File: wavefront_aligner.c

package info (click to toggle)
libwfa2 2.3.3-4
  • links: PTS, VCS
  • area: main
  • in suites: forky, sid, trixie
  • size: 10,072 kB
  • sloc: ansic: 13,812; python: 540; cpp: 500; makefile: 268; sh: 176; lisp: 41
file content (490 lines) | stat: -rw-r--r-- 17,884 bytes parent folder | download | duplicates (2)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
/*
 *                             The MIT License
 *
 * Wavefront Alignment Algorithms
 * Copyright (c) 2017 by Santiago Marco-Sola  <santiagomsola@gmail.com>
 *
 * This file is part of Wavefront Alignment Algorithms.
 *
 * Permission is hereby granted, free of charge, to any person obtaining a copy
 * of this software and associated documentation files (the "Software"), to deal
 * in the Software without restriction, including without limitation the rights
 * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
 * copies of the Software, and to permit persons to whom the Software is
 * furnished to do so, subject to the following conditions:
 *
 * The above copyright notice and this permission notice shall be included in all
 * copies or substantial portions of the Software.
 *
 * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
 * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
 * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
 * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
 * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
 * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
 * SOFTWARE.
 *
 * PROJECT: Wavefront Alignment Algorithms
 * AUTHOR(S): Santiago Marco-Sola <santiagomsola@gmail.com>
 * DESCRIPTION: WaveFront aligner data structure
 */

#include "utils/commons.h"
#include "wavefront_aligner.h"
#include "wavefront_components.h"
#include "wavefront_heuristic.h"
#include "wavefront_plot.h"

/*
 * Configuration
 */
#define PATTERN_LENGTH_INIT 1000
#define TEXT_LENGTH_INIT    1000

/*
 * Error messages
 */
char* wf_error_msg[] =
{
  /* WF_STATUS_OOM                  == -3 */ "[WFA] Alignment failed. Maximum memory threshold reached",
  /* WF_STATUS_MAX_SCORE_REACHED    == -2 */ "[WFA] Alignment failed. Maximum score reached",
  /* WF_STATUS_UNFEASIBLE           == -1 */ "[WFA] Alignment unfeasible (possible due to heuristic parameters)",
  /* WF_STATUS_SUCCESSFUL           ==  0 */ "[WFA] Alignment finished successfully",
};
char* wavefront_align_strerror(const int error_code) {
  if (error_code > 0) {
    fprintf(stderr,"[WFA] Internal alignment error code (%d)",error_code);
    exit(1);
  }
  return wf_error_msg[error_code+3];
}
/*
 * Setup
 */
wavefront_aligner_t* wavefront_aligner_init_mm(
    mm_allocator_t* mm_allocator,
    const bool memory_modular,
    const bool bt_piggyback,
    const bool bi_alignment) {
  // MM
  bool mm_allocator_own;
  if (mm_allocator == NULL) {
    mm_allocator = mm_allocator_new((bi_alignment) ? BUFFER_SIZE_4K : BUFFER_SIZE_4M);
    mm_allocator_own = true;
  } else {
    mm_allocator_own = false;
  }
  // Handler
  wavefront_aligner_t* const wf_aligner =
      mm_allocator_alloc(mm_allocator,wavefront_aligner_t);
  // Configure MM
  wf_aligner->mm_allocator = mm_allocator;
  wf_aligner->mm_allocator_own = mm_allocator_own;
  // Slab
  if (bi_alignment) {
    wf_aligner->wavefront_slab = NULL;
  } else {
    const wf_slab_mode_t slab_mode = (memory_modular) ? wf_slab_reuse : wf_slab_tight;
    wf_aligner->wavefront_slab = wavefront_slab_new(1000,bt_piggyback,slab_mode,wf_aligner->mm_allocator);
  }
