1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348
|
survplot.Design <-
function(fit, ..., xlim,
ylim=if(loglog)c(-5,1.5) else
if(what=="survival" & missing(fun))c(0,1),
xlab, ylab, time.inc,
what=c("survival","hazard"),
type=c("tsiatis","kaplan-meier"),
conf.type=c("log-log","log","plain","none"),
conf.int=FALSE, conf=c("bars","bands"), add=FALSE,
label.curves=TRUE, abbrev.label=FALSE,
lty,lwd=par('lwd'),col=1,
adj.subtitle,loglog=FALSE,fun,n.risk=FALSE,logt=FALSE,
dots=FALSE,dotsize=.003,grid=FALSE,
srt.n.risk=0,sep.n.risk=.056,adj.n.risk=1,
y.n.risk,cex.n.risk=.6, pr=FALSE) {
what <- match.arg(what)
if(.R.) ylim <- ylim ## before R changes missing(fun)
type <- match.arg(type)
conf.type <- match.arg(conf.type)
conf <- match.arg(conf)
psmfit <- inherits(fit,'psm') || (length(fit$fitFunction) &&
any(fit$fitFunction == 'psm'))
##14Nov00 22May01
if(what=="hazard" && !psmfit)
stop('what="hazard" may only be used for fits from psm')
if(what=="hazard" & conf.int>0) {
warning('conf.int may only be used with what="survival"')
conf.int <- FALSE
}
if(loglog) {fun <- function(x) logb(-logb(ifelse(x==0|x==1,NA,x))); use.fun <- TRUE}
else if(!missing(fun)) {
use.fun <- TRUE
if(loglog) stop("cannot specify loglog=T with fun")
}
else { fun <- function(x) x; use.fun <- FALSE }
if(what=="hazard" & loglog) stop('may not specify loglog=T with what="hazard"')
if(use.fun | logt | what=="hazard") { dots <- FALSE; grid <- FALSE }
cox <- inherits(fit,"cph") || (length(fit$fitFunction) &&
any(fit$fitFunction == 'cph'))
##14Nov00 22May01
if(cox) {
if(n.risk | conf.int>0) surv.sum <- fit$surv.summary
exactci <- !(is.null(fit$x)|is.null(fit$y))
ltype <- "s" #step functions for cph
}
else {
# if(n.risk | loglog)
# stop("the n.risk and loglog options only apply to fits from cph")
if(n.risk) stop("the n.risk option applies only to fits from cph")
exactci <- TRUE
ltype <- "l"
}
## if(n.risk && .R. && !missing(y.n.risk)) { ## 3nov02 24apr03
if(.R.) {
oxpd <- par('xpd')
par(xpd=NA)
on.exit(par(xpd=oxpd))
}
labelc <- is.list(label.curves) || label.curves
#atr <- attr(fit$terms, "Design") 17Apr01
atr <- fit$Design
if(!length(atr)) atr <- getOldDesign(fit)
Limval <- Getlim(atr, allow.null=TRUE, need.all=FALSE)
values <- Limval$values
assume <- atr$assume.code
if(is.null(assume))stop("fit does not have design information")
non.ia <- assume!=9 #limit list to main effects factors
f <- sum(non.ia)
name <- atr$name #interactions are placed at end by design
label <- atr$label
parms <- atr$parms
units <- fit$units
if(missing(ylab)) {
if(loglog) ylab <- "log(-log Survival Probability)"
else if(use.fun) ylab <- ""
else if(what=="hazard") ylab <- "Hazard Function"
else ylab <- "Survival Probability"
}
if(missing(xlab)) {
if(logt) xlab <- paste("log Survival Time in ",units,"s",sep="")
else xlab <- paste(units,"s",sep="")
}
maxtime <- fit$maxtime
maxtime <- max(pretty(c(0,maxtime)))
if(missing(time.inc)) time.inc <- fit$time.inc
if(missing(xlim))
xlim <- if(logt)logb(c(maxtime/100,maxtime)) else c(0,maxtime)
if(grid) {dots <- FALSE; if(is.logical(grid)) grid <- .05}
factors <- list(...)
