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package ukmer;
import java.util.Arrays;
import dna.AminoAcid;
import shared.Tools;
import structures.ByteBuilder;
/**
* @author Brian Bushnell
* @date Jul 9, 2015
*
*/
public class Kmer implements Cloneable {
public Kmer(Kmer o){
this(o.k, o.mult);
setFrom(o);
}
public Kmer(int kbig_){
this(getK(kbig_), getMult(kbig_));
}
@Override
public Kmer clone(){
return new Kmer(this);
}
public Kmer(int k_, int mult_){
k=k_;
mult=mult_;
maxindex=mult-1;
shift=2*k;
shift2=shift-2;
mask=(shift>63 ? -1L : ~((-1L)<<shift));
coreMask=toCoreMask(k);
kbig=k*mult;
array1=new long[mult];
array2=new long[mult];
key=null;
}
public static final long toCoreMask(int k){
// System.err.println(k+", "+MASK_CORE);
return MASK_CORE ? ((~((-1L)<<(2*k)))>>2)&~(3L) : -1L;
}
public static int getMult(int kbig){
final int mult=getMult0(kbig);
// assert(mult==getMult0(kbig*(mult/mult))) : mult+", "+getMult0(mult*(kbig/mult));
return mult;
}
public static int getKbig(int kbig){
int x=getMult(kbig)*getK(kbig);
assert(x<=kbig) : x+", "+kbig;
assert(kbig>31 || x==kbig);
return x;
}
private static int getMult0(int kbig){
// if(true){return 2;}//TODO: 123 //Enable to allow multi-word arrays for k<32
final int word=31;
final int mult1=(kbig+word-1)/word;
final int mult2=Tools.max(1, kbig/word);
if(mult1==mult2){return mult1;}
final int k1=Tools.min(word, kbig/mult1);
final int k2=Tools.min(word, kbig/mult2);
final int kbig1=k1*mult1;
final int kbig2=k2*mult2;
assert(kbig1<=kbig);
assert(kbig2<=kbig);
assert(mult2<=mult1);
// assert(false) : mult1+", "+mult2+", "+k1+", "+k2;
final int mult=kbig2>=kbig1 ? mult2 : mult1;
return mult;
}
public static int getK(int kbig){
int mult=getMult(kbig);
int x=kbig/mult;
assert(x*mult<=kbig) : x+", "+kbig;
assert(x<=31) : kbig+", "+mult+", "+x;
return x;
}
public Kmer setFrom(Kmer o){
for(int i=0; i<mult; i++){
array1[i]=o.array1[i];
array2[i]=o.array2[i];
len=o.len;
}
incarnation++;
return this;
}
public Kmer setFrom(long[] array){
for(int i=0; i<mult; i++){
array1[i]=array[i];
}
fillArray2();
incarnation++;
return this;
}
public void clear() {
len=0;
for(int i=0; i<mult; i++){
array1[i]=0;
array2[i]=0;
}
lastIncarnation=-1;
incarnation=0;
//incarnation++;
}
public void clearFast() {
len=0;
lastIncarnation=-1;
incarnation=0;
//incarnation++;
}
public boolean verify(boolean update){
// boolean b=verify();
// if(b){
// if(update){update();}
// b=verify();
// assert(len<kbig || incarnation==lastIncarnation);
// }
if(update){
update();
assert(len<kbig || incarnation==lastIncarnation) : "incarnation="+incarnation+", last="+lastIncarnation+", len="+len+", kbig="+kbig;
}
boolean b=verify();
return b;
}
private boolean verify(){
if(len<kbig){return true;}
for(int i=maxindex, j=0; j<mult; j++, i--){
long kmer=array1[i];
long rkmer=array2[j];
if(kmer!=AminoAcid.reverseComplementBinaryFast(rkmer, k)){
// assert(false) : Arrays.toString(array1);
return false;
}
}
assert(incarnation==lastIncarnation) : "incarnation="+incarnation+", last="+lastIncarnation+", len="+len+", kbig="+kbig;
return true;
}
public byte addRight(final byte b){
long x=AminoAcid.baseToNumber[b];
return AminoAcid.numberToBase[(int)addRightNumeric(x)];
}
public byte addRight(final char b){
long x=AminoAcid.baseToNumber[b];
return AminoAcid.numberToBase[(int)addRightNumeric(x)];
}
public byte addLeft(final byte b){
long x=AminoAcid.baseToNumber[b];
return AminoAcid.numberToBase[(int)addLeftNumeric(x)];
}
public long addRightNumeric(long x){
long x2;
if(x<0){
x=0;
x2=3;
len=0;
}else{
x2=AminoAcid.numberToComplement[(int)x];
len++;
}
for(int i=maxindex, j=0; j<mult; j++, i--){
long y=(array1[i]>>>shift2)&3L;
long y2=array2[j]&3L;
//Update kmers
array1[i]=((array1[i]<<2)|x)&mask;
array2[j]=((array2[j]>>>2)|(x2<<shift2))&mask;
x=y;
x2=y2;
}
incarnation++;
return x;
}
public long addLeftNumeric(long x){
assert(x>=0 && x<4) : x;
long x2=AminoAcid.numberToComplement[(int)x];
assert(x>=0);
assert(len>=kbig);
for(int i=0, j=maxindex; i<mult; i++, j--){
