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/*
* Copyright (C) 2014-2021 Brian L. Browning
*
* This file is part of Beagle
*
* Beagle is free software: you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* Beagle is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with this program. If not, see <http://www.gnu.org/licenses/>.
*/
package vcf;
import ints.IntArray;
import java.util.Arrays;
import java.util.stream.IntStream;
/**
* <p>Class {@code SeqCodedRefGT} represents phased, non-missing
* genotypes for a list of reference samples at a single marker.
* Genotype emission probabilities are determined by the sample
* genotypes.
* </p>
* <p>Instances of class {@code SeqCodedRefGT} are immutable.
* </p>
*
* @author Brian L. Browning {@code <browning@uw.edu>}
*/
public class SeqCodedRefGTRec implements RefGTRec {
private final Marker marker;
private final Samples samples;
private final IntArray hapToSeq;
private final IntArray seqToAllele;
/**
* Creates a new {@code SeqCodedRefGT} instance with phased,
* non-missing genotypes from the specified marker, samples,
* and haplotype alleles. The contract for the constructed object
* is undefined if any element of {@code hapToSeq} is negative or
* greater than or equal to {@code seqToAllele.size()} or if any element
* of {@code seqToAllele} is negative or greater than or equal to
* {@code marker.nAlleles()}.
*
* @param marker the marker
* @param samples the samples
* @param hapToSeq an array whose {@code j}-th element is the index
* of the distinct allele sequence carried by the {@code j}-th haplotype
* @param seqToAllele an array whose {@code j}-th element is the marker
* allele carried by the {@code j}-th distinct allele sequence
*
* @throws IllegalArgumentException if
* {@code hapToSeq.size() != 2*samples.size()}
* @throws NullPointerException if any parameter is {@code null}
*/
public SeqCodedRefGTRec(Marker marker, Samples samples, IntArray hapToSeq,
IntArray seqToAllele) {
if (hapToSeq.size() != 2*samples.size()) {
throw new IllegalArgumentException("inconsistent data");
}
this.marker = marker;
this.samples = samples;
this.hapToSeq = hapToSeq;
this.seqToAllele = seqToAllele;
}
@Override
public boolean isPhased(int sample) {
if (sample < 0 || sample >= this.samples().size()) {
throw new IndexOutOfBoundsException(String.valueOf(sample));
}
return true;
}
/**
* Returns {@code true}.
* @return {@code true}
*/
@Override
public boolean isPhased() {
return true;
}
@Override
public Samples samples() {
return samples;
}
@Override
public int size() {
return hapToSeq.size();
}
@Override
public Marker marker() {
return marker;
}
@Override
public int[][] hapIndices() {
int[] alCnts = alleleCounts();
int majAllele = 0;
for (int al=1; al<alCnts.length; ++al) {
if (alCnts[al] > alCnts[majAllele]) {
majAllele = al;
}
}
int[][] hapIndices = new int[alCnts.length][];
for (int al=0; al<alCnts.length; ++al) {
if (al!=majAllele) {
hapIndices[al] = new int[alCnts[al]];
}
}
Arrays.fill(alCnts, 0);
for (int h=0, n=size(); h<n; ++h) {
int al = get(h);
if (al!=majAllele) {
hapIndices[al][alCnts[al]++] = h;
}
}
return hapIndices;
}
@Override
public boolean isAlleleCoded() {
return false;
}
@Override
public int majorAllele() {
return majorAllele(alleleCounts());
}
private int majorAllele(int[] alCnts) {
int majAl = 0;
for (int al=1; al<alCnts.length; ++al) {
if (alCnts[al]>alCnts[majAl]) {
majAl = al;
}
}
return majAl;
}
@Override
public int[] alleleCounts() {
int[] alCnts = new int[marker.nAlleles()];
for (int h=0, n=size(); h<n; ++h) {
++alCnts[get(h)];
}
return alCnts;
}
@Override
public int alleleCount(int allele) {
int[] alCnts = alleleCounts();
if (allele==majorAllele(alCnts)) {
throw new IllegalArgumentException("major allele");
}
else {
return alCnts[allele];
}
}
@Override
public int allele1(int sample) {
return seqToAllele.get(hapToSeq.get(sample<<1));
}
@Override
public int allele2(int sample) {
return seqToAllele.get(hapToSeq.get((sample<<1) | 0b1));
}
@Override
public int get(int hap) {
return seqToAllele.get(hapToSeq.get(hap));
}
@Override
public int[] alleles() {
return IntStream.range(0, hapToSeq.size())
.map(h -> get(h))
.toArray();
}
@Override
public int hapIndex(int allele, int copy) {
int[][] hapIndices = hapIndices();
if (hapIndices[allele]==null) {
throw new IllegalArgumentException("major allele");
}
else {
return hapIndices[allele][copy];
}
}
@Override
public boolean isCarrier(int allele, int hap) {
return get(hap)==allele;
}
/**
* Returns the data represented by {@code this} as a VCF
* record with a GT format field. The returned VCF record
* will have missing QUAL and INFO fields, will have "PASS"
* in the filter field, and will have a GT format field.
* @return the data represented by {@code this} as a VCF
* record with a GT format field
*/
@Override
public String toString() {
return GTRec.toVcfRec(this);
}
@Override
public int nMaps() {
return 2;
}
@Override
public IntArray[] maps() {
return new IntArray[] {hapToSeq, seqToAllele};
}
@Override
public IntArray map(int index) {
switch (index) {
case 0:
return hapToSeq;
case 1:
return seqToAllele;
default:
throw new IndexOutOfBoundsException(String.valueOf(index));
}
}
}
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