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/*
// Author: Shane Neph
// Date: Sun Mar 18 15:28:01 PDT 2012
*/
//
// BEDOPS
// Copyright (C) 2011-2022 Shane Neph, Scott Kuehn and Alex Reynolds
//
// This program is free software; you can redistribute it and/or modify
// it under the terms of the GNU General Public License as published by
// the Free Software Foundation; either version 2 of the License, or
// (at your option) any later version.
//
// This program is distributed in the hope that it will be useful,
// but WITHOUT ANY WARRANTY; without even the implied warranty of
// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
// GNU General Public License for more details.
//
// You should have received a copy of the GNU General Public License along
// with this program; if not, write to the Free Software Foundation, Inc.,
// 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301 USA.
//
#ifndef SPECIAL_BED_ITERATOR_HEADERS_STARCH_CHR_SPECIFIC_POOL_HPP
#define SPECIAL_BED_ITERATOR_HEADERS_STARCH_CHR_SPECIFIC_POOL_HPP
#include <cctype>
#include <cstddef>
#include <cstdlib>
#include <fstream>
#include <istream>
#include <iterator>
#include <limits>
#include <sstream>
#include <string>
#include <type_traits>
#include <vector>
#include <sys/stat.h>
#include "algorithm/bed/FindBedRange.hpp"
#include "algorithm/visitors/helpers/ProcessVisitorRow.hpp"
#include "data/bed/Bed.hpp"
#include "data/starch/starchApi.hpp"
#include "suite/BEDOPS.Constants.hpp"
#include "utility/ByLine.hpp"
#include "utility/Exception.hpp"
#include "utility/PooledMemory.hpp"
namespace Bed {
template <class BedType, std::size_t SZ=Bed::CHUNKSZ>
class bed_check_iterator;
template <class BedType, std::size_t SZ>
class bed_check_iterator<BedType*, SZ> {
public:
typedef Ext::UserError Exception;
typedef std::forward_iterator_tag iterator_category;
typedef BedType* value_type;
typedef std::ptrdiff_t difference_type;
typedef BedType** pointer;
typedef BedType*& reference;
static constexpr int nFields_ = BedType::NumFields;
static constexpr bool hasRest_ = BedType::UseRest;
bed_check_iterator() : fp_(std::cin), _M_ok(false), _M_value(0), fn_(""), cnt_(0),
lastChr_(""), lastRest_(""), lastStart_(1), lastEnd_(0), nestCheck_(false),
maxEnd_(0), chr_(""), isStarch_(false), all_(true), archive_(0), pool_(0)
{ /* */ }
bed_check_iterator(std::istream& is, const std::string& filename, Ext::PooledMemory<BedType, SZ>& p,
const std::string& chr = "all", bool nestCheck = false)
: fp_(is), _M_ok(fp_), _M_value(0), fn_(filename), cnt_(0), lastChr_(""), lastRest_(""), lastStart_(1),
lastEnd_(0), nestCheck_(nestCheck), maxEnd_(0), chr_(chr),
isStarch_(false), all_(chr_ == "all"),
archive_(0), pool_(&p) {
if ( !_M_ok )
return;
bool is_namedpipe = false;
if ( fn_ != "-" && fn_ != "stdin" ) {
struct stat st;
if ( stat(filename.c_str(), &st) == -1 )
throw(Exception("stat() failed on: " + fn_));
is_namedpipe = (S_ISFIFO(st.st_mode) != 0);
}
isStarch_ = (fp_ && !is_namedpipe && (&is != &std::cin) && starch::Starch::isStarch(fn_));
if ( isStarch_ ) // Starch constructor opens a stream for us
dynamic_cast<std::ifstream&>(fp_).close(); // isStarch_ ensures fp_ is open and it's not std::cin/named pipe
// compare pointers directly, to allow compilation with Clang/LLVM against C++11 standard
