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#include<algorithm>
#include<cstdlib>
#include<vector>
using namespace std;
#include "PosteriorSamples.h"
#include "FileHeader.h"
#include "misc.h"
#include "common.h"
#define Sof(x) (long)x.size()
#define SS second
#define FF first
#define MINUS_INF -47
#define PLUS_INF 1e10
void PosteriorSamples::clear(){
N=0;
M=0;
norm = 1.0;
failed=true;
transposed=true;
areLogged=false;
}
bool PosteriorSamples::open(string fileName){
if(samplesF.is_open())samplesF.close();
samplesF.open(fileName.c_str());
if(!samplesF.is_open()){
error("PosterioSamples: File open failed: %s\n",(fileName).c_str());
failed=true;
return false;
}
return true;
}
bool PosteriorSamples::initSet(long *m,long *n, string fileName){
failed=false;
if(! open(fileName))return false;
FileHeader fh(&samplesF);
if(!fh.samplesHeader(n,m,&transposed,&areLogged)){
error("PosteriorSamples: File header reading failed.\n");
failed=true;
return false;
}
N=*n;
M=*m;
return read();
}
bool PosteriorSamples::read(){
if(failed)return false;
if(transposed){
lines=vector<long>(M,-1);
lines[0]=samplesF.tellg();
}else{
if(N*M > PS_maxStoredSamples){
error("PosteriorSamples: Too many samples to store,use trasposed file.\n");
failed=true;
return false;
}
samples.resize(M,vector<double>(N,0));
for(long i=0;i<N;i++)
for(long j=0;j<M;j++)
samplesF>>samples[j][i];
if(!samplesF.good()){
failed=true;
return false;
}
}
return true;
}
bool PosteriorSamples::getTranscript(long tr,vector<double> &trSamples){
if((tr>=M)||(failed))return false;
string str;
bool good=true;
if(Sof(trSamples)!=N)trSamples.resize(N);
if(transposed){
long i;
if(lines[tr]==-1){
for(i=0;lines[i+1]!=-1;i++);
samplesF.seekg(lines[i]);
while((samplesF.good())&&(i<tr)){
i++;
samplesF.ignore(10000000,'\n');
lines[i]=samplesF.tellg();
}
}else{
samplesF.seekg(lines[tr]);
}
for(i=0;(i<N)&&(samplesF.good());i++){
samplesF>>trSamples[i];
trSamples[i] *= norm;
if(samplesF.eof())break;
if(samplesF.fail()){
samplesF.clear();
samplesF.seekg(-1,ios::cur);
samplesF>>str;
if(ns_misc::toLower(str)=="-inf")trSamples[i]=MINUS_INF;
else if(ns_misc::toLower(str)=="nan")trSamples[i]=PLUS_INF;
else error("PosteriorSamples: Unknown value: %s in [tr:%ld,pos:%ld]\n",(str).c_str(),tr,i);
good=false;
}
}
if(i!=N){
good=false;
error("PosteriorSamples: Reading failed at position: [tr:%ld,pos:%ld]\n",tr,i);
}
}else{
trSamples = samples[tr];
if(norm!=1.0){
for(long i=0;i<N;i++)trSamples[i] *= norm;
}
}
return good;
}
void PosteriorSamples::close(){
samplesF.close();
failed=true;
}
Conditions::Conditions(){
mapping=false;
CN=0;
C=0;
}
long Conditions::getIndex(long max){
return rand() % max;
}
long Conditions::getRC(long c) const {
if(c>C)return -1;
return cIndex[c].SS;
}
bool Conditions::init(string trFileName, vector<string> filesGot, long *m, long *n){
long c;
return init(trFileName,filesGot,&c,m,n);
}
bool Conditions::init(string trFileName, vector<string> filesGot, long *c, long *m, long *n){
long i,j,x,colN;
bool sameMs=true;
vector<string> files;
cIndex.resize(1,pair<long,long>(0,0));
for(i=0;i<Sof(filesGot);i++){
if(filesGot[i]=="C"){
if((cIndex.end()-1)->SS!=0){
cIndex.push_back(pair<long,long>(Sof(files),0));
}
}else{
(cIndex.end()-1)->SS++;
files.push_back(filesGot[i]);
}
}
if((cIndex.end()-1)->SS==0){
cIndex.pop_back();
}
C = Sof(cIndex);
