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/*=========================================================================
*
* Copyright UMC Utrecht and contributors
*
* Licensed under the Apache License, Version 2.0 (the "License");
* you may not use this file except in compliance with the License.
* You may obtain a copy of the License at
*
* http://www.apache.org/licenses/LICENSE-2.0.txt
*
* Unless required by applicable law or agreed to in writing, software
* distributed under the License is distributed on an "AS IS" BASIS,
* WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
* See the License for the specific language governing permissions and
* limitations under the License.
*
*=========================================================================*/
#ifndef elxBSplineTransformWithDiffusion_h
#define elxBSplineTransformWithDiffusion_h
/* For easy changing the BSplineOrder: */
#define __VSplineOrder 3
#include "elxIncludes.h" // include first to avoid MSVS warning
#include "itkAdvancedBSplineDeformableTransform.h"
#include "itkAdvancedCombinationTransform.h"
//#include "itkBSplineCombinationTransform.h"
#include "itkBSplineResampleImageFilterBase.h"
#include "itkBSplineUpsampleImageFilter.h"
#include "itkImageRegionConstIterator.h"
/** Include structure for the diffusion. */
#include "itkDeformationFieldRegulizer.h"
#include "itkVectorMeanDiffusionImageFilter.h"
#include "itkImageFileReader.h"
#include "itkImageFileWriter.h"
#include "itkResampleImageFilter.h"
#include "itkCastImageFilter.h"
#include "itkMaximumImageFilter.h"
#include "itkImageRegionIterator.h"
#include "itkBSplineInterpolateImageFunction.h"
namespace elastix
{
/**
* \class BSplineTransformWithDiffusion
* \brief This class combines a B-spline transform with the
* diffusion/filtering of the deformation field.
*
* Every n iterations the deformation field is diffused using the
* VectorMeanDiffusionImageFilter. The total transformation of a point
* is determined by adding the B-spline deformation to the
* deformation field arrow. Filtering of the deformation field is based
* on some 'stiffness coefficient' image.
*
* \todo: this Transform has not been tested for images with Direction cosines
* matrix other than the identity matrix.
*
* \warning Using this transform in with the option
* (HowToCombineTranforms "Compose"). May give unpredictable results.
* Especially if the initial transformation is large. This is because
* the coefficient grid is not properly initialized.
* Better use (HowToCombineTranforms "Add").
*
* The parameters used in this class are:
* \parameter Transform: Select this transform as follows:\n
* <tt>(%Transform "BSplineTransformWithDiffusion")</tt>
* \parameter FinalGridSpacing: the grid spacing of the B-spline transform
* part of this transform for each dimension. \n
* example: <tt>(FinalGridSpacing 8.0 8.0 8.0)</tt>
* If only one argument is given, that factor is used for each dimension. The spacing
* is not in millimeters, but in "voxel size units".
* The default is 8.0 in every dimension.
* \parameter UpsampleGridOption: whether or not the B-spline grid should
* be upsampled from one resolution level to another. Choose from {true, false}. \n
* example: <tt>(UpsampleGridOption "true")</tt>
* The default is "true".
* \parameter FilterPattern: defines according to what schedule/pattern
* the deformation field should be filtered. Choose from {1,2}, where
* FilterPattern 1 is diffusion every "DiffusionEachNIterations" iterations,
* and where FilterPattern 2 filters more frequent in the beginning
* and less frequent at the end of a resolution. \n
* example: <tt>(FilterPattern 1)</tt>
* The default is filter pattern 1.
* \parameter DiffusionEachNIterations: defines for FilterPattern 1 after how
* many iterations of the optimiser there should be a filtering step. \n
* example: <tt>(DiffusionEachNIterations 5)</tt>
* The default is 1.
* \parameter AfterIterations: defines for FilterPattern 2 after how many
* iterations of the optimiser the filter frequency should be increased. \n
* example: <tt>(AfterIterations 100 200)</tt>
* The default is 50 and 100.
* \parameter HowManyIterations: defines to what frequency the filtering
* should be increased. \n
* example: <tt>(HowManyIterations 1 5 10)</tt>
* The default is 1, 5 and 10.
* \parameter NumberOfDiffusionIterations: defines the number of times
* the adaptive filtering is performed. \n
* example: <tt>(NumberOfDiffusionIterations 10)</tt>
* The default is 1.
* \parameter Radius: defines the radius of the filter. \n
* example: <tt>(Radius 1)</tt>
* The default is 1.
