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package var2;
import java.util.ArrayList;
import java.util.HashMap;
import java.util.Set;
import fileIO.ByteFile;
import fileIO.FileFormat;
import shared.Parse;
import shared.Tools;
import stream.Read;
import stream.ReadInputStream;
import stream.SamLine;
public class ScafMap {
/*--------------------------------------------------------------*/
/*---------------- Construction ----------------*/
/*--------------------------------------------------------------*/
public ScafMap(){}
/*--------------------------------------------------------------*/
public static ScafMap loadSamHeader(String fname){return loadSamHeader(fname, null);}
public static ScafMap loadSamHeader(FileFormat ff){return loadSamHeader(ff, null);}
public static ScafMap loadSamHeader(String fname, ScafMap scafMap){
FileFormat ff=FileFormat.testInput(fname, FileFormat.SAM, null, false, false);
return loadSamHeader(ff, scafMap);
}
public static ScafMap loadSamHeader(FileFormat ff, ScafMap scafMap){
ByteFile bf=ByteFile.makeByteFile(ff);
if(scafMap==null){scafMap=new ScafMap();}
byte[] line=bf.nextLine();
while(line!=null && line.length>0){
//assert(false) : new String(line);
if(Tools.startsWith(line, "@SQ\t")){
scafMap.add(line);
}else if(line[0]!='@'){
break;
}
line=bf.nextLine();
}
bf.close();
return scafMap;
}
/*--------------------------------------------------------------*/
public static ScafMap loadVcfHeader(String fname){return loadVcfHeader(fname, null);}
public static ScafMap loadVcfHeader(FileFormat ff){return loadVcfHeader(ff, null);}
public static ScafMap loadVcfHeader(String fname, ScafMap scafMap){
FileFormat ff=FileFormat.testInput(fname, FileFormat.VCF, null, false, false);
return loadVcfHeader(ff, scafMap);
}
public static ScafMap loadVcfHeader(FileFormat ff, ScafMap scafMap){
ByteFile bf=ByteFile.makeByteFile(ff);
if(scafMap==null){scafMap=new ScafMap();}
byte[] line=bf.nextLine();
// System.err.println(new String(line));
// assert(line!=null) : bf.name();
// assert(line.length>0) : bf.name();
while(line!=null && line.length>0){
//assert(false) : new String(line);
if(Tools.startsWith(line, "##contig=<ID=")){
scafMap.addFromVcf(line);
}else if(line[0]!='#'){
break;
}
line=bf.nextLine();
// System.err.println(new String(line));
}
bf.close();
// assert(false);
return scafMap;
}
/*--------------------------------------------------------------*/
public static ScafMap loadReference(String fname, boolean makeDefault){return loadReference(fname, null, null, makeDefault);}
public static ScafMap loadReference(FileFormat ff, boolean makeDefault){return loadReference(ff, null, null, makeDefault);}
public static ScafMap loadReference(String fname, ScafMap scafMap, SamFilter samFilter, boolean makeDefault){
FileFormat ff=FileFormat.testInput(fname, FileFormat.FASTA, null, true, true);
return loadReference(ff, scafMap, samFilter, makeDefault);
}
public static ScafMap loadReference(FileFormat ff, ScafMap map, SamFilter samFilter, boolean makeDefault){
if(defaultScafMapFile!=null && defaultScafMapFile.equals(ff.name())){return defaultScafMap;}
ArrayList<Read> reads=ReadInputStream.toReads(ff, -1);
if(map==null){map=new ScafMap();}
for(Read r : reads){
if(samFilter==null || samFilter.passesFilter(r.id)){
map.addScaffold(r);
}
}
if(makeDefault){setDefaultScafMap(map, ff.name());}
return map;
}
public static ScafMap defaultScafMap(){return defaultScafMap;}
public static void setDefaultScafMap(ScafMap map, String fname){
SamLine.RNAME_AS_BYTES=false;
assert(fname==null || defaultScafMapFile==null || !fname.equals(defaultScafMapFile)) : fname;
defaultScafMap=map;
defaultScafMapFile=fname;
}
/*--------------------------------------------------------------*/
/*---------------- Inherited ----------------*/
/*--------------------------------------------------------------*/
public void clear(){
map.clear();
alt.clear();
list.clear();
}
public int size(){return list.size();}
// public boolean containsKey(String s){
// return getScaffold(s)!=null;
// }
public Set<String> keySet() {
return map.keySet();
}
public Set<String> altKeySet() {
return alt.keySet();
}
