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/*=========================================================================
Program: Insight Segmentation & Registration Toolkit
Module: $RCSfile: DeformableRegistration14.cxx,v $
Language: C++
Date: $Date: 2009-06-24 12:08:59 $
Version: $Revision: 1.10 $
Copyright (c) Insight Software Consortium. All rights reserved.
See ITKCopyright.txt or http://www.itk.org/HTML/Copyright.htm for details.
This software is distributed WITHOUT ANY WARRANTY; without even
the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR
PURPOSE. See the above copyright notices for more information.
=========================================================================*/
#if defined(_MSC_VER)
#pragma warning ( disable : 4786 )
#endif
// Software Guide : BeginLatex
//
// This example illustrates the use of the \doxygen{RegularStepGradientDescentOptimizer}
// in the context of a deformable registration problem. The code of this example is almost
// identical to the one in Section~\ref{sec:DeformableRegistration8}.
//
// \index{itk::BSplineDeformableTransform}
// \index{itk::BSplineDeformableTransform!DeformableRegistration}
// \index{itk::RegularStepGradientDescentOptimizer}
//
//
// Software Guide : EndLatex
#include "itkImageRegistrationMethod.h"
#include "itkMattesMutualInformationImageToImageMetric.h"
#include "itkLinearInterpolateImageFunction.h"
#include "itkImage.h"
#include "itkTimeProbesCollectorBase.h"
#ifdef ITK_USE_REVIEW
#include "itkMemoryProbesCollectorBase.h"
#define itkProbesCreate() \
itk::TimeProbesCollectorBase chronometer; \
itk::MemoryProbesCollectorBase memorymeter
#define itkProbesStart( text ) memorymeter.Start( text ); chronometer.Start( text )
#define itkProbesStop( text ) chronometer.Stop( text ); memorymeter.Stop( text )
#define itkProbesReport( stream ) chronometer.Report( stream ); memorymeter.Report( stream )
#else
#define itkProbesCreate() \
itk::TimeProbesCollectorBase chronometer
#define itkProbesStart( text ) chronometer.Start( text )
#define itkProbesStop( text ) chronometer.Stop( text )
#define itkProbesReport( stream ) chronometer.Report( stream )
#endif
// Software Guide : BeginLatex
//
// The following are the most relevant headers to this example.
//
// \index{itk::BSplineDeformableTransform!header}
// \index{itk::RegularStepGradientDescentOptimizer!header}
//
// Software Guide : EndLatex
// Software Guide : BeginCodeSnippet
#include "itkBSplineDeformableTransform.h"
#include "itkRegularStepGradientDescentOptimizer.h"
// Software Guide : EndCodeSnippet
#include "itkImageFileReader.h"
#include "itkImageFileWriter.h"
#include "itkResampleImageFilter.h"
#include "itkCastImageFilter.h"
#include "itkSquaredDifferenceImageFilter.h"
#include "itkTransformFileReader.h"
// The following section of code implements a Command observer
// used to monitor the evolution of the registration process.
//
#include "itkCommand.h"
class CommandIterationUpdate : public itk::Command
{
public:
typedef CommandIterationUpdate Self;
typedef itk::Command Superclass;
typedef itk::SmartPointer<Self> Pointer;
itkNewMacro( Self );
protected:
CommandIterationUpdate() {};
public:
typedef itk::RegularStepGradientDescentOptimizer OptimizerType;
typedef const OptimizerType * OptimizerPointer;
void Execute(itk::Object *caller, const itk::EventObject & event)
{
Execute( (const itk::Object *)caller, event);
}
void Execute(const itk::Object * object, const itk::EventObject & event)
{
OptimizerPointer optimizer =
dynamic_cast< OptimizerPointer >( object );
if( !(itk::IterationEvent().CheckEvent( &event )) )
{
return;
}
std::cout << optimizer->GetCurrentIteration() << " ";
std::cout << optimizer->GetValue() << " ";
std::cout << std::endl;
}
};
int main( int argc, char *argv[] )
{
if( argc < 4 )
{
std::cerr << "Missing Parameters " << std::endl;
std::cerr << "Usage: " << argv[0];
std::cerr << " fixedImageFile movingImageFile outputImagefile ";
std::cerr << " [differenceOutputfile] [differenceBeforeRegistration] ";
std::cerr << " [deformationField] ";
std::cerr << " [useExplicitPDFderivatives ] [useCachingBSplineWeights ] ";
std::cerr << " [filenameForFinalTransformParameters] ";