if ( (&fp_ == &std::cin || is_namedpipe) && !all_ ) { // only BED through stdin; chromosome-specific
// cannot 'jump' to chr_ -> stream through, line by line until we find it or eof
Ext::ByLine bl;
while ( (_M_ok = (fp_ && fp_ >> bl)) ) {
++cnt_;
while ( !check(bl) ) {
if ( fp_ >> bl )
++cnt_;
else { /* only headers found */
_M_ok = false;
_M_value = static_cast<BedType*>(0);
return;
}
} // while
if ( _M_value->chrom() == chr_ )
return;
pool_->release(_M_value);
_M_value = static_cast<BedType*>(0);
} // while
_M_value = static_cast<BedType*>(0);
return;
}
if ( isStarch_ ) {
const bool perLineUsage = true;
const bool noHeaders = false;
archive_ = new starch::Starch(fn_, noHeaders, perLineUsage, chr_);
_M_ok = archive_->getArchiveRecordIter();
if ( !_M_ok ) {
delete archive_;
archive_ = NULL;
} else {
std::string line;
_M_ok = get_starch(line); // let starchApi deal with headers
if ( _M_ok ) {
++cnt_;
check(line);
}
_M_ok = (_M_ok && static_cast<bool>(_M_value) &&
static_cast<bool>(archive_->getArchiveRecordIter()) &&
!archive_->isEOF());
}
} else if ( !all_ ) { // BED, chromosome-specific
// position fp_ to start of correct chromosome
FILE* tmpf = std::fopen(fn_.c_str(), "r");
if ( tmpf == NULL )
throw(Exception("Internal problem opening file: " + fn_));
std::fseek(tmpf, 0, SEEK_END); // apparently dangerous on some platforms in binary mode -> padded nulls;
const Bed::ByteOffset at_end = std::ftell(tmpf); // I'll assume msft is the problem until I know better
std::rewind(tmpf);
Bed::extract_details::TargetBedType* bt = new Bed::extract_details::TargetBedType(tmpf);
if ( bt->chrom() == chr_ ) { // first entry is correct chromosome
delete bt;
std::rewind(tmpf);
fp_.seekg(0, std::ios::beg);
Ext::ByLine bl;
if ( !(_M_ok && fp_ >> bl) )
_M_ok = false;
else {
++cnt_;
while ( !check(bl) ) {
if ( fp_ >> bl )
++cnt_;
else { /* only headers found */
_M_ok = false;
break;
}
} // while
}
_M_ok = (_M_ok && fp_ && !fp_.eof());
} else { // search for correct chromosome
delete bt;
std::rewind(tmpf);
const bool done = false;
std::vector<Bed::extract_details::TargetBedType*> v;
while ( !done ) {
bt = new Bed::extract_details::TargetBedType(tmpf);
bt->start(std::numeric_limits<Bed::CoordType>::max()-1);
bt->end(std::numeric_limits<Bed::CoordType>::max());
v.push_back(bt);
Visitors::Helpers::DoNothing nada;
std::pair<bool, Bed::ByteOffset> lbound;
lbound = find_bed_range(tmpf, v.begin(), v.end(), nada); // routine deletes bt for us
v.clear(); // bt already deleted
if ( lbound.first && lbound.second != at_end ) {
std::fseek(tmpf, lbound.second, SEEK_SET);
ByteOffset b = std::ftell(tmpf);
Bed::extract_details::QueryBedType q(tmpf);
std::fseek(tmpf, b, SEEK_SET);
if ( q.chrom() == chr_ ) {
fp_.seekg(b, std::ios::beg);
Ext::ByLine bl;
if ( !(_M_ok && fp_ >> bl) )
_M_ok = false;
else {
++cnt_;
while ( !check(bl) ) {
if ( fp_ >> bl )
++cnt_;
else { /* only headers found */
_M_value = static_cast<BedType*>(0);
_M_ok = false;
break;
}
} // while
}
_M_ok = (_M_ok && fp_ && !fp_.eof());
break;
}
}
else {
_M_value = static_cast<BedType*>(0);
_M_ok = false;
break;
}
} // while
}
std::fclose(tmpf);
} else { // BED, process everything
Ext::ByLine bl;
if ( !(_M_ok && fp_ >> bl) )
_M_ok = false;
else {
++cnt_;
while ( !check(bl) ) {
if ( fp_ >> bl )
++cnt_;
else { /* only headers found */
_M_ok = false;
break;
}
