File: itkLabelGeometryImageFilter.h

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/*=========================================================================

  Program:   Insight Segmentation & Registration Toolkit
  Module:    itkLabelGeometryImageFilter.h
  Language:  C++
  Date:      $Date$
  Version:   $Revision$

  Copyright (c) Insight Software Consortium. All rights reserved.
  See ITKCopyright.txt or http://www.itk.org/HTML/Copyright.htm for details.

     This software is distributed WITHOUT ANY WARRANTY; without even 
     the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR 
     PURPOSE.  See the above copyright notices for more information.

=========================================================================*/
#ifndef __itkLabelGeometryImageFilter_h
#define __itkLabelGeometryImageFilter_h

#include "itkImageToImageFilter.h"
#include "itkNumericTraits.h"
#include "itkArray.h"
#include "itkSimpleDataObjectDecorator.h"
#include "itk_hash_map.h"
#include "itkFastMutexLock.h"
#include <vector>
#include <vnl/algo/vnl_symmetric_eigensystem.h>
#include <vnl/vnl_det.h>
#include <vnl/vnl_math.h>
#include <vcl_cmath.h>


namespace itk {

/** \class LabelGeometryImageFilter 
 * \brief Given a label map and an optional intensity image, compute
 * geometric features.
 *
 * This filter enables the measurement of geometric features of all objects in
 * a labeled ND volume. This labeled volume can represent, for instance, a
 * medical image segmented into different anatomical structures or a microscope
 * image segmented into individual cells. This filter is closely related to the
 * itkLabelStatisticsImageFilter, which measures statistics of image regions
 * defined by a labeled mask such as min, max, and mean intensity, intensity
 * standard deviation, and bounding boxes. This filter, however, measures the
 * geometry of the labeled regions themselves.  
 *
 * It calculates features similar to the regionprops command of Matlab.  The
 * set of measurements that it enables include: volume, centroid, eigenvalues,
 * eigenvectors, axes lenghts, eccentricity, elongation, orientation, bounding
 * box, oriented bounding box, and rotation matrix.  These features are based
 * solely on the labeled mask itself.  It also calculates integrated intensity
 * and weighted centroid, which are measured on an intensity image under the
 * labeled mask. These features represent the set of currently calculated
 * features, but the framework of the filter is designed so that it can be
 * easily expanded to measure a wide variety of other features. 
 *
 *  \authors Dirk Padfield and James Miller.
 *
 *  This work is part of the National Alliance for Medical Image
 *  Computing (NAMIC), funded by the National Institutes of Health
 *  through the NIH Roadmap for Medical Research, Grant U54 EB005149.
 *  Information on the National Centers for Biomedical Computing
 *  can be obtained from http://nihroadmap.nih.gov/bioinformatics.
 *
 *  This filter was contributed in the Insight Journal paper:
 *  "A Label Geometry Image Filter for Multiple Object Measurement"
 *  by Padfield D., Miller J
 *  http://www.insight-journal.org/browse/publication/301
 *  http://hdl.handle.net/1926/1493
 * 
 */
template<class TLabelImage, class TIntensityImage = TLabelImage>
class ITK_EXPORT LabelGeometryImageFilter : 
    public ImageToImageFilter<TLabelImage, TIntensityImage>
{
public:
  /** Standard Self typedef */
  typedef LabelGeometryImageFilter                          Self;
  typedef ImageToImageFilter<TLabelImage,TIntensityImage>   Superclass;
  typedef SmartPointer<Self>                                Pointer;
  typedef SmartPointer<const Self>                          ConstPointer;
  
  /** Method for creation through the object factory. */
  itkNewMacro(Self);  

  /** Runtime information support. */
  itkTypeMacro(LabelGeometryImageFilter, ImageToImageFilter);
  
  /** Image related typedefs. */
  typedef TIntensityImage                         IntensityImageType;
  typedef typename TIntensityImage::Pointer       InputImagePointer;
  typedef typename TIntensityImage::RegionType    RegionType;
  typedef typename TIntensityImage::SizeType      SizeType;
  typedef typename TIntensityImage::IndexType     IndexType;
  typedef typename TIntensityImage::PixelType     PixelType;

