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/****************************************************************\
* *
* C4 dynamic programming library - optimal alignment code *
* *
* Guy St.C. Slater.. mailto:guy@ebi.ac.uk *
* Copyright (C) 2000-2008. All Rights Reserved. *
* *
* This source code is distributed under the terms of the *
* GNU General Public License, version 3. See the file COPYING *
* or http://www.gnu.org/licenses/gpl.txt for details *
* *
* If you use this code, please keep this notice intact. *
* *
\****************************************************************/
#include <string.h> /* For strlen() */
#include "slist.h"
#include "optimal.h"
Optimal *Optimal_create(C4_Model *model, gchar *name,
Optimal_Type type, gboolean use_codegen){
register Optimal *optimal = g_new0(Optimal, 1);
register gchar *viterbi_name;
g_assert(model);
g_assert(!model->is_open);
optimal->ref_count = 1;
if(name)
optimal->name = g_strdup(name);
else
optimal->name = g_strdup_printf("optimal:%s", model->name);
optimal->type = type;
if(type & Optimal_Type_SCORE){
viterbi_name = g_strconcat(optimal->name, " find score", NULL);
optimal->find_score = Viterbi_create(model, viterbi_name,
Viterbi_Mode_FIND_SCORE, FALSE,
use_codegen);
g_free(viterbi_name);
}
if(type & Optimal_Type_PATH){
viterbi_name = g_strconcat(optimal->name, " find path", NULL);
optimal->find_path = Viterbi_create(model, viterbi_name,
Viterbi_Mode_FIND_PATH, FALSE,
use_codegen);
g_free(viterbi_name);
}
if(type & Optimal_Type_REDUCED_SPACE){
if(!C4_Model_is_global(model)){
viterbi_name = g_strconcat(optimal->name, " find region",
NULL);
optimal->find_region = Viterbi_create(model, viterbi_name,
Viterbi_Mode_FIND_REGION, FALSE,
use_codegen);
g_free(viterbi_name);
}
viterbi_name = g_strconcat(optimal->name,
" find checkpoint", NULL);
optimal->find_checkpoint_continuation
= Viterbi_create(model, viterbi_name,
Viterbi_Mode_FIND_CHECKPOINTS, TRUE, use_codegen);
g_free(viterbi_name);
viterbi_name = g_strconcat(optimal->name,
" find path continuation", NULL);
optimal->find_path_continuation
= Viterbi_create(model, viterbi_name,
Viterbi_Mode_FIND_PATH, TRUE, use_codegen);
g_free(viterbi_name);
/**/
}
return optimal;
}
/* FIXME: name should not be model->name + suffix,
* but optimal->name + suffix
*/
void Optimal_destroy(Optimal *optimal){
g_assert(optimal);
if(--optimal->ref_count)
return;
if(optimal->find_score)
Viterbi_destroy(optimal->find_score);
if(optimal->find_path)
Viterbi_destroy(optimal->find_path);
if(optimal->find_region)
Viterbi_destroy(optimal->find_region);
if(optimal->find_checkpoint_continuation)
Viterbi_destroy(optimal->find_checkpoint_continuation);
if(optimal->find_path_continuation)
Viterbi_destroy(optimal->find_path_continuation);
g_free(optimal->name);
g_free(optimal);
return;
}
Optimal *Optimal_share(Optimal *optimal){
g_assert(optimal);
optimal->ref_count++;
return optimal;
}
static void Optimal_add_codegen(Viterbi *viterbi,
GPtrArray *codegen_list){
register Codegen *codegen;
if(viterbi){
codegen = Viterbi_make_Codegen(viterbi);
g_ptr_array_add(codegen_list, codegen);
}
return;
}
GPtrArray *Optimal_make_Codegen_list(Optimal *optimal){
register GPtrArray *codegen_list = g_ptr_array_new();
Optimal_add_codegen(optimal->find_score, codegen_list);
Optimal_add_codegen(optimal->find_path, codegen_list);
Optimal_add_codegen(optimal->find_region, codegen_list);
Optimal_add_codegen(optimal->find_checkpoint_continuation,
codegen_list);
Optimal_add_codegen(optimal->find_path_continuation, codegen_list);
g_assert(codegen_list->len);
return codegen_list;
}
C4_Score Optimal_find_score(Optimal *optimal, Region *region,
gpointer user_data, SubOpt *subopt){
register C4_Score score;
register Viterbi_Data *vd;
g_assert(optimal->find_score);
vd = Viterbi_Data_create(optimal->find_score, region);
score = Viterbi_calculate(optimal->find_score, region,
vd, user_data, subopt);
Viterbi_Data_destroy(vd);
return score;
}
static Region *Optimal_find_region(Optimal *optimal, Region *region,
gpointer user_data, C4_Score threshold,
SubOpt *subopt, C4_Score *region_score){
register Region *alignment_region;
register Viterbi_Data *vd;
register C4_Score score;
g_assert(optimal->type & Optimal_Type_REDUCED_SPACE);
if(!optimal->find_region) /* Must be a global model */
return Region_share(region); /* Already know region */
