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/////////////////////////////////////////////////////////////////////////////
// File: gnGenomeSpec.cpp
// Purpose: implements gnMultiSpec< gnFragmentSpec > for genomes
// Description:
// Changes:
// Version: libGenome 0.5.1
// Author: Aaron Darling
// Modified by:
// Copyright: (c) Aaron Darling
// Licenses: See COPYING file for details
/////////////////////////////////////////////////////////////////////////////
#ifdef HAVE_CONFIG_H
#include "config.h"
#endif
#include "libGenome/gnGenomeSpec.h"
#include <string>
using namespace std;
namespace genome {
gnGenomeSpec::gnGenomeSpec()
{
gnBaseSpec::Clear();
}
gnGenomeSpec::gnGenomeSpec( const gnGenomeSpec& s )
{
m_sourceName = s.m_sourceName;
m_name = s.m_name;
m_reverseComplement = s.m_reverseComplement;
m_circular = s.m_circular;
//copy the header list.
uint32 list_size = s.m_headerList.size();
m_headerList.reserve(list_size);
for(uint32 i=0; i < list_size; i++)
m_headerList.push_back(s.m_headerList[i]->Clone());
//copy the fragment list.
list_size = s.m_SpecList.size();
m_SpecList.reserve(list_size);
for(uint32 i=0; i < list_size; i++)
m_SpecList.push_back(s.m_SpecList[i]->Clone());
}
gnGenomeSpec::~gnGenomeSpec()
{
Clear();
}
// Clone
void gnGenomeSpec::Clear()
{
uint32 list_size = m_SpecList.size();
for(uint32 i=0; i < list_size; i++)
delete m_SpecList[i];
m_SpecList.clear();
gnMultiSpec< gnFragmentSpec >::Clear();
}
void gnGenomeSpec::SetReverseComplement( const boolean value )
{
if(value == m_reverseComplement)
return;
//reverse the spec list entries
vector<gnFragmentSpec*> tmp_spec_list;
for(uint32 i=0; i < GetSpecListLength(); i++){
//transmit rev_comp down to each fragment spec
GetSpec(i)->SetReverseComplement(!GetSpec(i)->IsReverseComplement());
tmp_spec_list.insert(tmp_spec_list.begin(), GetSpec(i));
}
m_SpecList = tmp_spec_list;
m_reverseComplement = value;
}
gnGenomeSpec* gnGenomeSpec::CloneRange( const gnSeqI startI, const gnSeqI len ) const{
if(len == 0)
return new gnGenomeSpec();
//find the valid range of specs to copy
uint32 firstSpec = GetSpecIndexByBase(startI);
gnSeqI total_copylen = len;
uint32 endSpec;
if(len != GNSEQI_END){
endSpec = GetSpecIndexByBase(startI + len - 1);
}else{
endSpec = GetSpecListLength() - 1;
total_copylen = GetLength() - startI;
}
//find their starting and ending bases
gnSeqI firstBase = startI - GetSpecStartBase(firstSpec);
gnSeqI firstSpecLen = GetSpec(firstSpec)->GetLength();
boolean spans_specs = true;
gnSeqI firstCopyLen = firstSpecLen - firstBase;
if(firstCopyLen >= total_copylen){
spans_specs = false;
firstCopyLen = total_copylen;
}
gnGenomeSpec* destSpec = new gnGenomeSpec();
gnFragmentSpec* newSpec = m_SpecList[firstSpec]->CloneRange(firstBase, firstCopyLen);
destSpec->AddSpec( newSpec );
gnSeqI cur_copylen = firstCopyLen;
//add all the completely covered specs in the middle
for(uint32 specI = firstSpec + 2; specI <= endSpec; specI++){
destSpec->AddSpec(GetSpec(specI-1)->Clone());
cur_copylen += GetSpec(specI-1)->GetLength();
}
//add the last spec if necessary
if(spans_specs){
newSpec = m_SpecList[endSpec]->CloneRange( 0, total_copylen - cur_copylen);
destSpec->AddSpec(newSpec);
}
return destSpec;
}
//IMPLEMENT ME: What to do with headers?
