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#ifndef _MCIO_
#define _MCIO_
#include <stdio.h>
#include <string.h>
#include <ctype.h>
#include <unistd.h>
#include <math.h>
#include <vsubs.h>
#include <admutils.h>
#define MAXSTR 512
#define LONGSTR 10000
#define MAXFF 50
#define MAXCH 100
#define MTCHROM 90
#define XYCHROM 91
#define BADCHROM 99
#define GDISMUL 1000000
// multiplier for gdis to make integer for sort
enum outputmodetype
{
ANCESTRYMAP, EIGENSTRAT, PED, PACKEDPED, PACKEDANCESTRYMAP
};
typedef struct
{
char ID[IDSIZE];
double gpos;
double ppos;
int chrom;
char cchrom[6];
int nn[4];
int ignore;
int isrfake;
char alleles[2];
int inputrow;
int cuptnum;
int chimpfudge;
} SNPDATA;
int
numfakes (SNPDATA **snpraw, int *snpindx, int nreal, double spacing);
double
nextmesh (double val, double spacing);
double
interp (double l, double r, double x, double al, double ar);
int
loadsnps (SNP **snpm, SNPDATA **snpraw, int *snpindx, int nreal, double spacing,
int *numignore);
int
readsnpdata (SNPDATA **snpraw, char *fname);
int
readinddata (Indiv **indivmarkers, char *fname);
int
readindpeddata (Indiv **indivmarkers, char *fname);
void
pedname (char *name, char *sx0, char *sx1);
int
readtldata (Indiv **indivmarkers, int numind, char *fname);
int
readindval (Indiv **indivmarkers, int numind, char *fname);
int
readfreqdata (SNP **snpm, int numsnps, char *fname);
void
clearsnp (SNP *cupt);
int
rmindivs (SNP **snpm, int numsnps, Indiv **indivmarkers, int numindivs);
int
rmsnps (SNP **snpm, int numsnps, char *deletesnpoutname);
void
clearind (Indiv **indm, int numind);
void
cleartg (Indiv **indm, int nind);
double
mknn (int *nn, int n0, int n1);
void
clearsnpord ();
int
getsnps (char *snpfname, SNP ***snpmarkpt, double spacing, char *badsnpname,
int *nignore, int numrisks);
int
getsizex (char *fname);
int
getindivs (char *indivfname, Indiv ***indmarkpt);
int
setstatus (Indiv **indm, int numindivs, char *smatch);
int
setstatusv (Indiv **indm, int numindivs, char *smatch, int val);
long
getgenos (char *genoname, SNP **snpmarkers, Indiv **indivmarkers, int numsnps,
int numindivs, int nignore);
void
getgenos_list (char *genotypelist, SNP **snpmarkers, Indiv **indivmarkers,
int numsnps, int numindivs, int nignore);
void
printsnps (char *snpoutfilename, SNP **snpm, int num, Indiv **indm,
int printfake, int printvalids);
int
checkxval (SNP *cupt, Indiv *indx, int val);
void
printdata (char *genooutfilename, char *indoutfilename, SNP **snpm,
Indiv **indiv, int numsnps, int numind, int packmode);
int
readgdata (Indiv **indivmarkers, int numind, char *gname);
int
numvalidind (Indiv **indivmarkers, int numind);
int
numvalidgtind (SNP **snpm, int numsnps, int ind);
int
numvalidgt (Indiv **indivmarkers, SNP *cupt);
int
numvalidgtx (Indiv **indivmarkers, SNP *cupt, int affst);
int
getweights (char *fname, SNP **snpm, int numsnps);
void
outpack (char *genooutfilename, SNP **snpm, Indiv **indiv, int numsnps,
int numind);
int
ispack (char *gname);
int
iseigenstrat (char *gname);
void
inpack (char *genooutfilename, SNP **snpm, Indiv **indiv, int numsnps,
int numind);
int
inpack2 (char *genooutfilename, SNP **snpm, Indiv **indiv, int numsnps,
int numind);
int
ineigenstrat (char *genooutfilename, SNP **snpm, Indiv **indiv, int numsnps,
int numind);
void
setepath (SNP **snpm, int n);
void
clearepath (char *xpack);
long
bigread (int fdes, char *packg, long numbytes);
// pedfile support
int
getpedgenos (char *genoname, SNP **snpmarkers, Indiv **indivmarkers,
int numsnps, int numindivs, int nignore);
void
genopedcnt (char *genoname, int **gcounts, int nsnp);
int
pedval (char *sx);
int
xpedval (char c);
int
ptoachrom (char *ss);
void
setgref (int **gcounts, int nsnp, int *gvar, int *gref);
void
cleargdata (SNP **snpmarkers, int numsnps, int numindivs);
void
setgenotypename (char **gname, char *iname);
void
settersemode (int mode);
void
dobadsnps (SNPDATA **snpraw, int nreal, char *badsnpname);
int
snprawindex (SNPDATA **snpraw, int nreal, char *sname);
int
readsnpmapdata (SNPDATA **snpraw, char *fname);
int
checkfake (char *ss);
void
setbadpedignore ();
int
setsdpos (SNPDATA *sdpt, int pos);
void
outeigenstrat (char *snpname, char *indname, char *gname, SNP **snpm,
Indiv **indiv, int numsnps, int numind);
void
outped (char *snpname, char *indname, char *gname, SNP **snpm, Indiv **indiv,
int numsnps, int numind, int ogmode);
void
outpackped (char *snpname, char *indname, char *gname, SNP **snpm,
Indiv **indiv, int numsnps, int numind, int ogmode);
void
setbedbuff (char *buff, int *gtypes, int numind);
int
bedval (int g);
int
str2chrom (char *ss);
void
outindped (char *indname, Indiv **indiv, int numind, int ogmode);
void
printmap (char *snpname, SNP **snpm, int numsnps, Indiv **indiv);
int
maxlinelength (char *fname);
int
checksize (int numindivs, int numsnps, enum outputmodetype outputmode);
void
setomode (enum outputmodetype *outmode, char *omode);
void
outfiles (char *snpname, char *indname, char *gname, SNP **snpm, Indiv **indiv,
int numsnps, int numind, int packem, int ogmode);
void
snpdecimate (SNP **snpm, int nsnp, int decim, int mindis, int maxdis);
void
decimate (SNP **cbuff, int n, int decim, int mindis, int maxdis);
int
vvadjust (double *cc, int n, double *pmean);
int
killhir2 (SNP **snpm, int numsnps, int numind, double physlim, double genlim,
double rhothresh);
void
freecupt (SNP **cupt);
void
freeped ();
void
cntpops (int *count, Indiv **indm, int numindivs, char **eglist, int numeg);
void
printalleles (SNP *cupt, FILE *fff);
char *
getpackgenos ();
void
clearpackgenos ();
void
setchr (int mode);
void
setchimpmode (int mode);
int
genoopenit (genofile **gfile, char *geno2name, SNP **snp2m, Indiv **indiv2m,
int numsnp2, int numindiv2, int nignore);
int
genoreadit (genofile *gfile, SNP **pcupt);
void
genocloseit (genofile *gfile);
void
putped (int num);
void
getped (int num);
void
logdeletedsnp (char *snpname, char *cmnt, char *deletesnpoutname);
void
sortsnps (SNP **snpa, SNP **snpb, int n);
void
setpordercheck (int mode);
void
putsnpordered (int mode);
int
getsnpordered ();
#endif
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