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/*
* The MIT License
*
* Wavefront Alignment Algorithms
* Copyright (c) 2017 by Santiago Marco-Sola <santiagomsola@gmail.com>
*
* This file is part of Wavefront Alignment Algorithms.
*
* Permission is hereby granted, free of charge, to any person obtaining a copy
* of this software and associated documentation files (the "Software"), to deal
* in the Software without restriction, including without limitation the rights
* to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
* copies of the Software, and to permit persons to whom the Software is
* furnished to do so, subject to the following conditions:
*
* The above copyright notice and this permission notice shall be included in all
* copies or substantial portions of the Software.
*
* THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
* IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
* FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
* AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
* LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
* OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
* SOFTWARE.
*
* PROJECT: Wavefront Alignment Algorithms
* AUTHOR(S): Santiago Marco-Sola <santiagomsola@gmail.com>
* DESCRIPTION: Benchmark utils
*/
#include "benchmark_check.h"
#include "alignment/score_matrix.h"
#include "indel/indel_dp.h"
#include "edit/edit_dp.h"
#include "gap_linear/nw.h"
#include "gap_affine/affine_matrix.h"
#include "gap_affine/swg.h"
#include "gap_affine2p/affine2p_dp.h"
/*
* Checker (given the correct CIGAR+SCORE)
*/
void benchmark_check_alignment_using_solution(
align_input_t* const align_input,
cigar_t* const cigar_computed,
const int score_computed,
cigar_t* const cigar_correct,
const int score_correct) {
counter_add(&(align_input->align),1);
counter_add(&(align_input->align_score_total),ABS(score_computed));
// Debug
if (align_input->debug_flags) {
// Display info
if (align_input->debug_flags & ALIGN_DEBUG_DISPLAY_INFO) {
benchmark_print_alignment(stderr,align_input,score_computed,cigar_computed,-1,NULL);
}
// Check correct
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_CORRECT) {
bool correct = cigar_check_alignment(stderr,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,
cigar_computed,align_input->verbose);
if (!correct) {
// Print
if (align_input->verbose) {
fprintf(stderr,"INCORRECT ALIGNMENT\n");
benchmark_print_alignment(stderr,align_input,-1,cigar_computed,-1,NULL);
}
// Quit
return;
} else {
counter_add(&(align_input->align_correct),1);
}
// CIGAR Stats
int i;
counter_add(&(align_input->align_bases),align_input->pattern_length);
for (i=cigar_computed->begin_offset;i<cigar_computed->end_offset;++i) {
switch (cigar_computed->operations[i]) {
case 'M': counter_add(&(align_input->align_matches),1); break;
case 'X': counter_add(&(align_input->align_mismatches),1); break;
case 'I': counter_add(&(align_input->align_ins),1); break;
case 'D': default: counter_add(&(align_input->align_del),1); break;
}
}
}
// Check score
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_SCORE) {
if (score_computed != score_correct) {
// Print
if (align_input->verbose) {
benchmark_print_alignment(
stderr,align_input,
score_computed,cigar_computed,
score_correct,cigar_correct);
fprintf(stderr,"(#%d)\t INACCURATE SCORE computed=%d\tcorrect=%d\n",
align_input->sequence_id,score_computed,score_correct);
}
counter_add(&(align_input->align_score_diff),ABS(score_computed-score_correct));
// Quit
return;
} else {
counter_add(&(align_input->align_score),1);
}
}
// Check alignment
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_ALIGNMENT) {
if (cigar_cmp(cigar_computed,cigar_correct) != 0) {
// Print
if (align_input->verbose) {
fprintf(stderr,"INACCURATE ALIGNMENT\n");
benchmark_print_alignment(
stderr,align_input,
-1,cigar_computed,
-1,cigar_correct);
}
// Quit
return;
} else {
counter_add(&(align_input->align_cigar),1);
}
}
}
}
/*
* Specialized Checkers
*/
void benchmark_check_alignment_indel(
align_input_t* const align_input,
cigar_t* const cigar_computed) {
score_matrix_t score_matrix;
score_matrix_allocate(
&score_matrix,align_input->pattern_length+1,
align_input->text_length+1,align_input->mm_allocator);
cigar_t* const cigar = cigar_new(
align_input->pattern_length+align_input->text_length,
align_input->mm_allocator);
indel_dp_compute(&score_matrix,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,cigar);
const int score_correct = cigar_score_edit(cigar);
const int score_computed = cigar_score_edit(cigar_computed);
// Check alignment
benchmark_check_alignment_using_solution(
align_input,cigar_computed,score_computed,
cigar,score_correct);
// Free
score_matrix_free(&score_matrix);
cigar_free(cigar);
}
void benchmark_check_alignment_edit(
align_input_t* const align_input,
cigar_t* const cigar_computed) {
score_matrix_t score_matrix;
score_matrix_allocate(
&score_matrix,align_input->pattern_length+1,
align_input->text_length+1,align_input->mm_allocator);
cigar_t* const cigar = cigar_new(
align_input->pattern_length+align_input->text_length,
