r){
if(r==null){return;}
if(r.length()>=k){hash(r.bases, r.quality);}
if(r.mateLength()>=k){hash(r.mate.bases, r.mate.quality);}
}
public void hash(byte[] bases, byte[] quals){
if(k<32){hashSmall(bases, quals);}
else{hashBig(bases, quals);}
}
public void hashSmall(byte[] bases, byte[] quals){
final int shift=2*k;
final int shift2=shift-2;
final long mask=(shift>63 ? -1L : ~((-1L)<<shift));
int len=0;
long kmer=0, rkmer=0;
if(minProb>0 && quals!=null){//Debranched loop
assert(quals.length==bases.length) : quals.length+", "+bases.length;
float prob=1;
for(int i=0; i<bases.length; i++){
byte b=bases[i];
long x=AminoAcid.baseToNumber[b];
long x2=AminoAcid.baseToComplementNumber[b];
kmer=((kmer<<2)|x)&mask;
rkmer=((rkmer>>>2)|(x2<<shift2))&mask;
{//Update probability
byte q=quals[i];
prob=prob*PROB_CORRECT[q];
if(len>k){
byte oldq=quals[i-k];
prob=prob*PROB_CORRECT_INVERSE[oldq];
}
}
if(x>=0){
len++;
}else{
len=0;
kmer=rkmer=0;
prob=1;
}
if(len>=k && prob>=minProb){
add(Tools.max(kmer, rkmer));
}
}
}else{
for(int i=0; i<bases.length; i++){
byte b=bases[i];
long x=AminoAcid.baseToNumber[b];
long x2=AminoAcid.baseToComplementNumber[b];
kmer=((kmer<<2)|x)&mask;
rkmer=((rkmer>>>2)|(x2<<shift2))&mask;
if(x>=0){
len++;
}else{
len=0;
kmer=rkmer=0;
}
if(len>=k){
add(Tools.max(kmer, rkmer));
}
}
}
}
public void hashBig(byte[] bases, byte[] quals){
Kmer kmer=getLocalKmer();
int len=0;
float prob=1;
for(int i=0; i<bases.length; i++){
byte b=bases[i];
long x=Dedupe.baseToNumber[b];
kmer.addRightNumeric(x);
if(minProb>0 && quals!=null){//Update probability
prob=prob*PROB_CORRECT[quals[i]];
if(len>k){
byte oldq=quals[i-k];
prob=prob*PROB_CORRECT_INVERSE[oldq];
}
}
if(AminoAcid.isFullyDefined(b)){
len++;
}else{
len=0;
prob=1;
}
if(len>=k && prob>=minProb){
add(kmer.xor());
}
}
}
public void add(LogLog_old log){
if(atomic && maxArrayA!=log.maxArrayA){
for(int i=0; i<buckets; i++){
maxArrayA.set(maxArrayA.get(i), log.maxArrayA.get(i));
}
}else{
for(int i=0; i<buckets; i++){
maxArray[i]=Tools.max(maxArray[i], log.maxArray[i]);
}
}
}
public void hash(final long number){
if(number%SKIPMOD!=0){return;}
long key=number;
// int i=(int)(number%5);
// key=Long.rotateRight(key, 1);
// key=hash(key, tables[i%numTables]);
key=hash(key, tables[((int)number)&numTablesMask]);
int leading=Long.numberOfLeadingZeros(key);
// counts[leading]++;
if(leading<3){return;}
// final int bucket=(int)((number&Integer.MAX_VALUE)%buckets);
final int bucket=(int)(key&bucketMask);
if(atomic){
int x=maxArrayA.get(bucket);
while(leading>x){
boolean b=maxArrayA.compareAndSet(bucket, x, leading);
if(b){x=leading;}
else{x=maxArrayA.get(bucket);}
}
}else{
maxArray[bucket]=Tools.max(leading, maxArray[bucket]);
}
}
private static long[][] makeCodes(int length, int bits, long seed){
Random randy=Shared.threadLocalRandom(seed);
int modes=1<<bits;
long[][] r=new long[length][modes];
for(int i=0; i<length; i++){
for(int j=0; j<modes; j++){
long x=randy.nextLong();
while(Long.bitCount(x)>33){
x&=(~(1L<<randy.nextInt(64)));
}
while(Long.bitCount(x)<31){
x|=(1L<<randy.nextInt(64));
}
r[i][j]=x;
}
}
return r;
}
public final int k;
public final int numTables=4;
public final int numTablesMask=numTables-1;
