File: mcmrbias.cxx

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/*
//
//  Copyright 1997-2012 Torsten Rohlfing
//
//  Copyright 2004-2013 SRI International
//
//  This file is part of the Computational Morphometry Toolkit.
//
//  http://www.nitrc.org/projects/cmtk/
//
//  The Computational Morphometry Toolkit is free software: you can
//  redistribute it and/or modify it under the terms of the GNU General Public
//  License as published by the Free Software Foundation, either version 3 of
//  the License, or (at your option) any later version.
//
//  The Computational Morphometry Toolkit is distributed in the hope that it
//  will be useful, but WITHOUT ANY WARRANTY; without even the implied
//  warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
//  GNU General Public License for more details.
//
//  You should have received a copy of the GNU General Public License along
//  with the Computational Morphometry Toolkit.  If not, see
//  <http://www.gnu.org/licenses/>.
//
//  $Revision: 3977 $
//
//  $LastChangedDate: 2012-03-06 15:30:28 -0800 (Tue, 06 Mar 2012) $
//
//  $LastChangedBy: torstenrohlfing $
//
*/

#include <cmtkconfig.h>

#include <System/cmtkCommandLine.h>
#include <System/cmtkDebugOutput.h>
#include <System/cmtkExitException.h>
#include <System/cmtkConsole.h>
#include <System/cmtkProgressConsole.h>

#include <Base/cmtkUniformVolume.h>
#include <Base/cmtkTypedArrayNoiseEstimatorNaiveGaussian.h>

#include <IO/cmtkVolumeIO.h>

#include <Registration/cmtkBestDirectionOptimizer.h>
#include <Segmentation/cmtkMultiChannelEntropyMinimizationIntensityCorrectionFunctional.h>

#include <math.h>
#include <vector>
#include <algorithm>

#ifdef CMTK_USE_SQLITE
#  include <Registration/cmtkImageXformDB.h>
#endif

const char* ImportBiasFieldAdd = NULL;
const char* ImportBiasFieldMul = NULL;

const char* FNameBiasFieldAdd = NULL;
const char* FNameBiasFieldMul = NULL;

cmtk::Types::DataItem PaddingValue = 0;
bool PaddingFlag = false;

float ThresholdForegroundMin = -FLT_MAX;
float ThresholdForegroundMax = FLT_MAX;
bool ThresholdForegroundFlag = false;
bool ThresholdAuto = false;
const char* FNameMaskImage = NULL;

bool UseSamplingDensity = false;
float SamplingDensity = 1.0;

unsigned int NumberOfHistogramBins = 256;

const char* FNameInputImage = NULL;
const char* FNameOutputImage = NULL;
bool OutputFloatImage = false;

int PolynomialDegreeAdd = 0;
int PolynomialDegreeMul = 2;
bool IncrementalPolynomials = false;

cmtk::Types::Coordinate StepMax = 1.0;
cmtk::Types::Coordinate StepMin = 0.1;

bool LogIntensities = false;

#ifdef CMTK_USE_SQLITE
const char* updateDB = NULL;
#endif

int
doMain( const int argc, const char *argv[] )
{
  try
    {
    cmtk::CommandLine cl( cmtk::CommandLine::PROPS_XML );
    cl.SetProgramInfo( cmtk::CommandLine::PRG_TITLE, "Multi-Channel MR Image Intensity Bias Field Correction" );
    cl.SetProgramInfo( cmtk::CommandLine::PRG_DESCR, "This program corrects intensity inhomogeneity artifacts in multiple-channel MR images simultaneously using a bias field estimated via joint and marginal entropy minimization." );
    cl.SetProgramInfo( cmtk::CommandLine::PRG_CATEG, "CMTK.Artifact Correction" );

    typedef cmtk::CommandLine::Key Key;
    cl.BeginGroup( "Bias Field", "Bias Field Parameterization" );
    cl.AddOption( Key( 'A', "degree-add" ), &PolynomialDegreeAdd, "Polynomial degree for additive correction." );
    cl.AddOption( Key( 'M', "degree-mul" ), &PolynomialDegreeMul, "Polynomial degree for multiplicative correction." );
    cl.AddSwitch( Key( 'I', "incremental" ), &IncrementalPolynomials, true, "Incrementally increase polynomial degrees." );
    cl.EndGroup();

