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/*
* The MIT License
*
* Wavefront Alignment Algorithms
* Copyright (c) 2017 by Santiago Marco-Sola <santiagomsola@gmail.com>
*
* This file is part of Wavefront Alignment Algorithms.
*
* Permission is hereby granted, free of charge, to any person obtaining a copy
* of this software and associated documentation files (the "Software"), to deal
* in the Software without restriction, including without limitation the rights
* to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
* copies of the Software, and to permit persons to whom the Software is
* furnished to do so, subject to the following conditions:
*
* The above copyright notice and this permission notice shall be included in all
* copies or substantial portions of the Software.
*
* THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
* IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
* FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
* AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
* LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
* OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
* SOFTWARE.
*
* PROJECT: Wavefront Alignment Algorithms
* AUTHOR(S): Santiago Marco-Sola <santiagomsola@gmail.com>
* DESCRIPTION: WaveFront aligner components
*/
#include "utils/commons.h"
#include "wavefront_components.h"
#include "utils/bitmap.h"
#include "system/profiler_timer.h"
/*
* Configuration
*/
#define WF_NULL_INIT_LO (-1024)
#define WF_NULL_INIT_HI ( 1024)
#define WF_NULL_INIT_LENGTH WAVEFRONT_LENGTH(WF_NULL_INIT_LO,WF_NULL_INIT_HI)
/*
* Compute dimensions
*/
void wavefront_components_dimensions_edit(
wavefront_components_t* const wf_components,
const int max_pattern_length,
const int max_text_length,
int* const max_score_scope,
int* const num_wavefronts) {
// Compute max-scope
*max_score_scope = 2;
// Dimensions
if (wf_components->memory_modular) {
*num_wavefronts = 2;
} else {
*num_wavefronts = MAX(max_pattern_length,max_text_length) + 1;
}
}
void wavefront_components_dimensions_linear(
wavefront_components_t* const wf_components,
wavefront_penalties_t* const penalties,
const int max_pattern_length,
const int max_text_length,
int* const max_score_scope,
int* const num_wavefronts) {
// Compute max-scope
*max_score_scope = MAX(penalties->mismatch,penalties->gap_opening1) + 1;
// Dimensions
if (wf_components->memory_modular) {
*num_wavefronts = *max_score_scope;
} else {
const int abs_seq_diff = ABS(max_pattern_length-max_text_length);
const int max_score_misms = MIN(max_pattern_length,max_text_length) * penalties->mismatch;
const int max_score_indel = penalties->gap_opening1 * abs_seq_diff;
*num_wavefronts = max_score_misms + max_score_indel + 1;
}
}
void wavefront_components_dimensions_affine(
wavefront_components_t* const wf_components,
wavefront_penalties_t* const penalties,
const int max_pattern_length,
const int max_text_length,
int* const max_score_scope,
int* const num_wavefronts) {
// Compute max-scope
const int max_score_scope_indel = penalties->gap_opening1+penalties->gap_extension1;
*max_score_scope = MAX(max_score_scope_indel,penalties->mismatch) + 1;
// Dimensions
if (wf_components->memory_modular) {
*num_wavefronts = *max_score_scope;
} else {
const int abs_seq_diff = ABS(max_pattern_length-max_text_length);
const int max_score_misms = MIN(max_pattern_length,max_text_length) * penalties->mismatch;
const int max_score_indel = penalties->gap_opening1 + abs_seq_diff * penalties->gap_extension1;
*num_wavefronts = max_score_misms + max_score_indel + 1;
}
}
void wavefront_components_dimensions_affine2p(
wavefront_components_t* const wf_components,
wavefront_penalties_t* const penalties,
const int max_pattern_length,
const int max_text_length,
int* const max_score_scope,
