File: VarMap.java

package info (click to toggle)
bbmap 39.20%2Bdfsg-3
  • links: PTS, VCS
  • area: main
  • in suites: forky, sid
  • size: 26,024 kB
  • sloc: java: 312,743; sh: 18,099; python: 5,247; ansic: 2,074; perl: 96; makefile: 39; xml: 38
file content (716 lines) | stat: -rwxr-xr-x 22,885 bytes parent folder | download | duplicates (4)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
package var2;

import java.util.ArrayList;
import java.util.HashMap;
import java.util.Iterator;
import java.util.Map;
import java.util.Map.Entry;
import java.util.concurrent.ConcurrentHashMap;

import shared.Shared;
import shared.Tools;
import structures.ByteBuilder;

public class VarMap implements Iterable<Var> {
	
	/*--------------------------------------------------------------*/
	/*----------------        Construction          ----------------*/
	/*--------------------------------------------------------------*/
	
	VarMap(ScafMap scafMap_){
		this(scafMap_, -1, -1, -1, -1, -1);
	}

	@SuppressWarnings("unchecked")
	VarMap(ScafMap scafMap_, int ploidy_, double pairingRate_, double totalQualityAvg_,
			double mapqAvg_, double readLengthAvg_){
		scafMap=scafMap_;
		ploidy=ploidy_;
		properPairRate=pairingRate_;
		totalQualityAvg=totalQualityAvg_;
		totalMapqAvg=mapqAvg_;
		readLengthAvg=readLengthAvg_;
		maps=new ConcurrentHashMap[WAYS];
		for(int i=0; i<WAYS; i++){
			maps[i]=new ConcurrentHashMap<Var, Var>();
		}
	}
	
//	public static VarMap loadVars(String fname, ScafMap scafMap){
//		final ByteFile bf=ByteFile.makeByteFile(fname, true);
//		final VarMap varMap=new VarMap(scafMap);
//		final byte delimiter='\t';
//		int ploidy=-1;
//		double pairingRate=-1;
//		double mapqAvg=-1;
//		double totalQualityAvg=-1;
//		double readLengthAvg=-1;
//		byte[] line=bf.nextLine();
//		while(line!=null && line.length>0){
//			if(line[0]!='#'){
//				Var v=new Var(line, delimiter);
//				varMap.addUnsynchronized(v);
//			}else{
//				String[] split=new String(line).split("\t");
//				String a=split[0], b=(split.length>1 ? split[1] : null);
//				assert(split.length>1) : new String(line);
//				if(a.equalsIgnoreCase("#ploidy")){
//					ploidy=Integer.parseInt(b);
//				}else if(a.equalsIgnoreCase("#pairingRate")){
//					pairingRate=Double.parseDouble(b);
//				}else if(a.equalsIgnoreCase("#totalQualityAvg")){
//					totalQualityAvg=Double.parseDouble(b);
//				}else if(a.equalsIgnoreCase("#mapqAvg")){
//					mapqAvg=Double.parseDouble(b);
//				}else if(a.equalsIgnoreCase("#readLengthAvg")){
//					readLengthAvg=Double.parseDouble(b);
//				}
//			}
//			line=bf.nextLine();
//		}
//		bf.close();
//		varMap.ploidy=ploidy;
//		varMap.properPairRate=(double)pairingRate;
//		varMap.totalQualityAvg=(double)totalQualityAvg;
//		varMap.totalMapqAvg=(double)mapqAvg;
//		varMap.readLengthAvg=(double)readLengthAvg;
//		return varMap;
//	}
//	
//	//#CHROM POS    ID        REF  ALT     QUAL
//	public static VarMap loadVcf(String fname, ScafMap scafMap){
//		ByteFile bf=ByteFile.makeByteFile(fname, true);
//		VarMap varMap=new VarMap(scafMap);
//		byte[] line=bf.nextLine();
//		while(line!=null && line.length>0){
//			if(line[0]!='#'){
//				Var v;
//				try {
//					v = Var.fromVCF(line, scafMap);
//					varMap.addUnsynchronized(v);
//				} catch (Exception e) {
//					System.err.println("Unable to parse VCF line: '"+new String(line)+"'");
////					throw new RuntimeException(e);
//				}
//			}else{
//				String[] split=new String(line).split("=");
//				if(split.length==2){
//					String a=split[0], b=split[1];
//					if(a.equalsIgnoreCase("##ploidy")){
//						varMap.ploidy=Integer.parseInt(b);
//					}else if(a.equalsIgnoreCase("##properPairRate")){
//						varMap.properPairRate= Double.parseDouble(b);
//					}else if(a.equalsIgnoreCase("##totalQualityAvg")){
//						varMap.totalQualityAvg= Double.parseDouble(b);
//					}else if(a.equalsIgnoreCase("##mapqAvg")){
//						varMap.totalMapqAvg= Double.parseDouble(b);
//					}else if(a.equalsIgnoreCase("##readLengthAvg")){
//						varMap.readLengthAvg= Double.parseDouble(b);
//					}
//				}
//			}
//			line=bf.nextLine();
//		}
//		bf.close();
//		return varMap;
//	}
	