std::cerr << " [maximumStepLength] [maximumNumberOfIterations]";
std::cerr << std::endl;
return EXIT_FAILURE;
}
const unsigned int ImageDimension = 3;
typedef signed short PixelType;
typedef itk::Image< PixelType, ImageDimension > FixedImageType;
typedef itk::Image< PixelType, ImageDimension > MovingImageType;
const unsigned int SpaceDimension = ImageDimension;
const unsigned int SplineOrder = 3;
typedef double CoordinateRepType;
typedef itk::BSplineDeformableTransform<
CoordinateRepType,
SpaceDimension,
SplineOrder > TransformType;
typedef itk::RegularStepGradientDescentOptimizer OptimizerType;
typedef itk::MattesMutualInformationImageToImageMetric<
FixedImageType,
MovingImageType > MetricType;
typedef itk:: LinearInterpolateImageFunction<
MovingImageType,
double > InterpolatorType;
typedef itk::ImageRegistrationMethod<
FixedImageType,
MovingImageType > RegistrationType;
MetricType::Pointer metric = MetricType::New();
OptimizerType::Pointer optimizer = OptimizerType::New();
InterpolatorType::Pointer interpolator = InterpolatorType::New();
RegistrationType::Pointer registration = RegistrationType::New();
registration->SetMetric( metric );
registration->SetOptimizer( optimizer );
registration->SetInterpolator( interpolator );
TransformType::Pointer transform = TransformType::New();
registration->SetTransform( transform );
//
// In general, you must first solve an Affine registration between
// the images before attempting to solve a deformable registration.
// If you have solve an affine transform, it can be loaded into the
// BSplineDeformableTransform as a "bulk" transform that will be
// pre-composed with the deformation computed by the BSpline.
// The following code loads one of such initial transforms if they
// are available.
//
typedef itk::TransformFileReader TransformReaderType;
typedef itk::AffineTransform<double, 3> AffineTransformType;
TransformReaderType::Pointer transformReader = TransformReaderType::New();
if( argc > 11 )
{
std::cout << "Loading Transform: " << argv[11] << std::endl;
transformReader->SetFileName( argv[11] );
transformReader->Update();
typedef TransformReaderType::TransformListType * TransformListType;
TransformListType transforms = transformReader->GetTransformList();
TransformReaderType::TransformListType::const_iterator tit = transforms->begin();
if( !strcmp((*tit)->GetNameOfClass(),"AffineTransform") )
{
AffineTransformType::Pointer affine_read =
static_cast<AffineTransformType*>((*tit).GetPointer());
AffineTransformType::Pointer affine_transform =
dynamic_cast< AffineTransformType * >( affine_read.GetPointer() );
if( affine_transform )
{
transform->SetBulkTransform( affine_transform );
}
}
else
{
std::cerr << "Bulk transform wasn't an affine transform." << std::endl;
return EXIT_FAILURE;
}
}
typedef itk::ImageFileReader< FixedImageType > FixedImageReaderType;
typedef itk::ImageFileReader< MovingImageType > MovingImageReaderType;
FixedImageReaderType::Pointer fixedImageReader = FixedImageReaderType::New();
MovingImageReaderType::Pointer movingImageReader = MovingImageReaderType::New();
fixedImageReader->SetFileName( argv[1] );
movingImageReader->SetFileName( argv[2] );
FixedImageType::ConstPointer fixedImage = fixedImageReader->GetOutput();
registration->SetFixedImage( fixedImage );
registration->SetMovingImage( movingImageReader->GetOutput() );
fixedImageReader->Update();
FixedImageType::RegionType fixedRegion = fixedImage->GetBufferedRegion();
registration->SetFixedImageRegion( fixedRegion );
unsigned int numberOfGridNodesInOneDimension = 5;
if( argc > 10 )
{
numberOfGridNodesInOneDimension = atoi( argv[10] );
}
typedef TransformType::RegionType RegionType;
RegionType bsplineRegion;
RegionType::SizeType gridSizeOnImage;
RegionType::SizeType gridBorderSize;
RegionType::SizeType totalGridSize;
gridSizeOnImage.Fill( numberOfGridNodesInOneDimension );
gridBorderSize.Fill( SplineOrder ); // Border for spline order = 3 ( 1 lower, 2 upper )
totalGridSize = gridSizeOnImage + gridBorderSize;
bsplineRegion.SetSize( totalGridSize );
typedef TransformType::SpacingType SpacingType;
SpacingType spacing = fixedImage->GetSpacing();
typedef TransformType::OriginType OriginType;
OriginType origin = fixedImage->GetOrigin();
