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/*
* Copyright (C) 2014-2021 Brian L. Browning
*
* This file is part of Beagle
*
* Beagle is free software: you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* Beagle is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with this program. If not, see <http://www.gnu.org/licenses/>.
*/
package vcf;
import blbutil.Const;
import java.util.stream.IntStream;
/**
* <p>Class {@code BasicGT} represents genotypes for a list of markers and
* samples.</p>
*
* <p>Instances of class {@code BasicGT} are immutable</p>
*
* @author Brian L. Browning {@code <browning@uw.edu>}
*/
public final class BasicGT implements GT {
private final Samples samples;
private final Markers markers;
private final GTRec[] recs;
private final boolean isRefData;
/**
* Returns the genotype index corresponding to the specified unordered
* alleles.
* @param a1 the first allele index of an unordered genotype
* @param a2 the second allele index of an unordered genotype
* @return the genotype index corresponding to the specified unordered
* alleles
* @throws IllegalArgumentException if {@code a1 < 0 || a2 < 0}
*/
public static int genotype(int a1, int a2) {
if (a1<=a2) {
if (a1 < 0) {
String s = "allele < 0: " + a1 + " " + a2;
throw new IllegalArgumentException(s);
}
return (a2*(a2+1))/2 + a1;
}
else {
if (a2<0) {
String s = "allele < 0: " + a1 + " " + a2;
throw new IllegalArgumentException(s);
}
return (a1*(a1+1))/2 + a2;
}
}
/**
* Constructs a {@code BasicGT} instance from the specified data
* @param recs genotype records for a list of markers
* @throws IllegalArgumentException
* if elements of {@code recs} corresponding to the same chromosome
* are not contiguous and sorted in chromosome position order
* @throws IllegalArgumentException if {@code recs.length == 0}
* @throws IllegalArgumentException if any two elements of
* {@code recs} correspond to the same genetic marker
* @throws IllegalArgumentException if
* {@code (recs[j].samples().equals(recs[k].samples()) == false)} for any
* {@code j, k} satisfying {@code (0 <= j && j < k && j < recs.length)}
* @throws NullPointerException if {@code recs == null}
* @throws NullPointerException if {@code (recs[j] == null)} any {@code j}
* satisfying {@code (0 <= j && j < recs.length)}
*/
public BasicGT(GTRec[] recs) {
this(recs[0].samples(), recs);
}
/**
* Constructs a {@code BasicGT} instance from the specified data
* @param samples the list of samples with genotype data
* @param recs genotype records for a list of markers
* @throws IllegalArgumentException
* if elements of {@code recs} corresponding to the same chromosome
* are not contiguous and sorted in chromosome position order
* @throws IllegalArgumentException if any two elements of
* {@code recs} correspond to the same genetic marker
* @throws IllegalArgumentException if
* {@code (recs[j].samples().equals(samples) == false)} for any {@code j}
* satisfying {@code (0 <= j && j < recs.length)}
* @throws NullPointerException if {@code samples == null || recs == null}
* @throws NullPointerException if {@code (recs[j] == null)} any {@code j}
* satisfying {@code (0 <= j && j < recs.length)}
*/
public BasicGT(Samples samples, GTRec[] recs) {
checkSamples(samples, recs);
this.markers = markers(recs);
this.samples = samples;
this.recs = recs.clone();
this.isRefData = isRefData(recs);
}
/**
* Constructs a {@code BasicGT} instance from the specified data.
