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/*=========================================================================
*
* Copyright UMC Utrecht and contributors
*
* Licensed under the Apache License, Version 2.0 (the "License");
* you may not use this file except in compliance with the License.
* You may obtain a copy of the License at
*
* http://www.apache.org/licenses/LICENSE-2.0.txt
*
* Unless required by applicable law or agreed to in writing, software
* distributed under the License is distributed on an "AS IS" BASIS,
* WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
* See the License for the specific language governing permissions and
* limitations under the License.
*
*=========================================================================*/
#ifndef elxAdvancedBSplineTransform_hxx
#define elxAdvancedBSplineTransform_hxx
#include "elxAdvancedBSplineTransform.h"
#include "itkImageRegionExclusionConstIteratorWithIndex.h"
#include <vnl/vnl_math.h>
namespace elastix
{
/**
* ************ InitializeBSplineTransform ***************
*/
template <class TElastix>
unsigned int
AdvancedBSplineTransform<TElastix>::InitializeBSplineTransform()
{
/** Initialize the right BSplineTransform and GridScheduleComputer. */
if (this->m_Cyclic)
{
this->m_GridScheduleComputer = CyclicGridScheduleComputerType::New();
this->m_GridScheduleComputer->SetBSplineOrder(this->m_SplineOrder);
m_BSplineTransform =
BSplineTransformBaseType::template Create<itk::CyclicBSplineDeformableTransform>(m_SplineOrder);
}
else
{
this->m_GridScheduleComputer = GridScheduleComputerType::New();
this->m_GridScheduleComputer->SetBSplineOrder(this->m_SplineOrder);
m_BSplineTransform =
BSplineTransformBaseType::template Create<itk::AdvancedBSplineDeformableTransform>(m_SplineOrder);
}
this->SetCurrentTransform(this->m_BSplineTransform);
this->m_GridUpsampler = GridUpsamplerType::New();
this->m_GridUpsampler->SetBSplineOrder(this->m_SplineOrder);
return 0;
} // end InitializeBSplineTransform()
/**
* ******************* BeforeAll ***********************
*/
template <class TElastix>
int
AdvancedBSplineTransform<TElastix>::BeforeAll()
{
/** Read spline order and periodicity setting from configuration file. */
this->m_SplineOrder = 3;
this->GetConfiguration()->ReadParameter(
this->m_SplineOrder, "BSplineTransformSplineOrder", this->GetComponentLabel(), 0, 0, true);
this->m_Cyclic = false;
this->GetConfiguration()->ReadParameter(this->m_Cyclic, "UseCyclicTransform", this->GetComponentLabel(), 0, 0, true);
return this->InitializeBSplineTransform();
} // end BeforeAll()
/**
* ******************* BeforeRegistration ***********************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::BeforeRegistration()
{
/** Set initial transform parameters to a 1x1x1 grid, with deformation (0,0,0).
* In the method BeforeEachResolution() this will be replaced by the right grid size.
* This seems not logical, but it is required, since the registration
* class checks if the number of parameters in the transform is equal to
* the number of parameters in the registration class. This check is done
* before calling the BeforeEachResolution() methods.
*/
/** Task 1 - Set the Grid. */
/** Set gridsize for large dimension to 4 to prevent errors when checking
* on support region size.