FixedImageType::SizeType fixedImageSize = fixedRegion.GetSize();
for(unsigned int r=0; r<ImageDimension; r++)
{
spacing[r] *= static_cast<double>(fixedImageSize[r] - 1) /
static_cast<double>(gridSizeOnImage[r] - 1);
}
FixedImageType::DirectionType gridDirection = fixedImage->GetDirection();
SpacingType gridOriginOffset = gridDirection * spacing;
OriginType gridOrigin = origin - gridOriginOffset;
transform->SetGridSpacing( spacing );
transform->SetGridOrigin( gridOrigin );
transform->SetGridRegion( bsplineRegion );
transform->SetGridDirection( gridDirection );
typedef TransformType::ParametersType ParametersType;
const unsigned int numberOfParameters =
transform->GetNumberOfParameters();
ParametersType parameters( numberOfParameters );
parameters.Fill( 0.0 );
transform->SetParameters( parameters );
registration->SetInitialTransformParameters( transform->GetParameters() );
// Software Guide : EndCodeSnippet
// Software Guide : BeginLatex
//
// Next we set the parameters of the RegularStepGradientDescentOptimizer object.
//
// Software Guide : EndLatex
// Software Guide : BeginCodeSnippet
optimizer->SetMaximumStepLength( 10.0 );
optimizer->SetMinimumStepLength( 0.01 );
optimizer->SetRelaxationFactor( 0.7 );
optimizer->SetNumberOfIterations( 50 );
// Software Guide : EndCodeSnippet
// Optionally, get the step length from the command line arguments
if( argc > 12 )
{
optimizer->SetMaximumStepLength( atof( argv[12] ) );
}
// Optionally, get the number of iterations from the command line arguments
if( argc > 13 )
{
optimizer->SetNumberOfIterations( atoi( argv[13] ) );
}
// Create the Command observer and register it with the optimizer.
//
CommandIterationUpdate::Pointer observer = CommandIterationUpdate::New();
optimizer->AddObserver( itk::IterationEvent(), observer );
metric->SetNumberOfHistogramBins( 50 );
const unsigned int numberOfSamples =
static_cast<unsigned int>( fixedRegion.GetNumberOfPixels() * 20.0 / 100.0 );
metric->SetNumberOfSpatialSamples( numberOfSamples );
metric->ReinitializeSeed( 76926294 );
if( argc > 7 )
{
// Define whether to calculate the metric derivative by explicitly
// computing the derivatives of the joint PDF with respect to the Transform
// parameters, or doing it by progressively accumulating contributions from
// each bin in the joint PDF.
metric->SetUseExplicitPDFDerivatives( atoi( argv[7] ) );
}
if( argc > 8 )
{
// Define whether to cache the BSpline weights and indexes corresponding to
// each one of the samples used to compute the metric. Enabling caching will
// make the algorithm run faster but it will have a cost on the amount of memory
// that needs to be allocated. This option is only relevant when using the
// BSplineDeformableTransform.
metric->SetUseCachingOfBSplineWeights( atoi( argv[8] ) );
}
// Add time and memory probes
itkProbesCreate();
std::cout << std::endl << "Starting Registration" << std::endl;
try
{
itkProbesStart( "Registration" );
registration->StartRegistration();
itkProbesStop( "Registration" );
std::cout << "Optimizer stop condition = "
<< registration->GetOptimizer()->GetStopConditionDescription()
<< std::endl;
}
catch( itk::ExceptionObject & err )
{
std::cerr << "ExceptionObject caught !" << std::endl;
std::cerr << err << std::endl;
return EXIT_FAILURE;
}
OptimizerType::ParametersType finalParameters =
registration->GetLastTransformParameters();
// Report the time and memory taken by the registration
itkProbesReport( std::cout );
transform->SetParameters( finalParameters );
typedef itk::ResampleImageFilter<
MovingImageType,
FixedImageType > ResampleFilterType;
ResampleFilterType::Pointer resample = ResampleFilterType::New();
resample->SetTransform( transform );
resample->SetInput( movingImageReader->GetOutput() );
resample->SetSize( fixedImage->GetLargestPossibleRegion().GetSize() );
resample->SetOutputOrigin( fixedImage->GetOrigin() );
resample->SetOutputSpacing( fixedImage->GetSpacing() );
resample->SetOutputDirection( fixedImage->GetDirection() );
// This value is set to zero in order to make easier to perform
// regression testing in this example. However, for didactic
// exercise it will be better to set it to a medium gray value
// such as 100 or 128.
