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"""
Shared pytest configuration and fixtures for Kalign Python tests.
"""
import pytest
import tempfile
import os
from pathlib import Path
from typing import List, Dict, Any
# Rich table support for benchmarks
try:
from rich.console import Console
from rich.table import Table
from rich.text import Text
RICH_AVAILABLE = True
except ImportError:
RICH_AVAILABLE = False
# Test data constants
DNA_SEQUENCES_SIMPLE = ["ATCGATCG", "ATCGTCG", "ATCGATCG"]
DNA_SEQUENCES_WITH_GAPS = [
"ATCGATCGATCG",
"ATCGTCGATCG",
"ATCGATCATCG",
"ATCGATCGAGATCG",
]
RNA_SEQUENCES_SIMPLE = ["AUCGAUCG", "AUCGUCG", "AUCGAUCG"]
PROTEIN_SEQUENCES_SIMPLE = ["MKTAYIAK", "MKTAYK", "MKTAYIAK"]
PROTEIN_SEQUENCES_COMPLEX = [
"MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWUAIFRRVVSAEFQRQPVHQSYLNTVLGSQGKL",
"MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWUAIFRRVVSAEFQRQPVHQSYLNTVLGSQGKL",
"MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWUAIFRRVVSAEFQRQPVHQSYLNTVLGSQGKL",
]
INVALID_DNA_SEQUENCES = [
"ATCG123", # Contains numbers
"ATCGXYZ", # Invalid characters
"ATCG@#$", # Special characters
]
MIXED_CASE_SEQUENCES = ["AtCgAtCg", "atcgatcg", "ATCGATCG"]
@pytest.fixture
def dna_simple():
"""Simple DNA sequences for basic testing."""
return DNA_SEQUENCES_SIMPLE.copy()
@pytest.fixture
def dna_with_gaps():
"""DNA sequences that will likely produce gaps."""
return DNA_SEQUENCES_WITH_GAPS.copy()
@pytest.fixture
def rna_simple():
"""Simple RNA sequences for basic testing."""
return RNA_SEQUENCES_SIMPLE.copy()
@pytest.fixture
def protein_simple():
"""Simple protein sequences for basic testing."""
return PROTEIN_SEQUENCES_SIMPLE.copy()
@pytest.fixture
def protein_complex():
"""Complex protein sequences for advanced testing."""
return PROTEIN_SEQUENCES_COMPLEX.copy()
@pytest.fixture
def invalid_dna():
"""Invalid DNA sequences for error testing."""
return INVALID_DNA_SEQUENCES.copy()
@pytest.fixture
def mixed_case():
"""Mixed case sequences for case handling testing."""
return MIXED_CASE_SEQUENCES.copy()
@pytest.fixture
def temp_dir():
"""Create a temporary directory for file operations."""
with tempfile.TemporaryDirectory() as tmpdir:
yield Path(tmpdir)
@pytest.fixture
def sample_fasta_file(temp_dir):
"""Create a sample FASTA file for testing."""
fasta_content = """>seq1
ATCGATCGATCG
>seq2
ATCGTCGATCG
>seq3
ATCGATCATCG
"""
fasta_file = temp_dir / "sample.fasta"
fasta_file.write_text(fasta_content)
return str(fasta_file)
@pytest.fixture
def sample_protein_fasta_file(temp_dir):
"""Create a sample protein FASTA file for testing."""
fasta_content = """>protein1
MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVY
>protein2
MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLH
>protein3
MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRL
"""
fasta_file = temp_dir / "proteins.fasta"
fasta_file.write_text(fasta_content)
return str(fasta_file)
@pytest.fixture
def invalid_fasta_file(temp_dir):
"""Create an invalid FASTA file for error testing."""
invalid_content = """This is not a valid FASTA file
It has no proper headers
And random content
"""
invalid_file = temp_dir / "invalid.fasta"
invalid_file.write_text(invalid_content)
return str(invalid_file)
@pytest.fixture
def nonexistent_file():
"""Return path to a file that doesn't exist."""
return "/path/that/does/not/exist.fasta"
@pytest.fixture
def test_data_dir():
"""Get the test data directory path."""