  /** Label image related typedefs. */
  typedef TLabelImage                             LabelImageType;
  typedef typename TLabelImage::Pointer           LabelImagePointer;
  typedef typename TLabelImage::RegionType        LabelRegionType;
  typedef typename TLabelImage::SizeType          LabelSizeType;
  typedef typename TLabelImage::IndexType         LabelIndexType;
  typedef typename TLabelImage::PixelType         LabelPixelType;
  typedef typename TLabelImage::PointType         LabelPointType;

  /** Image related typedefs. */
  itkStaticConstMacro(ImageDimension, unsigned int,
                      TLabelImage::ImageDimension );

  /** Type to use for computations. */
  typedef typename NumericTraits<PixelType>::RealType RealType;

  /** Smart Pointer type to a DataObject. */
  typedef typename DataObject::Pointer DataObjectPointer;

  /** Type of DataObjects used for scalar outputs */
  typedef SimpleDataObjectDecorator<RealType> RealObjectType;

  /** Bounding Box-related typedefs */
  typedef itk::FixedArray<typename LabelIndexType::IndexValueType,itkGetStaticConstMacro(ImageDimension)*2> BoundingBoxType;
  typedef itk::FixedArray< float,itkGetStaticConstMacro(ImageDimension)*2> BoundingBoxFloatType;

  //typedef itk::FixedArray< LabelPointType,vcl_pow(2.0,itkGetStaticConstMacro(ImageDimension))> BoundingBoxVerticesType;
  typedef std::vector< LabelPointType > BoundingBoxVerticesType;

  /** Axes Length-related typedefs */
  typedef itk::FixedArray<RealType,itkGetStaticConstMacro(ImageDimension)> AxesLengthType;

  /** Index array typedefs */
  typedef itk::FixedArray< typename LabelIndexType::IndexValueType, itkGetStaticConstMacro(ImageDimension) > IndexArrayType;

  /** vector of labels */
  typedef std::vector< LabelPixelType > LabelsType;

  /** vector of indices */
  typedef std::vector< LabelIndexType > LabelIndicesType;

  /** Vector type */
  typedef std::vector< double > VectorType;

  /** Matrix type */
  typedef vnl_matrix<double> MatrixType;

  /** \class LabelGeometry
   * \brief Geometry stored per label
   */
  class LabelGeometry
    {
    public:
      // default constructor
      LabelGeometry()
      {
        // initialized to the default values
      this->m_Label = 0;
      this->m_Sum = NumericTraits<RealType>::Zero;

      const unsigned int imageDimension = itkGetStaticConstMacro(ImageDimension);

      //m_BoundingBox.resize(imageDimension*2);
      for (unsigned int i = 0; i < imageDimension * 2; i += 2)
        {
        m_BoundingBox[i] = NumericTraits<ITK_TYPENAME IndexType::IndexValueType>::max();
        m_BoundingBox[i+1] = NumericTraits<ITK_TYPENAME IndexType::IndexValueType>::NonpositiveMin();
        }
        
      m_BoundingBoxVolume = 0;
      m_BoundingBoxSize.Fill(0);
      m_PixelIndices.clear();
      m_Centroid.Fill( 0 );
      m_WeightedCentroid.Fill( 0 );
      m_ZeroOrderMoment = 0;
      m_FirstOrderRawMoments.Fill( 0 );
      m_FirstOrderWeightedRawMoments.Fill( 0 );
      m_Eigenvalues.resize(ImageDimension);
      m_Eigenvalues.clear();
      m_Eigenvectors.set_size(ImageDimension,ImageDimension);
      m_Eigenvectors.fill(0);
      m_AxesLength.Fill( 0 );
      m_Eccentricity = 1;
      m_Elongation = 1;
      m_Orientation = 0;
      LabelPointType emptyPoint;
      emptyPoint.Fill( 0 );
      unsigned int numberOfVertices = (unsigned int)vcl_pow( (double)2, (int)ImageDimension );
      m_OrientedBoundingBoxVertices.resize(numberOfVertices,emptyPoint);
      m_OrientedBoundingBoxVolume = 0;
      m_OrientedBoundingBoxSize.Fill(0);
      m_OrientedLabelImage = LabelImageType::New();
      m_OrientedIntensityImage = IntensityImageType::New();
      m_OrientedBoundingBoxOrigin.Fill( 0 );
      m_RotationMatrix.set_size(ImageDimension,ImageDimension);
      m_RotationMatrix.fill( 0.0 );
      