	/*--------------------------------------------------------------*/
	/*----------------           Methods            ----------------*/
	/*--------------------------------------------------------------*/
	
	public int countNearbyVars(VarFilter varFilter) {
		return countNearbyVars(varFilter, varFilter.maxNearbyCount, varFilter.nearbyDist, 
				varFilter.nearbyGap, varFilter.flagNearby);
	}
	
	public int countNearbyVars(VarFilter varFilter, final int maxCount0, final int maxDist, final int maxGap, final boolean flag) {
		final int maxCount=maxCount0<0 ? 19 : Tools.mid(maxCount0, 8, 19);
		final Var[] array=toArray(true);
		int failed=0;
		for(int vloc=0; vloc<array.length; vloc++){
			int x=countNearbyVars(varFilter, array, vloc, maxCount, maxDist, maxGap, flag);
			if(x>maxCount){failed++;}
		}
		return failed;
	}
	
	private boolean passesSolo(Var v, VarFilter varFilter){
		assert(varFilter!=null);
		if(varFilter==null){return true;}
		boolean pass=varFilter.passesFast(v);
		if(pass){
			v.calcCoverage(scafMap);
			pass=v.forced() || varFilter.passesFilter(v, properPairRate, totalQualityAvg,
					totalMapqAvg, readLengthAvg, ploidy, scafMap, false);
		}
		return pass;
	}
	
	public int countNearbyVars(VarFilter varFilter, final Var[] array, final int vloc0, final int maxCount, 
			final int maxDist, final int maxGap, final boolean flag) {
		final Var v0=array[vloc0];
		assert(v0.nearbyVarCount==-1) : "Nearby vars were already counted?";
		int nearby=0;
		
		{//Scan left
			Var prev=v0;
			for(int i=vloc0-1; i>=0 && nearby<=maxCount; i--){
				final Var v=array[i];
				//			v.stop==v.start means adjacent;
				if(prev.start-v.stop>maxGap || v0.start-v.stop>maxDist){break;}
				
				if(!v.forced() || passesSolo(v, varFilter)){
					nearby++;
					prev=v;
				}
			}
		}
		{//Scan right
			Var prev=v0;
			for(int i=vloc0+1; i<array.length && nearby<=maxCount; i++){
				final Var v=array[i];
				//			v.stop==v.start means adjacent;
				if(v.start-prev.stop>maxGap || v.start-v0.stop>maxDist){break;}
				
				if(!v.forced() || passesSolo(v, varFilter)){
					nearby++;
					prev=v;
				}
			}
		}
		v0.nearbyVarCount=nearby;
		if(flag && nearby>varFilter.maxNearbyCount){
			v0.setFlagged(true);
		}
		return nearby;
	}
	