*/
SizeType gridsize = SizeType::Filled(1);
gridsize.SetElement(gridsize.GetSizeDimension() - 1, 4);
/** Set it all. */
this->m_BSplineTransform->SetGridRegion(RegionType(gridsize));
this->m_BSplineTransform->SetGridSpacing(SpacingType(1.0));
this->m_BSplineTransform->SetGridOrigin(OriginType());
/** Task 2 - Give the registration an initial parameter-array. */
this->m_Registration->GetAsITKBaseType()->SetInitialTransformParameters(
ParametersType(this->GetNumberOfParameters(), 0.0));
/** Precompute the B-spline grid regions. */
this->PreComputeGridInformation();
} // end BeforeRegistration()
/**
* ***************** BeforeEachResolution ***********************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::BeforeEachResolution()
{
/** What is the current resolution level? */
unsigned int level = this->m_Registration->GetAsITKBaseType()->GetCurrentLevel();
/** Define the grid. */
if (level == 0)
{
this->InitializeTransform();
}
else
{
/** Upsample the B-spline grid, if required. */
this->IncreaseScale();
}
/** Get the PassiveEdgeWidth and use it to set the OptimizerScales. */
unsigned int passiveEdgeWidth = 0;
this->GetConfiguration()->ReadParameter(
passiveEdgeWidth, "PassiveEdgeWidth", this->GetComponentLabel(), level, 0, false);
this->SetOptimizerScales(passiveEdgeWidth);
} // end BeforeEachResolution()
/**
* ******************** PreComputeGridInformation ***********************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::PreComputeGridInformation()
{
/** Get the total number of resolution levels. */
unsigned int nrOfResolutions = this->m_Registration->GetAsITKBaseType()->GetNumberOfLevels();
/** Set up grid schedule computer with image info. */
this->m_GridScheduleComputer->SetImageOrigin(this->GetElastix()->GetFixedImage()->GetOrigin());
this->m_GridScheduleComputer->SetImageSpacing(this->GetElastix()->GetFixedImage()->GetSpacing());
this->m_GridScheduleComputer->SetImageDirection(this->GetElastix()->GetFixedImage()->GetDirection());
this->m_GridScheduleComputer->SetImageRegion(this->GetElastix()->GetFixedImage()->GetLargestPossibleRegion());
/** Take the initial transform only into account, if composition is used. */
if (this->GetUseComposition())
{
this->m_GridScheduleComputer->SetInitialTransform(this->Superclass1::GetInitialTransform());
}
/** Get the grid spacing schedule from the parameter file.
*
* Method 1: The user specifies "FinalGridSpacingInVoxels"
* Method 2: The user specifies "FinalGridSpacingInPhysicalUnits"
*
* Method 1 and 2 additionally take the "GridSpacingSchedule".
* The GridSpacingSchedule is defined by downsampling factors
* for each resolution, for each dimension (just like the image
* pyramid schedules). So, for 2D images, and 3 resulutions,
* we can specify:
* (GridSpacingSchedule 4.0 4.0 2.0 2.0 1.0 1.0)
* Which is the default schedule, if no GridSpacingSchedule is supplied.
*/
/** Determine which method is used. */
bool method1 = false;
std::size_t count1 = this->m_Configuration->CountNumberOfParameterEntries("FinalGridSpacingInVoxels");
if (count1 > 0)
{
method1 = true;
}
bool method2 = false;
std::size_t count2 = this->m_Configuration->CountNumberOfParameterEntries("FinalGridSpacingInPhysicalUnits");
if (count2 > 0)
{
method2 = true;
}
/** Throw an exception if both methods are used. */
if (count1 > 0 && count2 > 0)
{
itkExceptionMacro("ERROR: You can not specify both \"FinalGridSpacingInVoxels\""
" and \"FinalGridSpacingInPhysicalUnits\" in the parameter file.");
}
/** Declare variables and set defaults. */
SpacingType finalGridSpacingInVoxels;
SpacingType finalGridSpacingInPhysicalUnits;
finalGridSpacingInVoxels.Fill(16.0);
finalGridSpacingInPhysicalUnits.Fill(8.0);
/** Method 1: Read the FinalGridSpacingInVoxels. */
if (method1)
{
for (unsigned int dim = 0; dim < SpaceDimension; ++dim)
{
this->m_Configuration->ReadParameter(
finalGridSpacingInVoxels[dim], "FinalGridSpacingInVoxels", this->GetComponentLabel(), dim, 0);