public final int bits;
public final float minProb;
// public final int hashes;
public final int steps;
private final long[][][] tables;
public final AtomicIntegerArray maxArrayA;
public final int[] maxArray;
public final int buckets;
public final int bucketMask;
private final ThreadLocal<Kmer> localKmer=new ThreadLocal<Kmer>();
protected Kmer getLocalKmer(){
Kmer kmer=localKmer.get();
if(kmer==null){
localKmer.set(new Kmer(k));
kmer=localKmer.get();
}
kmer.clearFast();
return kmer;
}
private static class LogLogWrapper{
public LogLogWrapper(String[] args){
Shared.capBufferLen(200);
Shared.capBuffers(8);
ReadWrite.USE_PIGZ=ReadWrite.USE_UNPIGZ=true;
ReadWrite.setZipThreads(Shared.threads());
Parser parser=new Parser();
for(int i=0; i<args.length; i++){
String arg=args[i];
String[] split=arg.split("=");
String a=split[0].toLowerCase();
String b=split.length>1 ? split[1] : null;
if(parser.parse(arg, a, b)){
//do nothing
}else if(a.equals("buckets") || a.equals("loglogbuckets")){
long x=Parse.parseKMG(b);
buckets=(int)Primes.primeAtLeast(Tools.min(1000000, x));
}else if(a.equals("bits") || a.equals("loglogbits")){
bits=Integer.parseInt(b);
}else if(a.equals("k") || a.equals("loglogk")){
k=Integer.parseInt(b);
}else if(a.equals("seed") || a.equals("loglogseed")){
seed=Long.parseLong(b);
}else if(a.equals("minprob") || a.equals("loglogminprob")){
minProb=Float.parseFloat(b);
}else if(a.equals("verbose")){
verbose=Parse.parseBoolean(b);
}else if(a.equals("atomic")){
assert(false) : "Atomic flag disabled.";
// atomic=Parse.parseBoolean(b);
}else if(a.equals("parse_flag_goes_here")){
//Set a variable here
}else if(in1==null && i==0 && Tools.looksLikeInputStream(arg)){
parser.in1=b;
}else{
outstream.println("Unknown parameter "+args[i]);
assert(false) : "Unknown parameter "+args[i];
// throw new RuntimeException("Unknown parameter "+args[i]);
}
}
{//Process parser fields
Parser.processQuality();
maxReads=parser.maxReads;
overwrite=ReadStats.overwrite=parser.overwrite;
append=ReadStats.append=parser.append;
in1=(parser.in1==null ? null : parser.in1.split(","));
in2=(parser.in2==null ? null : parser.in2.split(","));
out=parser.out1;
}
assert(in1!=null && in1.length>0) : "No primary input file specified.";
{
ffin1=new FileFormat[in1.length];
ffin2=new FileFormat[in1.length];
for(int i=0; i<in1.length; i++){
String a=in1[i];
String b=(in2!=null && in2.length>i ? in2[i] : null);
assert(a!=null) : "Null input filename.";
if(b==null && a.indexOf('#')>-1 && !new File(a).exists()){
b=a.replace("#", "2");
a=a.replace("#", "1");
}
ffin1[i]=FileFormat.testInput(a, FileFormat.FASTQ, null, true, true);
ffin2[i]=FileFormat.testInput(b, FileFormat.FASTQ, null, true, true);
}
}
assert(FastaReadInputStream.settingsOK());
}
void process(){
Timer t=new Timer();
LogLog_old log=new LogLog_old(buckets, bits, k, seed, minProb);
for(int ffnum=0; ffnum<ffin1.length; ffnum++){
ConcurrentReadInputStream cris=ConcurrentGenericReadInputStream.getReadInputStream(maxReads, false, ffin1[ffnum], ffin2[ffnum]);
cris.start();
LogLogThread[] threads=new LogLogThread[Shared.threads()];
for(int i=0; i<threads.length; i++){
threads[i]=new LogLogThread((atomic ? log : new LogLog_old(buckets, bits, k, seed, minProb)), cris);