/*--------------------------------------------------------------*/
/*---------------- Adders ----------------*/
/*--------------------------------------------------------------*/
public Scaffold addScaffold(Read r){
Scaffold scaf=map.get(r.id);
if(scaf==null){
scaf=new Scaffold(r.id, size(), r.length());
add(scaf);
}
scaf.bases=r.bases;
assert(scaf.bases.length==scaf.length) : "Incorrect reference length: "+scaf.bases.length+", "+scaf.length+", "+scaf.name;
return scaf;
}
public Scaffold add(byte[] line){
Scaffold scaf=new Scaffold(line, size());
Scaffold old=map.get(scaf.name);
if(old!=null){return old;}
return add(scaf);
}
//##contig=<ID=Escherichia_coli,length=4639675>
public Scaffold addFromVcf(byte[] line){
int comma=Tools.indexOf(line, (byte)',');
String name=new String(line, 13, comma-13);
int length=Parse.parseInt(line, comma+8, line.length-1);
Scaffold scaf=new Scaffold(name, size(), length);
Scaffold old=map.get(scaf.name);
if(old!=null){return old;}
return add(scaf);
}
public Scaffold add(String s, int len){
Scaffold scaf=map.get(s);
if(scaf!=null){return scaf;}
scaf=new Scaffold(s, size(), len);
return add(scaf);
}
private Scaffold add(Scaffold scaf){
assert(!map.containsKey(scaf.name));
assert(size()==scaf.number);
list.add(scaf);
map.put(scaf.name, scaf);
String s=scaf.name;
if(TRIM_WHITESPACE_ALSO){
for(int i=0; i<s.length(); i++){
if(Character.isWhitespace(s.charAt(i))){
String s2=s.substring(0, i);
boolean b=alt.containsKey(s2);
assert(!b);
if(!b){
alt.put(s2, scaf);
}
break;
}
}
}
return scaf;
}
public void addCoverage(SamLine sl){
if(!sl.mapped()){return;}
Scaffold scaf=getScaffold(sl);
scaf.add(sl);
}
/*--------------------------------------------------------------*/
/*---------------- Getters ----------------*/
/*--------------------------------------------------------------*/
public int getNumber(String s){
Scaffold value=getScaffold(s);
return value==null ? -1 : value.number;
}
public String getName(int number){
return number>=size() ? null : list.get(number).name;
}
public int getLength(int number){
return number>=size() ? 0 : list.get(number).length;
}
public Scaffold getScaffold(int number){
return number>=size() ? null : list.get(number);
}
public Scaffold getScaffold(final String s){
Scaffold value=map.get(s);
if(value==null){value=alt.get(s);}
if(value==null && TRIM_WHITESPACE_ALSO){
int index=-1;
for(int i=0; i<s.length(); i++){
if(Character.isWhitespace(s.charAt(i))){
index=i;
break;
}
}
String sub=null;
if(index>0){
sub=s.substring(0, index);
value=alt.get(sub);
if(value==null){value=map.get(sub);}
}
assert(value!=null) : "Scaffold not present in reference: "+s+"\nwhitespace="+index+
"\nsubstring="+sub+"\nkeySet="+keySet()+"\naltSet="+altKeySet()+"\n";
}
assert(value!=null) : s+"\n"+keySet()+"\n"+altKeySet()+"\n";
return value;
}
public Scaffold getScaffold(SamLine sl){
return getScaffold(sl.rnameS());
}
public int getCoverage(Var v){
Scaffold scaf=getScaffold(v.scafnum);
return scaf.calcCoverage(v);
}
public long lengthSum() {
long sum=0;
for(Scaffold scaf : list){
sum+=scaf.length;
}
return sum;
}
public void clearCoverage() {
for(Scaffold scaf : list){scaf.clearCoverage();}
}
@Override
public String toString(){
StringBuilder sb=new StringBuilder();
for(Scaffold sc : list){sb.append(sc).append('\n');}
return sb.toString();
}
/*--------------------------------------------------------------*/
/*---------------- Fields ----------------*/
/*--------------------------------------------------------------*/
final ArrayList<Scaffold> list=new ArrayList<Scaffold>();
final HashMap<String, Scaffold> map=new HashMap<String, Scaffold>();
private final HashMap<String, Scaffold> alt=new HashMap<String, Scaffold>();
/*--------------------------------------------------------------*/
/*---------------- Static Fields ----------------*/
/*--------------------------------------------------------------*/
private static ScafMap defaultScafMap=null;
private static String defaultScafMapFile=null;
/**
*
*/
private static final long serialVersionUID = 1L;
public static boolean TRIM_WHITESPACE_ALSO=true;
}
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