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/*
* Copyright (C) 2014-2021 Brian L. Browning
*
* This file is part of Beagle
*
* Beagle is free software: you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* Beagle is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with this program. If not, see <http://www.gnu.org/licenses/>.
*/
package bref;
import ints.IntArray;
import ints.IntList;
import java.util.ArrayList;
import java.util.Arrays;
import java.util.Collections;
import java.util.List;
import vcf.Marker;
import vcf.RefGTRec;
import vcf.Samples;
import vcf.SeqCodedRefGTRec;
/**
* <p>Class {@code SeqCoder3} compresses a sequence of allele-coded
* {@code RefGTRec} objects. The class is designed for use with bref v3 format.
* Compression is performed by storing the list of distinct allele sequences
* and the allele sequence carried by each haplotype.
* </p>
* <p>Class {@code SeqCoder3} is not thread-safe.
* </p>
*
* @author Brian L. Browning {@code <browning@uw.edu>}
*/
public class SeqCoder3 {
/**
* The maximum number of alleles are that permitted in order
* for the {@code add()} method to return {@code true}
*/
public static final int MAX_NALLELES = 255;
/**
* The major allele frequency threshold for allele coding.
* Sequence coding should only be applied if the major allele frequency
* less than or equal to this threshold.
*/
public static final float COMPRESS_FREQ_THRESHOLD = 0.995f;
private final Samples samples;
private final int maxNSeq;
private final List<RefGTRec> recs;
private final int[] hap2Seq;
private final IntList seq2Cnt; // for processiing allele-coded markers
private final List<IntList> seq2AlleleMap;
/**
* Constructs a new {@code SeqCoder3} for the specified samples.
* @param samples the list of samples whose data will be compressed
* @throws NullPointerException if {@code samples == null}
*/
public SeqCoder3(Samples samples) {
this(samples, defaultMaxNSeq(samples.size()));
}
/**
* Constructs a new {@code SeqCoder3} for the specified samples.
* @param samples the list of samples whose data will be compressed
* @param maxNSeq the maximum number of distinct allele sequences
* permitted if the {@code add()} method returns {@code true}
* @throws NullPointerException if {@code samples == null}
* @throws IllegalArgumentException
* {@code maxNSeq < 0 || maxNSeq >= Chracter.MAX_VALUE}
*/
public SeqCoder3(Samples samples, int maxNSeq) {
if (maxNSeq < 0 || maxNSeq >= Character.MAX_VALUE) {
throw new IllegalArgumentException(String.valueOf(maxNSeq));
}
this.samples = samples;
this.maxNSeq = maxNSeq;
this.recs = new ArrayList<>(100);
this.hap2Seq = new int[2*samples.size()];
this.seq2Cnt = new IntList(3*maxNSeq/2 + 1);
this.seq2AlleleMap = new ArrayList<>(maxNSeq + 1);
initialize();
}
/**
* Returns the default maximum number of sequences for the specified
* number of samples. The default value is equal to
* {@code (int) Math.min((long) Math.pow(2, 2*Math.log10(size) + 1),
Character.MAX_VALUE)}
* @param nSamples the number of samples
* @return the default maximum number of sequences for the specified
* number of samples
* @throws IllegalArgumentException if {@code size < 1}
*/
public static int defaultMaxNSeq(int nSamples) {
if (nSamples < 1) {
throw new IllegalArgumentException(String.valueOf(nSamples));
}
if (nSamples==1) {
return 3;
}
else {
double exponent = 2*Math.log10(nSamples) + 1;
long maxNSeq = (long) Math.floor(Math.pow(2.0, exponent));
if (maxNSeq > Character.MAX_VALUE) {
return Character.MAX_VALUE;
}
else {
return (int) maxNSeq;
}
}
}
/**
* Returns the list of samples whose phased genotype data will be compressed.
* @return the list of samples whose phased genotype data will be compressed
*/
public Samples samples() {
return samples;
}
/**
* Returns the number of compressed {@code RefGTRec} objects.
* @return the number of compressed {@code RefGTRec} objects
*/
public int nRecs() {
return recs.size();
}
/**
* Returns the maximum number of distinct allele sequences.
* @return the maximum number of distinct allele sequences
*/
public int maxNSeq() {
return maxNSeq;
}
/**
* Attempts to add the specified {@code RefGTRec} object to the list of
* compressed {@code RefGTRec} objects, and returns {@code true}
* if the {@code RefGTRec} object was added.
