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package var2;
import java.io.PrintStream;
import java.util.ArrayList;
import java.util.LinkedHashMap;
import java.util.Map.Entry;
import fileIO.ByteFile;
import fileIO.ByteFile1;
import fileIO.ByteFile2;
import fileIO.FileFormat;
import fileIO.ReadWrite;
import shared.Parse;
import shared.Parser;
import shared.PreParser;
import shared.Shared;
import shared.Timer;
import shared.Tools;
import stream.ConcurrentGenericReadInputStream;
import stream.FastaReadInputStream;
/**
* @author Brian Bushnell
* @date January 14, 2017
*
*/
public class VCFFile {
public static void main(String[] args){
{//Preparse block for help, config files, and outstream
PreParser pp=new PreParser(args, new Object() { }.getClass().getEnclosingClass(), false);
args=pp.args;
outstream=pp.outstream;
}
ReadWrite.USE_PIGZ=ReadWrite.USE_UNPIGZ=true;
ReadWrite.setZipThreads(Shared.threads());
VCFLine.AUTOCACHE=true;
Timer t=new Timer();
String in=null;
long maxLines=Long.MAX_VALUE;
Parser parser=new Parser();
for(int i=0; i<args.length; i++){
String arg=args[i];
String[] split=arg.split("=");
String a=split[0].toLowerCase();
String b=split.length>1 ? split[1] : null;
if(parser.parse(arg, a, b)){
//do nothing
}else if(a.equals("lines")){
maxLines=Long.parseLong(b);
if(maxLines<0){maxLines=Long.MAX_VALUE;}
}else if(a.equals("verbose")){
verbose=Parse.parseBoolean(b);
ByteFile1.verbose=verbose;
ByteFile2.verbose=verbose;
stream.FastaReadInputStream.verbose=verbose;
ConcurrentGenericReadInputStream.verbose=verbose;
stream.FastqReadInputStream.verbose=verbose;
ReadWrite.verbose=verbose;
}else{
outstream.println("Unknown parameter "+args[i]);
assert(false) : "Unknown parameter "+args[i];
// throw new RuntimeException("Unknown parameter "+args[i]);
}
}
{//Process parser fields
in=parser.in1;
}
assert(FastaReadInputStream.settingsOK());
if(in==null){throw new RuntimeException("Error - at least one input file is required.");}
if(!ByteFile.FORCE_MODE_BF2){
ByteFile.FORCE_MODE_BF2=false;
ByteFile.FORCE_MODE_BF1=true;
}
VCFFile vf=new VCFFile(in);
t.stop();
vf.printTime(t);
//Close the print stream if it was redirected
Shared.closeStream(outstream);
}
public VCFFile(String s){
in1=s;
ffin1=FileFormat.testInput(in1, FileFormat.TEXT, null, true, false);
load();
}
public VCFFile(FileFormat ff){
in1=ff.name();
ffin1=ff;
load();
}
void load(){
ByteFile bf=ByteFile.makeByteFile(ffin1);
byte[] line=bf.nextLine();
while(line!=null && (line.length==0 || line[0]=='#')){
if(line.length>0){
if(maxLines>0 && linesProcessed>=maxLines){break;}
linesProcessed++;
bytesProcessed+=line.length;
header.add(line);
if(Tools.startsWith(line, CHROM_POS)){
String[] split=new String(line).split("\t");
for(int i=9; i<split.length; i++){
sampleNames.add(split[i]);
}
}
}
line=bf.nextLine();
}
if(ScafMap.defaultScafMap()==null){ScafMap.setDefaultScafMap(toScafMap(null), in1);}
assert(ScafMap.defaultScafMap().size()>0) : ScafMap.defaultScafMap()+"\n"+headerToString();
while(line!=null){
if(line.length>0){
if(maxLines>0 && linesProcessed>=maxLines){break;}
linesProcessed++;
bytesProcessed+=line.length;
final boolean isHeader=(line[0]=='#');
if(isHeader){
header.add(line);
if(Tools.startsWith(line, CHROM_POS)){
String[] split=new String(line).split("\t");
for(int i=9; i<split.length; i++){
sampleNames.add(split[i]);
}
}
}else{
VCFLine vline=new VCFLine(line);
map.put(vline, vline);
}
}
line=bf.nextLine();
}
errorState|=bf.close();
}
// static ArrayList<byte[]> loadHeaderOnly(String fname){
// ByteFile bf=ByteFile.makeByteFile(fname, true);
// ArrayList<byte[]> header=new ArrayList<byte[]>();
// byte[] line=bf.nextLine();
// while(line!=null && (line.length==0 || line[0]=='#')){
// if(line.length>0){
// header.add(line);
// }
// line=bf.nextLine();
// }
// }
void printTime(Timer t){
outstream.println(Tools.timeLinesBytesProcessed(t, linesProcessed, bytesProcessed, 8));
outstream.println();
outstream.println("Header Lines: \t"+header.size());
outstream.println("Variant Lines: \t"+map.size());
}
public ArrayList<VCFLine> lines(boolean simplify){
ArrayList<VCFLine> lines=new ArrayList<VCFLine>(map.size());
for(Entry<VCFLine, VCFLine> e : map.entrySet()){
VCFLine line=e.getValue();
if(simplify && (line.isMulti() || line.isComplex())){
ArrayList<VCFLine> list=line.split(true, true, false);
lines.addAll(list);
}else{
lines.add(line);
}
}
return lines;
}
// public static ScafMap toScafMap(String vcf){
// assert(vcf!=null);
// if(vcf==null){return null;}
// if(sm==null){sm=new ScafMap();}
// for(byte[] line : header){
// if(Tools.startsWith(line, "##contig=<ID=")){
// sm.addFromVcf(line);
// }
// }
// return sm;
// }
public ScafMap toScafMap(ScafMap sm){
if(sm==null){sm=new ScafMap();}
for(byte[] line : header){
if(Tools.startsWith(line, "##contig=<ID=")){
sm.addFromVcf(line);
}
}
return sm;
}
public String headerToString(){
StringBuilder sb=new StringBuilder();
for(byte[] line : header){
for(byte b : line){
sb.append((char)b);
}
sb.append('\n');
}
return sb.toString();
}
/*--------------------------------------------------------------*/
public long linesProcessed() {
return linesProcessed;
}
public long bytesProcessed() {
return bytesProcessed;
}
/*--------------------------------------------------------------*/
private long linesProcessed=0;
private long bytesProcessed=0;
private long maxLines=Long.MAX_VALUE;
public ArrayList<byte[]> header=new ArrayList<byte[]>();
public ArrayList<String> sampleNames=new ArrayList<String>();
public LinkedHashMap<VCFLine, VCFLine> map=new LinkedHashMap<VCFLine, VCFLine>();
/*--------------------------------------------------------------*/
private String in1=null;
private final FileFormat ffin1;
/*--------------------------------------------------------------*/
public static final String CHROM_POS="#CHROM\tPOS\t";
private static PrintStream outstream=System.err;
public static boolean verbose=false;
public boolean errorState=false;
}
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