g_assert(optimal->find_region);
vd = Viterbi_Data_create(optimal->find_region, region);
score = Viterbi_calculate(optimal->find_region, region,
vd, user_data, subopt);
if(score < threshold)
return NULL;
alignment_region = Region_share(vd->alignment_region);
(*region_score) = score;
g_assert(Region_is_valid(alignment_region));
g_assert(Region_is_within(region, alignment_region));
Viterbi_Data_destroy(vd);
return alignment_region;
}
/**/
static C4_Score Optimal_find_checkpoints_continuation(Optimal *optimal,
Region *region, gpointer user_data,
SubOpt *subopt, GPtrArray **sub_vsa_list,
C4_State *first_state, C4_Score *first_cell,
C4_State *final_state, C4_Score *final_cell){
register C4_Score score = C4_IMPOSSIBLY_LOW_SCORE;
register Viterbi_Data *vd;
vd = Viterbi_Data_create(optimal->find_checkpoint_continuation,
region);
g_assert(vd->checkpoint);
g_assert(!vd->continuation);
Viterbi_Data_set_continuation(vd, first_state, first_cell,
final_state, final_cell);
g_assert(vd->continuation);
score = Viterbi_calculate(optimal->find_checkpoint_continuation,
region, vd, user_data, subopt);
(*sub_vsa_list) = Viterbi_Checkpoint_traceback(
optimal->find_checkpoint_continuation,
vd, region, first_state, final_cell);
Viterbi_Data_destroy(vd);
return score;
}
static C4_Score Optimal_find_checkpoints_recur(Optimal *optimal,
Region *region, gpointer user_data,
SubOpt *subopt, SList *vsa_list,
C4_State *first_state, C4_Score *first_cell,
C4_State *final_state, C4_Score *final_cell){
register Viterbi_SubAlignment *vsa, *prev_vsa = NULL,
*next_vsa;
register C4_Score *sub_first_cell;
register C4_State *sub_final_state;
register C4_Score score;
register gint i;
register gboolean used_vsa = TRUE, prev_used_vsa = TRUE;
GPtrArray *sub_vsa_list = NULL;
score = Optimal_find_checkpoints_continuation(
optimal, region, user_data, subopt, &sub_vsa_list,
first_state, first_cell, final_state, final_cell);
g_assert(sub_vsa_list);
for(i = sub_vsa_list->len-1; i >= 0; i--){
vsa = sub_vsa_list->pdata[i];
g_assert(vsa);
if(Viterbi_use_reduced_space(optimal->find_path, vsa->region)){
sub_first_cell = prev_vsa
? prev_vsa->final_cell
: first_cell;
if(i){
next_vsa = sub_vsa_list->pdata[i-1];
g_assert(next_vsa);
sub_final_state = next_vsa->first_state;
} else {
sub_final_state = final_state;
}
Optimal_find_checkpoints_recur(optimal,
vsa->region, user_data, subopt, vsa_list,
vsa->first_state, sub_first_cell,
sub_final_state, vsa->final_cell);
used_vsa = FALSE;
} else {
SList_queue(vsa_list, vsa);
used_vsa = TRUE;
}
if(prev_vsa && (!prev_used_vsa))
Viterbi_SubAlignment_destroy(prev_vsa);
prev_vsa = vsa;
prev_used_vsa = used_vsa;
}
g_ptr_array_free(sub_vsa_list, TRUE);
return score;
}
static Alignment *Optimal_find_path_quadratic_space_continuation(
Optimal *optimal, Region *region,
gpointer user_data, SubOpt *subopt,
C4_State *first_state, C4_Score *first_cell,
C4_State *final_state, C4_Score *final_cell){
register Alignment *alignment;
register C4_Score score;
register Viterbi_Data *vd
= Viterbi_Data_create(optimal->find_path_continuation, region);
register AlignmentOperation *ao;
g_assert(!Viterbi_use_reduced_space(optimal->find_path, region));
Viterbi_Data_set_continuation(vd, first_state, first_cell,
final_state, final_cell);
score = Viterbi_calculate(optimal->find_path_continuation,
region, vd, user_data, subopt);
g_assert(vd->curr_query_end == region->query_length);
g_assert(vd->curr_target_end == region->target_length);
g_assert(vd->continuation->final_cell[0] == score);
alignment = Viterbi_Data_create_Alignment(vd,
optimal->find_path_continuation->model,
score, region);
ao = alignment->operation_list->pdata[0];
g_assert(ao);
g_assert(first_state->id == ao->transition->input->id);
ao = alignment->operation_list->pdata
[alignment->operation_list->len-1];
g_assert(ao);
g_assert(final_state->id == ao->transition->output->id);
Viterbi_Data_clear_continuation(vd);
g_assert(score == alignment->score);
Viterbi_Data_destroy(vd);
return alignment;
}
static Alignment *Optimal_compute_subalignments(Optimal *optimal,
Region *region, gpointer user_data,
SubOpt *subopt,
SList *vsa_list, C4_Score score, gint cell_size){
register gint i;
register Viterbi_SubAlignment *vsa = NULL;
register Alignment *sub_alignment, *alignment;
register AlignmentOperation *ao;
register C4_State *sub_final_state;
register C4_Score *sub_first_cell;