  // Return
  return wf_aligner;
}
void wavefront_aligner_init_penalties(
    wavefront_aligner_t* const wf_aligner,
    wavefront_aligner_attr_t* const attributes) {
  switch (attributes->distance_metric) {
    case indel:
      wavefront_penalties_set_indel(&wf_aligner->penalties);
      break;
    case edit:
      wavefront_penalties_set_edit(&wf_aligner->penalties);
      break;
    case gap_linear:
      wavefront_penalties_set_linear(
          &wf_aligner->penalties,
          &attributes->linear_penalties);
      break;
    case gap_affine:
      wavefront_penalties_set_affine(
          &wf_aligner->penalties,
          &attributes->affine_penalties);
      break;
    case gap_affine_2p:
      wavefront_penalties_set_affine2p(
          &wf_aligner->penalties,
          &attributes->affine2p_penalties);
      break;
  }
}
void wavefront_aligner_init_heuristic(
    wavefront_aligner_t* const wf_aligner,
    wavefront_aligner_attr_t* const attributes) {
  // Parameters
  wavefront_heuristic_t* const wf_heuristic = &attributes->heuristic;
  // Select and configure heuristics
  if (wf_heuristic->strategy == wf_heuristic_none) {
    wavefront_heuristic_set_none(&wf_aligner->heuristic);
  } else {
    // Reset
    wf_aligner->heuristic.strategy = 0;
    // WF-Adaptive
    if (wf_heuristic->strategy & wf_heuristic_wfadaptive) {
      wavefront_heuristic_set_wfadaptive(
          &wf_aligner->heuristic,wf_heuristic->min_wavefront_length,
          wf_heuristic->max_distance_threshold,wf_heuristic->steps_between_cutoffs);
    } else if (wf_heuristic->strategy & wf_heuristic_wfmash) {
      wavefront_heuristic_set_wfmash(
          &wf_aligner->heuristic,wf_heuristic->min_wavefront_length,
          wf_heuristic->max_distance_threshold,wf_heuristic->steps_between_cutoffs);
    }
    // Drops
    if (wf_heuristic->strategy & wf_heuristic_xdrop) {
      wavefront_heuristic_set_xdrop(&wf_aligner->heuristic,
          wf_heuristic->xdrop,wf_heuristic->steps_between_cutoffs);
    } else if (wf_heuristic->strategy & wf_heuristic_zdrop) {
      wavefront_heuristic_set_zdrop(&wf_aligner->heuristic,
          wf_heuristic->zdrop,wf_heuristic->steps_between_cutoffs);
    }
    // Banded
    if (wf_heuristic->strategy & wf_heuristic_banded_static) {
      wavefront_heuristic_set_banded_static(&wf_aligner->heuristic,
          wf_heuristic->min_k,wf_heuristic->max_k);
    } else if (wf_heuristic->strategy & wf_heuristic_banded_adaptive) {
      wavefront_heuristic_set_banded_adaptive(&wf_aligner->heuristic,
          wf_heuristic->min_k,wf_heuristic->max_k,wf_heuristic->steps_between_cutoffs);
    }
  }
}
void wavefront_aligner_init_alignment(
    wavefront_aligner_t* const wf_aligner,
    wavefront_aligner_attr_t* const attributes,
    const bool memory_modular,
    const bool bt_piggyback,
    const bool bi_alignment) {
  // Mode
  wf_aligner->align_mode = (bi_alignment) ? wf_align_biwfa : wf_align_regular;
  wf_aligner->align_mode_tag = NULL;
  // Score & form
  wf_aligner->alignment_scope = attributes->alignment_scope;
  wf_aligner->alignment_form = attributes->alignment_form;
  // Penalties
  wavefront_aligner_init_penalties(wf_aligner,attributes);
  // Memory mode
  wf_aligner->memory_mode = attributes->memory_mode;
  wavefront_aligner_init_heuristic(wf_aligner,attributes);
  // Custom matching functions
  wf_aligner->match_funct = attributes->match_funct;
  wf_aligner->match_funct_arguments = attributes->match_funct_arguments;
}
wavefront_aligner_t* wavefront_aligner_new(
