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//*****************************************************************************
//
// File: MaximumParsimonyExhSeq.java
// Package: edu.rit.compbio.phyl
// Unit: Class edu.rit.compbio.phyl.MaximumParsimonyExhSeq
//
// This Java source file is copyright (C) 2008 by Alan Kaminsky. All rights
// reserved. For further information, contact the author, Alan Kaminsky, at
// ark@cs.rit.edu.
//
// This Java source file is part of the Parallel Java Library ("PJ"). PJ is free
// software; you can redistribute it and/or modify it under the terms of the GNU
// General Public License as published by the Free Software Foundation; either
// version 3 of the License, or (at your option) any later version.
//
// PJ is distributed in the hope that it will be useful, but WITHOUT ANY
// WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR
// A PARTICULAR PURPOSE. See the GNU General Public License for more details.
//
// Linking this library statically or dynamically with other modules is making a
// combined work based on this library. Thus, the terms and conditions of the
// GNU General Public License cover the whole combination.
//
// As a special exception, the copyright holders of this library give you
// permission to link this library with independent modules to produce an
// executable, regardless of the license terms of these independent modules, and
// to copy and distribute the resulting executable under terms of your choice,
// provided that you also meet, for each linked independent module, the terms
// and conditions of the license of that module. An independent module is a
// module which is not derived from or based on this library. If you modify this
// library, you may extend this exception to your version of the library, but
// you are not obligated to do so. If you do not wish to do so, delete this
// exception statement from your version.
//
// A copy of the GNU General Public License is provided in the file gpl.txt. You
// may also obtain a copy of the GNU General Public License on the World Wide
// Web at http://www.gnu.org/licenses/gpl.html.
//
//******************************************************************************
package edu.rit.compbio.phyl;
/**
* Class MaximumParsimonyExhSeq provides a sequential algorithm for maximum
* parsimony phylogenetic tree construction using exhaustive search.
* <P>
* To perform a search, the program must:
* <OL TYPE=1>
* <LI>
* Create an instance of class MaximumParsimonyExhSeq, passing in a {@linkplain
* DnaSequenceList} of the DNA sequences in the tree and a {@linkplain
* MaximumParsimonyResults} object to hold the search results.
* <P><LI>
* Call the <TT>findTrees()</TT> method. The results of the search are returned
* in the {@linkplain MaximumParsimonyResults} object specified to the
* constructor.
* </OL>
* <P>
* <I>Note:</I> Class MaximumParsimonyExhSeq is not multiple thread safe; it is
* intended to be used in a single-threaded program.
*
* @author Alan Kaminsky
* @version 21-Nov-2008
*/
public class MaximumParsimonyExhSeq
{
// Hidden data members.
// List of DNA sequences with which to construct trees.
private DnaSequenceList seqList;
// For holding search results.
private MaximumParsimonyResults results;
// Length of each DNA sequence.
private int L;
// Number of DNA sequences.
private int N;
// Tree capacity.
private int C;
// Stack of DNA sequence trees.
private DnaSequenceTree[] treeStack;
// Stack of auxiliary DNA sequence arrays.
DnaSequence[][] seqArrayStack;
// Tree signature currently being searched.
private int[] signature;
// Exported constructors.
/**
* Construct a new maximum parsimony phylogenetic tree construction
* algorithm object.
*
* @param seqList DNA sequence list.
* @param results Object in which to store the results.
*/
public MaximumParsimonyExhSeq
(DnaSequenceList seqList,
MaximumParsimonyResults results)
{
// Record parameters.
this.seqList = seqList;
this.results = results;
// Initialize.
L = seqList.seq(0).length();
N = seqList.length();
C = 2*N - 1;
// Set up stack of DNA sequence trees.
treeStack = new DnaSequenceTree [N];
for (int i = 0; i < N; ++ i)
{
treeStack[i] = new DnaSequenceTree (C);
}
// Initialize DNA sequence tree at first level of the search graph.
treeStack[0].add (0, seqList.seq(0));
// Set up stack of auxiliary DNA sequence arrays.
seqArrayStack = new DnaSequence [N] [];
for (int i = 0; i < N; ++ i)
{
DnaSequence[] seqArray = new DnaSequence [i];
seqArrayStack[i] = seqArray;
for (int j = 0; j < i; ++ j)
{
seqArray[j] = new DnaSequence (L);
}
}
// Set up tree signature.
signature = new int [N];
}
// Exported operations.
/**
* Find the maximum parsimony phylogenetic tree(s) in the search graph. The
* DNA sequence list was specified to the constructor. The results are
* stored in the {@linkplain MaximumParsimonyResults} object specified to
* the constructor.
*/
public void findTrees()
{
// Initialize tree signature as specified by <startLevel> and <vertex1>.
signature[0] = 0;
for (int i = 1; i < N; ++ i)
{
signature[i] = -1;
}
// Traverse all levels of the search graph.
int level = 1;
boolean done = false;
results.clear();
while (! done)
{
DnaSequenceTree prevTree = treeStack[level-1];
// If we have reached the bottom of the search graph, we have a
// tentative solution.
if (level == N)
{
int tentativeScore = prevTree.seq (prevTree.root()) .score();
// Record tentative solution.
results.add (signature, tentativeScore);
// Go to previous level.
-- level;
if (level == 1) done = true;
}
// If there are no more positions to try at this level, reset
// position at this level and go to previous level.
else if (signature[level] == 2*(level - 1))
{
signature[level] = -1;
-- level;
if (level == 1) done = true;
}
// If there are more positions to try at this level, add the DNA
// sequence to the tree at the next position and go to next level.
else
{
++ signature[level];
DnaSequenceTree currTree = treeStack[level];
currTree.copy (prevTree);
int tip = currTree.add (signature[level], seqList.seq(level));
FitchParsimony.updateScore
(currTree, tip, seqArrayStack[level]);
++ level;
}
}
}
}
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