	/*--------------------------------------------------------------*/
	/*----------------           Getters            ----------------*/
	/*--------------------------------------------------------------*/

	
	public boolean containsKey(Var v) {
		return get(v)!=null;
	}
	
	Var get(final Var v){
		final int way=v.start&MASK;
		return maps[way].get(v);
	}
	
	public long size(){
		long size=0;
		for(int i=0; i<maps.length; i++){size+=maps[i].size();}
		return size;
	}
	
	public long size2(){//123 Slow
		assert(false) : "Slow";
		int i=0;
		for(Var v : this){i++;}
		return i;
	}
	
	/*--------------------------------------------------------------*/
	/*----------------            Adders            ----------------*/
	/*--------------------------------------------------------------*/
	
	private int add(final Var v){
//		assert(size()==size2());//123;
//		assert(mappedToSelf(false));//123
		final ConcurrentHashMap<Var, Var> map=maps[v.start&MASK];
		synchronized(map){
			Var old=map.get(v);
			if(old==null){
				map.put(v, v);
//				assert(mappedToSelf(false));//123
				return 1;
			}
			else{
				synchronized(old){
					old.add(v);
//					assert(mappedToSelf(false));//123
				}
			}
		}
//		assert(size()==size2());//123;
//		assert(mappedToSelf(false));//123
		return 0;
	}
	
	int addUnsynchronized(final Var v){
//		assert(mappedToSelf(false));//123
		final ConcurrentHashMap<Var, Var> map=maps[v.start&MASK];
		Var old=map.get(v);
		if(old==null){
			map.put(v, v);
//			assert(mappedToSelf(false));//123
			return 1;
		}
		old.add(v);
//		assert(mappedToSelf(false));//123
		return 0;
	}
	
	int removeUnsynchronized(Var v){
		final ConcurrentHashMap<Var, Var> map=maps[v.start&MASK];
		return map.remove(v)==null ? 0 : 1;
	}
	
	int dumpVars(HashMap<Var, Var> mapT){
		int added=0;
		@SuppressWarnings("unchecked")
		ArrayList<Var>[] absent=new ArrayList[WAYS];
		for(int i=0; i<WAYS; i++){
			absent[i]=new ArrayList<Var>();
		}
		for(Entry<Var, Var> e : mapT.entrySet()){
			Var v=e.getValue();
			final int way=v.start&MASK;
			ConcurrentHashMap<Var, Var> map=maps[way];
			Var old=map.get(v);
			if(old==null){absent[way].add(v);}
			else{
				synchronized(old){
					old.add(v);
				}
			}
		}
		
		mapT.clear();
		for(int way=0; way<WAYS; way++){
			ConcurrentHashMap<Var, Var> map=maps[way];
			ArrayList<Var> list=absent[way];
			synchronized(map){
				for(Var v : list){
					Var old=get(v);
					if(old==null){
						map.put(v, v);
						added++;
					}
					else{
						synchronized(old){
							old.add(v);
						}
					}
				}
			}
		}
		return added;
	}
	
	/*--------------------------------------------------------------*/
	/*----------------            Other             ----------------*/
	/*--------------------------------------------------------------*/

	public long[] processVariantsST(VarFilter filter, long[][] scoreArray, long[] ploidyArray, long[][] avgQualityArray,
			long[] maxQualityArray, long[][] ADArray, double[] AFArray) {
		assert(properPairRate>=0);
		assert(ploidy>0);
		assert(totalQualityAvg>=0);
		
		long[] types=new long[Var.VAR_TYPES];
		for(ConcurrentHashMap<Var, Var> map : maps){
			long[] types2=processVariants(map, filter, null, null, null, null, null, null, false, false);
			types2=processVariants(map, filter, null, null, null, null, null, null, true, false);
			types2=processVariants(map, filter, scoreArray, ploidyArray, avgQualityArray, maxQualityArray, ADArray, AFArray, false, false);
			Tools.add(types, types2);
		}
		return types;
	}
	
