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//genesis
/* FILE INFORMATION
** Several versions of Mitral cell voltage-dependent channels.
** Implemented by : Upinder S. Bhalla.
**
** The mitral cell channels have been adapted from Traub's channels for
** the hippocampal pyramidal cell :
** R.D.Traub, Neuroscience Vol 7 No 5 pp 1233-1242 (1982)
**
** This file depends on functions and constants defined in defaults.g
*/
// CONSTANTS
/* mitral cell resting potl */
float EREST_ACT = -0.065
float ENA = 0.045
float EK = -0.090
float ECA = 0.070
float SOMA_A = 1e-9 /* Square meters */
//========================================================================
// Super-Fast Tabchan versions of Mitral cell channels
//========================================================================
// Tabchan Na Mitral cell channel
//========================================================================
function make_Na_mit_tchan
if (({exists Na_mit_tchan}))
return
end
create tabchannel Na_mit_tchan
setfield ^ Ek {ENA} Gbar {1.2e3*SOMA_A} Ik 0 Gk 0 \
Xpower 3 Ypower 1 Zpower 0
setupalpha Na_mit_tchan X {320e3*(0.013 + EREST_ACT)} -320e3 \
-1.0 {-1.0*(0.013 + EREST_ACT)} -0.004 \
{-280e3*(0.040 + EREST_ACT)} 280e3 -1.0 \
{-1.0*(0.040 + EREST_ACT)} 5.0e-3
setupalpha Na_mit_tchan Y 128.0 0.0 0.0 \
{-1.0*(0.017 + EREST_ACT)} 0.018 4.0e3 0.0 1.0 \
{-1.0*(0.040 + EREST_ACT)} -5.0e-3
end
//========================================================================
// Tabchan version of K channel - psuedo-traub
//========================================================================
function make_K_mit_tchan
if (({exists K_mit_tchan}))
return
end
create tabchannel K_mit_tchan
setfield ^ Ek {EK} Gbar {360.0*SOMA_A} Ik 0 Gk 0 \
Xpower 4 Ypower 0 Zpower 0
setupalpha K_mit_tchan X {32e3*(0.015 + EREST_ACT)} -32e3 \
-1.0 {-1.0*(0.015 + EREST_ACT)} -0.005 500.0 0.0 0.0 \
{-1.0*(0.010 + EREST_ACT)} 40.0e-3
end
//========================================================================
// Tabulated Ca dependent K - channel.
//========================================================================
function make_Kca_mit_tab
if (({exists Kca_mit_tab}))
return
end
float EK = -0.08
create vdep_channel Kca_mit_tab
setfield ^ Ek {EK} gbar {360.0*SOMA_A} Ik 0 Gk 0
create table Kca_mit_tab/qv
call Kca_mit_tab/qv TABCREATE 100 -0.1 0.1
int i
float x, dx, y
x = -0.1
dx = 0.2/100.0
for (i = 0; i <= 100; i = i + 1)
y = {exp {(x - EREST_ACT)/0.027}}
setfield Kca_mit_tab/qv table->table[{i}] {y}
x = x + dx
end
create tabgate Kca_mit_tab/qca
setupgate Kca_mit_tab/qca alpha {5.0e5*0.01500} \
-5.0e5 -1.0 -0.01500 -0.00130 -size 1000 -range 0.0 0.01
call Kca_mit_tab/qca TABCREATE beta 1 -1 100
setfield Kca_mit_tab/qca beta->table[0] 5.0e1
setfield Kca_mit_tab/qca beta->table[1] 5.0e1
addmsg Kca_mit_tab/qv Kca_mit_tab/qca PRD_ALPHA output
addmsg Kca_mit_tab/qca Kca_mit_tab MULTGATE m 1
addfield Kca_mit_tab addmsg1
addfield Kca_mit_tab addmsg2
setfield Kca_mit_tab \
addmsg1 "../Ca_mit_conc qca VOLTAGE Ca" \
addmsg2 ".. qv INPUT Vm"
end
//========================================================================
// Tabulated Ca Channel - mitral cell