      m_SecondOrderRawMoments.set_size(ImageDimension,ImageDimension);
      m_SecondOrderCentralMoments.set_size(ImageDimension,ImageDimension);
      for( unsigned int i = 0; i < ImageDimension; i++ )
        {
        for( unsigned int j = 0; j < ImageDimension; j++ )
          {
          m_SecondOrderRawMoments(i,j) = 0;
          m_SecondOrderCentralMoments(i,j) = 0;
          }
        }
      }

    LabelPixelType m_Label;
    RealType m_Sum;
    LabelPointType m_Centroid;
    LabelPointType m_WeightedCentroid;
    unsigned long m_ZeroOrderMoment;
    IndexArrayType m_FirstOrderRawMoments;
    IndexArrayType m_FirstOrderWeightedRawMoments;
    unsigned long  m_FirstOrderRawCrossMoment;
    RealType  m_FirstOrderCentralCrossMoment;
    MatrixType m_SecondOrderRawMoments;
    MatrixType m_SecondOrderCentralMoments;
    VectorType m_Eigenvalues;
    MatrixType m_Eigenvectors;
    FixedArray<float,itkGetStaticConstMacro(ImageDimension)> m_AxesLength;
    RealType m_Eccentricity;
    RealType m_Elongation;
    RealType m_Orientation;
    BoundingBoxType m_BoundingBox;
    LabelSizeType m_BoundingBoxSize;
    RealType m_BoundingBoxVolume;
    LabelIndicesType m_PixelIndices;
    BoundingBoxVerticesType m_OrientedBoundingBoxVertices;
    RealType m_OrientedBoundingBoxVolume;
    LabelPointType m_OrientedBoundingBoxSize;
    typename LabelImageType::Pointer m_OrientedLabelImage;
    typename IntensityImageType::Pointer m_OrientedIntensityImage;
    MatrixType m_RotationMatrix;
    LabelPointType m_OrientedBoundingBoxOrigin;
  };
  
  /** Type of the map used to store data per label */
  // Map from the label to the class storing all of the geometry information.
  typedef itk::hash_map<LabelPixelType, LabelGeometry> MapType;
  typedef typename itk::hash_map<LabelPixelType, LabelGeometry>::iterator MapIterator;
  typedef typename itk::hash_map<LabelPixelType, LabelGeometry>::const_iterator MapConstIterator;
  
  // Macros for enabling the calculation of additional features.
  itkGetMacro(CalculatePixelIndices, bool);
  itkBooleanMacro(CalculatePixelIndices);
  void SetCalculatePixelIndices( const bool value )
    {
    // CalculateOrientedBoundingBox, CalculateOrientedLabelImage, and
    // CalculateOrientedIntensityImage all need CalculatePixelIndices to be turned
    // on if they are turned on.  So, CalculatePixelIndices cannot be
    // turned off if any of these flags are turned on.
    if( value == false )
      {
      if( (this->m_CalculateOrientedBoundingBox == true) ||
          (this->m_CalculateOrientedLabelRegions == true) ||
          (this->m_CalculateOrientedIntensityRegions == true) )
        {
        // We cannot change the value, so return.
        return;
        }
      }
    
    if ( this->m_CalculatePixelIndices != value )
      {
      this->m_CalculatePixelIndices = value;
      this->Modified();
      }
    }
  
  itkGetMacro(CalculateOrientedBoundingBox, bool);
  itkBooleanMacro(CalculateOrientedBoundingBox);
  void SetCalculateOrientedBoundingBox( const bool value )
    {

    if (this->m_CalculateOrientedBoundingBox != value)
      {
      this->m_CalculateOrientedBoundingBox = value;
      this->Modified();
      }

