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/*
This file is a part of KMC software distributed under GNU GPL 3 licence.
The homepage of the KMC project is http://sun.aei.polsl.pl/kmc
Authors: Marek Kokot
Version: 3.2.4
Date : 2024-02-09
*/
#ifndef _CONFIG_H
#define _CONFIG_H
#include "defs.h"
#include <string>
#include <vector>
#include <memory>
#include <cstring>
#include "kmer_file_header.h"
#include "percent_progress.h"
enum class CounterOpType { MIN, MAX, SUM, DIFF, FROM_DB1, FROM_DB2, NONE };
enum class OutputType { KMC1, KFF1 };
enum class KmerDBOpenMode { sequential, sorted, counters_only };
class CCounterBuilder
{
public:
static void build_counter(uint32& counter, uchar *&buffer, uint32 counter_bytes, uint32 counter_mask, bool little_endian)
{
if (counter_bytes == 0)
{
counter = 1;
return;
}
memcpy(&counter, buffer, sizeof(counter));
if (!little_endian)
counter = _bswap_uint32(counter);
counter &= counter_mask;
buffer += counter_bytes;
}
};
struct CDescBase
{
std::string file_src;
uint32 cutoff_min = 0; //0 means it is not set yet
uint64 cutoff_max = 0; //0 means it is not set yet
CDescBase(const std::string& file_src) :
file_src(file_src)
{
}
CDescBase() = default;
};
//************************************************************************************************************
// CInputDesc - description of a single input KMC database.
//************************************************************************************************************
struct CInputDesc : public CDescBase
{
uint32 threads = 0; //for kmc2 input
CInputDesc(const std::string& file_src) :
CDescBase(file_src)
{
}
CInputDesc() = default;
};
//************************************************************************************************************
// COutputDesc - description of a output KMC database.
//************************************************************************************************************
struct COutputDesc : public CDescBase
{
uint32 counter_max = 0; //0 means it is not set yet
uint64 counter_value = 0; //only for SET_COUNTER operation, 0 means not set yet
uint8_t encoding = 0b00011011; //for KFF writers
OutputType output_type = OutputType::KMC1;
COutputDesc(const std::string& file_src) :
CDescBase(file_src)
{
}
COutputDesc() = default;
};
struct CSimpleOutputDesc : public COutputDesc
{
enum class OpType { INTERSECT, UNION, KMERS_SUBTRACTION, COUNTERS_SUBTRACTION, REVERSE_KMERS_SUBTRACTION, REVERSE_COUNTERS_SUBTRACTION };
OpType op_type;
CounterOpType counter_op;
CSimpleOutputDesc(OpType op_type) :
op_type(op_type)
{
switch (op_type)
{
case OpType::INTERSECT:
counter_op = CounterOpType::MIN;
break;
case OpType::UNION:
counter_op = CounterOpType::SUM;
break;
case OpType::KMERS_SUBTRACTION: //irrelevant for KMERS_SUBTRACTION and REVERSE_KMERS_SUBTRACTION
case OpType::COUNTERS_SUBTRACTION:
case OpType::REVERSE_COUNTERS_SUBTRACTION:
case OpType::REVERSE_KMERS_SUBTRACTION:
counter_op = CounterOpType::DIFF;
break;
}
}
};
struct CTransformOutputDesc : public COutputDesc
{
enum class OpType { HISTOGRAM, DUMP, SORT, REDUCE, COMPACT, SET_COUNTS };
OpType op_type;
bool sorted_output = false; //only for dump operation, rest is sorted anyway (except histo which does not print k-mers at all)
CTransformOutputDesc(OpType op_type) :op_type(op_type)
{ }
};
struct CFilteringParams
{
enum class file_type { fasta, fastq };
enum class FilterMode {normal, trim, hard_mask};
uint32 n_readers;
uint32 n_filters;
int fastq_buffer_size;
int64 mem_part_pmm_fastq_reader;
int64 mem_tot_pmm_fastq_reader;
int64 mem_part_pmm_fastq_filter;
int64 mem_tot_pmm_fastq_filter;
uint32 kmer_len;
uint32 gzip_buffer_size = 64 << 20;
std::vector<std::string> input_srcs;
bool use_float_value = false;
uint32 n_min_kmers = 2;
uint32 n_max_kmers = 1000000000;
float f_min_kmers = 0.0f;
float f_max_kmers = 1.0f;
file_type input_file_type = file_type::fastq;
file_type output_file_type = file_type::fastq;
std::string output_src;
FilterMode filter_mode = FilterMode::normal;
};
struct CCheckParams
{
std::string kmer;
};
//************************************************************************************************************
// CConfig - configuration of current application run. Singleton class.