//========================================================================
function make_Ca_mit_tab
if (({exists Ca_mit_tab}))
return
end
create vdep_channel Ca_mit_tab
setfield ^ Ek {ECA} gbar {1.2e3*SOMA_A} Ik 0 Gk 0
create tabgate Ca_mit_tab/s
/* there is a singularity at x=0, so I hack around that by using
** an odd number of sample points */
setup_table Ca_mit_tab/s alpha 101 {40e3*(0.060 + EREST_ACT)} \
-40e3 -1.0 {-1.0*(0.060 + EREST_ACT)} -0.010
setup_table Ca_mit_tab/s beta 101 {-5e3*(0.045 + EREST_ACT)} 5e3 \
-1.0 {-1.0*(0.045 + EREST_ACT)} 10.0e-3
create tabgate Ca_mit_tab/r
call Ca_mit_tab/r TABCREATE alpha 1 -1 1000
setfield Ca_mit_tab/r alpha->table[0] 5.0
setfield Ca_mit_tab/r alpha->table[1] 5.0
setupgate Ca_mit_tab/r beta {25.0*200.0} -25.0 \
-1.0 -200.0 -20.0 -size 1000 -range -1 1000
/*
create Ca_concen Ca_mit_tab/conc
set Ca_mit_tab/conc \
tau 0.01 \ // sec
B {5.2e-6/(SOMA_XA* \
SOMA_L)} \ // Curr to conc
Ca_base 0.0
*/
addmsg Ca_mit_tab/s Ca_mit_tab MULTGATE m 5
addmsg Ca_mit_tab/r Ca_mit_tab MULTGATE m 1
addfield Ca_mit_tab addmsg1
addfield Ca_mit_tab addmsg2
addfield Ca_mit_tab addmsg3
setfield Ca_mit_tab \
addmsg1 "../Ca_mit_conc r VOLTAGE Ca" \
addmsg2 ". ../Ca_mit_conc I_Ca Ik" \
addmsg3 ".. s VOLTAGE Vm"
end
//========================================================================
// Ca conc - mitral cell
//========================================================================
function make_Ca_mit_conc
if (({exists Ca_mit_conc}))
return
end
create Ca_concen Ca_mit_conc
// sec
// Curr to conc
setfield Ca_mit_conc tau 0.01 B 5.2e-6 Ca_base 0.00001
end
//========================================================================
// ACTIVE NA CHANNEL - MITRAL
//========================================================================
function make_Na_mit_hh
if (({exists Na_mit_hh}))
return
end
create hh_channel Na_mit_hh
setfield Na_mit_hh Ek {ENA} Gbar {1.2e3*SOMA_A} Xpower 3.0 \
Ypower 1.0 X_alpha_FORM {LINOID} X_alpha_A -0.32e6 \
X_alpha_B -0.004 X_alpha_V0 {0.013 + EREST_ACT} \
X_beta_FORM {LINOID} X_beta_A 0.28e6 X_beta_B 5.0e-3 \
X_beta_V0 {40.0e-3 + EREST_ACT} Y_alpha_FORM {EXPONENTIAL} \
Y_alpha_A 128.0 Y_alpha_B -18.0e-3 \
Y_alpha_V0 {0.017 + EREST_ACT} Y_beta_FORM {SIGMOID} \
Y_beta_A 4.0e3 Y_beta_B -5.0e-3 \
Y_beta_V0 {40.0e-3 + EREST_ACT}
end
//========================================================================
// ACTIVE K CHANNEL - MITRAL
//========================================================================
function make_K_mit_hh
if (({exists K_mit_hh}))
return
end
create hh_channel K_mit_hh
// this part can't work since Traub uses 2 exps to get the Y. So I set
// the Ypower to zero for now and ignore it.
setfield K_mit_hh Ek {EK} Gbar {360.0*SOMA_A} Xpower 4.0 \
Ypower 0.0 X_alpha_FORM {LINOID} X_alpha_A -32.0e3 \
X_alpha_B -5.0e-3 X_alpha_V0 {0.015 + EREST_ACT} \
X_beta_FORM {EXPONENTIAL} X_beta_A 500.0 X_beta_B -40.0e-3 \
X_beta_V0 {0.010 + EREST_ACT} Y_alpha_FORM {EXPONENTIAL} \
Y_alpha_A 128.0 Y_alpha_B -18.0e-3 \
Y_alpha_V0 {0.017 + EREST_ACT} Y_beta_FORM {SIGMOID} \
Y_beta_A 4.0e3 Y_beta_B -5.0e-3 \
Y_beta_V0 {40.0e-3 + EREST_ACT}
end
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