    // CalculateOrientedBoundingBox needs
    // CalculatePixelIndices to be turned on.
    if( value == true )
      {
      this->SetCalculatePixelIndices( true );
      }

    }

  itkGetMacro(CalculateOrientedLabelRegions, bool);
  itkBooleanMacro(CalculateOrientedLabelRegions);
  void SetCalculateOrientedLabelRegions( const bool value )
    {
    if (this->m_CalculateOrientedLabelRegions != value)
      {
      this->m_CalculateOrientedLabelRegions = value;
      this->Modified();

      // CalculateOrientedLabelImage needs
      // CalculateOrientedBoundingBox to be turned on.
      if( value == true )
        {
        SetCalculateOrientedBoundingBox( true );
        }
      }
    }

  itkGetMacro(CalculateOrientedIntensityRegions, bool);
  itkBooleanMacro(CalculateOrientedIntensityRegions);
  void SetCalculateOrientedIntensityRegions( const bool value )
    {
    if (this->m_CalculateOrientedIntensityRegions != value)
      {
      this->m_CalculateOrientedIntensityRegions = value;
      this->Modified();

      // CalculateOrientedIntensityImage needs
      // CalculateOrientedBoundingBox to be turned on.
      if( value == true )
        {
        this->SetCalculateOrientedBoundingBox( true );
        }
      }
    }

  /** Set the intensity image */
  void SetIntensityInput(const TIntensityImage *input )
    {
    // Process object is not const-correct so the const casting is required.
    this->SetNthInput(1, const_cast<TIntensityImage *>(input) );
    }

  /** Get the label image */
  const TIntensityImage * GetIntensityInput() const
    {
    return static_cast<TIntensityImage*>(const_cast<DataObject *>(this->ProcessObject::GetInput(1)));
    }

  /** Does the specified label exist? Can only be called after 
   * a call to Update(). */
  bool HasLabel(LabelPixelType label) const
    {
    return m_LabelGeometryMapper.find(label) != m_LabelGeometryMapper.end();
    }

  /** Get the number of labels used */
  unsigned long GetNumberOfObjects() const
    {
    return m_LabelGeometryMapper.size();
    }
  unsigned long GetNumberOfLabels() const
    {
    return this->GetNumberOfObjects();
    }

  /** Get the labels that are in the image. */
  std::vector< LabelPixelType > GetLabels() const
    {
    return m_AllLabels;
    }

  /** Return the all pixel indices for a label. */
  LabelIndicesType GetPixelIndices( LabelPixelType label) const;

  /** Return the number of pixels for a label.  This is the same as
   * the volume and the zero order moment */
  unsigned long GetVolume(LabelPixelType label) const;

  /** Return the number of pixels for all labels. */
  //std::vector<unsigned long> GetAllCounts() const;

  /** Return the computed integrated pixel intensity for a label. */
  RealType GetIntegratedIntensity(LabelPixelType label) const;

  /** Return the unweighted centroid for a label. */
  LabelPointType GetCentroid( LabelPixelType label) const;

  /** Return the weighted centroid for a label. */
  LabelPointType GetWeightedCentroid( LabelPixelType label) const;

  /** Return the eigenvalues as a vector. */
  VectorType GetEigenvalues (LabelPixelType label) const;

  /** Return the eigenvectors as a matrix. */
  MatrixType GetEigenvectors (LabelPixelType label) const;

  /** Return the axes length for a label. */
  AxesLengthType GetAxesLength( LabelPixelType label) const;

  /** Return the minor axis length for a label.  This is a convenience
   * class that returns the shortest length from GetAxesLength. */
  RealType GetMinorAxisLength( LabelPixelType label) const;

  /** Return the major axis length for a label.  This is a convenience
   * class that returns the longest length from GetAxesLength. */
  RealType GetMajorAxisLength( LabelPixelType label) const;

  /** Return the eccentricity for a label. */
  RealType GetEccentricity( LabelPixelType label) const;