long y=array1[i]&3L;
long y2=(array2[j]>>>shift2)&3L;
//Update kmers
array1[i]=(array1[i]>>>2)|(x<<shift2);
array2[j]=((array2[j]<<2)|x2)&mask;
x=y;
x2=y2;
}
incarnation++;
return x;
}
public void fillArray2() {
for(int i=maxindex, j=0; j<mult; j++, i--){
array2[j]=AminoAcid.reverseComplementBinaryFast(array1[i], k);
}
len=kbig;
incarnation++;
}
@Override
public String toString(){
// update();
assert(verify(true));
ByteBuilder bb=new ByteBuilder();
for(int i=0; i<mult; i++){
bb.appendKmer(array1[i], k);
// bb.append(" ");
}
//// bb.append("~");
// for(int i=0; i<mult; i++){
// bb.appendKmer(array2[i], k);
//// bb.append(" ");
// }
return bb.toString();
}
public boolean equals(Kmer x){
if(xor()!=x.xor()){return false;}
return AbstractKmerTableU.equals(key(), x.key());
}
public boolean sameOrientation(Kmer x){
if(xor()!=x.xor()){return false;}
return Tools.equals(array1, array2);
}
public int compareTo(Kmer x){
return compare(key(), x.key());
}
public int compareTo(long[] key2){
assert(false);
return compare(key(), key2);
}
public static int compare(long[] key1, long[] key2){
// assert(false); //Why was this here?
return AbstractKmerTableU.compare(key1, key2);
}
public static boolean equals(long[] key1, long[] key2){
assert(false);
return AbstractKmerTableU.equals(key1, key2);
}
public long[] array1(){return array1;}
public long[] array2(){return array2;}
/** WARNING!
* Do not confuse this with xor()! */
public long[] key(){
update();
// assert(verify(false));
return key;
}
public boolean corePalindrome(){//TODO: This can be set as a flag from setKey0
update();
return corePalindrome;
}
private void setKey0(){
corePalindrome=false;
key=array1;
if(!rcomp){return;}
for(int i=0; i<mult; i++){
final long a=array1[i]&coreMask, b=array2[i]&coreMask;
if(a>b){return;}
else if(a<b){
key=array2;
return;
}
}
corePalindrome=true;
setKey0safe();
}
private void setKey0safe(){
key=array1;
for(int i=0; i<mult; i++){
final long a=array1[i], b=array2[i];
if(a>b){break;}
else if(a<b){
key=array2;
break;
}
}
}
public static long xor(long[] key, long coreMask){
long xor=key[0]&coreMask;
for(int i=1; i<key.length; i++){
xor=(Long.rotateLeft(xor, 25))^(key[i]&coreMask);
}
return xor&mask63;
}
/** WARNING!
* Do not confuse this with key()! */
public long xor(){
update();
return lastXor;
}
/**
* @param divisor
* @return This kmer's xor modulo the divisor
*/
public int mod(int divisor) {
int x=(int)(xor()%divisor);
// System.err.println(xor()+"%"+value+"="+x);
return x;
}
public void rcomp() {
long[] temp=array1;
array1=array2;
array2=temp;
}
private void update(){
if(verbose){System.err.println("update() - len="+len);}
assert(TESTMODE || len>=kbig) : len+", "+kbig+", "+array1[0];
if(incarnation==lastIncarnation){return;}
setKey0();
lastXor=xor0();
lastIncarnation=incarnation;
if(verbose){System.err.println("After update - kmer "+this+"; key="+Arrays.toString(key)+"; a1="+Arrays.toString(array1())+"; a2="+Arrays.toString(array2()));}
}
private long xor0(){
return xor(key, coreMask);
}
public String arraysToString() {
return "key="+Arrays.toString(key)+", a1="+Arrays.toString(array1)+", a2="+Arrays.toString(array2);
}
public final int gc(){
int gc=0;
for(long kmer : array1){
while(kmer>0){
long x=kmer&3;
kmer>>>=2;
if(x==1 || x==2){gc++;}
}
}
return gc;
}
static boolean rcomp=true;
private long lastXor=-1;
private long incarnation=0;
private long lastIncarnation=-1;
private boolean corePalindrome=false;
private long[] key=null;
private long[] array1;
private long[] array2;
public final int kbig;
public final int k;
final int mult, maxindex;
private final int shift;
private final int shift2;
private final long mask;
private final long coreMask;
public int len=0; //TODO: Make private; use getter.
public final int len(){return len;}
public static boolean MASK_CORE=false;
private static final long mask63=Long.MAX_VALUE;
private static final boolean TESTMODE=false; //123
private static final boolean verbose=false;
}
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