Summary: A bioinformatics toolkit for processing high-throughput lymphocyte receptor sequencing data.
Author: Namita Gupta, Jason Anthony Vander Heiden
License: Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
Description: Change-O - Repertoire clonal assignment toolkit
Change-O is a collection of tools for processing the output of V(D)J alignment
tools, assigning clonal clusters to immunoglobulin (Ig) sequences, and
reconstructing germline sequences.
Dramatic improvements in high-throughput sequencing technologies now enable
large-scale characterization of Ig repertoires, defined as the collection of
trans-membrane antigen-receptor proteins located on the surface of B cells and
T cells. Change-O is a suite of utilities to facilitate advanced analysis of
Ig and TCR sequences following germline segment assignment. Change-O
handles output from IMGT/HighV-QUEST and IgBLAST, and provides a wide variety of
clustering methods for assigning clonal groups to Ig sequences. Record sorting,
grouping, and various database manipulation operations are also included.
Keywords: bioinformatics,sequencing,immunology,adaptive immunity,immunoglobulin,AIRR-seq,Rep-Seq,B cell repertoire analysis,adaptive immune receptor repertoires
Classifier: Development Status :: 4 - Beta
Classifier: Environment :: Console
Classifier: Intended Audience :: Science/Research
Classifier: Natural Language :: English
Classifier: Operating System :: OS Independent
Classifier: Programming Language :: Python :: 3.4
Classifier: Topic :: Scientific/Engineering :: Bio-Informatics