register SListNode *node;
register C4_Transition *transition;
register C4_Score *dummy_cell = g_new0(C4_Score, cell_size);
alignment = Alignment_create(optimal->find_path->model,
region, score);
SList_for_each(vsa_list, node){
if(vsa){
sub_first_cell = vsa->final_cell;
} else {
sub_first_cell = dummy_cell;
}
if(node->next){
vsa = node->next->data;
g_assert(vsa);
sub_final_state = vsa->first_state;
} else {
sub_final_state = optimal->find_checkpoint_continuation
->model->end_state->state;
}
vsa = node->data;
g_assert(vsa);
g_assert(vsa->region);
sub_alignment = Optimal_find_path_quadratic_space_continuation(
optimal, vsa->region, user_data, subopt,
vsa->first_state, sub_first_cell,
sub_final_state, vsa->final_cell);
for(i = 0; i < sub_alignment->operation_list->len; i++){
ao = sub_alignment->operation_list->pdata[i];
/* Map transitions back to find_path model */
transition = optimal->find_path->model->transition_list->pdata
[ao->transition->id];
Alignment_add(alignment, transition, ao->length);
}
Alignment_destroy(sub_alignment);
}
g_free(dummy_cell);
return alignment;
}
static Alignment *Optimal_find_path_reduced_space(Optimal *optimal,
Region *region, gpointer user_data, SubOpt *subopt){
register Alignment *alignment;
register SListSet *slist_set = SListSet_create();
register SList *vsa_list = SList_create(slist_set);
register SListNode *node;
register gint cell_size
= optimal->find_checkpoint_continuation->cell_size;
register C4_Score score,
*dummy_first_cell = g_new0(C4_Score, cell_size),
*dummy_final_cell = g_new0(C4_Score, cell_size);
register C4_Model *model;
register Viterbi_SubAlignment *vsa;
g_assert(Viterbi_use_reduced_space(optimal->find_path, region));
model = optimal->find_checkpoint_continuation->model;
score = Optimal_find_checkpoints_recur(optimal,
region, user_data, subopt, vsa_list,
model->start_state->state, dummy_first_cell,
model->end_state->state, dummy_final_cell);
alignment = Optimal_compute_subalignments(optimal, region,
user_data, subopt, vsa_list, score, cell_size);
SList_for_each(vsa_list, node){
vsa = node->data;
Viterbi_SubAlignment_destroy(vsa);
}
SList_destroy(vsa_list);
SListSet_destroy(slist_set);
g_free(dummy_first_cell);
g_free(dummy_final_cell);
return alignment;
}
/**/
static Alignment *Optimal_find_path_quadratic_space(
Optimal *optimal, Region *region, gpointer user_data,
SubOpt *subopt){
register Alignment *alignment;
register C4_Score score;
register Viterbi_Data *vd = Viterbi_Data_create(optimal->find_path,
region);
g_assert(!Viterbi_use_reduced_space(optimal->find_path, region));
score = Viterbi_calculate(optimal->find_path, region,
vd, user_data, subopt);
alignment = Viterbi_Data_create_Alignment(vd,
optimal->find_path->model, score, region);
g_assert(score == alignment->score);
Viterbi_Data_destroy(vd);
return alignment;
}
/**/
Alignment *Optimal_find_path(Optimal *optimal, Region *region,
gpointer user_data, C4_Score threshold,
SubOpt *subopt){
register Alignment *alignment = NULL;
register Region *alignment_region;
C4_Score region_score = C4_IMPOSSIBLY_LOW_SCORE;
/**/
g_assert(!optimal->find_path->model->is_open);
if(Viterbi_use_reduced_space(optimal->find_path, region)){
alignment_region = Optimal_find_region(optimal, region,
user_data, threshold, subopt,
®ion_score);
if(!alignment_region) /* No region when score below threshold */
return NULL;
if(Viterbi_use_reduced_space(optimal->find_path,
alignment_region)){
alignment = Optimal_find_path_reduced_space(optimal,
alignment_region, user_data, subopt);
} else {
alignment = Optimal_find_path_quadratic_space(
optimal, alignment_region,
user_data, subopt);
}
g_assert(alignment);
g_assert(Region_is_same(alignment_region, alignment->region));
#ifndef G_DISABLE_ASSERT
if(alignment->score != region_score){
g_warning("Region score DIFF have:[%d] expect:[%d]",
alignment->score, region_score);
}
#endif /* G_DISABLE_ASSERT */
g_assert(alignment->score == region_score);
Region_destroy(alignment_region);
} else {
alignment = Optimal_find_path_quadratic_space(
optimal, region, user_data, subopt);
}
g_assert(optimal->find_path);
g_assert(alignment->model == optimal->find_path->model);
g_assert(Alignment_is_valid(alignment, region, user_data));
if(alignment->score < threshold){
Alignment_destroy(alignment);
return NULL;
}
return alignment;
}
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