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/*
* Copyright (C) 2014-2021 Brian L. Browning
*
* This file is part of Beagle
*
* Beagle is free software: you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* Beagle is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with this program. If not, see <http://www.gnu.org/licenses/>.
*/
package vcf;
import ints.IntArray;
import java.util.Arrays;
import java.util.stream.IntStream;
/**
* <p>Class {@code LowMafRefGTRec} represent represents phased, non-missing
* genotypes for a list of reference samples at a single marker.</p>
*
* <p>Class {@code LowMafRefGTRec} stores the haplotypes that carry each
* non-major allele.</p>
*
* <p>Instances of class {@code LowMemRefGTRec} are immutable.</p>
*
* @author Brian L. Browning {@code <browning@uw.edu>}
*/
public final class LowMafRefGTRec implements RefGTRec {
private final Marker marker;
private final Samples samples;
private final int nHaps;
private final int majorAllele;
private final int[][] hapIndices;
/**
* Constructs a new {@code LowMafRefGTRec} instance from the specified data.
*
* @param rec the phased, non-missing genotype data
* @throws NullPointerException if {@code rec == null}
*/
public LowMafRefGTRec(RefGTRec rec) {
this.hapIndices = rec.hapIndices();
int majAllele = 0;
while (hapIndices[majAllele]!=null) {
++majAllele;
}
this.marker = rec.marker();
this.samples = rec.samples();
this.nHaps = rec.size();
this.majorAllele = majAllele;
}
/**
* Constructs a new {@code LowMafRefGTRc} instance from the specified
* data.
*
* @param gtp a VCF record parser that extracts sample genotypes
* @throws IllegalArgumentException if the VCF record contains an
* unphased genotype or missing allele
* @throws IllegalArgumentException if a format error is detected in the
* VCF record
* @throws NullPointerException if {@code gtp == null}
*/
public LowMafRefGTRec(VcfRecGTParser gtp) {
this.marker = gtp.marker();
this.samples = gtp.samples();
this.nHaps = 2*gtp.nSamples();
this.hapIndices = gtp.nonMajRefIndices();
int majAl = -1;
for (int j=0; j<hapIndices.length; ++j) {
if (hapIndices[j]==null) {
majAl = j;
break;
}
}
this.majorAllele = majAl;
}
/**
* Constructs a new {@code LowMafRefGTRec} instance from the specified data.
* The specified {@code hapIndices} array is required to contain exactly one
* {@code null} element. The {@code null} element should be the major
* allele because this is most memory-efficient, but this requirement is not
* enforced. A haplotype index should be an element of only one array in
* {@code hapIndices}. If a haplotype index is an element of more than
* one array in {@code hapIndices}, it is assigned to the array with
* smallest index.
* @param marker the marker
* @param samples the samples
* @param hapIndices whose {@code j}-th element is a list of haplotypes
* sorted in increasing order that carry the {@code j}-th allele, or is
* {@code null}
*
* @throws IllegalArgumentException if the {@code (hapIndices} does
* not contain exactly one {@code null} element
* @throws IllegalArgumentException if any non-null element of
* {@code hapIndices} is not a sorted list of distinct haplotype indices
* between 0 (inclusive) and {@code 2*samples.size()} (exclusive)
* @throws IllegalArgumentException if
* {@code marker.nAlleles() != hapIndices.length}
* @throws NullPointerException if
* {@code marker == null || samples == null || hapIndices == null}
*/
public LowMafRefGTRec(Marker marker, Samples samples, int[][] hapIndices) {
this.marker = marker;
this.samples = samples;
this.nHaps = 2*samples.size();
this.majorAllele = checkIndicesAndReturnNullIndex(hapIndices, nHaps);
this.hapIndices = deepCopy(hapIndices);
}
static int checkIndicesAndReturnNullIndex(int[][] hapIndices, int nHaps) {
int majAllele = -1;
for (int j=0; j<hapIndices.length; ++j) {
if (hapIndices[j]==null) {
if (majAllele == -1) {
majAllele = j;
}
else {
throwArrayError();
}
}
else {
checkSorted(hapIndices[j], nHaps);
}
}
if (majAllele == -1) {
throwArrayError();
}
return majAllele;
}
private static void throwArrayError() {
throw new IllegalArgumentException("invalid array");
}
private static void checkSorted(int[] ia, int nHaps) {
if (ia.length>0 && (ia[0] < 0 || ia[ia.length - 1] >= nHaps)) {
throwArrayError();
}
for (int k=1; k<ia.length; ++k) {
if (ia[k-1] >= ia[k]) {
throwArrayError();
}
}
}
static int[][] deepCopy(int[][] ia) {
int[][] copy = new int[ia.length][];
for (int j=0; j<ia.length; ++j) {
if (ia[j]!=null) {
copy[j] = ia[j].clone();
}
}
return ia;
}
@Override
public int[][] hapIndices() {
return deepCopy(hapIndices);
}
@Override
public boolean isPhased(int sample) {
if (sample < 0 || sample >= this.samples().size()) {
throw new IndexOutOfBoundsException(String.valueOf(sample));
}
return true;
}
/**
* Returns {@code true}.