}
/** Compute the grid spacing in physical units. */
for (unsigned int dim = 0; dim < SpaceDimension; ++dim)
{
finalGridSpacingInPhysicalUnits[dim] =
finalGridSpacingInVoxels[dim] * this->GetElastix()->GetFixedImage()->GetSpacing()[dim];
}
}
/** Method 2: Read the FinalGridSpacingInPhysicalUnits. */
if (method2)
{
for (unsigned int dim = 0; dim < SpaceDimension; ++dim)
{
this->m_Configuration->ReadParameter(
finalGridSpacingInPhysicalUnits[dim], "FinalGridSpacingInPhysicalUnits", this->GetComponentLabel(), dim, 0);
}
}
/** Set up a default grid spacing schedule. */
this->m_GridScheduleComputer->SetDefaultSchedule(nrOfResolutions, 2.0);
GridScheduleType gridSchedule;
this->m_GridScheduleComputer->GetSchedule(gridSchedule);
/** Read what the user has specified. This overrules everything. */
count2 = this->m_Configuration->CountNumberOfParameterEntries("GridSpacingSchedule");
unsigned int entry_nr = 0;
if (count2 == 0)
{
// keep the default schedule
}
else if (count2 == nrOfResolutions)
{
for (unsigned int res = 0; res < nrOfResolutions; ++res)
{
for (unsigned int dim = 0; dim < SpaceDimension; ++dim)
{
this->m_Configuration->ReadParameter(gridSchedule[res][dim], "GridSpacingSchedule", entry_nr, false);
}
++entry_nr;
}
}
else if (count2 == nrOfResolutions * SpaceDimension)
{
for (unsigned int res = 0; res < nrOfResolutions; ++res)
{
for (unsigned int dim = 0; dim < SpaceDimension; ++dim)
{
this->m_Configuration->ReadParameter(gridSchedule[res][dim], "GridSpacingSchedule", entry_nr, false);
++entry_nr;
}
}
}
else
{
log::error(std::ostringstream{}
<< "ERROR: Invalid GridSpacingSchedule! The number of entries behind the GridSpacingSchedule "
"option should equal the numberOfResolutions, or the numberOfResolutions * ImageDimension.");
itkExceptionMacro("ERROR: Invalid GridSpacingSchedule!");
}
/** Output a warning that the gridspacing may be adapted to fit the Cyclic
* behavior of the transform.
*/
if (this->m_Cyclic)
{
log::warn(
"WARNING: The provided grid spacing may be adapted to fit the cyclic behavior of the CyclicBSplineTransform.");
}
/** Set the grid schedule and final grid spacing in the schedule computer. */
this->m_GridScheduleComputer->SetFinalGridSpacing(finalGridSpacingInPhysicalUnits);
this->m_GridScheduleComputer->SetSchedule(gridSchedule);
/** Compute the necessary information. */
this->m_GridScheduleComputer->ComputeBSplineGrid();
} // end PreComputeGridInformation()
/**
* ******************** InitializeTransform ***********************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::InitializeTransform()
{
/** Compute the B-spline grid region, origin, and spacing. */
RegionType gridRegion;
OriginType gridOrigin;
SpacingType gridSpacing;
DirectionType gridDirection;
this->m_GridScheduleComputer->GetBSplineGrid(0, gridRegion, gridSpacing, gridOrigin, gridDirection);
/** Set it in the BSplineTransform. */
this->m_BSplineTransform->SetGridRegion(gridRegion);
this->m_BSplineTransform->SetGridSpacing(gridSpacing);
this->m_BSplineTransform->SetGridOrigin(gridOrigin);
this->m_BSplineTransform->SetGridDirection(gridDirection);
/** Set initial parameters for the first resolution to 0.0. */
ParametersType initialParameters(this->GetNumberOfParameters(), 0.0);
this->m_Registration->GetAsITKBaseType()->SetInitialTransformParametersOfNextLevel(initialParameters);
} // end InitializeTransform()
/**
* *********************** IncreaseScale ************************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::IncreaseScale()
{
/** What is the current resolution level? */
unsigned int level = this->m_Registration->GetAsITKBaseType()->GetCurrentLevel();
/** The current grid. */
OriginType currentGridOrigin = this->m_BSplineTransform->GetGridOrigin();
SpacingType currentGridSpacing = this->m_BSplineTransform->GetGridSpacing();
RegionType currentGridRegion = this->m_BSplineTransform->GetGridRegion();
