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/*
* The MIT License
*
* Wavefront Alignment Algorithms
* Copyright (c) 2017 by Santiago Marco-Sola <santiagomsola@gmail.com>
*
* This file is part of Wavefront Alignment Algorithms.
*
* Permission is hereby granted, free of charge, to any person obtaining a copy
* of this software and associated documentation files (the "Software"), to deal
* in the Software without restriction, including without limitation the rights
* to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
* copies of the Software, and to permit persons to whom the Software is
* furnished to do so, subject to the following conditions:
*
* The above copyright notice and this permission notice shall be included in all
* copies or substantial portions of the Software.
*
* THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
* IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
* FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
* AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
* LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
* OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
* SOFTWARE.
*
* PROJECT: Wavefront Alignment Algorithms
* AUTHOR(S): Santiago Marco-Sola <santiagomsola@gmail.com>
* DESCRIPTION: WaveFront alignment module for computing wavefronts (edit/indel)
*/
#include "utils/commons.h"
#include "system/mm_allocator.h"
#include "utils/string_padded.h"
#include "wavefront_compute.h"
#include "wavefront_backtrace_offload.h"
#ifdef WFA_PARALLEL
#include <omp.h>
#endif
/*
* Compute Kernels
*/
void wavefront_compute_indel_idm(
wavefront_aligner_t* const wf_aligner,
wavefront_t* const wf_prev,
wavefront_t* const wf_curr,
const int lo,
const int hi) {
// Parameters
const int pattern_length = wf_aligner->pattern_length;
const int text_length = wf_aligner->text_length;
const wf_offset_t* const prev_offsets = wf_prev->offsets;
wf_offset_t* const curr_offsets = wf_curr->offsets;
// Compute-Next kernel loop
int k;
PRAGMA_LOOP_VECTORIZE
for (k=lo;k<=hi;++k) {
// Compute maximum offset
const wf_offset_t ins = prev_offsets[k-1] + 1;
const wf_offset_t del = prev_offsets[k+1];
wf_offset_t max = MAX(del,ins);
// Adjust offset out of boundaries !(h>tlen,v>plen) (here to allow vectorization)
const wf_unsigned_offset_t h = WAVEFRONT_H(k,max); // Make unsigned to avoid checking negative
const wf_unsigned_offset_t v = WAVEFRONT_V(k,max); // Make unsigned to avoid checking negative
if (h > text_length) max = WAVEFRONT_OFFSET_NULL;
if (v > pattern_length) max = WAVEFRONT_OFFSET_NULL;
curr_offsets[k] = max;
}
}
void wavefront_compute_edit_idm(
wavefront_aligner_t* const wf_aligner,
wavefront_t* const wf_prev,
wavefront_t* const wf_curr,
const int lo,
const int hi) {
// Parameters
const int pattern_length = wf_aligner->pattern_length;
const int text_length = wf_aligner->text_length;
const wf_offset_t* const prev_offsets = wf_prev->offsets;
wf_offset_t* const curr_offsets = wf_curr->offsets;
// Compute-Next kernel loop
int k;
PRAGMA_LOOP_VECTORIZE
for (k=lo;k<=hi;++k) {
// Compute maximum offset
const wf_offset_t ins = prev_offsets[k-1]; // Lower
const wf_offset_t del = prev_offsets[k+1]; // Upper
const wf_offset_t misms = prev_offsets[k]; // Mid
wf_offset_t max = MAX(del,MAX(ins,misms)+1);
// Adjust offset out of boundaries !(h>tlen,v>plen) (here to allow vectorization)