    wavefront_aligner_attr_t* attributes) {
  // Parameters
  if (attributes == NULL) attributes = &wavefront_aligner_attr_default;
  const bool score_only = (attributes->alignment_scope == compute_score);
  const bool memory_succint =
      attributes->memory_mode == wavefront_memory_med ||
      attributes->memory_mode == wavefront_memory_low;
  const bool memory_modular = score_only || memory_succint;
  const bool bt_piggyback = !score_only && memory_succint;
  const bool bi_alignment = (attributes->memory_mode == wavefront_memory_ultralow);
  // Handler
  wavefront_aligner_t* const wf_aligner = wavefront_aligner_init_mm(
      attributes->mm_allocator,memory_modular,bt_piggyback,bi_alignment);
  // Plot
  if (attributes->plot.enabled) {
    wf_aligner->plot = wavefront_plot_new(attributes->distance_metric,
        PATTERN_LENGTH_INIT,TEXT_LENGTH_INIT,&attributes->plot);
  } else {
    wf_aligner->plot = NULL;
  }
  // Alignment
  wavefront_aligner_init_alignment(wf_aligner,attributes,memory_modular,bt_piggyback,bi_alignment);
  if (bi_alignment) {
    wf_aligner->bialigner = wavefront_bialigner_new(attributes,wf_aligner->plot);
  } else {
    wf_aligner->bialigner = NULL;
    // Wavefront components
    wavefront_components_allocate(
        &wf_aligner->wf_components,PATTERN_LENGTH_INIT,TEXT_LENGTH_INIT,
        &wf_aligner->penalties,memory_modular,bt_piggyback,
        wf_aligner->mm_allocator);
  }
  // Sequences
  wf_aligner->sequences = NULL;
  // CIGAR
  const int cigar_length = (score_only) ? 10 : 2*(PATTERN_LENGTH_INIT+TEXT_LENGTH_INIT);
  wf_aligner->cigar = cigar_new(cigar_length,wf_aligner->mm_allocator);
  // System
  wf_aligner->system = attributes->system;
  // Return
  return wf_aligner;
}
void wavefront_aligner_reap(
    wavefront_aligner_t* const wf_aligner) {
  // Padded sequences
  if (wf_aligner->sequences != NULL) {
    strings_padded_delete(wf_aligner->sequences);
    wf_aligner->sequences = NULL;
  }
  // Select alignment mode
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_reap(wf_aligner->bialigner);
  } else {
    // Wavefront components
    wavefront_components_reap(&wf_aligner->wf_components);
    // Slab
    wavefront_slab_reap(wf_aligner->wavefront_slab);
  }
}
void wavefront_aligner_delete(
    wavefront_aligner_t* const wf_aligner) {
  // Parameters
  mm_allocator_t* const mm_allocator = wf_aligner->mm_allocator;
  const bool mm_allocator_own = wf_aligner->mm_allocator_own;
  // Padded sequences
  if (wf_aligner->sequences != NULL) {
    strings_padded_delete(wf_aligner->sequences);
  }
  // Select alignment mode
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_delete(wf_aligner->bialigner);
  } else {
    // Wavefront components
    wavefront_components_free(&wf_aligner->wf_components);
    // Slab
    wavefront_slab_delete(wf_aligner->wavefront_slab);
  }
  // CIGAR
  cigar_free(wf_aligner->cigar);
  // Plot
  if (wf_aligner->plot != NULL && wf_aligner->align_mode <= 1) {
    wavefront_plot_delete(wf_aligner->plot);
  }
  // MM
  mm_allocator_free(mm_allocator,wf_aligner);
  if (mm_allocator_own) {
    mm_allocator_delete(wf_aligner->mm_allocator);
  }
}
/*
 * Span configuration
 */
void wavefront_aligner_set_alignment_end_to_end(
    wavefront_aligner_t* const wf_aligner) {
  wf_aligner->alignment_form.span = alignment_end2end;
}
void wavefront_aligner_set_alignment_free_ends(
    wavefront_aligner_t* const wf_aligner,
    const int pattern_begin_free,
    const int pattern_end_free,