//************************************************************************************************************
class CConfig
{
public:
enum class Mode { UNDEFINED, COMPLEX, COMPARE, FILTER, SIMPLE_SET, TRANSFORM, INFO, CHECK };
uint32 avaiable_threads;
uint32 kmer_len = 0;
Mode mode = Mode::UNDEFINED;
bool verbose = false;
std::vector<CInputDesc> input_desc;
std::vector<CKmerFileHeader> headers;
COutputDesc output_desc; //complex only?
std::vector<CSimpleOutputDesc> simple_output_desc;
CFilteringParams filtering_params; //for filter operation only
CCheckParams check_params; // for check operation only
std::vector<CTransformOutputDesc> transform_output_desc;
CPercentProgress percent_progress;
static CConfig& GetInstance()
{
static CConfig config;
return config;
}
CConfig(const CConfig&) = delete;
CConfig& operator=(const CConfig&) = delete;
bool IsLittleEndian()
{
uint64 a = 0x0807060504030201;
return ((uchar*)&a)[0] == 1 && ((uchar*)&a)[1] == 2 && ((uchar*)&a)[2] == 3 && ((uchar*)&a)[3] == 4 && ((uchar*)&a)[5] == 6 && ((uchar*)&a)[7] == 8;
}
bool IsSeparateThreadForMainProcessingNeeded()
{
return mode == Mode::SIMPLE_SET || mode == Mode::COMPLEX || mode == Mode::COMPARE;
}
std::string GetOperationName()
{
switch (mode)
{
case CConfig::Mode::UNDEFINED:
return "";
case CConfig::Mode::COMPLEX:
return "complex";
case CConfig::Mode::COMPARE:
return "compare";
case CConfig::Mode::FILTER:
return "filter";
case CConfig::Mode::SIMPLE_SET:
return "simple";
case CConfig::Mode::TRANSFORM:
return "transform";
case CConfig::Mode::CHECK:
return "check";
default:
return "";
}
}
private:
CConfig() = default;
};
class CUsageDisplayer
{
protected:
std::string name;
bool is2ArgOper = false;
bool is1ArgOper = false;
CUsageDisplayer(const std::string& name) :name(name){}
void Display2ArgGeneral() const
{
std::cout << "The '" << name << "' is two arguments' operation. General syntax:\n"
<< " kmc_tools " << name << " <input1 [input1_params]> <input2 [input2_params]> <output [output_params]>\n"
<< " input1, input2 - paths to databases generated by KMC \n"
<< " output - path to output database\n"
<< " For each input there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " For output there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " -cs<value> - maximal value of a counter\n";
}
void Display1ArgGeneral(bool output_params) const
{
std::cout << " The '" << name << "' is one argument operation. General syntax:\n"
<< " kmc_tools " << name << " <input> [input_params] <output> "<< (output_params ? "[output_params]" : "") << "\n"
<< " input - path to database generated by KMC \n"
<< " For input there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n";
}
public:
virtual void Display() const = 0;
virtual ~CUsageDisplayer() {}
};
class CGeneralUsageDisplayer : public CUsageDisplayer
{
public:
CGeneralUsageDisplayer() :CUsageDisplayer("")
{}
void Display() const override
{
std::cout << "kmc_tools ver. " << KMC_VER << " (" << KMC_DATE << ")\n"
<< "Usage:\n kmc_tools [global parameters] <operation> [operation parameters]\n"
<< "Available operations:\n"
<< " transform - transforms single KMC's database\n"
<< " simple - performs set operation on two KMC's databases\n"
<< " complex - performs set operation on multiple KMC's databases\n"
<< " filter - filter out reads with too small number of k-mers\n"
<< " global parameters:\n"
<< " -t<value> - total number of threads (default: no. of CPU cores)\n"
<< " -v - enable verbose mode (shows some information) (default: false)\n"
<< " -hp - hide percentage progress (default: false)\n"
<< "Example:\n"
<< "kmc_tools simple db1 -ci3 db2 -ci5 -cx300 union db1_union_db2 -ci10\n"
<< "For detailed help of concrete operation type operation name without parameters:\n"
<< "kmc_tools simple\n";
}
};
class CSimpleOperationUsageDisplayer : public CUsageDisplayer
{
public:
CSimpleOperationUsageDisplayer() : CUsageDisplayer("simple"){}
void Display() const override
{
std::cout << "simple operation performs set operation on two input KMC's databases\n"
<< "General syntax:\n"
<< "kmc_tools simple <input1 [input1_params]> <input2 [input2_params]> <oper1 output1 [output_params1]> [<oper2 output2 [output_params2]> ...]\n"
<< "input1, input2 - paths to databases generated by KMC\n"
<< "oper1, oper2, ..., operN - set operations to be performed on input1 and input2\n"