* \parameter ThresholdBool: defines whether or not the stiffness coefficient
* image should be thresholded. Choose from {true, false}. \n
* example: <tt>(ThresholdBool "true")</tt>
* The default is "true".
* \parameter ThresholdHU: if it is thresholded, this defines the threshold in
* Houndsfield units. \n
* example: <tt>(ThresholdHU 150)</tt>
* The default is 150.
* \parameter WriteDiffusionFiles: defines whether or not the stiffness coefficient
* image, the deformation field and the filtered field should be written
* to file. Choose from {true, false}. \n
* example: <tt>(WriteDiffusionFiles "true")</tt>
* The default is "false".
* \parameter GrayValueImageAlsoBasedOnFixedImage: defines whether or not
* the stiffness coefficient image should also be based on the fixed image.
* Choose from {true, false}. \n
* example: <tt>(GrayValueImageAlsoBasedOnFixedImage "true")</tt>
* The default is "true".
* \parameter UseFixedSegmentation: defines whether or not the stiffness coefficient
* image should be based on some prior defined segmentation of rigid structures in
* the fixed image, instead on a thresholding. Choose from {true, false}. \n
* example: <tt>(UseFixedSegmentation "true")</tt>
* The default is "false".
* \parameter FixedSegmentationFileName: the filename of this segmentation. \n
* example: <tt>(FixedSegmentationFileName "somestring")</tt>
* \parameter UseMovingSegmentation: defines whether or not the stiffness coefficient
* image should be based on some prior defined segmentation of rigid structures in
* the moving image, instead on a thresholding. Choose from {true, false}. \n
* example: <tt>(UseMovingSegmentation "true")</tt>
* The default is "false".
* \parameter MovingSegmentationFileName: the filename of this segmentation. \n
* example: <tt>(MovingSegmentationFileName "somestring")</tt>
* \parameter DefaultPixelValueForGVI: the default pixel value, when resampling
* the grayvalueimage.
* example: <tt>(DefaultPixelValueForGVI 0)</tt>
* The default is 0.
*
* The transform parameters necessary for transformix, additionally defined by this class, are:
* \transformparameter DeformationFieldFileName: stores the name of the deformation field. \n
* example: <tt>(DeformationFieldFileName "defField.mhd")</tt>
* \transformparameter GridSize: stores the size of the B-spline grid. \n
* example: <tt>(GridSize 16 16 16)</tt>
* \transformparameter GridIndex: stores the index of the B-spline grid. \n
* example: <tt>(GridIndex 0 0 0)</tt>
* \transformparameter GridSpacing: stores the spacing of the B-spline grid. \n
* example: <tt>(GridSpacing 16.0 16.0 16.0)</tt>
* \transformparameter GridOrigin: stores the origin of the B-spline grid. \n
* example: <tt>(GridOrigin 0.0 0.0 0.0)</tt>
*
* \ingroup Transforms
*/
template <class TElastix>
class ITK_TEMPLATE_EXPORT BSplineTransformWithDiffusion
: public itk::DeformationFieldRegulizer<itk::AdvancedCombinationTransform<
// BSplineCombinationTransform<
typename elx::TransformBase<TElastix>::CoordRepType,
elx::TransformBase<TElastix>::FixedImageDimension>>
,
// elx::TransformBase<TElastix>::FixedImageDimension, __VSplineOrder > >,
public TransformBase<TElastix>
{
public:
ITK_DISALLOW_COPY_AND_MOVE(BSplineTransformWithDiffusion);
/** Standard ITK-stuff. */
using Self = BSplineTransformWithDiffusion;
using Superclass1 = itk::DeformationFieldRegulizer<
itk::AdvancedCombinationTransform<typename elx::TransformBase<TElastix>::CoordRepType,
elx::TransformBase<TElastix>::FixedImageDimension>>;
using Superclass2 = elx::TransformBase<TElastix>;
/** The ITK-class that provides most of the functionality, and
* that is set as the "CurrentTransform" in the CombinationTransform.
*/
using BSplineTransformType =
itk::AdvancedBSplineDeformableTransform<typename elx::TransformBase<TElastix>::CoordRepType,
elx::TransformBase<TElastix>::FixedImageDimension,
3>;
using Pointer = itk::SmartPointer<Self>;
using ConstPointer = itk::SmartPointer<const Self>;
/** Method for creation through the object factory. */
itkNewMacro(Self);
/** Run-time type information (and related methods). */
itkTypeMacro(BSplineTransformWithDiffusion, itk::DeformationFieldRegulizer);
/** Name of this class.