* @param markers the list of markers with genotype data
* @param samples the list of samples with genotype data
* @param recs the genotype data for each marker
* @throws IllegalArgumentException if
* {@code (recs[j].marker().equals(markers.marker(j)) == false)} for any
* {@code j} satisfying {@code (0 <= j && j < recs.length)}
* @throws IllegalArgumentException if
* {@code (recs[j].samples().equals(samples) == false)} for any {@code j}
* satisfying {@code (0 <= j && j < recs.length)}
* @throws NullPointerException if
* {@code (markers == null || samples == null || recs == null)}
* @throws NullPointerException if {@code (recs[j] == null)} any {@code j}
* satisfying {@code (0 <= j && j < recs.length)}
*/
public BasicGT(Markers markers, Samples samples, GTRec[] recs) {
checkMarkersAndSamples(markers, samples, recs);
this.markers = markers;
this.samples = samples;
this.recs = recs.clone();
this.isRefData = isRefData(recs);
}
private static void checkSamples(Samples samples, GTRec[] recs) {
for (int j=0; j<recs.length; ++j) {
if (recs[j].samples().equals(samples)==false) {
throw new IllegalArgumentException("inconsistent samples");
}
}
}
private static void checkMarkersAndSamples(Markers markers, Samples samples,
GTRec[] recs) {
for (int j=0; j<recs.length; ++j) {
if (recs[j].marker().equals(markers.marker(j))==false) {
throw new IllegalArgumentException("inconsistent markers");
}
if (recs[j].samples().equals(samples)==false) {
throw new IllegalArgumentException("inconsistent samples");
}
}
}
private static Markers markers(GTRec[] recs) {
Marker[] markers = new Marker[recs.length];
for (int j=0; j<markers.length; ++j) {
markers[j] = recs[j].marker();
}
return Markers.create(markers);
}
private static boolean isRefData(GTRec[] recs) {
boolean isRefData = true;
for (int j=0; j<recs.length && isRefData==true; ++j) {
if (recs[j].isPhased()==false) {
isRefData = false;
}
}
return isRefData;
}
@Override
public boolean isReversed() {
return false;
}
@Override
public int nMarkers() {
return recs.length;
}
@Override
public Marker marker(int markerIndex) {
return markers.marker(markerIndex);
}
@Override
public Markers markers() {
return markers;
}
@Override
public int nHaps() {
return 2*samples.size();
}
@Override
public int nSamples() {
return samples.size();
}
@Override
public Samples samples() {
return samples;
}
@Override
public boolean isPhased() {
return isRefData;
}
@Override
public int allele1(int marker, int sample) {
return recs[marker].allele1(sample);
}
@Override
public int allele2(int marker, int sample) {
return recs[marker].allele2(sample);
}
@Override
public int allele(int marker, int hap) {
return recs[marker].get(hap);
}
/**
* Returns a {@code BasicGT} instance restricted to genotype data for
* the specified markers.
* @param gt the {@code BasicGT} instance to be restricted
* @param indices a list of distinct marker indices (from
* {@code this.markers())} in increasing order
* @return a {@code GT} instance restricted to genotype data for
* the specified markers
*
* @throws IndexOutOfBoundsException if there exists {@code j} such that
* {@code (0 <= j && j < indices.length)} such that
* {@code (indices[j] < 0 || indices[j] >= gt.nMarkers())}
* @throws IllegalArgumentException if there exists {@code j} such that
* {@code (1 <= j && j < indices.length)} such that
* {@code (indices[j] <= indice[j - 1])}
* @throws NullPointerException if {@code gt == null || indices == null}
*/
public static BasicGT restrict(BasicGT gt, int[] indices) {
Markers restrictMarkers = gt.markers.restrict(indices);
GTRec[] restrictedRecs = IntStream.range(0, indices.length)
.mapToObj(j -> gt.recs[indices[j]])
.toArray(GTRec[]::new);
return new BasicGT(restrictMarkers, gt.samples, restrictedRecs);
}
@Override
public BasicGT restrict(Markers restrictedMarkers, int[] indices) {
GTRec[] restrictedRecs = IntStream.range(0, indices.length)
.mapToObj(j -> recs[indices[j]])
.toArray(GTRec[]::new);
return new BasicGT(restrictedMarkers, samples, restrictedRecs);
}
@Override
public BasicGT restrict(int start, int end) {
Markers restrictMarkers = markers.restrict(start, end);
GTRec[] restrictRecs = IntStream.range(start, end)
.mapToObj(j -> recs[j])
.toArray(GTRec[]::new);
return new BasicGT(restrictMarkers, samples, restrictRecs);
}
/**
* Returns a string representation of {@code this}. The exact details
* of the representation are unspecified and subject to change.
* @return a string representation of {@code this}
*/
@Override
public String toString() {
StringBuilder sb = new StringBuilder();
sb.append("[BasicGT: nMarkers=");
sb.append(nMarkers());
sb.append(" nSamples=");
sb.append(nSamples());
for (GTRec rec : recs) {
sb.append(Const.nl);
sb.append(rec);
}
sb.append(']');
return sb.toString();
}
}
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