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package structures;
import java.io.Serializable;
import java.util.ArrayList;
import java.util.Arrays;
import java.util.HashMap;
import fileIO.ByteFile;
import fileIO.FileFormat;
import fileIO.ReadWrite;
import shared.LineParser;
import shared.LineParser1;
import shared.Shared;
import shared.Tools;
public abstract class CoverageArray implements Serializable {
/**
*
*/
private static final long serialVersionUID = -7175422489330746676L;
public static final CoverageArray read(String fname){
if(!fname.contains(".ca")){
throw new RuntimeException();
// ca=new CoverageArray2();
// ca.load(new TsvCoverageFile(fname));
// return ca;
}
fname=ReadWrite.findFileExtension(fname);
// System.err.println("Found "+fname);
return ReadWrite.read(CoverageArray.class, fname, true);
// if(fname.endsWith(".ca2") || fname.contains(".ca2.")){return ReadWrite.read(CoverageArray2.class, fname);}
// else if(fname.endsWith(".ca") || fname.contains(".ca.")){return ReadWrite.read(CoverageArray1.class, fname);}
// else{return ReadWrite.read(CoverageArray.class, fname);}
}
public static final Class<? extends CoverageArray> getType(boolean atomic, boolean bits32){
if(atomic && bits32) {return CoverageArray3A.class;}
else if(!atomic && bits32) {return CoverageArray3.class;}
else if(atomic && !bits32) {return CoverageArray2A.class;}
else if(!atomic && !bits32) {return CoverageArray2.class;}
throw new RuntimeException("No type.");
}
public CoverageArray(int chrom, int len){
chromosome=chrom;
length=len;
}
/**
* @param loc
* @param amt
*/
public abstract void increment(int loc, int amt);
/**
* @param loc
*/
public abstract void increment(int loc);
public final void incrementRange(int min, int max){incrementRange(min, max, 1);}
public abstract void incrementRange(int min, int max, int amt);
public abstract void incrementRangeSynchronized(int min, int max, int amt);
public void incrementRanges(IntList ranges, int amt){
for(int i=0; i<ranges.size; i+=2){
int a=ranges.get(i), b=ranges.get(i+1);
incrementRange(a, b-1, 1);
}
}
public abstract void set(int loc, int val);
public abstract int get(int loc);
public abstract void resize(int newlen);
public final double[][] toGraph(int blocksize, int min, int max){
min=max(min, minIndex);
max=min(max, maxIndex);
int length=max-min;
ArrayList<double[]> list=new ArrayList<double[]>();
int block;
if(blocksize<=0){
// block=((array.length+62999)/63000);//For Excel
// block=((length+62999)/63000);//For Excel
block=((length+31499)/31500);//For Excel
}else{
block=blocksize;
}
block=max(block, 1);
int current=0;
double[] sum=new double[2];
for(int loc=min; loc<=max; loc++){
if(current==block){
for(int i=0; i<sum.length; i++){
sum[i]=sum[i]/current;
}
sum[0]=Math.round(sum[0]);
list.add(sum);
sum=new double[2];
current=0;
}
sum[0]+=loc;
sum[1]+=get(loc);
current++;
}
return list.toArray(new double[0][]);
}
public static final void print(double[][] data){
// data=stats.Smoother.weightedAveragePlank(data, 24);
assert(false) : "Smoother disabled in this code purely to reduce dependancies.";
StringBuilder sb=new StringBuilder(data.length*20);
for(double[] d : data){
sb.append(Tools.format("%d\t%.2f\n",(int)d[0],d[1]));
}
System.out.print(sb);
}
public static CoverageArray makeArray(int num, int size, Class<? extends CoverageArray> c){
if(c==CoverageArray2.class){
return new CoverageArray2(num, size);
}else if(c==CoverageArray3.class){
return new CoverageArray3(num, size);
}else if(c==CoverageArray2A.class){
return new CoverageArray2A(num, size);
}else if(c==CoverageArray3A.class){
return new CoverageArray3A(num, size);
}
throw new RuntimeException("Unhandled class: "+c);
}
//TODO: Was extremely slow due to string processing. Now, should be fast, but needs verification that LineParser change is correct.
//This has been modified to allow concise cov files missing fields in lines when they are expected to be the same (or +1).
public static HashMap<String, CoverageArray> loadDepth(FileFormat ffdepth, Class<? extends CoverageArray> c) {
ByteFile bf=ByteFile.makeByteFile(ffdepth);
HashMap<String, CoverageArray> map=new HashMap<String, CoverageArray>();
String prevName=null;
int prevPos=-1;
int prevDepth=0;//TODO: I don't really need the 'prev' variables.