void gnGenomeSpec::MergeFragments(const uint32 startF, const uint32 endF){
if(startF > m_SpecList.size() || endF > m_SpecList.size())
Throw_gnEx(FragmentIndexOutOfBounds());
if(startF > endF)
Throw_gnEx(FragmentIndexOutOfBounds());
for(uint32 i = startF + 1; i < endF; i++){
gnFragmentSpec* delspec = m_SpecList[startF + 1];
m_SpecList.erase(m_SpecList.begin() + startF + 1);
for(uint32 j = 0; j < delspec->GetSpecListLength(); j++)
m_SpecList[startF]->AddSpec(delspec->GetSpec(j));
delete delspec;
}
}
uint32 gnGenomeSpec::AddFeature( gnBaseFeature* feat ){
uint32 count = 0;
uint32 len = 0;
uint32 featureI = 0;
uint32 specListLen = GetSpecListLength();
for(uint32 specI = 0; specI < specListLen; specI++){
len = GetSpec(specI)->GetLength();
gnLocation lt(count, count+len);
if(feat->IsContainedBy(lt)){
return featureI + GetSpec(specI)->AddFeature(feat);
}
count += len;
featureI += GetSpec(specI)->GetFeatureListLength();
}
//if we get this far then the feature has invalid coordinates
Throw_gnEx(SeqIndexOutOfBounds());
}
uint32 gnGenomeSpec::GetFeatureListLength() const
{
uint32 len = 0;
for(uint32 i=0; i < GetSpecListLength(); i++)
len += GetSpec(i)->GetFeatureListLength();
return len;
}
gnBaseFeature* gnGenomeSpec::GetFeature(const uint32 i ) const
{
uint32 count = 0;
uint32 len = 0;
for(uint32 specI=0; specI < GetSpecListLength(); specI++){
len = GetSpec(specI)->GetFeatureListLength();
if(count <= i && i < count + len){
gnBaseFeature* feat = GetSpec(specI)->GetFeature(i - count);
feat->MovePositive(GetSpecStartBase(specI));
return feat;
}
count += len;
}
Throw_gnEx(FeatureIndexOutOfBounds());
}
void gnGenomeSpec::GetContainedFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector, vector<uint32>& index_vector) const{
uint32 ss_size = GetSpecListLength();
uint32 fl_size = 0;
gnSeqI start_base = 0;
for(uint32 i=0; i < ss_size; i++){
gnLocation sub_lt = lt;
gnSeqI sub_len = GetSpec(i)->GetLength();
sub_lt.MoveNegative(start_base);
sub_lt.CropEnd(sub_len);
GetSpec(i)->GetContainedFeatures(sub_lt, feature_vector, index_vector);
uint32 fvs = feature_vector.size();
for(uint32 j = 0; j < fvs; j++){
feature_vector[j]->MovePositive(start_base);
index_vector[j]+= fl_size;
}
if(fvs > 0)
return;
start_base += sub_len;
fl_size += GetSpec(i)->GetFeatureListLength();
}
}
void gnGenomeSpec::GetIntersectingFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector, vector<uint32>& index_vector) const{
uint32 ss_size = GetSpecListLength();
uint32 fl_size = 0;
gnSeqI start_base = 0;
for(uint32 i=0; i < ss_size; i++){
gnLocation sub_lt = lt;
gnSeqI sub_len = GetSpec(i)->GetLength();
sub_lt.MoveNegative(start_base);
sub_lt.CropEnd(sub_len);
GetSpec(i)->GetIntersectingFeatures(sub_lt, feature_vector, index_vector);
uint32 fvs = feature_vector.size();
for(uint32 j = 0; j < fvs; j++){
feature_vector[j]->MovePositive(start_base);
index_vector[j]+= fl_size;
}
if(fvs > 0)
return;
start_base += sub_len;
fl_size += GetSpec(i)->GetFeatureListLength();
}
}
void gnGenomeSpec::GetBrokenFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector) const{
uint32 ss_size = GetSpecListLength();
uint32 fl_size = 0;
gnSeqI start_base = 0;
for(uint32 i=0; i < ss_size; i++){
gnLocation sub_lt = lt;
gnSeqI sub_len = GetSpec(i)->GetLength();
sub_lt.MoveNegative(start_base);
sub_lt.CropEnd(sub_len);
GetSpec(i)->GetBrokenFeatures(sub_lt, feature_vector);
uint32 fvs = feature_vector.size();
for(uint32 j = 0; j < fvs; j++)
feature_vector[j]->MovePositive(start_base);
if(fvs > 0)
return;
start_base += sub_len;
fl_size += GetSpec(i)->GetFeatureListLength();
}
}
void gnGenomeSpec::RemoveFeature( const uint32 i ){
uint32 count = 0;
uint32 len = 0;
uint32 specI=0;
for(; specI < GetSpecListLength(); specI++){
len = GetSpec(specI)->GetFeatureListLength();
if(count <= i && i < count + len){
GetSpec(specI)->RemoveFeature( i - count);
}
count += len;
}
Throw_gnEx(FeatureIndexOutOfBounds());
}
} // end namespace genome
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