DirectionType currentGridDirection = this->m_BSplineTransform->GetGridDirection();
/** The new required grid. */
OriginType requiredGridOrigin{};
SpacingType requiredGridSpacing;
requiredGridSpacing.Fill(1.0);
RegionType requiredGridRegion;
DirectionType requiredGridDirection;
this->m_GridScheduleComputer->GetBSplineGrid(
level, requiredGridRegion, requiredGridSpacing, requiredGridOrigin, requiredGridDirection);
/** Get the latest transform parameters. */
ParametersType latestParameters = this->m_Registration->GetAsITKBaseType()->GetLastTransformParameters();
/** Setup the GridUpsampler. */
this->m_GridUpsampler->SetCurrentGridOrigin(currentGridOrigin);
this->m_GridUpsampler->SetCurrentGridSpacing(currentGridSpacing);
this->m_GridUpsampler->SetCurrentGridRegion(currentGridRegion);
this->m_GridUpsampler->SetCurrentGridDirection(currentGridDirection);
this->m_GridUpsampler->SetRequiredGridOrigin(requiredGridOrigin);
this->m_GridUpsampler->SetRequiredGridSpacing(requiredGridSpacing);
this->m_GridUpsampler->SetRequiredGridRegion(requiredGridRegion);
this->m_GridUpsampler->SetRequiredGridDirection(requiredGridDirection);
/** Compute the upsampled B-spline parameters. */
ParametersType upsampledParameters;
this->m_GridUpsampler->UpsampleParameters(latestParameters, upsampledParameters);
/** Set the new grid definition in the BSplineTransform. */
this->m_BSplineTransform->SetGridOrigin(requiredGridOrigin);
this->m_BSplineTransform->SetGridSpacing(requiredGridSpacing);
this->m_BSplineTransform->SetGridRegion(requiredGridRegion);
this->m_BSplineTransform->SetGridDirection(requiredGridDirection);
/** Set the initial parameters for the next level. */
this->m_Registration->GetAsITKBaseType()->SetInitialTransformParametersOfNextLevel(upsampledParameters);
/** Set the parameters in the BsplineTransform. */
this->m_BSplineTransform->SetParameters(
this->m_Registration->GetAsITKBaseType()->GetInitialTransformParametersOfNextLevel());
} // end IncreaseScale()
/**
* ************************* ReadFromFile ************************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::ReadFromFile()
{
/** Read spline order and periodicity settings and initialize BSplineTransform. */
this->m_SplineOrder = 3;
this->GetConfiguration()->ReadParameter(
this->m_SplineOrder, "BSplineTransformSplineOrder", this->GetComponentLabel(), 0, 0);
this->m_Cyclic = false;
this->GetConfiguration()->ReadParameter(this->m_Cyclic, "UseCyclicTransform", this->GetComponentLabel(), 0, 0);
this->InitializeBSplineTransform();
/** Read and Set the Grid: this is a BSplineTransform specific task. */
/** Declarations. Everything filled with default values.*/
SizeType gridsize = SizeType::Filled(1);
IndexType gridindex = { { 0 } };
SpacingType gridspacing(1.0);
OriginType gridorigin{};
DirectionType griddirection = DirectionType::GetIdentity();
/** Get GridSize, GridIndex, GridSpacing and GridOrigin. */
for (unsigned int i = 0; i < SpaceDimension; ++i)
{
this->m_Configuration->ReadParameter(gridsize[i], "GridSize", i);
this->m_Configuration->ReadParameter(gridindex[i], "GridIndex", i);
this->m_Configuration->ReadParameter(gridspacing[i], "GridSpacing", i);
this->m_Configuration->ReadParameter(gridorigin[i], "GridOrigin", i);
for (unsigned int j = 0; j < SpaceDimension; ++j)
{
this->m_Configuration->ReadParameter(griddirection(j, i), "GridDirection", i * SpaceDimension + j);
}
}
/** Set it all. */
this->m_BSplineTransform->SetGridRegion(RegionType(gridindex, gridsize));
this->m_BSplineTransform->SetGridSpacing(gridspacing);
this->m_BSplineTransform->SetGridOrigin(gridorigin);
this->m_BSplineTransform->SetGridDirection(griddirection);
/** Call the ReadFromFile from the TransformBase.
* This must be done after setting the Grid, because later the
* ReadFromFile from TransformBase calls SetParameters, which
* checks the parameter-size, which is based on the GridSize.