} // while
}
}
}
reference operator*() { return _M_value; }
pointer operator->() { return &(operator*()); }
bed_check_iterator& operator++() {
static Ext::ByLine bl;
if ( _M_ok ) {
if ( !isStarch_ ) { // bed
if ( (_M_ok = (fp_ && fp_ >> bl)) ) {
++cnt_;
if ( !check(bl) ) {
std::stringstream s;
s << cnt_;
throw(Exception("in " + fn_ + "\nHeader found but should be at top of file.\nSee row: " + s.str()));
} else if ( !all_ && (_M_value->chrom() != chr_) ) {
pool_->release(_M_value);
_M_value = static_cast<BedType*>(0);
_M_ok = false;
}
}
} else { // starch
_M_ok = get_starch(bl);
if ( _M_ok ) {
++cnt_;
check(bl);
}
_M_ok = (_M_ok && static_cast<bool>(_M_value) &&
static_cast<bool>(archive_->getArchiveRecordIter()) &&
!archive_->isEOF());
}
}
return *this;
}
bed_check_iterator operator++(int) {
auto __tmp = *this;
static Ext::ByLine bl;
if ( _M_ok ) {
if ( !isStarch_ ) { // bed
if ( (_M_ok = (fp_ && fp_ >> bl)) ) {
++cnt_;
if ( !check(bl) ) {
std::stringstream s;
s << cnt_;
throw(Exception("in " + fn_ + "\nHeader found but should be at top of file.\nSee row: " + s.str()));
} else if ( !all_ && (_M_value->chrom() != chr_ ) ) {
pool_->release(_M_value);
_M_value = static_cast<BedType*>(0);
_M_ok = false;
}
}
} else { // starch
_M_ok = get_starch(bl);
if ( _M_ok ) {
++cnt_;
check(bl);
}
_M_ok = (_M_ok && static_cast<bool>(_M_value) &&
static_cast<bool>(archive_->getArchiveRecordIter()) &&
!archive_->isEOF());
}
}
return __tmp;
}
Ext::PooledMemory<BedType, SZ>& get_pool() { return *pool_; }
void clean() {
if ( archive_ )
delete archive_;
}
bool _M_equal(const bed_check_iterator& __x) const
{ return ( (_M_ok == __x._M_ok) && (!_M_ok || &fp_ == &__x.fp_) ); }
bool operator=(const bed_check_iterator& b);
bool has_nested() const { /* only known for Starch archives */
if ( isStarch_ )
return archive_->getAllChromosomesHaveNestedElement();
return true; // assumption for BED
}
protected:
std::string lowerstr(const std::string& s) {
std::string t(s);
for ( std::size_t i = 0; i < t.size(); ++i )
t[i] = static_cast<char>(std::tolower(t[i]));
return t;
}
bool isUCSCheader(const std::string& bl) {
std::string tmp = lowerstr(bl);
return (tmp == "browser" || tmp == "track");
}
bool get_starch(std::string& line) {
if ( archive_ == NULL || !archive_->extractBEDLine(line) )
return false;
return !line.empty();
}
bool check(const std::string& bl) {
static std::string msg = "";
static int cmp = 0;
msg.clear();
if ( bl.empty() )
msg = "Empty line found.";
else if ( isUCSCheader(bl) )
return false;
// Check chromosome
std::string::size_type marker = 0, sz = bl.size();
while ( msg.empty() && marker < sz ) {
if ( bl[marker] == ' ' ) {
if ( isUCSCheader(bl.substr(0, marker)) )
return false;
msg = "First column should not have spaces. Consider 'chr1' vs. 'chr1 '. These are different names.\nsort-bed can correct this for you.";
}
else if ( 0 == marker && bl[marker] == '@' ) {
return false; // SAM format header supported by starch
}
else if ( 0 == marker && bl[marker] == '#' ) {
return false; // VCF format header supported by starch
}
else if ( bl[marker] == '\t' ) {
if ( 0 == marker )
msg = "First column name should not start with a tab.";
else {
if ( isUCSCheader(bl.substr(0, marker)) )
return false;
break;
}
}
++marker;
} // while
if ( msg.empty() ) {
if ( sz <= marker )
msg = "No tabs found in BED row.";
