File: cutout.tex

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%\documentclass[12pt]{article}
%\usepackage{a4wide}
%\begin{document}

\unitlength1pt
%\fbox{
\begin{picture}(330,100)(0,5)
\put(110,45){$\approx$}
\put(255,45){$\approx$}
\put(155,100){EST/Protein sequence}
\put(105,90){$\overbrace{\hspace*{170pt}}$}
\put(0,70){
%\fbox{
\begin{picture}(330,30)(0,0)
\put(0,10){\begin{tabular}{@{}l}
             EST/Protein\\
             DB
             \end{tabular}}

\put(20,10){\rule[0.2pt]{310pt}{0.2pt}}

\put(120,5){\line(0,1){5}}
\put(118,12){$a$}
\put(168,13){$b$}
\put(170,5){\line(0,1){5}}
\put(120,10){\line(-1,-1){70}}
\put(170,10){\line(-1,-1){70}}

\put(196,5){\line(0,1){5}}
\put(194,13){$c$}
\put(244,13){$d$}
\put(246,5){\line(0,1){5}}
\put(196,10){\line(1,-1){70}}
\put(246,10){\line(1,-1){70}}
\end{picture}

%}%fbox
}
\put(0,0){%
%\fbox{
\begin{picture}(330,30)(0,0)
\put(0,10){\begin{tabular}{@{}l}
             genomic\\
             DNA
             \end{tabular}}

\put(20,10){\rule[0.2pt]{310pt}{0.2pt}}
\put(170,20){cut out}
\put(135,10){$\overbrace{\hspace*{100pt}}$}

\put(54,5){\line(0,1){5}}
\put(48,12){$A$}
\put(98,13){$B$}
\put(104,5){\line(0,1){5}}

\put(270,5){\line(0,1){5}}
\put(268,13){$C$}
\put(318,13){$D$}
\put(320,5){\line(0,1){5}}
\end{picture}
%}%fbox
}
\end{picture}
%}%fbox

%\end{document}