int* const num_wavefronts) {
// Compute max-scope
const int max_score_scope_indel =
MAX(penalties->gap_opening1+penalties->gap_extension1,
penalties->gap_opening2+penalties->gap_extension2);
*max_score_scope = MAX(max_score_scope_indel,penalties->mismatch) + 1;
// Dimensions
if (wf_components->memory_modular) {
*num_wavefronts = *max_score_scope;
} else {
const int abs_seq_diff = ABS(max_pattern_length-max_text_length);
const int max_score_misms = MIN(max_pattern_length,max_text_length) * penalties->mismatch;
const int max_score_indel1 = penalties->gap_opening1 + abs_seq_diff * penalties->gap_extension1;
const int max_score_indel2 = penalties->gap_opening2 + abs_seq_diff * penalties->gap_extension2;
const int max_score_indel = MIN(max_score_indel1,max_score_indel2);
*num_wavefronts = max_score_misms + max_score_indel + 1;
}
}
void wavefront_components_dimensions(
wavefront_components_t* const wf_components,
wavefront_penalties_t* const penalties,
const int max_pattern_length,
const int max_text_length,
int* const max_score_scope,
int* const num_wavefronts) {
// Switch attending to distance-metric
switch (penalties->distance_metric) {
case indel:
case edit:
wavefront_components_dimensions_edit(
wf_components,
max_pattern_length,max_text_length,
max_score_scope,num_wavefronts);
break;
case gap_linear:
wavefront_components_dimensions_linear(
wf_components,penalties,
max_pattern_length,max_text_length,
max_score_scope,num_wavefronts);
break;
case gap_affine:
wavefront_components_dimensions_affine(
wf_components,penalties,
max_pattern_length,max_text_length,
max_score_scope,num_wavefronts);
break;
case gap_affine_2p:
wavefront_components_dimensions_affine2p(
wf_components,penalties,
max_pattern_length,max_text_length,
max_score_scope,num_wavefronts);
break;
}
// Clear historic
wf_components->historic_max_hi = 0;
wf_components->historic_min_lo = 0;
}
/*
* Setup
*/
void wavefront_components_allocate_wf(
wavefront_components_t* const wf_components,
const int max_pattern_length,
const int max_text_length,
const distance_metric_t distance_metric) {
// Parameters
const int num_wavefronts = wf_components->num_wavefronts;
const bool init_wf = wf_components->memory_modular;
mm_allocator_t* const mm_allocator = wf_components->mm_allocator;
// Allocate wavefronts
wf_components->mwavefronts = mm_allocator_calloc(mm_allocator,num_wavefronts,wavefront_t*,init_wf);
if (distance_metric <= gap_linear) {
wf_components->i1wavefronts = NULL;
wf_components->d1wavefronts = NULL;
wf_components->i2wavefronts = NULL;
wf_components->d2wavefronts = NULL;
} else {
wf_components->i1wavefronts = mm_allocator_calloc(mm_allocator,num_wavefronts,wavefront_t*,init_wf);
wf_components->d1wavefronts = mm_allocator_calloc(mm_allocator,num_wavefronts,wavefront_t*,init_wf);
if (distance_metric == gap_affine) {
wf_components->i2wavefronts = NULL;
wf_components->d2wavefronts = NULL;
} else {
wf_components->i2wavefronts = mm_allocator_calloc(mm_allocator,num_wavefronts,wavefront_t*,init_wf);
wf_components->d2wavefronts = mm_allocator_calloc(mm_allocator,num_wavefronts,wavefront_t*,init_wf);
}
}
}
void wavefront_components_allocate(
wavefront_components_t* const wf_components,
const int max_pattern_length,
const int max_text_length,
wavefront_penalties_t* const penalties,
const bool memory_modular,
const bool bt_piggyback,
mm_allocator_t* const mm_allocator) {
// Configuration
wf_components->memory_modular = memory_modular;
wf_components->bt_piggyback = bt_piggyback;
wf_components->mm_allocator = mm_allocator; // MM
// Allocate wavefronts
wavefront_components_dimensions(
wf_components,penalties,
max_pattern_length,max_text_length,
&wf_components->max_score_scope,
&wf_components->num_wavefronts);
wavefront_components_allocate_wf(wf_components,