//	public long[] addSharedVariantsST(VarFilter filter, VarMap sharedVarMap) {
//		assert(properPairRate>=0);
//		assert(ploidy>0);
//		assert(totalQualityAvg>=0);
//		
//		long[] types=new long[Var.VAR_TYPES];
//		for(int i=0; i<maps.length; i++){
//			long[] types2=addSharedVariants(maps[i], sharedVarMap.maps[i]);
//			Tools.add(types, types2);
//		}
//		return types;
//	}
	
	public long[] processVariantsMT(VarFilter filter, long[][] scoreArray, long[] ploidyArray, 
			long[][] avgQualityArray, long[] maxQualityArray, long[][] ADArray, double[] AFArray) {
		processVariantsMT_inner(filter, null, null, null, null, null, null, false);
		processVariantsMT_inner(filter, null, null, null, null, null, null, true);
		return processVariantsMT_inner(filter, scoreArray, ploidyArray, avgQualityArray, maxQualityArray, ADArray, AFArray, false);
	}
	
	private long[] processVariantsMT_inner(VarFilter filter, long[][] scoreArray, long[] ploidyArray, 
			long[][] avgQualityArray, long[] maxQualityArray, long[][] ADArray, double[] AFArray, boolean processInsertions) {
		assert(properPairRate>=0);
		assert(ploidy>0);
		assert(totalQualityAvg>=0);
		
		ArrayList<ProcessThread> alpt=new ArrayList<ProcessThread>(WAYS);
		for(int i=0; i<WAYS; i++){
			ProcessThread pt=new ProcessThread(maps[i], filter, scoreArray!=null, ploidyArray!=null, avgQualityArray!=null, ADArray!=null, processInsertions);
			alpt.add(pt);
			pt.start();
		}
		
		long[] types=new long[Var.VAR_TYPES];
		boolean success=true;
		for(ProcessThread pt : alpt){
			//Wait until this thread has terminated
			while(pt.getState()!=Thread.State.TERMINATED){
				try {
					//Attempt a join operation
					pt.join();
				} catch (InterruptedException e) {
					//Potentially handle this, if it is expected to occur
					e.printStackTrace();
				}
			}
			
			//Accumulate per-thread statistics
			if(pt.types!=null){
				Tools.add(types, pt.types);
			}
			if(scoreArray!=null){Tools.add(scoreArray, pt.scoreArray);}
			if(ploidyArray!=null){Tools.add(ploidyArray, pt.ploidyArray);}
			if(avgQualityArray!=null){Tools.add(avgQualityArray, pt.avgQualityArray);}
			if(maxQualityArray!=null){Tools.add(maxQualityArray, pt.maxQualityArray);}
			if(ADArray!=null){Tools.add(ADArray, pt.ADArray);}
			if(ADArray!=null){Tools.add(AFArray, pt.AFArray);}//Note this is triggered on ADArray
			success&=pt.success;
		}
		
		//Track whether any threads failed
//		if(!success){errorState=true;}
		
		return types;
	}
	
	private class ProcessThread extends Thread {
		
		ProcessThread(Map<Var, Var> map_, VarFilter filter_, boolean trackScores, boolean trackPloidy, 
				boolean trackQuality, boolean trackAD, boolean processInsertions_){
			map=map_;
			filter=filter_;
			scoreArray=(trackScores ? new long[8][200] : null);
			ploidyArray=(trackPloidy ? new long[ploidy+1] : null);
			avgQualityArray=(trackQuality ? new long[8][100] : null);
			maxQualityArray=(trackQuality ? new long[100] : null);
			ADArray=(trackAD ? new long[2][7] : null);
			AFArray=(trackAD ? new double[7] : null);
			processInsertions=processInsertions_;
		}
		