else if ( marker > Bed::MAXCHROMSIZE ) { // marker is 0-based; but points to tab after chromosome name
msg = "Chromosome name does not fit in MAXCHROMSIZE chars.\nIncrease TOKEN_CHR_MAX_LENGTH in BEDOPS.Constants.hpp and recompile BEDOPS.";
std::stringstream a, b;
a << Bed::MAXCHROMSIZE;
b << bl.substr(0, marker).size();
msg += "\nMAXCHROMSIZE = " + a.str();
msg += "; Size given = " + b.str();
}
else
++marker; // increment passed tab
}
// Check start coordinate
static std::string::size_type pos = marker;
pos = marker;
while ( msg.empty() && marker < sz ) {
if ( !std::isdigit(bl[marker]) ) {
if ( bl[marker] == '\t' && pos != marker )
break;
else if ( bl[marker] == '\t' )
msg += "Two or more consecutive tabs. No start coordinate.";
else if ( bl[marker] == '-' && marker == pos )
msg += "Start coordinate cannot be < 0: ";
else if ( bl[marker] == ' ' )
msg += "Start coordinate may not contain a space: ";
else {
msg = "Start coordinate contains non-numeric character: ";
msg += bl[marker];
}
}
++marker;
} // while
if ( msg.empty() ) {
if ( sz <= marker )
msg = "No tabs after start coordinate.";
else {
if ( marker-pos > MAX_DEC_INTEGERS )
msg = "Sanity check failure - start coordinate has too many digits as defined by MAX_DEC_INTEGERS in BEDOPS.Constants.hpp";
else if ( std::atof(bl.substr(pos, marker-pos).c_str()) > double(MAX_COORD_VALUE) )
msg = "Sanity check failure - start coordinate is more than allowed by MAX_COORD_VALUE in BEDOPS.Constants.hpp";
else if ( std::atof(bl.substr(pos, marker-pos).c_str()) > std::numeric_limits<Bed::CoordType>::max() )
msg = "Start coordinate exceeds limits of a Bed::CoordType on your system.";
else
++marker; // increment passed tab
}
}
// Check end coordinate
pos = marker;
auto restMarker = marker;
while ( msg.empty() && marker < sz ) {
if ( !std::isdigit(bl[marker]) ) {
if ( bl[marker] == '\t' && pos != marker )
break;
else if ( bl[marker] == '\t' )
msg += "Two or more consecutive tabs. No end coordinate.";
else if ( bl[marker] == '-' && marker == pos )
msg += "End coordinate cannot be < 0: ";
else if ( bl[marker] == ' ' )
msg += "End coordinate may not contain a space: ";
else {
msg = "End coordinate contains non-numeric character: ";
msg += bl[marker];
}
}
++marker;
} // while
if ( msg.empty() ) {
if ( sz <= marker && nFields_ > 3 ) {
std::stringstream con; con << nFields_;
msg = "Only 3 columns given. Require at least " + con.str();
}
else {
if ( marker-pos > MAX_DEC_INTEGERS )
msg = "Sanity check failure - start coordinate has too many digits as defined by MAX_DEC_INTEGERS in BEDOPS.Constants.hpp";
else if ( std::atof(bl.substr(pos, marker-pos).c_str()) > double(MAX_COORD_VALUE) )
msg = "Sanity check failure - start coordinate is more than allowed by MAX_COORD_VALUE in BEDOPS.Constants.hpp";
else if ( std::atof(bl.substr(pos, marker-pos).c_str()) > std::numeric_limits<Bed::CoordType>::max() )
msg = "End coordinate exceeds limits of an Bed::CoordType on your system.";
else
++marker; // increment passed tab
}
}
std::size_t idsz = 0, measurementsz = 0;
if ( nFields_ > 3 ) { // check ID field
pos = marker;
while ( msg.empty() && marker < sz ) {
if ( bl[marker] == '\t' && pos != marker )
break;
else if ( bl[marker] == '\t' )
msg += "Two or more consecutive tabs. No ID field.";
else if ( bl[marker] == ' ' )
