1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
|
CLUSTAL alignment of sequences Human_IR and Mouse_IR
Human_IR TCAGAGATGTCCACCTGCGCCCTATTCGAGGTCTCCGGCGTCTTCTTTGGCGTCGTCTTT
Mouse_IR ------------------------------------------------------------
Human_IR GCCCTTTCAGAAGCGTCTGCACATTTTTCCAGGTGTCATTTCTCCAACTTGAACACAGGG
Mouse_IR ------------------------------------------------------------
Human_IR AGCGCACTGGGCACGCGGGCACGTGGCTGTCCCCAGGGGCCTGGCTTGGGTCTCGCCCCT
Mouse_IR ------------------------------------------------------------
Human_IR GGGCCGGGGCGCACGCGCGGGCGGGACATCTGGGGGCGCCCACGCGCTCTGGGACGAGTG
Mouse_IR ------------------------------------------------------------
Human_IR TCGCTGGCCAGGCCCGGACTGAGGAAAGGCGAGTGAGACACTACTCGCCTGGGGTGCAAA
Mouse_IR ------------------------------------------------------------
Human_IR ATTTAAGGGAGTGAAAAAAAAAAAAAAAGAAAGAAACCAAAACCACCTCGAGTCACCAAA
Mouse_IR ------------------------------------------------------------
Human_IR ATAAACATTTTAATGCAGTATTTTTTAAAAAATCAACAGGAATCCTCCAAAGCCCACTAT
Mouse_IR --------------------------------------------CCACGGGAGTCAAAAA
* * ** *
Human_IR GAACAAAATAGCAAAATGGTAGAGAAAGGATCTGTGCCGCTGCGTCGGGCCTGT------
Mouse_IR AATAGTAAAAAGGAGTAAAGAAAGACAAAATGTGCTTGGTTGAATCTGGCATCTAGGGCA
* ** * * * *** * ** ** * ** ** *** * *
Human_IR ------------------------------------------------------------
Mouse_IR TATTGGGGTGTTTATGTCCTGGGGTATCTGGCGGCATTTCCAGACTTTAAAATTGTTATT
Human_IR --G---------------------------------------------------------
Mouse_IR TCGGGGTAATTTGGGGTGTCTCGCTCTGGCGGAGATCTAGAGTGTGCTCCAGACCTTTAA
*
Human_IR ------------------------------------------------------------
Mouse_IR ATTGGAACCTCGGTGTTACTTGTGTTTGCTGCAGTCAGGAGGGGACCTGGGGGCGTCCCT
Human_IR ------------------------------------------------------------
Mouse_IR AGGCTTTTAAACTGGAACCTCAGGCCTGTTTAGTGGTTTTCGAGTCAGGCGGGGATCTGG
Human_IR ------------------------------------------------------------
Mouse_IR GGACCCCTAGGTTTTAAAATCGGAACTTTGGGACTCTTTGGGGGCGTTCGTGTCAGGTGC
Human_IR ------GGGCGCCTCCGGGGGTCTGAAACTGGAG--------------------------
Mouse_IR GGATATGGGCAGCTCCGGACGTTTGACAGGTGAGTCTTAGAGTTGTTTGGGTGTTTATGT
**** ****** ** *** * ***
Human_IR ------------------------------------------------------------
Mouse_IR TACACTGGTATCTGAGAACGCTTACAAGCTTTTAAATCGTAATCTTTCTAAGCCAGCAGT
Human_IR --------------------------------------------------------GAGA
Mouse_IR TCGGGGTGTTGGGATTGGAAGAATCTGAAGTGAGCCTCGGGTCTCTGAAGTTGCGGGTTT
*
Human_IR CTCGGGGCTGTAGGGCGCGCGGATCTGGGGCGCGCCCTCGGTCCCGGCGCGCCCAGGGCC
Mouse_IR TACGGGGC----------------------------------------------------
******
Human_IR TCCCGCGCGGGGCCCGGCACAGGGAGGCGGGGAGGCGGGCGGGGCGGGGCG-----GGAC
Mouse_IR ----AAGGGGGAAAGGGGCCGAGGAGGCGAGGAGGCGAG-GAGGCGTGGCGTTGCCAGCT
* *** ** * ******* ******* * * **** **** *