<< "output1, output2, ..., outputN - paths to output k-mer databases\n"
<< " Available operations:\n"
<< " intersect - output database will contains only k-mers that are present in both input sets\n"
<< " union - output database will contains each k-mer present in any of input sets\n"
<< " kmers_subtract - difference of input sets based on k-mers. \n"
<< " Output database will contains only k-mers that are present in first input set but absent in the second one\n"
<< " counters_subtract - difference of input sets based on k-mers and their counters (weaker version of kmers_subtract).\n"
<< " Output database will contains all k-mers that are present in first input, \n"
<< " beyond those for which counter operation will lead to remove (i.e. counter equal to 0 or negative number)\n"
<< " reverse_kmers_subtract - same as kmers_subtract but treat input2 as first and input1 as second\n"
<< " reverse_counters_subtract - same as counters_subtract but treat input2 as first and input1 as second\n"
<< " For each input there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " For each output there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " -cs<value> - maximal value of a counter\n"
<< " -o<kmc|kff> - output in KMC or KFF format (default: kmc) \n"
<< " -oc<value> - redefine counter calculation mode for equal k-mers\n"
<< " Available values : \n"
<< " min - get lower value of a k-mer counter (default value for intersect operation)\n"
<< " max - get upper value of a k-mer counter\n"
<< " sum - get sum of counters from both databases\n"
<< " diff - get difference between counters (default for counters_subtract operation)\n"
<< " left - get counter from first database (input1)\n"
<< " right - get counter from second database (input2)\n"
<< "Example:\n"
<< "kmc_tools simple kmers1 -ci3 -cx70000 kmers2 union kmers1_kmers2_union -cs65536 -ocfirst intersect intersect_kmers1_kmers2 intersect intersect_max_kmers1_kmers2 -ocmax\n";
}
};
class CTransformOperationUsageDisplayer : public CUsageDisplayer
{
public:
CTransformOperationUsageDisplayer() : CUsageDisplayer("transform"){}
void Display() const override
{
std::cout << "transform operation transforms single input database to output (text file or KMC database)\n"
<< "General syntax:\n"
<< "kmc_tools transform <input> [input_params] <oper1 [oper_params1] output1 [output_params1]> [<oper2 [oper_params2] output2 [output_params2]>...]\n"
<< "input - path to database generated by KMC \n"
<< "oper1, oper2, ..., operN - transform operation name\n"
<< "output1, output2, ..., outputN - paths to output\n"
<< " Available operations:\n"
<< " sort - converts database produced by KMC2.x to KMC1.x database format (which contains k-mers in sorted order)\n"
<< " reduce - exclude too rare and too frequent k-mers\n"
<< " compact - remove counters of k-mers\n"
<< " histogram - produce histogram of k-mers occurrences\n"
<< " dump - produce text dump of kmc database\n"
<< " set_counts <value> - set all k-mer counts to specific value\n"
<< " For input there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " For sort and reduce operations there are additional output_params:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " -cs<value> - maximal value of a counter\n"
<< " For compact, reduce, set_counts and sort operations is an additional output_params:\n"
<< " -o<kmc|kff> - output in KMC or KFF format (default: kmc) \n"
<< " For histogram operation there are additional output_params:\n"
<< " -ci<value> - minimum value of counter to be stored in the otput file\n"
<< " -cx<value> - maximum value of counter to be stored in the otput file\n"
<< " For dump operation there are additional oper_params:\n"
<< " -s - sorted output\n"
<< "Example:\n"
<< "kmc_tools transform db reduce err_kmers -cx10 reduce valid_kmers -ci11 histogram histo.txt dump dump.txt\n";
}
};
class CComplexUsageDisplayer : public CUsageDisplayer
{
public:
CComplexUsageDisplayer() :CUsageDisplayer("complex")
{}
void Display() const override
{
std::cout << "Complex operation allows one to define operations for more than 2 input k-mers sets. Command-line syntax:\n"
<< "kmc_tools complex <operations_definition_file>\n"
<< " operations_definition_file - path to file which define input sets and operations. It is text file with following syntax:\n"
<< " ______________________________________________________________________________ \n"