resample->SetDefaultPixelValue( 0 );
typedef signed short OutputPixelType;
typedef itk::Image< OutputPixelType, ImageDimension > OutputImageType;
typedef itk::CastImageFilter<
FixedImageType,
OutputImageType > CastFilterType;
typedef itk::ImageFileWriter< OutputImageType > WriterType;
WriterType::Pointer writer = WriterType::New();
CastFilterType::Pointer caster = CastFilterType::New();
writer->SetFileName( argv[3] );
caster->SetInput( resample->GetOutput() );
writer->SetInput( caster->GetOutput() );
try
{
writer->Update();
}
catch( itk::ExceptionObject & err )
{
std::cerr << "ExceptionObject caught !" << std::endl;
std::cerr << err << std::endl;
return EXIT_FAILURE;
}
typedef itk::SquaredDifferenceImageFilter<
FixedImageType,
FixedImageType,
OutputImageType > DifferenceFilterType;
DifferenceFilterType::Pointer difference = DifferenceFilterType::New();
WriterType::Pointer writer2 = WriterType::New();
writer2->SetInput( difference->GetOutput() );
// Compute the difference image between the
// fixed and resampled moving image.
if( argc > 4 )
{
difference->SetInput1( fixedImageReader->GetOutput() );
difference->SetInput2( resample->GetOutput() );
writer2->SetFileName( argv[4] );
try
{
writer2->Update();
}
catch( itk::ExceptionObject & err )
{
std::cerr << "ExceptionObject caught !" << std::endl;
std::cerr << err << std::endl;
return EXIT_FAILURE;
}
}
// Compute the difference image between the
// fixed and moving image before registration.
if( argc > 5 )
{
writer2->SetFileName( argv[5] );
difference->SetInput1( fixedImageReader->GetOutput() );
difference->SetInput2( movingImageReader->GetOutput() );
try
{
writer2->Update();
}
catch( itk::ExceptionObject & err )
{
std::cerr << "ExceptionObject caught !" << std::endl;
std::cerr << err << std::endl;
return EXIT_FAILURE;
}
}
// Generate the explicit deformation field resulting from
// the registration.
if( argc > 6 )
{
typedef itk::Vector< float, ImageDimension > VectorType;
typedef itk::Image< VectorType, ImageDimension > DeformationFieldType;
DeformationFieldType::Pointer field = DeformationFieldType::New();
field->SetRegions( fixedRegion );
field->SetOrigin( fixedImage->GetOrigin() );
field->SetSpacing( fixedImage->GetSpacing() );
field->SetDirection( fixedImage->GetDirection() );
field->Allocate();
typedef itk::ImageRegionIterator< DeformationFieldType > FieldIterator;
FieldIterator fi( field, fixedRegion );
fi.GoToBegin();
TransformType::InputPointType fixedPoint;
TransformType::OutputPointType movingPoint;
DeformationFieldType::IndexType index;
VectorType displacement;
while( ! fi.IsAtEnd() )
{
index = fi.GetIndex();
field->TransformIndexToPhysicalPoint( index, fixedPoint );
movingPoint = transform->TransformPoint( fixedPoint );
displacement = movingPoint - fixedPoint;
fi.Set( displacement );
++fi;
}
typedef itk::ImageFileWriter< DeformationFieldType > FieldWriterType;
FieldWriterType::Pointer fieldWriter = FieldWriterType::New();
fieldWriter->SetInput( field );
fieldWriter->SetFileName( argv[6] );
try
{
fieldWriter->Update();
}
catch( itk::ExceptionObject & excp )
{
std::cerr << "Exception thrown " << std::endl;
std::cerr << excp << std::endl;
return EXIT_FAILURE;
}
}
// Optionally, save the transform parameters in a file
if( argc > 9 )
{
std::ofstream parametersFile;
parametersFile.open( argv[9] );
parametersFile << finalParameters << std::endl;
parametersFile.close();
}
return EXIT_SUCCESS;
}
#undef itkProbesCreate
#undef itkProbesStart
#undef itkProbesStop
#undef itkProbesReport
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