File: Motif.java

package info (click to toggle)
bbmap 39.20%2Bdfsg-3
  • links: PTS, VCS
  • area: main
  • in suites: forky, sid
  • size: 26,024 kB
  • sloc: java: 312,743; sh: 18,099; python: 5,247; ansic: 2,074; perl: 96; makefile: 39; xml: 38
file content (232 lines) | stat: -rwxr-xr-x 6,028 bytes parent folder | download | duplicates (4)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
package dna;

public abstract class Motif {
	
	public Motif(String name_, int length_, int center_){
		center=center_;
		length=length_;
		suffix=length-center-1;
		name=name_;
		
//		assert(center>=0 && center<length);
	}
	
	
	public final int countExact(String s){
		return countExact(s, 0, s.length());
	}
	
	
	public final int countExact(String s, int a, int b){
		return countExact(s.getBytes(), a, b);
	}
	
	
	public final int countExtended(String s){
		return countExtended(s, 0, s.length());
	}
	
	
	public final int countExtended(String s, int a, int b){
		return countExtended(s.getBytes(), a, b);
	}
	
	
	public final int countExact(byte[] source, int a, int b){
		
		int max=min(b, source.length-1)-length+1;
		
		int count=0;
		
		for(int i=a; i<=max; i++){
			if(matchesExactly(source, i)){count++;}
		}
		
		return count;
		
	}
	
	
	public final int countExtended(byte[] source, int a, int b){
		
		int max=min(b, source.length-1)-length+1;
		
		int count=0;
		
		for(int i=a; i<=max; i++){
			if(matchesExtended(source, i)){count++;}
		}
		
		return count;
		
	}
	
	
	public boolean matchesExactly(byte[] source, int a){
		throw new RuntimeException();
	}
	
	
	public boolean matchesExtended(byte[] source, int a){
		throw new RuntimeException();
	}
	
	public float normalize(double strength){
		return (float)strength;
	}
	
	
	public float matchStrength(byte[] source, int a){
		return(matchesExactly(source, a) ? 1 : 0);
	}
	
	
	public static final int minPos(float[] array){
		int pos=0;
		for(int i=1; i<array.length; i++){
			if(array[i]<array[pos]){pos=i;}
		}
		return pos;
	}
	
	
	public static final int maxPos(float[] array){
		int pos=0;
		for(int i=1; i<array.length; i++){
			if(array[i]>array[pos]){pos=i;}
		}
		return pos;
	}
	
	@Override
	public String toString(){
		return name+", "+length+", "+center;
	}
	

	public final String name;
	public String commonLetters;
	public final int center;
	public final int length;
	public final int suffix;
	

	static final int min(int x, int y){return x<y ? x : y;}
	static final int max(int x, int y){return x>y ? x : y;}
	static final float min(float x, float y){return x<y ? x : y;}
	static final float max(float x, float y){return x>y ? x : y;}
	
	static final byte[] numberToBase=AminoAcid.numberToBase;
	static final byte[] numberToBaseExtended=AminoAcid.numberToBaseExtended;
	static final byte[] baseToNumber=AminoAcid.baseToNumberACGTN;
	static final byte[] baseToNumberExtended=AminoAcid.baseToNumberExtended;
	
	static final float[] baseProb1={0.256614f, 0.226617f, 0.238012f, 0.278756f};
	
	//Within 200 of exon and gene ends only
	static final float[] baseProb2={
		0.076019f, 0.046405f, 0.071754f, 0.062437f, 0.067143f, 0.066057f, 0.020333f, 0.073085f,
		0.060553f, 0.054897f, 0.068741f, 0.053822f, 0.052896f, 0.059260f, 0.077188f, 0.089412f
	};
	
	//name: Overall Frequency MP3
	static final float[] baseProb3={
		0.027343f, 0.011857f, 0.018295f, 0.018524f, 0.015942f, 0.012337f, 0.003792f, 0.014333f,
		0.019988f, 0.015837f, 0.020411f, 0.015518f, 0.014382f, 0.011355f, 0.016466f, 0.020234f,
		0.014364f, 0.014299f, 0.022875f, 0.015605f, 0.018893f, 0.019412f, 0.006677f, 0.021076f,
		0.003629f, 0.005854f, 0.006783f, 0.004067f, 0.010491f, 0.018413f, 0.024257f, 0.019924f,
		0.018029f, 0.010640f, 0.019427f, 0.012458f, 0.015158f, 0.017025f, 0.006167f, 0.016547f,
		0.018098f, 0.016891f, 0.020042f, 0.013710f, 0.010580f, 0.010773f, 0.018026f, 0.014443f,
		0.016281f, 0.009609f, 0.011157f, 0.015849f, 0.017150f, 0.017284f, 0.003696f, 0.021130f,
		0.018839f, 0.016316f, 0.021506f, 0.020527f, 0.017442f, 0.018720f, 0.018440f, 0.034811f
	};
	
//	protected static final Hashtable<String, float[]> percentTable=makePercentTable();
//
//	private static final Hashtable<String, float[]> makePercentTable(){
//
//		String[] keys={
//				"Exon Stops MP3",
//		};
//
//		float[][] values={
//				{
//					0.00234f, 0.01071f, 0.02476f, 0.05155f, 0.08682f, 0.1453f, 0.22434f, 0.29615f, 0.36233f, 0.41034f,
//					0.46028f, 0.52224f, 0.58198f, 0.63879f, 0.68356f, 0.70622f, 0.7268f, 0.75131f, 0.77065f, 0.79546f,
//					0.82445f, 0.85279f, 0.86899f, 0.88287f, 0.89197f, 0.90166f, 0.91405f, 0.93129f, 0.94708f, 0.95521f,
//					0.96106f, 0.96293f, 0.9663f, 0.97242f, 0.97662f, 0.97866f, 0.98017f, 0.98242f, 0.98459f, 0.98703f,
//					0.98957f, 0.99064f, 0.99157f, 0.99286f, 0.9952f, 0.99721f, 0.99858f, 0.99914f, 0.99967f, 0.9999f, 0.99998f
//				},
//		};
//
//		Hashtable<String, float[]> r= new Hashtable<String, float[]>();
//		for(int i=0; i<keys.length; i++){
//			r.put(keys[i], values[i]);
//		}
//
//		return r;
//	}

	static final float[] invBaseProb1=invert(baseProb1);
	
	static final float[] invBaseProb2=invert(baseProb2);
	
	static final float[] invBaseProb3=invert(baseProb3);
	
	static final float[][] baseProbN={
		null,
		baseProb1,
		baseProb2,
		baseProb3
	};
	
	static final float[][] invBaseProbN={
		null,
		invBaseProb1,
		invBaseProb2,
		invBaseProb3
	};
	
	private static final float[] invert(float[] in){
		float[] out=new float[in.length];
		for(int i=0; i<in.length; i++){
			out[i]=1f/in[i];
		}
		return out;
	}
	
	protected float[] percentile;

	public abstract int numBases();
	
	public float percentile(float strength){
//		float[] array=percentiles[numBases()];
		
		if(percentile==null){
			throw new RuntimeException("Can't find percentile array for "+this);
		}
		
		float[] array=percentile;
		
		int index=(int)(strength*array.length);
		
//		System.out.print(" *** index = "+index+" -> "+array[index]+" -> "+array[index+1]+" *** ");
		
		if(index>=array.length-1){return 1;}
		
		float a, b;
		if(index==0){
			a=0;
			b=array[0];
		}else{
			a=array[index];
			b=array[index+1];
		}
		
		float ratio=strength-(index/((float)array.length));
		
		return ratio*b+(1-ratio)*a;
		
	}
	
}