nf <- length(factors)
if(nf<1)stop("must specify 1 factor to plot")
which <- charmatch(names(factors), name, 0)
if(any(which==0))stop(paste("factor(s) not in design:",
paste(names(factors)[which==0],collapse=" ")))
if(any(assume[which]==9 | assume[which]==10))
stop("may not plot interaction or matrix effects")
#Number of non-slopes
nrp <- num.intercepts(fit)
if(is.logical(conf.int)) {
if(conf.int) conf.int <- .95 else conf.int <- 0
}
zcrit <- qnorm((1+conf.int)/2)
xadj <- Limval$limits[2,assume!=9,drop=FALSE]
#for(i in 1:length(xadj)) if(is.factor(xadj[[i]]))
# xadj[[i]] <- as.character(xadj[[i]]) #preserves class data.frame
#commented out 14Feb95
#Use default adjusted to, replace some later
nv <- 1
y <- factors[[1]]
iy <- which[1]
iyt <- assume[iy]
y <- value.chk(atr, iy, y, 0, Limval)
nc <- length(y)
if(missing(adj.subtitle)) {
if(add)adj.subtitle <- FALSE else adj.subtitle <- f-nv <= 4
}
jf <- nv
if(nf>nv) for(i in which[(nv+1):nf]) {
jf <- jf+1
z <- factors[[jf]]
if(!is.na(z)) z <- value.chk(atr, i, z, 0, Limval)
if(is.na(z) | length(z)!=1)
stop("must specify single value for adjustment factors")
if(!is.na(z)) xadj[[name[i]]] <- z
}
#Put a legal value in for factor that's moving - will be ignored later.
#Just don't want it excluded from model frame
niy <- name[iy]
if(assume[iy]==5 | assume[iy]==8) xadj[[niy]] <- parms[[niy]][1] else
if(assume[iy]<8 && !is.null(V <- values[[niy]]) && is.character(V))
xadj[[niy]] <- V[1] else
xadj[[niy]] <- 1
isna <- sapply(xadj, is.na)
if(any(isna)) stop(
paste("settings not defined here or with datadist for",
paste(name[isna],collapse=" ")))
beta <- fit$coef
#if(conf.int>0) cov <- fit$var
curve.labels <- NULL
xd <- xlim[2]-xlim[1]
if(n.risk & !add) {
mar <- par()$mar
if(mar[4]<4){mar[4] <- mar[4]+2; par(mar=mar)}
}
# One curve for each value of y, excl style used for C.L.
if(missing(lty)) lty <- seq(nc+1)[-2] else
lty <- rep(lty, length=nc)
col <- rep(col, length=nc)
lwd <- rep(lwd, length=nc)
i <- 0
abbrevy <- if(abbrev.label) abbreviate(y) else y
abbrevy <- if(is.factor(abbrevy)) as.character(abbrevy) else format(abbrevy)
if(labelc) curves <- vector('list',nc)
for(ay in y) {
i <- i+1
adj <- xadj
adj[[name[iy]]] <- ay
adj <- data.frame(adj)
index.y <- i
ci <- conf.int
w <- survest(fit,newdata=adj,fun=fun,what=what,
conf.int=ci,type=type,conf.type=conf.type)
time <- w$time
if(logt) time <- logb(time)
s <- !is.na(time) & (time>=xlim[1]) #& (time<=xlim[2])
surv <- w$surv
if(is.null(ylim)) ylim <- range(surv, na.rm=TRUE)
stratum <- w$strata
if(is.null(stratum)) stratum <- 1
if(!is.na(stratum)) {
#can be NA if illegal strata combinations requested
if(is.factor(ay)) cl <- as.character(ay)
else cl <- format(ay)
curve.labels <- c(curve.labels, abbrevy[i])
if(i==1 & !add) {
plot(time,surv,xlab=xlab,xlim=xlim,
ylab=ylab,ylim=ylim,type="n",axes=FALSE)
mgp.axis(1,at=if(logt)pretty(xlim) else
seq(xlim[1],max(pretty(xlim)),time.inc),labels=TRUE) #2Jun99
mgp.axis(2, at=pretty(ylim)) #7Feb98, 2Jun99
if(!logt & (dots|grid)) {
xlm <- pretty(xlim)
xlm <- c(xlm[1],xlm[length(xlm)])
xp <- seq(xlm[1],xlm[2],by=time.inc)
yd <- ylim[2]-ylim[1]
if(yd<=.1)yi <- .01
else if(yd<=.2) yi <- .025
else if(yd<=.4) yi <- .05
else yi <- .1
yp <- seq(ylim[2],ylim[1]+if(n.risk && missing(y.n.risk))yi else 0,
by=-yi)
if(dots) for(tt in xp)symbols(rep(tt,length(yp)),yp,
circle=rep(dotsize,length(yp)),
inches=dotsize,add=TRUE)
else abline(h=yp, v=xp, col=grid)
}
}
tim <- time[s]; srv <- surv[s]
if(conf.int>0 && conf=='bands') { ## 5Apr02
