File: gnGenomeSpec.cpp

package info (click to toggle)
libgenome 1.3.1-7
  • links: PTS, VCS
  • area: main
  • in suites: jessie, jessie-kfreebsd
  • size: 2,156 kB
  • ctags: 1,212
  • sloc: cpp: 10,910; sh: 8,264; makefile: 79
file content (257 lines) | stat: -rw-r--r-- 7,532 bytes parent folder | download | duplicates (8)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
/////////////////////////////////////////////////////////////////////////////
// File:            gnGenomeSpec.cpp
// Purpose:         implements gnMultiSpec< gnFragmentSpec > for genomes
// Description:     
// Changes:        
// Version:         libGenome 0.5.1 
// Author:          Aaron Darling 
// Modified by:     
// Copyright:       (c) Aaron Darling 
// Licenses:        See COPYING file for details
/////////////////////////////////////////////////////////////////////////////
#ifdef HAVE_CONFIG_H
#include "config.h"
#endif

#include "libGenome/gnGenomeSpec.h"
#include <string>


using namespace std;
namespace genome {


gnGenomeSpec::gnGenomeSpec()
{
	gnBaseSpec::Clear();
}

gnGenomeSpec::gnGenomeSpec( const gnGenomeSpec& s )
{
	m_sourceName = s.m_sourceName;
	m_name = s.m_name;
	m_reverseComplement = s.m_reverseComplement;
	m_circular = s.m_circular;
	//copy the header list.
	uint32 list_size =  s.m_headerList.size();
	m_headerList.reserve(list_size);
	for(uint32 i=0; i < list_size; i++)
		m_headerList.push_back(s.m_headerList[i]->Clone());
	//copy the fragment list.
	list_size =  s.m_SpecList.size();
	m_SpecList.reserve(list_size);
	for(uint32 i=0; i < list_size; i++)
		m_SpecList.push_back(s.m_SpecList[i]->Clone());
}
gnGenomeSpec::~gnGenomeSpec()
{
	Clear();
}
// Clone
void gnGenomeSpec::Clear()
{
	uint32 list_size = m_SpecList.size();
	for(uint32 i=0; i < list_size; i++)
		delete m_SpecList[i];
	m_SpecList.clear();
	gnMultiSpec< gnFragmentSpec >::Clear();
}

void gnGenomeSpec::SetReverseComplement( const boolean value )
{
	if(value == m_reverseComplement)
		return;
	//reverse the spec list entries
	vector<gnFragmentSpec*> tmp_spec_list;
	for(uint32 i=0; i < GetSpecListLength(); i++){
		//transmit rev_comp down to each fragment spec
		GetSpec(i)->SetReverseComplement(!GetSpec(i)->IsReverseComplement());
		tmp_spec_list.insert(tmp_spec_list.begin(), GetSpec(i));
	}
	m_SpecList = tmp_spec_list;
	m_reverseComplement = value;
}

gnGenomeSpec* gnGenomeSpec::CloneRange( const gnSeqI startI, const gnSeqI len ) const{
	if(len == 0)
		return new gnGenomeSpec();

	//find the valid range of specs to copy
	uint32 firstSpec = GetSpecIndexByBase(startI);
	gnSeqI total_copylen = len;
	uint32 endSpec;
	if(len != GNSEQI_END){
		endSpec = GetSpecIndexByBase(startI + len - 1);
	}else{
		endSpec = GetSpecListLength() - 1;
		total_copylen = GetLength() - startI;
	}

	//find their starting and ending bases
	gnSeqI firstBase = startI - GetSpecStartBase(firstSpec);
	gnSeqI firstSpecLen = GetSpec(firstSpec)->GetLength();
	boolean spans_specs = true;
	gnSeqI firstCopyLen = firstSpecLen - firstBase;
	if(firstCopyLen >= total_copylen){
		spans_specs = false;
		firstCopyLen = total_copylen;
	}
	
	gnGenomeSpec* destSpec = new gnGenomeSpec();
	gnFragmentSpec* newSpec = m_SpecList[firstSpec]->CloneRange(firstBase, firstCopyLen);
	destSpec->AddSpec( newSpec );

	gnSeqI cur_copylen = firstCopyLen;
	//add all the completely covered specs in the middle
	for(uint32 specI = firstSpec + 2; specI <= endSpec; specI++){
		destSpec->AddSpec(GetSpec(specI-1)->Clone());
		cur_copylen += GetSpec(specI-1)->GetLength();
	}
	//add the last spec if necessary
	if(spans_specs){
		newSpec = m_SpecList[endSpec]->CloneRange( 0, total_copylen - cur_copylen);
		destSpec->AddSpec(newSpec);
	}
	return destSpec;
}