return Path(__file__).parent / "test_data"
# Parametrize fixtures for common test scenarios
@pytest.fixture(
params=[
("dna", DNA_SEQUENCES_SIMPLE),
("rna", RNA_SEQUENCES_SIMPLE),
("protein", PROTEIN_SEQUENCES_SIMPLE),
]
)
def sequence_type_data(request):
"""Parametrized fixture providing different sequence types."""
seq_type, sequences = request.param
return seq_type, sequences.copy()
@pytest.fixture(params=[1, 2, 4])
def thread_count(request):
"""Parametrized fixture for testing different thread counts."""
return request.param
@pytest.fixture(
params=[
("auto", None),
("dna", "dna"),
("rna", "rna"),
("protein", "protein"),
("divergent", "divergent"),
("internal", "internal"),
]
)
def sequence_type_spec(request):
"""Parametrized fixture for testing sequence type specifications."""
return request.param
# Pytest configuration
def pytest_configure(config):
"""Configure pytest with custom markers."""
config.addinivalue_line("markers", "slow: mark test as slow running")
config.addinivalue_line("markers", "integration: mark test as integration test")
config.addinivalue_line("markers", "performance: mark test as performance test")
config.addinivalue_line("markers", "file_io: mark test as requiring file I/O")
def pytest_collection_modifyitems(config, items):
"""Add markers to tests based on their names."""
for item in items:
# Mark slow tests
if "slow" in item.nodeid or "large" in item.nodeid:
item.add_marker(pytest.mark.slow)
# Mark integration tests
if "integration" in item.nodeid:
item.add_marker(pytest.mark.integration)
# Mark performance tests
if "performance" in item.nodeid or "benchmark" in item.nodeid:
item.add_marker(pytest.mark.performance)
# Mark file I/O tests
if "file" in item.nodeid:
item.add_marker(pytest.mark.file_io)
# Helper functions for tests
def assert_valid_alignment(sequences: List[str], aligned: List[str]) -> None:
"""Assert that an alignment result is valid."""
# Same number of sequences
assert len(aligned) == len(sequences), "Number of sequences changed"
# All aligned sequences have same length
if aligned:
expected_length = len(aligned[0])
for i, seq in enumerate(aligned):
assert len(seq) == expected_length, f"Sequence {i} has different length"
# No empty sequences (unless input was empty)
for seq in aligned:
if any(
original for original in sequences if original
): # If any input was non-empty
assert seq, "Aligned sequence is empty"
def assert_alignment_preserves_characters(
original: List[str], aligned: List[str]
) -> None:
"""Assert that alignment preserves the original characters (just adds gaps)."""
for orig, align in zip(original, aligned):
# Remove gaps from aligned sequence
degapped = align.replace("-", "")
assert degapped == orig, f"Original sequence {orig} not preserved in {align}"
def calculate_identity(seq1: str, seq2: str) -> float:
"""Calculate sequence identity percentage between two sequences."""
if len(seq1) != len(seq2):
raise ValueError("Sequences must have same length")
matches = sum(1 for a, b in zip(seq1, seq2) if a == b and a != "-" and b != "-")
valid_positions = sum(1 for a, b in zip(seq1, seq2) if a != "-" and b != "-")
return (matches / valid_positions * 100) if valid_positions > 0 else 0.0
# Expected results for regression testing
EXPECTED_ALIGNMENTS = {
"dna_simple": {
"sequences": DNA_SEQUENCES_SIMPLE,
"expected_length": 8, # This might need adjustment after testing
"min_identity": 75.0, # Minimum expected identity percentage
},
"protein_simple": {
"sequences": PROTEIN_SEQUENCES_SIMPLE,
"expected_length": 8, # This might need adjustment after testing
"min_identity": 85.0, # Minimum expected identity percentage
},
}
@pytest.fixture
def expected_results():
"""Expected alignment results for regression testing."""
return EXPECTED_ALIGNMENTS.copy()
# Note: pytest_benchmark_update_json hook removed to avoid plugin validation errors
# when pytest-benchmark is not installed. If you need benchmark display functionality,
# install pytest-benchmark: pip install pytest-benchmark
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