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package cluster;
import java.util.concurrent.atomic.AtomicLong;
import java.util.concurrent.atomic.AtomicLongArray;
import stream.Read;
/**
* @author Brian Bushnell
* @date Mar 24, 2014
*
*/
public class Cluster{
public Cluster(int id_, int k1_, int k2_, int arraylen1_, int arraylen2_){
id=id_;
k1=k1_;
k2=k2_;
arraylen1=arraylen1_;
arraylen2=arraylen2_;
kmerArray1=new AtomicLongArray(arraylen1);
kmerProbArray1=new float[arraylen1];
kmerArray2=new AtomicLongArray(arraylen2);
kmerProbArray2=new float[arraylen2];
}
/*--------------------------------------------------------------*/
public void recalculate(){
gc=(float)(gcCount.doubleValue()/baseCount.doubleValue());
if(k1>0){
long kmerCount=0;
for(int i=0; i<arraylen1; i++){
kmerCount+=kmerArray1.get(i);
}
double extra=(0.05/arraylen1);
double mult=(0.95/kmerCount);
for(int i=0; i<arraylen1; i++){
kmerProbArray1[i]=(float)(kmerArray1.get(i)*mult+extra);
}
}
if(k2>0){
long kmerCount=0;
for(int i=0; i<arraylen2; i++){
kmerCount+=kmerArray2.get(i);
}
double extra=(0.05/arraylen2);
double mult=(0.95/kmerCount);
for(int i=0; i<arraylen2; i++){
kmerProbArray2[i]=(float)(kmerArray2.get(i)*mult+extra);
}
}
}
public void resetAtomics(){
for(int i=0; i<arraylen1; i++){
kmerArray1.set(i, 0);
}
for(int i=0; i<arraylen2; i++){
kmerArray2.set(i, 0);
}
depthsum1.set(0);
depthsum2.set(0);
readCount.set(0);
baseCount.set(0);
gcCount.set(0);
}
public void add(Read r){
if(r==null){return;}
ReadTag rt=(ReadTag)r.obj;
assert(rt!=null);
final byte[] bases=r.bases;
readCount.incrementAndGet();
baseCount.addAndGet(bases.length);
gcCount.addAndGet(rt.gcCount);
if(rt.strand==0){
depthsum1.addAndGet(rt.depth);
}else{
depthsum2.addAndGet(rt.depth);
}
if(k1>0){
int[] kmers=rt.kmerArray1(k1);
int kmer=-1, run=0;
for(int i=0; i<kmers.length; i++){
int x=kmers[i];
if(x==kmer){
run++;
}else{
if(run>0){kmerArray1.addAndGet(kmer, run);}
kmer=x;
run=1;
}
}
if(run>0){kmerArray1.addAndGet(kmer, run);}
}
if(k2>0){
int[] kmers=rt.kmerArray2(k2);
for(int kmer=0; kmer<kmers.length; kmer++){
int x=kmers[kmer];
if(x>0){kmerArray2.addAndGet(kmer, x);}
}
}
}
public float score(Read r) {
if(r==null){return 0;}
return r.mate==null ? scoreSingle(r) : scorePaired(r);
}
public float scoreSingle(Read r) {
if(r==null){return 0;}
ReadTag rt=(ReadTag)r.obj;
assert(false) : "TODO";
float depthScore=scoreDepthSingle(rt);
float gcScore=scoreGcSingle(rt);
float kmerScore=scoreKmer1(rt);
assert(false);
float depthWeight=.2f;
float gcWeight=.2f;
float kmerWeight=.6f;
return depthWeight*depthScore+gcWeight*gcScore+kmerWeight*kmerScore;
}
/**
* @param rt
* @return
*/
private float scoreKmer1(ReadTag rt) {
int[] kmers=rt.kmerArray1(k1);
float score=0;
if(scoreMode1==SCORE_MODE_AND){
float f=ClusterTools.andCount(kmers, kmerArray1);
assert(false);
}else if(scoreMode1==SCORE_MODE_MULT){
float f=ClusterTools.innerProduct(kmers, kmerProbArray1);
assert(false);
}else{
throw new RuntimeException(""+scoreMode1);
}
return score;
}
/**
* @param rt
* @return
*/
private float scoreKmer2(ReadTag rt) {
int[] kmers=rt.kmerArray2(k2);
float[] probs=rt.kmerFreq2(k2);
float score=0;
if(scoreMode2==SCORE_MODE_AND){
float f=ClusterTools.andCount(kmers, kmerArray2);
assert(false);
}else if(scoreMode2==SCORE_MODE_MULT){
float f=ClusterTools.innerProduct(kmers, kmerProbArray2);
assert(false);
}else if(scoreMode2==SCORE_MODE_DIF){
float f=ClusterTools.absDif(probs, kmerProbArray2);
assert(false);
}else if(scoreMode2==SCORE_MODE_RMS){
float f=ClusterTools.rmsDif(probs, kmerProbArray2);
assert(false);
}else if(scoreMode2==SCORE_MODE_KS){
float f=ClusterTools.ksFunction(probs, kmerProbArray2);
assert(false);
}else{
throw new RuntimeException(""+scoreMode2);
}
return score;
}
/**
* @param rt
* @return
*/
private float scoreGcSingle(ReadTag rt) {
assert(false) : "TODO";
// TODO Auto-generated method stub
return 0;
}
/**
* @param rt
* @return
*/
private float scoreDepthSingle(ReadTag rt) {
assert(false) : "TODO";
// TODO Auto-generated method stub
return 0;
}
public float scorePaired(Read r) {
assert(false) : "TODO";
if(r==null){return 0;}
ReadTag rt=(ReadTag)r.obj;
// ReadTag rt1=rt.r
return 0;
}
/*--------------------------------------------------------------*/
public final int id;
/** 'big' kmer */
public final int k1;
/** 'small' kmer */
public final int k2;
public final int arraylen1;
public final int arraylen2;
/*--------------------------------------------------------------*/
public float gc;
public int depth1, depth2;
final AtomicLongArray kmerArray1;
final float[] kmerProbArray1;
final AtomicLongArray kmerArray2;
final float[] kmerProbArray2;
final AtomicLong depthsum1=new AtomicLong(0);
final AtomicLong depthsum2=new AtomicLong(0);
final AtomicLong readCount=new AtomicLong(0);
final AtomicLong baseCount=new AtomicLong(0);
// final AtomicLong kmerCount=new AtomicLong(0);
final AtomicLong gcCount=new AtomicLong(0);
/*--------------------------------------------------------------*/
public static final int SCORE_MODE_DIF=0;
public static final int SCORE_MODE_RMS=1;
public static final int SCORE_MODE_AND=2;
public static final int SCORE_MODE_MULT=3;
public static final int SCORE_MODE_KS=4;
public static int scoreMode1=SCORE_MODE_MULT;
public static int scoreMode2=SCORE_MODE_RMS;
}
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