*c = C;
CN = Sof(files);
samples.resize(CN);
Ms.resize(CN);
Ns.resize(CN);
if(! samples[0].initSet(&Ms[0],&Ns[0],files[0])){
error("Conditions: file %s failed to open.\n",(files[0]).c_str());
return false;
}
areLogged = samples[0].logged();
N=Ns[0];
M=Ms[0];
for(i=1;i<CN;i++){
if(! samples[i].initSet(&Ms[i],&Ns[i],files[i])){
error("Conditions: file %s failed to open.\n",(files[i]).c_str());
return false;
}
if(areLogged != samples[i].logged()){
error("Conditions: Problem reading %s: some samples are logged and some are not.\n",(files[i]).c_str());
return false;
}
if(M!=Ms[i]){
sameMs=false;
}
if(N>Ns[i])N=Ns[i];
}
*n=N;
ifstream trFile(trFileName.c_str());
if(! trFile.is_open()){
if(sameMs){
M=Ms[0];
*m=M;
mapping = false;
return true;
}else{
error("Conditions: Different number of transcripts and missing transcript-join file\n");
return false;
}
}else{
FileHeader fh(&trFile);
if((!fh.transcriptsHeader(&M,&colN))||(M==0)||(colN<CN+1)){
error("Conditions: Wrong transcript join descriptor file - m: %ld colN: %ld\n",M,colN);
return false;
}
*m=M;
trMap.resize(M,vector<long>(CN));
for(i=0;i<M;i++){
trFile>>x;
for(j=0;j<colN;j++)
if(j<CN)trFile >> trMap[i][j];
else trFile >> x;
}
trFile.close();
sort(trMap.begin(),trMap.end());
mapping=true;
return true;
}
return false;
}
bool Conditions::setNorm(vector<double> norms){
if((long)norms.size()!=CN){
error("Conditions: The number of normalization constants does not match number of experiments (files with samples).\n");
return false;
}
for(long i=0;i<CN;i++){
samples[i].setNorm(norms[i]);
}
return true;
}
bool Conditions::getTranscript(long cond, long rep, long tr, vector<double> &trSamples){
if((cond>C)||(rep>cIndex[cond].SS)){
trSamples.clear();
return false;
}
return getTranscript(rep+cIndex[cond].FF, tr, trSamples);
}
bool Conditions::getTranscript(long cond, long tr, vector<double> &trSamples){
bool status=false;
static vector<double> tmpSamples;
if(cond>=CN){
error("Conditions: Wrong condition request.\n");
return false;
}
if(tr>=M){
error("Conitions: Wrong transcript request.\n");
return false;
}
if(mapping) tr = trMap[tr][cond];
if(N != Ns[cond]){
status = samples[cond].getTranscript(tr, tmpSamples);
if(Sof(trSamples) != N)trSamples.resize(N);
for(long i=0;i<N;i++)trSamples[i] = tmpSamples[ getIndex(Ns[cond]) ];
}else{
status = samples[cond].getTranscript(tr, trSamples);
}
return status;
}
bool Conditions::getTranscript(long cond, long tr, vector<double> &trSamples, long samplesN){
bool status=false;
static vector<double> tmpSamples;
if(cond>=CN){
error("Conditions: Wrong condition request.\n");
return false;
}
if(tr>=M){
error("Conitions: Wrong transcript request.\n");
return false;
}
if(samplesN > Ns[cond]){
error("Conitions: Wrong not enough samples.\n");
return false;
}
if(samplesN <1){
error("Conitions: Wrong number of samples.\n");
return false;
}
if(mapping)tr=trMap[tr][cond];
if(samplesN != Ns[cond]){
status = samples[cond].getTranscript(tr, tmpSamples);
if(Sof(trSamples) != samplesN)trSamples.resize(samplesN);
for(long i=0;i<samplesN;i++)
trSamples[i] = tmpSamples[ getIndex(Ns[cond]) ];
}else{
status = samples[cond].getTranscript(tr, trSamples);
}
return status;
}
void Conditions::close(){
for(long i=0;i<CN;i++){
samples[i].close();
}
cIndex.clear();
}
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