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Partial Order Alignment for multiple sequence alignment
Some information about t-coffee from the Debian Med project.
POA is Partial Order Alignment, a fast program for multiple sequence
alignment (MSA) in bioinformatics. Its advantages are speed,
scalability, sensitivity, and the superior ability to handle branching
/ indels in the alignment. Partial order alignment is an approach to
MSA, which can be combined with existing methods such as progressive
alignment. POA optimally aligns a pair of MSAs and which therefore can
be applied directly to progressive alignment methods such as CLUSTAL.
For large alignments, Progressive POA is 10-30 times faster than
CLUSTALW. POA is published in Bioinformatics. 2004 Jul
10;20(10):1546-56.
See also: man poa
Homepage: http://www.bioinformatics.ucla.edu/poa
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