*
* @param rec reference genotypes for a marker
* @return {@code true} if the specified {@code RefGTRec} object was
* added to the list of compressed markers
*
* @throws IllegalArgumentException if
* {@code em.samples().equals(this.samples()) == false}
* @throws IllegalArgumentException if
* {@code rec.isAlleleCoded() == false}
* @throws NullPointerException if {@code rec == null}
*/
public boolean add(RefGTRec rec) {
if (rec.samples().equals(samples)==false) {
throw new IllegalArgumentException("inconsistent samples");
}
if (rec.isAlleleCoded()==false) {
throw new IllegalArgumentException(rec.getClass().toString());
}
boolean success = setAlleleMap(rec);
if (success) {
recs.add(rec);
int majorAllele = rec.majorAllele();
for (int a=0, n=rec.marker().nAlleles(); a<n; ++a) {
if (a!=majorAllele) {
int nCopies = rec.alleleCount(a);
for (int c=0; c<nCopies; ++c) {
int h = rec.hapIndex(a, c);
int oldSeq = hap2Seq[h];
IntList list = seq2AlleleMap.get(oldSeq);
int index=0;
while (index<list.size() && list.get(index)!=a) {
index+=2;
}
int newSeq = list.get(index+1);
if (newSeq != oldSeq) {
while (newSeq >= seq2Cnt.size()) {
seq2Cnt.add(0);
}
hap2Seq[h] = newSeq;
seq2Cnt.decrementAndGet(oldSeq);
seq2Cnt.incrementAndGet(newSeq);
}
}
}
}
}
assert seq2Cnt.size()==seq2AlleleMap.size();
return success;
}
private void clearAlleleMap() {
for (int j=0, n=seq2AlleleMap.size(); j<n; ++j) {
seq2AlleleMap.get(j).clear();
}
}
private boolean setAlleleMap(RefGTRec rec) {
assert seq2Cnt.size()==seq2AlleleMap.size();
int nStartSeq = seq2Cnt.size();
int[] seq2NonMajorCnt = new int[nStartSeq];
clearAlleleMap();
int nAlleles = rec.marker().nAlleles();
int majorAllele = rec.majorAllele();
for (int a=0; a<nAlleles; ++a) {
if (a!=majorAllele) {
int nCopies = rec.alleleCount(a);
for (int c=0; c<nCopies; ++c) {
int h = rec.hapIndex(a, c);
int seq = hap2Seq[h];
++seq2NonMajorCnt[seq];
IntList list = seq2AlleleMap.get(seq);
if (list.isEmpty()) {
list.add(a);
list.add(seq);
}
else {
int index=0;
while (index<list.size() && list.get(index)!=a) {
index+=2;
}
if (index==list.size()) {
list.add(a);
list.add(seq2AlleleMap.size());
seq2AlleleMap.add(new IntList(4));
}
}
}
}
}
addMajorAllele(seq2NonMajorCnt, majorAllele);
if (seq2AlleleMap.size() >= maxNSeq) {
seq2AlleleMap.subList(nStartSeq, seq2AlleleMap.size()).clear();
return false;
}
else {
return true;
}
}
private void addMajorAllele(int[] seq2NonMajorCnt, int majorAllele) {
for (int s=0; s<seq2NonMajorCnt.length; ++s) {
if (seq2NonMajorCnt[s] < seq2Cnt.get(s)) {
IntList list = seq2AlleleMap.get(s);
if (list.isEmpty()) {
list.add(majorAllele);
list.add(s);
}
else {
// assign major allele the existing sequence index
list.add(list.get(0));
assert list.get(1)==s;
list.add(seq2AlleleMap.size());
list.set(0, majorAllele);
seq2AlleleMap.add(new IntList(4));
}
}
}
}
/**
* Returns and clears the stored list of compressed {@code RefGTRec}
* objects.
*
* @return the list of compressed {@code RefGTRec} objects
*/
public List<RefGTRec> getCompressedList() {
if (recs.isEmpty()) {
return Collections.emptyList();
}
List<RefGTRec> list = new ArrayList<>(recs.size());
int[] seq2Hap = seq2Hap(); // can this be created when adding records?
IntArray hap2seq = IntArray.packedCreate(hap2Seq, seq2Hap.length);
for (int j=0, n=recs.size(); j<n; ++j) {
RefGTRec rec = recs.get(j);
Marker m = rec.marker();
IntArray seq2allele = seq2Allele(rec, seq2Hap);
list.add(new SeqCodedRefGTRec(m, samples, hap2seq, seq2allele));
}
initialize();
return list;
}
private int[] seq2Hap() {
int[] seqToHap = new int[seq2AlleleMap.size()];
Arrays.fill(seqToHap, -1);
for (int h=0; h<hap2Seq.length; ++h) {
int seq = hap2Seq[h];
if (seqToHap[seq] == -1) {
seqToHap[seq] = h;
}
}
return seqToHap;
}
private IntArray seq2Allele(RefGTRec rec, int[] seq2Hap) {
int[] seq2Allele = new int[seq2Hap.length];
for (int j=0; j<seq2Allele.length; ++j) {
seq2Allele[j] = rec.get(seq2Hap[j]);
}
return IntArray.packedCreate(seq2Allele, rec.marker().nAlleles());
}
/**
* Clears the list of compressed {@code RefGTRec} objects.
*/
private void initialize() {
recs.clear();
seq2Cnt.clear();
seq2AlleleMap.clear();
// initialize with empty sequence (seq index is 0)
Arrays.fill(hap2Seq, 0);
seq2Cnt.add(hap2Seq.length);
seq2AlleleMap.add(new IntList(4));
}
}
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