}
for(LogLogThread llt : threads){
llt.start();
}
for(LogLogThread llt : threads){
while(llt.getState()!=Thread.State.TERMINATED){
try {
llt.join();
} catch (InterruptedException e) {
// TODO Auto-generated catch block
e.printStackTrace();
}
}
if(!atomic){log.add(llt.log);}
}
errorState|=ReadWrite.closeStreams(cris);
}
final int[] max=new int[buckets];
if(atomic){
for(int i=0; i<log.maxArrayA.length(); i++){
// System.err.println(log.maxArray.get(i));
max[i]=log.maxArrayA.get(i);
}
}
t.stop();
long cardinality=log.cardinality();
if(out!=null){
ReadWrite.writeString(cardinality+"\n", out);
}
// Arrays.sort(copy);
// System.err.println("Median: "+copy[Tools.median(copy)]);
// System.err.println("Mean: "+Tools.mean(copy));
// System.err.println("Harmonic Mean: "+Tools.harmonicMean(copy));
System.err.println("Cardinality: "+log.cardinality());
// System.err.println("CardinalityH: "+log.cardinalityH());
// for(long i : log.counts){System.err.println(i);}
System.err.println("Time: \t"+t);
}
private class LogLogThread extends Thread{
LogLogThread(LogLog_old log_, ConcurrentReadInputStream cris_){
log=log_;
cris=cris_;
}
@Override
public void run(){
ListNum<Read> ln=cris.nextList();
ArrayList<Read> reads=(ln!=null ? ln.list : null);
while(ln!=null && reads!=null && reads.size()>0){//ln!=null prevents a compiler potential null access warning
for(Read r : reads){
// if(!r.validated()){r.validate(true);}
// if(r.mate!=null && !r.mate.validated()){r.mate.validate(true);}
log.hash(r);
}
cris.returnList(ln);
ln=cris.nextList();
reads=(ln!=null ? ln.list : null);
}
cris.returnList(ln);
}
private final LogLog_old log;
private final ConcurrentReadInputStream cris;
}
/*--------------------------------------------------------------*/
/*---------------- Fields ----------------*/
/*--------------------------------------------------------------*/
private int buckets=2048;//1999
private int bits=8;
private int k=31;
private long seed=-1;
private float minProb=0;
private String[] in1=null;
private String[] in2=null;
private String out=null;
/*--------------------------------------------------------------*/
protected long readsProcessed=0;
protected long basesProcessed=0;
private long maxReads=-1;
boolean overwrite=true;
boolean append=false;
boolean errorState=false;
/*--------------------------------------------------------------*/
/*---------------- Final Fields ----------------*/
/*--------------------------------------------------------------*/
private final FileFormat[] ffin1;
private final FileFormat[] ffin2;
/*--------------------------------------------------------------*/
/*---------------- Common Fields ----------------*/
/*--------------------------------------------------------------*/
}
public static final float[] PROB_CORRECT=Arrays.copyOf(align2.QualityTools.PROB_CORRECT, 128);
public static final float[] PROB_CORRECT_INVERSE=Arrays.copyOf(align2.QualityTools.PROB_CORRECT_INVERSE, 128);
private static PrintStream outstream=System.err;
public static boolean verbose=false;
public static final boolean atomic=true;
private static final long SKIPMOD=3;
public static long lastCardinality=-1;
}
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