max_pattern_length,max_text_length,penalties->distance_metric);
// Allocate victim wavefront (outside slab)
wavefront_t* const wavefront_victim = mm_allocator_alloc(mm_allocator,wavefront_t);
wavefront_allocate(wavefront_victim,WF_NULL_INIT_LENGTH,bt_piggyback,mm_allocator);
wavefront_init_victim(wavefront_victim,WF_NULL_INIT_LO,WF_NULL_INIT_HI);
wf_components->wavefront_victim = wavefront_victim;
// Allocate null wavefront (outside slab)
wavefront_t* const wavefront_null = mm_allocator_alloc(mm_allocator,wavefront_t);
wavefront_allocate(wavefront_null,WF_NULL_INIT_LENGTH,bt_piggyback,mm_allocator);
wavefront_init_null(wavefront_null,WF_NULL_INIT_LO,WF_NULL_INIT_HI);
wf_components->wavefront_null = wavefront_null;
// BT-Buffer
wf_components->bt_buffer = (bt_piggyback) ? wf_backtrace_buffer_new(mm_allocator) : NULL;
}
void wavefront_components_reap(
wavefront_components_t* const wf_components) {
// BT-Buffer
if (wf_components->bt_buffer) wf_backtrace_buffer_reap(wf_components->bt_buffer);
}
void wavefront_components_clear(
wavefront_components_t* const wf_components) {
// Wavefronts components
if (wf_components->memory_modular) {
const int num_wavefronts = wf_components->num_wavefronts;
const int wf_size = num_wavefronts*sizeof(wavefront_t*);
memset(wf_components->mwavefronts,0,wf_size);
if (wf_components->i1wavefronts) memset(wf_components->i1wavefronts,0,wf_size);
if (wf_components->d1wavefronts) memset(wf_components->d1wavefronts,0,wf_size);
if (wf_components->i2wavefronts) memset(wf_components->i2wavefronts,0,wf_size);
if (wf_components->d2wavefronts) memset(wf_components->d2wavefronts,0,wf_size);
}
wf_components->historic_max_hi = 0;
wf_components->historic_min_lo = 0;
// BT-Buffer
if (wf_components->bt_buffer) wf_backtrace_buffer_clear(wf_components->bt_buffer);
}
void wavefront_components_free_wf(
wavefront_components_t* const wf_components) {
// Parameters
mm_allocator_t* const mm_allocator = wf_components->mm_allocator;
// Wavefronts components
mm_allocator_free(mm_allocator,wf_components->mwavefronts);
if (wf_components->i1wavefronts) mm_allocator_free(mm_allocator,wf_components->i1wavefronts);
if (wf_components->d1wavefronts) mm_allocator_free(mm_allocator,wf_components->d1wavefronts);
if (wf_components->i2wavefronts) mm_allocator_free(mm_allocator,wf_components->i2wavefronts);
if (wf_components->d2wavefronts) mm_allocator_free(mm_allocator,wf_components->d2wavefronts);
}
void wavefront_components_free(
wavefront_components_t* const wf_components) {
// Parameters
mm_allocator_t* const mm_allocator = wf_components->mm_allocator;
// Wavefronts components
wavefront_components_free_wf(wf_components);
// Null wavefront
wavefront_free(wf_components->wavefront_null,mm_allocator);
mm_allocator_free(mm_allocator,wf_components->wavefront_null);
// Victim wavefront
wavefront_free(wf_components->wavefront_victim,mm_allocator);
mm_allocator_free(mm_allocator,wf_components->wavefront_victim);
// BT-Buffer
if (wf_components->bt_buffer) wf_backtrace_buffer_delete(wf_components->bt_buffer);
}
/*
* Resize
*/
void wavefront_components_resize(
wavefront_components_t* const wf_components,
const int max_pattern_length,
const int max_text_length,
wavefront_penalties_t* const penalties) {
// Compute dimensions
int num_wavefronts = 0;
wavefront_components_dimensions(
wf_components,penalties,
max_pattern_length,max_text_length,
&wf_components->max_score_scope,&num_wavefronts);
// Resize wavefronts components (if needed)
if (num_wavefronts > wf_components->num_wavefronts) {
wf_components->num_wavefronts = num_wavefronts;
wavefront_components_free_wf(wf_components);
wavefront_components_allocate_wf(wf_components,
max_pattern_length,max_text_length,penalties->distance_metric);
// BT-Buffer
if (wf_components->bt_buffer) wf_backtrace_buffer_clear(wf_components->bt_buffer);