    const int text_begin_free,
    const int text_end_free) {
  wf_aligner->alignment_form.span = alignment_endsfree;
  wf_aligner->alignment_form.pattern_begin_free = pattern_begin_free;
  wf_aligner->alignment_form.pattern_end_free = pattern_end_free;
  wf_aligner->alignment_form.text_begin_free = text_begin_free;
  wf_aligner->alignment_form.text_end_free = text_end_free;
}
/*
 * Heuristic configuration
 */
void wavefront_aligner_set_heuristic_none(
    wavefront_aligner_t* const wf_aligner) {
  wavefront_heuristic_set_none(&wf_aligner->heuristic);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
void wavefront_aligner_set_heuristic_banded_static(
    wavefront_aligner_t* const wf_aligner,
    const int band_min_k,
    const int band_max_k) {
  wavefront_heuristic_set_banded_static(&wf_aligner->heuristic,band_min_k,band_max_k);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
void wavefront_aligner_set_heuristic_banded_adaptive(
    wavefront_aligner_t* const wf_aligner,
    const int band_min_k,
    const int band_max_k,
    const int score_steps) {
  wavefront_heuristic_set_banded_adaptive(
      &wf_aligner->heuristic,band_min_k,band_max_k,score_steps);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
void wavefront_aligner_set_heuristic_wfadaptive(
    wavefront_aligner_t* const wf_aligner,
    const int min_wavefront_length,
    const int max_distance_threshold,
    const int score_steps) {
  wavefront_heuristic_set_wfadaptive(
      &wf_aligner->heuristic,
      min_wavefront_length,max_distance_threshold,score_steps);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
void wavefront_aligner_set_heuristic_wfmash(
    wavefront_aligner_t* const wf_aligner,
    const int min_wavefront_length,
    const int max_distance_threshold,
    const int score_steps) {
  wavefront_heuristic_set_wfmash(
      &wf_aligner->heuristic,
      min_wavefront_length,max_distance_threshold,score_steps);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
void wavefront_aligner_set_heuristic_xdrop(
    wavefront_aligner_t* const wf_aligner,
    const int xdrop,
    const int score_steps) {
  wavefront_heuristic_set_xdrop(&wf_aligner->heuristic,xdrop,score_steps);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
void wavefront_aligner_set_heuristic_zdrop(
    wavefront_aligner_t* const wf_aligner,
    const int ydrop,
    const int score_steps) {
  wavefront_heuristic_set_zdrop(&wf_aligner->heuristic,ydrop,score_steps);
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_heuristic(wf_aligner->bialigner,&wf_aligner->heuristic);
  }
}
/*
 * Match-funct configuration
 */
void wavefront_aligner_set_match_funct(
    wavefront_aligner_t* const wf_aligner,
    int (*match_funct)(int,int,void*),
    void* const match_funct_arguments) {
  wf_aligner->match_funct = match_funct;
  wf_aligner->match_funct_arguments = match_funct_arguments;
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_match_funct(
        wf_aligner->bialigner,match_funct,match_funct_arguments);
  }
}
/*
 * System configuration
 */
void wavefront_aligner_set_max_alignment_score(
    wavefront_aligner_t* const wf_aligner,
    const int max_alignment_score) {
  wf_aligner->system.max_alignment_score = max_alignment_score;
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_max_alignment_score(
        wf_aligner->bialigner,max_alignment_score);
  }
}
void wavefront_aligner_set_max_memory(
    wavefront_aligner_t* const wf_aligner,
    const uint64_t max_memory_resident,
    const uint64_t max_memory_abort) {