//IMPLEMENT ME: What to do with headers?
void gnGenomeSpec::MergeFragments(const uint32 startF, const uint32 endF){
	if(startF > m_SpecList.size() || endF > m_SpecList.size())
		Throw_gnEx(FragmentIndexOutOfBounds());
	if(startF > endF)
		Throw_gnEx(FragmentIndexOutOfBounds());
	
	for(uint32 i = startF + 1; i < endF; i++){
		gnFragmentSpec* delspec = m_SpecList[startF + 1];
		m_SpecList.erase(m_SpecList.begin() + startF + 1);

		for(uint32 j = 0; j < delspec->GetSpecListLength(); j++)
			m_SpecList[startF]->AddSpec(delspec->GetSpec(j));
		delete delspec;
	}
}

uint32 gnGenomeSpec::AddFeature( gnBaseFeature* feat ){
	uint32 count = 0;
	uint32 len = 0;
	uint32 featureI = 0;
	uint32 specListLen = GetSpecListLength();

	for(uint32 specI = 0; specI < specListLen; specI++){
		len = GetSpec(specI)->GetLength();
		gnLocation lt(count, count+len);
		if(feat->IsContainedBy(lt)){
			return featureI + GetSpec(specI)->AddFeature(feat);
		}
		count += len;
		featureI += GetSpec(specI)->GetFeatureListLength();
	}
	//if we get this far then the feature has invalid coordinates
	Throw_gnEx(SeqIndexOutOfBounds());
}

uint32 gnGenomeSpec::GetFeatureListLength() const
{
	uint32 len = 0;
	for(uint32 i=0; i < GetSpecListLength(); i++)
		len += GetSpec(i)->GetFeatureListLength();
	return len;
}

gnBaseFeature* gnGenomeSpec::GetFeature(const uint32 i ) const
{
	uint32 count = 0;
	uint32 len = 0;
	for(uint32 specI=0; specI < GetSpecListLength(); specI++){
		len = GetSpec(specI)->GetFeatureListLength();
		if(count <= i && i < count + len){
			gnBaseFeature* feat = GetSpec(specI)->GetFeature(i - count);
			feat->MovePositive(GetSpecStartBase(specI));
			return feat;
		}
		count += len;
	}
	Throw_gnEx(FeatureIndexOutOfBounds());
}

void gnGenomeSpec::GetContainedFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector, vector<uint32>& index_vector) const{
	uint32 ss_size = GetSpecListLength();
	uint32 fl_size = 0;
	gnSeqI start_base = 0;
	for(uint32 i=0; i < ss_size; i++){
		gnLocation sub_lt = lt;
		gnSeqI sub_len = GetSpec(i)->GetLength();
		sub_lt.MoveNegative(start_base);
		sub_lt.CropEnd(sub_len);
		GetSpec(i)->GetContainedFeatures(sub_lt, feature_vector, index_vector);
		uint32 fvs = feature_vector.size();
		for(uint32 j = 0; j < fvs; j++){
			feature_vector[j]->MovePositive(start_base);
			index_vector[j]+= fl_size;
		}
		if(fvs > 0)
			return;
		start_base += sub_len;
		fl_size += GetSpec(i)->GetFeatureListLength();
	}
}

void gnGenomeSpec::GetIntersectingFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector, vector<uint32>& index_vector) const{
	uint32 ss_size = GetSpecListLength();
	uint32 fl_size = 0;
	gnSeqI start_base = 0;
	for(uint32 i=0; i < ss_size; i++){
		gnLocation sub_lt = lt;
		gnSeqI sub_len = GetSpec(i)->GetLength();
		sub_lt.MoveNegative(start_base);
		sub_lt.CropEnd(sub_len);
		GetSpec(i)->GetIntersectingFeatures(sub_lt, feature_vector, index_vector);
		uint32 fvs = feature_vector.size();
		for(uint32 j = 0; j < fvs; j++){
			feature_vector[j]->MovePositive(start_base);
			index_vector[j]+= fl_size;
		}
		if(fvs > 0)
			return;
		start_base += sub_len;
		fl_size += GetSpec(i)->GetFeatureListLength();
	}
}
void gnGenomeSpec::GetBrokenFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector) const{
	uint32 ss_size = GetSpecListLength();
	uint32 fl_size = 0;
	gnSeqI start_base = 0;
	for(uint32 i=0; i < ss_size; i++){
		gnLocation sub_lt = lt;
		gnSeqI sub_len = GetSpec(i)->GetLength();
		sub_lt.MoveNegative(start_base);
		sub_lt.CropEnd(sub_len);
		GetSpec(i)->GetBrokenFeatures(sub_lt, feature_vector);
		uint32 fvs = feature_vector.size();
		for(uint32 j = 0; j < fvs; j++)
			feature_vector[j]->MovePositive(start_base);
		if(fvs > 0)
			return;
		start_base += sub_len;
		fl_size += GetSpec(i)->GetFeatureListLength();
	}
}

void gnGenomeSpec::RemoveFeature( const uint32 i ){
	uint32 count = 0;
	uint32 len = 0;
	uint32 specI=0;
	for(; specI < GetSpecListLength(); specI++){
		len = GetSpec(specI)->GetFeatureListLength();
		if(count <= i && i < count + len){
			GetSpec(specI)->RemoveFeature( i - count);
		}
		count += len;
	}
	Throw_gnEx(FeatureIndexOutOfBounds());
}

}	// end namespace genome