const wf_unsigned_offset_t h = WAVEFRONT_H(k,max); // Make unsigned to avoid checking negative
const wf_unsigned_offset_t v = WAVEFRONT_V(k,max); // Make unsigned to avoid checking negative
if (h > text_length) max = WAVEFRONT_OFFSET_NULL;
if (v > pattern_length) max = WAVEFRONT_OFFSET_NULL;
curr_offsets[k] = max;
}
}
/*
* Compute Kernel (Piggyback)
*/
void wavefront_compute_indel_idm_piggyback(
wavefront_aligner_t* const wf_aligner,
wavefront_t* const wf_prev,
wavefront_t* const wf_curr,
const int lo,
const int hi,
const int score) {
// Parameters
const int pattern_length = wf_aligner->pattern_length;
const int text_length = wf_aligner->text_length;
// Previous WF
const wf_offset_t* const prev_offsets = wf_prev->offsets;
const pcigar_t* const prev_pcigar = wf_prev->bt_pcigar;
const bt_block_idx_t* const prev_bt_idx = wf_prev->bt_prev;
// Current WF
wf_offset_t* const curr_offsets = wf_curr->offsets;
pcigar_t* const curr_pcigar = wf_curr->bt_pcigar;
bt_block_idx_t* const curr_bt_idx = wf_curr->bt_prev;
// Compute-Next kernel loop
int k;
PRAGMA_LOOP_VECTORIZE // Ifs predicated by the compiler
for (k=lo;k<=hi;++k) {
// Compute maximum offset
const wf_offset_t ins = prev_offsets[k-1] + 1;
const wf_offset_t del = prev_offsets[k+1];
wf_offset_t max = MAX(del,ins);
// Update pcigar & bt-block
if (max == del) {
curr_pcigar[k] = PCIGAR_PUSH_BACK_DEL(prev_pcigar[k+1]);
curr_bt_idx[k] = prev_bt_idx[k+1];
} else { // max == ins
curr_pcigar[k] = PCIGAR_PUSH_BACK_INS(prev_pcigar[k-1]);
curr_bt_idx[k] = prev_bt_idx[k-1];
}
// Adjust offset out of boundaries !(h>tlen,v>plen) (here to allow vectorization)
const wf_unsigned_offset_t h = WAVEFRONT_H(k,max); // Make unsigned to avoid checking negative
const wf_unsigned_offset_t v = WAVEFRONT_V(k,max); // Make unsigned to avoid checking negative
if (h > text_length) max = WAVEFRONT_OFFSET_NULL;
if (v > pattern_length) max = WAVEFRONT_OFFSET_NULL;
curr_offsets[k] = max;
}
}
void wavefront_compute_edit_idm_piggyback(
wavefront_aligner_t* const wf_aligner,
wavefront_t* const wf_prev,
wavefront_t* const wf_curr,
const int lo,
const int hi,
const int score) {
// Parameters
const int pattern_length = wf_aligner->pattern_length;
const int text_length = wf_aligner->text_length;
// Previous WF
const wf_offset_t* const prev_offsets = wf_prev->offsets;
const pcigar_t* const prev_pcigar = wf_prev->bt_pcigar;
const bt_block_idx_t* const prev_bt_idx = wf_prev->bt_prev;
// Current WF
wf_offset_t* const curr_offsets = wf_curr->offsets;
pcigar_t* const curr_pcigar = wf_curr->bt_pcigar;
bt_block_idx_t* const curr_bt_idx = wf_curr->bt_prev;
// Compute-Next kernel loop
int k;
PRAGMA_LOOP_VECTORIZE // Ifs predicated by the compiler
for (k=lo;k<=hi;++k) {
// Compute maximum offset
const wf_offset_t ins = prev_offsets[k-1] + 1; // Lower
const wf_offset_t del = prev_offsets[k+1]; // Upper
const wf_offset_t misms = prev_offsets[k] + 1; // Mid
wf_offset_t max = MAX(del,MAX(ins,misms));
// Update pcigar & bt-block
if (max == ins) {
curr_pcigar[k] = PCIGAR_PUSH_BACK_INS(prev_pcigar[k-1]);
curr_bt_idx[k] = prev_bt_idx[k-1];
}
if (max == del) {
curr_pcigar[k] = PCIGAR_PUSH_BACK_DEL(prev_pcigar[k+1]);
curr_bt_idx[k] = prev_bt_idx[k+1];
}
if (max == misms) {
curr_pcigar[k] = PCIGAR_PUSH_BACK_MISMS(prev_pcigar[k]);
curr_bt_idx[k] = prev_bt_idx[k];
}