  /** Return the elongation for a label.  This is defined as the
   * length of the major axis divided by the length of the minor axis. */
  RealType GetElongation( LabelPixelType label) const;

  /** Return the orientation for a label defined in radians. */
  RealType GetOrientation( LabelPixelType label) const;

  /** Return the computed bounding box for a label. 
   * This is organized in min/max pairs as [min(X), max(X), min(Y),
   * max(Y), min(Z), max(Z),...]  */
  BoundingBoxType GetBoundingBox(LabelPixelType label) const;

  /** Return the volume of the bounding box. */
  RealType GetBoundingBoxVolume(LabelPixelType label) const;
  
  /** Return the size of the bounding box. */
  LabelSizeType GetBoundingBoxSize(LabelPixelType label) const;

  /** Return the oriented bounding box vertices.  The order of the
   * vertices corresponds with binary counting, where min is zero and
   * max is one.  For example, in 2D, binary counting will give
   * [0,0],[0,1],[1,0],[1,1], which corresponds to
   * [minX,minY],[minX,maxY],[maxX,minY],[maxX,maxY]. Each
   * vertex is defined as an ND point.   */
  BoundingBoxVerticesType GetOrientedBoundingBoxVertices(LabelPixelType label) const;

  /** Return the volume of the oriented bounding box. */
  RealType GetOrientedBoundingBoxVolume(LabelPixelType label) const;

  /** Return the size of the oriented bounding box. */
  LabelPointType GetOrientedBoundingBoxSize(LabelPixelType label) const;

  /** Return the origin of the oriented bounding box. */
  LabelPointType GetOrientedBoundingBoxOrigin(LabelPixelType label) const;

  /** Return the rotation matrix defined by the
   * eigenvalues/eigenvectors. */
  MatrixType GetRotationMatrix(LabelPixelType label) const;

  /** Return the region defined by the bounding box. */
  RegionType GetRegion(LabelPixelType label) const;

  /** Return the label region defined by the oriented bounding box. */
  TLabelImage *GetOrientedLabelImage( LabelPixelType label) const;

  /** Return the intensity region defined by the oriented bounding
   * box. */
  TIntensityImage * GetOrientedIntensityImage( LabelPixelType label) const;


#ifdef ITK_USE_CONCEPT_CHECKING
  /** Begin concept checking */
  itkConceptMacro(InputHasNumericTraitsCheck,
                  (Concept::HasNumericTraits<PixelType>));
  /** End concept checking */
#endif

protected:
  LabelGeometryImageFilter();
  ~LabelGeometryImageFilter(){};
  void PrintSelf(std::ostream& os, Indent indent) const;

  void GenerateData();

private:
  LabelGeometryImageFilter(const Self&); //purposely not implemented
  void operator=(const Self&); //purposely not implemented

  bool CalculateOrientedBoundingBoxVertices(vnl_symmetric_eigensystem<double> eig, LabelGeometry & m_LabelGeometry);

  bool m_CalculatePixelIndices;
  bool m_CalculateOrientedBoundingBox;
  bool m_CalculateOrientedLabelRegions;
  bool m_CalculateOrientedIntensityRegions;

  MapType         m_LabelGeometryMapper;
  LabelGeometry   m_LabelGeometry;
  LabelsType      m_AllLabels;

  SimpleFastMutexLock m_Mutex;

}; // end of class

template<class TLabelImage, class TIntensityImage>
typename LabelGeometryImageFilter<TLabelImage,TIntensityImage>::MatrixType CalculateRotationMatrix(vnl_symmetric_eigensystem<double> eig);

template<class TLabelImage, class TIntensityImage, class TGenericImage>
bool CalculateOrientedImage(
  LabelGeometryImageFilter<TLabelImage, TIntensityImage>  *filter,
  vnl_symmetric_eigensystem<double> eig,
  typename LabelGeometryImageFilter<TLabelImage,TIntensityImage>::LabelGeometry & labelGeometry,
  bool useLabelImage = true);

} // end namespace itk
  
#ifndef ITK_MANUAL_INSTANTIATION
#include "itkLabelGeometryImageFilter.txx"
#endif

#endif