} else {
wavefront_components_clear(wf_components);
}
}
void wavefront_components_resize_null__victim(
wavefront_components_t* const wf_components,
const int lo,
const int hi) {
// Resize null/victim wavefronts (if needed)
if (lo-1 < wf_components->wavefront_null->wf_elements_init_min ||
hi+1 > wf_components->wavefront_null->wf_elements_init_max) {
// Parameters
mm_allocator_t* const mm_allocator = wf_components->mm_allocator;
// Expand and leave some leeway
const int wf_inc = (WAVEFRONT_LENGTH(lo,hi)*3)/2;
const int proposed_lo = lo - wf_inc/2;
const int proposed_hi = hi + wf_inc/2;
const int proposed_wavefront_length = WAVEFRONT_LENGTH(proposed_lo,proposed_hi);
// Reallocate victim wavefront
wavefront_resize(wf_components->wavefront_victim,proposed_wavefront_length,mm_allocator);
wavefront_init_victim(wf_components->wavefront_victim,proposed_lo,proposed_hi);
// Allocate null wavefront
wavefront_resize(wf_components->wavefront_null,proposed_wavefront_length,mm_allocator);
wavefront_init_null(wf_components->wavefront_null,proposed_lo,proposed_hi);
}
}
/*
* Mark wavefronts
*/
void wavefront_components_mark_backtrace(
wf_backtrace_buffer_t* const bt_buffer,
bitmap_t* const bitmap,
wavefront_t* const wavefront) {
// Parameters
wf_offset_t* const offsets = wavefront->offsets;
bt_block_idx_t* const bt_prev = wavefront->bt_prev;
const int lo = wavefront->lo;
const int hi = wavefront->hi;
// Mark all wavefront backtraces (batch mode)
wf_backtrace_buffer_mark_backtrace_batch(
bt_buffer,offsets+lo,bt_prev+lo,hi-lo+1,bitmap);
// int i;
// for (i=lo;i<=hi;++i) {
// if (offsets[i]>=0) wf_backtrace_buffer_mark_backtrace(bt_buffer,bt_prev[i],bitmap);
// }
}
void wavefront_components_mark_wavefronts(
wavefront_components_t* const wf_components,
bitmap_t* const bitmap,
const int score) {
// Parameters
wf_backtrace_buffer_t* const bt_buffer = wf_components->bt_buffer;
const int max_score_scope = wf_components->max_score_scope;
// Mark Active Working Set (AWS)
int i;
for (i=0;i<max_score_scope;++i) {
// Compute score
const int score_mod = (score-i) % wf_components->max_score_scope;
// Mark M-wavefront
wavefront_t* const mwavefront = wf_components->mwavefronts[score_mod];
if (mwavefront!=NULL) wavefront_components_mark_backtrace(bt_buffer,bitmap,mwavefront);
// Mark (I1/D1)-wavefronts
if (wf_components->i1wavefronts != NULL) {
wavefront_t* const i1wavefront = wf_components->i1wavefronts[score_mod];
if (i1wavefront!=NULL) wavefront_components_mark_backtrace(bt_buffer,bitmap,i1wavefront);
wavefront_t* const d1wavefront = wf_components->d1wavefronts[score_mod];
if (d1wavefront!=NULL) wavefront_components_mark_backtrace(bt_buffer,bitmap,d1wavefront);
// Mark (I2/D2)-wavefronts
if (wf_components->i2wavefronts != NULL) {
wavefront_t* const i2wavefront = wf_components->i2wavefronts[score_mod];
if (i2wavefront!=NULL) wavefront_components_mark_backtrace(bt_buffer,bitmap,i2wavefront);
wavefront_t* const d2wavefront = wf_components->d2wavefronts[score_mod];
if (d2wavefront!=NULL) wavefront_components_mark_backtrace(bt_buffer,bitmap,d2wavefront);
}
}
}
// Update counters in marked bitmap
bitmap_update_counters(bitmap);
}
/*
* Translate block-idxs
*/
void wavefront_components_translate_idx(
wavefront_components_t* const wf_components,
bitmap_t* const bitmap,
wavefront_t* const wavefront) {
// Parameters
wf_offset_t* const offsets = wavefront->offsets;
bt_block_idx_t* const bt_prev = wavefront->bt_prev;
const int lo = wavefront->lo;
const int hi = wavefront->hi;
const bt_block_idx_t num_compacted_blocks = wf_components->bt_buffer->num_compacted_blocks;
// Translate all wavefront block-idxs
int k;
for (k=lo;k<=hi;++k) {
if (offsets[k]>=0) { // NOTE bt_prev[k] >= num_compacted_blocks
bt_prev[k] = (bt_prev[k]==BT_BLOCK_IDX_NULL) ?