		@Override
		public void run(){
			types=processVariants(map, filter, scoreArray, ploidyArray, avgQualityArray, maxQualityArray, ADArray, AFArray, processInsertions, false);
			success=true;
		}
		
		final VarFilter filter;
		final Map<Var, Var> map;
		long[] types;
		final long[][] scoreArray;
		final long[] ploidyArray;
		final long[][] avgQualityArray;
		final long[] maxQualityArray;
		final long[][] ADArray;
		final double[] AFArray;
		boolean processInsertions;
		boolean success=false;
	}

	private long[] processVariants(Map<Var, Var> map, VarFilter filter, long[][] scoreArray, long[] ploidyArray, 
			long[][] avgQualityArray, long[] maxQualityArray, long[][] ADArray, double[] AFArray, boolean processInsertions, boolean considerNearby) {
		assert(properPairRate>=0);
		assert(ploidy>0);
		assert(totalQualityAvg>=0);
		Iterator<Entry<Var, Var>> iterator=map.entrySet().iterator();
		long[] types=new long[Var.VAR_TYPES];
		while(iterator.hasNext()){
			Entry<Var, Var> entry=iterator.next();
			final Var v=entry.getValue();
			
			if(processInsertions){
				assert(readLengthAvg>0);
				if(v.type()==Var.INS){
					synchronized(v){
						v.reviseAlleleFraction(readLengthAvg, scafMap.getScaffold(v.scafnum), this);
					}
				}
			}else{
				boolean pass=filter.passesFast(v);
				if(pass){
					v.calcCoverage(scafMap);
					pass=v.forced() || filter.passesFilter(v, properPairRate, totalQualityAvg, totalMapqAvg, readLengthAvg, ploidy, scafMap, considerNearby);
				}
				if(pass){
					types[v.type()]++;
					if(scoreArray!=null){
						int score=(int)v.phredScore(properPairRate, totalQualityAvg, totalMapqAvg, readLengthAvg, filter.rarity, ploidy, scafMap);
						scoreArray[0][score]++;
						scoreArray[v.type()+1][score]++;
					}
					if(ploidyArray!=null){ploidyArray[v.calcCopies(ploidy)]++;}
					if(avgQualityArray!=null){
						int q=(int)v.baseQAvg();
						avgQualityArray[0][q]++;
						avgQualityArray[v.type()+1][q]++;
					}
					if(maxQualityArray!=null){maxQualityArray[(int)v.baseQMax]++;}
					if(ADArray!=null){
						ADArray[0][v.type()]+=v.alleleCount();
						ADArray[1][v.type()]+=v.coverage();
					}
					if(AFArray!=null){AFArray[v.type()]+=v.alleleFraction();}
				}else{
					iterator.remove();
				}
			}
		}
		return types;
	}

	private long[] addSharedVariants(Map<Var, Var> map, Map<Var, Var> sharedMap) {
		assert(properPairRate>=0);
		assert(ploidy>0);
		assert(totalQualityAvg>=0);
		
		for(Var v : sharedMap.keySet()){
			if(!map.containsKey(v)){
				Var v2=new Var(v);
				map.put(v2, v2);
			}
		}
		
		long[] types=new long[Var.VAR_TYPES];
		for(Var v : sharedMap.keySet()){
			v.calcCoverage(scafMap);
			types[v.type()]++;
		}
		return types;
	}
	
	public Var[] toArray(boolean sort) {
		Var[] array=new Var[(int)size()];
		int i=0;
		