*/
this->Superclass2::ReadFromFile();
} // end ReadFromFile()
/**
* ************************* CreateDerivedTransformParameterMap ************************
*/
template <class TElastix>
auto
AdvancedBSplineTransform<TElastix>::CreateDerivedTransformParameterMap() const -> ParameterMapType
{
const auto gridRegion = m_BSplineTransform->GetGridRegion();
return { { "GridSize", Conversion::ToVectorOfStrings(gridRegion.GetSize()) },
{ "GridIndex", Conversion::ToVectorOfStrings(gridRegion.GetIndex()) },
{ "GridSpacing", Conversion::ToVectorOfStrings(m_BSplineTransform->GetGridSpacing()) },
{ "GridOrigin", Conversion::ToVectorOfStrings(m_BSplineTransform->GetGridOrigin()) },
{ "GridDirection", Conversion::ToVectorOfStrings(m_BSplineTransform->GetGridDirection()) },
{ "BSplineTransformSplineOrder", { Conversion::ToString(m_SplineOrder) } },
{ "UseCyclicTransform", { Conversion::ToString(m_Cyclic) } } };
} // end CreateDerivedTransformParameterMap()
/**
* *********************** SetOptimizerScales ***********************
*/
template <class TElastix>
void
AdvancedBSplineTransform<TElastix>::SetOptimizerScales(const unsigned int edgeWidth)
{
/** Some typedefs. */
using ScalesValueType = itk::Optimizer::ScalesType::ValueType;
/** Define new scales. */
const NumberOfParametersType numberOfParameters = this->m_BSplineTransform->GetNumberOfParameters();
const unsigned long offset = numberOfParameters / SpaceDimension;
itk::Optimizer::ScalesType newScales(numberOfParameters, ScalesValueType{ 1.0 });
const ScalesValueType infScale = 10000.0;
if (edgeWidth == 0)
{
/** Just set the unit scales into the optimizer. */
this->m_Registration->GetAsITKBaseType()->GetModifiableOptimizer()->SetScales(newScales);
return;
}
/** Get the grid region information and create a fake coefficient image. */
RegionType gridregion = this->m_BSplineTransform->GetGridRegion();
SizeType gridsize = gridregion.GetSize();
IndexType gridindex = gridregion.GetIndex();
ImagePointer coeff = ImageType::New();
coeff->SetRegions(gridregion);
coeff->Allocate();
/** Determine inset region. (so, the region with active parameters). */
RegionType insetgridregion;
SizeType insetgridsize;
IndexType insetgridindex;
for (unsigned int i = 0; i < SpaceDimension; ++i)
{
insetgridsize[i] = static_cast<unsigned int>(std::max(0, static_cast<int>(gridsize[i] - 2 * edgeWidth)));
if (insetgridsize[i] == 0)
{
log::error(std::ostringstream{} << "ERROR: you specified a PassiveEdgeWidth of " << edgeWidth
<< ", while the total grid size in dimension " << i << " is only " << gridsize[i]
<< ".");
itkExceptionMacro("ERROR: the PassiveEdgeWidth is too large!");
}
insetgridindex[i] = gridindex[i] + edgeWidth;
}
insetgridregion.SetSize(insetgridsize);
insetgridregion.SetIndex(insetgridindex);
/** Set up iterator over the coefficient image. */
itk::ImageRegionExclusionConstIteratorWithIndex<ImageType> cIt(coeff, coeff->GetLargestPossibleRegion());
cIt.SetExclusionRegion(insetgridregion);
cIt.GoToBegin();
/** Set the scales to infinity that correspond to edge coefficients
* This (hopefully) makes sure they are not optimized during registration.
*/
while (!cIt.IsAtEnd())
{
const IndexType & index = cIt.GetIndex();
const unsigned long baseOffset = coeff->ComputeOffset(index);
for (unsigned int i = 0; i < SpaceDimension; ++i)
{
const unsigned int scalesIndex = static_cast<unsigned int>(baseOffset + i * offset);
newScales[scalesIndex] = infScale;
}
++cIt;
}
/** Set the scales into the optimizer. */
this->m_Registration->GetAsITKBaseType()->GetModifiableOptimizer()->SetScales(newScales);
} // end SetOptimizerScales()
} // end namespace elastix
#endif // end #ifndef elxAdvancedBSplineTransform_hxx
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