msg += "ID field may not contain a space.";
++marker;
} // while
if ( msg.empty() ) {
if ( sz <= marker && nFields_ > 4 ) {
std::stringstream con; con << nFields_;
msg = "Only 4 columns given. Require at least " + con.str();
}
else if ( pos == marker )
msg = "Fourth (id) column is empty.";
else if ( marker-pos > Bed::MAXIDSIZE ) { // marker points at the tab after ID field, and it's 0-based
msg = "ID field does not fit in MAXCHROMSIZE chars.\nIncrease TOKEN_ID_MAX_LENGTH in BEDOPS.Constants.hpp and recompile BEDOPS.";
std::stringstream a, b;
a << Bed::MAXIDSIZE;
b << bl.substr(pos, marker-pos).size();
msg += "\nMAXIDSIZE = " + a.str();
msg += "; Size given = " + b.str();
}
else {
++marker; // increment passed tab
idsz = (marker-pos); // include tab
}
}
if ( nFields_ > 4 ) { // check measurement column
pos = marker;
static int decimalCount = 0;
static int expCount = 0;
static std::size_t expPos = 0;
static int minusCount = 0;
static std::size_t minusPos = 0;
decimalCount = 0;
expCount = 0;
expPos = 0;
minusCount = 0;
minusPos = 0;
while ( msg.empty() && marker < sz ) {
if ( !std::isdigit(bl[marker]) ) {
if ( bl[marker] == '\t' && pos != marker )
break;
else if ( bl[marker] == '\t' )
msg = "Two or more consecutive tabs. No measurement given.";
else if ( bl[marker] == '.' ) {
if ( ++decimalCount > 1 )
msg = "More than one decimal point in measurement field.";
else if ( expCount > 0 )
msg = "Bad decimal point - part of exponent.";
}
else if ( bl[marker] == 'e' || bl[marker] == 'E' ) {
if ( ++expCount > 1 )
msg = "Measurement value contains non-numeric character (multiple 'E' or 'e' characters detected).";
expPos = marker;
}
else if ( bl[marker] == ' ' )
msg = "Measurement value may not contain a space.";
else if ( bl[marker] == '-' || bl[marker] == '+' ) {
if ( marker != pos && expCount < 1 )
msg = "Measurement value has '-' or '+' in wrong place.";
if ( msg.empty() && marker != pos ) {
if ( ++minusCount > 1 )
msg = "Measurement value has multiple '-' and/or '+' characters.";
else if ( expPos + 1 != marker )
msg = "Measurement value has bad '-' in the exponent.";
minusPos = marker;
}
}
else {
msg = "Measurement value contains non-numeric character: ";
msg += bl[marker];
}
}
++marker;
} // while
if ( msg.empty() ) {
if ( sz <= marker && nFields_ > 5 ) {
std::stringstream con; con << nFields_;
msg += "Only 5 columns given. Require at least " + con.str();
}
else if ( pos == marker )
msg = "Fifth (measure) column is empty.";
else if ( minusPos > 0 && minusPos + 1 == marker )
msg = "Measurement value ends with a '-'.";
else {
++marker; // increment passed tab
measurementsz = (marker-pos); // include tab
}
}
if ( nFields_ > 5 ) { // check strand column
pos = marker;
while ( msg.empty() && marker < sz ) {
if ( bl[marker] != '+' && bl[marker] != '-' ) {
if ( bl[marker] == '\t' && pos != marker )
break;
else if ( bl[marker] == '\t' )
msg += "Two or more consecutive tabs. No strand information given.";
else {
msg = "Strand (6th) column must be '+' or '-' (with no spaces). Received: ";
msg += bl[marker];
msg += "\nsort-bed can correct this for you.";
}
} else if ( marker != pos ) {
msg += "Two or more consecutive '+' or '-'s detected.";
}
++marker;
} // while
}
if ( msg.empty() ) {
if ( pos == marker )
msg = "Sixth (strand) column is empty.";
else
++marker; // increment passed tab.