BT_BLOCK_IDX_NULL :
num_compacted_blocks + bitmap_erank(bitmap,bt_prev[k]);
}
}
}
void wavefront_components_translate_wavefronts(
wavefront_components_t* const wf_components,
bitmap_t* const bitmap,
const int score) {
// Mark Active Working Set (AWS)
const int max_score_scope = wf_components->max_score_scope;
int i;
for (i=0;i<max_score_scope;++i) {
// Compute score
const int score_mod = (score-i) % wf_components->max_score_scope;
// Mark M-wavefront
wavefront_t* const mwavefront = wf_components->mwavefronts[score_mod];
if (mwavefront!=NULL) wavefront_components_translate_idx(wf_components,bitmap,mwavefront);
// Mark (I1/D1)-wavefronts
if (wf_components->i1wavefronts != NULL) {
wavefront_t* const i1wavefront = wf_components->i1wavefronts[score_mod];
if (i1wavefront!=NULL) wavefront_components_translate_idx(wf_components,bitmap,i1wavefront);
wavefront_t* const d1wavefront = wf_components->d1wavefronts[score_mod];
if (d1wavefront!=NULL) wavefront_components_translate_idx(wf_components,bitmap,d1wavefront);
// Mark (I2/D2)-wavefronts
if (wf_components->i2wavefronts != NULL) {
wavefront_t* const i2wavefront = wf_components->i2wavefronts[score_mod];
if (i2wavefront!=NULL) wavefront_components_translate_idx(wf_components,bitmap,i2wavefront);
wavefront_t* const d2wavefront = wf_components->d2wavefronts[score_mod];
if (d2wavefront!=NULL) wavefront_components_translate_idx(wf_components,bitmap,d2wavefront);
}
}
}
}
/*
* Compact
*/
void wavefront_components_compact_bt_buffer(
wavefront_components_t* const wf_components,
const int score,
const int verbose) {
// PROFILE
profiler_timer_t timer;
if (verbose >= 3) { timer_reset(&timer); timer_start(&timer); }
// Parameters
wf_backtrace_buffer_t* const bt_buffer = wf_components->bt_buffer;
const uint64_t bt_buffer_used = wf_backtrace_buffer_get_used(bt_buffer);
// Allocate bitmap
bitmap_t* const bitmap = bitmap_new(bt_buffer_used,wf_components->mm_allocator);
// Mark Active Working Set (AWS)
wavefront_components_mark_wavefronts(wf_components,bitmap,score);
// Compact marked blocks (also translates idxs to compacted positions)
const bt_block_idx_t total_compacted_blocks =
wf_backtrace_buffer_compact_marked(bt_buffer,bitmap,verbose);
// Translate Active Working Set (AWS)
wavefront_components_translate_wavefronts(wf_components,bitmap,score);
// Set new compacted blocks
wf_backtrace_buffer_set_num_compacted_blocks(bt_buffer,total_compacted_blocks);
// Free
bitmap_delete(bitmap);
// PROFILE
if (verbose >= 3) {
timer_stop(&timer);
fprintf(stderr,"[");
timer_print_total(stderr,&timer);
fprintf(stderr,"]\n");
}
}
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