blower <- w$lower[s]
bupper <- w$upper[s]
}
if(max(tim)>xlim[2]) {
if(ltype=="s") {
##Get estimate at last permissible point to plot
## s.last <- min(srv[tim<=xlim[2]+1e-6]) #not work with function
s.last <- srv[tim <= xlim[2] + 1e-6]
s.last <- s.last[length(s.last)]
k <- tim < xlim[2]
tim <- c(tim[k], xlim[2]); srv <- c(srv[k], s.last)
if(conf.int>0 && conf=='bands') { ## 5Apr02
low.last <- blower[time <= xlim[2] + 1e-6]
low.last <- low.last[length(low.last)]
up.last <- bupper[time <= xlim[2] + 1e-6]
up.last <- up.last[length(up.last)]
blower <- c(blower[k],low.last)
bupper <- c(bupper[k],up.last)
}
}
else tim[tim>xlim[2]] <- NA
}
##don't let step function go beyond x-axis -
##this cuts it off but allows step to proceed axis end
lines(tim,srv,type=ltype,lty=lty[i],col=col[i],lwd=lwd[i])
if(labelc) curves[[i]] <- list(tim, srv)
if(pr) {
zest <- rbind(tim,srv)
dimnames(zest) <- list(c("Time","Survival"), rep("",length(srv)))
cat("\nEstimates for ", cl,"\n\n")
print(zest, digits=3)
}
if(conf.int>0) {
if(conf=="bands") {
lines(tim,blower,type=ltype,lty=2,col=col[i],lwd=1)
lines(tim,bupper,type=ltype,lty=2,col=col[i],lwd=1)
## was w$lower[s], w$upper[s] 5Apr02
} else {
if(exactci) { # not from cph(surv=T)
tt <- seq(0, maxtime, time.inc)
v <- survest(fit, newdata=adj,times=tt, what=what, fun=fun,
conf.int=ci, type=type,conf.type=conf.type)
tt <- v$time #may not get predictions at all t
ss <- v$surv; lower <- v$lower; upper <- v$upper
if(is.null(ylim)) ylim <- range(ss, na.rm=TRUE)
if(logt) tt <- logb(ifelse(tt==0,NA,tt))
}
else {
tt <- as.single(dimnames(surv.sum)[[1]])
if(logt) tt <- logb(tt)
ss <- surv.sum[,stratum,1]^exp(w$linear.predictors)
se <- surv.sum[,stratum,3]
ss <- fun(ss)
lower <- fun(ss^exp(zcrit*se))
upper <- fun(ss^exp(-zcrit*se))
ss[is.infinite(ss)] <- NA; lower[is.infinite(lower)] <- NA
upper[is.infinite(upper)] <- NA
}
tt <- tt + xd*(i-1)*.01
errbar(tt, ss, upper, lower, add=TRUE, lty=lty[i], col=col[i])
}
}
if(n.risk) {
if(!is.null(Y <- fit$y)) {
tt <- seq(max(0,xlim[1]),min(maxtime,xlim[2]),by=time.inc)
ny <- ncol(Y)
if(is.null(str <- attr(Y,"strata"))) Y <- Y[,ny-1]
else Y <- Y[oldUnclass(str)==oldUnclass(stratum),ny-1]
nrisk <- rev(cumsum(table(
if(version$major < 5)
cut(-Y,sort(unique(-c(tt,range(Y)+c(-1,1)))))
else oldCut(-Y,sort(unique(-c(tt,range(Y)+c(-1,1)))))
)[-length(tt)-1]))
}
else {
if(is.null(surv.sum))
stop("you must use surv=T or y=T in fit to use n.risk=T")
tt <- as.single(dimnames(surv.sum)[[1]])
l <- (tt >= xlim[1]) & (tt <= xlim[2])
tt <- tt[l]; nrisk <- surv.sum[l,stratum,2]
}
tt[1] <- xlim[1] #was xd*.015, .030, .035
yd <- ylim[2]-ylim[1]
if(missing(y.n.risk)) y.n.risk <- ylim[1]
yy <- y.n.risk+yd*(nc-i)*sep.n.risk #was .029, .038, .049
# Generalized 11Oct96 to y.n.risk from ylim[1]
nri <- nrisk; nri[tt>xlim[2]] <- NA # added 2Sep94
text(tt[1],yy,nri[1],cex=cex.n.risk,
adj=adj.n.risk,srt=srt.n.risk)
text(tt[-1],yy,nri[-1],cex=cex.n.risk,adj=1)
text(xlim[2]+xd*.025,yy,adj=0,curve.labels[i],cex=cex.n.risk)
}
}
}
if(labelc) labcurve(curves, curve.labels, type=ltype, lty=lty, col=col,
lwd=lwd, opts=label.curves)
adjust <- ""
if(f>nv) for(i in 1:f) {
if(!any(i==which[1:nv])) {
if(is.numeric(xadj[,i])) fv <- format(xadj[,i])
#format won't work with factors
else fv <- as.character(xadj[,i])
adjust <- paste(adjust, name[i], "=", fv, " ",sep="")}
}
if(adjust!="" & adj.subtitle) title(sub=paste("Adjusted to:",adjust),
adj=0,cex=.6)
invisible(list(adjust=adjust, curve.labels=curve.labels))
}
|