* Use this name in the parameter file to select this specific transform. \n
* example: <tt>(Transform "BSplineTransformWithDiffusion")</tt>\n
*/
elxClassNameMacro("BSplineTransformWithDiffusion");
/** Dimension of the domain space. */
itkStaticConstMacro(SpaceDimension, unsigned int, Superclass2::FixedImageDimension);
/** The B-spline order. */
itkStaticConstMacro(SplineOrder, unsigned int, __VSplineOrder);
/** Typedefs inherited from the superclass. */
using typename Superclass1::ScalarType;
using typename Superclass1::ParametersType;
using typename Superclass1::JacobianType;
using typename Superclass1::InputVectorType;
using typename Superclass1::OutputVectorType;
using typename Superclass1::InputCovariantVectorType;
using typename Superclass1::OutputCovariantVectorType;
using typename Superclass1::InputVnlVectorType;
using typename Superclass1::OutputVnlVectorType;
using typename Superclass1::InputPointType;
using typename Superclass1::OutputPointType;
/** Typedef's specific for the BSplineTransform. */
using PixelType = typename BSplineTransformType::PixelType;
using ImageType = typename BSplineTransformType::ImageType;
using ImagePointer = typename BSplineTransformType::ImagePointer;
using RegionType = typename BSplineTransformType::RegionType;
using IndexType = typename BSplineTransformType::IndexType;
using SizeType = typename BSplineTransformType::SizeType;
using SpacingType = typename BSplineTransformType::SpacingType;
using OriginType = typename BSplineTransformType::OriginType;
using WeightsFunctionType = typename BSplineTransformType::WeightsFunctionType;
using WeightsType = typename BSplineTransformType::WeightsType;
using ContinuousIndexType = typename BSplineTransformType::ContinuousIndexType;
using ParameterIndexArrayType = typename BSplineTransformType::ParameterIndexArrayType;
/** Typedef's from TransformBase. */
using typename Superclass2::ElastixType;
using typename Superclass2::ParameterMapType;
using typename Superclass2::RegistrationType;
using typename Superclass2::CoordRepType;
using typename Superclass2::FixedImageType;
using typename Superclass2::MovingImageType;
using ITKBaseType = typename Superclass2::ITKBaseType;
using CombinationTransformType = typename Superclass2::CombinationTransformType;
/** Other typedef's inherited from Superclass1. */
using typename Superclass1::IntermediaryDFTransformType;
using typename Superclass1::VectorImageType;
using VectorImagePointer = typename VectorImageType::Pointer;
/** References to the fixed and moving image types. */
using FixedImageELXType = typename ElastixType::FixedImageType;
using MovingImageELXType = typename ElastixType::MovingImageType;
/** Other typedef's.*/
using DummyImageType = itk::Image<short, Self::SpaceDimension>;
using DummyIteratorType = itk::ImageRegionConstIterator<DummyImageType>;
using BSplineTransformPointer = typename BSplineTransformType::Pointer;
using GenericDeformationFieldRegulizer = typename Superclass1::Superclass;
/** Typedef's for the diffusion of the deformation field. */
using VectorReaderType = itk::ImageFileReader<VectorImageType>;
using VectorType = typename VectorImageType::PixelType;
using VectorImageIteratorType = itk::ImageRegionIterator<VectorImageType>;
using GrayValueImageType = FixedImageELXType;
using GrayValueImagePointer = typename GrayValueImageType::Pointer;
using GrayValuePixelType = typename GrayValueImageType::PixelType;
using GrayValueImageIteratorType = itk::ImageRegionIterator<GrayValueImageType>;
using MaximumImageFilterType = itk::MaximumImageFilter<GrayValueImageType, GrayValueImageType, GrayValueImageType>;
using DiffusionFilterType = itk::VectorMeanDiffusionImageFilter<VectorImageType, GrayValueImageType>;
using DiffusionFilterPointer = typename DiffusionFilterType::Pointer;
using RadiusType = typename VectorImageType::SizeType;
using ResamplerType1 = itk::ResampleImageFilter<MovingImageELXType, GrayValueImageType, CoordRepType>;
using ResamplerPointer1 = typename ResamplerType1::Pointer;
using ResamplerType2 = itk::ResampleImageFilter<GrayValueImageType, GrayValueImageType, CoordRepType>;
using ResamplerPointer2 = typename ResamplerType2::Pointer;
using InterpolatorType = itk::BSplineInterpolateImageFunction<GrayValueImageType>;
using InterpolatorPointer = typename InterpolatorType::Pointer;
using GrayValueImageReaderType = itk::ImageFileReader<GrayValueImageType>;
using GrayValueImageReaderPointer = typename GrayValueImageReaderType::Pointer;
/** Execute stuff before the actual registration:
* \li Create an initial B-spline grid.