//		assert(mappedToSelf(true));//123
		
		for(Var v : this){
//			System.err.println(i+"\t"+v.start+"\t"+v.stop+"\t"+v.toKey()+"\t"+new String(v.allele)+"\t"+((Object)v).hashCode());//123
			assert(i<array.length);
			array[i]=v;
			i++;
		}
		if(sort){Shared.sort(array);}
		return array;
	}
	
	private boolean mappedToSelf(boolean quiet){//123 slow
		assert(false) : "Slow";
		for(ConcurrentHashMap<Var, Var> map : maps){
			for(Var key : map.keySet()){
				Var value=map.get(key);
				assert(value!=null);
				assert(value.equals(key));
				assert(value==key);
				assert(map.get(value).equals(key));
			}
			for(Entry<Var, Var> e : map.entrySet()){
				Var key=e.getKey();
				Var value=e.getValue();
				assert(value!=null);
				assert(value.equals(key));
				assert(value==key);
			}
			for(ConcurrentHashMap<Var, Var> map2 : maps){
				if(map2!=map){
					for(Var key : map.keySet()){
						assert(!map2.containsKey(key));
					}
				}
			}
		}
		int i=0;
		for(Var v : this){
			if(!quiet){System.err.println(i+"\t"+v.start+"\t"+v.stop+"\t"+v.toKey()+"\t"+v.hashcode+"\t"+v.hashCode()+"\t"+new String(v.allele)+"\t"+((Object)v).hashCode());}
			Var v2=get(v);
			assert(v==v2);
			assert(get(v2)==v);
			assert(get(v)==v) : "\n"+i+"\t"+v2.start+"\t"+v2.stop+"\t"+v2.toKey()+"\t"+v2.hashcode+"\t"+v2.hashCode()+"\t"+new String(v2.allele)+"\t"+((Object)v2).hashCode();
			i++;
		}
		assert(i==size()) : i+", "+size()+", "+size2();
//		assert(false) : i+", "+size();
		return true;
	}
	
	public long[] calcCoverage(ScafMap scafMap) {
		long[] types=new long[Var.VAR_TYPES];
		for(Var v : this){
			v.calcCoverage(scafMap);
			types[v.type()]++;
		}
		return types;
	}
	
	public long[] countTypes() {
		long[] types=new long[Var.VAR_TYPES];
		for(Var v : this){
			types[v.type()]++;
		}
		return types;
	}
	
//	public void writeVarFile_(FileFormat ff, VarFilter filter, long reads, long pairs, long properPairs, long bases, String ref){
//		Var[] array=toArray(true);
//		ByteStreamWriter bsw=new ByteStreamWriter(ff);
//		bsw.start();
//		ByteBuilder bb=new ByteBuilder(33000);
//		bb.append(Var.toVarHeader(properPairRate, totalQualityAvg, totalMapqAvg, filter.rarity, filter.minAlleleFraction,
//				ploidy, reads, pairs, properPairs, bases, ref)).append('\n');
//		for(Var v : array){
//			v.toText(bb, properPairRate, totalQualityAvg, totalMapqAvg, readLengthAvg, filter.rarity, ploidy, scafMap);//TODO: Track depth
//			bb.nl();
//			if(bb.length()>16384){
//				bsw.print(bb);
//				bb.clear();
//			}
//		}
//		if(bb.length()>0){
//			bsw.print(bb);
//			bb.clear();
//		}
//		bsw.poisonAndWait();
//	}
//	
//	public void writeVcfFile_(String fname, VarFilter filter, long reads, long pairs, long properPairs, long bases, String ref, String sampleName, boolean trimWhitespace){
//		FileFormat ff=FileFormat.testOutput(fname, FileFormat.TEXT, null, true, true, false, false);
//		writeVcfFile(ff, filter, reads, pairs, properPairs, bases, ref, sampleName, trimWhitespace);
//	}
//	
//	public void writeVcfFile_(FileFormat ff, VarFilter filter, long reads, long pairs, long properPairs, long bases, String ref, String sampleName, boolean trimWhitespace){
//		Var[] array=toArray(true);
//		ByteStreamWriter bsw=new ByteStreamWriter(ff);
//		bsw.start();
//		ByteBuilder bb=new ByteBuilder(33000);
//		bb.append(Var.toVcfHeader(properPairRate, totalQualityAvg, totalMapqAvg, filter.rarity, filter.minAlleleFraction,
//				ploidy, reads, pairs, properPairs, bases, ref, scafMap, sampleName, trimWhitespace)).append('\n');
//		for(Var v : array){
//			v.toVCF(bb, properPairRate, totalQualityAvg, totalMapqAvg, readLengthAvg, ploidy, scafMap, filter, trimWhitespace);
//			bb.nl();
//			if(bb.length()>16384){
//				bsw.print(bb);
//				bb.clear();
//			}
//		}
//		if(bb.length()>0){
//			bsw.print(bb);
//			bb.clear();
//		}
//		bsw.poisonAndWait();
//	}
	