// Adjust offset out of boundaries !(h>tlen,v>plen) (here to allow vectorization)
const wf_unsigned_offset_t h = WAVEFRONT_H(k,max); // Make unsigned to avoid checking negative
const wf_unsigned_offset_t v = WAVEFRONT_V(k,max); // Make unsigned to avoid checking negative
if (h > text_length) max = WAVEFRONT_OFFSET_NULL;
if (v > pattern_length) max = WAVEFRONT_OFFSET_NULL;
curr_offsets[k] = max;
}
}
/*
* Exact pruning paths
*/
int wf_compute_edit_best_score(
const int pattern_length,
const int text_length,
const int k,
const wf_offset_t offset) {
// Compute best-alignment case
const int left_v = pattern_length - WAVEFRONT_V(k,offset);
const int left_h = text_length - WAVEFRONT_H(k,offset);
return (left_v >= left_h) ? left_v - left_h : left_h - left_v;
}
int wf_compute_edit_worst_score(
const int pattern_length,
const int text_length,
const int k,
const wf_offset_t offset) {
// Compute worst-alignment case
const int left_v = pattern_length - WAVEFRONT_V(k,offset);
const int left_h = text_length - WAVEFRONT_H(k,offset);
return MAX(left_v,left_h);
}
void wavefront_compute_edit_exact_prune(
wavefront_aligner_t* const wf_aligner,
wavefront_t* const wavefront) {
// Parameters
const int plen = wf_aligner->pattern_length;
const int tlen = wf_aligner->text_length;
wf_offset_t* const offsets = wavefront->offsets;
const int lo = wavefront->lo;
const int hi = wavefront->hi;
// Speculative compute if needed
if (WAVEFRONT_LENGTH(lo,hi) < 1000) return;
const int sample_k = lo + (hi-lo)/2;
const wf_offset_t sample_offset = offsets[sample_k];
if (sample_offset < 0) return; // Unlucky null in the middle
const int smax_sample = wf_compute_edit_worst_score(plen,tlen,sample_k,offsets[sample_k]);
const int smin_lo = wf_compute_edit_best_score(plen,tlen,lo,offsets[lo]);
const int smin_hi = wf_compute_edit_best_score(plen,tlen,hi,offsets[hi]);
if (smin_lo <= smax_sample && smin_hi <= smax_sample) return;
/*
* Suggested by Heng Li as an effective exact-prunning technique
* for sequences of very different length where some diagonals
* can be proven impossible to yield better alignments.
*/
// Compute the best worst-case-alignment
int score_min_worst = INT_MAX;
int k;
for (k=lo;k<=hi;++k) {
const wf_offset_t offset = offsets[k];
if (offset < 0) continue; // Skip nulls
// Compute worst-alignment case
const int score_worst = wf_compute_edit_worst_score(plen,tlen,k,offset);
if (score_worst < score_min_worst) score_min_worst = score_worst;
}
// Compare against the best-case-alignment (Prune from bottom)
int lo_reduced = lo;
for (k=lo;k<=hi;++k) {
// Compute best-alignment case
const wf_offset_t offset = offsets[k];
const int score_best = wf_compute_edit_best_score(plen,tlen,k,offset);
// Compare best and worst
if (score_best <= score_min_worst) break;
++lo_reduced;
}
wavefront->lo = lo_reduced;
// Compare against the best-case-alignment (Prune from top)
int hi_reduced = hi;
for (k=hi;k>lo_reduced;--k) {
// Compute best-alignment case
const wf_offset_t offset = offsets[k];
const int score_best = wf_compute_edit_best_score(plen,tlen,k,offset);
// Compare best and worst
if (score_best <= score_min_worst) break;
--hi_reduced;
}
wavefront->hi = hi_reduced;
}
/*
* Compute next wavefront
*/
void wavefront_compute_edit_dispatcher(
wavefront_aligner_t* const wf_aligner,
const int score,
wavefront_t* const wf_prev,