CoverageArray prevArray=null;
LineParser lp=new LineParser1('\t');
for(byte[] line=bf.nextLine(); line!=null; line=bf.nextLine()){
if(line[0]!='#'){
// String[] split=Tools.tabPattern.split(new String(line));
// String name=split[0];
// int pos=Integer.parseInt(split[1]);
// int depth=Integer.parseInt(split[2]);
lp.set(line);
final String name=(Tools.startsWith(line, prevName) || lp.length(0)<1 ? prevName : lp.parseString(0));
final int pos=(lp.length(1)<1 ? prevPos+1 : lp.parseInt(1));
final int depth=(lp.length(2)<1 ? prevDepth : lp.parseInt(2));
CoverageArray current;
if(name.equals(prevName)){
current=prevArray;
}else{
assert(!map.containsKey(name)) : name; //Could do a lookup but should not be needed
current=makeArray(map.size()+1, 64, c);
map.put(name, current);
prevName=name;
prevArray=current;
}
if(depth>0){current.set(pos, depth);}
prevPos=pos;
prevDepth=depth;
}
}
return map;
}
public final int basesUnderAverageCoverage(final double avg, final int window){
if(underWindowAverage>-1) {return underWindowAverage;}
//Possibly this should be special-cased to give a real result or return length
if(length<window){return underWindowAverage=length;}
final int usedDif=maxIndex-minIndex;
if(usedDif<0) {return underWindowAverage=length;}
final long limit=(long)Math.ceil(window*avg);
long covSum=0;
int baseCount=0;
for(int i=0; i<window; i++){
covSum+=get(i);
}
boolean below=false;
int lastStop=-1, lastStart=0;
for(int a=0, b=window; b<length; a++, b++){
if(covSum>=limit){
if(below){//end range
baseCount=b-Tools.max(lastStop+1, lastStart);
lastStop=b-1;
below=false;
}
}else{
if(!below){//start range
lastStart=a;
below=true;
}
}
covSum-=get(a);
assert(covSum>=0);
covSum+=get(b);
}
if(below){//end range
baseCount=length()-Tools.max(lastStop, lastStart);
}
assert(baseCount>=0) : baseCount+", "+avg+", "+window;
return underWindowAverage=baseCount;
}
public final long sum() {
if(sum>=0) {return sum;}
sum=0;
final int usedDif=maxIndex-minIndex;
if(usedDif<0) {return sum;}
for(int i=minIndex; i<=maxIndex; i++) {sum+=get(i);}
return sum;
}
public final int covered(int minDepth) {
if(covered>=0) {return covered;}
calcSumAndCovered(minDepth);
return covered;
}
public final long calcSumAndCovered(int minDepth) {
if(sum>=0 && covered>=0) {return sum;}
sum=0;
covered=0;
final int usedDif=maxIndex-minIndex;
if(usedDif<0) {return sum;}
for(int i=minIndex; i<=maxIndex; i++) {
int d=get(i);
sum+=d;
covered+=(d>=minDepth ? 1 : 0);
}
return sum;
}
//Don't use devSum() here!
public final double standardDeviation(){
if(stdev>=0) {return stdev;}
int length=length();
if(length<2){return 0;}
final int usedDif=maxIndex-minIndex;
if(usedDif<0) {return stdev=0;}
long sum=sum();
double avg=sum/(double)length;
double sumdev2=0;
for(int i=minIndex; i<length; i++){
int x=get(i);
double dev=avg-x;
sumdev2+=(dev*dev);
}
return stdev=Math.sqrt(sumdev2/length);
}
public final double devSum(double globalMean){
if(devSum>=0) {return devSum;}
final int length=length();
int usedDif=maxIndex-minIndex;
if(usedDif<0) {return devSum=globalMean*globalMean*length;}
devSum=0;
if(length<1){return 0;}
for(int i=minIndex; i<length; i++){
int x=get(i);
double dev=globalMean-x;
devSum+=(dev*dev);
}
return devSum;
}
//Note that empty arrays have a median of zero and do not need sorting
//Also note that sorting will mess up minIndex and maxIndex
public final int median(){
if(median>=0) {return median;}
final int usedDif=maxIndex-minIndex;
if(usedDif<0) {return 0;}
Object o=toArray();
if(o.getClass()==int[].class) {
int[] array=(int[])o;
Shared.sort(array);
Tools.reverseInPlace(array);
median=array[array.length/2];
}else {
char[] array=(char[])o;
Arrays.sort(array);
Tools.reverseInPlace(array);
median=array[array.length/2];
}
//Change the range after sorting
minIndex=0;
maxIndex=minIndex+usedDif;
return median;
}
public abstract Object toArray();
@Override
public abstract String toString();
static final long min(long x, long y){return x<y ? x : y;}
static final long max(long x, long y){return x>y ? x : y;}
static final int min(int x, int y){return x<y ? x : y;}
static final int max(int x, int y){return x>y ? x : y;}
public int maxIndex=-1;
public int minIndex=Integer.MAX_VALUE;
private final int length;//Note: This is arbitrary if resizing is allowed, as used in old classes...
public int length(){return length;}
public abstract int arrayLength();
public void setUnderWindowAverage(int x) {underWindowAverage=x;}
public void setMedian(int x) {median=x;}
public void setCovered(int x) {covered=x;}
public void setSum(long x) {sum=x;}
public void setStdev(double x) {stdev=x;}
public void setDevSum(double x) {devSum=x;}
private int underWindowAverage=-1;
private int median=-1;
private int covered=-1;
private long sum=-1;
private double stdev=-1;
private double devSum=-1;
/** Optional */
public int chromosome;
private static boolean OVERFLOWED=false;
}
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