    cl.BeginGroup( "Preprocessing", "Input Image Preprocessing" );
    cl.AddOption( Key( "set-padding-value" ), &PaddingValue, "Set padding value for input intensity image. Pixels with this value will be ignored.", &PaddingFlag );
    cl.AddOption( Key( 'm', "mask" ), &FNameMaskImage, "Binary mask image filename." )->SetProperties( cmtk::CommandLine::PROPS_IMAGE | cmtk::CommandLine::PROPS_LABELS );
    cl.AddOption( Key( 't', "thresh-min" ), &ThresholdForegroundMin, "Minimum intensity threshold for image foreground.", &ThresholdForegroundFlag );
    cl.AddOption( Key( 'T', "thresh-max" ), &ThresholdForegroundMax, "Minimum intensity threshold for image foreground.", &ThresholdForegroundFlag );
    cl.AddSwitch( Key( "thresh-auto" ), &ThresholdAuto, true, "Automatic minimum intensity threshold selection for image foreground using an estimate of image noise level." );
    cl.EndGroup();

    cl.BeginGroup( "Entropy Estimation", "Entropy Estimation Settings" )->SetProperties( cmtk::CommandLine::PROPS_ADVANCED );
    cl.AddSwitch( Key( 'L', "log-intensities" ), &LogIntensities, true, "Use log intensities for entropy estimation." );
    cl.AddOption( Key( 's', "sampling-density" ), &SamplingDensity, "Image sampling density to use only subset of image pixels", &UseSamplingDensity );
    cl.AddOption( Key( 'n', "num-bins" ), &NumberOfHistogramBins, "Number of histogram bins for entropy estimation" );
    cl.EndGroup();

    cl.BeginGroup( "Optimization", "Optimization Algorithm Settings" )->SetProperties( cmtk::CommandLine::PROPS_ADVANCED );;
    cl.AddOption( Key( "step-max" ), &StepMax, "Maximum (initial) search step size." );
    cl.AddOption( Key( "step-min" ), &StepMin, "Minimum (final) search step size." );
    cl.EndGroup();

    cl.BeginGroup( "I/O", "Input and Output Options" )->SetProperties( cmtk::CommandLine::PROPS_ADVANCED );;
    cl.AddOption( Key( "import-bias-add" ), &ImportBiasFieldAdd, "Import additive bias field (disables optimization)." )->SetProperties( cmtk::CommandLine::PROPS_IMAGE );
    cl.AddOption( Key( "import-bias-mul" ), &ImportBiasFieldMul, "Import multiplicative bias field (disables optimization)." )->SetProperties( cmtk::CommandLine::PROPS_IMAGE );
    cl.AddOption( Key( "write-bias-add" ), &FNameBiasFieldAdd, "File name for output of additive bias field." )->SetProperties( cmtk::CommandLine::PROPS_IMAGE | cmtk::CommandLine::PROPS_OUTPUT );
    cl.AddOption( Key( "write-bias-mul" ), &FNameBiasFieldMul, "File name for output of multiplicative bias field." )->SetProperties( cmtk::CommandLine::PROPS_IMAGE | cmtk::CommandLine::PROPS_OUTPUT );
    cl.AddSwitch( Key( 'F', "write-float" ), &OutputFloatImage, true, "Write output image with floating point pixel data. If this is not given, the input data type is used." );
    cl.EndGroup();
    
#ifdef CMTK_USE_SQLITE
    cl.BeginGroup( "Database", "Image/Transformation Database" );
    cl.AddOption( Key( "db" ), &updateDB, "Path to image/transformation database that should be updated with the newly created image." );
    cl.EndGroup();
#endif

    cl.AddParameter( &FNameInputImage, "InputImage", "Input image path" )->SetProperties( cmtk::CommandLine::PROPS_IMAGE );
    cl.AddParameter( &FNameOutputImage, "OutputImage", "Output image path" )->SetProperties( cmtk::CommandLine::PROPS_IMAGE | cmtk::CommandLine::PROPS_OUTPUT );

    cl.Parse( argc, argv );
    }
  catch ( const cmtk::CommandLine::Exception& e )
    {
    cmtk::StdErr << e << "\n";
    throw cmtk::ExitException( 1 );
    }