  wf_aligner->system.max_memory_resident = max_memory_resident;
  wf_aligner->system.max_memory_abort = max_memory_abort;
  if (wf_aligner->bialigner != NULL) {
    wavefront_bialigner_set_max_memory(
        wf_aligner->bialigner,max_memory_resident,max_memory_abort);
  }
}
void wavefront_aligner_set_max_num_threads(
        wavefront_aligner_t* const wf_aligner,
        const int max_num_threads) {
    wf_aligner->system.max_num_threads = max_num_threads;
    if (wf_aligner->bialigner != NULL) {
        wavefront_bialigner_set_max_num_threads(
          wf_aligner->bialigner,max_num_threads);
    }
}
void wavefront_aligner_set_min_offsets_per_thread(
        wavefront_aligner_t* const wf_aligner,
        const int min_offsets_per_thread) {
    wf_aligner->system.min_offsets_per_thread = min_offsets_per_thread;
    if (wf_aligner->bialigner != NULL) {
        wavefront_bialigner_set_min_offsets_per_thread(
                wf_aligner->bialigner,min_offsets_per_thread);
    }
}
/*
 * Utils
 */
uint64_t wavefront_aligner_get_size(
    wavefront_aligner_t* const wf_aligner) {
  // Parameters
  wavefront_components_t* const wf_components = &wf_aligner->wf_components;
  // Bialigner
  uint64_t sub_aligners = 0;
  if (wf_aligner->bialigner != NULL) {
    return wavefront_bialigner_get_size(wf_aligner->bialigner);
  } else {
    // Compute aligner size
    const uint64_t bt_buffer_size = (wf_components->bt_buffer) ?
        wf_backtrace_buffer_get_size_allocated(wf_components->bt_buffer) : 0;
    const uint64_t slab_size = wavefront_slab_get_size(wf_aligner->wavefront_slab);
    // Return overall size
    return sub_aligners + bt_buffer_size + slab_size;
  }
}
/*
 * Display
 */
void wavefront_aligner_print_type(
    FILE* const stream,
    wavefront_aligner_t* const wf_aligner) {
  if (wf_aligner->align_mode_tag == NULL) {
    switch (wf_aligner->align_mode) {
      case wf_align_biwfa:
        fprintf(stream,"BiWFA");
        break;
      case wf_align_biwfa_breakpoint_forward:
        fprintf(stream,"BiWFA::Forward");
        break;
      case wf_align_biwfa_breakpoint_reverse:
        fprintf(stream,"BiWFA::Reverse");
        break;
      case wf_align_biwfa_subsidiary:
        fprintf(stream,"BiWFA::SubWFA");
        break;
      default:
        fprintf(stream,"WFA");
        break;
    }
  } else {
    fprintf(stream,"%s",wf_aligner->align_mode_tag);
  }
}
void wavefront_aligner_print_scope(
    FILE* const stream,
    wavefront_aligner_t* const wf_aligner) {
  const char* const scope_label =
      (wf_aligner->alignment_scope == compute_score) ? "score" : "alignment";
  if (wf_aligner->alignment_form.span == alignment_end2end) {
    fprintf(stream,"(%s,end2end)",scope_label);
  } else {
    fprintf(stream,"(%s,endsfree,%d,%d,%d,%d)",
        scope_label,
        wf_aligner->alignment_form.pattern_begin_free,
        wf_aligner->alignment_form.pattern_end_free,
        wf_aligner->alignment_form.text_begin_free,
        wf_aligner->alignment_form.text_end_free);
  }
}
void wavefront_aligner_print_mode(
    FILE* const stream,
    wavefront_aligner_t* const wf_aligner) {
  fprintf(stream,"(%s,",(wf_aligner->alignment_scope==compute_score)?"Score":"Alg");
  switch (wf_aligner->memory_mode) {
    case wavefront_memory_high: fprintf(stream,"MHigh)"); break;
    case wavefront_memory_med: fprintf(stream,"MMed)"); break;
    case wavefront_memory_low: fprintf(stream,"MLow)"); break;
    case wavefront_memory_ultralow: fprintf(stream,"BiWFA)"); break;
  }
}