Human_IR CGGGCGGCACCTCCC--TCCCCTGCAAGCTTT----CCCTCCCTCTCC--TGGGCCTCTC
Mouse_IR CTGGCCACGCCTCCCCGAGCTCTGCTGGCTTTCTCCCCCTCCCCCCCCAGCGGGCCTCAC
* *** * ****** * **** ***** ******* * ** ******* *
Human_IR CCGGGCGCAGAGTCCCTTCCTAGGCCAGATCCGCGCCGCCTTTTCCCGCGGCCCGCACGG
Mouse_IR TGGAGCGCACAGTCCCTTCCCTGTCTTAATCCGCGCCACCTTTTCCCTTGGCCCGCGCGG
* ***** ********** * * ********* ********* ******* ***
Human_IR GGCCCAGCTGACGGGCCGCGTTGTTTACGGGCCGGAG-C-AGCCCTCTCTCCCGCCGCCC
Mouse_IR G-CCCAGCTGACGGGCTGCGTTGTTTACGGGCTGGAGTCGAGCCCTAGCTCCCGCCGCC-
* ************** *************** **** * ****** ***********
Human_IR GCCCGCCACCCGCCAGCCCAGGTGCCCGCCCGCCAGTCAGCTAGTCCGTCGGTCCGCGCG
Mouse_IR --------ACCACCAGCCCAGGTGCCC--------------------TCCAGTGCGCGCG
** *************** * ** ******
Human_IR TCCCTCTGTCCCGGAGCCCGCAGATCGCGACCCAGAGCGCGCGGGGCCGAGAGCCGAGAG
Mouse_IR TCCCTCTGTCTCAGACTCCACACAACGCGACCCA--------------------------
********** * ** ** ** * *********
Human_IR ACAGTCCCG----------------------------------------GGCGCAGCGCG
Mouse_IR ------CCCAGAGCTGCACGGAGGGCAGAAGCAGGAGACCCGGACAGGAGACGCACCGCG
** * **** ****
Human_IR GAG--CTCCGGGCCCCGAGATCCTGGGACGGGGCCCGGGCCGCAGCGGCCGGGGGGTCGG
Mouse_IR GTGAGCTCTGGACTCTGGGATTGCGGGCAC----------------------------GG
* * *** ** * * * *** *** **
Human_IR GGCC-------ACCACCGCAAGGGCCTCCGCTCAGTATTTGTAGCTGGCGAAGCCGCGCG
Mouse_IR GACCGGGCCTGGGTGACCTGCGGGCCGCGCCACGGTGTTGCTTGCGGCCGAGGCCTCT-G
* ** * ***** * * * ** ** * ** * *** *** * *
Human_IR CGCCCTTCCCGGGGCTG-CCTCTGGGCCCTCCCCGGCAGGGGGGCTGCGGCCCGCGGGTC
Mouse_IR TGCTCTTCCCGGGACTGTCCCCAGGGCCCT-CTAGGCTGGAGAGCTGCGGCCTGTGAGCC
** ********* *** ** * ******* * *** ** * ********* * * * *
Human_IR GCGGGCGTGGAAGAGAAGGACGCGCGGCCCCCAGCGCCTCTTGGGTGGCCG-C-CTCGGA
Mouse_IR ACGGGCGTGGAAGAGAAGGACGTGCGGCCCCGAGCGCCTCTCCAGAGACCTTCTCACGGA
********************* ******** ********* * * ** * * ****
Human_IR GCATGACCCCCGCGGGCCAGCGCCGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCA
Mouse_IR GTATGTCCCCAGTAGGCCGGCGTGGCGTGCTCTGATCGCCGGGGTCCCAGCACTCCTACT
* *** **** * **** *** *** ********* ** * *** ** **** *
Human_IR GCCATGGGCACCGGGGGCCGGCGGGGAG-CGGCGGCCGCGCCGCTGCTGGTGGCGGTGGC
Mouse_IR GCTATGGGCTTCGGGAGA-GGATGTGAGACGACGGCTGTGCCATTGCTGGTGGCCGTGGC
** ****** **** * ** * *** ** **** * *** ********** *****
Human_IR CGCGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGGTGAGTCTGGGGGCGC
Mouse_IR CGCGTTGCTGGTGGGCACAGCCGGCCACCTGTACCCTGGAGAGGGTAAGTCTGG------
**** **** ***** * ** ************** ********* *******
Human_IR GGGCGTGGGCGGGGAGCGCCGCGATGGGGAGAGGACCCCACCCAAGCCAAAATCGATCCC
Mouse_IR ------------------------------------------------------------
Human_IR CCGCTTGTGGACTGAGAACCCTCCCCAGGGGCGGGGGGCGGTGGCCAGGACGGTAGCTCC
Mouse_IR ------------------------------------------------------------
Human_IR TGCATCGCGTAGGGGGAGCGGGAAGC
Mouse_IR --------------------------
|