  // Instantiate programm progress indicator.
  cmtk::ProgressConsole progressIndicator( "Intensity Bias Field Correction" );

  cmtk::UniformVolume::SmartPtr inputImage( cmtk::VolumeIO::ReadOriented( FNameInputImage ) );

  if ( PaddingFlag )
    {
    inputImage->GetData()->SetPaddingValue( PaddingValue );
    }
  
  cmtk::UniformVolume::SmartPtr maskImage;
  if ( FNameMaskImage )
    {
    maskImage = cmtk::UniformVolume::SmartPtr( cmtk::VolumeIO::ReadOriented( FNameMaskImage ) );
    if ( ! maskImage || ! maskImage->GetData() )
      {
      cmtk::StdErr << "ERROR: Could not read mask image " << FNameMaskImage << "\n";
      throw cmtk::ExitException( 1 );
      }
    }
  else
    {
    if ( ThresholdAuto )
      {
      ThresholdForegroundMin = static_cast<float>( cmtk::TypedArrayNoiseEstimatorNaiveGaussian( *(inputImage->GetData()) ).GetNoiseThreshold() );
      ThresholdForegroundFlag = true;

      cmtk::DebugOutput( 1 ) << "INFO: estimated foreground threshold from noise level as " << ThresholdForegroundMin << "\n";
      }
    
    if ( ThresholdForegroundFlag )
      {
      maskImage = cmtk::UniformVolume::SmartPtr( inputImage->Clone( true /*copyData*/ ) );
      maskImage->GetData()->SetPaddingValue( 0.0 );
      maskImage->GetData()->ThresholdToPadding( cmtk::Types::DataItemRange( ThresholdForegroundMin, ThresholdForegroundMax ) );
      }  
    }

  typedef cmtk::EntropyMinimizationIntensityCorrectionFunctionalBase::SmartPtr FunctionalPointer;
  FunctionalPointer functional( NULL );
  
  cmtk::UniformVolume::SmartPtr outputImage;
  if ( ImportBiasFieldAdd || ImportBiasFieldMul )
    {
    functional = cmtk::CreateEntropyMinimizationIntensityCorrectionFunctional( 1, 1 );

    if ( SamplingDensity > 0 )
      functional->SetSamplingDensity( SamplingDensity );

    if ( NumberOfHistogramBins )
      functional->SetNumberOfHistogramBins( NumberOfHistogramBins );

    functional->SetInputImage( inputImage );
    
    if ( ImportBiasFieldAdd )
      {
      cmtk::UniformVolume::SmartPtr biasAdd( cmtk::VolumeIO::ReadOriented( ImportBiasFieldAdd ) );
      if ( ! biasAdd || ! biasAdd->GetData() )
	{
	cmtk::StdErr << "ERROR: Could not read additive bias field image " << ImportBiasFieldAdd << "\n";
	throw cmtk::ExitException( 1 );
	}
      functional->SetBiasFieldAdd( *biasAdd );
      }

    if ( ImportBiasFieldMul )
      {
      cmtk::UniformVolume::SmartPtr biasMul( cmtk::VolumeIO::ReadOriented( ImportBiasFieldMul ) );
      if ( ! biasMul || ! biasMul->GetData() )
	{
	cmtk::StdErr << "ERROR: Could not read multiplicative bias field image " << ImportBiasFieldMul << "\n";
	throw cmtk::ExitException( 1 );
	}
      functional->SetBiasFieldMul( *biasMul );
      }