* \li Create initial registration parameters.
* \li Setup stuff for the diffusion of the deformation field.
*/
void
BeforeRegistration() override;
/** Execute stuff before each new pyramid resolution:
* \li upsample the B-spline grid.
*/
void
BeforeEachResolution() override;
/** Execute stuff after each iteration:
* \li Do a diffusion of the deformation field.
*/
void
AfterEachIteration() override;
/** Execute stuff after registration:
* \li Destroy things that are not needed anymore in order to free memory.
*/
void
AfterRegistration() override;
/** Set the initial B-spline grid. */
virtual void
SetInitialGrid(bool upsampleGridOption);
/** Upsample the B-spline grid. */
virtual void
IncreaseScale();
/** Function to read transform-parameters from a file. */
void
ReadFromFile() override;
/** Diffuse the deformation field. */
void
DiffuseDeformationField();
/** Method to transform a point.
* This method just calls the implementation from the
* GenericDeformationFieldRegulizer. This is necessary, since:
* The DeformationFieldRegulizerFor is used which expects
* that its template argument is a BSplineDeformableTransform. This is
* not the case, because we gave it a BSplineCombinationTransform.
* This last class has a slightly different behavior of the
* TransformPoint() method (it does not call the TransformPoint() with
* with 5 arguments, as the BSplineDeformableTransform does).
*/
OutputPointType
TransformPoint(const InputPointType & point) const override;
/** Method to transform a point with extra arguments. Just calls
* the Superclass1's implementation. Has to be present here since it is an
* overloaded function.
*
virtual void TransformPoint(
const InputPointType & inputPoint,
OutputPointType & outputPoint,
WeightsType & weights,
ParameterIndexArrayType & indices,
bool & inside ) const;*/
protected:
/** The constructor. */
BSplineTransformWithDiffusion();
/** The destructor. */
~BSplineTransformWithDiffusion() override = default;
/** Member variables. */
SpacingType m_GridSpacingFactor;
private:
elxOverrideGetSelfMacro;
/** Creates a map of the parameters specific for this (derived) transform type. */
ParameterMapType
CreateDerivedTransformParameterMap() const override;
/** Writes its deformation field to a file. */
void
WriteDerivedTransformDataToFile() const override;
/** Member variables for diffusion. */
DiffusionFilterPointer m_Diffusion;
VectorImagePointer m_DeformationField;
VectorImagePointer m_DiffusedField;
GrayValueImagePointer m_GrayValueImage1;
GrayValueImagePointer m_GrayValueImage2;
GrayValueImagePointer m_MovingSegmentationImage;
GrayValueImagePointer m_FixedSegmentationImage;
GrayValueImageReaderPointer m_MovingSegmentationReader;
GrayValueImageReaderPointer m_FixedSegmentationReader;
std::string m_MovingSegmentationFileName;
std::string m_FixedSegmentationFileName;
ResamplerPointer1 m_Resampler1;
ResamplerPointer2 m_Resampler2;
InterpolatorPointer m_Interpolator;
RegionType m_DeformationRegion;
OriginType m_DeformationOrigin;
SpacingType m_DeformationSpacing;
/** Member variables for writing diffusion files. */
bool m_WriteDiffusionFiles;
bool m_AlsoFixed;
bool m_ThresholdBool;
GrayValuePixelType m_ThresholdHU;
bool m_UseMovingSegmentation;
bool m_UseFixedSegmentation;
/** The B-spline parameters, which is going to be filled with zeros. */
ParametersType m_BSplineParameters;
/** The internal BSplineTransform, set as a current transform in
* the combination transform.
*/
BSplineTransformPointer m_BSplineTransform;
};
} // end namespace elastix
#ifndef ITK_MANUAL_INSTANTIATION
# include "elxBSplineTransformWithDiffusion.hxx"
#endif
#endif // end #ifndef elxBSplineTransformWithDiffusion_h
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