	
	public void clear() {
//		assert(mappedToSelf(false));//123
		properPairRate=-1;
		pairedInSequencingRate=-1;
		totalQualityAvg=-1;
		totalMapqAvg=-1;
		readLengthAvg=-1;
		for(int i=0; i<maps.length; i++){
			maps[i]=new ConcurrentHashMap<Var, Var>();
		}
//		assert(mappedToSelf(false));//123
	}
	
	@Override
	public String toString(){
		ByteBuilder sb=new ByteBuilder();
		for(ConcurrentHashMap<Var, Var> map : maps){
			for(Var v : map.keySet()){
				v.toTextQuick(sb);
				sb.nl();
			}
		}
		return sb.toString();
	}
	
	/*--------------------------------------------------------------*/
	/*----------------          Iteration           ----------------*/
	/*--------------------------------------------------------------*/
	
	@Override
	public VarMapIterator iterator(){
//		if(maps.length==1){return (maps[1].entrySet().iterator();}
		return new VarMapIterator();
	}
	
	private class VarMapIterator implements Iterator<Var> {

		VarMapIterator(){
//			System.err.println("\nInit: ("+this.hashCode()+")");//123
			makeReady();
		}
		
		@Override
		public boolean hasNext() {
			return iter.hasNext();
		}

		@Override
		public Var next() {
//			System.err.println("\nNext: ("+this.hashCode()+")");//123
			Entry<Var, Var> e=iter.next();
			if(!iter.hasNext()){makeReady();}
			Var v=e==null ? null : e.getValue();
//			System.err.println("Var "+v.hashCode());//123
			return v;
		}
		
		private void makeReady(){
//			System.err.println("\nmakeReady ("+this.hashCode()+")");//123
//			System.err.println("iter="+iter+", nextMap="+nextMap);//123
			while((iter==null || !iter.hasNext()) && nextMap<maps.length){
				iter=maps[nextMap].entrySet().iterator();
				nextMap++;
//				System.err.println("iter="+iter+", nextMap="+nextMap+" (loop)");//123
			}
//			System.err.println("break");//123
		}
		
		private int nextMap=0;
		private Iterator<Entry<Var, Var>> iter=null;
		
	}
	
	/*--------------------------------------------------------------*/
	/*----------------           Fields             ----------------*/
	/*--------------------------------------------------------------*/
	
	
	public int ploidy=-1;
	public double properPairRate=-1;
	public double pairedInSequencingRate=-1;
	public double totalQualityAvg=-1;
	public double totalMapqAvg=-1;
	public double readLengthAvg=-1;
	public final ScafMap scafMap;
	final ConcurrentHashMap<Var, Var>[] maps; //ConcurrentHashMap appears to be faster than HashMap here, if there are lots of threads.
	
	/*--------------------------------------------------------------*/
	/*----------------        Static fields         ----------------*/
	/*--------------------------------------------------------------*/

	/**
	 * 
	 */
	private static final long serialVersionUID = 1L;
	/** Must be a power of 2.  Max Vars stored is ways times 2 billion  */
	private static final int WAYS=8;
	public static final int MASK=WAYS-1;
	
}