    outputImage = functional->GetOutputImage( true /*update*/ );
    }
  else
    {
    cmtk::CoordinateVector v;
    size_t polynomialDegreeFrom = std::max( PolynomialDegreeAdd, PolynomialDegreeMul );
    const size_t polynomialDegreeTo = polynomialDegreeFrom + 1;
    if ( IncrementalPolynomials )
      polynomialDegreeFrom = 1;
    
    for ( size_t polynomialDegree = polynomialDegreeFrom; polynomialDegree < polynomialDegreeTo; ++polynomialDegree )
      {
      const size_t degreeAdd = std::min<size_t>( polynomialDegree, PolynomialDegreeAdd );
      const size_t degreeMul = std::min<size_t>( polynomialDegree, PolynomialDegreeMul );

      functional = cmtk::CreateEntropyMinimizationIntensityCorrectionFunctional( degreeAdd, degreeMul, functional );
      functional->SetUseLogIntensities( LogIntensities );

      if ( SamplingDensity > 0 )
	functional->SetSamplingDensity( SamplingDensity );
      
      if ( NumberOfHistogramBins )
	functional->SetNumberOfHistogramBins( NumberOfHistogramBins );
      
      functional->SetInputImage( inputImage );
      if ( maskImage && maskImage->GetData() )
	{
	functional->SetForegroundMask( *maskImage );
	}
      else
	{
	cmtk::StdErr << "ERROR: please use a mask image. Seriously.\n";
	throw cmtk::ExitException( 1 );
	}
      functional->GetParamVector( v );
      
      cmtk::DebugOutput( 1 ).GetStream().printf( "Estimating bias field with order %u multiplicative / %u additive polynomials.\nNumber of parameters: %d\n", degreeMul, degreeAdd, v.Dim );

      if ( (PolynomialDegreeAdd > 0) || (PolynomialDegreeMul > 0) )
	{
	try
	  {
	  cmtk::Optimizer::SmartPtr optimizer;
	  optimizer = cmtk::Optimizer::SmartPtr( new cmtk::BestDirectionOptimizer );
	  optimizer->SetFunctional( functional );
	  
	  optimizer->Optimize( v, StepMax, StepMin );
	  }
	catch ( const char* cp )
	  {
	  cmtk::StdErr << "EXCEPTION: " << cp << "\n";
	  }
	v.Print();
	}
      }

    // make sure everything is according to optimum parameters
    outputImage = functional->GetOutputImage( v, false/*foregroundOnly*/ );
    }
  
  if ( FNameOutputImage )
    {
    if ( ! OutputFloatImage )
      {
      outputImage->GetData()->ReplacePaddingData( 0.0 );
      cmtk::TypedArray::SmartPtr convertedData( outputImage->GetData()->Convert( inputImage->GetData()->GetType() ) );
      outputImage->SetData( convertedData );
      }
    cmtk::VolumeIO::Write( *outputImage, FNameOutputImage );

#ifdef CMTK_USE_SQLITE
    if ( updateDB )
      {
      cmtk::ImageXformDB db( updateDB );
      db.AddImage( FNameOutputImage, FNameInputImage );
      }
#endif
    }

  if ( FNameBiasFieldAdd && PolynomialDegreeAdd )
    {
    cmtk::UniformVolume::SmartPtr biasField( functional->GetBiasFieldAdd( true /*completeImage*/ ) );
    cmtk::VolumeIO::Write( *biasField, FNameBiasFieldAdd );

#ifdef CMTK_USE_SQLITE
    if ( updateDB )
      {
      cmtk::ImageXformDB db( updateDB );
      db.AddImage( FNameBiasFieldAdd, FNameInputImage );
      }
#endif
    }

  if ( FNameBiasFieldMul && PolynomialDegreeMul )
    {
    cmtk::UniformVolume::SmartPtr biasField( functional->GetBiasFieldMul( true /*completeImage*/ ) );
    cmtk::VolumeIO::Write( *biasField, FNameBiasFieldMul );

#ifdef CMTK_USE_SQLITE
    if ( updateDB )
      {
      cmtk::ImageXformDB db( updateDB );
      db.AddImage( FNameBiasFieldMul, FNameInputImage );
      }
#endif
    }

  return 0;
}

#include "cmtkSafeMain"