}
}
}
if ( msg.empty() && hasRest_ && marker <= sz && (sz - marker + idsz + measurementsz) > Bed::MAXRESTSIZE ) { // idsz/measurementsz for fullrest_
msg = "The 'rest' of the input row (everything beyond the first 3";
std::stringstream a, b;
a << Bed::MAXRESTSIZE;
b << bl.substr(marker).size();
msg += " fields) cannot fit into MAXRESTSIZE chars.\nIncrease TOKEN_REST_MAX_LENGTH in BEDOPS.Constants.hpp and recompile BEDOPS.";
msg += "\nMAXRESTSIZE = " + a.str();
msg += "; Size given = " + b.str();
}
if ( !msg.empty() ) {
std::stringstream s;
s << cnt_;
throw(Exception("in " + fn_ + "\n" + msg + "\nSee row: " + s.str()));
}
_M_value = pool_->construct(bl);
if ( msg.empty() && !lastChr_.empty() ) {
cmp = std::strcmp(_M_value->chrom(), lastChr_.c_str());
if ( cmp < 0 )
msg = "Bed file not properly sorted by first column.";
else if ( cmp == 0 ) {
if ( _M_value->start() < lastStart_ )
msg = "Bed file not properly sorted by start coordinates.";
else if ( _M_value->start() == lastStart_ ) {
if ( _M_value->end() < lastEnd_ )
msg = "Bed file not properly sorted by end coordinates when start coordinates are identical.";
else if ( hasRest_ && _M_value->end() == lastEnd_ ) {
if ( std::strcmp(bl.substr(restMarker).c_str(), lastRest_.c_str()) < 0 )
msg = "Bed file not sorted by information following the 3rd column (columns 1-3 equal to previous row).";
}
}
if ( msg.empty() && nestCheck_ ) { // _M_value->start() > lastStart_
if ( _M_value->end() < maxEnd_ )
msg = "Fully nested component found.";
}
}
}
if ( msg.empty() && _M_value->end() <= _M_value->start() )
msg = "End coordinates must be greater than start coordinates.";
if ( !msg.empty() ) {
std::stringstream s;
s << cnt_;
throw(Exception("in " + fn_ + "\n" + msg + "\nSee row: " + s.str()));
}
lastChr_ = _M_value->chrom();
lastStart_ = _M_value->start();
lastEnd_ = _M_value->end();
lastRest_ = bl.substr(restMarker);
maxEnd_ = lastEnd_;
return true;
}
private:
std::istream& fp_;
bool _M_ok;
BedType* _M_value;
std::string fn_;
Bed::CoordType cnt_;
std::string lastChr_, lastRest_;
Bed::CoordType lastStart_, lastEnd_;
bool allowHeaders_;
bool nestCheck_;
Bed::CoordType maxEnd_;
std::string chr_;
bool isStarch_;
const bool all_;
starch::Starch* archive_;
Ext::PooledMemory<BedType, SZ>* pool_;
};
template <class BedType, std::size_t Sz>
inline bool
operator==(const bed_check_iterator<BedType, Sz>& __x,
const bed_check_iterator<BedType, Sz>& __y) {
return __x._M_equal(__y);
}
template <class BedType, std::size_t Sz>
inline bool
operator!=(const bed_check_iterator<BedType, Sz>& __x,
const bed_check_iterator<BedType, Sz>& __y) {
return !__x._M_equal(__y);
}
} // namespace Bed
#endif // SPECIAL_BED_ITERATOR_HEADERS_STARCH_CHR_SPECIFIC_POOL_HPP
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