<< "|INPUT: |\n"
<< "|<input1>=<input1_db_path> [params] |\n"
<< "|<input2>=<input2_db_path> [params] |\n"
<< "|... |\n"
<< "|<inputN>=<inputN_db_path> [params] |\n"
<< "|OUTPUT: |\n"
<< "|<out_db>=<ref_input><oper[c_mode]><ref_input>[<oper[c_mode]><ref_input>[...] |\n"
<< "|[OUTPUT_PARAMS: __|\n"
<< "|<output_params>] | /\n"
<< "| | / \n"
<< "|___________________________________________________________________________|/ \n"
<< "input1, input2, ..., inputN - names of inputs used to define equation\n"
<< "input1_db, input2_db_path, ..., inputN_db_path - paths to k-mers sets\n"
<< "For each input there are additional parameters which can be set:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< "out_db_path - path to output database\n"
<< "ref_input - one of input1, input2, ..., inputN\n"
<< "oper - one of {*,-,~,+}, which refers to {intersect, kmers_subtract, counters_subtract, union}\n"
<< "operator * has the highest priority. Other operators has equal priorities. Order of operations can be changed with parentheses\n"
<< "for {*,~,+} it is possible to redefine counter calculation mode ([c_mode]). Available values: min, max, diff, sum, left, right (detailet description available in simple help message)\n"
<< "output_params are:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " -cs<value> - maximal value of a counter\n"
<< "Example:\n"
<< " __________________________________________________________________ \n"
<< "|INPUT: |\n"
<< "|set1 = kmc_o1 -ci5 |\n"
<< "|set2 = kmc_o2 |\n"
<< "|set3 = kmc_o3 -ci10 -cx100 __|\n"
<< "|OUTPUT: | /\n"
<< "|result = (set3 + min set1) * right set2 | / \n"
<< "|_______________________________________________________________|/ \n";
}
};
class CFilterUsageDisplayer : public CUsageDisplayer
{
public:
CFilterUsageDisplayer() : CUsageDisplayer("filter")
{}
void Display() const override
{
std::cout << " The '" << name << "' is two arguments' operation. General syntax:\n"
<< " kmc_tools " << name << " [filter_params] <kmc_input_db> [kmc_input_db_params] <input_read_set> [input_read_set_params] <output_read_set> [output_read_set_params]\n"
<< " filter_params:\n"
<< " -t - trim reads on first invalid k-mer instead of remove entirely\n"
<< " -hm - hard mask invalid k-mers in a read\n"
<< " kmc_input_db - path to database generated by KMC \n"
<< " input_read_set - path to input set of reads \n"
<< " output_read_set - path to output set of reads \n"
<< " For k-mers' database there are additional parameters:\n"
<< " -ci<value> - exclude k-mers occurring less than <value> times \n"
<< " -cx<value> - exclude k-mers occurring more of than <value> times\n"
<< " For input set of reads there are additional parameters:\n"
<< " -ci<value> - remove reads containing less k-mers than value. It can be integer or floating number in range [0.0;1.0] (default: 2)\n"
<< " -cx<value> - remove reads containing more k-mers than value. It can be integer or floating number in range [0.0;1.0] (default: 1e9)\n"
<< " -f<a/q> - input in FASTA format (-fa), FASTQ format (-fq); default: FASTQ\n"
<< " For output set of reads there are additional parameters:\n"
<< " -f<a/q> - output in FASTA format (-fa), FASTQ format (-fq); default: same as input\n"
<< "Example:\n"
<< "kmc_tools filter kmc_db -ci3 input.fastq -ci0.5 -cx1.0 filtered.fastq\n"
<< "kmc_tools filter kmc_db input.fastq -ci10 -cx100 filtered.fastq\n";
}
};
class CUsageDisplayerFactory
{
std::unique_ptr<CUsageDisplayer> desc;
public:
CUsageDisplayerFactory(CConfig::Mode mode)
{
//TODO: add desc of compare, check and info. Check also if others are not missing
switch (mode)
{
case CConfig::Mode::UNDEFINED:
desc = std::make_unique<CGeneralUsageDisplayer>();
break;
case CConfig::Mode::COMPLEX:
desc = std::make_unique<CComplexUsageDisplayer>();
break;
case CConfig::Mode::COMPARE:
desc = std::make_unique<CGeneralUsageDisplayer>();
break;
case CConfig::Mode::FILTER:
desc = std::make_unique<CFilterUsageDisplayer>();
break;
case CConfig::Mode::SIMPLE_SET:
desc = std::make_unique<CSimpleOperationUsageDisplayer>();
break;
case CConfig::Mode::TRANSFORM:
desc = std::make_unique<CTransformOperationUsageDisplayer>();
break;
default:
desc = std::make_unique<CGeneralUsageDisplayer>();
break;
}
}
const CUsageDisplayer& GetUsageDisplayer()
{
return *desc;
}
};
#endif
// ***** EOF
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