wavefront_t* const wf_curr,
const int lo,
const int hi) {
if (wf_aligner->wf_components.bt_piggyback) {
if (wf_aligner->penalties.distance_metric == indel) {
wavefront_compute_indel_idm_piggyback(wf_aligner,wf_prev,wf_curr,lo,hi,score);
} else {
wavefront_compute_edit_idm_piggyback(wf_aligner,wf_prev,wf_curr,lo,hi,score);
}
} else {
if (wf_aligner->penalties.distance_metric == indel) {
wavefront_compute_indel_idm(wf_aligner,wf_prev,wf_curr,lo,hi);
} else {
wavefront_compute_edit_idm(wf_aligner,wf_prev,wf_curr,lo,hi);
}
}
}
void wavefront_compute_edit_dispatcher_omp(
wavefront_aligner_t* const wf_aligner,
wavefront_t* const wf_prev,
wavefront_t* const wf_curr,
const int lo,
const int hi,
const int score) {
// Parameters
const int num_threads = wavefront_compute_num_threads(wf_aligner,lo,hi);
// Multithreading dispatcher
if (num_threads == 1) {
// Compute next wavefront
wavefront_compute_edit_dispatcher(
wf_aligner,score,wf_prev,wf_curr,lo,hi);
} else {
#ifdef WFA_PARALLEL
// Compute next wavefront in parallel
#pragma omp parallel num_threads(num_threads)
{
int t_lo, t_hi;
const int thread_id = omp_get_thread_num();
const int thread_num = omp_get_num_threads();
wavefront_compute_thread_limits(thread_id,thread_num,lo,hi,&t_lo,&t_hi);
wavefront_compute_edit_dispatcher(
wf_aligner,score,wf_prev,wf_curr,t_lo,t_hi);
}
#endif
}
}
void wavefront_compute_edit(
wavefront_aligner_t* const wf_aligner,
const int score) {
// Parameters
wavefront_components_t* const wf_components = &wf_aligner->wf_components;
// Compute scores
int score_prev = score - 1;
int score_curr = score;
if (wf_components->memory_modular) { // Modular wavefront
score_prev = score_prev % wf_components->max_score_scope;
score_curr = score_curr % wf_components->max_score_scope;
if (wf_components->mwavefronts[score_curr]) { // Free
wavefront_slab_free(wf_aligner->wavefront_slab,wf_components->mwavefronts[score_curr]);
}
}
// Fetch previous wavefront, compute limits & initialize
wavefront_t* const wf_prev = wf_components->mwavefronts[score_prev];
const int lo = wf_prev->lo - 1;
const int hi = wf_prev->hi + 1;
// wf_components->historic_min_lo = min_lo;
// wf_components->historic_max_hi = max_hi;
wf_prev->offsets[lo-1] = WAVEFRONT_OFFSET_NULL;
wf_prev->offsets[lo] = WAVEFRONT_OFFSET_NULL;
wf_prev->offsets[hi] = WAVEFRONT_OFFSET_NULL;
wf_prev->offsets[hi+1] = WAVEFRONT_OFFSET_NULL;
// Allocate output wavefront
wavefront_t* const wf_curr = wavefront_slab_allocate(wf_aligner->wavefront_slab,lo-2,hi+2);
wf_components->mwavefronts[score_curr] = wf_curr;
wf_components->mwavefronts[score_curr]->lo = lo;
wf_components->mwavefronts[score_curr]->hi = hi;
// Compute Wavefront
wavefront_compute_edit_dispatcher_omp(wf_aligner,wf_prev,wf_curr,lo,hi,score);
// Offload backtrace (if necessary)
if (wf_components->bt_piggyback && score % PCIGAR_MAX_LENGTH == 0) {
wavefront_backtrace_offload_blocks_linear(
wf_aligner,wf_curr->offsets,wf_curr->bt_pcigar,wf_curr->bt_prev,lo,hi);
}
// Trim wavefront ends
wavefront_compute_trim_ends(wf_aligner,wf_curr);
if (wf_curr->null) wf_aligner->align_status.num_null_steps = INT_MAX;
// Exact pruning paths
if (wf_aligner->alignment_form.span == alignment_end2end &&
wf_aligner->penalties.distance_metric == edit) {
wavefront_compute_edit_exact_prune(wf_aligner,wf_curr);
}
}
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