* @return {@code true}
*/
@Override
public boolean isPhased() {
return true;
}
@Override
public Samples samples() {
return samples;
}
@Override
public int size() {
return nHaps;
}
@Override
public Marker marker() {
return marker;
}
@Override
public int allele1(int sample) {
return get(sample<<1);
}
@Override
public int allele2(int sample) {
return get((sample<<1) | 0b1);
}
@Override
public int get(int hap) {
if (hap < 0 || hap >= nHaps) {
throw new IndexOutOfBoundsException(String.valueOf(hap));
}
for (int j=0; j<hapIndices.length; ++j) {
if (j != majorAllele) {
if (Arrays.binarySearch(hapIndices[j], hap) >= 0) {
return j;
}
}
}
return majorAllele;
}
@Override
public int[] alleles() {
int[] ia = IntStream.range(0, nHaps)
.map(h -> majorAllele)
.toArray();
for (int al=0; al<hapIndices.length; ++al) {
if (al != majorAllele) {
for (int h : hapIndices[al]) {
ia[h] = al;
}
}
}
return ia;
}
@Override
public boolean isAlleleCoded() {
return true;
}
@Override
public int majorAllele() {
return majorAllele;
}
@Override
public int[] alleleCounts() {
int[] alCnts = new int[marker.nAlleles()];
alCnts[majorAllele] = nHaps;
for (int j=0; j<alCnts.length; ++j) {
if (j!=majorAllele) {
int alCnt = hapIndices[j].length;
alCnts[j] = alCnt;
alCnts[majorAllele] -= alCnt;
}
}
return alCnts;
}
@Override
public int alleleCount(int allele) {
if (hapIndices[allele]==null) {
throw new IllegalArgumentException("major allele");
}
else {
return hapIndices[allele].length;
}
}
@Override
public int hapIndex(int allele, int copy) {
if (hapIndices[allele]==null) {
throw new IllegalArgumentException("major allele");
}
else {
return hapIndices[allele][copy];
}
}
@Override
public boolean isCarrier(int allele, int hap) {
return get(hap)==allele;
}
/**
* Returns the data represented by {@code this} as a VCF
* record with a GT format field. The returned VCF record
* will have missing QUAL and INFO fields, will have "PASS"
* in the filter field, and will have a GT format field.
* @return the data represented by {@code this} as a VCF
* record with a GT format field
*/
@Override
public String toString() {
return GTRec.toVcfRec(this);
}
@Override
public int nMaps() {
return 1;
}
@Override
public IntArray[] maps() {
return new IntArray[] {toIntArray()};
}
@Override
public IntArray map(int index) {
if (index!=0) {
throw new IndexOutOfBoundsException(String.valueOf(index));
}
return toIntArray();
}
private IntArray toIntArray() {
int[] ia = IntStream.range(0, nHaps)
.map(i -> majorAllele)
.toArray();
for (int al=0; al<hapIndices.length; ++al) {
if (hapIndices[al]!=null) {
for (int i : hapIndices[al]) {
ia[i] = al;
}
}
}
return IntArray.packedCreate(ia, hapIndices.length);
}
}
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