align_input->mm_allocator);
if (align_input->check_bandwidth <= 0) {
edit_dp_align(&score_matrix,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,cigar);
} else {
edit_dp_align_banded(&score_matrix,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,
align_input->check_bandwidth,cigar);
}
const int score_correct = cigar_score_edit(cigar);
const int score_computed = cigar_score_edit(cigar_computed);
// Check alignment
benchmark_check_alignment_using_solution(
align_input,cigar_computed,score_computed,
cigar,score_correct);
// Free
score_matrix_free(&score_matrix);
cigar_free(cigar);
}
void benchmark_check_alignment_gap_linear(
align_input_t* const align_input,
cigar_t* const cigar_computed) {
// Compute correct
score_matrix_t score_matrix;
score_matrix_allocate(
&score_matrix,align_input->pattern_length+1,
align_input->text_length+1,align_input->mm_allocator);
cigar_t* const cigar = cigar_new(
align_input->pattern_length+align_input->text_length,
align_input->mm_allocator);
nw_align(&score_matrix,
align_input->check_linear_penalties,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,cigar);
const int score_correct = cigar_score_gap_linear(
cigar,align_input->check_linear_penalties);
const int score_computed = cigar_score_gap_linear(
cigar_computed,align_input->check_linear_penalties);
// Check alignment
benchmark_check_alignment_using_solution(
align_input,cigar_computed,score_computed,
cigar,score_correct);
// Free
score_matrix_free(&score_matrix);
cigar_free(cigar);
}
void benchmark_check_alignment_gap_affine(
align_input_t* const align_input,
cigar_t* const cigar_computed) {
// Allocate
affine_matrix_t affine_matrix;
affine_matrix_allocate(
&affine_matrix,align_input->pattern_length+1,
align_input->text_length+1,align_input->mm_allocator);
cigar_t* const cigar = cigar_new(
align_input->pattern_length+align_input->text_length,
align_input->mm_allocator);
// Compute correct
if (align_input->check_bandwidth <= 0) {
swg_align(&affine_matrix,align_input->check_affine_penalties,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,cigar);
} else {
swg_align_banded(&affine_matrix,align_input->check_affine_penalties,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,
align_input->check_bandwidth,cigar);
}
const int score_correct = cigar_score_gap_affine(
cigar,align_input->check_affine_penalties);
const int score_computed = cigar_score_gap_affine(
cigar_computed,align_input->check_affine_penalties);
// Check alignment
benchmark_check_alignment_using_solution(
align_input,cigar_computed,score_computed,
cigar,score_correct);
// Free
affine_matrix_free(&affine_matrix,align_input->mm_allocator);
cigar_free(cigar);
}
void benchmark_check_alignment_gap_affine2p(
align_input_t* const align_input,
cigar_t* const cigar_computed) {
// Allocate
affine2p_matrix_t affine_matrix;
affine2p_matrix_allocate(
&affine_matrix,align_input->pattern_length+1,
align_input->text_length+1,align_input->mm_allocator);
cigar_t* const cigar = cigar_new(
align_input->pattern_length+align_input->text_length,
align_input->mm_allocator);
// Compute correct
affine2p_dp_align(
&affine_matrix,align_input->check_affine2p_penalties,
align_input->pattern,align_input->pattern_length,
align_input->text,align_input->text_length,cigar);
const int score_correct = cigar_score_gap_affine2p(
cigar,align_input->check_affine2p_penalties);
const int score_computed = cigar_score_gap_affine2p(
cigar_computed,align_input->check_affine2p_penalties);
// Check alignment
benchmark_check_alignment_using_solution(
align_input,cigar_computed,score_computed,
cigar,score_correct);
// Free
affine2p_matrix_free(&affine_matrix,align_input->mm_allocator);
cigar_free(cigar);
}
/*
* Check
*/
void benchmark_check_alignment(
align_input_t* const align_input,
cigar_t* const cigar_computed) {
// Compute correct CIGAR
if ((align_input->debug_flags & ALIGN_DEBUG_CHECK_SCORE) ||
(align_input->debug_flags & ALIGN_DEBUG_CHECK_ALIGNMENT)) {
// Check gap-affine-2p
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_DISTANCE_METRIC_GAP_AFFINE2P) {
benchmark_check_alignment_gap_affine2p(align_input,cigar_computed);
}
// Check gap-affine
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_DISTANCE_METRIC_GAP_AFFINE) {
benchmark_check_alignment_gap_affine(align_input,cigar_computed);
}
// Check gap-linear
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_DISTANCE_METRIC_GAP_LINEAR) {
benchmark_check_alignment_gap_linear(align_input,cigar_computed);
}
// Check edit
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_DISTANCE_METRIC_EDIT) {
benchmark_check_alignment_edit(align_input,cigar_computed);
}
// Check indel
if (align_input->debug_flags & ALIGN_DEBUG_CHECK_DISTANCE_METRIC_INDEL) {
benchmark_check_alignment_indel(align_input,cigar_computed);
}
} else if ((align_input->debug_flags & ALIGN_DEBUG_CHECK_CORRECT) ||
(align_input->debug_flags & ALIGN_DEBUG_DISPLAY_INFO)) { // Check CORRECT or just DISPLAY
// Delegate check alignment
benchmark_check_alignment_using_solution(
align_input,cigar_computed,-1,NULL,-1);
}
}
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